Ota Tsuguhito 太田嗣人

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OTA Tsuguhito 太田嗣人

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Researcher Number	60397213
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2017 – 2021: 旭川医科大学, 医学部, 教授 2017 – 2018: 金沢大学, 先進予防医学研究センター, 准教授 2013 – 2016: 金沢大学, 脳・肝インターフェースメディシン研究センター, 准教授 2015: 金沢大学, 脳・肝インターフェースメディスン研究センター, 准教授 2008 – 2011: Kanazawa University, フロンティアサイエンス機構, 特任助教
Review Section/Research Field	Principal Investigator Eating habits / Metabolomics / Basic Section 59040:Nutrition science and health science-related / Applied health science Except Principal Investigator Basic Section 59040:Nutrition science and health science-related / Basic Section 53050:Dermatology-related / Gastroenterology
Keywords	Principal Investigator 肥満 / 炎症 / インスリン抵抗性 / 脂肪肝 / 糖尿病 / 褐色脂肪 / 機能性食品 / エネルギー代謝 / NASH / マクロファージ … More / 肝臓 / スルフォラファン / グルコラファニン / NAFLD / 腸内細菌 / 褐色脂肪組織 / スフィンゴシン１リン酸 / 肝がん / 非アルコール性脂肪肝炎 / スフィンゴシンキナーゼ / 機能性脂質 / カロテノイド / アスタキサンチン / β-クリプトキサンチン / 脂肪組織 / ケモカイン / インリン抵抗性 / 非アルコール性脂肪肝炎(NASH) / 脂質代謝 / 小胞体ストレス / 脂質代謝異常 … More Except Principal Investigator スルフォラファン / 非アルコール性脂肪性肝疾患 / リポ多糖 / ノトバイオート / 加齢 / 糖尿病 / 短鎖脂肪酸 / アクアポリン / 皮膚 / 腸内細菌 / 生活習慣病 / 栄養 / 肝臓 / 発現制御 / ゲノム Less

New regulatory mechanisms of skin functional molecules via gut microbiota
- Principal Investigator
  
  IKARASHI NOBUTOMO
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Hoshi University
血中リポ多糖(LPS)管理の非アルコール性脂肪性肝疾患への有用性の検討
- Principal Investigator
  
  玉木陽穂
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Asahikawa Medical College
エネルギー代謝を亢進させる抗肥満機能性食品創出のための基盤研究Principal Investigator
- Principal Investigator
  
  太田嗣人
- Project Period (FY)
  2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Asahikawa Medical College
Research and development for energy expending anti-obesity functional foodPrincipal Investigator
- Principal Investigator
  
  Ota Tsuguhito
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Eating habits
- Research Institution
  Asahikawa Medical College
  Kanazawa University
Elucidating mechanisms specific to NASH-associated HCC developmentPrincipal Investigator
- Principal Investigator
  
  Ota Tsuguhito
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Applied health science
- Research Institution
  Kanazawa University
Study of the liver as an endocrine organ
- Principal Investigator
  
  KANEKO Shuichi
- Project Period (FY)
  2014 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Gastroenterology
- Research Institution
  Kanazawa University
Development of novel pharmacological treatments for nonalcoholic steatohepatitis: an application of carotenoid compoundPrincipal Investigator
- Principal Investigator
  
  Ota Tsuguhito
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Eating habits
- Research Institution
  Kanazawa University
Role of CCR5 and CX3CR1 in the development of insulin resistancePrincipal Investigator
- Principal Investigator
  
  OTA Tsuguhito
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Kanazawa University
Regulation of hepatic glucose and lipid metabolism by ER stress responsePrincipal Investigator
- Principal Investigator
  
  OTA Tsuguhito
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Kanazawa University

[Book] 肥満症・インスリン抵抗性がもたらす肝の炎症シグナル　非アルコール性脂肪性肝疾患（NAFLD/NASH）の最新知見2020
- Author(s)
  太田嗣人
- Total Pages
  6
- Publisher
  日本内科学会
- Data Source
  KAKENHI-PROJECT-19H04047
[Book] NASH/NAFLD Ⅱ章動脈硬化を識る B.危険因子・関連疾患とその予防・治療動脈硬化診療のすべて　日本医師会雑誌148巻特別号(２)2019
- Author(s)
  太田嗣人
- Total Pages
  3
- Publisher
  南江堂
- ISBN
  9784524227556
- Data Source
  KAKENHI-PROJECT-19H04047
[Book] NASH/NAFLDの新知見，インスリン抵抗性改善化合物　肝胆膵2018
- Author(s)
  玉木陽穂，太田嗣人
- Total Pages
  7
- Publisher
  アークメディア
- ISBN
- Data Source
  KAKENHI-PROJECT-16H03035
[Book] 糖尿病薬と肝疾患治療, 糖尿病の最新治療2018
- Author(s)
  坂上英充、太田嗣人
- Total Pages
  6
- Publisher
  BIO Clinica
- ISBN
- Data Source
  KAKENHI-PROJECT-16H03035
[Book] 食品因子による肥満・脂肪肝の予防 FOOD STYLE212018
- Author(s)
  太田嗣人
- Total Pages
  5
- Publisher
  食品化学新聞社
- ISBN
- Data Source
  KAKENHI-PROJECT-16H03035
[Book] スルフォラファンの肥満抑制効果　BIO INDUSTRY2018
- Author(s)
  長田直人　太田嗣人
- Total Pages
  9
- Publisher
  シーエムシー出版
- ISBN
- Data Source
  KAKENHI-PROJECT-16H03035
[Book] インスリン抵抗性改善薬　Ⅳ.NAFLD/NASHの治療学NAFLD/NASH～診断・治療の最新動向2018
- Author(s)
  玉木陽穂，太田嗣人
- Total Pages
  7
- Publisher
  日本臨床
- ISBN
- Data Source
  KAKENHI-PROJECT-16H03035
[Book] 高TG血症に関連する疾患の管理と治療　NASH/NAFLD 最新医学別冊診断と治療のABC1382018
- Author(s)
  竹田安孝、太田嗣人
- Total Pages
  10
- Publisher
  最新医学社
- ISBN
- Data Source
  KAKENHI-PROJECT-16H03035
[Book] CCR5による脂肪組織マクロファージの動態制御―CCR5とインスリン抵抗性　医学のあゆみ2016
- Author(s)
  太田嗣人
- Total Pages
  150
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-PROJECT-16H03035
[Book] 肝臓を大切に－血糖値が気になる人のためのお話－　月刊糖尿病ライフさかえ2016
- Author(s)
  太田嗣人
- Total Pages
  62
- Publisher
  時事通信出版局
- Data Source
  KAKENHI-PROJECT-16H03035
[Book] ビグアナイド薬の効果的な使い方、経口糖尿病治療薬2016－病態に応じたベストチョイス　糖尿病診療マスター2016
- Author(s)
  太田嗣人
- Total Pages
  920
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-15K12698
[Book] ビグアナイド薬の効果的な使い方、経口糖尿病治療薬2016－病態に応じたベストチョイス　糖尿病診療マスター2016
- Author(s)
  太田嗣人
- Total Pages
  920
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-16H03035
[Book] CCR5による脂肪組織マクロファージの動態制御―CCR5とインスリン抵抗性　医学のあゆみ2016
- Author(s)
  太田嗣人
- Total Pages
  150
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-PROJECT-15K12698
[Book] 肝臓を大切に－血糖値が気になる人のためのお話－　月刊糖尿病ライフさかえ2016
- Author(s)
  太田嗣人
- Total Pages
  62
- Publisher
  時事通信出版局
- Data Source
  KAKENHI-PROJECT-15K12698
[Book] 別冊医学のあゆみレドックスUPDATE2015
- Author(s)
  太田嗣人
- Total Pages
  5
- Publisher
  脂肪肝の治療標的としての小胞体ストレス
- Data Source
  KAKENHI-PROJECT-15K12698
[Book] 脂肪肝の治療標的としての小胞体ストレス、別冊医学のあゆみレドックスUPDATE2015
- Author(s)
  太田嗣人
- Total Pages
  5
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-PROJECT-25282017
[Book] 糖尿病研修ノート改訂第２版2014
- Author(s)
  太田嗣人
- Total Pages
  5
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-25282017
[Book] Annual Review 糖尿病・代謝・内分泌20142014
- Author(s)
  太田嗣人
- Total Pages
  213
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-25282017
[Book] 内分泌・糖尿病・代謝内科2014
- Author(s)
  太田嗣人
- Total Pages
  8
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-25282017
[Book] 糖尿病の分子標的と治療薬事典2013
- Author(s)
  太田嗣人
- Total Pages
  343
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-25282017
[Book] 慢性炎症とインスリン抵抗性をリンクするケモカインの役割,メタボリックシンドロームII(後篇)-メタボリックシンドロームの基礎-成因と病態/遺伝子・病態・標的分子の面から:ケモカイン2011
- Author(s)
  太田嗣人
- Total Pages
  13
- Publisher
  最新医学66(6):192-204,2011,最新医学社
- Data Source
  KAKENHI-PROJECT-22790854
[Book] 分子消化器病2009年3月号メタボリックシンドロームから消化器疾患に迫る2008
- Author(s)
  太田嗣人
- Total Pages
  6
- Publisher
  脂質異常症・脂肪肝形成におけるERストレスの意義
- Data Source
  KAKENHI-PROJECT-20790643
[Journal Article] Cannabidiol Application Increases Cutaneous Aquaporin-3 and Exerts a Skin Moisturizing Effect2021
- Author(s)
  Ikarashi Nobutomo、Shiseki Marina、Yoshida Ryotaro、Tabata Keito、Kimura Rina、Watanabe Tomofumi、Kon Risako、Sakai Hiroyasu、Kamei Junzo
- Journal Title
  
