Hayashi Jun-Ichi 林純一

… Alternative Names

Researcher Number	60142113
Other IDs
External Links
Affiliation (Current)	2020: 筑波大学, 生命環境系(名誉教授), 名誉教授
Affiliation (based on the past Project Information) *help	2016 – 2020: 筑波大学, 生命環境系(名誉教授), 名誉教授 2018: 筑波大学, 生存ダイナミクス研究センター, 名誉教授、生存ダイナミクス研究センター長 2015: 筑波大学, 生命環境系, 特命教授 2011 – 2014: 筑波大学, 生命環境系, 教授 2011: 筑波大学, 生命環境科学研究科(系), 教授 … More
Review Section/Research Field	Principal Investigator 老化(加齢) / Biological Sciences / Laboratory animal science / Laboratory animal science / 遺伝 / Laboratory animal science / Neurology / Basic Section 42040:Laboratory animal science-related Except Principal Investigator 体育学 / Pathological medical chemistry / General medical chemistry
Keywords	Principal Investigator 老化 / 病態モデルマウス / マウスmtDNA / ミトコンドリア病 / ミトコンドリアDNA / ミトコンドリア移植 / mtDNA突然変異 / 突然変異 / ミトコンドリア遺伝子疾患 / ミトコンドリアtRNA … More Except Principal Investigator ミトコンドリア / ミトコンドリアDNA / aging / exercise / mitochondorial DNA / ATP合成 / FoF_1 / 酸化的リン酸化 / 老化 / α_3β_3複合体 / mtDNA変異 / 肺癌 / 大腸癌 / 原発巣 / 転移巣 / 神経膠腫 / 髄液播種 / ラマンバンド / ROS / 転移能 / 肺癌・大腸癌 / 癌部と非癌部 / 神経膠芽腫 / mtDNA / 変異 / ヒト腫瘍 / テラトカルシノーマ / 核移植細胞 / 細胞工学方法 / 腫瘍遺伝子 / H^+輸送 / ATP合成酵素 / FoFl / 部位特異的変異 / 細胞エネルギー代謝調節 / トランスジェニックマウス / サイブリド / 呼吸鎖酵素 / パーティクルガン / 細胞融合 / 心筋症 / ミトコンドリア脳筋症 / タンパク質合成 / Alpers病 / パーラィクルガン / ミトコンドリア胸筋症 / 遺伝子病 / 遺伝子導入 / 金属粒子 / 遺伝子銃 / Mitochondria / Transgenic mouse / Cybrid / Respiratory chain / particle gun / Cell fusion / Mitochondrial encephalomyopathy / Cardiomyopathy / 筋萎縮 / 運動 / 筋横断面積 / 運動ニューロン / 筋代謝 / muscle atrophy / muscle cross-sectional area / motoneurons / 欠失 / 急性運動 / 持久的トレーニング / 突然変異 / 加齢 Less

Does age-associated down regulation of human SHMT2 and GCAT genes induce short lifespan or longevity?Principal InvestigatorOngoing
- Principal Investigator
  
  林純一
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  University of Tsukuba
Investigation of age-associated mitochondrial disorders caused by mtDNA or unknown cytoplasmic genetic elements found in mouse strainsPrincipal Investigator
- Principal Investigator
  
  HAYASHI Jun-Ichi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Laboratory animal science
- Research Institution
  University of Tsukuba
Paradigm shift of mammalian mitochondrial genome using intercellular transfer technologyPrincipal Investigator
- Principal Investigator
  
  HAYASHI Jun-Ichi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Laboratory animal science
- Research Institution
  University of Tsukuba
核ーミトコンドリアゲノム間の機能的不和合性を導入したモデル生物の作出Principal Investigator
- Principal Investigator
  
  林純一
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  University of Tsukuba
Comparison of the frequency of mtDNA mutation in primary and metastatic lesions of human malignant tumors
- Principal Investigator
  
  KOSHIKAWA Nobuko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Chiba Cancer Center (Research Institute)
Analysis of entire physiological roles of mammalian mtDNA by generation of mice carrying various pathogenic mutationsPrincipal Investigator
- Principal Investigator
  
  HAYASHI Jun-ichi
- Project Period (FY)
  2007 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Laboratory animal science
- Research Institution
  University of Tsukuba
Studies on pathogenesis and gene therapy using mice with the mutated mtDNA in tRNA genesPrincipal Investigator
- Principal Investigator
  
  HAYASHI Jun-ichi
- Project Period (FY)
  2002 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Tsukuba
Application of disease-model mice with mutant mtDNA for precise investigation of its pathogenesisPrincipal Investigator
- Principal Investigator
  
  HAYASHI Jun-Ichi
- Project Period (FY)
  2002 – 2006
- Research Category
  
  Grant-in-Aid for Creative Scientific Research
- Research Institution
  University of Tsukuba
ミトコンドリアDNA突然変異導入マウスを用いたミトコンドリアゲノムの基礎遺伝学Principal Investigator
- Principal Investigator
  
  林純一
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  遺伝
- Research Institution
  University of Tsukuba
マウス人工的突然変異tRNA遺伝子導入によるmtDNAノックアウトマウスの作製Principal Investigator
- Principal Investigator
  
  林純一
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  University of Tsukuba
マウス人工的突然変異tRNA遺伝子導入によるmtDNAノックアウトマウスの作製Principal Investigator
- Principal Investigator
  
  林純一
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  University of Tsukuba
マウス人工的突然変異tRNA遺伝子導入によるmtDNAノックアウトマウスの作製Principal Investigator
- Principal Investigator
  
  林純一
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  University of Tsukuba
Generation and application of mtDNA knockout mice as models for mitochondrial diseasesPrincipal Investigator
- Principal Investigator
  
  HAYASHI Jun-ichi
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Laboratory animal science
- Research Institution
  University of Tsukuba
Effect of endurance training on accumulation of age-associated mitochondrial DNA deletions in old rats.
- Principal Investigator
  
  KUNO Shinya
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  体育学
- Research Institution
  University of Tsukuba
Generation and application of mtDNA knockout mice models of agingPrincipal Investigator
- Principal Investigator
  
  HAYASHI Jun-ichi
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  老化(加齢)
- Research Institution
  University of Tsukuba
マウス人工的突然変異tRNA遺伝子導入によるmtDNAノックアウトマウスの作製Principal Investigator
- Principal Investigator
  
  林純一
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  University of Tsukuba
The mechanism of atrophy in skeletal muscle with aging
- Principal Investigator
  
  KATSUTA Shigeru
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  体育学
- Research Institution
  University of Tsukuba
Analyzes of genes responsible for aging and the pathogenesis of diabetes by isolation of transgenic mice with pathogenic mtDNA mutationPrincipal Investigator
- Principal Investigator
  
  HAYASHI Jun-ichi
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  University of Tsukuba
mtDNA欠損株を用いたヒトの老化とmtDNA突然変異の因果関係の解析Principal Investigator
- Principal Investigator
  
  林純一
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  老化(加齢)
- Research Institution
  University of Tsukuba
Isolation of mtDNA knock-out mice by introduction of disease-related mtDNA mutationPrincipal Investigator
- Principal Investigator
  
  HAYASHI Jun-ichi
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurology
- Research Institution
  University of Tsukuba
ミトコンドリアDNA欠損細胞を用いたヒト・ミトコンドリア病の体細胞遺伝学的解析Principal Investigator
- Principal Investigator
  
  林純一
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Research Institute for Clinical Oncology, Saitama Cancer Center
Construction of transgenic mice into which mutant mitochondrial DNA is artificially introduced.
- Principal Investigator
  
  OHTA Shigeo
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Instute of Gerontology, Nippon Mrdical School
  Jichi Medical University
ATPエネルギー
- Principal Investigator
  
  香川靖雄
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Jichi Medical University
野生マウス由来のmtDNA導入によるマウス・ミトコンドリアゲノムの遺伝学的研究Principal Investigator
- Principal Investigator
  
