Hyodo Ichinosuke 兵頭一之介

… Alternative Names

HYODO ICHINOSUKE 兵頭一之介

HYODO Ichinosuke 兵頭一之介

兵頭一之介ヒョウドウイチノスケ

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Researcher Number	60416469
Affiliation (Current)	2025: 独立行政法人国立病院機構四国がんセンター(臨床研究センター), その他部局等, 医師
Affiliation (based on the past Project Information) *help	2020: 独立行政法人国立病院機構四国がんセンター(臨床研究センター), その他部局等, 医師 2018 – 2019: 筑波大学, 医学医療系, 教授 2011 – 2016: 筑波大学, 医学医療系, 教授 2010: 筑波大学, 大学院・人間総合科学研究科, 教授 2007 – 2008: 筑波大学, 大学院・人間総合科学研究科, 教授 2005: University of Tsukuba, Graduate school, professor, 大学院, 教授
Review Section/Research Field	Principal Investigator Applied pharmacology / Basic Section 50020:Tumor diagnostics and therapeutics-related Except Principal Investigator Gastroenterology / Applied pharmacology / Digestive surgery / Laboratory medicine
Keywords	Principal Investigator p53 / MDM2 / p53腫瘍抑制遺伝子 / TP53変異細胞 / iASPP / ΔNp73 / p73活性化 / がん / p73 / SIRT1 / siRNA / 胃癌 … More Except Principal Investigator … More 腫瘍融解ウイルス / 個別化医療 / 糖鎖分子マーカー / レクチン / 胆道系悪性腫瘍 / opioid receptor / pharmacogenetics / morphine / UGT2B7 / オピオイド受容体 / 遺伝子多型 / モルヒネ / ソラフェニブ / ワクシニアウイルス / 癌幹細胞 / 肝細胞癌 / 胆道癌 / 遺伝子化学療法 / UPRT / 5-fluorouracil / サイクロフォスファマイド / アデノウイルス / 遺伝子治療 Less

A research for gastrointestinal cancer treatment targeting EGFR-p53 pathwayPrincipal Investigator
- Principal Investigator
  
  HYODO ICHINOSUKE
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  National Hospital Organization Shikoku Cancer Center
  University of Tsukuba
A basic research of p73 activation as a novel treatment for p53-mutant type cancerPrincipal Investigator
- Principal Investigator
  
  HYODO Ichinosuke
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  University of Tsukuba
Evaluation of cytotoxic effects of oncolytic vaccinia virus on cancer stem cells of liver cancers.
- Principal Investigator
  
  Abei Masato
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Tsukuba
Potent in vitro and in vivo antitumor effects of MDM2 inhibitor nutlin-3 in gastric cancer cellsPrincipal Investigator
- Principal Investigator
  
  HYODO Ichinosuke
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  University of Tsukuba
Evaluation of efficacy and safety of gene-chemotherapy for biliary cancers using oncolytic adenovirus armed with UPRT
- Principal Investigator
  
  ABEI Masato
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Tsukuba
胆道系悪性腫瘍の個別化医療に向けたレクチンアレイによる糖鎖分子マーカーの探索
- Principal Investigator
  
  正田純一
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  University of Tsukuba
肝内結石症からの胆道発癌プロセスと糖鎖分子マーカー活用による肝内胆管癌の早期診断
- Principal Investigator
  
  遠藤隆志
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  University of Tsukuba
Effects of morphine-related genotypes on the individualized morphine treatment in cancer patients
- Principal Investigator
  
  OHASHI Kyoichi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Oita University
  Hamamatsu University School of Medicine

All 2021 2015 2014 2013 2012 2011 2010 2005

All Journal Article Presentation

[Journal Article] MDM4 as a Prognostic Factor for Patients With Gastric Cancer With Low Expression of p53.2021
- Author(s)
  Zhang X, Yamamoto Y, Wang X, Sato M, Imanishi M, Sugaya A, Hirose M, Endo S, Moriwaki T, Yamato K, Hyodo I
- Journal Title
  
  Anticancer Res.
  
