Yamada Yuma 山田勇磨

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YAMADA Yuma 山田勇磨

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Researcher Number	60451431
Other IDs
External Links
Affiliation (Current)	2025: 北海道大学, 薬学研究院, 教授
Affiliation (based on the past Project Information) *help	2023 – 2025: 北海道大学, 薬学研究院, 教授 2016 – 2022: 北海道大学, 薬学研究院, 准教授 2016: 北海道大学, 薬学研究院, 助教 2015 – 2016: 北海道大学, 薬学研究科(研究院), 准教授 2012 – 2015: 北海道大学, 薬学研究科(研究院), 助教 2008 – 2011: Hokkaido University, 大学院・薬学研究院, 助教 2007: Hokkaido University, 大学院・薬学研究院, 助手
Review Section/Research Field	Principal Investigator Biomedical engineering/Biomaterial science and engineering / Medium-sized Section 90:Biomedical engineering and related fields / Biomedical engineering/Biological material science / Basic Section 90120:Biomaterials-related / Biomedical engineering and related fields / Medical pharmacy Except Principal Investigator Transformative Research Areas, Section (III) / Basic Section 53020:Cardiology-related / Otorhinolaryngology / Biological Sciences … More / Broad Section D / Basic Section 54010:Hematology and medical oncology-related / Basic Section 28030:Nanomaterials-related / Basic Section 45020:Evolutionary biology-related / Medium-sized Section 37:Biomolecular chemistry and related fields / Medium-sized Section 47:Pharmaceutical sciences and related fields / Medium-sized Section 90:Biomedical engineering and related fields / Bio-related chemistry / Anesthesiology / Endocrinology / Pediatrics / Drug development chemistry / Medical pharmacy / Biomedical engineering/Biological material science Less
Keywords	Principal Investigator ミトコンドリア / 薬物送達システム / 薬学 / 遺伝子治療 / イメージング / ナノカプセル / ゲノム編集 / 薬物送達学 / 遺伝子送達 / ナノテクノロジー … More / バイオテクノロジー / 細胞内動態制御 / タンパク質送達 / ナノマシン / 癌 / 脳疾患 / オルガネラ製剤 / 移植 / 共生 / 薬物送達 / オートファジー / 発現制御 / 細胞・動物 / 細胞・組織 / 共焦点顕微鏡 / 共焦点レーザースキャン顕微鏡 … More Except Principal Investigator ミトコンドリア / siRNA / ゲノム編集 / DDS / 活性酸素 / ナノキャリア / 遺伝子治療 / MEND / 量子ドット / 三次元培養 / LNP / ナノ医療 / 薬物送達 / ミトコンドリア心筋症 / 心筋症 / 呼吸鎖酵素活性 / 電子顕微鏡 / 細胞内動態制御 / 抗腫瘍効果 / ワクチン / ハイドロダイナミクス法 / 多機能性エンベロープ型ナノ構造体 / がん / がん治療 / オクタアルギニン / タンパク質導入 / 遺伝子送達 / ペプチド / 細胞内共生 / ミトコンドリアゲノム / 葉緑体ゲノム / オルガネラゲノム / オルガネラ / 葉緑体 / 細胞質ゲノム / 腫瘍血管 / mRNA / スマートポリマー / エネルギー代謝 / Gilteriinib / R-Spondin / 慢性GVHD / 白血病 / 幹細胞 / CAR-T / 疲弊T細胞 / 炎症記憶 / 造血幹細胞移植 / FLT3阻害剤 / IFN-α / カルシニューリン阻害剤 / T細胞疲弊 / 腸幹細胞 / GVL / GVHD / 周囲炎 / 発光材料 / 電子ドナー・アクセプター分子 / コアシェル型量子ドット / インプラント周囲炎 / 光増感剤 / 量子ドット凝集体 / 3次元培養細胞系 / 光線力学効果 / 光線温熱効果 / 近赤外光 / 光がん治療薬 / ロングリードシークエンス / ナノカプセル / 外来生物 / マルチオミックス / ミトコンドリア標的型リポソーム / ツメガエル / シロアゴガエル / 進化 / 光線力学療法 / 半導体量子ドット / 光線がん治療 / 膵癌（膵臓がん） / 細胞死 / すい臓癌 / 光機能性分子 / 光励起 / 一重項酸素 / 光がん治療 / スフェロイド / アポトーシス / 光治療 / 物理系薬学 / リポソーム / pH / 生物物理 / 光 / ロドプシン / ナノＤＤＳ / 核酸送達 / 脂質ナノ粒子 / 細胞内局在 / ミトコンドリア遺伝子治療 / がん免疫療法 / ナノDDS / 核酸ナノ医療 / ナノ医薬品 / がん免疫 / 律速段階 / 核酸医薬 / 呼吸鎖酵素複合体 / 免疫組織病理 / 病理診断法 / 免疫染色法 / Stereology / 細胞内酸化還元現象 / 光酸化還元反応 / 光線療法 / スーパーオキシド / 金属内包フラーレン / ポルフィリン / フラーレン / 光誘起電荷分離分子 / Drug Delivery System / 虚血再灌流傷害 / 心停止蘇生 / 肥満 / FGF21 / オルガネラネットワーク / メタボリックシンドローム / 糖代謝 / Mff / Drp1 / ミトコンドリアダイナミクス / DRP１ / DRP1 / 小胞体ストレス / 糖尿病 / ドラッグデリバリー / 内耳 / 血液内耳関門 / 内耳蝸牛 / イメージング / ステレオロジー / 聴覚 / アミノグリコシド / 難聴 / MITO-Porter / iPS細胞 / ヒトiPS細胞 / アミノグリコシド系抗生剤 / 機能性核酸 / KALA / 核送達 / パッケージング / バイセル / 自己活性化システム / ミトコンドリア送達 / 還元環境応答性 / pH-感受性カチオニック脂質 / ナノパッケージング / 核内動態制御 / マイクロ流路 / ナノマシン / 抗原提示 / MHCクラス-I / 細胞透過性ペプチド / 細胞性免疫 / ナノ構造体 / トポロジー / アジュバント / エンドソーム脱出 / PPD / デリバリーシステム / R8-NEND / カベオラ / IRO / GALA / 遺伝子デリバリーシステム / 遺伝子診断 / 網羅的解析 / 2型糖尿病 / 血管透過 / トランスサイトーシス / エンドサイトーシス / 遺伝子デリバリー / PPD-MEND / MMP / 遺伝子導入 Less

Development of Phototherapeutic Drugs and Elucidation of Single Molecule Dynamics Using Highly Bright Stable Quantum Dots and Innovative 3D cell system
- Principal Investigator
  
  Takano Yuta
- Project Period (FY)
  2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 28030:Nanomaterials-related
- Research Institution
  Hokkaido University
Study on mechanisms of immune and tissue tolerance after allogeneic hematopoietic stem cell transplantation
- Principal Investigator
  
  Teshima Takanori
- Project Period (FY)
  2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Hokkaido University
Genomic regulation of intracellular symbiotic organelles: from technological innovation to understanding and application of life phenomena
- Principal Investigator
  
  有村慎一
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  The University of Tokyo
オルガネラへの核酸および生理活性分子導入
- Principal Investigator
  
  沼田圭司
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Kyoto University
小児の心筋症におけるミトコンドリア障害と心筋エネルギー代謝に関する研究
- Principal Investigator
  
  武田充人
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Hokkaido University
Activated mRNA delivery system based on core-shell structured LNP with smart polymers
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section D
- Research Institution
  Hokkaido University
ミトコンドリア遺伝子治療を実現するゲノム編集技術の創出Principal Investigator
- Principal Investigator
  
  山田勇磨
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Hokkaido University
Functional background of mitochondrial genome evolution unraveled from the atp8 gene of Polypedates leucomystax
- Principal Investigator
  
  Yasuoka Yuuri
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 45020:Evolutionary biology-related
- Research Institution
  Institute of Physical and Chemical Research
Development of Mitochondria-Targeted Nanocapsules for the Treatment of Neurological DisordersPrincipal Investigator
- Principal Investigator
  
  Yamada Yuma
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Hokkaido University
Development of Trojan horse-type cancer therapeutics by elucidating and utilizing the predation mechanism of pancreatic cancer cells
- Principal Investigator
  
  Takano Yuta
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 37:Biomolecular chemistry and related fields
- Research Institution
  Hokkaido University
Production of novel drug derivery system with light-induced disruption of liposomes (LiDL)
- Principal Investigator
  
  Sudo Yuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Okayama University
Development of artificial mitochondria with cell-symbiosis abilityPrincipal Investigator
- Principal Investigator
  
  Yamada Yuma
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Hokkaido University
Development of a nano device for mitochondrial gene editingPrincipal Investigator
- Principal Investigator
  
  Yamada Yuma
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Hokkaido University
Establishment of the new diagnostic method in mitochondrial cardiomyopathy
- Principal Investigator
  
  Takeda Atsuhito
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Hokkaido University
Innovative gene/nucleic acid delivery system based on optimized intracellular trafficking steps
- Principal Investigator
  
  HARASHIMA HIDEYOSHI
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Hokkaido University
Drug discovery of nano-molechule mitochondria targeted agent and impact on post cardiac arrest brain injury
- Principal Investigator
  
  Kohei Ikeda
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology
- Research Institution
  Jikei University School of Medicine
Development of a nano device to investigate mitochondrial quality controlPrincipal Investigator
- Principal Investigator
  
  Yamada Yuma
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Biomedical engineering and related fields
- Research Institution
  Hokkaido University
Construction of nanocapsule targeting mutated mitochondria for gene therapyPrincipal Investigator
- Principal Investigator
  
  Yamada Yuma
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Hokkaido University
Investigation into unraveling the mechanism of drug delivery system to the inner ear
- Principal Investigator
  
  Kita Tomoko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Kyoto University
Establishment of diagnostic procedure and the new diagnostic criteria of mitochondrial cardiomyopathy based on an Imaging technology
- Principal Investigator
  
  Takeda Atsuhito
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Hokkaido University
Development of a nanoparticle to release nucleic acids in a mitochondrial environmentPrincipal Investigator
- Principal Investigator
  
  YAMADA Yuma
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Hokkaido University
Development of optical control method of cell organelle function by photoindeuced charge separation molecule
- Principal Investigator
  
  Takano Yuta
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bio-related chemistry
- Research Institution
  Hokkaido University
  Kyoto University
Development of nanomachine for mitochondrial gene therapy targeted to cells derived from mitochondrial disease patientsPrincipal Investigator
- Principal Investigator
  
  YAMADA Yuma
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Hokkaido University
New approach for the mechanism of ototoxic drugs against the mtDNA1555AG mutation - human iPSC and nanocarieer-
- Principal Investigator
  
  Kitajiri Shinichiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Kyoto University
Elucidation of organelle network mechanism controlled by mitochondrial dynamics and its application.
- Principal Investigator
  
  Nomura Masatoshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Kyushu University
Development of nano device for regulating mitochondrial gene expressionPrincipal Investigator
- Principal Investigator
  
  YAMADA Yuma
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Hokkaido University
Development of in vivo mitochondrial gene delivery system and validation of mitochondrial exogenous gene expression in skeletal musclePrincipal Investigator
- Principal Investigator
  
  YAMADA Yuma
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Hokkaido University
MENDで拓く遺伝子治療への道：遺伝子の運び屋からナノマシンへ
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Drug development chemistry
- Research Institution
  Hokkaido University
Development of Multi-layered nano-device for mitochondrial drug delivery and an innovative approach for mitochondrial disease' therapyPrincipal Investigator
- Principal Investigator
  
  YAMADA Yuma
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Hokkaido University
Multifunctional Envelope-type Nano Device as non-viral gene delivery system for cancer therapy
- Principal Investigator
  
  HARASHIMA Hideyoshi
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
抗原提示バランスとアジュバントの制御に基づいたオーダーメイド癌ワクチン
- Principal Investigator
  
  原島秀吉
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Hokkaido University
Development of Multi-layered nano-device for mitochondrial drugdelivery and mitochondrial protein delivery for cancer therapyPrincipal Investigator
- Principal Investigator
  
  YAMADA Yuma
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Medical pharmacy
- Research Institution
  Hokkaido University
がん選択的多機能性エンベロープ型ナノ構造体の開発とがん遺伝子治療への応用
- Principal Investigator
  
  HARASHIMA Hideyoshi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
Development of in vivo gene delivery system for siRNA and genome wide screening of type-two diabetes related genes in mice and rats
- Principal Investigator
  
  HARASHIMA Hideyoshi
- Project Period (FY)
  2006 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Hokkaido University

[Book] Nanomedicines for Effective Cancer Therapy、Cancer Photo Therapies that Target Mitochondri、2024
- Author(s)
  Yuma Yamada, Fumika Kubota, Rina Naganawa, Satrialdi & Hideyoshi Harashima
- Total Pages
  19
- Publisher
  Springer Nature
- ISBN
  9789819752874
- Data Source
  KAKENHI-ORGANIZER-24H02270
[Book] ミトコンドリアダイナミクス. 第2編、第1章、第5節2021
- Author(s)
  山田勇磨、原島秀吉
- Total Pages
  381
- Publisher
  株式会社エヌ・ティー・エス
- ISBN
  9784860437466
- Data Source
  KAKENHI-PROJECT-19H01170
[Book] “Pharmacology of Mitochondria” Handb Exp Pharmacol2017
- Author(s)
  Yamada Y, Harashima H.
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-15K12532
[Book] “Pharmacology of Mitochondria” Handb Exp Pharmacol2017
- Author(s)
  Yamada Y, Harashima H.
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-26282131
[Book] Handbook of Experimental Pharmacology2016
- Author(s)
  Yamada Y, Harashima H.
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-26670741
[Book] Innovative Medicine2015
- Author(s)
  Michitaka Ozaki, Takeaki Ozawa, Yuma Yamada
- Total Pages
  339
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-26282131
[Book] Innovative Medicine2015
- Author(s)
  Michitaka Ozaki, Takeaki Ozawa, Yuma Yamada
- Total Pages
  339
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-15K12532
[Book] Nonviral Vectors for Gene Therapy (Vol. 88): Lipid- and Polymer-based Gene Transfer2014
- Author(s)
  Yusuke Sato, Takashi Nakamura, Yuma Yamada, Hidetaka Akita, Hideyoshi Harashima
- Total Pages
  428
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-25560219
[Book] Nonviral Vectors for Gene Therapy (Vol. 88): Lipid- and Polymer-based Gene Transfer2014
- Author(s)
  Yusuke Sato, Takashi Nakamura, Yuma Yamada, Hidetaka Akita, Hideyoshi Harashima
- Total Pages
  428
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-26282131
[Book] 応用が拡がるＤＤＳ2013
- Author(s)
  秋田英万、山田勇磨、畠山浩人、林泰弘、原島秀吉
- Total Pages
  578
- Publisher
  株式会社エヌ・ティー・エス
- Data Source
  KAKENHI-PROJECT-25560219
[Book] 応用が拡がるＤＤＳ.2013
- Author(s)
  秋田英万、山田勇磨、畠山浩人、林泰弘、原島秀吉.
- Total Pages
  578
- Publisher
  株式会社エヌ・ティー・エス
- Data Source
  KAKENHI-PROJECT-23680053
[Book] 応用が拡がるDDS2013
- Author(s)
  秋田英万、山田勇磨、畠山浩人、林泰弘、原島秀吉
- Total Pages
  578
- Publisher
  株式会社エヌ・ティー・エス
- Data Source
  KAKENHI-PROJECT-23680053
[Book] 人工臓器　「膵島移植とミトコンドリア標的型drug delivery system (DDS)」2012
- Author(s)
  山田勇磨
- Total Pages
  3
- Publisher
  学研メディカル秀潤社
- Data Source
  KAKENHI-PROJECT-23680053
[Book] ペプチド・タンパク性医薬品の新規DDS製剤の開発と応用-遺伝子医学MOOK別冊2011
- Author(s)
  山田勇磨、中村孝司、原島秀吉
- Total Pages
  8
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-22229001
[Book] Delivery of Nucleic Acids and Gene Delivery2011
- Author(s)
  H.Akita, H.Hatakeyama, I.A.Khalil, Y.Yamada, H.Harashima
- Total Pages
  34
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-22229001
[Book] バイオテクノロジーシリーズ蛍光イメージング/MRIプローブの開発2011
- Author(s)
  秋田英万、山田勇磨,中村孝司、畠山浩人、林泰弘、梶本和昭、原島秀吉
- Total Pages
  10
- Publisher
  CMC出版
- Data Source
  KAKENHI-PROJECT-22229001
[Book] Chapter 25 Uptake Pathways Dependent Intracellular Trafficking of DNA Carrying Nanodelivery System(Organelle-Specific Pharmaceutical Nanotechnology, Editors : Volkmar Weissig and Gerard G.M. D'Souza Wiley A John Wiley & Sons, Inc., Publication)2010
- Author(s)
  I.A.Khalil, Y.Yamada, H.Akita, H.Harashima
- Data Source
  KAKENHI-PROJECT-21700483
[Book] Volkmar Weissig and Gerard G.M. D'Souza Wiley A John Wiley & Sons, Inc., Publication2010
- Author(s)
  IA Khalil, Y.Yamada, et al
- Total Pages
  31
- Publisher
  "Chapter 25 Uptake Pathways Dependent Intracellular Trafficking of DNA Carrying Nanodelivery System" Organelle-Specific Pharmaceutical Nanotechnology
- Data Source
  KAKENHI-PROJECT-22229001
[Book] ミトコンドリアへの輸送2008
- Author(s)
  山田勇磨, 原島秀吉
- Publisher
  機能性DDSキャリアの製剤設計シーエムシー出版
- Data Source
  KAKENHI-PROJECT-19890001
[Book] 遺伝子医学MOOK別冊 (編集 : 田畑泰彦) メディカルドゥ2007
- Author(s)
  山田勇磨, 原島秀吉
- Publisher
  ミトコンドリアを標的とする多機能性エンベロープ型ナノ構造体(MEND)の開発
- Data Source
  KAKENHI-PROJECT-19890001
[Book] 多機能性エンベロープ型ナノ構造体(MEND)を基盤とした新規タンパク質DDSの構築と臨床開発研究への応用(ペプチド・タンパク性医薬品の新規DDS製剤の開発と応用-遺伝子医学MOOK別冊)(編集:山本昌)
- Author(s)
  山田勇磨, 中村孝司、原島秀吉
- Publisher
  メディカルドゥ(in press)
- Data Source
  KAKENHI-PROJECT-21700483
[Journal Article] An effective approach to modulate mitochondrial function in murine primary macrophages by a mitochondria-targeted nanocapsule, MITO-Porter2025
- Author(s)
  Hibino Mitsue、Filosi Tobia、Carrion Libia Lara、Porcu Emilio、Malhotra Ankit、Ludtke-Buzug Kerstin、Ibrahim Saleh M.、Yamada Yuma、Hirose Misa
- Journal Title
  
  Biomedicine & Pharmacotherapy
  
  Volume: 186 Pages: 118019-118019
- DOI
  10.1016/j.biopha.2025.118019
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23H00541, KAKENHI-PROJECT-22K19928
[Journal Article] Cubic Phase‐Inducible Zwitterionic Phospholipids Improve the Functional Delivery of mRNA2025
- Author(s)
  Iwakawa Kazuki、Sato Rikako、Konaka Mariko、Yamada Yuma、Harashima Hideyoshi、Sato Yusuke
- Journal Title
  
  Advanced Science
  
  Volume: - Issue: 17
- DOI
  10.1002/advs.202413016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-24H02270, KAKENHI-PROJECT-23H05451
[Journal Article] Marginal-zone B cells as promising targets of an mRNA-loaded, lipid-nanoparticle cancer vaccine2025
- Author(s)
  Suzuki Yuichi、Yakuwa Mai、Sato Mina、Samaridou Eleni、Beck-Broichsitter Moritz、Maeki Masatoshi、Tokeshi Manabu、Yamada Yuma、Harashima Hideyoshi、Sato Yusuke
- Journal Title
  
  Next Nanotechnology
  
  Volume: 8 Pages: 100154-100154
- DOI
  10.1016/j.nxnano.2025.100154
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23H05451, KAKENHI-PROJECT-23K19418, KAKENHI-PROJECT-23KJ0073
[Journal Article] Analysis of the collaboration mode of molecular motors in the vesicle transport system of the Golgi apparatus2025
- Author(s)
  Yuma Yamada
- Journal Title
  
  Cell Biology Research
  
  Volume: 6 Pages: 1-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-24H02270
[Journal Article] Mitochondrial Activation and Therapeutics: Innovations in Cell- and Organelle-Specific Medicine2025
- Author(s)
  Sato I、Shiraishi M、Norota K、Shiraki K、Yamada Yuma
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19928
[Journal Article] Activation of Mitochondrial Oxygen Consumption Rate by Delivering Coenzyme Q10 to Mitochondria of Rat Skeletal Muscle Cell (L6)2024
- Author(s)
  Sato Itsumi、Hibino Mitsue、Takeda Atsuhito、Harashima Hideyoshi、Yamada Yuma
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: - Issue: 7 Pages: 1836-1843
- DOI
  10.1016/j.xphs.2024.01.020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23H05451, KAKENHI-PROJECT-23H00541, KAKENHI-PROJECT-23K07496
[Journal Article] Activation of Mitochondria in Mesenchymal Stem Cells by Mitochondrial Delivery of Coenzyme Q102024
- Author(s)
 Maruo Yuji、Shiraishi Masahiro、Hibino Mitsue、Abe Jiro、Takeda Atsuhito、Yamada Yuma
- Journal Title
 