  林純一
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Research Institute for Clinical Oncology, Saitama Cancer Center
ATPエネルギー
- Principal Investigator
  
  香川靖雄
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Jichi Medical University
野生マウス由来のmtDNA導入によるマウス・ミトコンドリアゲノムの遺伝学的研究Principal Investigator
- Principal Investigator
  
  林純一
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Research Institute for Clinical Oncology, Saitama Cancer Center
ミトコンドリアAIPaseにおける核・ミトコンドリア遺伝子間の相互作用Principal Investigator
- Principal Investigator
  
  林純一
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Research Institute for Clinical Oncology, Saitama Cancer Center
野生マウス由来のmtDNA導入によるマウス・ミトコンドリアゲノムの遺伝学的研究Principal Investigator
- Principal Investigator
  
  林純一
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Research Institute for Clinical Oncology, Saitama Cancer Center
細胞工学方法によるテラトカルシノーマの分化誘導と腫瘍遺伝子発現の制御
- Principal Investigator
  
  関口豊三
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East

[Book] 細胞工学2010
- Author(s)
  今西泰赳, 石川香, 反町典子, 林純一
- Publisher
  学研メディカル秀潤社
- Data Source
  KAKENHI-PROJECT-19100007
[Book] Mitochondrial function(Edited by W. S. Allison and Anne N. Murphy, Generation of mtDNA-exchanged cybrids for determination of the effects of mtDNA mutations on tumor phenotypes Methods in Enzymology, Part B)2009
- Author(s)
  Kaori Ishikawa, Jun-Ichi Hayashi
- Publisher
  Academic Press
- Data Source
  KAKENHI-PROJECT-19100007
[Book] Methods in Enzymology, Part B, Mitochondrial function (Edited by W. S. Allison and Anne N. Murphy), Generation of mtDNA-exchanged cybrids for determination of the effects of mtDNA mutations on tumor phenotypes2009
- Author(s)
  Kaori Ishikawa, Jun-Ichi Hayashi
- Publisher
  Academic Press
- Data Source
  KAKENHI-PROJECT-19100007
[Book] 卵子学:卵子学のミトコンドリアDNA2009
- Author(s)
  設楽浩志、林純一
- Publisher
  京都大学学術出版会(印刷中)
- Data Source
  KAKENHI-PROJECT-19100007
[Book] ミトコンドリアの遺伝機構とエネルギー代謝制御2008
- Author(s)
  林純一、中田和人
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-19100007
[Book] 二層膜オルガネラの遺伝学2005
- Author(s)
  林純一
- Total Pages
  221
- Publisher
  共立出版
- Data Source
  KAKENHI-PROJECT-14035101
[Book] 二層膜オルガネラの遺伝学2005
- Author(s)
  林純一
- Publisher
  共立出版(印刷中)
- Data Source
  KAKENHI-PROJECT-14GS0305
[Book] 二層膜オルガネラの遺伝学2005
- Author(s)
  林純一
- Publisher
  共立出版(印刷中)
- Data Source
  KAKENHI-PROJECT-14035101
[Book] 二層膜オルガネラの遺伝学2005
- Author(s)
  林純一
- Total Pages
  221
- Publisher
  共立出版
- Data Source
  KAKENHI-PROJECT-14GS0305
[Book] ミトコンドリア・ミステリー2002
- Author(s)
  林純一
- Total Pages
  297
- Publisher
  講談社ブルーバックス
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14035101
[Book] ミトコンドリア・ミステリー2002
- Author(s)
  林純一
- Total Pages
  297
- Publisher
  講談社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14GS0305
[Journal Article] Association of predicted pathogenic mutations in mitochondrial ND genes with distant metastasis in NSCLC and colon cancer.2018
- Author(s)
  Koshikawa Nobuko、Akimoto Miho、Hayashi Jun-Ichi、Nagase Hiroki、Takenaga Keizo
- Journal Title
  
  Sci. Rep.
  
  Volume: 7 Pages: 15535-15535
- DOI
  10.1038/s41598-017-15592-2
- NAID
  120006399187
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10594, KAKENHI-PROJECT-16K21177, KAKENHI-PUBLICLY-16H01579, KAKENHI-PROJECT-16H02463, KAKENHI-PROJECT-17H03602
[Journal Article] Propofol induces a metabolic switch to glycolysis and cell death in a mitochondrial electron transport chain-dependent manner.2018
- Author(s)
  Chisato Sumi, Akihisa Okamoto, Hiromasa Tanaka, Kenichiro Nishi, Munenori Kusunoki, Tomohiro Shoji, Takeo Uba, Yoshiyuki Matsuo, Takehiko Adachi, Jun-Ichi Hayashi, Keizo Takenaga, Kiichi Hirota
- Journal Title
  
  PLoS ONE
  
  Volume: 13
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H02463
[Journal Article] Mice deficient in the Shmt2 gene have mitochondrial respiration defects and are embryonic lethal2018
- Author(s)
  Tani H, Ohnishi S, Shitara H, Mito T, Yamaguchi M, Yonekawa H, Hashizume O, Ishikawa K, Nakada K, Hayashi JI.
- Journal Title
  
  Sci. Rep.
  
  Volume: 8 Pages: 425-425
- DOI
  10.1038/s41598-017-18828-3
- NAID
  120006414319
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K18535, KAKENHI-PROJECT-16K19034, KAKENHI-PROJECT-16H04678, KAKENHI-PROJECT-16K14719, KAKENHI-PROJECT-18K06203, KAKENHI-PROJECT-16H02463, KAKENHI-PROJECT-16H04688, KAKENHI-PROJECT-18J20289
[Journal Article] Mito-mice delta and mitochondrial DNA mutator mice as models of human osteoporosis caused not by aging but by hyperparathyroidism2018
- Author(s)
  Takayuki Mito, Haruna Tani, Michiko Suzuki, Kaori Ishikawa, Kazuto Nakada, Jun-Ichi Hayashi
- Journal Title
  
  Exp. Anim.
  
  Volume: 67 Pages: 509-516
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H02463
[Journal Article] Cytoplasmic transfer of heritable elements other than mtDNA from SAMP1 mice into mouse tumor cells suppresses their ability to form tumors in C57BL6 mice.2017
- Author(s)
  Akinori Shimizu, Haruna Tani, Gaku Takibuchi, Kaori Ishikawa, Ryota Sakurazawa, Takafumi Inoue, Tetsuo Hashimoto, Kazuto Nakada, Keizo Takenaga, and Jun-Ichi Hayashi
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 493 Pages: 252-257
- NAID
  120006360838
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H02463
[Journal Article] A novel mutation in TAZ causes mitochondrial respiratory chain disorder without cardiomyopathy.2017
- Author(s)
  Borna NN, Kishita Y, Ishikawa K, Nakada K, Hayashi JI, Tokuzawa Y, Kohda M, Nyuzuki H, Yamashita-Sugahara Y, Nasu T, Takeda A, Murayama K, Ohtake A, Okazaki Y
- Journal Title
  
  J. Hum. Genet.
  
  Volume: 62 Pages: 539-547
- DOI
  10.1038/jhg.2016.165
- NAID
  40021210340
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04678, KAKENHI-PROJECT-16K14719, KAKENHI-PROJECT-16K09973, KAKENHI-PROJECT-16K18535, KAKENHI-PROJECT-16H02463, KAKENHI-PROJECT-15K09679
[Journal Article] Mutations in mitochondrial DNA regulate mitochondrial diseases and metastasis but do not regulate aging.2016
- Author(s)
  Hayashi JI, Hashizume O, Ishikawa K, Shimizu A.
- Journal Title
  
  Current Opinion in Genetics & Development
  
  Volume: 未定 Pages: 63-67
- DOI
  10.1016/j.gde.2016.03.004
- NAID
  120005954511
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25250011, KAKENHI-PROJECT-16H02463, KAKENHI-PROJECT-16K18535, KAKENHI-PROJECT-16K19034
[Journal Article] 哺乳類ミトコンドリアゲノムの突然変異ががん化と老化に与える影響2016
- Author(s)
  林　純一
- Journal Title
  