  Pharmaceuticals
  
  Volume: 14 Issue: 9 Pages: 879-879
- DOI
  10.3390/ph14090879
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08783
[Journal Article] Wound-Healing and Skin-Moisturizing Effects of Sasa veitchii Extract2021
- Author(s)
  Ikarashi Nobutomo、Kaneko Miho、Fujisawa Izumi、Fukuda Natsuko、Yoshida Ryotaro、Kon Risako、Sakai Hiroyasu、Sugiyama Kiyoshi、Kamei Junzo
- Journal Title
  
  Healthcare
  
  Volume: 9 Issue: 6 Pages: 761-761
- DOI
  10.3390/healthcare9060761
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08783
[Journal Article] Xanthine oxidase inhibition attenuates insulin resistance and diet-induced steatohepatitis in mice2020
- Author(s)
  Nishikawa Tomoki、Nagata Naoto、Shimakami Tetsuro、Shirakura Takashi、Matsui Chieko、Ni Yinhua、Zhuge Fen、Xu Liang、Chen Guanliang、Nagashimada Mayumi、Yamashita Taro、Sakai Yoshio、Yamashita Tatsuya、Mizukoshi Eishiro、Honda Masao、Kaneko Shuichi、Ota Tsuguhito
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 815-815
- DOI
  10.1038/s41598-020-57784-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K11764, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-18H02793, KAKENHI-PROJECT-19H04047
[Journal Article] Adipose Tissue Macrophage Phenotypes and Characteristics: The Key to Insulin Resistance in Obesity and Metabolic Disorders2020
- Author(s)
  Ni Yinhua、Ni Liyang、Zhuge Fen、Xu Liang、Fu Zhengwei、Ota Tsuguhito
- Journal Title
  
  Obesity
  
  Volume: 28 Issue: 2 Pages: 225-234
- DOI
  10.1002/oby.22674
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04047
[Journal Article] Impact of Glucoraphanin-Mediated Activation of Nrf2 on Non-Alcoholic Fatty Liver Disease with a Focus on Mitochondrial Dysfunction2019
- Author(s)
  Xu L、Nagata N、Ota T
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Issue: 23 Pages: 5920-5920
- DOI
  10.3390/ijms20235920
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04047, KAKENHI-PROJECT-18K08506
[Journal Article] Circulating extracellular vesicle‐encapsulated HULC is a potential biomarker for human pancreatic cancer2019
- Author(s)
  Takahashi Kenji、Ota Yu、Kogure Takayuki、Suzuki Yuko、Iwamoto Hidetaka、Yamakita Keisuke、Kitano Yohei、Fujii Satoshi、Haneda Masakazu、Patel Tushar、Ota Tsuguhito
- Journal Title
  
  Cancer Science
  
  Volume: 111 Issue: 1 Pages: 98-111
- DOI
  10.1111/cas.14232
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04047, KAKENHI-PROJECT-17K08971
[Journal Article] Lycopene Alleviates Obesity‐Induced Inflammation and Insulin Resistance by Regulating M1/M2 Status of Macrophages2019
- Author(s)
  Chen Guanliang、Ni Yinhua、Nagata Naoto、Zhuge Fen、Xu Liang、Nagashimada Mayumi、Yamamoto Sayo、Ushida Yusuke、Fuke Nobuo、Suganuma Hiroyuki、Kaneko Shuichi、Ota Tsuguhito
- Journal Title
  
  Molecular Nutrition & Food Research
  
  Volume: 63 Issue: 21 Pages: 1900602-1900602
- DOI
  10.1002/mnfr.201900602
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K11764, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-19H04047
[Journal Article] Pirfenidone prevents and reverses hepatic insulin resistance and steatohepatitis by polarizing M2 macrophages2019
- Author(s)
  Chen Guanliang、Ni Yinhua、Nagata Naoto、Xu Liang、Zhuge Fen、Nagashimada Mayumi、Kaneko Shuichi、Ota Tsuguhito
- Journal Title
  
  Laboratory Investigation
  
  Volume: - Issue: 9 Pages: 1335-1348
- DOI
  10.1038/s41374-019-0255-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05345, KAKENHI-PROJECT-19K11764, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-19H04047
[Journal Article] Lycopene prevents the progression of lipotoxicity-induced nonalcoholic steatohepatitis by decreasing oxidative stress in mice2019
- Author(s)
  Ni Yinhua、Zhuge Fen、Nagashimada Mayumi、Nagata Naoto、Xu Liang、Yamamoto Sayo、Fuke Nobuo、Ushida Yusuke、Suganuma Hiroyuki、Kaneko Shuichi、Ota Tsuguhito
- Journal Title
  
  Free Radical Biology and Medicine
  
  Volume: - Pages: 225-234
- DOI
  10.1016/j.freeradbiomed.2019.11.036
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K11764, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-19H04047
[Journal Article] Unusual manifestations of giant cell arteritis and granulomatosis with polyangiitis2019
- Author(s)
  Yoshimoto Ryota、Tanaka Kitaru、Kawahata Tomoki、Takatori Sayaka、Takatori Kyohei、Eguchi Kohei、Fujishiro Daisuke、Kodama Satoru、Kobayashi Atsushi、Okamoto Kensaku、Yuzawa Sayaka、Ota Tsuguhito、Makino Yuichi
- Journal Title
  
  Immunological Medicine
  
  Volume: 42 Issue: 2 Pages: 94-98
- DOI
  10.1080/25785826.2019.1657377
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04047
[Journal Article] Role of Vitamin E in Nonalcoholic Fatty Liver Disease2019
- Author(s)
  Nagashimada M, Ota T
- Journal Title
  
  IUBMB Life
  
  Volume: 71 Issue: 4 Pages: 516-522
- DOI
  10.1002/iub.1991
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H03035, KAKENHI-PROJECT-15H05345
[Journal Article] Hypoxia-inducible factor-1α is the therapeutic target of the SGLT2 inhibitor for diabetic nephropathy.2019
- Author(s)
  Ryoichi Bessho, Yumi Takiyama, Takao Takiyama, Hiroya Kitsunai, Yasutaka Takeda, Hidemitsu Sakagami, Tsuguhito Ota
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 14754-14754
- DOI
  10.1038/s41598-019-51343-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08718, KAKENHI-PROJECT-19H04047
[Journal Article] Increment of plasma glucose by exogenous glucagon is associated with present and future renal function in type 22019
- Author(s)
  Yasutaka Takeda, Yukihiro Fujita, Ryoichi Bessho, Mao Sato, Tomoe Abe, Tsuyoshi Yanagimachi, Hidemitsu Sakagami, Atsuko Abiko, Yumi Takiyama, Tsuguhito Ota and Masakazu Haneda
- Journal Title
  
  BMC Endocr Disord
  
  Volume: 19 Issue: 1 Pages: 99-99
- DOI
  10.1186/s12902-019-0428-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08718, KAKENHI-PROJECT-19H04047
[Journal Article] Regulation of Gut Microbiota and Metabolic Endotoxemia with Dietary Factors2019
- Author(s)
  Fuke Nobuo、Nagata Naoto、Suganuma Hiroyuki、Ota Tsuguhito
- Journal Title
  
  Nutrients
  
  Volume: 11 Issue: 10 Pages: 2277-2277
- DOI
  10.3390/nu11102277
- NAID
  120006728440
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04047, KAKENHI-PROJECT-18K08506
[Journal Article] Empagliflozin reverses obesity and insulin resistance through fat browning and alternative macrophage activation in mice fed a high-fat diet2019
- Author(s)
  Xu Liang、Nagata Naoto、Chen Guanliang、Nagashimada Mayumi、Zhuge Fen、Ni Yinhua、Sakai Yuriko、Kaneko Shuichi、Ota Tsuguhito
- Journal Title
  
  BMJ Open Diabetes Research & Care
  
  Volume: 7 Issue: 1 Pages: e000783-e000783
- DOI
  10.1136/bmjdrc-2019-000783
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K11764, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-19H04047
[Journal Article] A porcine placental extract prevents steatohepatitis by suppressing activation of macrophages and stellate cells in mice.2018
- Author(s)
  L Xu, N Nagata, M Nagashimada, F Zhuge, Y Ni, G Chen, J Kamei, H Ishikawa, Y Komatsu, S Kaneko, T Ota.
- Journal Title
  
  Oncotarget
  
  Volume: 9 Issue: 19 Pages: 15047-15060
- DOI
  10.18632/oncotarget.24587
- NAID
  120006452383
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-15H05345, KAKENHI-PROJECT-16H03035
[Journal Article] Impacts of Diabetes and an SGLT2 Inhibitor on the Glomerular Number and Volume in db/db Mice, as Estimated by Synchrotron Radiation Micro-CT at SPring-82018
- Author(s)
  Takiyama Y, Sera T, Nakamura M, Ishizeki K, Saijo Y, Yanagimachi T, Maeda M, Bessho R, Takiyama T, Kitsunai H, Sakagami H, Fujishiro D, Fujita Y, Makino Y, Abiko A, Hoshino M, Uesugi K, Yagi N, Ota T, Haneda M
- Journal Title
  