 Biological and Pharmaceutical Bulletin
 
 Volume: 47 Issue: 8 Pages: 1415-1421
- DOI
 10.1248/bpb.b24-00284
- ISSN
 0918-6158, 1347-5215
- Year and Date
 2024-08-06
- Language
 English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
 KAKENHI-ORGANIZER-24H02270, KAKENHI-PROJECT-23H05451, KAKENHI-PROJECT-23H00541, KAKENHI-PROJECT-22K19928, KAKENHI-PROJECT-23K07496, KAKENHI-PROJECT-24K18992
[Journal Article] Human cardiosphere-derived cells with activated mitochondria for better myocardial regenerative therapy2024
- Author(s)
  Shiraishi Masahiro、Sasaki Daisuke、Hibino Mitsue、Takeda Atsuhito、Harashima Hideyoshi、Yamada Yuma
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 367 Pages: 486-499
- DOI
  10.1016/j.jconrel.2024.01.058
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23H05451, KAKENHI-PROJECT-23H00541
[Journal Article] Different Effects of Berberine Delivery to Mitochondria on Cells Derived from the Neural Crest2024
- Author(s)
  Hori Ikuma、Harashima Hideyoshi、Yamada Yuma
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 47 Issue: 10 Pages: 1726-1733
- DOI
  10.1248/bpb.b24-00463
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2024-10-26
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-24H02270, KAKENHI-PROJECT-22K19928
[Journal Article] π-extended porphyrin-based near-infrared photosensitizers for mitochondria-targeted photodynamic therapy2024
- Author(s)
  Zhao Hanjun、Naganawa Rina、Yamada Yuma、Osakada Yasuko、Fujitsuka Mamoru、Mitomo Hideyuki、Miyatake Yukiko、Harashima Hideyoshi、Biju Vasudevanpillai、Takano Yuta
- Journal Title
  
  Journal of Photochemistry and Photobiology A: Chemistry
  
  Volume: 449 Pages: 115397-115397
- DOI
  10.1016/j.jphotochem.2023.115397
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21067, KAKENHI-PROJECT-23K26474, KAKENHI-ORGANIZER-24H02270
[Journal Article] The impact of, and expectations for, lipid nanoparticle technology: From cellular targeting to organelle targeting2024
- Author(s)
  Sato Yusuke、Nakamura Takashi、Yamada Yuma、Harashima Hideyoshi
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 370 Pages: 516-527
- DOI
  10.1016/j.jconrel.2024.05.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-24H02270, KAKENHI-PROJECT-23H00541, KAKENHI-PROJECT-23K07496
[Journal Article] Investigation of the Nanoparticulation Method and Cell-Killing Effect following the Mitochondrial Delivery of Hydrophobic Porphyrin-Based Photosensitizers2024
- Author(s)
  Naganawa Rina、Zhao Hanjun、Takano Yuta、Maeki Masatoshi、Tokeshi Manabu、Harashima Hideyoshi、Yamada Yuma
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 25 Issue: 8 Pages: 4294-4294
- DOI
  10.3390/ijms25084294
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19928, KAKENHI-PROJECT-23K21067, KAKENHI-ORGANIZER-24H02270, KAKENHI-PROJECT-23H05451, KAKENHI-PROJECT-23K07496
[Journal Article] Investigation of the nanoparticulation method and cell-killing effect following the mitochondrial delivery of hydrophobic porphyrin-based photosensitizers.2024
- Author(s)
  6.Naganawa R, Zhao H, Takano Y, Maeki M, Tokeshi M, Harashima H, Yamada Y
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: -
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23H00541
[Journal Article] A system that delivers an antioxidant to mitochondria for the treatment of drug-induced liver injury2023
- Author(s)
  Hibino Mitsue、Maeki Masatoshi、Tokeshi Manabu、Ishitsuka Yoichi、Harashima Hideyoshi、Yamada Yuma
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 6961-6961
- DOI
  10.1038/s41598-023-33893-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19928, KAKENHI-PROJECT-23H05451, KAKENHI-PROJECT-23H00541
[Journal Article] Development of Liposomes That Target Axon Terminals Encapsulating Berberine in Cultured Primary Neurons2023
- Author(s)
  Hori Ikuma、Harashima Hideyoshi、Yamada Yuma
- Journal Title
  
  Pharmaceutics
  
  Volume: 16 Issue: 1 Pages: 49-49
- DOI
  10.3390/pharmaceutics16010049
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19928, KAKENHI-PROJECT-23H00541
[Journal Article] Development of a Mitochondrial Targeting Lipid Nanoparticle Encapsulating Berberine2023
- Author(s)
  Hori Ikuma、Harashima Hideyoshi、Yamada Yuma
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 2 Pages: 903-903
- DOI
  10.3390/ijms24020903
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19928, KAKENHI-PROJECT-19H01170, KAKENHI-PROJECT-20H04523
[Journal Article] Differences in the Intracellular Localization of Methylated β-Cyclodextrins-Threaded Polyrotaxanes Lead to Different Cellular States2023
- Author(s)
  Yamada Yuma、Daikuhara Shinnosuke、Tamura Atsushi、Nishida Kei、Yui Nobuhiko、Harashima Hideyoshi
- Journal Title
  
  Biomolecules
  
  Volume: 13 Issue: 6 Pages: 903-903
- DOI
  10.3390/biom13060903
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23H00541
[Journal Article] Innovative cancer nanomedicine based on immunology, gene editing, intracellular trafficking control2022
- Author(s)
  Yamada Yuma、Sato Yusuke、Nakamura Takashi、Harashima Hideyoshi
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 348 Pages: 357-369
- DOI
  10.1016/j.jconrel.2022.05.033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03373, KAKENHI-PROJECT-20H04523
[Journal Article] Recent advances in delivering RNA-based therapeutics to mitochondria2022
- Author(s)
  Yamada Yuma、Ishizuka Sen、Arai Manae、Maruyama Minako、Harashima Hideyoshi
- Journal Title
  
  Expert Opinion on Biological Therapy
  
  Volume: 22 Issue: 9 Pages: 1209-1219
- DOI
  10.1080/14712598.2022.2070427
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H04523
[Journal Article] Extrahepatic targeting of lipid nanoparticles in vivo with intracellular targeting for future nanomedicines2022
- Author(s)
  Nakamura Takashi、Sato Yusuke、Yamada Yuma、Abd Elwakil Mahmoud M.、Kimura Seigo、Younis Mahmoud A.、Harashima Hideyoshi
- Journal Title
  
  Advanced Drug Delivery Reviews
  
  Volume: 188 Pages: 114417-114417
- DOI
  10.1016/j.addr.2022.114417
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03373, KAKENHI-PROJECT-20H04523, KAKENHI-PROJECT-21F21105, KAKENHI-PROJECT-21J10047
[Journal Article] Validation of a therapeutic strategy involving the mitochondrial delivery of thiamine pyrophosphate using brain damage induced mouse model2022
- Author(s)
  Yamada Yuma、Ishimaru Takuya、Harashima Hideyoshi
- Journal Title
  
  Clinical and Translational Discovery
  
  Volume: 2 Issue: 2
- DOI
  10.1002/ctd2.43
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H04523
[Journal Article] Fine‐tuning the encapsulation of a photosensitizer in nanoparticles reveals the relationship between internal structure and phototherapeutic effects2022
- Author(s)
  Kubota Fumika、Satrialdi、Takano Yuta、Maeki Masatoshi、Tokeshi Manabu、Harashima Hideyoshi、Yamada Yuma
- Journal Title
  
  Journal of Biophotonics
  
  Volume: 16 Issue: 3
- DOI
  10.1002/jbio.202200119
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01170, KAKENHI-PROJECT-20H04523, KAKENHI-PROJECT-21K19036, KAKENHI-PROJECT-23K21067
[Journal Article] Transplantation of MITO cells, mitochondria activated cardiac progenitor cells, to the ischemic myocardium of mouse enhances the therapeutic effect2022
- Author(s)
  Daisuke Sasaki, Jiro Abe, Atsuhito Takeda, Hideyoshi Harashima and Yuma Yamada
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 4344-4357
- DOI
  10.1038/s41598-022-08583-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08529, KAKENHI-PROJECT-20K21872, KAKENHI-PROJECT-19H01170, KAKENHI-PROJECT-20H04523
[Journal Article] The hydrophobic tail of a pH-sensitive cationic lipid influences siRNA transfection activity and toxicity in human NK cell lines.2021
- Author(s)
  Nakamura T, Nakade T, Yamada K, Sato Y, Harashima H
- Journal Title
  
  Int J Pharm
  
  Volume: 609 Pages: 121140-121140
- DOI
  10.1016/j.ijpharm.2021.121140
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01170, KAKENHI-PROJECT-20H03373
[Journal Article] Validation of the mitochondrial delivery of vitamin B1 to enhance ATP production using SH-SY5Y cells2021
- Author(s)
  Yamada Y, Ishimaru T, Ikeda K, Harashima H
- Journal Title
  
  J. Pharm. Sci.
  
  Volume: 111 Issue: 2 Pages: 432-439
- DOI
  10.1016/j.xphs.2021.08.033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01170, KAKENHI-PROJECT-20H04523
[Journal Article] Resveratrol-Encapsulated Mitochondria-Targeting Liposome Enhances Mitochondrial Respiratory Capacity in Myocardial Cells2021
- Author(s)
  Tsujioka Takao、Sasaki Daisuke、Takeda Atsuhito、Harashima Hideyoshi、Yamada Yuma
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 1 Pages: 112-112
- DOI
  10.3390/ijms23010112
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21872
[Journal Article] An effective in vivo mitochondria-targeting nanocarrier combined with a π-extended porphyrin-type photosensitizer2021
- Author(s)
  Satrialdi、Takano Yuta、Hirata Eri、Ushijima Natsumi、Harashima Hideyoshi、Yamada Yuma
- Journal Title
  
  Nanoscale Advances
  
  Volume: 3 Issue: 20 Pages: 5919-5927
- DOI
  10.1039/d1na00427a
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H04523, KAKENHI-PROJECT-20K10025, KAKENHI-PROJECT-21K19036, KAKENHI-PROJECT-23K21067
[Journal Article] Power of mitochondrial drug delivery systems to produce innovative nanomedicines2020
- Author(s)
  Yamada Y, Satrialdi, Hibino M, Sasaki D, Jiro A, Harashima H
- Journal Title
  
  Adv. Drug. Deliv. Rev.
  
  Volume: 154-155 Pages: 187-209
- DOI
  10.1016/j.addr.2020.09.010
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21872, KAKENHI-PROJECT-20H04523
[Journal Article] Challenges in promoting mitochondrial transplantation therapy.2020
- Author(s)
  Yamada Y, Ito M, Arai M, Hibino M, Tsujioka T, Harashima H
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 17 Pages: 6365-6365
- DOI
  10.3390/ijms21176365
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21872
[Journal Article] Validation of a mitochondrial RNA therapeutic strategy using fibroblasts from a Leigh syndrome patient with a mutation in the mitochondrial ND3 gene2020
- Author(s)
  Yamada Y, Somiya K, Miyauchi A, Osaka H, Harashima H
- Journal Title
  
  Sci. Rep
  
  Volume: - Issue: 1 Pages: 7511-7511
- DOI
  10.1038/s41598-020-64322-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H02094, KAKENHI-PROJECT-19H01170, KAKENHI-PROJECT-20H03648, KAKENHI-PROJECT-20H04523
[Journal Article] Development of a nanoparticle that releases nucleic acids in response to a mitochondrial environment.2020
- Author(s)
  Yamada Y, Fukuda Y, Sasaki D, Maruyama M, Harashima H
- Journal Title
  
  Mitochondrion
  
  Volume: 52 Pages: 67-74
- DOI
  10.1016/j.mito.2020.02.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H02094, KAKENHI-PROJECT-19H01170
[Journal Article] Validation of gene therapy for mutant mitochondria by delivering mitochondrial RNA using a MITO-Porter, a liposome-based nano device2020
- Author(s)
  Kawamura E, Maruyama M, Abe J, Sudo A, Takeda A, Takada S, Yokota T, Kinugawa S, Harashima H, Yamada Y
- Journal Title
  
  Mol. Ther. - Nucleic Acids
  
  Volume: - Pages: 687-698
- DOI
  10.1016/j.omtn.2020.04.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H02094, KAKENHI-PROJECT-19K22791, KAKENHI-PROJECT-20H04523
[Journal Article] Lipid nanoparticles fuse with cell membranes of immune cells at low temperatures leading to the loss of transfection activity2020
- Author(s)
  Nakamura T, Yamada K, Sato Y, Harashima H.
- Journal Title
  
  Int J Pharm.
  
  Volume: 587 Pages: 119652-119652
- DOI
  10.1016/j.ijpharm.2020.119652
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01170
[Journal Article] The optimization of cancer photodynamic therapy by utilization of a pi-extended porphyrin-type photosensitizer in combination with MITO-Porter2020
- Author(s)
  Satrialdi, Munechika R, Biju V, Takano Y, Harashima H, Yamada Y.
- Journal Title
  
  ChemCommun.
  
  Volume: 56 Issue: 7 Pages: 1145-1148
- DOI
  10.1039/c9cc08563g
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H02094, KAKENHI-PROJECT-19H02550, KAKENHI-PROJECT-16H06280
[Journal Article] The use of a MITO-Porter to deliver exogenous therapeutic RNA to a mitochondrial disease’s cell with a A1555G mutation in the mitochondrial 12S rRNA gene results in an increase in mitochondrial respiratory activity2020
- Author(s)
  Yamada Yuma、Maruyama Minako、Kita Tomoko、Usami Shin-ichi、Kitajiri Shin-ichiro、Harashima Hideyoshi
- Journal Title
  
  Mitochondrion
  
  Volume: 55 Pages: 134-144
- DOI
  10.1016/j.mito.2020.09.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09867, KAKENHI-PROJECT-20K09687, KAKENHI-PROJECT-20H04523
[Journal Article] The use of a microfluidic device to encapsulate a poorly water-soluble drug CoQ10 in lipid nanoparticles and an attempt to regulate intracellular trafficking to reach mitochondria2019
- Author(s)
  Hibino Mitsue、Yamada Yuma、Fujishita Naoki、Sato Yusuke、Maeki Masatoshi、Tokeshi Manabu、Harashima Hideyoshi
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 印刷中 Issue: 8 Pages: 2668-2676
- DOI
  10.1016/j.xphs.2019.04.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H02094, KAKENHI-PROJECT-16K11180, KAKENHI-PROJECT-17K20076
[Journal Article] A mitochondrial delivery system using liposome-based nanocarriers that target myoblast cells2019
- Author(s)
  Katayama Takashi、Kinugawa Shintaro、Takada Shingo、Furihata Takaaki、Fukushima Arata、Yokota Takashi、Anzai Toshihisa、Hibino Mitsue、Harashima Hideyoshi、Yamada Yuma
- Journal Title
  
  Mitochondrion
  
  Volume: 49 Pages: 66-72
- DOI
  10.1016/j.mito.2019.07.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22791, KAKENHI-PROJECT-17H02094, KAKENHI-PROJECT-18H03187, KAKENHI-PROJECT-17H04758
[Journal Article] Innovative nanotechnologies for enhancing nucleic acids/gene therapy: Controlling intracellular trafficking to targeted biodistribution2019
- Author(s)
  Nakamura Takashi, Yamada Yuma, Sato Yusuke, Khalil A Ikramy, Harashima Hideyoshi
- Journal Title
  
  Biomaterials
  
  Volume: 218 Pages: 119329-119329
- DOI
  10.1016/j.biomaterials.2019.119329
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19888, KAKENHI-PROJECT-19H01170, KAKENHI-PROJECT-17H02094, KAKENHI-PROJECT-17H03974, KAKENHI-PROJECT-17H05052, KAKENHI-PROJECT-18K19889
[Journal Article] A Nanocarrier System for Mitochondrial Delivery Targeted to a Pancreatic Beta Cell2019
- Author(s)
  Yamada Yuma
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 139 Issue: 1 Pages: 41-45
- DOI
  10.1248/yakushi.18-00163-1
- NAID
  130007541687
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2019-01-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H02094, KAKENHI-PROJECT-17K20076
[Journal Article] Enhanced autophagy induction via the mitochondrial delivery of methylated β-cyclodextrin-threaded polyrotaxanes using a MITO-Porter2019
- Author(s)
  Yamada Yuma、Daikuhara Shinnosuke、Tamura Atsushi、Nishida Kei、Yui Nobuhiko、Harashima Hideyoshi
- Journal Title
  
  Chemical Communications
  
  Volume: 55 Issue: 50 Pages: 7203-7206
- DOI
  10.1039/c9cc03272j
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H02094, KAKENHI-PROJECT-16H05910, KAKENHI-PROJECT-18K19904
[Journal Article] ミトコンドリアを標的とする遺伝子治療用ナノカプセルの創製2019
- Author(s)
  山田勇磨
- Journal Title
  
  日本核酸医薬学会会誌
  
  Volume: - Pages: 12-21
- NAID
  40022467016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H02094
[Journal Article] ミトコンドリアDDSが拓く新しいミトコンドリア病治療戦略2019
- Author(s)
  山田勇磨、原島秀吉
- Journal Title
  
  小児科診療
  
  Volume: 823 Pages: 523-528
- Data Source
  KAKENHI-PROJECT-17H02094
[Journal Article] Targeted mitochondrial delivery of antisense RNA-containing nanoparticles by a MITO-Porter for safe and efficient mitochondrial gene silencing.2019
- Author(s)
  396.Kawamura E, Hibino M, Harashima H, Yamada Y.
- Journal Title
  
  Mitochondrion.
  
  Volume: 28 Pages: 178-188
- DOI
  10.1016/j.mito.2019.08.004
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01170, KAKENHI-PROJECT-17H02094
[Journal Article] Future of human mitochondrial DNA editing technologies2019
- Author(s)
  Verechshagina N, Nikitchina N, Yamada Y, Harashima H, Tanaka M, Orishchenko K, Mazunin I
- Journal Title
  
  Mitochondrial DNA Part A Mapp Seq Anal
  
  Volume: 30 Issue: 2 Pages: 214-221
- DOI
  10.1080/24701394.2018.1472773
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H01872, KAKENHI-PROJECT-17H02094
[Journal Article] ミトコンドリア標的型DDSを基盤とした革新的ナノ医薬品の創製2019
- Author(s)
  山田勇磨
- Journal Title
  
  ファルマシア
  
  Volume: 55 Pages: 330-334
- NAID
  130007621948
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H02094
[Journal Article] ミトコンドリア標的型DDSを基盤とした革新的ナノ医薬品の創製2019
- Author(s)
  山田勇磨
- Journal Title
  
  ファルマシア
  
  Volume: 55 Pages: 330-334
- NAID
  130007621948
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K20076
[Journal Article] Cardiac progenitor cells activated by mitochondrial delivery of resveratrol enhance the survival of a doxorubicin-induced cardiomyopathy mouse model via the mitochondrial activation of a damaged myocardium2018
- Author(s)
  Abe Jiro、Yamada Yuma、Takeda Atsuhito、Harashima Hideyoshi
- Journal Title
  
  J Control Release
  
  Volume: 269 Pages: 177-188
- DOI
  10.1016/j.jconrel.2017.11.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09679
[Journal Article] In Vivo Transgene Expression in the Pancreas by the Intraductal Injection of Naked Plasmid DNA.2018
- Author(s)
  Yamada Y, Tabata M, Abe J, Nomura M, Harashima H.
- Journal Title
  
  J Pharm Sci.
  