  基礎老化研究
  
  Volume: 40 Pages: 9-15
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H02463
[Journal Article] Interleukin-33 enhances programmed oncosis of ST2L-positive low-metastatic cells in the tumour microenvironment of lung cancer.2016
- Author(s)
  Akimoto M, Hayashi JI, Nakae S, Saito H, Takenaga K.
- Journal Title
  
  Cell Death＆Diseases
  
  Volume: 7
- DOI
  10.1038/cddis.2015.418
- NAID
  120005728894
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25430110, KAKENHI-PROJECT-16H02463, KAKENHI-PROJECT-16K21177
[Journal Article] Transmitochondrial mito-mice and mtDNA mutator mice, but not aged mice, share the same spectrum of musculoskeletal disorders2015
- Author(s)
  Mito T, Ishizaki H, Suzuki M, Morishima H, Ota A, Ishikawa K, Nakada K, Maeno A, Shiroishi T, Hayashi J-I
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 456 Pages: 933-7
- DOI
  10.1016/j.bbrc.2014.12.009
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-14J00467, KAKENHI-PLANNED-23117005, KAKENHI-PROJECT-23240058, KAKENHI-PROJECT-25250011
[Journal Article] A novel MitoNEET ligand, TT01001, improves diabetes and ameliorates mitochondrial function in db/db mice.2015
- Author(s)
  Takehiro Takahashi, Masashi Yamamoto, Kazutoshi Amikura, Kozue Kato, Takashi Serizawa,Kanako Serizawa, Daisuke Akazawa, Takumi Aoki, Koji Kawai, Emi Ogasawara, Jun-Ichi Hayashi, Kazuto Nakada, and Mie Kainoh
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 352 Pages: 338-345
- DOI
  10.1124/jpet.114.220673
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23240058, KAKENHI-PROJECT-25250011
[Journal Article] Mouse somatic mutation orthologous to MELAS A3302G mutation in the mitochondrial tRNALeu(UUR) gene confers respiration defects2015
- Author(s)
  Shimizu A, Enoki S, Ishikawa K, Mito T, Obata K, Nagashima R, Yonekawa H, Nakada K, Hayashi J.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 467 Pages: 1097-102
- DOI
  10.1016/j.bbrc.2015.09.072
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23117005, KAKENHI-PROJECT-23240058, KAKENHI-PROJECT-25250011, KAKENHI-PROJECT-14J00467, KAKENHI-PROJECT-25290038
[Journal Article] G7731A mutation in mouse mitochondrial tRNA(Lys) regulates late-onset disorders in transmitochondrial mice.2015
- Author(s)
  Shimizu A, Mito T, Hashizume O, Yonekawa H, Ishikawa K, Nakada K, Hayashi J-I
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 459 Pages: 66-70
- DOI
  10.1016/j.bbrc.2015.02.070
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-14J00467, KAKENHI-PLANNED-23117005, KAKENHI-PROJECT-23240058, KAKENHI-PROJECT-25250011, KAKENHI-PROJECT-25640057, KAKENHI-PROJECT-25290038
[Journal Article] A somatic T15091C mutation in the cytb gene of mouse mitochondrial DNA dominantly induces respiration defects.2015
- Author(s)
  Hayashi C, Takibuchi G, Shimizu A, Mito T, Ishikawa K, Nakada K, Hayashi JI
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 463 Pages: 1021-1027
- DOI
  10.1016/j.bbrc.2015.06.052
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23240058, KAKENHI-PROJECT-25250011, KAKENHI-PROJECT-14J00467
[Journal Article] A Specific Nuclear DNA Background Is Required for High Frequency Lymphoma Development in Transmitochondrial Mice with G13997A mtDNA.2015
- Author(s)
  Osamu Hashizume, Haruka Yamanashi, Makoto M. Taketo, Kazuto Nakada, and Jun-Ichi Hayashi
- Journal Title
  
  PLoS One
  
  Volume: 10
- DOI
  10.1371/journal.pone.0118561
- NAID
  120005604045
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23240058, KAKENHI-PROJECT-25250011
[Journal Article] Epigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-associated mitochondrial respiration defects.2015
- Author(s)
  Hashizume O, Ohnishi S, Mito T, Shimizu A, Ishikawa K, Nakada K, Soda M, Mano H, Togayachi S, Miyoshi H, Okita K, Hayashi J
- Journal Title
  
  Scientific Reports
  
  Volume: 5 Pages: 10343-10343
- DOI
  10.1038/srep10434
- NAID
  120005819481
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461155, KAKENHI-PLANNED-23117005, KAKENHI-PROJECT-23240058, KAKENHI-PROJECT-25250011, KAKENHI-PROJECT-15H06367, KAKENHI-PROJECT-14J00467
[Journal Article] Administration of an Antioxidant Prevents Lymphoma Development in Transmitochondrial Mice Overproducing Reactive Oxygen Species2014
- Author(s)
  Yamanashi H, Hashizume O, Yonekawa H, Nakada K, Hayashi J.
- Journal Title
  
  Experimental Animals
  
  Volume: 63 Issue: 4 Pages: 459-466
- DOI
  10.1538/expanim.14-0038
- NAID
  130005089325
- ISSN
  1341-1357, 1881-7122
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25250011
[Journal Article] Selection of rodent species appropriate for mtDNA transfer to generate transmitochondrial mito-mice expressing mitochondrial respiration defects.2014
- Author(s)
  Enoki S, Shimizu A, Hayashi C, Imanishi H, Hashizume O, Mekada K, Suzuki H, Hashimoto T, Nakada K, Hayashi J
- Journal Title
  
  Exp Anim.
  
  Volume: 63 Pages: 21-30
- NAID
  130003391604
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24117503
[Journal Article] Selection of rodent species appropriate for mtDNA transfer to generate transmitochondrial mito-mice expressing mitochondrial respiration defects.2014
- Author(s)
  Enoki S, Shimizu A, Hayashi C, Imanishi H, Hashizume O, Mekada K, Suzuki H, Hashimoto T, Nakada K, Hayashi J.
- Journal Title
  
  Exp Anim. 2014;63(1):21-30.
  
  Volume: 63 Pages: 21-30
- NAID
  130003391604
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25250011
[Journal Article] Transmitochondrial mice as models for primary prevention of diseases caused by mutation in the tRNALys gene.2014
- Author(s)
  Shimizu A, Mito T, Hayashi C, Ogasawara E, Koba R, Negishi I, Takenaga K, Nakada K, Hayashi J
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 111 Pages: 3104-3109
- DOI
  10.1073/pnas.1318109111
- NAID
  120005425930
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240058, KAKENHI-PUBLICLY-24117503, KAKENHI-PROJECT-25250011, KAKENHI-PROJECT-25430110
[Journal Article] Polymorphic mutations in mouse mitochondrial DNA regulate a tumor phenotype.2013
- Author(s)
  Takibuchi G, Imanishi H, Morimoto M, Ishikawa K, Nakada K, Toyama-Sorimachi N, Kikkawa Y, Takenaga K, Hayashi J
- Journal Title
  
  Mitochondrion.
  
  Volume: 13 Pages: 881-887
- DOI
  10.1016/j.mito.2013.07.117
- NAID
  120005366064
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240058, KAKENHI-PUBLICLY-24117503, KAKENHI-PROJECT-25250011, KAKENHI-PROJECT-25430110
[Journal Article] Specific mtDNA Mutations in Mouse Carcinoma Cells Suppress Their Tumor Formation via Activation of the Host Innate Immune System2013
- Author(s)
  Imanishi H, Takibuchi G, Kobayashi T, Ishikawa K, Nakada K, Mori M, Kikkawa Y, Takenaga K, Toyama-Sorimachi N, Hayashi J
- Journal Title
  
  PLoS ONE
  
  Volume: 8
- DOI
  10.1371/journal.pone.0075981
- NAID
  120005345623
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240058, KAKENHI-PUBLICLY-24117503, KAKENHI-PROJECT-24500487, KAKENHI-PROJECT-25250011, KAKENHI-PROJECT-25430110, KAKENHI-PROJECT-25871165
[Journal Article] Mitochondrial DNA with a large-scale deletion causes two distinct mitochondrial disease phenotypes in mice.2013
- Author(s)
  Katada S, Mito T, Ogasawara E, Hayashi J, Nakada K
- Journal Title
  
  G3 (Bethesda).
  