  EBioMedicine
  
  Volume: 36 Pages: 329-346
- DOI
  10.1016/j.ebiom.2018.09.048
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H03035
[Journal Article] Protective effects of astaxanthin on a combination of D-galactose and jet lag-induced aging model in mice2018
- Author(s)
  Ni Y, Wu T, Yang L, Xu Y, Ota T, Fu Z
- Journal Title
  
  Endocr J
  
  Volume: 65 Issue: 5 Pages: 569-578
- DOI
  10.1507/endocrj.EJ17-0500
- NAID
  130007414881
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H03035
[Journal Article] Extracellular vesicle-encapsulated miR-30e suppresses cholangiocarcinoma cell invasion and migration via inhibiting epithelial-mesenchymal transition.2018
- Author(s)
  Ota Y, Takahashi K, Otake S, Tamaki Y, Okada M, Aso K, Makino Y, Fujii S, Ota T, Haneda M
- Journal Title
  
  Oncotarget
  
  Volume: 9 Issue: 23 Pages: 16400-16417
- DOI
  10.18632/oncotarget.24711
- NAID
  120006496817
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H03035
[Journal Article] Prevention of hepatocellular carcinoma by targeting MYCN-positive liver cancer stem cells with acyclic retinoid2018
- Author(s)
  Qin XY, Suzuki H, Honda M, Okada H, Kaneko S, Inoue I, Ebisui E, Hashimoto K, Carninci P, Kanki K, Tatsukawa H, Ishibashi N, Masaki T, Matsuura T, Kagechika H, Toriguchi K, Hatano E, Shirakami Y, Shiota G, Shimizu M, Moriwaki H, Kojima S
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 115 Issue: 19 Pages: 4969-4974
- DOI
  10.1073/pnas.1802279115
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09035, KAKENHI-PROJECT-16K19378, KAKENHI-PROJECT-18K06976, KAKENHI-PROJECT-18K15833, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-18H02793, KAKENHI-PROJECT-16K09352, KAKENHI-PROJECT-16K09353, KAKENHI-PROJECT-17K15933
[Journal Article] Ursodeoxycholic acid potentiates dipeptidyl peptidase-4 inhibitor sitagliptin by enhancing glucagon-like peptide-1 secretion in patients with type 2 diabetes and chronic liver disease: a pilot randomized controlled and add-on study2018
- Author(s)
  K. R. Shima, T. Ota, K. I. Kato, Y. Takeshita, H. Misu, S. Kaneko and T. Takamura
- Journal Title
  
  BMJ Open Diabetes Res Care
  
  Volume: 6 Issue: 1 Pages: e000469-e000469
- DOI
  10.1136/bmjdrc-2017-000469
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09740, KAKENHI-PROJECT-16K19533, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-17H04199, KAKENHI-PROJECT-16H03035
[Journal Article] Glucoraphanin: a broccoli sprout extract that ameliorates obesity-induced inflammation and insulin resistance2018
- Author(s)
  Xu Liang、Nagata Naoto、Ota Tsuguhito
- Journal Title
  
  Adipocyte
  
  Volume: 7 Issue: 3 Pages: 218-225
- DOI
  10.1080/21623945.2018.1474669
- NAID
  120006226752
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08506, KAKENHI-PROJECT-16H03035
[Journal Article] Glucoraphanin ameliorates obesity and insulin resistance through adipose tissue browning and reduction of metabolic endotoxemia in mice.2017
- Author(s)
  Nagata N, Xu L, Kohno S, Ushida Y, Aoki Y, Umeda R, Fuke N, Zhuge F, Ni Y, Nagashimada M, Takahashi C, Suganuma H, Kaneko S and Ota T.
- Journal Title
  
  Diabetes
  
  Volume: 印刷中 Issue: 5 Pages: 1222-1236
- DOI
  10.2337/db16-0662
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01487, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-15H05345, KAKENHI-PROJECT-26290037, KAKENHI-PROJECT-15K00813, KAKENHI-PROJECT-17K19586, KAKENHI-PROJECT-17K14992, KAKENHI-PUBLICLY-17H05615, KAKENHI-PROJECT-16H03035, KAKENHI-PROJECT-17H03576
[Journal Article] Hepatic Transcriptome Profiles of Mice with Diet-Induced Nonalcoholic Steatohepatitis Treated with Astaxanthin and Vitamin E.2017
- Author(s)
  M Kobori, Y Takahashi, M Sakurai, Y Ni, G Chen, M Nagashimada, S Kaneko, T Ota.
- Journal Title
  
  Int J Mol Sci
  
  Volume: 18 Issue: 3 Pages: 593-593
- DOI
  10.3390/ijms18030593
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-16H03035, KAKENHI-PROJECT-15H05345, KAKENHI-PROJECT-15K12698
[Journal Article] Emerging roles of SGLT2 inhibitors in obesity and insulin resistance: Focus on fat browning and macrophage polarization2017
- Author(s)
  Xu L, Ota T
- Journal Title
  
  Adipocyte
  
  Volume: 11 Pages: 1-8
- DOI
  10.1080/21623945.2017.1413516
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H03035
[Journal Article] Peretinoin, an acyclic retinoid, inhibits hepatocarcinogenesis by suppressing sphingosine kinase 1 expression in vitro and in vivo.2017
- Author(s)
  Funaki M, Kitabayashi J, Shimakami T, Nagata N, Sakai Y, Takegoshi K, Okada H, Murai K, Shirasaki T, Oyama T, Yamashita T, Ota T, Takuwa Y, Honda M, Kaneko S.
- Journal Title
  
  Sci Rep
  
  Volume: 7 Issue: 1 Pages: 16978-16978
- DOI
  10.1038/s41598-017-17285-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09413, KAKENHI-PROJECT-16K21058, KAKENHI-PROJECT-17K15933, KAKENHI-PROJECT-15H04673, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-16H03035, KAKENHI-PROJECT-15K08492
[Journal Article] SGLT2 Inhibition by Empagliflozin Promotes Fat Utilization and Browning and Attenuates Inflammation and Insulin Resistance by Polarizing M2 Macrophages in Diet-induced Obese Mice.2017
- Author(s)
  L Xu, N Nagata, M Nagashimada, F Zhuge, Y Ni, G Chen, E Mayoux, S Kaneko, T Ota.
- Journal Title
  
  EBioMedicine
  
  Volume: 20 Pages: 137-149
- DOI
  10.1016/j.ebiom.2017.05.028
- NAID
  120006452382
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-16H03035
[Journal Article] Immune regulation of glucose and lipid metabolism.2017
- Author(s)
  Ota T
- Journal Title
  
  Diabetol Int
  
  Volume: 8 Pages: 257-267
- NAID
  130006187070
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H03035
[Journal Article] Micronutrient Antioxidants and Nonalcoholic Fatty Liver Disease.2016
- Author(s)
  Chen G, Ni Y, Nagata N, Xu L,Ota T.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 17 Issue: 9 Pages: 1-16
- DOI
  10.3390/ijms17091379
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H03035, KAKENHI-PROJECT-15K12698, KAKENHI-PROJECT-16K18700
[Journal Article] Novel Action of Carotenoids on Non-Alcoholic Fatty Liver Disease: Macrophage Polarization and Liver Homeostasis.2016
- Author(s)
  Ni Y, Zhuge F, Nagashimada M, Ota T.
- Journal Title
  
  Nutrients
  
  Volume: 8 Issue: 7 Pages: 1-16
- DOI
  10.3390/nu8070391
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H03035, KAKENHI-PROJECT-15H05345, KAKENHI-PROJECT-15K12698, KAKENHI-PROJECT-16K18700
[Journal Article] Centra insulin-action activates Kupffer cells by suppressing hepatic vagal activation through nicotinic alpha 7 acetylcholine receptor.2016
- Author(s)
  Kimura K, Tanida M, Nagata N, Inaba Y, Watanabe H, Nagashimada M, Ota T, Asahara S, Kido Y, Matsumoto M, Toshinai K, Nakazato M, Shibamoto T, Kaneko S, Kasuga M, Inoue H
- Journal Title
  
  Cell reports
  
  Volume: 14 Issue: 10 Pages: 2362-2374
- DOI
  10.1016/j.celrep.2016.02.032
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461382, KAKENHI-PROJECT-26560368, KAKENHI-PUBLICLY-15H01373, KAKENHI-PROJECT-15H04851, KAKENHI-PROJECT-15H05345, KAKENHI-PROJECT-15H05678, KAKENHI-PROJECT-25461352, KAKENHI-PROJECT-26670599, KAKENHI-PROJECT-26860693, KAKENHI-PROJECT-26860705, KAKENHI-PROJECT-26870672, KAKENHI-PROJECT-26282022, KAKENHI-PROJECT-16H03035, KAKENHI-PROJECT-15K12698, KAKENHI-PROJECT-16K01815, KAKENHI-PROJECT-16K09767
[Journal Article] DPP-4 inhibition by linagliptin attenuates obesity-related inflammation and insulin resistance by regulating M1/M2 macrophage polarization.2016
- Author(s)
  F Zhuge, Y Ni, M Nagashimada, N Nagata, L Xu, N Mukaida, S Kaneko, T Ota.
- Journal Title
  