  Volume: 41 Issue: 3 Pages: 1475-1483
- DOI
  10.21873/anticanres.14906
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07288
[Journal Article] Enhanced G1 arrest and apoptosis via MDM4/MDM2 double knockdown and MEK inhibition in wild-type TP53 colon and gastric cancer cells with aberrant KRAS signaling2021
- Author(s)
  Wang X, Yamamoto Y, Imanishi M, Zhang X, Sato M, Sugaya A, Hirose M, Endo S, Natori Y, Moriwaki T, Yamato K, Hyodo I
- Journal Title
  
  Oncology Letters
  
  Volume: -
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07288
[Journal Article] Identification of a unique hepatocellular carcinoma line, Li-7, with CD13(+) cancer stem cells hierarchy and population change upon its differentiation during culture and effects of sorafenib.2015
- Author(s)
  Takeshi Yamada, Masato Abei, Inaho Danjoh, Ryoko Shiota, Taro Yamashuita, Ichinosuke Hyodo, Yukio Nakamura.
- Journal Title
  
  BMC Cancer
  
  Volume: 15 Issue: 1 Pages: 260-260
- DOI
  10.1186/s12885-015-1297-7
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460975
[Journal Article] Cyclophosphamide enhances antitumor efficacy of oncolytic adenovirus expressing uracil phosphoribosyltransferase (UPRT) in immunocompetent Syrian hamsters2013
- Author(s)
  Hasegawa N, Abei M, Yokoyama KK, Fukuda K, Seo E, Kawashima R, Nakano Y, Yamada T, Nakade K, Hamada H, Obata Y, Hyodo I
- Journal Title
  
  Int. J.Cancer
  
  Volume: PMID: 23444104(印刷中) Issue: 6 Pages: 1479-1488
- DOI
  10.1002/ijc.28132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590755, KAKENHI-PROJECT-23501277
[Journal Article] EpCAM- and EGFR- targeted selective gene therapy for biliary cancers using Z33-fiber modified adenovirus2011
- Author(s)
  Kawashima R, Abei M, Fukuda K, Nakamura K, Murata T, Wakayama M, Seo E, Hasegawa N, Mizuguchi H, Obata Y, Hyodo I, Hamada H, Yokoyama KK
- Journal Title
  
  Int. J. Cancer
  
  Volume: 129巻 Pages: 1244-1253
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590755
[Journal Article] Potent in vitroand in vivo anti-tumor effects of MDM2 inhibitor nutlin-3 in gastric cancer cells2011
- Author(s)
  Endo S, Yamato K, Hirai S, MoriwakiT, Fukuda K, Suzuki H, Abei M, Nakagawa I, Hyodo I.
- Journal Title
  
  Cancer Sci
  
  Volume: 102(3) Pages: 605-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590497
[Journal Article] Potent in vitro and in vivo antitumor effects of MDM2 inhibitor nutlin-3 in gastric cancer cells.2011
- Author(s)
  Endo S, Hyodo I, et al.
- Journal Title
  
  Cancer Science
  
  Volume: 102 Pages: 605-613
- NAID
  10029291334
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590497
[Journal Article] Effect of opioid- μ receptor genotype on clinical effect of morphine2005
- Author(s)
  Tateishi M, Uchida S, Eguchi K, Hyodo I, Oashi K
- Journal Title
  
  Jap J Clin Pharmacol Ther 36 Suppl
  
  Pages: 185-185
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590436
[Journal Article] モルヒネの薬効におけるμ受容体遺伝子多型2005
- Author(s)
  立石正登, 内田信也, 江口研二, 兵頭一之介, 大橋京一
- Journal Title
  
  臨床薬理 36Suppl
  
  Pages: 185-185
- Data Source
  KAKENHI-PROJECT-16590436
[Journal Article] モルヒネの薬効におけるμ受容体遺伝子多型2005
- Author(s)
  立石正登, 内田信也, 江口研二, 兵頭一之介, 大橋京一
- Journal Title
  