  Volume: 107 Issue: 2 Pages: 647-653
- DOI
  10.1016/j.xphs.2017.09.021
- NAID
  120006558999
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11180, KAKENHI-PROJECT-17K09885, KAKENHI-PROJECT-17H02094
[Journal Article] ミトコンドリアへの分子送達技術2018
- Author(s)
  山田勇磨、原島秀吉
- Journal Title
  
  BIO Clinica
  
  Volume: 33 Pages: 637-640
- Data Source
  KAKENHI-PROJECT-17K20076
[Journal Article] Optimization of siRNA delivery to target sites: issues and future directions2018
- Author(s)
  Khalil Ikramy A.、Yamada Yuma、Harashima Hideyoshi
- Journal Title
  
  Expert Opinion on Drug Delivery
  
  Volume: 15 Issue: 11 Pages: 1053-1065
- DOI
  10.1080/17425247.2018.1520836
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H02094
[Journal Article] ミトコンドリアへの分子送達技術2018
- Author(s)
  山田勇磨、原島秀吉
- Journal Title
  
  BIO Clinica
  
  Volume: 33 Pages: 637-640
- Data Source
  KAKENHI-PROJECT-17H02094
[Journal Article] Mitochondrial transgene expression via an artificial mitochondrial DNA vector in cells from a patient with a mitochondrial disease2018
- Author(s)
  Ishikawa Takuya、Somiya Kana、Munechika Reina、Harashima Hideyoshi、Yamada Yuma
- Journal Title
  
  J Control Res
  
  Volume: 274 Pages: 109-117
- DOI
  10.1016/j.jconrel.2018.02.005
- NAID
  120006595504
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H02094
[Journal Article] Innovative technologies in Nanomedicines: from passive targeting to active targeting/from controlled pharmacokinetics to controlled intracellular pharmacokinetics.2017
- Author(s)
  Sato Y, Sakurai Y, Kajimoto K, Nakamura T, Yamada Y, Akita H, Harashima H.
- Journal Title
  
  Macromolecular Bioscience
  
  Volume: 17 Issue: 1 Pages: 1-16
- DOI
  10.1002/mabi.201600179
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26282131, KAKENHI-PROJECT-26282132, KAKENHI-PROJECT-26713002, KAKENHI-PROJECT-26670741, KAKENHI-PROJECT-15K20831, KAKENHI-PROJECT-16K11180
[Journal Article] ミトコンドリアDDS研究のあゆみ：ミトコンドリア標的型ナノカプセル“MITO-Porter”が拓く未来医療2017
- Author(s)
  山田勇磨
- Journal Title
  
  医学のあゆみ
  
  Volume: 260 Pages: 42-48
- Data Source
  KAKENHI-PROJECT-15K12532
[Journal Article] ミトコンドリアを標的とする核酸医薬研究2017
- Author(s)
  山田勇磨
- Journal Title
  
  医学のあゆみ
  
  Volume: 262 Pages: 142-146
- Data Source
  KAKENHI-PROJECT-17H02094
[Journal Article] Mitochondrial Delivery of Doxorubicin Using MITO-Porter Kills Drug-Resistant Renal Cancer Cells via Mitochondrial Toxicity2017
- Author(s)
  Yamada Yuma、Munechika Reina、Kawamura Eriko、Sakurai Yu、Sato Yusuke、Harashima Hideyoshi
- Journal Title
  
  J Pharm Sci
  
  Volume: 106 Issue: 9 Pages: 2428-2437
- DOI
  10.1016/j.xphs.2017.04.058
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K20076, KAKENHI-PROJECT-17H02094
[Journal Article] Validation of the use of an artificial mitochondrial reporter DNA vector containing a Cytomegalovirus promoter for mitochondrial transgene expression.2017
- Author(s)
  Yamada Y, Ishikawa T, Harashima H.
- Journal Title
  
  Biomaterials.
  
  Volume: 136 Pages: 56-66
- DOI
  10.1016/j.biomaterials.2017.05.016
- NAID
  120006716305
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11180, KAKENHI-PROJECT-17H02094
[Journal Article] Packaging of the Coenzyme Q10 into a Liposome for Mitochondrial Delivery and the Intracellular Observation in Patient Derived Mitochondrial Disease Cells2017
- Author(s)
 Yamada Yuma、Burger Laila、Kawamura Eriko、Harashima Hideyoshi
- Journal Title
 
 Biological and Pharmaceutical Bulletin
 
 Volume: 40 Issue: 12 Pages: 2183-2190
- DOI
 10.1248/bpb.b17-00609
- NAID
 130006235437
- ISSN
 0918-6158, 1347-5215
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-17K20076, KAKENHI-PROJECT-17H02094
[Journal Article] Optical control of mitochondrial reductive reactions in living cells using an electron donor?acceptor linked molecule2017
- Author(s)
  Takano Yuta、Munechika Reina、Biju Vasudevanpillai、Harashima Hideyoshi、Imahori Hiroshi、Yamada Yuma
- Journal Title
  
  Nanoscale
  
  Volume: 9 Issue: 47 Pages: 18690-18698
- DOI
  10.1039/c7nr06310e
- NAID
  120006545088
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K20076, KAKENHI-PROJECT-25220801, KAKENHI-PROJECT-17H02094, KAKENHI-PROJECT-15K05563
[Journal Article] ミトコンドリアDDS研究のあゆみ：ミトコンドリア標的型ナノカプセル“MITO-Porter”が拓く未来医療2017
- Author(s)
  山田勇磨
- Journal Title
  
  医学のあゆみ
  
  Volume: 260 Pages: 42-48
- Data Source
  KAKENHI-PROJECT-26282131
[Journal Article] MITO-Porter, Multifunctional Envelope-Type Nano Device for Mitochondrial Delivery toward Innovative Nano Medicine.2017
- Author(s)
  Yamada Y, Harashima H.
- Journal Title
  
  J. Soc. Powder Technol., Japa
  
  Volume: 印刷中
- NAID
  130005606219
- Data Source
  KAKENHI-PROJECT-26282131
[Journal Article] MITO-Porter, Multifunctional Envelope-Type Nano Device for Mitochondrial Delivery toward Innovative Nano Medicine.2017
- Author(s)
  Yamada Y, Harashima H.
- Journal Title
  
  J. Soc. Powder Technol., Japan
  
  Volume: 印刷中
- NAID
  130005606219
- Data Source
  KAKENHI-PROJECT-15K12532
[Journal Article] Validation of a Strategy for Cancer Therapy: Delivering Aminoglycoside Drugs to Mitochondria in HeLa Cells.2016
- Author(s)
  Abe J, Yamada Y, Harashima H.
- Journal Title
  
  Journal of pharmaceutical sciences
  
  Volume: 105 Issue: 2 Pages: 734-740
- DOI
  10.1002/jps.24686
- NAID
  120006581494
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09679, KAKENHI-PROJECT-26670741, KAKENHI-PROJECT-26282131
[Journal Article] A Dual-Ligand Liposomal System Composed of a Cell-Penetrating Peptide and a Mitochondrial RNA Aptamer Synergistically Facilitates Cellular Uptake and Mitochondrial Targeting.2016
- Author(s)
  Yamada Y, Furukawa R, Harashima H.
- Journal Title
  
  J Pharm Sci
  
  Volume: 105 Issue: 5 Pages: 1705-1713
- DOI
  10.1016/j.xphs.2016.03.002
- NAID
  120006220030
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26282131
[Journal Article] Development of a multifunctional envelope-type nano device and its application to nanomedicine.2016
- Author(s)
  Sato Y, Nakamura T, Yamada Y, Harashima H.
- Journal Title
  
  J Control Release
  
  Volume: 244 Pages: 194-204
- DOI
  10.1016/j.jconrel.2016.06.042
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26282131, KAKENHI-PROJECT-26713002, KAKENHI-PROJECT-26670741, KAKENHI-PROJECT-15K20831, KAKENHI-PROJECT-16K11180
[Journal Article] Mitochondrial DDS Opens Innovative Pharmaceutics2016
- Author(s)
  Yuma Yamada
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 136 Issue: 1 Pages: 55-62
- DOI
  10.1248/yakushi.15-00227-3
- NAID
  130005115195
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2016-01-01
- Language
  Japanese
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K12532, KAKENHI-PROJECT-26670741, KAKENHI-PROJECT-26282131
[Journal Article] Targeting the Mitochondrial Genome via a Dual Function MITO-Porter: Evaluation of mtDNA Levels and Mitochondrial Function.2015
- Author(s)
  Yuma Yamada, Hideyoshi Harashima.
- Journal Title
  
  Methods Molecular Biology.
  
  Volume: 1265 Pages: 123-133
- DOI
  10.1007/978-1-4939-2288-8_10
- ISBN
  9781493922871, 9781493922888
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25560219
[Journal Article] Validation of mitochondria gene delivery in liver and skeletal muscle via hydrodynamic injection using an artificial mitochondrial reporter DNA vecto2015
- Author(s)
  Yukari Yasuzaki, Yuma Yamada, Takuya Ishikawa, Hideyoshi Harashima
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume: 12 Issue: 12 Pages: 4311-4320
- DOI
  10.1021/acs.molpharmaceut.5b00511
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K12532, KAKENHI-PROJECT-26282131
[Journal Article] Efficient and high-speed transduction of an antibody into living cells using a multifunctional nano-carrier system to control intracellular trafficking.2015
- Author(s)
  Yuma Yamada, Sandra Milena Vergara Perez, Mai Tabata, Jiro Abe, Yukari Yasuzaki, Hideyoshi Harashima.
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 印刷中 Issue: 9 Pages: 2845-2854
- DOI
  10.1002/jps.24310
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25560219, KAKENHI-PROJECT-26282131
[Journal Article] Mitochondrial DDS has a significant impact on the medical and life sciences: the 7th Young Researcher's Award in the 31th Annual Meeting of the Japan Society of Drug Delivery System.2015
- Author(s)
  山田勇磨
- Journal Title
  
  Drug Delivery System
  
  Volume: 30 Issue: 4 Pages: 348-362
- DOI
  10.2745/dds.30.348
- NAID
  130005116537
- ISSN
  0913-5006, 1881-2732
- Language
  Japanese
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K12532, KAKENHI-PROJECT-26282131
[Journal Article] An analysis of membrane fusion between mitochondrial double membranes and MITO-Porter, mitochondrial fusogenic vesicles2015
- Author(s)
  Yuma Yamada, Yutaka Fukuda, Hideyoshi Harashima
- Journal Title
  
  Mitochondrion
  
  Volume: 24 Pages: 50-55
- DOI
  10.1016/j.mito.2015.07.003
- NAID
  120005828499
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K12532, KAKENHI-PROJECT-26282131
[Journal Article] Hyaluronic acid controls the uptake pathway and intracellular trafficking of an octaarginine modified gene vector in CD44 positive- and CD44 negative-cells.2015
- Author(s)
  Yuma Yamada, Masahiro Hashida, Hideyoshi Harashima.
- Journal Title
  
  Biomaterials
  
  Volume: 52 Pages: 189-198
- DOI
  10.1016/j.biomaterials.2015.02.027
- NAID
  120006313409
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26282131
[Journal Article] Mitochondrial delivery of Coenzyme Q via systemic administration using a MITO-Porter prevents ischemia/reperfusion injury in the mouse liver.2015
- Author(s)
  Yamada Y, Nakamura K, Abe J, Hyodo M, Haga S, Ozaki M, Harashima H.
- Journal Title
  
  Journal of controlled release
  
  Volume: 10 Pages: 86-95
- DOI
  10.1016/j.jconrel.2015.06.037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09679, KAKENHI-PROJECT-26670591, KAKENHI-PROJECT-26830101, KAKENHI-PROJECT-26282131
[Journal Article] Mitochondrial delivery of antisense RNA by MITO-Porter results in mitochondrial RNA knockdown, and has a functional impact on mitochondria2015
- Author(s)
  Ryo Furukawa, Yuma Yamada, Eriko Kawamura, Hideyoshi Harashima
- Journal Title
  
  Biomaterials
  
  Volume: 57 Pages: 107-115
- DOI
  10.1016/j.biomaterials.2015.04.022
- NAID
  120006313408
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K12532, KAKENHI-PROJECT-26282131
[Journal Article] A nanocarrier system for the delivery of nucleic acids targeted to a pancreatic beta cell line.2014
- Author(s)
  Yamada Y, Tabata M, Yasuzaki Y, Nomura M, Shibata A, Ibayashi Y, Taniguchi Y, Sasaki S, Harashima H.
- Journal Title
  
  Biomaterials.
  
  Volume: 印刷中
- NAID
  120005512023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25560219
[Journal Article] Condensation of plasmid DNA enhances mitochondrial delivery targeted to skeletal muscle following hydrodynamic limb vein injection.2014
- Author(s)
  Yukari Yasuzaki, Yuma Yamada, Yutaka Fukuda, Hideyoshi Harashima.
- Journal Title
  
  Pharmaceuticals
  
  Volume: 7 Issue: 8 Pages: 881-893
- DOI
  10.3390/ph7080881
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25560219
[Journal Article] Multifunctional envelope-type nano device for controlled intracellular trafficking and selective targeting in vivo.2014
- Author(s)
  Kazuaki Kajimoto, Yusuke Sato, Takashi Nakamura, Yuma Yamada, Hidesyoshi Harashima.
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 190 Pages: 593-606
- DOI
  10.1016/j.jconrel.2014.03.058
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25560219, KAKENHI-PROJECT-26282131, KAKENHI-PROJECT-26893001
[Journal Article] Mono-cationic detergents play a critical role in the development of liposome-based gene vector via controlling its lamellarity.2014
- Author(s)
  Suzuki R, Yamada Y, Kawamura E, Harashima H.
- Journal Title
  
  Journal of Nanoparticle Research.
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23680053
[Journal Article] A nanocarrier system for the delivery of nucleic acids targeted to a pancreatic beta cell line2014
- Author(s)
  Yamada Y., Tabata M., Yasuzaki Y., Nomura M., Shibata A., Ibayashi Y., Taniguchi Y., Sasaki S., Harashima H.
- Journal Title
  
  Biomaterials
  
  Volume: 35 Issue: 24 Pages: 6430-6438
- DOI
  10.1016/j.biomaterials.2014.04.017
- NAID
  120005512023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229002, KAKENHI-PROJECT-26461383
[Journal Article] RNA Aptamers for Targeting Mitochondria Using a Mitochondria-Based SELEX Method2014
- Author(s)
  Yuri Tawaraya, Mamoru Hyodo, Mst Naznin Ara, Yuma Yamada, Hideyoshi Harashima.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 37 Issue: 8 Pages: 1411-1415
- DOI
  10.1248/bpb.b14-00112
- NAID
  130004677537
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25560219, KAKENHI-PROJECT-26282131
[Journal Article] Development of the MITO-Porter, a Nano Device for Mitochondrial Drug Delivery via Membrane Fusion2014
- Author(s)
 Yuma Yamada
- Journal Title
 
 YAKUGAKU ZASSHI
 
 Volume: 134 Issue: 11 Pages: 1143-1155
- DOI
 10.1248/yakushi.14-00191
- NAID
 130004712974
- ISSN
 0031-6903, 1347-5231
- Year and Date
 2014-11-01
- Language
 Japanese
- Acknowledgement Compliant
- Data Source
 KAKENHI-PROJECT-25560219, KAKENHI-PROJECT-26282131
[Journal Article] Drug Delivery Systems, Mitochondria-Targeted.2014
- Author(s)
  Yamada Y., and Harashima H.
- Journal Title
  
  Encyclopedia of Biomedical Polymers and Polymeric Biomaterials
  
  Volume: 印刷中 Pages: 2883-2893
- DOI
  10.1081/e-ebpp-120050056
- ISBN
  1439898790, 1466501790
- Data Source
  KAKENHI-PROJECT-23680053, KAKENHI-PROJECT-25560219
[Journal Article] A method for screening mitochondrial fusogenic envelopes for use in mitochondrial drug delivery.2014
- Author(s)
  Yamada Y., Harashima H.
- Journal Title
  
  Methods in Molecular Biology.
  
  Volume: 1141 Pages: 57-66
- DOI
  10.1007/978-1-4939-0363-4_2
- ISBN
  9781493903627, 9781493903634
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23680053, KAKENHI-PROJECT-25560219
[Journal Article] p62/SQSTM1 Plays a Protective Role in Oxidative Injury of Steatotic Liver in a Mouse Hepatectomy Model.2014
- Author(s)
  Haga S, Ozawa T, Yamada Y, Morita N, Nagashima I, Inoue H, Inaba Y, Noda N, Abe R, Umezawa K, Ozaki M.
- Journal Title
  
  Antioxid Redox Signal.
  
  Volume: 21 Issue: 18 Pages: 2515-2530
- DOI
  10.1089/ars.2013.5391
- NAID
  120005677747
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25126709, KAKENHI-PROJECT-26282022, KAKENHI-PROJECT-26282131, KAKENHI-PROJECT-26670573, KAKENHI-PROJECT-26670599, KAKENHI-PROJECT-26220805
[Journal Article] Investigation of siRNA nanoparticle formation using mono-cationic detergents and its use in gene silencing in human HeLa cells2013
- Author(s)
  Yamada Y, Suzuki R, Harashima H.
- Journal Title
  
  Cancers (MDPI)
  
  Volume: 5 Issue: 4 Pages: 1413-25
- DOI
  10.3390/cancers5041413
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229002, KAKENHI-PROJECT-23680053, KAKENHI-PROJECT-25560219
[Journal Article] A Lipid Envelop-type Nano Particle Incorporating a Multifunctional Peptide: GALA for the Systemic siRNA Delivery to the Pulmonary Endothelium.2013
- Author(s)
  Kusumoto K, Akita H, Ishitsuka T, Matsumoto Y, Nomoto T, Furukawa R, El-Sayed A, Hatakeyama H, Kajimoto K, Yamada Y, Kataoka K, Harashima H.
- Journal Title
  
  ACS Nano.
  
  Volume: 7 Issue: 9 Pages: 7534-7541
- DOI
  10.1021/nn401317t
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23680053, KAKENHI-PROJECT-23790043
[Journal Article] Intracellular observation of nanocarriers modified with a mitochondrial targeting signal peptide2013
- Author(s)
  Eriko Kawamura, Yuma Yamada, Yukari Yasuzaki, Mamoru Hyodo and Hideyoshi Harashima.
- Journal Title
  
  Journal of bioscience and bioengineering
  
  Volume: 116(5) Issue: 5 Pages: 634-637
- DOI
  10.1016/j.jbiosc.2013.05.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J05438, KAKENHI-PROJECT-21229002, KAKENHI-PROJECT-23680053, KAKENHI-PROJECT-25560219
[Journal Article] Mitochondrial targeting functional peptides as potential devices for the mitochondrial delivery of a DF-MITO-Porter2013
- Author(s)
  Kawamura E, Yamada Y, Harashima H
- Journal Title
  
  Mitochondrion
  
  Volume: 13 Issue: 6 Pages: 610-4
- DOI
  10.1016/j.mito.2013.08.010
- NAID
  120005460249
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23680053, KAKENHI-PROJECT-25560219
[Journal Article] An approach to transgene expression in liver endothelial cells using a liposome-based gene vector coated with hyaluronic acid2013
- Author(s)
  Yamada Y
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23680053
[Journal Article] Enhancement in selective mitochondrial association by direct modification of a mitochondrial targeting signal peptide on a liposomal based nanocarrier.2013
- Author(s)
  Yamada Y, Harashima H.
- Journal Title
  
  Mitochondrion. (Elsevier)
  
  Volume: 13 Issue: 5 Pages: 526-32
- DOI
  10.1016/j.mito.2012.09.001
- NAID
  120005394544
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229002, KAKENHI-PROJECT-23680053
[Journal Article] Localization of exogenous DNA to mitochondria in skeletal muscle following hydrodynamic limb vein injection2013
- Author(s)
  Yukari Yasuzaki, Yuma Yamada, Tsutomu Kanefuji and Hideyoshi Harashima.
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 172(3) Issue: 3 Pages: 805-811
- DOI
  10.1016/j.jconrel.2013.09.029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J05438, KAKENHI-PROJECT-23680053
[Journal Article] Mitochondrial delivery of bongkrekic acid using a MITO-Porter prevents the induction of apoptosis in human HeLa cells.2013
- Author(s)
  Yamada Y, Nakamura K, Furukawa R, Kawamura E, Moriwaki T, Matsumoto K, Okuda K, Shindo M, Harashima H.
- Journal Title
  
  J Pharm Sci.
  
  Volume: 102 Issue: 3 Pages: 1008-1015
- DOI
  10.1002/jps.23442
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J02273, KAKENHI-PROJECT-21229002, KAKENHI-PROJECT-23680053, KAKENHI-PROJECT-24659007, KAKENHI-PUBLICLY-24106731
[Journal Article] A Multifunctional Envelope-type Nanodevice for Use in Nanomedicine: Concept and Applications2012
- Author(s)
  Nakamura T, Akita H, Yamada Y, Hatakeyama H, Harashima H
- Journal Title
  
  Acc Chem Res
  
  Volume: 45(7) Issue: 7 Pages: 1113-1121
- DOI
  10.1021/ar200254s
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229001, KAKENHI-PUBLICLY-24107502
[Journal Article] Targeting Mitochondria: Innovation from Mitochondrial Drug Delivery System (DDS) to Mitochondrial Medicine2012
- Author(s)
  Yamada Y
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 132 Issue: 10 Pages: 1111-1118
- DOI
  10.1248/yakushi.12-00220-4
- NAID
  130001871981
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2012-10-01
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-23680053
[Journal Article] Mitochondrial-targeted DNA delivery using a DF-MITO-Porter, an innovative nano carrier with cytoplasmic and mitochondrial fusogenic envelopes2012
- Author(s)
  Yamada Y
- Journal Title
  
  Journal of Nanoparticle Research
  
  Volume: 14 Issue: 8 Pages: 1013-1013
- DOI
  10.1007/s11051-012-1013-3
- NAID
  120004689034
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23680053
[Journal Article] Multifunctional Envelope-Type Nano Device (MEND) for Organelle Targeting Via a Stepwise Membrane Fusion Process2012
- Author(s)
  Yamada Y
- Journal Title
  
  Methods in Enzymology
  
  Volume: 509 Pages: 301-326
- DOI
  10.1016/b978-0-12-391858-1.00015-0
- ISBN
  9780123918581
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23680053
[Journal Article] The manner in which DNA is packaged with TFAM has an impact on transcription activation and inhibition2012
- Author(s)
  Furukawa R, Yamada Y, Matsushima Y, Goto Y-I, Harashima H.
- Journal Title
  
  FEBS open bio.
  