  Volume: 3 Pages: 1545-1552
- DOI
  10.1534/g3.113.007245
- NAID
  120005342668
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240058, KAKENHI-PUBLICLY-24117503, KAKENHI-PROJECT-25250011
[Journal Article] Specific mitochondrial DNA mutation in mice regulates diabetes and lymphoma development2012
- Author(s)
  Osamu Hashizume, Akinori Shimizu, Mutsumi Yokota, Atsuko Sugiyama, Kazuto Nakada, Hiroyuki Miyoshi, Makiko Itami, Miki Ohira, Hiroki Nagase, Keizo Takenaga, and Jun-Ichi Hayashi
- Journal Title
  
  Proc. Natl. Acad. Sci
  
  Volume: (in Press)
- NAID
  120004442319
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19100007
[Journal Article] Mitochondrial DNA mutations regulate metastasis of human breast cancer cells2011
- Author(s)
  Hirotake Imanishi, Keisuke Hattori, Reiko Wada, Kaori Ishikawa, Sayaka Fukuda, Keizo Takenaga, Kazuto Nakada, and Jun-Ichi Hayashi
- Journal Title
  
  PLoS One
  
  Volume: 6
- NAID
  120003386772
- URL
  https://www.tulips.tsukuba.ac.jp/dspace/handle/2241/114066
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19100007
[Journal Article] The innate immune system in host mice targets cells with allogenic mitochondrial DNA2010
- Author(s)
  Kaori Ishikawa, Noriko Toyama-Sorimachi, Kazuto Nakada, Mami Morimoto, Hirotake Imanishi, Mariko Yoshizaki, Shigemi Sasawatari, Mamoru Niikura, Keizo Takenaga, Hiromichi Yonekawa, and Jun-Ichi Hayashi
- Journal Title
  
  J Exp. Med
  
  Volume: 207 Pages: 2297-2305
- NAID
  120002771201
- URL
  https://www.tulips.tsukuba.ac.jp/dspace/handle/2241/107854
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19100007
[Journal Article] Global imaging of mitochondrial morphology in tissues using transgenic mice expressing mitochondrially targeted enhanced green fluorescent protein2010
- Author(s)
  Hiroshi Shitara, Midori Shimanuki, Jun-Ichi Hayashi, Hiromichi Yonekawa
- Journal Title
  
  Exp. Anim. 59
  
  Pages: 99-103
- NAID
  10027852751
- Data Source
  KAKENHI-PROJECT-19100007
[Journal Article] Generation of trans-mitochondrial mito-mice by the introduction of a pathogenic G13997A mtDNA from highly metastatic lung carcinoma cells2010
- Author(s)
  Mutsumi Yokota, Hiroshi Shitara, Osamu Hashizume, Kaori Ishikawa, Kazuto Nakada, Rie Ishii, Choji Taya, Keizo Takenaga, Hiromichi Yonekawa, and Jun-Ichi Hayashi
- Journal Title
  
  FEBS Lett
  
  Volume: 84 Pages: 3943-3948
- URL
  https://www.tulips.tsukuba.ac.jp/dspace/handle/2241/106654
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19100007
[Journal Article] Reactive oxygen species-generating mitochondrial DNA mutation up-regulates hypoxia-inducible factor-1alpha gene transcription via phosphatidylinositol3-kinase-Akt/protein kinase C/histone deacetylase pathway2009
- Author(s)
  Nobuko Koshikawa, Jun-Ichi Hayashi, Akira Nakagawara, and Keizo Takenaga
- Journal Title
  
  J. Biol. Chem
  
  Volume: 284 Pages: 33185-33194
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19100007
[Journal Article] がん転移ミトコンドリア原因説2009
- Author(s)
  石川香、林純一
- Journal Title
  
  蛋白質核酸酵素 54
  
  Pages: 40-48
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19100007
[Journal Article] Reactive oxygen species-generating mitochondrial DNA mutation up-regulates hypoxia-inducible factor-1a gene transcription via phosphatidylinositol 3-kinase-Akt/protein kinase C/histone deacetylase pathway2009
- Author(s)
  Nobuko Koshikawa, Jun-Ichi Hayashi, Akira Nakagawara, Keizo Takenaga
- Journal Title
  
  J. Biol. Chem. 284
  
  Pages: 33185-33194
- Data Source
  KAKENHI-PROJECT-19100007
[Journal Article] New evidence confirms that the mitochondrial bottleneck is generated without reduction of mitochondrial DNA content in early peimordial germ cells of mice2009
- Author(s)
  Liqin Cao, Hiroshi Shitara, Michihiko Sugimoto, Kuniya Abe, Jun-Ichi Hayashi, Hiromichi Yonekawa
- Journal Title
  
  PLoS Genet 5
- Data Source
  KAKENHI-PROJECT-19100007
[Journal Article] 特集:突然変異がん研究最前線:がん転移とミトコンドリアDNA突然変異2009
- Author(s)
  林純一
- Journal Title
  
  金沢工業大学広報誌「Back Up」 28
  
  Pages: 36-39
- Data Source
  KAKENHI-PROJECT-19100007
[Journal Article] がん転移ミトコンドリア原因説2009
- Author(s)
  石川香, 林純一
- Journal Title
  
  蛋白質核酸酵素 54
  
  Pages: 40-48
- Data Source
  KAKENHI-PROJECT-19100007
[Journal Article] Reactive oxygen speciesgenerating mitochondrial DNA mutation up-regulates hypoxia-inducible factor-1 alpha gene transcription via phosphatid ylinositol 3-kinase-Akt/protein kinase C/histone deacetylase pathway2009
- Author(s)
  Koshikawa N, Hayashi J, Nakagawara A, Takenaga K
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 284 Pages: 33185-33194
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590349
[Journal Article] がんとミトコンドリアDNAの関係2009
- Author(s)
  林純一
- Journal Title
  
  理科通信サイエンスネット(数研出版株式会社) 36
  
  Pages: 2-5
- Data Source
  KAKENHI-PROJECT-19100007
[Journal Article] Reactive oxygen species-generating mitochondrial DNA mutation up-regulates hypoxia-inducible factor-lalpha gene transcription via phosphatidylinositol 3-kinase-Akt/protein kinase C/histone deacetylase pathway2009
- Author(s)
  Koshikawa N, Hayashi J, Nakagawara A, Takenaga K
- Journal Title
  
  Joarnal of Biological Chemistry 284
  
  Pages: 33185-33194
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590349
[Journal Article] ミトコンドリアゲノムに起因するエネルギー代謝異常と病態発症2008
- Author(s)
  中田和人、林純一
- Journal Title
  
  実験医学 26
  
  Pages: 2060-2066
- Data Source
  KAKENHI-PROJECT-19100007
[Journal Article] エネルギー代謝ネットワーク中枢の実像に迫る2008
- Author(s)
  林純一、中田和人
- Journal Title
  
  実験医学 26
  
  Pages: 2042-2046
- Data Source
  KAKENHI-PROJECT-19100007
[Journal Article] Enhanced glycolysis induced by mtDNA mutations does not regulate metastasis2008
- Author(s)
  Kaori Ishikawa, Osamu Hashizume, Nobuko Koshikawa, Sayaka Fukuda, Kazuto Nakada, Keizo Takenaga, and Jun-Ichi Hayashi
- Journal Title
  
  FEBS Lett
  
  Volume: 582 Pages: 3525-3350
- NAID
  120000994544
- URL
  https://www.tulips.tsukuba.ac.jp/dspace/handle/2241/101219
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19100007
[Journal Article] ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis2008
- Author(s)
  Kaori Ishikawa, Keizo Takenaga, Miho Akimoto, Nobuko Koshikawa, Aya Yamaguchi, Hirotake Imanishi, Kazuto Nakada, Yoshio Honma, and Jun-Ichi Hayashi
- Journal Title
  