  臨床薬理 36 Suppl
  
  Pages: 185-185
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590436
[Presentation] Identification of A Hepatocellular Carcinoma Cell Line, Li-7, Capable of Monitoring The Differentiation of CD13(+)CD166(-) Cancer Stem Cells And Effects of Sorafenib.2015
- Author(s)
  Takeshi Yamada, Masato Abei M, Inaho Danjoh, Ichinosuke Hyodo, Yukio Nakamura.
- Organizer
  米国癌学会(AACR)2015
- Place of Presentation
  米国フィラデルフィア，ペンシルバニアコンベンションセンター
- Year and Date
  2015-04-20
- Data Source
  KAKENHI-PROJECT-25460975
[Presentation] Identification of A Hepatocellular Carcinoma Cell Line, Ki-7, Capable of Monitoring the Differentiation of CD13(+)CD166(-) Cancer Stem Cells and Effects of Sorafenib.2015
- Author(s)
  Takeshi Yamada, Masato Abei, Inaho Danjoh, Ryoko Shiota, Taro Yamashita, Ichinosuke Hyodo, Yukio Nakamura.
- Organizer
  米国癌学会(AACR)2015
- Place of Presentation
  米国フィラデルフィア，ペンシルバニアコンベンションセンター
- Year and Date
  2015-04-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460975
[Presentation] A hepatocellular carcinoma (HCC) line able to monitor cancer stem cells differentiation and the effects of drugs targeting CSC.2014
- Author(s)
  Takeshi Yamada, Masato Abei M, Inaho Danjoh, Ichinosuke Hyodo, Yukio Nakamura.
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PROJECT-25460975
[Presentation] UPRT遺伝子武装腫瘍融解アデノウイルスを用いた膵癌の遺伝子化学療法の基礎的検討 (2): シクロフォスファミドによる免疫抑制との併用効果2013
- Author(s)
  長谷川直之,安部井誠人,福田邦明,兵頭一之介
- Organizer
  第99回日本消化器病学会総会
- Place of Presentation
  かごしま県民交流センター,鹿児島
- Year and Date
  2013-03-21
- Data Source
  KAKENHI-PROJECT-22590755
[Presentation] UPRT遺伝子武装腫瘍融解アデノウイルスを用いた膵癌の遺伝子化学療法の基礎的検討 (1):免疫適格同種ハムスター膵癌モデルにおける有効性と安全性の評価2013
- Author(s)
  長谷川直之,安部井誠人,福田邦明,兵頭一之介
- Organizer
  第99回日本消化器病学会総会
- Place of Presentation
  かごしま県民交流センター,鹿児島
- Year and Date
  2013-03-21
- Data Source
  KAKENHI-PROJECT-22590755
[Presentation] 胃癌におけるMDM2及びp53蛋白発現の免疫組織学的検討2012
- Author(s)
  兵頭　一之介
- Organizer
  日本消化器病学会
- Place of Presentation
  神戸国際会議場（神戸市）
- Data Source
  KAKENHI-PROJECT-22590497
[Presentation] Efficacy and safety of oncolytic adenovirus combined with UPRT/5-FU suicide gene system: Evaluation in syngenic pancreas cancer model in immunocompetent,adenovirus-permissive Syrian hamsters.2012
- Author(s)
  Hasegawa N, Abei M, Fukuda K,Kawashima R,Seo E, WakayamaM, Hamada H, Yokoyama KK, Obata Y, Hyodo I
- Organizer
  第18回日本遺伝子治療学会総会
- Place of Presentation
  熊本テルサ,熊本
- Year and Date
  2012-06-29
- Data Source
  KAKENHI-PROJECT-22590755
[Presentation] Efficacy and safety of gene-chemo therapy using oncolytic adenovirus expressing uracil phosphoribosyl transferase (UPRT) followed by 5-fluorouracil administration in syngenic pancreatic and biliary cancers in immunocompetent adenoviruspermissive Syrian ha2012
- Author(s)
  Hasegawa N, Abei M, Fukuda K,SeoE, Wakayama M, KawashimaR, Murata T, Hamada H, YokoyamaKK, Obata Y, Hyodo I.
- Organizer
  第15回米国遺伝子・細胞治療学会
- Place of Presentation
  ペンシルベニア・コンベンションセンター,フィラデルフィア,アメリカ合衆国
- Year and Date
  2012-05-17
- Data Source
  KAKENHI-PROJECT-22590755
[Presentation] Targeted and armed oncolytic vaccinia virus JX-594 for treating advanced liver cancers: Recent advances in global clinical trials and our clinical trial plan in Japan.2012
- Author(s)
  Abei, M, Hyodo I, Kirn DH
- Organizer
  第18回日本遺伝子治療学会総会
- Place of Presentation
  熊本テルサ,熊本
- Year and Date
  2012-06-30
- Data Source
  KAKENHI-PROJECT-22590755
[Presentation] Immunosuppression enhances the Efficacy of oncolytic adenovirus-mediated uracil phosphoribosyl Transferase (UPRT)/ 5-fluorouracil suicide gene therapy in immunocompetent adenoviruspermissive Syrian hamsters2012
- Author(s)
  Hasegawa N, Abei M, Fukuda K,Seo E,Wakayama M, Kawashima R, Hamada H, Yokoyama KK, Obata Y, Hyodo I
- Organizer
  2012国際癌遺伝子・細胞治療学会(ISCGT)
- Place of Presentation
  フラマホテル,シンガポール
- Year and Date
  2012-10-04
- Data Source
  KAKENHI-PROJECT-22590755
[Presentation] The anti-tumor effect of MDM2 antagonist nutlin-3 in gastric cancer cell in vitro and in vivo2010
- Author(s)
  Endo S, Suzuki H, Hirai S, Hyodo I, Yamato K
- Organizer
  第101回米国癌学会第101回米国癌学会
- Place of Presentation
  ワシントン,米国
- Year and Date
  2010-04-20
- Data Source
  KAKENHI-PROJECT-22590497
[Presentation] EpCAM and EGFR-targeted selective gene therapy for biliary cancers using Z33-fiber modified adenovirus.2010
- Author(s)
  Abei M, Kawashima R, Fukuda K, Nakamura K, Murata T,Yokoyama KK,Hamada H, Hyodo I
- Organizer
  第16回日本遺伝子治療学会総会
- Place of Presentation
  栃木県総合文化センター,宇都宮
- Year and Date
  2010-07-02
- Data Source
  KAKENHI-PROJECT-22590755
[Presentation] ヒト胃癌細胞株におけるMDM2阻害剤nutlin-3の抗腫瘍効果について2010
- Author(s)
  遠藤慎治,鈴木英雄,平井祥子,兵頭一之介,大和建嗣
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪国際会議場,大阪市
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-22590497