  Volume: 2 Issue: 1 Pages: 145-150
- DOI
  10.1016/j.fob.2012.06.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J02273, KAKENHI-PROJECT-22229001, KAKENHI-PROJECT-23680053
[Journal Article] Different mechanisms for nanoparticle formation between pDNA and siRNA using Polyrotaxane as the polycation2012
- Author(s)
  Y.Yamada, M.Hashida, T.Nomura, H.Harashima, Y Yamasaki, K.Kataoka, A.Yamashita, R.Katoono, N.Yui
- Journal Title
  
  ChemPhysChem
  
  Volume: 13(5) Issue: 5 Pages: 1161-1165
- DOI
  10.1002/cphc.201100800
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229001, KAKENHI-PLANNED-23107004, KAKENHI-PROJECT-23680053
[Journal Article] Post-nuclear gene delivery events for transgene expression by biocleavable polyrotaxanes2012
- Author(s)
  Y.Yamada, T.Nomura, H.Harashima, A.Yamashita, N.Yui
- Journal Title
  
  Biomaterials
  
  Volume: 33 Issue: 15 Pages: 3952-3958
- DOI
  10.1016/j.biomaterials.2012.01.049
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229001, KAKENHI-PROJECT-23680053, KAKENHI-PLANNED-23107004
[Journal Article] Mitochondria and drug delivery system2012
- Author(s)
  Y.Yamada
- Journal Title
  
  Journal of Pharmaceutical Science and Technology, Japan
  
  Volume: 72 Pages: 53-57
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23680053
[Journal Article] A Multifunctional Envelope-type Nanodevice for Use in Nanomedicine : Concept and Applications2012
- Author(s)
  T.Nakamura, H.Akita, Y.Yamada, H. Hatakeyama, H.Harashima.
- Journal Title
  
  Accounts of Chemical Research
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23680053
[Journal Article] Delivery of bioactive molecules to the mitochondrial genome using a membrane-fusing, liposome-based carrier, DF-MITO-Porter2012
- Author(s)
  Y.Yamada, H.Harashima
- Journal Title
  
  Biomaterials
  
  Volume: 33(5) Issue: 5 Pages: 1589-1595
- DOI
  10.1016/j.biomaterials.2011.10.082
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229001, KAKENHI-PROJECT-23680053
[Journal Article] Mitochondrial Delivery of Bioactive Molecules Using Dual Function MITO-Porter Aimed at the Mitochondrial Genome2012
- Author(s)
  Yamada Y
- Journal Title
  
  CRS Newsletter
  
  Volume: 29 Pages: 15-17
- Data Source
  KAKENHI-PROJECT-23680053
[Journal Article] Dual function MITO-Porter, a nano carrier integrating both efficient cytoplasmic delivery and mitochondrial macromolecule delivery2011
- Author(s)
  Yamada Yuma, Ryo Furukawa, Yukari Yasuzaki, Harashima Hideyoshi
- Journal Title
  
  Molecular Therapy
  
  Volume: 19 Issue: 8 Pages: 1449-1456
- DOI
  10.1038/mt.2011.99
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J02273, KAKENHI-PROJECT-11J05438, KAKENHI-PROJECT-22229001, KAKENHI-PROJECT-23680053
[Journal Article] Octaarginine-modified liposomes enhance the anti-oxidant effect of Lecithinized superoxide dismutase by increasing its cellular uptake.2011
- Author(s)
  R.Furukawa, Y.Yamada, M.Takenaga, R.Igarashi, H.Harashima.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 404
  
  Pages: 796-801
- NAID
  120002834731
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700483
[Journal Article] Octaarginine-modified liposomes enhance the anti-oxidant effect of Lecithinized superoxide dismutase by increasing its cellular uptake.2011
- Author(s)
  古川亮、山田勇磨(First author)、武永美津子、五十嵐理慧、原島秀吉
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 404 Pages: 796-801
- NAID
  120002834731
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700483
[Journal Article] Intranuclear DNA Release is a Determinant of Transfection Activity for a Non-viral vector : Biocleavable Polyrotaxane as a Supramolecularly Dissociative Condenser for Efficient Intranuclear DNA Release.2010
- Author(s)
  Y.Yamada, T.Nomura, H.Harashima, A.Yamashita, R.Katoono, N.Yui.
- Journal Title
  
  Biol.Pharm.Bull. 33
  
  Pages: 1218-1222
- NAID
  130000300290
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700483
[Journal Article] Mitochondrial matrix delivery using a MITO-Porter, a liposome-based carrier that specifies fusion with mitochondrial membranes.2010
- Author(s)
  安崎友香理、山田勇磨(First author)、原島秀吉
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 397 Pages: 181-186
- NAID
  120002834836
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700483
[Journal Article] Transgene expression efficiency from plasmid DNA delivered as a complex with histone H3.2010
- Author(s)
  紙谷浩之、後藤仁美、神田元紀、山田勇磨、原島秀吉
- Journal Title
  
  International Journal of Pharmaceutics
  
  Volume: 392 Pages: 249-253
- NAID
  120002208933
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700483
[Journal Article] Mitochondrial matrix delivery using a MITO-Porter, a liposome-based carrier that specifies fusion with mitochondrial membranes.2010
- Author(s)
  Yukari Yasuzaki, Yuma Yamada, et al
- Journal Title
  
  Biochem.Biophys.Res.Commun.
  
  Volume: 397 Pages: 181-186
- NAID
  120002834836
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22229001
[Journal Article] Mitochondrial matrix delivery using a MITO-Porter, a liposome-based carrier that specifies fusion with mitochondrial membranes.2010
- Author(s)
  Y.Yasuzaki, Y.Yamada, H.Harashima.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 397
  
  Pages: 181-186
- NAID
  120002834836
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700483
[Journal Article] Intranuclear DNA Release is a Determinant of Transfection Activity for a Non-viral vector : Biocleavable Polyrotaxane as a Supramolecularly Dissociative Condenser for Efficient Intranuclear DNA Release.2010
- Author(s)
  山田勇磨、野村卓、原島秀吉、山下敦、上遠野亮、由井伸彦
- Journal Title
  
  Biological & Pharmaceutical Bulletin
  
  Volume: 33 Pages: 1218-1222
- NAID
  130000300290
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700483
[Journal Article] MITO-Porter: a liposome-based carrier system for delivery of macromolecules into mitochondria via membrane fusion.2008
- Author(s)
  山田勇磨
- Journal Title
  
  Biochimica et Biophysica Acta 1778
  
  Pages: 423-432
- NAID
  120000952609
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890001
[Journal Article] Mitochondrialdrug delivery systems formacromolecule and their therapeutic application to mitochondrial diseases2008
- Author(s)
  Y, Yamada, H, Harashima
- Journal Title
  
  Adv, Drug Deliv, Rev 60
  
  Pages: 1439-1462
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890001
[Journal Article] MultifunctionalEnvelope-type Nano Device (MEND) as a non-viral gene delivery system, Adv2008
- Author(s)
  K, Kogure, H, Akita, Y, Yamada, H, Harashima
- Journal Title
  
  Drug Deliv, Rev 60
  
  Pages: 559-571
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890001
[Journal Article] Yamashita, H, Kobayashi, H, Kikuchi, H, Harashima, MITO-Porter : aliposome-based carrier system fordelivery of macromolecules intomitochondria via membrane fusion2008
- Author(s)
  Y, Yamada, H, Akita, H, Kamiya, K, Kogure, T, Yamamoto, Y, Shinohara, K
- Journal Title
  
  Biochimica et Biophysica Acta 1778
  
  Pages: 423-432
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890001
[Journal Article] Mitochondrial drug delivery systems for macromolecule and their therapeutic application to mitochondrial diseases2008
- Author(s)
  山田勇磨
- Journal Title
  
  Advanced Drug Delivery Reviews 60
  
  Pages: 1439-1462
- NAID
  120002989253
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890001
[Journal Article] 多機能性エンベロープ型ナノ構造体による人工遺伝子デリバリーシステムの創製2007
- Author(s)
  原島秀吉, 小暮健太朗, 秋田英万, 山田勇磨, 紙谷浩之
- Journal Title
  
  Drug Delivery System 22
  
  Pages: 569-577
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890001
[Journal Article] 多機能性エンベロープ型人工遺伝子デリバリーシステムの創製2007
- Author(s)
  原島秀吉, 小暮健太朗, 山田勇磨, 秋田英万, 紙谷浩之
- Journal Title
  
  YAKUGAKU ZASSHI 127
  
  Pages: 1655-1672
- NAID
  110006402950
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890001
[Journal Article] Dual Function MITO-Porter, a nano carrier integrating both efficient cytoplasmic delivery and mitochondrial macromolecule delivery.
- Author(s)
  Y.Yamada, R.Furukawa, Y.Yasuzaki, H.Harashima.
- Journal Title
  