  Science
  
  Volume: 320 Pages: 661-664
- NAID
  120001086852
- URL
  https://www.tulips.tsukuba.ac.jp/dspace/handle/2241/101575
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19100007
[Journal Article] ROS-generating mitochondrial DNA mutations can regulate tumor cellmetastasis2008
- Author(s)
  N, Yamaguchi A, Imanishi H, Nakada K, Honma Y, Hayashi JI
- Journal Title
  
  Science (In press)
- NAID
  120001086852
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19100007
[Journal Article] Pathogenic mitochondrial DNA-induced respiration defects in hematopoietic cells result in anemia by suppressing erythroid differentiation2007
- Author(s)
  Shin-Ichi Inoue, Mutsumi Yokota, Kazuto Nakada, Hiroyuki Miyoshi, Jun-Ichi Hayashi
- Journal Title
  
  FEBS Lett 581
  
  Pages: 1910-1916
- Data Source
  KAKENHI-PROJECT-19100007
[Journal Article] Deletion-mutant mtDNA increases in somatic tissues but decreases in female germ cells with age2007
- Author(s)
  Akitsugu Sato, Kazuto Nakada, Hiroshi Shitara, Atsuko Kasahara, Hitomichi Yonekawa, and Jun-Ichi Hayashi
- Journal Title
  
  Geneics
  
  Volume: 177 Pages: 2031-2037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19100007
[Journal Article] Pathogenic mitochondrial DNA-induced respiration defects in hematopoietic cells result in anemia by suppressing erythroid differentiation2007
- Author(s)
  Shin-Ichi Inoue, Mutsumi Yokota, Kazuto Nakada, Hiroyuki Miyoshi, and Jun-Ichi Hayashi
- Journal Title
  
  FEBS Lett
  
  Volume: 581 Pages: 1910-1906
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19100007
[Journal Article] The mitochondrial bottleneck occurs without reduction of mtDNA content in female mouse germ cells2007
- Author(s)
  Liqin Cao, Hiroshi Shitara, Takuro Horii, Yasumitsu Nagao, Hiroshi Imai, Kuniya Abe, Takahiko Hara, Jun-Ichi Hayashi, and Hiromichi Yonekawa
- Journal Title
  
  Nat. Genet
  
  Volume: 39 Pages: 386-390
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19100007
[Journal Article] The mitochondrial bottleneck occurs without reduction of mtDNA content in female mouse germ cells.2007
- Author(s)
  Cao L, Shitara H, Horii T, Nagao Y, Imai H, Abe K, Hara T, Hayashi J, Yonekawa H.
- Journal Title
  
  Nat Genet. 39(3)
  
  Pages: 386-90
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14GS0305
[Journal Article] The mitochondrial bottleneck occurs without reduction of mtDNA content in female mouse germ cells2007
- Author(s)
  Cao L, Shitara H, Horii T, Nagao Y, Imai H, Abe K, Hara T, Hayashi J, Yonekawa H.
- Journal Title
  
  Nat Genet 39(3)
  
  Pages: 386-90
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14GS0305
[Journal Article] The mitochondrial bottleneck occurs without reduction of mtDNA content in female mouse germ cells.2007
- Author(s)
  Cao L, Shitara H, Horii T, Nagao Y, Imai H, Abe K, Hara T, Hayashi J, Yonekawa H.
- Journal Title
  
  Nat Gent. 39(3)
  
  Pages: 386-90
- Data Source
  KAKENHI-PROJECT-14GS0305
[Journal Article] The mitochondrial bottleneck occurs without reduction of mtDNA content in female mouse germ cells.2007
- Author(s)
  Liqin Cao, Jyunichi Hayashi et al.
- Journal Title
  
  Nat Genet. 39(3)
  
  Pages: 386-390
- Data Source
  KAKENHI-PROJECT-14035101
[Journal Article] The mitochondrial bottleneck occurs without reduction of mtDNA content in female mouse germ cells2007
- Author(s)
  Cao L, Shitara H, Horii T, Nagao Y, Imai I, Abe K, Hara T, Hayashi JI, Yonekawa H
- Journal Title
  
  Nature Genetis 39
  
  Pages: 386-390
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19100007
[Journal Article] Deletion-mutant mtDNA increases in somatic tissues but decreases in female germcells with age2007
- Author(s)
  Akitsugu Sato, Kazuto Nakada, Hiroshi Shitara, Atsuko Kasahara, Hiromichi Yonekawa, Jun-Ichi Hayashi
- Journal Title
  
  Genetics 177
  
  Pages: 2031-2037
- Data Source
  KAKENHI-PROJECT-19100007
[Journal Article] Pathogenic mitochondrial DNA-induced resporation defects in hematopoietic cells result in anemia by suppressing erythroid2007
- Author(s)
  Inoue SI, Yokota M, Nakada K, Miyoshi H, Hayashi JI
- Journal Title
  
  FEBS Lett. 581
  
  Pages: 1910-1916
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19100007
[Journal Article] Mitochondria-related male infertility.2006
- Author(s)
  Kazuto Nakada, Jyunichi Hayashi et al.
- Journal Title
  
  Proc Natl Acad Sci U S A. 103(41)
  
  Pages: 15148-15153
- Data Source
  KAKENHI-PROJECT-14035101
[Journal Article] 哺乳類ミトコンドリアDNAにおける組換え2006
- Author(s)
  佐藤晃嗣, 林純一
- Journal Title
  
  細胞工学 25
  
  Pages: 54-59
- Data Source
  KAKENHI-PROJECT-14GS0305
[Journal Article] 動物モデルと治療戦略 : ミトコンドリア病の動物モデル2006
- Author(s)
  笠原敦子, 林純一
- Journal Title
  
  Clinical Neuroscience 印刷中
- Data Source
  KAKENHI-PROJECT-14GS0305
[Journal Article] Suppression of disease phenotypes of adult mito-mice carrying pathogenic mtDNA by bone marrow transplantation2006
- Author(s)
  Inoue S, Ishikawa K, Nakada K, Sato A, Miyoshi H, Hayashi J.
- Journal Title
  
  Hum Mol Genet 15(11)
  
  Pages: 1801-7
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14GS0305
[Journal Article] Suppression of disease phenotypes of adult mito-mice carrying pathogenic mtDNA by bone marrow transplantation.2006
- Author(s)
  Inoue S, Ishikawa K, Nakada K, Sato A, Miyoshi H, Hayashi J.
- Journal Title
  
  Hum Mol Genet. 15(11), 1
  
  Pages: 801-7
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14GS0305
[Journal Article] 動物モデルと治療戦略:ミトコンドリア病の動物モデル2006
- Author(s)
  笠原敦子, 林純一
- Journal Title
  
  Clinical Neuroscience (印刷中)
- Data Source
  KAKENHI-PROJECT-14035101
[Journal Article] ミトコンドリア病モデルマウスを用いた受精卵遺伝子治療2006
- Author(s)
  佐藤晃嗣, 林純一
- Journal Title
  
  実験医学 24
  
  Pages: 842-845
- Data Source
  KAKENHI-PROJECT-14GS0305
[Journal Article] Mitochondria dynamics and aging2006
- Author(s)
  Akitsugu Sato, Junichi Hayashi
- Journal Title
  
  Biochim.Biophys.Acta (in press)
- Data Source
  KAKENHI-PROJECT-14035101
[Journal Article] 哺乳類ミトコンドリアDNAにおける組換え2006
- Author(s)
  佐藤晃嗣, 林純一
- Journal Title
  
  細胞工学 25
  
  Pages: 54-59
- Data Source
  KAKENHI-PROJECT-14035101
[Journal Article] Mitochondria dynamics and aging2006
- Author(s)
  Akitsugu Sato, Jyunichi Hayashi
- Journal Title
  