1. ABEI Masato (20261802)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. 正田純一 (90241827)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 大河内信弘 (40213673)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 平林淳 (40156691)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 山本祥之 (00649288)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. SUZUKI Hideo (00400672)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. FUKUDA Kuniaki (50447257)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
8. HAMADA Hirofumi (00189614)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
9. NAGATA KYOSUKE (40180492)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. YAMASHITA TATSUROU (90377432)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. OHASHI Kyoichi (20137714)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. EGUCHI Kenji (30349336)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
13. UCHIDA Shinya (80372522)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
14. KOTEGAWA Tsutomu (20264343)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 遠藤隆志 (60223690)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 中村幸夫 (60231479)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
17. 遠藤慎治 (40625919)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 大和建嗣 (50174751)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 橋本久邦 (10009558)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. YAMASHITA Taro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 阿部井誠人

# of Collaborated Projects: 0 results

# of Collaborated Products: 14 results

Hyodo Ichinosuke 兵頭 一之介

HYODO ICHINOSUKE 兵頭 一之介

HYODO Ichinosuke 兵頭 一之介

兵頭 一之介 ヒョウドウ イチノスケ

Research Projects

Research Products

Co-Researchers

A research for gastrointestinal cancer treatment targeting EGFR-p53 pathwayPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A basic research of p73 activation as a novel treatment for p53-mutant type cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Evaluation of cytotoxic effects of oncolytic vaccinia virus on cancer stem cells of liver cancers.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Potent in vitro and in vivo antitumor effects of MDM2 inhibitor nutlin-3 in gastric cancer cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Evaluation of efficacy and safety of gene-chemotherapy for biliary cancers using oncolytic adenovirus armed with UPRT

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

胆道系悪性腫瘍の個別化医療に向けたレクチンアレイによる糖鎖分子マーカーの探索

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

肝内結石症からの胆道発癌プロセスと糖鎖分子マーカー活用による肝内胆管癌の早期診断

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effects of morphine-related genotypes on the individualized morphine treatment in cancer patients

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] MDM4 as a Prognostic Factor for Patients With Gastric Cancer With Low Expression of p53.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Enhanced G1 arrest and apoptosis via MDM4/MDM2 double knockdown and MEK inhibition in wild-type TP53 colon and gastric cancer cells with aberrant KRAS signaling2021

Author(s)

Journal Title

Data Source

[Journal Article] Identification of a unique hepatocellular carcinoma line, Li-7, with CD13(+) cancer stem cells hierarchy and population change upon its differentiation during culture and effects of sorafenib.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cyclophosphamide enhances antitumor efficacy of oncolytic adenovirus expressing uracil phosphoribosyltransferase (UPRT) in immunocompetent Syrian hamsters2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] EpCAM- and EGFR- targeted selective gene therapy for biliary cancers using Z33-fiber modified adenovirus2011

Author(s)

Journal Title

Data Source

[Journal Article] Potent in vitroand in vivo anti-tumor effects of MDM2 inhibitor nutlin-3 in gastric cancer cells2011

Author(s)

Hyodo Ichinosuke 兵頭一之介

HYODO ICHINOSUKE 兵頭一之介

HYODO Ichinosuke 兵頭一之介

兵頭一之介ヒョウドウイチノスケ