  Mol.Ther. (in press)
- NAID
  120003898268
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700483
[Patent] ｃｒＲＮＡ又はガイドＲＮＡ、及びその製造方法2025
- Inventor(s)
  山田勇磨、野呂田楓、佐藤悠介
- Industrial Property Rights Holder
  山田勇磨、野呂田楓、佐藤悠介
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2025-033220
- Filing Date
  2025
- Data Source
  KAKENHI-PROJECT-23H00541
[Patent] ミトコンドリアゲノム編集用脂質ナノ粒子2024
- Inventor(s)
  山田勇磨、原島秀吉、佐藤悠介、渡慶次学、真栄城正寿、他
- Industrial Property Rights Holder
  国立大学法人北海道大学
- Industrial Property Rights Type
  特許
- Filing Date
  2024
- Overseas
- Data Source
  KAKENHI-PROJECT-23H05451
[Patent] ミトコンドリアゲノム編集用脂質ナノ粒子2024
- Inventor(s)
  山田勇磨、原島秀吉、他
- Industrial Property Rights Holder
  山田勇磨、原島秀吉、他
- Industrial Property Rights Type
  特許
- Filing Date
  2024
- Overseas
- Data Source
  KAKENHI-PROJECT-23H00541
[Patent] ミトコンドリアゲノム編集用脂質ナノ粒子2023
- Inventor(s)
  山田勇磨、原島秀吉、他
- Industrial Property Rights Holder
  山田勇磨、原島秀吉、他
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-027872
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-20H04523
[Patent] ミトコンドリアゲノム編集用脂質ナノ粒子2023
- Inventor(s)
  山田勇磨、原島秀吉、佐藤悠介、石塚宣、野呂田楓、ほか
- Industrial Property Rights Holder
  国立大学法人北海道大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-027872
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-19H01170
[Patent] 脂質ナノ粒子2021
- Inventor(s)
  中村孝司、原島秀吉、佐藤悠介、山田小春、中出泰誠
- Industrial Property Rights Holder
  国立大学法人北海道大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-023184
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-19H01170
[Patent] 単離ミトコンドリアを内包した脂質膜ベースの小胞2020
- Inventor(s)
  菅沼正司, 山田勇磨,原島秀吉, 他
- Industrial Property Rights Holder
  菅沼正司, 山田勇磨,原島秀吉, 他
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Overseas
- Data Source
  KAKENHI-PROJECT-20K21872
[Patent] 単離ミトコンドリアの再構成用の凍結乾燥製剤2020
- Inventor(s)
  山田勇磨, 佐々木大輔, 原島秀吉
- Industrial Property Rights Holder
  山田勇磨, 佐々木大輔, 原島秀吉
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-122400
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-20K21872
[Patent] ミトコンドリアＤＮＡの３２４３位のアデニンからグアニンへの変異による変異ｔＲＮＡ　Ｌｅｕを検出する方法2020
- Inventor(s)
  山田勇磨、原島秀吉
- Industrial Property Rights Holder
  北海道大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-073420
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-20H04523
[Patent] ミトコンドリア内でタンパク質を発現させるための核酸、前記核酸を封入した脂質膜構造体及びそれらの利用2019
- Inventor(s)
  原島秀吉, 山田勇磨, 宗宮加奈, 小坂仁
- Industrial Property Rights Holder
  原島秀吉, 山田勇磨, 宗宮加奈, 小坂仁
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-17H02094
[Patent] ミトコンドリアリボソームＲＮＡ変異検出用プライマーＤＮＡセットを含むキット、ミトコンドリアリボソームＲＮＡ発現用核酸、前記核酸を封入してなる脂質膜構造体及びそれらの利用2019
- Inventor(s)
  山田勇磨, 原島秀吉, 丸山美菜子
- Industrial Property Rights Holder
  ルカ・サイエンス
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-089566
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-17H02094
[Patent] ミトコンドリア内でタンパク質を発現させるための核酸、前記核酸を封入した脂質膜構造体及びそれらの利用2018
- Inventor(s)
  原島秀吉、山田勇磨、宗宮加奈、小坂仁
- Industrial Property Rights Holder
  原島秀吉、山田勇磨、宗宮加奈、小坂仁
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-031349
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-17H02094
[Patent] 組換え発現ベクター及び当該ベクターを封入した脂質膜構造体2016
- Inventor(s)
  原島秀吉, 山田勇磨, 石川卓哉, 秋田英万
- Industrial Property Rights Holder
  国立大学法人北海道大学
- Industrial Property Rights Type
  特許
- Filing Date
  2016-11-28
- Overseas
- Data Source
  KAKENHI-PROJECT-26282131
[Patent] 心不全の治療及び／又は予防に用いるための心筋幹細胞2016
- Inventor(s)
  原島秀吉, 山田勇磨, 阿部二郎、武田充人
- Industrial Property Rights Holder
  国立大学法人北海道大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-223069
- Filing Date
  2016-11-16
- Data Source
  KAKENHI-PROJECT-26282131
[Patent] 心不全の治療及び／又は予防に用いるための心筋幹細胞2016
- Inventor(s)
  原島秀吉, 山田勇磨, 阿部二郎、武田充人
- Industrial Property Rights Holder
  国立大学法人北海道大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-223069
- Filing Date
  2016-11-16
- Data Source
  KAKENHI-PROJECT-15K12532
[Patent] 組換え発現ベクター及び当該ベクターを封入した脂質膜構造体2015
- Inventor(s)
  原島秀吉、山田勇磨、石川卓哉、秋田英万
- Industrial Property Rights Holder
  国立大学法人北海道大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-230498
- Filing Date
  2015-11-26
- Data Source
  KAKENHI-PROJECT-26282131
[Patent] 機能性タンパク質を細胞内に送達するためのキャリア2012
- Inventor(s)
  原島秀吉、山田勇磨、サンドラミレーナベルガラペレッツ
- Industrial Property Rights Holder
  国立大学法人北海道大学
- Industrial Property Rights Type
  特許
- Filing Date
  2012-09-19
- Overseas
- Data Source
  KAKENHI-PROJECT-23680053
[Patent] 脂質膜構造体、脂質膜構造体の製造方法および1の目的物質を1枚の脂質膜で封入する方法2012
- Inventor(s)
  原島秀吉、山田勇磨、鈴木亮佑
- Industrial Property Rights Holder
  北海道大学
- Filing Date
  2012-02-24
- Overseas
- Data Source
  KAKENHI-PROJECT-23680053
[Patent] 目的物質をミトコンドリア内に送達可能な脂質膜構造体2012
- Inventor(s)
  山田勇磨、秋田英万、小暮健太朗、紙谷浩之、原島秀吉、菊池寛、小林英夫
- Industrial Property Rights Holder
  国立大学法人北海道大学
- Industrial Property Rights Type
  特許
- Acquisition Date
  2012-08-24
- Overseas
- Data Source
  KAKENHI-PROJECT-23680053
[Patent] 脂質膜構造体、脂質膜構造体の製造方法および1の目的物質を1枚の脂質膜で封入する方法2012
- Inventor(s)
  原島秀吉、山田勇磨、鈴木亮佑
- Industrial Property Rights Holder
  原島秀吉、山田勇磨、鈴木亮佑
- Filing Date
  2012-02-24
- Overseas
- Data Source
  KAKENHI-PROJECT-22229001
[Patent] 機能性タンパク質を細胞内に送達するためのキャリア2012
- Inventor(s)
  原島秀吉、山田勇磨,サンドラミレーナベルガラペレッツ
- Industrial Property Rights Holder
  北海道大学
- Industrial Property Number
  2012-063815
- Filing Date
  2012-03-21
- Data Source
  KAKENHI-PROJECT-23680053
[Patent] 脂質膜構造体、脂質膜構造体の製造方法および1の目的物質を1枚の脂質膜で封入する方法2012
- Inventor(s)
  原島秀吉、山田勇磨、鈴木亮佑
- Industrial Property Rights Holder
  国立大学法人北海道大学
- Industrial Property Rights Type
  特許
- Filing Date
  2012-02-24
- Overseas
- Data Source
  KAKENHI-PROJECT-23680053
[Presentation] Development of mitochondria-targeted nano capsule to transport genome editing devices2025
- Author(s)
  Yuma Yamada
- Organizer
  27th Plant Organelle WS
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-24H02270
[Presentation] 免疫細胞をサブセットレベルで識別する新規標的化技術の開発2024
- Author(s)
  池永季風、島なつみ、松永友美、佐藤悠介、山田勇磨、原島秀吉、中村孝司
- Organizer
  第45回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-23H05451
[Presentation] 臨床応用を目指したコエンザイムQ10搭載ミトコンドリア標的型ナノカプセル製剤の開発2024
- Author(s)
  日比野光恵、廣瀬みさ、真栄城正寿、渡慶次学、山田勇磨
- Organizer
  第40回日本DDS学会
- Data Source
  KAKENHI-ORGANIZER-24H02270
[Presentation] オルガネラ制御を基盤とする細胞操作の実践2024
- Author(s)
  山田勇磨
- Organizer
  日本薬剤学会第39年会
- Invited
- Data Source
  KAKENHI-PROJECT-23H05451
[Presentation] ミトコンドリア標的型 DDS 技術の社会実装を目指して2024
- Author(s)
  山田勇磨
- Organizer
  第29回創剤フォーラム若手研究会
- Invited
- Data Source
  KAKENHI-PROJECT-23K07496
[Presentation] オルガネラ制御を基盤とする細胞操作の実践2024
- Author(s)
  山田勇磨
- Organizer
  日本薬剤学会第39年会（2024年5月23日、神戸国際会議場、神戸）
- Invited
- Data Source
  KAKENHI-PROJECT-23K07496
[Presentation] 遺伝可能なイネ葉緑体ゲノム編集 (C-to-T塩基置換)2024
- Author(s)
  中里一星、山田淳子、堤伸浩、有村慎一
- Organizer
  日本育種学会第146回講演会
- Data Source
  KAKENHI-ORGANIZER-24H02270
[Presentation] ミトコンドリア標的型 DDS 技術の社会実装を目指して2024
- Author(s)
  山田勇磨
- Organizer
  第29回創剤フォーラム若手研究会
- Invited
- Data Source
  KAKENHI-PROJECT-23H00541
[Presentation] オルガネラ制御を基盤とする細胞操作の実践2024
- Author(s)
  山田勇磨
- Organizer
  日本薬剤学会第39年会
- Invited
- Data Source
  KAKENHI-PROJECT-22K19928
[Presentation] 脂質ナノ粒子による肝細胞標的 CRISPR-Cas9 デリバリーの特性評価2024
- Author(s)
  清水りな、小沼はるの、佐藤悠介、原島秀吉、山田勇磨
- Organizer
  日本核酸医薬学会第9回年会
- Data Source
  KAKENHI-ORGANIZER-24H02270
[Presentation] 抗体修飾脂質ナノ粒子によるNK細胞ターゲティング技術の開発2024
- Author(s)
  島なつみ、池永季風、松永友美、佐藤悠介、山田勇磨、原島秀吉、中村孝司
- Organizer
  日本薬学会北海道支部第151回例会
- Data Source
  KAKENHI-PROJECT-23H05451
[Presentation] 新規脂質ライブラリを用いたLNP構造活性相関の解明2024
- Author(s)
  伊藤里奈，山田勇磨，原島秀吉，佐藤悠介
- Organizer
  第45回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-23H05451
[Presentation] オルガネラ標的型DDSが拓く新時代Nano medicine2024
- Author(s)
  山田勇磨
- Organizer
  第40回日本DDS学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23H00541
[Presentation] 細胞サブセットを識別可能な新規標的化技術の開発2024
- Author(s)
  池永季風、松永友美、佐藤悠介、山田勇磨、原島秀吉、中村孝司
- Organizer
  日本薬学会北海道支部第151回例会
- Data Source
  KAKENHI-PROJECT-23H05451
[Presentation] オルガネラ標的型DDSが拓く新時代Nano medicine2024
- Author(s)
  山田勇磨
- Organizer
  第40回日本DDS学会学術集会（2024年7月11日、つくば国際会議場、つくば）
- Invited
- Data Source
  KAKENHI-PROJECT-23K07496
[Presentation] ミトコンドリア標的型 DDS 技術の社会実装を目指して2024
- Author(s)
  山田勇磨
- Organizer
  第29回創剤フォーラム若手研究会
- Invited
- Data Source
  KAKENHI-PROJECT-23H05451
[Presentation] 細胞材料を素材とする創剤研究2024
- Author(s)
  山田勇磨
- Organizer
  日本薬剤学会第39年会
- Data Source
  KAKENHI-ORGANIZER-24H02270
[Presentation] オルガネラ標的型DDSが拓く新時代Nano medicine2024
- Author(s)
  山田勇磨
- Organizer
  第40回日本DDS学会
- Data Source
  KAKENHI-ORGANIZER-24H02270
[Presentation] 細胞サブセットを識別する新規標的化技術の開発2024
- Author(s)
  中村孝司、池永季風、島なつみ、松永友美、佐藤悠介、山田勇磨、原島秀吉
- Organizer
  第40回日本DDS学会
- Data Source
  KAKENHI-ORGANIZER-24H02270
[Presentation] オルガネラ標的型DDSが拓く新時代Nano medicine2024
- Author(s)
  山田勇磨
- Organizer
  第40回日本DDS学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K19928
[Presentation] ミトコンドリア標的型 DDS 技術の社会実装を目指して2024
- Author(s)
  山田勇磨
- Organizer
  第29回創剤フォーラム若手研究会
- Invited
- Data Source
  KAKENHI-PROJECT-22K19928
[Presentation] オルガネラ制御を基盤とする細胞操作の実践2024
- Author(s)
  山田勇磨
- Organizer
  日本薬剤学会第39年会
- Invited
- Data Source
  KAKENHI-PROJECT-23H00541
[Presentation] 細胞サブセットを識別する新規標的化技術の開発2024
- Author(s)
  中村孝司、池永季風、島なつみ、松永友美、佐藤悠介、山田勇磨、原島秀吉
- Organizer
  第40回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-23H05451
[Presentation] 脂質ナノ粒子調製のイロハ2024
- Author(s)
  山田勇磨
- Organizer
  第40回日本DDS学会
- Data Source
  KAKENHI-ORGANIZER-24H02270
[Presentation] オルガネラ標的型DDSが拓く新時代Nano medicine2024
- Author(s)
  山田勇磨
- Organizer
  第40回日本DDS学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23H05451
[Presentation] ミトコンドリアを標的とするゲノム編集技術の創出を目指して2023
- Author(s)
  山田勇磨
- Organizer
  第96回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-23H05451
[Presentation] ミトコンドリアを操るナノテクノロジーの創出を目指して2023
- Author(s)
  山田勇磨
- Organizer
  北海道大学ニコンイメージングセンター　第10回　蛍光イメージング　ミニシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-22K19928
[Presentation] ミトコンドリア標的型ナノ医薬品の創製を目指して2023
- Author(s)
  山田勇磨
- Organizer
  立命館大学創剤・製剤技術研究コンソーシアム2023年度第2回研究会
- Invited
- Data Source
  KAKENHI-PROJECT-23H05451
[Presentation] ミトコンドリアを標的とした癌治療用ナノカプセルの構築2023
- Author(s)
  山田勇磨
- Organizer
  第82回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-23K21067
[Presentation] 癌光治療用ミトコンドリア標的型ナノカプセルの殺細胞効果を高める光感受性物質の探索2023
- Author(s)
  長縄莉奈、髙野勇太、Zhao Hanjun、真栄城正寿、渡慶次学、原島秀吉、山田勇磨
- Organizer
  日本薬学会北海道支部第150回支部例会
- Data Source
  KAKENHI-PROJECT-23K21067
[Presentation] Innovative therapeutic strategy based on mitochondrial drug delivery system2023
- Author(s)
  Yamada Y
- Organizer
  CRIS (Center for Research on Inflammation of the Skin) meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23H05451
[Presentation] Targeting Mitochondria Based on Mitochondrial Drug Delivery Systems (DDS)2023
- Author(s)
  Yamada Y
- Organizer
  14th edition of the World Congress on Targeting Mitochondria 2023
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23H05451
[Presentation] 癌光治療用ミトコンドリア標的型ナノカプセルの殺細胞効果向上を目指した試み2023
- Author(s)
  長縄莉奈、髙野勇太、Zhao Hanjun、真栄城正寿、渡慶次学、原島秀吉、山田勇磨
- Organizer
  第39回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-23K21067
[Presentation] Targeting Mitochondria Based on Mitochondrial Drug Delivery Systems (DDS).2023
- Author(s)
  Yamada Y
- Organizer
  14th edition of the World Congress on Targeting Mitochondria 2023
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23H00541
[Presentation] Innovative therapeutic strategy based on mitochondrial drug delivery system.2023
- Author(s)
  Yamada Y
- Organizer
  CRIS (Center for Research on Inflammation of the Skin) meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23H00541
[Presentation] ミトコンドリアを標的とするゲノム編集技術の創出を目指して2023
- Author(s)
  山田勇磨
- Organizer
  第96回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-23H00541
[Presentation] ミトコンドリア標的型ナノ医薬品の創製を目指して2023
- Author(s)
  山田勇磨
- Organizer
  創剤・製剤技術研究コンソーシアム2023年度第2回研究会
- Invited
- Data Source
  KAKENHI-PROJECT-23H00541
[Presentation] ミトコンドリア標的型ナノDDS技術及びオルガネラ製剤開発に向けた試み2023
- Author(s)
  山田勇磨
- Organizer
  第 27 回薬物動態談話会セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-22K19928
[Presentation] mtDNA 変異モデルマウス細胞におけるゲノム編集装置の活性評価2023
- Author(s)
  1.野呂田楓、石塚宣、廣瀬みさ、真栄城正寿、渡慶次学、原島秀吉、山田勇磨
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20H04523
[Presentation] ミトコンドリアDDSを基盤とした遺伝子細胞治療への挑戦2022
- Author(s)
  山田勇磨、原島秀吉
- Organizer
  第28回日本遺伝子細胞治療学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20H04523
[Presentation] ミトコンドリアDDSを基盤とした遺伝子細胞治療への挑戦2022
- Author(s)
  山田勇磨、原島秀吉
- Organizer
  第28回日本遺伝子細胞治療学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19H01170
[Presentation] ミトコンドリアを標的とする核酸ナノ医薬品の創製を目指して2022
- Author(s)
  山田勇磨
- Organizer
  ゲノム創薬・創発フォーラム第9回シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-20H04523
[Presentation] Validation of therapeutic strategies using mitochondrial drug delivery systems2022
- Author(s)
  Yamada Y, Harashima H
- Organizer
  Joint Symposium of the Faculty of Pharmaceutical Sciences & WPI-ICReDD in Hokkaido University
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19928
[Presentation] ミトコンドリア標的型 DDS を基盤としたナノ医療の創出を目指して2022
- Author(s)
  山田勇磨、原島秀吉
- Organizer
  第43回生体膜と薬物の相互作用シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-22K19928
[Presentation] 治療用rRNA送達によるミトコンドリア遺伝子治療戦略の検証2022
- Author(s)
  山田勇磨、丸山美菜子、原島秀吉
- Organizer
  日本核酸医薬学会第7回年会
- Invited
- Data Source
  KAKENHI-PROJECT-19H01170
[Presentation] ミトコンドリアDDSの夢：ミトコンドリア標的型ナノ医薬品の創出2022
- Author(s)
  山田勇磨
- Organizer
  日本薬剤学会第37年会
- Invited
- Data Source
  KAKENHI-PROJECT-20H04523
[Presentation] マイクロ流体デバイスを用いた癌光治療用ミトコンドリア標的型ナノキャリアの構築2022
- Author(s)
  窪田文佳、山田勇磨、原島秀吉
- Organizer
  医療薬学フォーラム2022
- Invited
- Data Source
  KAKENHI-PROJECT-21K19036
[Presentation] 治療用rRNA送達によるミトコンドリア遺伝子治療戦略の検証2022
- Author(s)
  山田勇磨、丸山美菜子、原島秀吉
- Organizer
  日本核酸医薬学会第7回年会
- Invited
- Data Source
  KAKENHI-PROJECT-20H04523
[Presentation] 膵がん細胞集団の捕食機構を利用した高性能ミトコンドリア標的型光がん治療薬の開発2021
- Author(s)
  髙野勇太、宮武由甲子、山田勇磨、繁富香織
- Organizer
  第7回北大・部局横断シンポジウム
- Data Source
  KAKENHI-PROJECT-23K21067
[Presentation] Mitochondria-activated myocardial progenitor cell (MITO cell) transplantation therapy in a mouse model of ischemia and reperfusion2021
- Author(s)
  Sasaki D, Yamada Y, Abe J, Takeda A, Harashima H
- Organizer
  54th Annual meeting for European Paediatric and Congenital cardiology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21872
[Presentation] Targeting mitochondria: innovation of mitochondrial drug delivery system (DDS) to mitochondrial medicine.2021
- Author(s)
  Yamada Y, Harashima H.
- Organizer
  Mitochondrial Medicine -Therapeutic Development.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01170
[Presentation] 希少疾患の未来について考える患者とともに挑むイノベーション2021
- Author(s)
  山田勇磨
- Organizer
  iPark Frontier Talk
- Invited
- Data Source
  KAKENHI-PROJECT-20H04523
[Presentation] ミトコンドリア機能を操作するDrug Delivery System2021
- Author(s)
  山田勇磨、原島秀吉
- Organizer
  第30回日本バイオイメージング学会
- Invited
- Data Source
  KAKENHI-PROJECT-20K21872
[Presentation] ミトコンドリア運搬用DDS (Trans MIT system)の開発2021
- Author(s)
  山田勇磨、日比野光恵、伊藤百、荒井愛永、佐々木大輔、真栄城正寿、渡慶次学、太田善浩、原島秀吉
- Organizer
  日本薬剤学会第36年会
- Data Source
  KAKENHI-PROJECT-20K21872
[Presentation] ミトコンドリア標的型 Drug Delivery System を基盤とした遺伝子治療戦略の検証2021
- Author(s)
  山田勇磨、原島秀吉
- Organizer
  日本ゲノム編集学会第6回大会
- Invited
- Data Source
  KAKENHI-PROJECT-20H04523
[Presentation] ヒトミトコンドリア強化心筋幹細胞を用いた、急性心不全モデルラットに対する心筋幹細胞移植療法の治療効果の検討2021
- Author(s)
  佐々木大輔、山田勇磨、後藤悠太、白石真大、武田充人、原島秀吉
- Organizer
  日本薬剤学会第36年会
- Data Source
  KAKENHI-PROJECT-20K21872
[Presentation] ミトコンドリア人工共生による細胞機能制御の試み2021
- Author(s)
  山田勇磨、日比野光恵、伊藤百、荒井愛永、佐々木大輔、真栄城正寿、渡慶次学、太田善浩、原島秀吉
- Organizer
  第37回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-20K21872
[Presentation] ミトコンドリアを標的とする遺伝子治療戦略の検証2021
- Author(s)
  山田勇磨、原島秀吉
- Organizer
  第20回日本ミトコンドリア学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-20H04523
[Presentation] マイクロ流体デバイスを用いた癌光治療用ミトコンドリア標的型ナノキャリアの構築2021
- Author(s)
  窪田文佳、山田勇磨、サトリアルディ-、髙野勇太、真栄城正寿、渡慶次学、原島秀吉
- Organizer
  第42回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-23K21067
[Presentation] 膵がん細胞集団の捕食機構を利用した高性能ミトコンドリア標的型光がん治療薬の開発2021
- Author(s)
  髙野勇太、宮武由甲子、山田勇磨、繁富香織
- Organizer
  第7回北大・部局横断シンポジウム
- Data Source
  KAKENHI-PROJECT-21K19036
[Presentation] マイクロ流体デバイスを用いた癌光治療用ミトコンドリア標的型ナノキャリアの構築2021
- Author(s)
  窪田文佳、山田勇磨、サトリアルディ-、髙野勇太、真栄城正寿、渡慶次学、原島秀吉
- Organizer
  第42回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-21K19036
[Presentation] 希少疾患の未来について考える患者とともに挑むイノベーション2021
- Author(s)
  山田勇磨
- Organizer
  iPark Frontier Talk
- Invited
- Data Source
  KAKENHI-PROJECT-20K21872
[Presentation] Targeting mitochondria: innovation of mitochondrial drug delivery system (DDS) to mitochondrial medicine2021
- Author(s)
  Yamada Y, Harashima H
- Organizer
  Mitochondrial Medicine -Therapeutic Development
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H04523
[Presentation] オルガネラ標的型DDSを基盤とした創剤研究の最前線2021
- Author(s)
  山田勇磨
- Organizer
  第72回北日本小児科学会
- Invited
- Data Source
  KAKENHI-PROJECT-20H04523
[Presentation] ミトコンドリア標的型 Drug Delivery System を基盤とした遺伝子治療戦略の検証2021
- Author(s)
  山田勇磨、原島秀吉
- Organizer
  日本ゲノム編集学会第6回大会
- Invited
- Data Source
  KAKENHI-PROJECT-19H01170
[Presentation] Development of Mitochondrial-targeted Nanocarrier for Photodynamic Therapy Using the Microfluidic Device2021
- Author(s)
  窪田文佳、山田勇磨、サトリアルディ-、髙野勇太、真栄城正寿、渡慶次学、原島秀吉
- Organizer
  第15回次世代を担う若手のための医療薬科学シンポジウム
- Data Source
  KAKENHI-PROJECT-23K21067
[Presentation] 低温下での脂質ナノ粒子の免疫細胞表面への結合が引き起こすトランスフェクション活性の消失2021