  Biochim. Biophys. Acta in press
- Data Source
  KAKENHI-PROJECT-14GS0305
[Journal Article] Generation of trans-mitochondrial mice carrying homoplasmic mtDNA with a missense mutation in a structural gene using ES cells2006
- Author(s)
  Atsuko Kasahara, Jyunichi Hayashi
- Journal Title
  
  Hum. Mol. Genet. 15
  
  Pages: 871-881
- Data Source
  KAKENHI-PROJECT-14GS0305
[Journal Article] Generation of trans-mitochondrial mice carrying homoplasmlc mtDNA with a missense mutation in a structural gene using ES cells2006
- Author(s)
  Atsuko Kasahara, Junichi Hayashi
- Journal Title
  
  Hum.Mol.Genet. 15
  
  Pages: 871-881
- Data Source
  KAKENHI-PROJECT-14035101
[Journal Article] Generation of trans-mitochondrial mice carrying homoplasmic mtDNAs with a missense mutation in a structural gene using ES cells2006
- Author(s)
  Kasahara A, Ishikawa K, Yamaoka M, Ito M, Watanabe N, Akimoto M, Sato A, Nakada K, Endo H, Suda Y, Aizawa S, Hayashi J.
- Journal Title
  
  Hum Mol Genet 15(6)
  
  Pages: 871-81
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14GS0305
[Journal Article] Mitochondria-related male infertility.2006
- Author(s)
  Nakada K, Sato A, Yoshida K, Morita T, Tanaka H, Inoue S, Yonekawa H, Hayashi J.
- Journal Title
  
  Proc Natl Acad Sci U S A. 103(41)
  
  Pages: 15148-53
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14GS0305
[Journal Article] Mitochondria-related male infertility2006
- Author(s)
  Nakada K, Sato A, Yoshida K, Morita T, Tanaka H, Inoue S, Yonekawa H, Hayashi J.
- Journal Title
  
  Proc Natl Acad Sci U S A. 103(41)
  
  Pages: 15148-53
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14GS0305
[Journal Article] ミトコンドリア病モデルマウスを用いた受精卵遺伝子治療2006
- Author(s)
  佐藤晃嗣, 林純一
- Journal Title
  
  実験医学 24
  
  Pages: 842-845
- Data Source
  KAKENHI-PROJECT-14035101
[Journal Article] Generation of trans-mitochondrial mice carrying homoplasmic mtDNAs with a missense mutation in a structural gene using ES cells.2006
- Author(s)
  Kasahara A, Ishikawa K, Yamaoka M, Ito M, Watanabe N, Akimoto M, Sato A, Nakada K Endo H, Suda Y, Aizawa S, Hayashi J.
- Journal Title
  
  Mol Genet. 15(6)
  
  Pages: 871-81
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14GS0305
[Journal Article] Suppression of disease phenotypes of adult mito-mice carrying pathogenic mtDNA by bone marrow transplantation.2006
- Author(s)
  Inoue S, Ishikawa K, Nakada K, Sato A, Miyoshi H, Hayashi J.
- Journal Title
  
  Hum Mol Genet. 15(11)
  
  Pages: 1801-7
- Data Source
  KAKENHI-PROJECT-14GS0305
[Journal Article] Suppression of disease phenotypes of adult mito-mice carrying pathogenic mtDNA by bone marrow transplantation.2006
- Author(s)
  Shin-ichi Inoue, Jyunichi Hayashi et al.
- Journal Title
  
  Hum Mol Genet. 15(11)
  
  Pages: 1801-1807
- Data Source
  KAKENHI-PROJECT-14035101
[Journal Article] Rare creation of recombinant mtDNA haplotypes in mammalian tissues2005
- Author(s)
  Sato A, Nakada K, Akimoto M, Ishikawa K, Ono T, Shitara H, Yonekawa H, Hayashi J.
- Journal Title
  
  Proc Natl Acad Sci U S A. 102(17)
  
  Pages: 6057-62
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14GS0305
[Journal Article] Nuclear DNA but not mtDNA controls tumor phenotypes in mouse cells.2005
- Author(s)
  Miho Akimoto, Junichi Hayashi
- Journal Title
  
  Biochem.Biophys.Res.Commun. 327
  
  Pages: 1028-1035
- Data Source
  KAKENHI-PROJECT-14035101
[Journal Article] 動物ミトコンドリアゲノムのテクノロジー:ミトコンドリア移植による病原性ミトコンドリアDNAの診断2005
- Author(s)
  石川香, 林純一
- Journal Title
  
  蛋白質核酸酵素 50
  
  Pages: 1904-1906
- Data Source
  KAKENHI-PROJECT-14035101
[Journal Article] 哺乳類ミトコンドリアゲノムの遺伝と進化;ミトコンドリアDNAの母性遺伝と組換え2005
- Author(s)
  佐藤晃嗣, 林純一
- Journal Title
  
  蛋白質核酸酵素 50
  
  Pages: 1744-1748
- Data Source
  KAKENHI-PROJECT-14035101
[Journal Article] ミトマウスを用いた糖尿病発症における変異型ミトコンドリアゲノムの病原性の検証2005
- Author(s)
  中田和人, 林純一
- Journal Title
  
  細胞工学 24
  
  Pages: 820-824
- Data Source
  KAKENHI-PROJECT-14GS0305
[Journal Article] Application of ES cells for generation of respiration-deficient mice carrying mtDNA with a large-scale deletion.2005
- Author(s)
  Kaori Ishikawa, Jyunichi Hayashi
- Journal Title
  
  Biochem. Biophys. Res. Commun. 333
  
  Pages: 590-595
- Data Source
  KAKENHI-PROJECT-14GS0305
[Journal Article] Rare creation of recombinant mtDNA haplotypes in mammalian somatic tissues.2005
- Author(s)
  Akitsugu Sato, Jyunichi Hayashi
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 102
  
  Pages: 6057-6062
- Data Source
  KAKENHI-PROJECT-14GS0305
[Journal Article] オルガネラダイナミックス研究の実態と展望2005
- Author(s)
  坂本亘, 林純一
- Journal Title
  
  蛋白質核酸酵素 50
  
  Pages: 1861-1862
- Data Source
  KAKENHI-PROJECT-14GS0305
[Journal Article] 動物オルガネラダイナミックス:ミトコンドリアゲノムの相補作用2005
- Author(s)
  佐藤晃嗣, 林純一
- Journal Title
  
  蛋白質核酸酵素 50
  
  Pages: 1863-1867
- Data Source
  KAKENHI-PROJECT-14035101
[Journal Article] 動物ミトコンドリアゲノムのテクノロジー : 生きているGFPミトコンドリアの長期観察2005
- Author(s)
  設楽浩志, 林純一
- Journal Title
  
  蛋白質核酸酵素 50
  
  Pages: 1909-1911
- Data Source
  KAKENHI-PROJECT-14GS0305
[Journal Article] Gene therapy for progeny of mito-mice carrying pathogenic mtDNA by nuclear transplantation2005
- Author(s)
  Akitsugu Sato, Jyunichi Hayashi
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 102
  
  Pages: 16765-16770
- Data Source
  KAKENHI-PROJECT-14035101
[Journal Article] Application of ES cells for generation of respiration-deficient mice carrying mtDNA with a large-scale deletion.2005
- Author(s)
  Kaori Ishikawa, Junichi Hayashi
- Journal Title
  
  Biochem.Biophys.Res.Commun. 333
  
  Pages: 590-595
- Data Source
  KAKENHI-PROJECT-14035101
[Journal Article] ミトコンドリアDNA変異の機能的評価:サイブリッド作製2005
- Author(s)
  石川香, 林純一
- Journal Title
  
  臨床検査 49
  
  Pages: 51-58
- Data Source
  KAKENHI-PROJECT-14035101
[Journal Article] 哺乳類ミトコンドリアゲノムの変異と疾患 : ミトコンドリア遺伝子病モデルマウス2005
- Author(s)
  中田和人, 林純一
- Journal Title
  