  Diabetes
  
  Volume: 65 Issue: 10 Pages: 2966-2679
- DOI
  10.2337/db16-0317
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-16H03035, KAKENHI-PROJECT-15H05345, KAKENHI-PROJECT-15K12698, KAKENHI-PROJECT-16K18700
[Journal Article] Astaxanthin prevents and reverses diet-induced insulin resistance and steatohepatitis in mice: A comparison with vitamin E2015
- Author(s)
  Ni Y, Nagashimada M, Zhuge F, Zhan L, Nagata N, Tsutsui A, Nakanuma Y, Kaneko S, Ota T
- Journal Title
  
  Sci Rep
  
  Volume: 5 Issue: 1 Pages: 17192-17192
- DOI
  10.1038/srep17192
- NAID
  120005682635
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K12698, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-15H05345, KAKENHI-PROJECT-25282017
[Journal Article] Prevention and reversal of lipotoxicity-induced hepatic insulin resistance and steatohepatitis in mice by an antioxidant carotenoid, beta-cryptoxanthin2015
- Author(s)
  Ni Y, Nagashimada M, Zhan. L, Nagata N, Kobori M, Sugiura M, Ogawa K, Kaneko S, Ota T.
- Journal Title
  
  Endocrinology
  
  Volume: 156 Issue: 3 Pages: 987-999
- DOI
  10.1210/en.2014-1776
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25860745, KAKENHI-PROJECT-15K12698, KAKENHI-PROJECT-25282017
[Journal Article] Roles of chemokines and chemokine receptors in obesity-associated insulin resistance and nonalcoholic fatty liver disease.2015
- Author(s)
  Xu L, Kitade H, Ni Y, Ota T
- Journal Title
  
  Biomolecules
  
  Volume: 5 Issue: 3 Pages: 1563-1579
- DOI
  10.3390/biom5031563
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K12698, KAKENHI-PROJECT-25282017
[Journal Article] The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism : a randomised controlled trial2014
- Author(s)
  Y Takeshita, T Takamura, M Honda, Y Kita, Y Zen, KI Kato, H Misu, T Ota, M Nakamura, K Yamada, H Sunagozaka, K Arai, T Yamashita, E Mizukoshi, S Kaneko
- Journal Title
  
  Diabetologia
  
  Volume: 57(5) Issue: 5 Pages: 878-90
- DOI
  10.1007/s00125-013-3149-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23249042, KAKENHI-PROJECT-23701098, KAKENHI-PROJECT-24390187, KAKENHI-PROJECT-25282017, KAKENHI-PROJECT-25461334, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-26461329, KAKENHI-PROJECT-26670378
[Journal Article] β-Cryptoxanthin alleviates diet-induced nonalcoholic steatohepatitis by suppressing inflammatory gene expression in mice2014
- Author(s)
  Kobori M, Ni Y, Takahashi Y, Watanabe N, Sugiura M, Ogawa K, Nagashimada M, Kaneko S, Naito S, Ota, T
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 5 Pages: e98294-e98294
- DOI
  10.1371/journal.pone.0098294
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25282017, KAKENHI-PROJECT-25860745
[Journal Article] LECT2 functions as a hepatokine that links obesity to skeletal muscle insulin resistance2014
- Author(s)
  Fei Lan, H Misu, K Chikamoto, H Takayam, A Kikuchi, K Mohri, N Takata, H Hayashi, N Matsuzawa-Nagata, Y Takeshita, H Noda, Y Matsumoto, T Ota, T Nagano, M Nakagen, K Miyamoto, K Takatsuki, T Seo, K Iwayama, K Tokuyama, S Matsugo, H Tang, Y Saito, S Yamagoe, S Kaneko, T Takamura
- Journal Title
  
  Diabete
  
  Volume: 63 Issue: 5 Pages: 1649-1664
- DOI
  10.2337/db13-0728
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-14J03079, KAKENHI-PROJECT-23590275, KAKENHI-PROJECT-23591301, KAKENHI-PROJECT-25282017, KAKENHI-PROJECT-25292078, KAKENHI-PROJECT-25461334, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-26461329, KAKENHI-PROJECT-26670229
[Journal Article] Selenoprotein P as a diabetes-associated hepatokine that impairs angiogenesis by inducing VEGF resistance in vascular endothelial cells.2014
- Author(s)
  Ishikura K, Misu H, Kumazaki M, Takayama H, Matsuzawa-Nagata N, Tajima N, Chikamoto K, Lan F, Ando H, Ota T, Sakurai M, Takeshita Y, Kato K, Fujimura A, Miyamoto K, Saito Y, Kameo S, Okamoto Y, Takuwa Y, Takahashi K, Kidoya H, Takakura N, Kaneko S, Takamura T
- Journal Title
  
  Diabetologia
  
  Volume: 57 Issue: 9 Pages: 1968-1976
- DOI
  10.1007/s00125-014-3306-9
- NAID
  120005463349
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22112005, KAKENHI-PROJECT-24390051, KAKENHI-PUBLICLY-25116711, KAKENHI-PUBLICLY-25122710, KAKENHI-PROJECT-25282017, KAKENHI-PROJECT-25292078, KAKENHI-PROJECT-25461334, KAKENHI-PROJECT-25670162, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-26461329
[Journal Article] Obesity-induced inflammation and insulin resistance2014
- Author(s)
  Ota T
- Journal Title
  
  Front Endocrinol
  
  Volume: 5 Pages: 204-204
- DOI
  10.3389/fendo.2014.00204
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25282017
[Journal Article] Ectopic fat accumulation and distant organ-specific insulin resistance in Japanese people with nonalcoholic Fatty liver disease2014
- Author(s)
  K Kato, T Takamura, Y Takeshita, Y Ryu, H Misu, T Ota, K Tokuyama, S Nagasaka, M Matsuhisa, O Matsui, S Kaneko
- Journal Title
  
  PLoS One
  
  Volume: 9(3) Issue: 3 Pages: e92170-e92170
- DOI
  10.1371/journal.pone.0092170
- NAID
  120005440398
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23249042, KAKENHI-PROJECT-23591301, KAKENHI-PROJECT-25282017, KAKENHI-PROJECT-25461334, KAKENHI-PROJECT-26461329
[Journal Article] Chemokine systems link obesity to insulin resistance.2013
- Author(s)
  Ota T
- Journal Title
  
  Diabetes Metab J
  
  Volume: 37 Issue: 3 Pages: 165-172
- DOI
  10.4093/dmj.2013.37.3.165
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25282017
[Journal Article] Proteasome dysfunction mediates obesity-induced endoplasmic reticulum stress and insulin resistance in the liver2013
- Author(s)
  T Otoda, T Takamura, H Misu, T Ota, S Murata, H Hayashi, H Takayama, A Kikuchi, T Kanamori, KR Shima, F Lan, T Takeda, S Kurita, K Ishikura, Y Kita, K Iwayama, KI Kato, M Uno, Y Takeshita, M Yamamoto, K Tokuyama, S Iseki, K Tanaka, S Kaneko
- Journal Title
  
  Diabetes
  
  Volume: 62(3) Issue: 3 Pages: 811-24
- DOI
  10.2337/db11-1652
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249042, KAKENHI-PROJECT-23591301, KAKENHI-PROJECT-23791022, KAKENHI-PROJECT-25282017
[Journal Article] Histidine augments the suppression of hepatic glucose production by central insulin action.2013
- Author(s)
  Kimura K, Nakamura Y, Inaba Y, Matsumoto M, Kido Y, Asahara S, Matsuda T, Watanabe H, Maeda A, Inagaki F, Mukai C, Takeda K, Akira S, Ota T, Nakabayashi H, Kaneko S, Kasuga M, Inoue H.
- Journal Title
  
  Diabetes
  
  Volume: 62 Issue: 7 Pages: 2266-77
- DOI
  10.2337/db12-1701
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300274, KAKENHI-PUBLICLY-24116526, KAKENHI-PROJECT-24390003, KAKENHI-PROJECT-24591348, KAKENHI-PROJECT-24650487, KAKENHI-PROJECT-24700826, KAKENHI-PROJECT-24790009, KAKENHI-PUBLICLY-25105717, KAKENHI-PUBLICLY-25126709, KAKENHI-PUBLICLY-25126729, KAKENHI-PROJECT-25282017, KAKENHI-PROJECT-25861179
[Journal Article] CCR5: a novel player in the adipose tissue inflammation and insulin resistance?2013
- Author(s)
  Ota T
- Journal Title
  
  Adipocyte
  
  Volume: 2 Issue: 2 Pages: 99-103
- DOI
  10.4161/adip.22420
- NAID
  40020812627
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25282017
[Journal Article] CCR5 plays a critical role in obesity-induced adipose tissue inflammation and insulin resistance by regulating both macrophage recruitment and M1/M2 status2012
- Author(s)
  Kitade H, Sawamoto K, Nagashimada M, Inoue H, Yamamoto Y, Sai Y, Takamura T, Yamamoto H, Miyamoto K, Ginsberg HN, Mukaida N, Kaneko S, Ota T
- Journal Title
  