- Author(s)
  中村孝司、山田小春、佐藤悠介、原島秀吉
- Organizer
  第37回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-19H01170
[Presentation] Development of Mitochondrial-targeted Nanocarrier for Photodynamic Therapy Using the Microfluidic Device2021
- Author(s)
  窪田文佳、山田勇磨、サトリアルディ-、髙野勇太、真栄城正寿、渡慶次学、原島秀吉
- Organizer
  第15回次世代を担う若手のための医療薬科学シンポジウム
- Data Source
  KAKENHI-PROJECT-21K19036
[Presentation] Mito-porter, A Mitochondrial Dds Towards An Innovative Therapy.2020
- Author(s)
  Yamada Y, Harashima H
- Organizer
  2020 Annual Meeting & Exposition of the Controlled Release Society.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H04523
[Presentation] The challenge of developing mitochondrial nano medicine based on MITO-Porter Technology2020
- Author(s)
  Yamada Y, Harashima H.
- Organizer
  JSPCC-AHA 2020
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21872
[Presentation] Nucleic Acid Drugs and Nanomedicine: Multifunctional Envelope-type Nano Device for Nanomedicine2020
- Author(s)
  Hideyoshi Harashima, Yusuke Sato, Takashi Nakamura, Yuma Yamada
- Organizer
  The 79 Annual Meeting of the Japanese Cancer Association.
- Invited
- Data Source
  KAKENHI-PROJECT-19H01170
[Presentation] A Mitochondrial DDS Towards An Innovative Therapy.2020
- Author(s)
  Yamada Y, Harashima H.
- Organizer
  2020 Annual Meeting & Exposition of the Controlled Release Society. “Rising Suns from Japanese Society of Drug Delivery System”
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01170
[Presentation] Mito-porter, Investigation of Drug Delivery System Targeting Mitochondria.2020
- Author(s)
  Yamada Y, Harashima H.
- Organizer
  The 84th annual scinetific meeting of the japanse circulation society
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21872
[Presentation] MITO-Porter, a cutting-edge mitochondrial DDS.2020
- Author(s)
  Yamada Y, Harashima H.
- Organizer
  Pharmaceutical Society of Korea 2020
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01170
[Presentation] MITO-Porter, a cutting-edge mitochondrial DDS.2020
- Author(s)
  Yamada Y, Harashima H
- Organizer
  Pharmaceutical Society of Korea 2020.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H04523
[Presentation] ミトコンドリア標的型ナノ医薬品の創製を目指して2020
- Author(s)
  山田勇磨
- Organizer
  第35回日本小児神経学会北海道地方会
- Invited
- Data Source
  KAKENHI-PROJECT-20H04523
[Presentation] ミトコンドリア標的型ナノ医薬品の創製を目指して2020
- Author(s)
  山田勇磨
- Organizer
  第35回日本小児神経学会北海道地方会
- Invited
- Data Source
  KAKENHI-PROJECT-20K21872
[Presentation] Mitochondrial transgene expression by the mitochondrial delivery of an artificial mitochondrial DNA vector using a MITO-Porter system2019
- Author(s)
  Yamada Y, Ishikawa T, Harashima H
- Organizer
  2019 Annual Meeting & Exposition of the Controlled Release Society
- Data Source
  KAKENHI-PROJECT-17H02094
[Presentation] MITO-Porter therapy to open innovative therapies targeting mitochondria.2019
- Author(s)
  Yamada Yuma
- Organizer
  16th ASMRM & 19th J-mit
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01170
[Presentation] MITO-Porter, liposomal mitochondrial delivery system: Toward Mitochondrial Nanomedicine2019
- Author(s)
  Yamada Y, Harashima H.
- Organizer
  Liposome Research Days 2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01170
[Presentation] MITO-Porter, liposomal mitochondrial delivery system: Toward Mitochondrial Nanomedicine.2019
- Author(s)
  Yamada Y, Harashima H
- Organizer
  Liposome Research Days 2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H02094
[Presentation] Development of ribosomal RNA-loaded nano device for mitochondrial delivery to achieve mitochondrial deafness related gene therapy2019
- Author(s)
  Maruyama M, Yamada Y, Kita T, Kitajiri S, Usami S, Harashima H
- Organizer
  Liposome Research Days 2019
- Data Source
  KAKENHI-PROJECT-17H02094
[Presentation] オートファジー誘導能を有するミトコンドリアDDSの構築およびオートファジー誘導機構の検証2019
- Author(s)
  山田勇磨、大工原伸之輔、西田慶、田村篤志、由井伸彦、原島秀吉
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17K20076
[Presentation] MITO-Porter therapy to open innovative therapies targeting mitochondria.2019
- Author(s)
  Yamada Y
- Organizer
  16th ASMRM & 19th J-mit.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H02094
[Presentation] ミトコンドリアDDSが描くナノ医療の未来予想図～リポ化プロスタグランジン製剤の話題を含めて～2019
- Author(s)
  山田勇磨
- Organizer
  第12回　北海道小児オータムセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-17H02094
[Presentation] Validation of mitochondrial RNA therapy for mitochondrial diseases using Liposome-based nano device2019
- Author(s)
  Somiya K, Yamada Y, Miyauchi A, Osaka H, Harashima H
- Organizer
  Liposome Research Days 2019
- Data Source
  KAKENHI-PROJECT-17H02094
[Presentation] ミトコンドリア標的型ナノＤＤＳを基盤とした遺伝子・細胞治療の実装2019
- Author(s)
  山田勇磨
- Organizer
  第12回　CHEMBIOハイブリッドレクチャー
- Invited
- Data Source
  KAKENHI-PROJECT-17H02094
[Presentation] TCAサイクルを活性化するビタミンB1封入ミトコンドリア標的型DDSの構築2018
- Author(s)
  石丸拓也、山田勇磨、原島秀吉
- Organizer
  第34回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-17K20076
[Presentation] Mitochondrial DDS opens emerging therapies and novel strategy of new drug development for mitochondrial disorders.2018
- Author(s)
  Yamada Y, Harashima H
- Organizer
  KSAP annual convention 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K20076
[Presentation] 膵島ミトコンドリアを標的とした分子送達技術の開発および糖尿病治療への展開2018
- Author(s)
  山田勇磨
- Organizer
  日本薬学会第138年会
- Invited
- Data Source
  KAKENHI-PROJECT-17K20076
[Presentation] ミトコンドリア機能を制御するナノカプセルの構築および疾患治療に向けた試み2018
- Author(s)
  山田勇磨、原島秀吉
- Organizer
  第91回日本生化学大会
- Invited
- Data Source
  KAKENHI-PROJECT-17K20076
[Presentation] Mitochondrial Nano DDS Toward Innovative Medicine and Therapy.2018
- Author(s)
  Yamada Y
- Organizer
  HIGO Program Cutting edge Seminar.
- Invited
- Data Source
  KAKENHI-PROJECT-17H02094
[Presentation] Mitochondrial DDS for Gene & Cell Therapy.2018
- Author(s)
  Yamada Y, Harashima H
- Organizer
  Cadiovascular and Metabolic Week 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H02094
[Presentation] ミトコンドリアを標的とする遺伝子治療用ナノカプセルの創製2018
- Author(s)
  山田勇磨
- Organizer
  日本核酸医薬学会第4回年会
- Invited
- Data Source
  KAKENHI-PROJECT-17H02094
[Presentation] ミトコンドリア機能を制御するナノカプセルの構築および疾患治療に向けた試み2018
- Author(s)
  山田勇磨、原島秀吉
- Organizer
  第91回日本生化学大会
- Invited
- Data Source
  KAKENHI-PROJECT-17H02094
[Presentation] ミトコンドリア標的型DDSを用いたミトコンドリア病に対する遺伝子治療戦略の検証2018
- Author(s)
  宗宮加奈、山田勇磨、宮内彰彦、小坂仁、原島秀吉
- Organizer
  第18回日本ミトコンドリア学会年会
- Data Source
  KAKENHI-PROJECT-17H02094
[Presentation] The MITO-Porter integrates a mitochondrial drug delivery system with a variety of other current scientific concepts with the goal of developing new innovative technologies and medicines.2018
- Author(s)
  Yamada Y, Harashima H
- Organizer
  The 19th RIES-HOKUDAI International Symposium.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H02094
[Presentation] 膵島ミトコンドリアを標的とした分子送達技術の開発および糖尿病治療への展開2018
- Author(s)
  山田勇磨
- Organizer
  日本薬学会第138年会
- Invited
- Data Source
  KAKENHI-PROJECT-17H02094
[Presentation] ミトコンドリアDDSの使い方2018
- Author(s)
  山田勇磨
- Organizer
  第9回フリーラジカルスクール
- Invited
- Data Source
  KAKENHI-PROJECT-17K20076
[Presentation] The MITO-Porter integrates a mitochondrial drug delivery system with a variety of other current scientific concepts with the goal of developing new innovative technologies and medicines.2018
- Author(s)
  Yamada Y, Harashima H
- Organizer
  The 19th RIES-HOKUDAI International Symposium.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K20076
[Presentation] 治療用RNA搭載ミトコンドリア標的型リポソームによる遺伝子治療戦略の検証2018
- Author(s)
  宗宮加奈、山田勇磨、河村恵理子、宮内彰彦、小坂仁、原島秀吉
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17H02094
[Presentation] ミトコンドリア機能を制御するナノカプセルの開発2018
- Author(s)
  山田勇磨
- Organizer
  第6回ミトコンドリア機能研究会
- Invited
- Data Source
  KAKENHI-PROJECT-17K20076
[Presentation] Mitochondrial Nano DDS Toward Innovative Medicine and Therapy.2018
- Author(s)
  Yamada Y
- Organizer
  HIGO Program Cutting edge Seminar.
- Invited
- Data Source
  KAKENHI-PROJECT-17K20076
[Presentation] Mitochondrial DDS opens emerging therapies and novel strategy of new drug development for mitochondrial disorders.2018
- Author(s)
  Yamada Y, Harashima H
- Organizer
  KSAP annual convention 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H02094
[Presentation] ミトコンドリア病の遺伝子改変治療2018
- Author(s)
  山田勇磨
- Organizer
  H29 年度村山班ミトコンドリア病診断・診療マニュアル作成委員拡大合宿
- Invited
- Data Source
  KAKENHI-PROJECT-17H02094
[Presentation] ミトコンドリア機能を制御するナノカプセルの開発2018
- Author(s)
  山田勇磨
- Organizer
  第6回ミトコンドリア機能研究会
- Invited
- Data Source
  KAKENHI-PROJECT-17H02094
[Presentation] エネルギー産生能を亢進するビタミンB1封入ミトコンドリア標的型ナノキャリアの構築2018
- Author(s)
  石丸拓也、山田勇磨、原島秀吉
- Organizer
  日本薬学会北海道支部第145回例会
- Data Source
  KAKENHI-PROJECT-17K20076
[Presentation] ミトコンドリア標的型DDSを基盤としたナノ医療の創出を目指して2018
- Author(s)
  山田勇磨、原島秀吉
- Organizer
  第18回日本ミトコンドリア学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-17H02094
[Presentation] ミトコンドリア標的型DDSを基盤としたナノ医療の創出を目指して2018
- Author(s)
  山田勇磨、原島秀吉
- Organizer
  第18回日本ミトコンドリア学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-17K20076
[Presentation] ミトコンドリアDDSの使い方2018
- Author(s)
  山田勇磨
- Organizer
  第9回フリーラジカルスクール
- Invited
- Data Source
  KAKENHI-PROJECT-17H02094
[Presentation] Photoinduced reductive reaction in mitochondria by electron donor/acceptor linked molecules2018
- Author(s)
  Yuta Takano*,Reina Munechika,Vasudevanpillai Biju,Hideyoshi Harashima,Hiroshi Imahori,Yuma Yamada
- Organizer
  日本化学会第98春季年会
- Data Source
  KAKENHI-PROJECT-15K05563
[Presentation] 遺伝子・細胞治療に用いるミトコンドリアDDS2018
- Author(s)
  山田勇磨、原島秀吉
- Organizer
  第34回日本DDS学会
- Invited
- Data Source
  KAKENHI-PROJECT-17H02094
[Presentation] ND3変異細胞を対象とした治療用mRNA送達によるミトコンドリア遺伝子治療戦略の検証2018
- Author(s)
  宗宮加奈、山田勇磨、河村恵理子、宮内彰彦、小坂仁、原島秀吉
- Organizer
  日本薬学会北海道支部第145回例会
- Data Source
  KAKENHI-PROJECT-17H02094
[Presentation] ミトコンドリアDDSが拓く新しいミトコンドリア病治療戦略2018
- Author(s)
  山田勇磨、原島秀吉
- Organizer
  第60回日本小児神経学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17H02094
[Presentation] VALIDATION OF MITOCHONDRIAL GENE THERAPY BY MITOCHONDRIAL DELIVERY OF THERAPEUTIC NUCLEIC ACIDS2017
- Author(s)
  Yamada Y, Kawamura E, Harashima H
- Organizer
  EUROMIT2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H02094
[Presentation] Cardiac progenitor cells with resveratrol delivered into mitochondria can ameliorate survival of doxorubicin-induced cardiomyopathy mouse via mitochondrial activation of damaged myocardium.2017
- Author(s)
  Abe J, Yamada Y, Takeda A, Harashima H
- Organizer
  European Society of Cardiology Congress 2017
- Data Source
  KAKENHI-PROJECT-15K09679
[Presentation] PIポリアミドによる病因性ミトコンドリアDNA変異関連疾患の治療2017
- Author(s)
  越川信子、渡部隆義、篠崎喜脩、高取敦志、安井七海、リンジェイソン、山田勇磨、原島秀吉、永瀬浩喜
- Organizer
  2017年度生命科学系学会合同年次大会
- Invited
- Data Source
  KAKENHI-PROJECT-17H02094
[Presentation] ミトコンドリアを診る・操る・治すDrug Delivery System2017
- Author(s)
  山田勇磨
- Organizer
  第2回先端ケミカルバイオロジー研究会
- Invited
- Data Source
  KAKENHI-PROJECT-17H02094
[Presentation] ミトコンドリアドラッグデリバリーを用いた幹細胞移植はドキソルビシン心筋症予後を改善する2017
- Author(s)
  阿部　二郎、山田　勇磨、武田　充人、原島　秀吉
- Organizer
  第39回心筋生検研究会
- Data Source
  KAKENHI-PROJECT-15K09679
[Presentation] オートファジー誘導能を有する超分子構造ポリマー搭載 MITO-Porter の構築および機能評価2017
- Author(s)
  大工原伸之輔、山田勇磨、原島秀吉
- Organizer
  日本薬学会北海道支部第144回例会
- Data Source
  KAKENHI-PROJECT-17K20076
[Presentation] An innovative cell therapy using mitochondrial drug delivery system for mitochondrial cardiomyopathy2017
- Author(s)
  Abe J, Yamada Y, Takeda A, Harashima H
- Organizer
  Euro Mit 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09679
[Presentation] 癌細胞ミトコンドリアを標的とした光殺細胞効果の検証2017
- Author(s)
  山田勇磨、高野勇太、宗近玲那、福田豊、今堀博、原島秀吉
- Organizer
  第70回日本酸化ストレス学会学術集会
- Data Source
  KAKENHI-PROJECT-17K20076
[Presentation] ミトコンドリアＤＤＳの開発と医療分野への展開2017
- Author(s)
  山田勇磨
- Organizer
  第11回次世代を担う若手医療薬科学シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17H02094
[Presentation] Validation of cardiac progenitor cell therapy using mitochondrial drug delivery system for doxorubicin-induced cardiomyopathy2017
- Author(s)
  Abe J, Yamada Y, Takeda A, Harashima H
- Organizer
  APSTJ global education seminar
- Data Source
  KAKENHI-PROJECT-15K09679
[Presentation] ミトコンドリア標的型ナノカプセルMITO-Porterを基盤とした遺伝子治療への挑戦2017
- Author(s)
  山田勇磨、原島秀吉
- Organizer
  第59回日本先天代謝異常学会
- Invited
- Data Source
  KAKENHI-PROJECT-17H02094
[Presentation] Validation of mitochondrial gene therapy using a MITO-Porter2017
- Author(s)
  Yamada Y, Harashima H
- Organizer
  8th SFRR-Asia & 14th ASMRM
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H02094
[Presentation] ミトコンドリアDDSを基盤とした遺伝子・細胞治療への展開2017
- Author(s)
  山田勇磨、原島秀吉
- Organizer
  第33回日本DDS学会
- Invited
- Data Source
  KAKENHI-PROJECT-17H02094
[Presentation] 癌細胞ミトコンドリアを標的とした光殺細胞効果の検証2017
- Author(s)
  山田勇磨、高野勇太、宗近玲那、福田豊、今堀博、原島秀吉
- Organizer
  第70回日本酸化ストレス学会学術集会
- Data Source
  KAKENHI-PROJECT-17H02094
[Presentation] ドキソルビシン心筋症に対するミトコンドリアドラッグデリバリーシステムを用いた心筋前駆細胞移植の検討2017
- Author(s)
  阿部　二郎, 山田　勇磨, 武田　充人, 原島　秀吉
- Organizer
  第53回日本小児循環器学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-15K09679
[Presentation] ミトコンドリアを診る・操る・治すDrug Delivery System2017
- Author(s)
  山田勇磨
- Organizer
  第2回先端ケミカルバイオロジー研究会
- Invited
- Data Source
  KAKENHI-PROJECT-17K20076
[Presentation] Nano-drug delivery system for mitochondrial gene therapy2017
- Author(s)
  Yamada Y, Harashima H
- Organizer
  The 18th International Union of Materials Research Societies, International Conference in Asia (IUMRS-ICA) 2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H02094
[Presentation] Validation of autophagy induction via the mitochondrial delivery of Polyrotaxane by a MITO-Porter2017
- Author(s)
  Daikuhara S, Yamada Y, Tamura A, Nishida K, Yui N, Harashima H.
- Organizer
  The 2nd International Symposium on Biomedical Engineering
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K20076
[Presentation] ミトコンドリアマトリクス環境応答性を有する核酸ナノ粒子の設計2017
- Author(s)
  山田勇磨、福田豊、原島秀吉
- Organizer
  日本核酸医薬学会第3回年会
- Data Source
  KAKENHI-PROJECT-17H02094
[Presentation] Fullerene-porphyrin-ferrocene linked molecule for optically-controlled intracellular electron transfer in mitochondria for targeted cancer cell death2017
- Author(s)
  高野勇太*,宗近玲那,Vasudevanpillai Biju,原島秀吉,山田勇磨,今堀博
- Organizer
  第53回フラーレン・ナノチューブ・グラフェン総合シンポジウム
- Data Source
  KAKENHI-PROJECT-15K05563
[Presentation] オートファジー誘導能を有する超分子構造ポリマー搭載ミトコンドリアDDSの構築2017
- Author(s)
  大工原伸之輔、山田勇磨、田村篤志、西田慶、由井伸彦、原島秀吉
- Organizer
  第33回日本DDS学会
- Data Source
  KAKENHI-PROJECT-17K20076
[Presentation] ミトコンドリア外来遺伝子発現を可能とするDDSの開発2017
- Author(s)
  山田勇磨、石川卓哉、原島秀吉
- Organizer
  日本薬剤学会第32年会
- Data Source
  KAKENHI-PROJECT-17H02094
[Presentation] 光誘起電荷分離分子からの電子移動反応を利用した癌細胞ミトコンドリア内での光還元反応手法の開発2017
- Author(s)
  高野勇太*,宗近玲那,福田豊,Vasudevanpillai Biju,今堀博,原島秀吉,山田勇磨
- Organizer
  2017年光化学討論会
- Data Source
  KAKENHI-PROJECT-15K05563
[Presentation] ミトコンドリアＤＤＳの開発と医療分野への展開2017
- Author(s)
  山田勇磨
- Organizer
  第11回次世代を担う若手医療薬科学シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17K20076
[Presentation] 癌細胞ミトコンドリアを標的とした光殺細胞効果の検証2017
- Author(s)
  山田勇磨*,高野勇太,宗近玲那,福田豊,今堀博,原島秀吉
- Organizer
  第70回日本酸化ストレス学会学術集会
- Data Source
  KAKENHI-PROJECT-15K05563
[Presentation] ミトコンドリア薬物送達システムを用いた心筋炎に対する新たな治療戦略2016
- Author(s)
  阿部　二郎、山田　勇磨、武田　充人、原島　秀吉
- Organizer
  日本小児循環器学会学術集会
- Place of Presentation
  東京ドームホテル（東京都文京区）
- Data Source
  KAKENHI-PROJECT-15K09679
[Presentation] 癌細胞ミトコンドリアを標的としたアミノグリコシド系薬剤を用いた新規治療戦略の検証2016
- Author(s)
  阿部二郎、山田勇磨、原島秀吉
- Organizer
  第75回日本癌学会総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-26670741
[Presentation] Validation of an innovative cancer therapy for targeting mitochondria in cancer cells using aminoglycoside drugs2016
- Author(s)
  Jiro Abe, Yuma Yamada, Hideyoshi Harashima
- Organizer
  日本癌学会総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Data Source
  KAKENHI-PROJECT-15K09679
[Presentation] ミトコンドリア標的型ナノカプセル・MITO-Porterの開発とナノバイオ研究への展開2016
- Author(s)
  山田勇磨、原島秀吉
- Organizer
  第五回ナノカーボンバイオシンポジウム
- Place of Presentation
  北海道立道民活動センターかでる2.7 (北海道・札幌市)
- Data Source
  KAKENHI-PROJECT-15K12532
[Presentation] ミトコンドリア標的型ナノカプセル・MITO-Porterを用いたミトコンドリアを標的とする疾患治療戦略の提案2016
- Author(s)
  山田勇磨、原島秀吉
- Organizer
  第10回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  群馬大学昭和キャンパス（群馬県・前橋市）
- Data Source
  KAKENHI-PROJECT-15K12532
[Presentation] ミトコンドリア移行性RNAアプタマー搭載Dual-ligandリポソームの構築および細胞導入・ミトコンドリア移行の検証2016
- Author(s)
  山田勇磨、古川亮、原島秀吉
- Organizer
  第32回日本DDS学会学術集会
- Place of Presentation
  グランシップ(静岡県・静岡市)
- Data Source
  KAKENHI-PROJECT-26282131
[Presentation] ミトコンドリア標的型ナノカプセル・MITO-Porterの開発とナノバイオ研究への展開2016
- Author(s)
  山田勇磨、原島秀吉
- Organizer
  第五回ナノカーボンバイオシンポジウム
- Place of Presentation
  北海道立道民活動センターかでる2.7 (北海道・札幌市)
- Data Source
  KAKENHI-PROJECT-26282131
[Presentation] ミトコンドリア薬物送達システムを用いた心筋炎に対する新たな治療戦略2016
- Author(s)
  阿部二郎、山田勇磨、武田充人、原島秀吉
- Organizer
  第52回日本小児循環器学会総会・学術集会
- Place of Presentation
  東京ドームホテル (東京都・文京区)
- Data Source
  KAKENHI-PROJECT-15K12532
[Presentation] ミトコンドリア標的型インテリジェントナノデバイスを用いた遺伝子治療への挑戦2016
- Author(s)
  山田勇磨、原島秀吉
- Organizer
  第25回インテリジェント材料・システムシンポジウム
- Place of Presentation
  東京女子医科大学　先端生命医科学研究所 TWIns（東京都新宿区）
- Year and Date
  2016-01-08
- Data Source
  KAKENHI-PROJECT-15K12532
[Presentation] ミトコンドリア標的型インテリジェントナノデバイスを用いた遺伝子治療への挑戦2016
- Author(s)
  山田勇磨、原島秀吉
- Organizer
  第25回インテリジェント材料・システムシンポジウム
- Place of Presentation
  東京女子医科大学　先端生命医科学研究所 TWIns（東京都新宿区）
- Year and Date
  2016-01-08
- Data Source
  KAKENHI-PROJECT-26282131