  蛋白質核酸酵素 50
  
  Pages: 1774-1777
- Data Source
  KAKENHI-PROJECT-14GS0305
[Journal Article] 哺乳類ミトコンドリアゲノムの変異と疾患;ミトコンドリア遺伝子病モデルマウス2005
- Author(s)
  中田和人, 林純一
- Journal Title
  
  蛋白質核酸酵素 50
  
  Pages: 1774-1777
- Data Source
  KAKENHI-PROJECT-14035101
[Journal Article] Rare creation of recombinant mtDNA haplotypes in mammalian tissues.2005
- Author(s)
  Sato A, Nakada K, Akimoto M, Ishikawa K, Ono T, Shitara H, Yonekawa H, Hayashi J.
- Journal Title
  
  Proc Natl Acad Sci U S A. 102(17)
  
  Pages: 6057-62
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14GS0305
[Journal Article] Nuclear DNA but not mtDNA controls tumor phenotypes in mouse cells.2005
- Author(s)
  Miho Akimoto, Jyunichi Hayashi
- Journal Title
  
  Biochem. Biophys. Res. Commun. 327
  
  Pages: 1028-1035
- Data Source
  KAKENHI-PROJECT-14GS0305
[Journal Article] ミトコンドリア DNA 変異の機能的評価 : サイブリッド作製2005
- Author(s)
  石川香, 林純一
- Journal Title
  
  臨床検査 49
  
  Pages: 51-58
- Data Source
  KAKENHI-PROJECT-14GS0305
[Journal Article] Rare creation of recombinant mtDNA haplotypes in mammalian somatic tissues.2005
- Author(s)
  Akitsugu Sato, Jyunichi Hayashi
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 102
  
  Pages: 6057-6062
- Data Source
  KAKENHI-PROJECT-14035101
[Journal Article] Gene therapy for progeny of mito-mice carrying pathogenic mtDNA by nuclear transplantation2005
- Author(s)
  Sato A, Kono T, Nakada K, Ishikawa K, Inoue S, Yonekawa H, Hayashi J.
- Journal Title
  
  Proc Natl Acad Sci U S A. 102(46)
  
  Pages: 16765-70
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14GS0305
[Journal Article] 動物オルガネラダイナミックス : ミトコンドリアゲノムの相補作用2005
- Author(s)
  佐藤晃嗣, 林純一
- Journal Title
  
  蛋白質核酸酵素 50
  
  Pages: 1863-1867
- Data Source
  KAKENHI-PROJECT-14GS0305
[Journal Article] ミトマウスを用いた糖尿病発症における変異型ミトコンドリアゲノムの病原性の検証2005
- Author(s)
  中田和人, 林純一
- Journal Title
  
  細胞工学 24
  
  Pages: 820-824
- Data Source
  KAKENHI-PROJECT-14035101
[Journal Article] 動物ミトコンドリアゲノムのテクノロジー:生きているGFPミトコンドリアの長期観察2005
- Author(s)
  設楽浩志, 林純一
- Journal Title
  
  蛋白質核酸酵素 50
  
  Pages: 1909-1911
- Data Source
  KAKENHI-PROJECT-14035101
[Journal Article] オルガネラダイナミックス研究の現状と展望2005
- Author(s)
  坂本亘, 林純一
- Journal Title
  
  蛋白質核酸酵素 50
  
  Pages: 1861-1862
- Data Source
  KAKENHI-PROJECT-14035101
[Journal Article] Gene therapy for progeny of mito-mice carrying pathogenic mtDNA by nuclear transplantation2005
- Author(s)
  Akitsugu Sato, Jyunichi Hayashi
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 102
  
  Pages: 16765-16770
- Data Source
  KAKENHI-PROJECT-14GS0305
[Journal Article] Gene therapy for progeny of mito-mice carrying pathogenic mtDNA by nuclear transplantation.2005
- Author(s)
  Sato A, Kono T, Nakada K, Ishikawa K, Inoue S, Yonekawa H, Hayashi J.
- Journal Title
  
  Proc Natl Acad Sci U S A. 102(46)
  
  Pages: 16765-70
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14GS0305
[Journal Article] 哺乳類ミトコンドリアゲノムの遺伝と進化;ミトコンドリアDNAの母性遺伝と組換え2005
- Author(s)
  佐藤晃嗣, 林純一
- Journal Title
  
  蛋白質核酸酵素 50
  
  Pages: 1744-1748
- Data Source
  KAKENHI-PROJECT-14GS0305
[Journal Article] 哺乳類ミトコンドリアゲノムの遺伝と進化:オーバービュー2005
- Author(s)
  林純一
- Journal Title
  
  蛋白質核酸酵素 50
  
  Pages: 1742-1743
- Data Source
  KAKENHI-PROJECT-14035101
[Journal Article] 哺乳類ミトコンドリアゲノムの遺伝と進化;オーバービュー2005
- Author(s)
  林純一
- Journal Title
  
  蛋白質核酸酵素 50
  
  Pages: 1742-1743
- Data Source
  KAKENHI-PROJECT-14GS0305
[Journal Article] 動物ミトコンドリアゲノムのテクノロジー : ミトコンドリア移植による病原性ミトコンドリアDNAの診断2005
- Author(s)
  石川香, 林純一
- Journal Title
  