  Diabetes IN PRESS
  
  Volume: 61(7) Issue: 7 Pages: 1680-90
- DOI
  10.2337/db11-1506
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790854, KAKENHI-PROJECT-23249042, KAKENHI-PROJECT-23591301, KAKENHI-PROJECT-23659430
[Journal Article] Endoplasmic reticulum stress inhibits STAT3-dependent suppression of hepatic gluconeogenesis via dephosphorylation and deacetylation2012
- Author(s)
  Kimura K, Yamada T, Matsumoto M, Kido Y, Hosooka T, Asahara S, Matsuda T, Ota T, Watanabe H, Sai Y, Miyamoto K, Kaneko S, Kasuga M, Inoue H
- Journal Title
  
  Diabetes
  
  Volume: 61 Pages: 61-73
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790854
[Journal Article] Inverse Correlation between Serum Levels of Selenoprotein P and Adiponectin in Patients with Type 2 Diabetes2012
- Author(s)
  Misu H, Ishikura K, Kurita S, Takeshita Y, Ota T, Saito Y, Takahashi K, Kaneko S, Takamura T
- Journal Title
  
  PLoS One
  
  Volume: 7
- NAID
  120004140847
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790854
[Journal Article] 脂肪肝の成因としての小胞体ストレスの意義,小胞体ストレスと疾患2011
- Author(s)
  太田嗣人
- Journal Title
  
  Bio Clinica
  
  Volume: 26(7) Pages: 28-32
- Data Source
  KAKENHI-PROJECT-22790854
[Journal Article] Different fatty acids inhibit apolipoprotein B100 secretion by different pathways : Unique roles for endoplasmic reticulum stress, ceramide, and autophagy2011
- Author(s)
  Caviglia JM, Gayet C, Ota T, Hernandez-Ono A, Conlon DM, Jiang H, Fisher EA, Ginsberg HN
- Journal Title
  
  J Lipid Res
  
  Volume: 52 Pages: 1636-1651
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790854
[Journal Article] 慢性炎症とインスリン抵抗性をリンクするケモカインの役割,メタボリックシンドロームII(後篇)-メタボリックシンドロームの基礎-成因と病態/遺伝子・病態・標的分子の面から2011
- Author(s)
  太田嗣人, 篁俊成
- Journal Title
  
  ケモカイン最新医学
  
  Volume: 66(6) Pages: 192-204
- Data Source
  KAKENHI-PROJECT-22790854
[Journal Article] A liver-derived secretory protein, selenoprotein P, causes insulin resistance2010
- Author(s)
  Misu H, Takamura T, Takayama H, Hayashi H, Matsuzawa-Nagata N, Kurita S, Ishikura K, Ando H, Takeshita Y, Ota T, Sakurai M, Yamashita T, Mizukoshi E, Honda M, Miyamoto K, Kubota T, Kubota N, Kadowaki T, Kim HJ, Lee IK, Minokoshi Y, Saito Y, Takahashi K, Yamada Y, Takakura N, Kaneko S
- Journal Title
  
  Cell Metab
  
  Volume: 12 Pages: 483-495
- NAID
  120002661942
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790854
[Journal Article] Effect of pioglitazone on muscle sympathetic nerve activity in type 2 diabetes mellitus with alpha-glucosidase inhibitor2010
- Author(s)
  Kobayashi D, Takamura M, Murai H, Usui S, Ikeda T, Inomata J, Takashima S, Kato T, Furusho H, Takeshita Y, Ota T, Takamura T, Kaneko S
- Journal Title
  
  Auton Neurosci
  
  Volume: 158 Pages: 86-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790854
[Journal Article] 肝疾患における血液,脂質一般検査生化学検査の臨床的意義2010
- Author(s)
  太田嗣人, 篁俊成
- Journal Title
  
  肝胆膵
  
  Volume: 60 Pages: 541-547
- Data Source
  KAKENHI-PROJECT-22790854
[Journal Article] Palmitate Induces Insulin Resistance in H4IIEC3 Hepatocytes through Reactive Oxygen Species Produced by Mitochondria.2009
- Author(s)
  Nakamura S, Takamura T, Matsuzawa-Nagata N, Takayama H, Misu H, Noda H, Nabemoto S, Kurita S, Ota T, et al.
- Journal Title
  
  J Biol Chem 284
  
  Pages: 14809-14818
- NAID
  120002829203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790643
[Journal Article] 高脂血症・脂肪肝形成におけるERストレスの意義メタボリックシンドロームから消化器疾患に迫る2009
- Author(s)
  太田嗣人
- Journal Title
  
  分子消化器病 6
  
  Pages: 37-40
- Data Source
  KAKENHI-PROJECT-20790643
[Journal Article] Palmitate Induces Insulin Resistance in H4IIEC3 Hepatocytes through Reactive Oxygen Species Produced by Mitochondria.2009
- Author(s)
  Nakamura S, Takamura T, Matsuzawa-Nagata N, Takayama H, Misu H, Noda H, Nabemoto S, Kurita S, Ota T, Ando H, Miyamoto K, Kaneko S
- Journal Title
  
  J Biol Chem 284
  
  Pages: 14809-14818
- NAID
  120002829203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790643
[Journal Article] Increased oxidative stress precedes the onset of high-fat diet-induced insulin resistance and obesity.2008
- Author(s)
  Matsuzawa-Nagata N, Takamura T, Ando H, Nakamura S, Kurita S, Misu H, Ota T, Yokoyama M, Honda M, Miyamoto K, Kaneko S
- Journal Title
  
  Metabolism 57
  
  Pages: 1071-1077
- NAID
  120001130340
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790643
[Journal Article] Tranilast, an antifibrogenic agent, ameliorates a dietary rat model of nonalcoholic steatohepatitis2008
- Author(s)
  Uno M, Kurita S, Misu H, Ando H, Ota T, et.al.
- Journal Title
  
  Hepatology 48
  
  Pages: 109-118
- NAID
  120001130339
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790643
[Journal Article] 脂肪肝とリポトキシシティ;リポトキシシティを見直す2008
- Author(s)
  太田嗣人, 篁俊成
- Journal Title
  
  The Lipid 19
  
  Pages: 20-26
- Data Source
  KAKENHI-PROJECT-20790643
[Journal Article] Olmesartan ameliorates a dietary rat model of non-alcoholic steatohepatitis through itspleiotropic effects2008
- Author(s)
  Kurita S, Takamura T, Ota T, et.al.
- Journal Title
  
  Eur J Pharmacol 588
  
  Pages: 316-324
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790643
[Journal Article] Obesity upregulates genes involved in oxidative phosphorylation in livers of diabetic patients.2008
- Author(s)
  Takamura T, Misu H, Matsuzawa-Nagata N, Sakurai M, Ota T, Shimizu A, Kurita S, Takeshita Y, Ando H, Honda M, Kaneko S
- Journal Title
  
  Obesity (Silver Spring) 16
  
  Pages: 2601-2609
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790643
[Journal Article] Tranilast, an antifibrogenic agent, ameliorates a dietary rat model of nonalcoholic steatohepatitis.2008
- Author(s)
  Uno M, Kurita S, Misu H, Ando H, Ota T, Matsuzawa-Nagata N, Kita Y, Nabemoto S, Akahori H, Zen Y, Nakanuma Y, Kaneko S, Takamura T
- Journal Title
  
  Hepatology 48
  
  Pages: 109-118
- NAID
  120001130339
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790643
[Journal Article] Increased oxidative stress precedes the onset of high-fat diet-induced insulin resistanceand obesity2008
- Author(s)
  Takamura T, Misu H, Matsuzawa N, Sakurai M, Ota T, et.al.
- Journal Title
  
  Metabolism 57
  
  Pages: 1071-1077
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790643
[Journal Article] Olmesartan ameliorates a dietary rat model of non-alcoholic steatohepatitis through its pleiotropic effects.2008
- Author(s)
  Kurita S, Takamura T, Ota T, Matsuzawa-Nagata N, Kita Y, Uno M, Nabemoto S, Ishikura K, Misu H, Ando H, Zen Y, Nakanuma Y, Kaneko S
- Journal Title
  