[Presentation] ミトコンドリアDDS (Drug Delivery System) が拓く医療の未来2016
- Author(s)
  阿部二郎、山田勇磨、武田充人、原島秀吉
- Organizer
  北海道大学医学部・小児科・オータムセミナー2016
- Place of Presentation
  ネストホテル札幌駅前 (北海道・札幌市)
- Invited
- Data Source
  KAKENHI-PROJECT-15K12532
[Presentation] ミトコンドリア標的型ナノカプセル・MITO-Porterを用いたミトコンドリアを標的とする疾患治療戦略の提案2016
- Author(s)
  山田勇磨、原島秀吉
- Organizer
  第10回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  群馬大学昭和キャンパス(群馬県・前橋市)
- Data Source
  KAKENHI-PROJECT-26282131
[Presentation] ミトコンドリアDDS (Drug Delivery System) が拓く医療の未来2016
- Author(s)
  阿部二郎、山田勇磨、武田充人、原島秀吉
- Organizer
  北海道大学医学部・小児科・オータムセミナー2016
- Place of Presentation
  ネストホテル札幌駅前
- Data Source
  KAKENHI-PROJECT-26670741
[Presentation] ミトコンドリアDDS (Drug Delivery System) が拓く医療の未来2016
- Author(s)
  阿部二郎、山田勇磨、武田充人、原島秀吉
- Organizer
  北海道大学医学部・小児科・オータムセミナー2016
- Place of Presentation
  ネストホテル札幌駅前 (北海道・札幌市)
- Invited
- Data Source
  KAKENHI-PROJECT-26282131
[Presentation] ドキソルビシン封入ミトコンドリア標的型リポソームを用いた耐性癌治療戦略の検証2016
- Author(s)
  宗近玲那、山田勇磨、河村恵理子、櫻井遊、佐藤悠介、原島秀吉
- Organizer
  日本薬剤学会第31年会
- Place of Presentation
  長良川国際会議場（岐阜県・岐阜市）
- Data Source
  KAKENHI-PROJECT-15K12532
[Presentation] Innovative strategy to manage myocarditis using mitochondrial drug delivery system(DDS)2016
- Author(s)
  Jiro Abe, Yuma Yamada, Atuhito Takeda, Hideyoshi Harashima
- Organizer
  Congress of The Asia-Pacific Pediatric Cardiac Society, APPCS-AEPC Joint Session
- Place of Presentation
  Shanghai (China)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09679
[Presentation] ミトコンドリアDDSの創製と心疾患治療への展開2016
- Author(s)
  山田勇磨
- Organizer
  第3回iHFフォーラム
- Place of Presentation
  ホテルオークラ東京（東京都・港区）
- Invited
- Data Source
  KAKENHI-PROJECT-15K12532
[Presentation] Mitochondria: Innovative strategy to manage myocarditis using mitochondrial drug delivery system (DDS).2016
- Author(s)
  Abe J, Yamada Y, Takeda A, Harashima H.
- Organizer
  Asia-Pacific Pediatric Cardiology Society 6th Congress.
- Place of Presentation
  Shanghai (China)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26282131
[Presentation] ミトコンドリア薬物送達システムを用いた心筋炎に対する新たな治療戦略2016
- Author(s)
  阿部二郎、山田勇磨、武田充人、原島秀吉
- Organizer
  第52回日本小児循環器学会総会・学術集会
- Place of Presentation
  東京ドームホテル (東京都・文京区)
- Data Source
  KAKENHI-PROJECT-26282131
[Presentation] 癌細胞ミトコンドリアを標的としたアミノグリコシド系薬剤を用いた新規治療戦略の検証2016
- Author(s)
  阿部二郎、山田勇磨、原島秀吉
- Organizer
  第75回日本癌学会総会
- Place of Presentation
  パシフィコ横浜(神奈川県・横浜市)
- Data Source
  KAKENHI-PROJECT-26282131
[Presentation] ミトコンドリア標的型ナノカプセル・MITO-Porterを用いたミトコンドリアを標的とする疾患治療戦略の提案2016
- Author(s)
  山田勇磨、原島秀吉
- Organizer
  第10回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  群馬大学昭和キャンパス
- Invited
- Data Source
  KAKENHI-PROJECT-26670741
[Presentation] ミトコンドリアを標的とするDDSを用いた薬剤耐性癌治療戦略の検証2016
- Author(s)
  山田勇磨、原島秀吉
- Organizer
  第75回日本癌学会総会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Data Source
  KAKENHI-PROJECT-15K12532
[Presentation] Mitochondria: Innovative strategy to manage myocarditis using mitochondrial drug delivery system (DDS).2016
- Author(s)
  Abe J, Yamada Y, Takeda A, Harashima H.
- Organizer
  Asia-Pacific Pediatric Cardiology Society 6th Congress.
- Place of Presentation
  Shanghai (China)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K12532
[Presentation] ミトコンドリアDDSの創製と心疾患治療への展開2016
- Author(s)
  山田勇磨
- Organizer
  第3回iHFフォーラム
- Place of Presentation
  ホテルオークラ東京（東京都・港区）
- Invited
- Data Source
  KAKENHI-PROJECT-26282131
[Presentation] CoenzymeQ10搭載ミトコンドリア標的型ナノカプセルの構築および肝虚血再灌流障害誘発モデルマウスを用いた治療戦略の検証2016
- Author(s)
  山田勇磨、中村宏平、原島秀吉
- Organizer
  第69回日本酸化ストレス学会学術集会
- Place of Presentation
  仙台国際センター(宮城県・仙台市)
- Data Source
  KAKENHI-PROJECT-26282131
[Presentation] 周産期死亡した先天性心疾患胎児診断症例2016
- Author(s)
  佐々木理、武田充人、谷口宏太、泉岳、山澤弘州、山田崇弘、水上尚典
- Organizer
  日本小児循環器学会学術集会
- Place of Presentation
  東京ドームホテル（東京都文京区）
- Data Source
  KAKENHI-PROJECT-15K09679
[Presentation] MITO-Porter, mitochondrial drug delivery system toward innovative therapy2015
- Author(s)
  Yuma Yamada, Hideyoshi Harashima
- Organizer
  DRUG DELIVERY 2015, World Drug Delivery Summit
- Place of Presentation
  Houston (USA)
- Year and Date
  2015-08-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K12532
[Presentation] ミトコンドリアを科学するナノデバイス MITO-Porter の創製2015
- Author(s)
  山田勇磨、原島秀吉
- Organizer
  日本薬学会第135年会.　一般シンポジウムS46-5
- Place of Presentation
  神戸学院大学（兵庫県）
- Year and Date
  2015-03-27
- Invited
- Data Source
  KAKENHI-PROJECT-25560219
[Presentation] 癌細胞ミトコンドリアを標的としたアミノグリコシド系薬剤による癌治療戦略の検証2015
- Author(s)
  阿部二郎、山田勇磨、原島秀吉
- Organizer
  第15回日本ミトコンドリア学会
- Place of Presentation
  福井県国際交流会館（福井県福井市）
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-26282131
[Presentation] ミトコンドリア標的型核酸ナノキャリアの開発および核酸医薬への展開2015
- Author(s)
  山田勇磨、河村恵理子、古川亮、原島秀吉
- Organizer
  日本核酸医薬学会　第1回年会
- Place of Presentation
  京都テルサ（京都府京都市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K12532
[Presentation] Targeted mitochondrial delivery of functional nucleic acids using MITO-Porter2015
- Author(s)
  Eriko Kawamura, Yuma Yamada, Harashima Harashim
- Organizer
  42nd Annual Meeting & Exposition of the Controlled Release Society
- Place of Presentation
  Edinburgh（Scotland, UK)
- Year and Date
  2015-07-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26282131
[Presentation] ミトコンドリア DDS が拓く新しい薬剤学2015
- Author(s)
  山田勇磨
- Organizer
  日本薬学会第135年会.　一般シンポジウムS08-3
- Place of Presentation
  神戸学院大学（兵庫県）
- Year and Date
  2015-03-26
- Invited
- Data Source
  KAKENHI-PROJECT-26282131
[Presentation] 癌細胞ミトコンドリアを標的としたアミノグリコシド系薬剤による癌治療戦略の検証2015
- Author(s)
  阿部　二郎, 山田　勇磨, 原島　秀吉
- Organizer
  第15回日本ミトコンドリア学会年会
- Place of Presentation
  福井県国際交流会館（福井県福井市）
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-15K09679
[Presentation] MITO-Porter, mitochondrial drug delivery system toward innovative therapy2015
- Author(s)
  Yuma Yamada, Harashima Harashima
- Organizer
  DRUG DELIVERY 2015, World Drug Delivery Summit
- Place of Presentation
  Houston (USA)
- Year and Date
  2015-08-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26282131
[Presentation] アミノグリコシド系薬剤による癌細胞内ミトコンドリアを標的とした殺細胞効果の検証2015
- Author(s)
  阿部二郎、山田勇磨、原島秀吉
- Organizer
  24回日本Cell Death学会
- Place of Presentation
  大阪大学会館（大阪市豊中市）
- Year and Date
  2015-07-11
- Data Source
  KAKENHI-PROJECT-26282131
[Presentation] ミトコンドリア標的型ナノマシン“MITO-Porter”の開発2015
- Author(s)
  山田勇磨、原島秀吉
- Organizer
  第24回日本Cell Death学会　シンポジウム１
- Place of Presentation
  大阪大学会館（大阪府豊中市）
- Year and Date
  2015-07-11
- Invited
- Data Source
  KAKENHI-PROJECT-15K12532
[Presentation] CoenzymeQ10搭載MITO-Porterの構築およびin vivoミトコンドリア送達・疾患治療戦略の検証2015
- Author(s)
  山田勇磨、中村宏平、原島秀吉
- Organizer
  日本薬剤学会第30年会
- Place of Presentation
  長崎ブリックホール（長崎県長崎市）
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-26282131
[Presentation] Targeted mitochondrial delivery of functional nucleic acids using MITO-Porter2015
- Author(s)
  Eriko Kawamura, Yuma Yamada, Harashima Harashima
- Organizer
  42nd Annual Meeting & Exposition of the Controlled Release Society
- Place of Presentation
  Edinburgh （Scotland, UK)
- Year and Date
  2015-07-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K12532
[Presentation] ミトコンドリア遺伝子発現DNAベクターの設計および遺伝子発現評価2015
- Author(s)
  石川卓哉、山田勇磨、原島秀吉
- Organizer
  日本核酸医薬学会　第1回年会
- Place of Presentation
  京都テルサ（京都府京都市）
- Year and Date
  2015-11-30
- Data Source
  KAKENHI-PROJECT-15K12532
[Presentation] ミトコンドリア標的型DDS、MITO-Porterを用いた機能性核酸送達および機能評価2015
- Author(s)
  河村恵理子、山田勇磨、古川亮、原島秀吉
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学院大学（兵庫県）
- Year and Date
  2015-03-28
- Data Source
  KAKENHI-PROJECT-26282131
[Presentation] MITO-Porter, an innovative technology for mitochondrial drug delivery2015
- Author(s)
  Yuma Yamada
- Organizer
  The 1st HU-TMU-KU Joint Symposium for Pharm. Sci.
- Place of Presentation
  北海道大学 (北海道札幌市)
- Year and Date
  2015-08-29
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26282131
[Presentation] ミトコンドリアDDSが拓く医療・ライフサイエンス革命2015
- Author(s)
  山田勇磨
- Organizer
  第31回日本DDS学会. 第7回奨励賞受賞講演
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2015-07-03
- Invited
- Data Source
  KAKENHI-PROJECT-26282131
[Presentation] ゲンタマイシン搭載ミトコンドリア標的型DDSを用いたがん治療戦略の検証2015
- Author(s)
  山田勇磨、阿部二郎、原島秀吉
- Organizer
  第37回日本バイオマテリアル学会大会
- Place of Presentation
  京都テルサ（京都府京都市）
- Year and Date
  2015-11-09
- Data Source
  KAKENHI-PROJECT-26282131
[Presentation] ミトコンドリアDDSが拓く医療・ライフサイエンス革命2015
- Author(s)
  山田勇磨
- Organizer
  第31回日本DDS学会. 第7回奨励賞受賞講演
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2015-07-03
- Invited
- Data Source
  KAKENHI-PROJECT-15K12532
[Presentation] アミノグリコシド系薬剤による癌細胞ミトコンドリアを標的とした癌治療戦略の検証2015
- Author(s)
  阿部二郎、山田勇磨、原島秀吉
- Organizer
  日本薬剤学会第30年会
- Place of Presentation
  長崎ブリックホール（長崎県長崎市）
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-26282131
[Presentation] アミノグリコシド系薬剤による癌細胞ミトコンドリアを標的とした癌治療戦略の検証2015
- Author(s)
  阿部　二郎, 山田　勇磨, 原島　秀吉
- Organizer
  日本薬剤学会第30回総会
- Place of Presentation
  長崎ブリックホール（長崎県長崎市）
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-15K09679
[Presentation] ミトコンドリア遺伝子発現DNAベクターの設計および遺伝子発現評価2015
- Author(s)
  石川卓哉、山田勇磨、原島秀吉
- Organizer
  日本核酸医薬学会　第1回年会
- Place of Presentation
  京都テルサ（京都府京都市）
- Year and Date
  2015-11-30
- Data Source
  KAKENHI-PROJECT-26282131
[Presentation] ミトコンドリア標的型ナノマシン“MITO-Porter”の開発2015
- Author(s)
  山田勇磨、原島秀吉
- Organizer
  第24回日本Cell Death学会　シンポジウム１
- Place of Presentation
  大阪大学会館（大阪市豊中市）
- Year and Date
  2015-07-11
- Invited
- Data Source
  KAKENHI-PROJECT-26282131
[Presentation] ミトコンドリア環境応答性核酸ナノ粒子の設計及びその評価2015
- Author(s)
  福田豊、山田勇磨、原島秀吉
- Organizer
  日本核酸医薬学会　第1回年会
- Place of Presentation
  京都テルサ（京都府京都市）
- Year and Date
  2015-11-30
- Data Source
  KAKENHI-PROJECT-15K12532
[Presentation] In vivo mitochondrial delivery of coenzyme Q10 via MITO-Porter prevents ischemic reperfusion injury in the liver2015
- Author(s)
  Yuma Yamada, Kohei Nakamura, Harashima Harashima
- Organizer
  42nd Annual Meeting & Exposition of the Controlled Release Society
- Place of Presentation
  Edinburgh（Scotland, UK)
- Year and Date
  2015-07-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26282131
[Presentation] アミノグリコシド系薬剤による癌細胞内ミトコンドリアを標的とした殺細胞効果の検証2015
- Author(s)
  阿部　二郎, 山田　勇磨, 原島　秀吉
- Organizer
  第２４回日本Cell Death学会学術集会
- Place of Presentation
  大阪大学会館（大阪府吹田市）
- Year and Date
  2015-07-11
- Data Source
  KAKENHI-PROJECT-15K09679
[Presentation] MITO-Porter, an innovative technology for mitochondrial drug delivery2015
- Author(s)
  Yuma Yamada
- Organizer
  The 1st HU-TMU-KU Joint Symposium for Pharm. Sci.
- Place of Presentation
  北海道大学（北海道札幌市）
- Year and Date
  2015-08-29
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K12532
[Presentation] Targeted delivery of nucleic acids using mitochondrial delivery system and regulation of the mitochondrial function2014
- Author(s)
  E. Kawamura, Y. Yamada, R. Furukawa, H. Harashima
- Organizer
  The 17th Hokkaido University-Seoul National University Joint Symposium
- Place of Presentation
  Hokkaido Univ. (Sapporo)
- Year and Date
  2014-11-28
- Data Source
  KAKENHI-PROJECT-26282131
[Presentation] ミトコンドリア（Mt）膜融合能特性の解析およびMt二層膜構造を突破する核酸送達システムの開発2014
- Author(s)
  福田豊、山田勇磨、原島秀吉
- Organizer
  第30回日本DDS学会
- Place of Presentation
  東京. (慶応義塾大学)
- Year and Date
  2014-07-31
- Data Source
  KAKENHI-PROJECT-25560219
[Presentation] MITO-Porter, Liposome-Based Nano Device for Mitochondrial Control2014
- Author(s)
  Y. Yamada.
- Organizer
  iCeMS-RIKEN Joint Symposium on Mesoscopic Chemical Biology
- Place of Presentation
  iCeMS Main Building (Japan)
- Invited
- Data Source
  KAKENHI-PROJECT-23680053
[Presentation] MITO-Porter: Membrane-type nano device for mitochondrial drug delivery via membrane fusion2014
- Author(s)
  Hideyoshi Harashima and Yuma Yamada
- Organizer
  Euromit 2014
- Place of Presentation
  Tampere Hall (Finland)
- Year and Date
  2014-06-19
- Invited
- Data Source
  KAKENHI-PROJECT-25560219
[Presentation] "ミトコンドリア標的型ナノデバイス"MITO-Porter"の創製2014
- Author(s)
  山田勇磨
- Organizer
  日本薬学会第134年会奨励賞受賞講演
- Place of Presentation
  ホテル日航熊本(熊本)
- Year and Date
  2014-03-28
- Data Source
  KAKENHI-PROJECT-23680053
[Presentation] ミトコンドリア標的型核酸ナノキャリアの開発と今後の展開2014
- Author(s)
  山田勇磨
- Organizer
  第30回日本DDS学会. 特別シンポジウムⅡ
- Place of Presentation
  慶應義塾大学（東京都）
- Year and Date
  2014-07-31
- Invited
- Data Source
  KAKENHI-PROJECT-26282131
[Presentation] MITO-Porter, a mitochondrial drug delivery system toward innovative medicine and therapy.2014
- Author(s)
  Y. Yamada.
- Organizer
  2nd CRED Symposium for Academic Drug Discovery.
- Place of Presentation
  Hokkaido Univ. (Japan)
- Invited
- Data Source
  KAKENHI-PROJECT-23680053
[Presentation] ミトコンドリアを標的とするDrug Delivery Systemの開発2014
- Author(s)
  山田勇磨
- Organizer
  日本薬剤学会第29年会奨励賞受賞講演
- Place of Presentation
  大宮ソニックシティビル（埼玉県）
- Year and Date
  2014-05-21
- Invited
- Data Source
  KAKENHI-PROJECT-26282131
[Presentation] ミトコンドリア標的型ナノデバイス”MITO-Porter”の創製2014
- Author(s)
  山田勇磨
- Organizer
  日本薬学会第134年会奨励賞受賞講演
- Place of Presentation
  ホテル日航熊本 (熊本県)
- Invited
- Data Source
  KAKENHI-PROJECT-25560219
[Presentation] ミトコンドリア標的型核酸ナノキャリアの開発と今後の展開2014
- Author(s)
  山田勇磨
- Organizer
  第30回日本DDS学会. 特別シンポジウムⅡ
- Place of Presentation
  慶應義塾大学（東京都）
- Year and Date
  2014-07-31
- Invited
- Data Source
  KAKENHI-PROJECT-25560219
[Presentation] MITO-Porter, Liposome-Based Nano Device for Mitochondrial Control2014
- Author(s)
  Y. Yamada
- Organizer
  iCeMS-RIKEN Joint Symposium on Mesoscopic Chemical Biology
- Place of Presentation
  iCeMS main buildig (Japan).
- Year and Date
  2014-02-07
- Data Source
  KAKENHI-PROJECT-23680053
[Presentation] ミトコンドリアを標的とするDrug Delivery Systemの開発2014
- Author(s)
  山田勇磨
- Organizer
  日本薬剤学会第29年会奨励賞受賞講演
- Place of Presentation
  大宮ソニックシティビル（埼玉県）
- Year and Date
  2014-05-21
- Invited
- Data Source
  KAKENHI-PROJECT-25560219
[Presentation] ミトコンドリア(Mt)膜融合性特性の解析およびMtマトリクス標的型キャリアの開発.2014
- Author(s)
  福田豊、山田勇磨、原島秀吉
- Organizer
  日本薬学会北海道支部第141回例会
- Place of Presentation
  札幌(札幌コンベンションセンター)
- Year and Date
  2014-05-24
- Data Source
  KAKENHI-PROJECT-25560219
[Presentation] 膵β細胞を標的とした核酸送達キャリアの構築およびin vivoへの応用2014
- Author(s)
  田端麻衣、山田勇磨、阿部二郎、野村政壽、原島秀吉
- Organizer
  第36回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  徳島大学大塚講堂、藤井節郎記念ホール(徳島県)
- Year and Date
  2014-11-21
- Data Source
  KAKENHI-PROJECT-26282131
[Presentation] MITO-Porter: Membrane-type nano device for mitochondrial drug delivery via membrane fusion2014
- Author(s)
  Hideyoshi Harashima and Yuma Yamada
- Organizer
  Euromit 2014
- Place of Presentation
  Tampere Hall (Finland)
- Year and Date
  2014-06-19
- Invited
- Data Source
  KAKENHI-PROJECT-26282131
[Presentation] ミトコンドリア標的型ナノデバイス”MITO-Porter”の創製.2014
- Author(s)
  山田勇磨
- Organizer
  日本薬学会第134年会奨励賞受賞講演
- Place of Presentation
  ホテル日航熊本 (熊本県)
- Invited
- Data Source
  KAKENHI-PROJECT-23680053
[Presentation] ミトコンドリア標的型核酸ナノキャリアの開発および遺伝子治療への挑戦2013
- Author(s)
  山田勇磨
- Organizer
  第29回日本DDS学会
- Place of Presentation
  京都テルサ(京都府)
- Year and Date
  2013-07-05
- Data Source
  KAKENHI-PROJECT-23680053
[Presentation] An approach to mitochondrial genesilencing by the mitochondrial delivery of anti-sense RNA2013
- Author(s)
  Y. Yamada, R. Furukawa, E. Kawamura, H. Harashima.
- Organizer
  40th Annual Meeting & Exposition of the Controlled Release Society.
- Place of Presentation
  Hawaii Convention Center (USA)
- Data Source
  KAKENHI-PROJECT-25560219
[Presentation] ヒアルロン酸コーティングナノキャリアの細胞内取り込み経路の解析2013
- Author(s)
  山田勇磨
- Organizer
  日本薬学会第133年会
- Place of Presentation
  パシフィコ横浜　（神奈川県）
- Data Source
  KAKENHI-PROJECT-23680053
[Presentation] ミトコンドリアを標的とした遺伝子発現制御の試み.2013
- Author(s)
  山田勇磨
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  ウインクあいち (愛知県)
- Data Source
  KAKENHI-PROJECT-23680053
[Presentation] An approach to mitochondrial genesilencing by the mitochondrial delivery of anti-sense RNA2013
- Author(s)
  Y. Yamada, R. Furukawa, E. Kawamura, H. Harashima.
- Organizer
  40th Annual Meeting & Exposition of the Controlled Release Society.
- Place of Presentation
  Hawaii Convention Center (USA)
- Data Source
  KAKENHI-PROJECT-23680053
[Presentation] 膵β細胞株MIN6細胞を標的としたDDS, β-MENDの構築および核酸導入・機能発現の検証2013
- Author(s)
  田端麻衣、山田勇磨、安崎友香理、野村政壽、柴田篤志、佐々木茂樹、原島秀吉
- Organizer
  日本薬学会北海道支部第140回例会
- Place of Presentation
  札幌コンベンションセンター (北海道)
- Data Source
  KAKENHI-PROJECT-25560219
[Presentation] ミトコンドリア標的型核酸ナノキャリアの開発および遺伝子治療への挑戦2013
- Author(s)
  山田勇磨
- Organizer
  第29回日本DDS学会
- Place of Presentation
  京都テルサ (京都府)
- Invited
- Data Source
  KAKENHI-PROJECT-25560219
[Presentation] Improvement of mitochondrial targeting activity of MITO-Porter using functional peptides2013
- Author(s)
  E. Kawamura, Y. Yamada, H. Harashima
- Organizer
  40th Annual Meeting & Exposition of the Controlled Release Society.
- Place of Presentation
  Hawaii Convention Center (USA)
- Data Source
  KAKENHI-PROJECT-25560219
[Presentation] ミトコンドリア標的型核酸ナノキャリアの開発および遺伝子治療への挑戦.2013
- Author(s)
  山田勇磨
- Organizer
  第29回日本DDS学会
- Place of Presentation
  京都テルサ (京都府)
- Invited
- Data Source
  KAKENHI-PROJECT-23680053
[Presentation] Improvement of mitochondrial targeting activity of MITO-Porter using functional peptides2013
- Author(s)
  E. Kawamura, Y. Yamada, H. Harashima.
- Organizer
  40th Annual Meeting & Exposition of the Controlled Release Society.
- Place of Presentation
  Hawaii Convention Center (USA)
- Data Source
  KAKENHI-PROJECT-23680053