  蛋白質核酸酵素 50
  
  Pages: 1904-1906
- Data Source
  KAKENHI-PROJECT-14GS0305
[Journal Article] Mitochondria Mystery2002
- Author(s)
  Jun-Ichi Hayashi
- Pages
  1-297
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14035101
[Presentation] Establishment of novel model mice for mitochondrial tRNA-based disorders2018
- Author(s)
  Haruna Tani, Kaori Ishikawa, Jun-Ichi Hayashi, Kazuto Nakada
- Organizer
  The 11th Japan-China-Korea Graduate Student Forum
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02463
[Presentation] Generation of mice carrying pathogenic mitochondrial DNA with a point mutation in tRNALeu(UUR) gene2018
- Author(s)
  Haruna Tani, Kaori Ishikawa, Akinori Shimizu, Takayuki Mito, Jun-Ichi Hayashi, Kazuto Nakada
- Organizer
  The 1st International Mitochondria Meeting for Young Scientists
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02463
[Presentation] ミトコンドリアtRNAに点突然変異を有する新規ミトコンドリア病モデルマウスの樹立へ向けて2018
- Author(s)
  谷春菜、石川香、林純一、中田和人
- Organizer
  第18回日本ミトコンドリア学会年会
- Data Source
  KAKENHI-PROJECT-16H02463
[Presentation] 母性遺伝するミトコンドリアゲノムと老化関連疾患～ミトコンドリアと子宮内膜症の関連～2017
- Author(s)
  林　純一
- Organizer
  第69回日本産科婦人科学会核術集会
- Invited
- Data Source
  KAKENHI-PROJECT-16H02463
[Presentation] ミトコンドリアゲノムの突然変異が老化やがん化等の原因になるという神話2016
- Author(s)
  林　純一
- Organizer
  第27回新薬創製談話会
- Place of Presentation
  筑波山江戸屋（茨城県・つくば市）
- Year and Date
  2016-08-30
- Invited
- Data Source
  KAKENHI-PROJECT-16H02463
[Presentation] 教科書神話の賞味期限ー正解のない生物学の世界は楽しいー2016
- Author(s)
  林　純一
- Organizer
  第11回　SATつくばスタイル交流会
- Place of Presentation
  つくば国際会議場中ホール300（茨城県・つくば市）
- Year and Date
  2016-11-23
- Invited
- Data Source
  KAKENHI-PROJECT-16H02463
[Presentation] mtDNAに病原性突然変異を有する新規ミトコンドリア病モデルマウスの作出2016
- Author(s)
  谷春菜、石川香、清水章文、三藤崇行、林純一、中田和人
- Organizer
  日本分子生物学会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Data Source
  KAKENHI-PROJECT-16H02463
[Presentation] ミトコンドリアコードのtRNAに病原性突然変異を有するミトコンドリア病モデルマウスの作出及び病態解析2015
- Author(s)
  清水章文、三藤崇行、榎俊慧、小笠原絵美、橋爪脩、長島瑠子、石川香、中田和人、林純一
- Organizer
  第38回日本分子生物学会年会・第88回日本生化学会大会合同大会（BMB2015）
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-25250011
[Presentation] マウスミトコンドリアDNAの突然変異がコントロールする表現型～核外ゲノムの変異によるインパクト～2015
- Author(s)
  石川香、橋爪脩、清水章文、三藤崇行、中田和人、林純一
- Organizer
  第38回日本分子生物学会年会・第88回日本生化学会大会合同大会（BMB2015）
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2015-12-03
- Invited
- Data Source
  KAKENHI-PROJECT-25250011
[Presentation] 老化ミトコンドリア原因説の検証とその再構築2015
- Author(s)
  三藤崇行、橋爪脩、大西彩紀子、清水章文、石川香、中田和人、林純一
- Organizer
  第38回日本分子生物学会年会・第88回日本生化学会大会合同大会（BMB2015）
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-25250011
[Presentation] 突然変異型ミトコンドリアゲノムの病原性制御～ミトコンドリア・ダイナミクスの関与2014
- Author(s)
  中田和人、石原直忠、林純一
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2014-10-18
- Invited
- Data Source
  KAKENHI-PROJECT-25250011
[Presentation] Reverse Genetic Studies on Mutant Mitochondrial Genomes in Mice2013
- Author(s)
  Nakada K, Hayashi J
- Organizer
  The 4th International Symposium on Dynamics of Mitochondria
- Place of Presentation
  Okinawa Zanpamisaki Royal Hotel, Okinawa, Japan
- Invited
- Data Source
  KAKENHI-PUBLICLY-24117503
[Presentation] Reverse Genetic Studies on Mutant Mitochondrial Genomes in Mice2013
- Author(s)
  Nakada K, Hayashi J
- Organizer
  The 4th International Symposium on Dynamics of Mitochondria
- Place of Presentation
  Okinawa Zanpamisaki Royal Hotel, Okinawa, Japan
- Invited
- Data Source
  KAKENHI-PROJECT-25250011
[Presentation] 大会長講演：ミトコンドリアミステリー：０＋０＝１2012
- Author(s)
  林純一
- Organizer
  第１２回日本ミトコンドリア学会年会
- Place of Presentation
  筑波大学
- Year and Date
  2012-12-20
- Invited
- Data Source
  KAKENHI-PUBLICLY-24117503
[Presentation] シンポジウム:病原性突然変異型ミトコンドリアゲノム導入マウス(ミトマウス)を用いた老化研究2009
- Author(s)
  林純一
- Organizer
  第56回日本実験動物学会総会
- Place of Presentation
  さいたま市(大宮ソニックシティ)
- Year and Date
  2009-05-16
- Data Source
  KAKENHI-PROJECT-19100007
[Presentation] 特別講演:ミトコンドリアDNA突然変異とがん転移能2009
- Author(s)
  林純一
- Organizer
  第28回分子病理学研究会
- Place of Presentation
  神戸市(スペースアルファー神戸)
- Year and Date
  2009-07-18
- Data Source
  KAKENHI-PROJECT-19100007
[Presentation] 特別講演:ミトコンドリアDNA突然変異とがん転移能2009
- Author(s)
  林純一
- Organizer
  第28回分子病理学研究会
- Place of Presentation
  神戸
- Year and Date
  2009-07-19
- Data Source
  KAKENHI-PROJECT-19100007
[Presentation] Symposium : Mitochondrial genome and cellular functions : Mitochondrial bottleneck is not generated by the reduction of mtDNA copy number in mouse female germlines2008
- Author(s)
  Jun-Ichi Hayashi
- Organizer
  第31回日本分子生物学会年会、第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-19100007
[Presentation] The 7th European meeting on mitochondrial pathology (EUROMIT VII) -From basic mechanisms to disease and ageing- Role of mtDNA mutations in metastasis2008
- Author(s)
  Jun-Ichi Hayashi
- Organizer
  City Conference Centre
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2008-06-13
- Data Source
  KAKENHI-PROJECT-19100007
[Presentation] From basic mechanisms to disease and ageing-Role of mtDNA mutations in metastasis City Conference Centre2008
- Author(s)
  Jun-Ichi Hayashi
- Organizer
  The 7th European meeting on mitochondrial pathology (EUROMIT VII)
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2008-06-13
- Data Source
  KAKENHI-PROJECT-19100007
[Presentation] Role of mtDNA mutations in metastasis.2008
- Author(s)
  Hayashi, J.-I.
- Organizer
  The 7th European Meeting on Mitochondrial -Patholog y (Euromit 7)
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2008-06-13
- Data Source
  KAKENHI-PROJECT-19100007
[Presentation] 呼吸鎖酵素複合体Iの機能低下が転移能に及ぼす影響の解析2007
- Author(s)
  石川香、竹永啓三、秋元美穂、越川信子、山口綾、本間良夫、林純一
- Organizer
  第30回分子生物学会年会、第80回日本生化学大合同大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-19100007
[Presentation] Pathogenesis and gene therapy of mice expressing mitochondrial diseases2006
- Author(s)
  Jun-Ichi Hayashi
- Organizer
  30^<th> Aso Symposium
- Place of Presentation
  Aso Prince Hotel
- Year and Date
  2006-07-29
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14035101
[Presentation] シンポジウム「オルガネラDNAの片親遺伝の様式と分子機構」哺乳類ミトコンドリアDNAにおける組換え2006
- Author(s)
  林純一
- Organizer
  日本分子生物学会2006フォーラム
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2006-12-07
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14035101

1. YONEKAWA Hiromichi (30142110)

# of Collaborated Projects: 6 results

# of Collaborated Products: 21 results
2. 香川靖雄 (30048962)

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20. 関口豊三 (70076975)

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23. 岩倉洋一郎 (10089120)

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24. 吉田迪弘 (60001765)

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28. MIYOSHI Hiroyuki

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29. OKAZAKI Yasushi

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30. OHTAKE Akira

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31. MURAYAMA Kei

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38. 木下善仁

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# of Collaborated Products: 1 results
39. 武田充人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
40. 曽田学

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hayashi Jun-Ichi 林 純一

HAYASHI Jun-ichi 林 純一

林 純一 ハヤシ ジュンイチ

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Does age-associated down regulation of human SHMT2 and GCAT genes induce short lifespan or longevity?Principal InvestigatorOngoing

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Investigation of age-associated mitochondrial disorders caused by mtDNA or unknown cytoplasmic genetic elements found in mouse strainsPrincipal Investigator

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Paradigm shift of mammalian mitochondrial genome using intercellular transfer technologyPrincipal Investigator

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核ーミトコンドリアゲノム間の機能的不和合性を導入したモデル生物の作出Principal Investigator

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Comparison of the frequency of mtDNA mutation in primary and metastatic lesions of human malignant tumors

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Analysis of entire physiological roles of mammalian mtDNA by generation of mice carrying various pathogenic mutationsPrincipal Investigator

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Studies on pathogenesis and gene therapy using mice with the mutated mtDNA in tRNA genesPrincipal Investigator

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Application of disease-model mice with mutant mtDNA for precise investigation of its pathogenesisPrincipal Investigator

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ミトコンドリアDNA突然変異導入マウスを用いたミトコンドリアゲノムの基礎遺伝学Principal Investigator

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マウス人工的突然変異tRNA遺伝子導入によるmtDNAノックアウトマウスの作製Principal Investigator

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マウス人工的突然変異tRNA遺伝子導入によるmtDNAノックアウトマウスの作製Principal Investigator

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マウス人工的突然変異tRNA遺伝子導入によるmtDNAノックアウトマウスの作製Principal Investigator

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Generation and application of mtDNA knockout mice as models for mitochondrial diseasesPrincipal Investigator

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Hayashi Jun-Ichi 林純一

HAYASHI Jun-ichi 林純一

林純一ハヤシジュンイチ