  Eur J Pharmacol 588
  
  Pages: 316-324
- NAID
  120001130222
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790643
[Presentation] 食品因子からのNASH／NAFLD の創薬シードの探求2019
- Author(s)
  太田嗣人
- Organizer
  第6回肝臓と糖尿病・代謝研究会
- Invited
- Data Source
  KAKENHI-PROJECT-19H04047
[Presentation] 糖尿病に併発するNASH/NAFLDへのアプローチ2019
- Author(s)
  太田嗣人
- Organizer
  第53回糖尿病学の進歩
- Invited
- Data Source
  KAKENHI-PROJECT-16H03035
[Presentation] 糖尿病とNAFLD/NASH2019
- Author(s)
  太田嗣人
- Organizer
  第62回日本糖尿病学会年次学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19H04047
[Presentation] 第61回日本糖尿病学会年次学術集会2018
- Author(s)
  太田嗣人
- Organizer
  VLDL分泌制御の多様なメカニズム
- Invited
- Data Source
  KAKENHI-PROJECT-16H03035
[Presentation] 免疫・ストレス応答制御に基づく肥満症・脂肪肝の病態解明と創薬展開2018
- Author(s)
  太田嗣人
- Organizer
  第39回日本肥満学会
- Invited
- Data Source
  KAKENHI-PROJECT-16H03035
[Presentation] 食品因子による内臓脂肪・異所性脂肪へのアプローチ2018
- Author(s)
  太田嗣人
- Organizer
  第72回日本栄養・食糧学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-16H03035
[Presentation] 食品因子による脂肪肝と糖尿病へのアプローチ2018
- Author(s)
  太田嗣人
- Organizer
  第34回日本静脈経腸栄養学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-16H03035
[Presentation] Emerging Roles of SGLT2 Inhibitor in Obesity: Fat Browning and Macrophage Polarization2018
- Author(s)
  Tsuguhito Ota
- Organizer
  ICOMES2018 International Congress on Obesity and MEtabolic Syndrome
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H03035
[Presentation] 糖尿病と肝疾患2018
- Author(s)
  太田嗣人
- Organizer
  第61回日本糖尿病学会年次学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-16H03035
[Presentation] NAFLD/NASHにおける新知見と治療の方向性2018
- Author(s)
  太田嗣人
- Organizer
  第52回糖尿病学の進歩
- Invited
- Data Source
  KAKENHI-PROJECT-16H03035
[Presentation] 食品因子からNAFLD/NASH、肥満症の創薬シードを探求する2018
- Author(s)
  太田嗣人
- Organizer
  第28回臨床内分泌代謝Update
- Invited
- Data Source
  KAKENHI-PROJECT-16H03035
[Presentation] スルフォラファンによる転写因子 Nrf2 活性化を介したエネルギー代謝調節機構の検討2017
- Author(s)
  太田嗣人牛田悠介,菅沼大行,長田直人
- Organizer
  第71回日本栄養・食糧学会大会,沖縄コンベンションセンター
- Data Source
  KAKENHI-PROJECT-16H03035
[Presentation] Nrf2 Activation by Glucoraphanin Relieves Obesity and Insulin Resistance through Increased Energy Expenditure and Alternative Activation of Macrophages2016
- Author(s)
  NAOTO NAGATA, YUSUKE USHIDA, YUDAI AOKI, LIANG XU, FEN ZHUGE, HIROYUKI SUGANUMA, SHUICHI KANEKO, TSUGUHITO OTA
- Organizer
  第76回アメリカ糖尿病学会
- Place of Presentation
  ニューオリンズ、アメリカ
- Year and Date
  2016-06-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K12698
[Presentation] Nrf2 Activation by Glucoraphanin Relieves Obesity and Insulin Resistance through Increased Energy Expenditure and Alternative Activation of Macrophages2016
- Author(s)
  NAOTO NAGATA, YUSUKE USHIDA, YUDAI AOKI, LIANG XU, FEN ZHUGE, HIROYUKI SUGANUMA, SHUICHI KANEKO, TSUGUHITO OTA
- Organizer
  第76回アメリカ糖尿病学会
- Place of Presentation
  ニューオリンズ、アメリカ
- Year and Date
  2016-06-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H03035
[Presentation] スルフォラファンによる転写因子Nrf2活性化を介した肥満及び代謝異常抑制機構の解析2016
- Author(s)
  長田直人 ,牛田悠介 ,菅沼大行 ,Xu Liang ,Zhuge Fen ,太田嗣人
- Organizer
  第59回日本糖尿病学会年次学術集会
- Place of Presentation
  国立京都国際会館、京都府
- Year and Date
  2016-05-20
- Data Source
  KAKENHI-PROJECT-15K12698
[Presentation] スルフォラファンによる転写因子Nrf2活性化を介した肥満及び代謝異常抑制機構の解析2016
- Author(s)
  長田直人 ,牛田悠介 ,菅沼大行 ,Xu Liang ,Zhuge Fen ,太田嗣人
- Organizer
  第59回日本糖尿病学会年次学術集会
- Place of Presentation
  国立京都国際会館、京都府
- Year and Date
  2016-05-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H03035
[Presentation] Glucoraphanin-mediated Nrf2 activation reduces obesity and insulin resistance by increasing energy expenditure and limiting endotoxaemia-related chronic inflammation2016
- Author(s)
  Ota T, Ushida Y, Aoki Y, Xu L, Zhuge F, Suganuma H, Kaneko S, Nagata N
- Organizer
  EASD2016
- Place of Presentation
  ミュンヘン、ドイツ
- Year and Date
  2016-09-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H03035
[Presentation] Nrf2 activation by glucoraphanin alleviates obesity and insulin resistance through increased energy expenditure and alternative activation of macrophages2016
- Author(s)
  T Ota, N Nagata, Y Ushida, Y Aoki, L Xu, F Zhuge, H Suganuma, S Kaneko
- Organizer
  Keystone Symposia Conference G1: New Therapeutics for Diabetes and Obesity
- Place of Presentation
  ラホーヤ、米国
- Year and Date
  2016-04-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H03035
[Presentation] スルフォラファンによる転写因子Nrf2活性化を介した肥満及びNAFLD抑制機構の検討2016
- Author(s)
  長田直人,牛田悠介, 菅沼大行, Xu Liang, Zhuge Fen, 金子周一, 太田嗣人
- Organizer
  第28回分子糖尿病学シンポジウム
- Place of Presentation
  富山市、富山県
- Year and Date
  2016-12-03
- Data Source
  KAKENHI-PROJECT-15K12698
[Presentation] Glucoraphanin-mediated Nrf2 activation reduces obesity and insulin resistance by increasing energy expenditure and limiting endotoxaemia-related chronic inflammation2016
- Author(s)
  Ota T, Ushida Y, Aoki Y, Xu L, Zhuge F, Suganuma H, Kaneko S, Nagata N
- Organizer
  EASD2016
- Place of Presentation
  ミュンヘン、ドイツ
- Year and Date
  2016-09-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K12698
[Presentation] Nrf2 activation by glucoraphanin alleviates obesity and insulin resistance through increased energy expenditure and alternative activation of macrophages2016
- Author(s)
  T Ota, N Nagata, Y Ushida, Y Aoki, L Xu, F Zhuge, H Suganuma, S Kaneko
- Organizer
  Keystone Symposia Conference G1: New Therapeutics for Diabetes and Obesity
- Place of Presentation
  ラホーヤ、米国
- Year and Date
  2016-04-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K12698
[Presentation] スルフォラファンによる転写因子Nrf2活性化を介した肥満及びNAFLD抑制機構の検討2016
- Author(s)
  長田直人,牛田悠介, 菅沼大行, Xu Liang, Zhuge Fen, 金子周一, 太田嗣人
- Organizer
  第28回分子糖尿病学シンポジウム
- Place of Presentation
  富山市、富山県
- Year and Date
  2016-12-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H03035
[Presentation] 肝臓リポトキシシティへのアスタキサンチンの作用2014
- Author(s)
  太田嗣人
- Organizer
  第10回アスタキサンチンシンポジウム
- Place of Presentation
  北海道大学医学部学友会館フラテ、札幌、北海道
- Year and Date
  2014-09-12
- Invited
- Data Source
  KAKENHI-PROJECT-25282017
[Presentation] Common DiseaseとしてのNAFLD/NASHの臨床2014
- Author(s)
  太田嗣人
- Organizer
  日本内科学会第64回北陸支部生涯教育講演会
- Place of Presentation
  アイザック小杉文化ホールラポール、射水市、富山
- Year and Date
  2014-09-07
- Invited
- Data Source
  KAKENHI-PROJECT-25282017
[Presentation] カロテノイドによる自然免疫への作用と脂肪肝炎の進展抑止2014
- Author(s)
  太田嗣人
- Organizer
  平成26年度カロテノイド若手の会
- Place of Presentation
  石川県立大学、白山市、石川県
- Year and Date
  2014-09-03
- Invited
- Data Source
  KAKENHI-PROJECT-25282017
[Presentation] Astaxathin and lipotoxicity-induced NASH、The 13th Japan-Korea Diabetic Nephropathy Seminar2014
- Author(s)
  Tsuguhito Ota
- Organizer
  The 13th Japan-Korea Diabetic Nephropathy Seminar
- Place of Presentation
  ニューグランドホテル、金沢、石川県
- Year and Date
  2014-09-26
- Invited
- Data Source
  KAKENHI-PROJECT-25282017
[Presentation] Astaxathin and lipotoxicity-induced NASH2014
- Author(s)
  太田嗣人
- Organizer
  第17回国際フリーラジカル会議　SFRRI2014
- Place of Presentation
  京都国際会議場、京都
- Invited
- Data Source
  KAKENHI-PROJECT-25282017
[Presentation] Preventive Effect of Astaxanthin on Lipotoxic Model of NASH2013
- Author(s)
  太田嗣人
- Organizer
  8th Asia Pacific Conference on Clinical Nutrition APCCN 2013
- Place of Presentation
  The Tokyo Bay Maihama Hotel Club、千葉
- Invited
- Data Source
  KAKENHI-PROJECT-25282017
[Presentation] Inhibitory effect of astaxanthin on the progression of lipotoxic model of nonalcoholic steatohepatitis2013
- Author(s)
  太田嗣人
- Organizer
  第45回日本動脈硬化学会
- Place of Presentation
  京王プラザホテル、東京
- Invited
- Data Source
  KAKENHI-PROJECT-25282017
[Presentation] CCR5 ablation prevents insulin resistance induced by high-fat feeding or leptin deficiency2012
- Author(s)
  Tsuguhito Ota, Hironori Kitade, Kazuki Sawamoto, Hiroshi Inoue, Toshinari Takamura, Naofumi Mukaida, Shuichi Kaneko
- Organizer
  第16回国際動脈硬化シンポジウム
- Place of Presentation
  シドニー(オーストラリア)
- Year and Date
  2012-03-28
- Data Source
  KAKENHI-PROJECT-22790854
[Presentation] 肥満による炎症とインスリン抵抗性をリンクするCCR5の役割～脂肪組織マクロファージの量および質の調節への関与～2012
- Author(s)
  太田嗣人1、澤本一樹1、北出紘規1、山本靖彦2、井上啓1、篁俊成3、山本博2、向田直史4、金子周一3
- Organizer
  第26回日本糖尿病・肥満動物学会年次学術集会
- Place of Presentation
  愛知県産業労働センター(愛知)
- Year and Date
  2012-02-17
- Data Source
  KAKENHI-PROJECT-22790854
[Presentation] CCR5欠損はob/obマウスの脂肪組織の炎症を軽減し糖代謝異常を改善する2011
- Author(s)
  太田嗣人,北出紘規,澤本一樹,井上啓,篁俊成,宮本謙一,向田直史,金子周一
- Organizer
  第54回日本糖尿病学会年次学術集会
- Place of Presentation
  ロイトン札幌(北海道)
- Year and Date
  2011-05-21
- Data Source
  KAKENHI-PROJECT-22790854
[Presentation] CCR5 plays a critical role in the inflammatory adipose tissue response to high-fat feeding and obesity by regulating both macrophage recruitment and M1/M2 status2011
- Author(s)
  TSUGUHITO OTA, KAZUKI SAWAMOTO, HIRONORI KITADE, YASUHIKO YAMAMOTO. HIROSHI INOUE, TOSHINARI TAKAMURA, KEN-ICHI MIYAMOTO, HIROSHI YAMAMOTO, NAOFUMI MUKAIDA, SHUICHI KANEKO