[Presentation] ミトコンドリアを標的とした遺伝子発現制御の試み2013
- Author(s)
  山田勇磨、古川亮、原島秀吉
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  ウインクあいち (愛知県)
- Data Source
  KAKENHI-PROJECT-25560219
[Presentation] ミトコンドリア標的型DDSが拓くミトコンドリア創薬への道2012
- Author(s)
  山田勇磨
- Organizer
  日本薬学会第132年会一般シンポジウムS06
- Place of Presentation
  北海道大学(札幌)(招待講演)
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-23680053
[Presentation] ボンクレキン酸搭載MITO-Porterの構築およびミトコンドリア送達・抗アポトーシス効果の検証2012
- Author(s)
  中村宏平、山田勇磨, 他
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学(札幌)
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-23680053
[Presentation] Mitochondrial Medicineの創製を目指して2012
- Author(s)
  山田勇磨
- Organizer
  若手研究者公開特別シンポジウムミトコンドリアとDDS2
- Place of Presentation
  北海道大学(北海道)(招待講演)
- Year and Date
  2012-01-20
- Data Source
  KAKENHI-PROJECT-22229001
[Presentation] ミトコンドリアを標的とした遺伝子治療にむけて2012
- Author(s)
  古川亮、山田勇磨、原島秀吉
- Organizer
  日本薬学会第132年会一般シンポジウムS32-3
- Place of Presentation
  北海道大学(札幌)(招待講演)
- Year and Date
  2012-03-31
- Data Source
  KAKENHI-PROJECT-23680053
[Presentation] ミトコンドリアを標的とした遺伝子治療にむけて2012
- Author(s)
  山田勇磨
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学(北海道)(招待講演)
- Year and Date
  2012-03-31
- Data Source
  KAKENHI-PROJECT-22229001
[Presentation] Mitochondrial Delivery of Nucleic Acids by DF-MITO-Porter toward Mitochondrial Gene Therapy2012
- Author(s)
  Y. Yamada, H. Harashima
- Organizer
  3rd World Congress on Targeting Mitochondria
- Place of Presentation
  Ritz Carlton (Germany)
- Year and Date
  2012-11-09
- Data Source
  KAKENHI-PROJECT-23680053
[Presentation] 迅速・高効率な抗体デリバリーシステムの開2012
- Author(s)
  山田勇磨
- Organizer
  日本薬剤学会第27年会
- Place of Presentation
  神戸国際会議場（兵庫県）
- Data Source
  KAKENHI-PROJECT-23680053
[Presentation] 基調講演2012
- Author(s)
  山田勇磨
- Organizer
  若手研究者公開特別シンポジウムミトコンドリアとＤＤＳ 3
- Place of Presentation
  北海道大学薬学部　（札幌市）
- Data Source
  KAKENHI-PROJECT-23680053
[Presentation] Mitochondrial delivery of bioactive molecules using Dual Function (DF)-MITO-Porter2012
- Author(s)
  Y. Yamada
- Organizer
  39th Annual Meeting & Exposition of the Controlled Release Society
- Place of Presentation
  Quebec city convention centre (Canada)
- Data Source
  KAKENHI-PROJECT-23680053
[Presentation] Drug Delivery System and Mitochondria - Approach to Innovation of Mitochondrial Research, Mitochondrial Medicine Development and Mitochondrial Gene Therapy -2012
- Author(s)
  Y. Yamada
- Organizer
  Annual Spring Scientific Conference of the Korean Societyof Lipidology and Atherosclerosis (KSLA)
- Place of Presentation
  BEXCO (Korea)
- Year and Date
  2012-04-20
- Data Source
  KAKENHI-PROJECT-23680053
[Presentation] ミトコンドリア標的型DDSが拓くミトコンドリア創薬への道2012
- Author(s)
  山田勇磨
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学(北海道)(招待講演)
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-22229001
[Presentation] Mitochondrial Medicineの創製を目指して2012
- Author(s)
  山田勇磨
- Organizer
  若手研究者公開特別シンポジウムミトコンドリアとDDS2
- Place of Presentation
  北海道大学(札幌)(招待講演)
- Year and Date
  2012-01-20
- Data Source
  KAKENHI-PROJECT-23680053
[Presentation] ミトコンドリア(Mt)を標的とした遺伝子治療への挑戦-Dual Function MITO-Porterを用いたMtマトリクスへの核酸送達2011
- Author(s)
  山田勇磨, 他
- Organizer
  日本薬剤学会第26年会
- Place of Presentation
  タワーホテル船堀(東京)
- Data Source
  KAKENHI-PROJECT-23680053
[Presentation] ミトコンドリアとDDS～日本発・世界初の研究・技術・創薬を目指して～若手研究者公開特別シンポジウムミトコンドリアとDDS12011
- Author(s)
  山田勇磨
- Organizer
  (オーガナイザー:山田勇磨)
- Place of Presentation
  札幌
- Year and Date
  2011-01-21
- Data Source
  KAKENHI-PROJECT-21700483
[Presentation] Innovative approach to mitochondrial delivery of oligodeoxynucleotide using MITO-Porter, liposome-based carrier for mitochondrial delivery2011
- Author(s)
  Y.Yamada, et al.
- Organizer
  38th Annual Meeting & Exposition of the Controlled Release Society
- Place of Presentation
  Gaylord National Hotel and Convention Center (USA)
- Data Source
  KAKENHI-PROJECT-23680053
[Presentation] オクタアルギニン修飾リポソームによるレシチン化SOD (PC-SOD)の抗酸化効果の亢進2011
- Author(s)
  古川亮、山田勇磨, 他
- Organizer
  日本薬学会北海道支部第136回例会
- Place of Presentation
  札幌コンベンションセンター(北海道)
- Data Source
  KAKENHI-PROJECT-23680053
[Presentation] TECHNICAL APPLICATION OF HYDRODYNAMIC LIMB VEIN INJECTION FOR IN VIVO MITOCHONDRIAL GENE DELIVERY2011
- Author(s)
  Y.Yasuzaki, Y.Yamada, et al.
- Organizer
  5th SFRR-Asia, 8th ASMRM, 11th J-mit 2011 conference
- Place of Presentation
  Kagoshima Citizens' Culture Hall (Kagoshima)
- Year and Date
  2011-09-01
- Data Source
  KAKENHI-PROJECT-23680053
[Presentation] An innovative strategy for mitochondrial drug delivery using MITO-Porter, a liposome based nano-device that specifies fusion with mitochondrial membranes2011
- Author(s)
  Y.Yamada
- Organizer
  East & West Global Education Seminar Workshop, 26nd APSTJ Annual Meeting, Conference on Pharmaceutical Technology
- Place of Presentation
  Tower Hall Funabori (Tokyo)(招待講演)
- Year and Date
  2011-05-31
- Data Source
  KAKENHI-PROJECT-23680053
[Presentation] ミトコンドリア遺伝子を標的とした機能分子送達の試み2011
- Author(s)
  山田勇磨, 他
- Organizer
  第27回日本DDS学会
- Place of Presentation
  東京大学(東京都文京区)
- Data Source
  KAKENHI-PROJECT-23680053
[Presentation] An innovative omitochondr ve approach for mitochondrial gene delivery : mitochondrial delivery of oligo DNA using MITO-Porter, a liposome-based carrier foral delivery via membrane fusion2011
- Author(s)
  E.Kawamura, Y.Yamada, et al.
- Organizer
  5th SFRR-Asia, 8th ASMRM 11th J-mit 2011 conference
- Place of Presentation
  Kagoshima Citizens' Culture Hall (Kagoshima)
- Year and Date
  2011-09-01
- Data Source
  KAKENHI-PROJECT-23680053
[Presentation] EFFECT OF DNA PACKAGED WITH TFAM ON TRANSCRIPTION ACTIVATION2011
- Author(s)
  R.Furukawa, Y.Yamada, et al.
- Organizer
  5th SFRR-Asia, 8th ASMRM, 11th J-mit 2011 conference
- Place of Presentation
  Kagoshima Citizens' Culture Hall (Kagoshima)
- Year and Date
  2011-09-01
- Data Source
  KAKENHI-PROJECT-23680053
[Presentation] INNOVATIVE TECHNOLOGY FOR IN VIVO MITOCHONDRIAL GENE DELIVERY USING HYDRODYNAMIC LIMB VEIN INJECTION2011
- Author(s)
  Y.Yasuzaki, Y.Yamada, et al.
- Organizer
  第17回日本遺伝子治療学会学術集会
- Place of Presentation
  九州大学(福岡)
- Data Source
  KAKENHI-PROJECT-23680053
[Presentation] Hydrodynamic limb vein injection method can open an avenue of mitochondrial gene delivery in vivo2011
- Author(s)
  Y.Yasuzaki, Y.Yamada, et al.
- Organizer
  American Society of Gene & Cell Therapy 14th Annual Meeting
- Place of Presentation
  Washington State Convention & Trade Center (USA)
- Data Source
  KAKENHI-PROJECT-23680053
[Presentation] Mitochondrial genome targeting strategy : mitochondrial matrix delivery of bio-macromolecule using DF-MITO-Porter, an innovative nano carrier with cytoplasmic and mitochondrial fusogenic envelopes2011
- Author(s)
  Y.Yamada, et al.
- Organizer
  5th SFRR-Asia, 8th ASMRM, 11th J-mit 2011 conference
- Place of Presentation
  Kagoshima Citizens' Culture Hall (Kagoshima)
- Year and Date
  2011-09-01
- Data Source
  KAKENHI-PROJECT-23680053
[Presentation] 生分解性ポリロタキサンをモデルとしたpDNA、siRNAのナノ粒子形成に関する検討2011
- Author(s)
  橋田真裕、山田勇磨, 他
- Organizer
  日本薬学会北海道支部第136回例会
- Place of Presentation
  札幌コンベンションセンター(北海道)
- Data Source
  KAKENHI-PROJECT-23680053
[Presentation] ミトコンドリアとDDS～日本発・世界初の研究・技術・創薬を目指して～2011
- Author(s)
  山田勇磨
- Organizer
  若手研究者公開特別シンポジウムミトコンドリアとDDS 1
- Place of Presentation
  札幌(北海道大学)(招待講演)
- Year and Date
  2011-01-21
- Data Source
  KAKENHI-PROJECT-21700483
[Presentation] An innovative strategy for mitochondrial drug delivery using MITO-Porter, a liposome based nano-device that specifies fusion with mitochondrial membranes2011
- Author(s)
  Yuma Yamada
- Organizer
  26nd APSTJ Annual Meeting, Conference on Pharmaceutical Technology
- Place of Presentation
  Tower Hall Funabori(Tokyo)(招待講演)
- Year and Date
  2011-05-31
- Data Source
  KAKENHI-PROJECT-22229001
[Presentation] ミトコンドリア転写因子TFAM-プラスミドDNA複合体のin vitro転写評価2011
- Author(s)
  古川亮、山田勇磨, 他
- Organizer
  第27回日本DDS学会
- Place of Presentation
  東京大学(東京文京区)
- Data Source
  KAKENHI-PROJECT-23680053
[Presentation] MITO-Porterへのオリゴ核酸ナノ粒子パッケージングおよび生細胞ミトコンドリアを標的とした核酸送達の検討2011
- Author(s)
  河村恵理子、山田勇磨, 他
- Organizer
  日本薬学会北海道支部第136回例会
- Place of Presentation
  札幌コンベンションセンター(北海道)
- Data Source
  KAKENHI-PROJECT-23680053
[Presentation] ミトコンドリア標的型DDS、MITO-Porterを用いたオリゴ核酸送達の試み2011
- Author(s)
  河村恵理子、山田勇磨、原島秀吉
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡(ツインメッセ静岡)
- Data Source
  KAKENHI-PROJECT-21700483
[Presentation] Mitochondrial genome targeting by DF-MITO-Porter via endosomal and mitochondrial membrane fusion2011
- Author(s)
  Y.Yamada, et al.
- Organizer
  2nd World Congress on Targeting Mitochondria
- Place of Presentation
  The Ritz-Carlton (Germany)
- Year and Date
  2011-10-21
- Data Source
  KAKENHI-PROJECT-23680053
[Presentation] 生細胞ミトコンドリアDNAセンシング技術の開発2010
- Author(s)
  安崎友香理,山田勇磨、原島秀吉
- Organizer
  遺伝子・デリバリー研究会第10回シンポジウム
- Place of Presentation
  札幌(北海道大学)
- Data Source
  KAKENHI-PROJECT-21700483
[Presentation] Octaarginine-modified liposome enhances anti-oxidant effect of PC-SOD through the improvement of intracellular trafficking2010
- Author(s)
  古川亮、山田勇磨、武永美津子、五十嵐理慧、原島秀吉
- Organizer
  International liposome research days & lipids liposomes & membrane biophysic
- Place of Presentation
  Vancouver, Canada (University of British Columbia Campus)
- Data Source
  KAKENHI-PROJECT-21700483
[Presentation] Membrane fusions open a new avenue for mitochondrial delivery : Dual Function MITO-Porter, a nano-carrier system with cell and mitochondrial membranes-fusogenic activity2010
- Author(s)
  Y.Yamada, R.Furukawa, Y.Yasuzaki, H.Harashima.
- Organizer
  International liposome research days & lipids liposomes & membrane biophysic.
- Place of Presentation
  Vancouver, Canada.
- Data Source
  KAKENHI-PROJECT-21700483
[Presentation] Dual Function MITO-Porter, an innovative nano-carrier system for mitochondrial drug delivery2010
- Author(s)
  山田勇磨、古川亮、安崎友香理、原島秀吉
- Organizer
  FIP Pharmaceutical Sciences World Congress (PSWC) 2010
- Place of Presentation
  New Orleans, USA (Morial Convention Center)
- Data Source
  KAKENHI-PROJECT-21700483
[Presentation] Lighting a candle in mitochondria : Visualization of mitochondrial DNA using MITO-Porter, which is nano-device for mitochondrial delivery2010
- Author(s)
  安崎友香理、山田勇磨、原島秀吉
- Organizer
  International liposome research days & lipids liposomes & membrane biophysic
- Place of Presentation
  Vancouver, Canada (University of British Columbia Campus)
- Data Source
  KAKENHI-PROJECT-21700483
[Presentation] 効率的な細胞内導入を目的としたレシチン化SOD(PC-SOD)搭載R8リポソームの構築およびその機能評価2010
- Author(s)
  古川亮、山田勇磨、武永美津子、五十嵐理慧、原島秀吉
- Organizer
  日本薬剤学会第25年会
- Place of Presentation
  徳島(あわぎんホール)
- Data Source
  KAKENHI-PROJECT-21700483
[Presentation] “ボンクレキン酸(抗アポトーシス作動薬)搭載ミトコンドリア標的型DDS(MITO-Porter)の開発2010
- Author(s)
  山田勇磨、河村恵理子、安崎友香理、新藤充、原島秀吉
- Organizer
  第26回日本DDS学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21700483
[Presentation] Membrane fusions open a new avenue for mitochondrial delivery : Dual Function MITO-Porter, a nano-carrier system with cell and mitochondrial membranes-fusogenic activity2010
- Author(s)
  山田勇磨、古川亮、安崎友香理、原島秀吉
- Organizer
  International liposome research days & lipids liposomes & membrane biophysic
- Place of Presentation
  Vancouver, Canada (University of British Columbia Campus)
- Data Source
  KAKENHI-PROJECT-21700483
[Presentation] Dual Function MITO-Porter, an innovative nano-carrier system for mitochondrial drug delivery2010
- Author(s)
  Y.Yamada, R.Furukawa, Y.Yasuzaki, H.Harashima.
- Organizer
  FIP Pharmaceutical Sciences World Congress (PSWC) 2010.
- Place of Presentation
  New Orleans, USA.
- Data Source
  KAKENHI-PROJECT-21700483
[Presentation] DDS技術を基盤とした生細胞ミトコンドリアDNAの可視化2010
- Author(s)
  安崎友香理、山田勇磨、原島秀吉
- Organizer
  日本薬剤学会第25年会
- Place of Presentation
  徳島(あわぎんホール)
- Data Source
  KAKENHI-PROJECT-21700483
[Presentation] ボンクレキン酸(抗アポトーシス作動薬)搭載ミトコンドリア標的型DDS(MITO-Porter)の開発2010
- Author(s)
  山田勇磨、河村恵理子、安崎友香理、新藤充、原島秀吉
- Organizer
  第26回日本DDS学会
- Place of Presentation
  大阪(大阪国際交流センター)
- Data Source
  KAKENHI-PROJECT-21700483
[Presentation] ミトコンドリア標的型ナノデバイス"多重型MITO-Porter"の創製2009
- Author(s)
  山田勇磨
- Organizer
  第9回日本ミトコンドリア学会年会
- Place of Presentation
  東京(東京大学医学部鉄門記念講堂)
- Data Source
  KAKENHI-PROJECT-21700483
[Presentation] "ミトコンドリア標的型ナノデバイス"多重型MITO-Porter"の製剤化に関する検討2009
- Author(s)
  山田勇磨, 古川亮, 安崎友香理, 原島秀吉
- Organizer
  第25回日本DDS学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21700483
[Presentation] ミトコンドリア標的型ナノデバイス"多重型MITO-Porter"の創製2009
- Author(s)
  山田勇磨, 古川亮, 安崎友香理, 原島秀吉
- Organizer
  第9回日本ミトコンドリア学会年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21700483
[Presentation] A LIPOSOME-BASED NANO-DEVICE FOR MITOCHONDRIAL MACROMOLECULE DELIVERY VIA MEMBRANE FUSION-INNOVATIVE STRATEGY AIMED FOR MITOCHONDRIAL GENE THERAPYMITO-PORTER-2009
- Author(s)
  山田勇磨
- Organizer
  Joint Symposium of the 5th Annual Meeting of the Oligonucleotide Therapeutics Society and the 19th Antisense Symposium
- Place of Presentation
  Fukuoka, Japan(Centennial Hall, Kyushu University Hospital Campus)
- Data Source
  KAKENHI-PROJECT-21700483
[Presentation] "ミトコンドリア標的型ナノデバイス"多重型MITO-Porter"の有用性の検証2009
- Author(s)
  山田勇磨, 古川亮, 安崎友香理, 原島秀吉
- Organizer
  日本薬剤学会第24年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21700483
[Presentation] ミトコンドリア標的型ナノデバイス"多重型MITO-Porter"の有用性の検証2009
- Author(s)
  山田勇磨
- Organizer
  日本薬剤学会第24年会
- Place of Presentation
  静岡(静岡コンベンションアーツセンター)
- Data Source
  KAKENHI-PROJECT-21700483
[Presentation] MITO-PORTER : A LIPOSOME-BASED NANO-DEVICE FOR MITOCHONDRIAL MACROMOLECULE DELIVERY VIA MEMBRANE FUSION ?INNOVATIVE STRATEGY AIMED FOR MITOCHONDRIAL GENE THERAPY-2009
- Author(s)
  Y.Yamada, Y.Yasuzaki, R.Furukawa, H.Harashima.
- Organizer
  Joint Symposium of the 5th Annual Meeting of the Oligonucleotide Therapeutics Society and the 19th Antisense Symposium.
- Place of Presentation
  Fukuoka, Japan
- Data Source
  KAKENHI-PROJECT-21700483
[Presentation] ミトコンドリア標的型ナノデバイス"多重型MITO-Porter"の製剤化に関する検討2009
- Author(s)
  山田勇磨
- Organizer
  第25回日本DDS学会
- Place of Presentation
  東京(東京ドームホテル)
- Data Source
  KAKENHI-PROJECT-21700483
[Presentation] MITO-Porter : Nano Devicefor Mitochondrial Delivery-Mitochondrial Macromolecule DeliverySystem via Membrane Fusion-2008
- Author(s)
  Y. Yamada, H. Akita, H. Kamiya, H
- Organizer
  11th Liposome Research Days Conference (LRD2008)
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-19890001
[Presentation] MITO-Porter : Nano Device for Mitochondrial Delivery -Mitochondrial Macromolecule Delivery System via Menibrane Fusion-2008
- Author(s)
  山田勇磨
- Organizer
  11th Liposome Research Days Conference (LRD2008)
- Place of Presentation
  横浜(Ybkohama Symposia)
- Data Source
  KAKENHI-PROJECT-19890001
[Presentation] 多重型MITO-Porterによるミトコンドリアを標的とした薬物送達戦略2008
- Author(s)
  山田勇磨, 秋田英万, 紙谷浩之, 原島秀吉
- Organizer
  第24回日本DDS学会
- Place of Presentation
  東京(六本木アカデミーヒルズ40)
- Year and Date
  2008-06-30
- Data Source
  KAKENHI-PROJECT-19890001
[Presentation] 細胞内FRET法を用いたMITO-Porter(ミトコンドリア膜合融性リポソーム)の膜融合能評価2007
- Author(s)
  山田勇磨
- Organizer
  第23回日本DDS学会
- Place of Presentation
  熊本(熊本日航ホテル)
- Year and Date
  2007-06-14
- Data Source
  KAKENHI-PROJECT-19890001
[Presentation] MITO-Porter,a novel liposome-based mitochondrialdelivery system via membrane fusion2007
- Author(s)
  Y. Yamada, H. Akita, H. Kamiya, K. Kogure, Y. Shinohara, H. Kobayashi, H. Kikuchi, H. Harashima
- Organizer
  3rd Pharmaceutical Sciences WorldCongress (PSWC2007)
- Place of Presentation
  Amsterdam, The Netherlands
- Data Source
  KAKENHI-PROJECT-19890001
[Presentation] MITO-Porter, a novel liposome-based mitochondrial delivery system via membrane fusion.2007
- Author(s)
  山田勇磨
- Organizer
  3rd Pharmaceutical Sciences World Congress
- Place of Presentation
  Amsterdam, The Netherlands(RAI Congress centre)
- Data Source
  KAKENHI-PROJECT-19890001
[Presentation] 細胞内FRET法を用いたMITO-Porter(ミトコンドリア膜合融性リポソーム)の膜融合能評価2007
- Author(s)
  山田勇磨, 秋田英万, 紙谷浩之, 小暮健太朗, 篠原康雄, 原島秀吉
- Organizer
  第23回日本DDS学会
- Place of Presentation
  熊本
- Year and Date
  2007-06-14
- Data Source
  KAKENHI-PROJECT-19890001
[Presentation] ミトコンドリア標的型核酸ナノキャリアの開発と今後の展開
- Author(s)
  山田勇磨、原島秀吉
- Organizer
  第30回日本DDS学会学術集会
- Place of Presentation
  慶應義塾大学　薬学部　芝共立キャンパス（東京都）
- Year and Date
  2014-07-30 – 2014-07-31
- Data Source
  KAKENHI-PROJECT-26670741
[Presentation] 膵β細胞を標的とした核酸送達キャリアの構築およびin vivoへの応用
- Author(s)
  田端麻衣, 山田勇磨、野村政壽、原島秀吉
- Organizer
  第36回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  徳島大学
- Year and Date
  2014-11-20 – 2014-11-21
- Data Source
  KAKENHI-PROJECT-26461383

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Yamada Yuma 山田 勇磨

YAMADA Yuma 山田 勇磨

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ミトコンドリア遺伝子治療を実現するゲノム編集技術の創出Principal Investigator

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Development of Mitochondria-Targeted Nanocapsules for the Treatment of Neurological DisordersPrincipal Investigator

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Development of artificial mitochondria with cell-symbiosis abilityPrincipal Investigator

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Development of a nano device for mitochondrial gene editingPrincipal Investigator

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Yamada Yuma 山田勇磨

YAMADA Yuma 山田勇磨