- Organizer
  第71回アメリカ糖尿病学会
- Place of Presentation
  サンディエゴ(米国)
- Year and Date
  2011-06-24
- Data Source
  KAKENHI-PROJECT-22790854
[Presentation] CCR5 plays a critical role in the inflammatory adipose tissue response to obesity by regulating both macrophage recruitment and M1/M2 status2011
- Author(s)
  Tsuguhito Ota, Kazuki Sawamoto, Hironori Kitade, Yasuhiko Yamamoto, Hiroshi Inoue, Toshinari Takamura, Ken-ichi Miyamoto, Hiroshi Yamamoto Naofumi Mukaida, Shuichi Kaneko
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-22790854
[Presentation] 肥満によるる脂肪組織マクロファージの量の変化と質の調節が関わるインスリン抵抗性の発症にはCCR5によ2011
- Author(s)
  澤本一樹,北出紘規, Ni Yinhua,山本靖彦,井上啓,篁俊成,宮本謙一,山本博,向田直史,金子周一,太田嗣人
- Organizer
  第54回日本糖尿病学会年次学術集会
- Place of Presentation
  ロイトン札幌(北海道)
- Year and Date
  2011-05-21
- Data Source
  KAKENHI-PROJECT-22790854
[Presentation] 肥満による炎症とインスリン抵抗性をリンクするCCR5の意義～脂肪組織マクロファージの量および質の調整への関与～2011
- Author(s)
  太田嗣人,澤本一樹,北出紘規,山本靖彦,井上啓,篁俊成,山本博,向田直史,金子周一
- Organizer
  第26回日本糖尿病合併症学会
- Place of Presentation
  大宮ソニックシティ(埼玉県)
- Year and Date
  2011-10-14
- Data Source
  KAKENHI-PROJECT-22790854
[Presentation] CCR5 deficiency attenuates obesity-induced insulin resistance through M2 dominant shift in adipose tissue macrophage2011
- Author(s)
  太田嗣人
- Organizer
  第47回欧州糖尿病学会議(EASD)
- Place of Presentation
  リスボン、ポルトガル
- Year and Date
  2011-09-15
- Data Source
  KAKENHI-PROJECT-22790854
[Presentation] CCR5の欠損はob/obマウスの脂肪組織の炎症を軽減しインスリン抵抗性を改善する2011
- Author(s)
  太田嗣人,北出紘規,澤本一樹,井上啓,金子周一
- Organizer
  第32回日本肥満学会
- Place of Presentation
  淡路夢舞台国際会議場(兵庫県)
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-22790854
[Presentation] CCR5 plays a critical role in the inflammatory adipose tissue response to high-fat feeding and obesity by regulating both macrophage recruitment and M1/M2 status2011
- Author(s)
  太田嗣人
- Organizer
  第71回米国糖尿病学会(ADA)
- Place of Presentation
  サンディエゴ、米国
- Year and Date
  2011-06-24
- Data Source
  KAKENHI-PROJECT-22790854
[Presentation] Loss of CCR5 attenuates obesity-induced insulin resistance through M2 dominant shift in adipose tissue macrophage2011
- Author(s)
  Tsuguhito Ota, Kazuki Sawamoto, Hironori Kitade, Yasuhiko Yamamoto, Hiroshi Inoue, Toshinari Takamura, Ken-ichi Miyamoto, Hiroshi Yamamoto Naofumi Mukaida, Shuichi Kaneko
- Organizer
  第21回2011年国際糖尿病学会議(IDF2011)
- Place of Presentation
  ドバイ(アラブ首長国連邦)
- Year and Date
  2011-12-08
- Data Source
  KAKENHI-PROJECT-22790854
[Presentation] CCR5 deficiency attenuates obesity-induced insulin resistance through M2 dominant shift in adipose tissue macrophage2011
- Author(s)
  T. Ota, K. Sawamoto, H. Kitade, Y. Yamamot o, H. Inoue, T. Takamura, H. Yamamoto, N. M ukaida, S. Kaneko
- Organizer
  第47回欧州糖尿病学会議総会
- Place of Presentation
  日リスボン(ポルトガル)
- Year and Date
  2011-09-15
- Data Source
  KAKENHI-PROJECT-22790854
[Presentation] ケモカイン受容体CCR5の欠損は脂肪組織の炎症と全身のインスリン抵抗性を改善する2011
- Author(s)
  太田嗣人,北出紘規,澤本一樹,井上啓,篁俊成,宮本謙一,向田直史,金子周一
- Organizer
  第84回日本内分泌学会学術総会
- Place of Presentation
  神戸国際会議場(兵庫)
- Year and Date
  2011-04-23
- Data Source
  KAKENHI-PROJECT-22790854
[Presentation] CCR5 ablation prevents insulin resistance by high-fat feeding or leptin deficiency2011
- Author(s)
  T Ota, H Kitade, K Sawamoto, H Inoue, T Takamura, K Miyamoto, N Mukaida, S Kaneko
- Organizer
  日本分子生物学会第11回春季シンポジウム
- Place of Presentation
  石川県立音楽堂(石川)
- Year and Date
  2011-05-26
- Data Source
  KAKENHI-PROJECT-22790854
[Presentation] CCR5 PROMOTES ADIPOSE TISSUE INFLAMMATION AND WHOLE-BODY INSULIN RESISTANCE2010
- Author(s)
  T Ota, H Kitade, K Sawamoto, H Inoue, T Takamura, K Miyamoto, N Mukaida, S Kaneko
- Organizer
  第8回国際糖尿病連合西太平洋地区会議
- Place of Presentation
  釜山(韓国)
- Year and Date
  2010-10-19
- Data Source
  KAKENHI-PROJECT-22790854
[Presentation] CCR5 promotes adipose tissue inflammation and Insulin resistance in obesity2010
- Author(s)
  Tsuguhito Ota, Hironori Kitade, Kazuki Sawamoto, Hiroshi Inoue, Shuichi Kaneko
- Organizer
  第46回欧州糖尿病学会議
- Place of Presentation
  ストックホルム(スウェーデン)
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-22790854
[Presentation] KANEKO, CCR5 Ablation Prevents Insulin Resistance Induced by High-Fat Feeding or Leptin Deficiency2010
- Author(s)
  TSUGUHITO OTA, HIRONORI KITADE, KAZUKI SAWAMOTO, HIROSHI INOUE, TOSHINARI TAKAMURA, KEN-ICHI MIYAMOTO, NAOFUMI MUKAIDA, SHUICHI KANEKO
- Organizer
  第70回アメリカ糖尿病学会
- Place of Presentation
  オーランド(米国)
- Year and Date
  2010-06-27
- Data Source
  KAKENHI-PROJECT-22790854
[Presentation] CCR5 Ablation Prevents Insulin Resistance Induced by High-Fat Feeding or Leptin Deficiency2010
- Author(s)
  KAZUKI SAWAMOTO, TSUGUHITO OTA, HIRONORI KITADE, HIROSHI INOUE, TOSHINARI TAKAMURA, KEN-ICHI MIYAMOTO, NAOFUMI MUKAIDA, SHUICHI KANEKO
- Organizer
  第33回日本分子生物学会年会、第83回日本生化学会大会合同大会
- Place of Presentation
  神戸国際会議場(兵庫)
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-22790854
[Presentation] CCR5 ablation prevents insulin resistance induced by high-fat feeding or leptin deficiency2010
- Author(s)
  太田嗣人
- Organizer
  米国糖尿病学会(ADA)
- Place of Presentation
  Orange County Convention Center(米国)
- Year and Date
  2010-06-27
- Data Source
  KAKENHI-PROJECT-22790854
[Presentation] 肥満による炎症とインスリン抵抗性の形成によるケモカイン受容体CCR5の重要性2010
- Author(s)
  太田嗣人,北出紘規,澤本一樹,井上啓,向田直史,金子周一
- Organizer
  第31回日本肥満学会
- Place of Presentation
  前橋テルサ(群馬)
- Year and Date
  2010-10-01
- Data Source
  KAKENHI-PROJECT-22790854
[Presentation] インスリン抵抗性形成におけるケモカインレセプターCCR5の役割2010
- Author(s)
  北出紘規,太田嗣人,澤本一樹,井上啓,篁俊成,宮本謙一,向田直史,金子周一
- Organizer
  第25回日本糖尿病合併症学会
- Place of Presentation
  びわ湖ホール(滋賀)
- Year and Date
  2010-10-22
- Data Source
  KAKENHI-PROJECT-22790854
[Presentation] インスリン抵抗性の形成におけるケモカイン受容体CCR5の役割2010
- Author(s)
  太田嗣人,北出紘規,澤本一樹,井上啓,篁俊成,宮本謙一,向田直史,金子周一
- Organizer
  第22回日本分子糖尿病シンポジウム
- Place of Presentation
  東京コンファレンスセンター品川(東京)
- Year and Date
  2010-12-04
- Data Source
  KAKENHI-PROJECT-22790854
[Presentation] インスリン抵抗性の形成におけるケモカインレセプターCCR5の役割2010
- Author(s)
  太田嗣人,北出紘規,澤本一樹,井上啓,篁俊成,宮本謙一,向田直史,金子周一
- Organizer
  第53回日本糖尿病学会年次学術集会
- Place of Presentation
  岡山全日空ホテル(岡山)
- Year and Date
  2010-05-29
- Data Source
  KAKENHI-PROJECT-22790854
[Presentation] Inhibition Of Apolipoprotein B100 Secretion By Lipid-induced Hepatic Endoplasmic Stress2009
- Author(s)
  Ota T, Gayet C, Ginsberg HN
- Organizer
  第41回動脈硬化学会
- Place of Presentation
  海峡メッセ(山口)
- Year and Date
  2009-07-17
- Data Source
  KAKENHI-PROJECT-20790643
[Presentation] Identification of a redox-associated hepatokine that contributes to systemic insulin resistance Keystone Symposia on Molecular and Cellular Biology2009
- Author(s)
  Takamura T, Misu H, Nagata N, Ishikura K, Ota T, Kaneko S
- Organizer
  Type 2 Diabetes and Insulin Resistance J3 352
- Place of Presentation
  USA
- Year and Date
  2009-01-21
- Data Source
  KAKENHI-PROJECT-20790643
[Presentation] インスリン抵抗性で生じる小胞体ストレスはapoB分泌を選択的に阻害し脂肪肝を促進する2008
- Author(s)
  太田嗣人, 篁俊成, 金子周一, Henry Ginsberg
- Organizer
  第23回日本糖尿病合併症学会
- Place of Presentation
  日本都市センター(東京)
- Year and Date
  2008-10-03
- Data Source
  KAKENHI-PROJECT-20790643
[Presentation] Different fatty acids inhibit apoB100 secretion by both common and unique molecular pathways Diabetologia 51 (suppl. 1) S2992008
- Author(s)
  Ota T, Gayet C, Ginsberg HN
- Organizer
  Presented at the 2008 Meeting of the European Association for the Study of Diabetes (EASD)
- Place of Presentation
  Italy
- Year and Date
  2008-09-09
- Data Source
  KAKENHI-PROJECT-20790643
[Presentation] Ginsberg HN脂肪酸誘導性肝小胞体ストレスはapoB100分泌を選択的に阻害し肝脂肪化を促進する2008
- Author(s)
  太田嗣人
- Organizer
  第51日本糖尿病学会年次学術集会
- Place of Presentation
  東京フォーラム(東京)
- Year and Date
  2008-05-23
- Data Source
  KAKENHI-PROJECT-20790643
[Presentation] Different fatty acids inhibit apoB100 secretion by both common and unique molecularpathways2008
- Author(s)
  Ota T. Gavet C. Ginsbera HN
- Organizer
  2008年欧州糖尿病学会議(EASD)
- Place of Presentation
  ローマ
- Year and Date
  2008-09-10
- Data Source
  KAKENHI-PROJECT-20790643
[Presentation] NASH: Emerging Roles of Lipotoxicity and Astaxanthin
- Author(s)
  Tsuguhito Ota
- Organizer
  第104回中華民国（台湾）消化器系総合学術年会総会
- Place of Presentation
  国立台大病院国際会議センター、台北、台湾
- Year and Date
  2015-03-28 – 2015-03-29
- Invited
- Data Source
  KAKENHI-PROJECT-25282017
[Presentation] The Chemokine System in Obesity-induced Insulin Resistance: a Possible Theraperutic Target?
- Author(s)
  Tsuguhito Ota
- Organizer
  The 47th Spring Conference of the Korean Society of Lipidology & Atherosclerosis
- Place of Presentation
  Kimdaejung Convention Center、光州、韓国
- Year and Date
  2014-04-18 – 2014-04-19
- Invited
- Data Source
  KAKENHI-PROJECT-25282017
[Presentation] カロテノイドによる脂肪肝炎の進展抑止
- Author(s)
  太田嗣人
- Organizer
  日本薬学会関東支部第38回学術講演会
- Place of Presentation
  日本薬学会長井記念館長井記念ホール、東京
- Invited
- Data Source
  KAKENHI-PROJECT-25282017

1. KANEKO Shuichi (60185923)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
2. IKARASHI NOBUTOMO (40409363)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. 本多政夫 (00272980)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 井上啓 (50397832)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 篁俊成 (00324111)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. 水腰英四郎 (90345611)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 御簾博文 (80447680)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 竹下有美枝 (40507042)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 今理紗子 (90779943)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. 岩崎雄介 (10409360)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 玉木陽穂 (60455714)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Nagata Naoto

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
13. MASAKI Takahiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 高橋智聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 永島田まゆみ

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
16. 高倉伸幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 酒井佳夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 滝山由美

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
19. 淺原俊一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ota Tsuguhito 太田 嗣人

OTA Tsuguhito 太田 嗣人

Research Projects

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Co-Researchers

New regulatory mechanisms of skin functional molecules via gut microbiota

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血中リポ多糖(LPS)管理の非アルコール性脂肪性肝疾患への有用性の検討

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エネルギー代謝を亢進させる抗肥満機能性食品創出のための基盤研究Principal Investigator

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Research and development for energy expending anti-obesity functional foodPrincipal Investigator

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Elucidating mechanisms specific to NASH-associated HCC developmentPrincipal Investigator

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Study of the liver as an endocrine organ

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Development of novel pharmacological treatments for nonalcoholic steatohepatitis: an application of carotenoid compoundPrincipal Investigator

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Role of CCR5 and CX3CR1 in the development of insulin resistancePrincipal Investigator

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Regulation of hepatic glucose and lipid metabolism by ER stress responsePrincipal Investigator

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[Book] 肥満症・インスリン抵抗性がもたらす肝の炎症シグナル 非アルコール性脂肪性肝疾患（NAFLD/NASH）の最新知見2020

Author(s)

Total Pages

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Data Source

[Book] NASH/NAFLD Ⅱ章 動脈硬化を識る B.危険因子・関連疾患とその予防・治療動脈硬化診療のすべて 日本医師会雑誌148巻 特別号(２)2019

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[Book] NASH/NAFLDの新知見，インスリン抵抗性改善化合物 肝胆膵2018

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[Book] 糖尿病薬と肝疾患治療, 糖尿病の最新治療2018

Author(s)

Total Pages

Publisher

Ota Tsuguhito 太田嗣人

OTA Tsuguhito 太田嗣人

[Book] 肥満症・インスリン抵抗性がもたらす肝の炎症シグナル　非アルコール性脂肪性肝疾患（NAFLD/NASH）の最新知見2020

[Book] NASH/NAFLD Ⅱ章動脈硬化を識る B.危険因子・関連疾患とその予防・治療動脈硬化診療のすべて　日本医師会雑誌148巻特別号(２)2019

[Book] NASH/NAFLDの新知見，インスリン抵抗性改善化合物　肝胆膵2018

[Book] スルフォラファンの肥満抑制効果　BIO INDUSTRY2018

[Book] インスリン抵抗性改善薬　Ⅳ.NAFLD/NASHの治療学NAFLD/NASH～診断・治療の最新動向2018

[Book] 高TG血症に関連する疾患の管理と治療　NASH/NAFLD 最新医学別冊診断と治療のABC1382018

[Book] CCR5による脂肪組織マクロファージの動態制御―CCR5とインスリン抵抗性　医学のあゆみ2016

[Book] 肝臓を大切に－血糖値が気になる人のためのお話－　月刊糖尿病ライフさかえ2016

[Book] ビグアナイド薬の効果的な使い方、経口糖尿病治療薬2016－病態に応じたベストチョイス　糖尿病診療マスター2016

[Book] ビグアナイド薬の効果的な使い方、経口糖尿病治療薬2016－病態に応じたベストチョイス　糖尿病診療マスター2016

[Book] CCR5による脂肪組織マクロファージの動態制御―CCR5とインスリン抵抗性　医学のあゆみ2016

[Book] 肝臓を大切に－血糖値が気になる人のためのお話－　月刊糖尿病ライフさかえ2016