Inoue Hiroaki 井上裕章

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INOUE HIROAKI 井上裕章

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Researcher Number	60457968
Other IDs
Affiliation (Current)	2025: 京都府立医科大学, 医学(系)研究科(研究院), 客員講師
Affiliation (based on the past Project Information) *help	2021 – 2022: 京都府立医科大学, 医学(系)研究科(研究院), 客員講師 2016 – 2020: 京都府立医科大学, 医学(系)研究科(研究院), 助教 2019: 京都府立医科大学, 医学(系)研究科(研究院), 学内講師 2016: 京都府立医科大学, 医学研究科, 講師
Review Section/Research Field	Principal Investigator Basic Section 56020:Orthopedics-related / Orthopaedic surgery Except Principal Investigator Orthopaedic surgery / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Rehabilitation science/Welfare engineering
Keywords	Principal Investigator 変形性関節症 / ヒアルロン酸 / 低酸素 / HYBID / 老化 / 軟骨代謝 / HSP70 / Sirt1 / 温熱ストレス / SIRT1 … More / 軟骨 / β-TCP / β‐TCP / PRP / 移植腱再構築 / 前十字靱帯再建術 / 組織学的検討 / 移植腱 … More Except Principal Investigator 軟骨 / 軟骨代謝 / 整形外科学 / 変形性関節症 / カチオン化 / 骨軟骨代謝学 / ヒアルロン酸 / ストレス / リハビリテーション / 整形外科 / 低酸素 / 運動療法 / HIF-1α / 伸展刺激 / メカニカルストレス / 低酸素環境 / siRNA / 線維芽細胞 / 筋線維芽細胞 / 線維化疾患 / HSP47 / 筋損傷 / iPS細胞 / 硝子軟骨 / 再生医学 / 軟骨分化 / 物理刺激 / 幹細胞 / 再生医療 Less

Pioneering Treatment of Osteoarthritis by Regulation of HYBID, in HypoxiaPrincipal Investigator
- Principal Investigator
  
  Inoue Hiroaki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Kyoto Prefectural University of Medicine
Development of charge based DDS for OA based on the negative charge of aggrecan
- Principal Investigator
  
  Kubo Toshikazu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Kyoto Prefectural University of Medicine
Investigation of the role of SIRT1 in the stress response of chondrocytesPrincipal Investigator
- Principal Investigator
  
  Inoue Hiroaki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Kyoto Prefectural University of Medicine
Development of HIF-1a-induced exercise therapy focusing on the intra-articular hypoxic environment
- Principal Investigator
  
  Arai Yuji
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Rehabilitation science/Welfare engineering
- Research Institution
  Kyoto Prefectural University of Medicine
Development of a new method for regenerating hyaline cartilage using a bioreactor for iPS cells
- Principal Investigator
  
  Kubo Toshikazu
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyoto Prefectural University of Medicine
ACR reconstruction using PRP and beta-TCPPrincipal Investigator
- Principal Investigator
  
  Inoue Hiroaki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyoto Prefectural University of Medicine
Development of treatment for muscle injury without scar healing focused on inhibition of myofibroblasts
- Principal Investigator
  
  Nakagawa Shuji
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyoto Prefectural University of Medicine

All 2022 2021 2020 2019 2018 2017 2016 2015 Other

All Journal Article Presentation

[Journal Article] Relationship of alignment in the lower extremity with early degeneration of articular cartilage after resection of the medial meniscus2020
- Author(s)
  Nakagawa Shuji、Arai Yuji、Inoue Hiroaki、Fujii Yuta、Kaihara Kenta、Mikami Yasuo
- Journal Title
  
  Medicine
  
  Volume: 99 Issue: 44 Pages: e22984-e22984
- DOI
  10.1097/md.0000000000022984
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K10752, KAKENHI-PROJECT-18K16630
[Journal Article] Treadmill Running in Established Phase Arthritis Inhibits Joint Destruction in Rat Rheumatoid Arthritis Models2019
- Author(s)
  Fujii Yuta、Inoue Hiroaki、Arai Yuji、Shimomura Seiji、Nakagawa Shuji、Kishida Tsunao、Tsuchida Shinji、Kamada Yoichiro、Kaihara Kenta、Shirai Toshiharu、Terauchi Ryu、Toyama Shogo、Ikoma Kazuya、Mazda Osam、Mikami Yasuo
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Issue: 20 Pages: 5100-5100
- DOI
  10.3390/ijms20205100
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K19914, KAKENHI-PROJECT-17H02136, KAKENHI-PROJECT-17H04316, KAKENHI-PROJECT-20K11214
[Journal Article] Treadmill Running Ameliorates Destruction of Articular Cartilage and Subchondral Bone, Not Only Synovitis, in a Rheumatoid Arthritis Rat Model.2018
- Author(s)
  Shimomura S, Inoue H, Arai Y, Nakagawa S, Fujii Y, Kishida T, Ichimaru S, Tsuchida S, Shirai T, Ikoma K, Mazda O, Kubo T.
- Journal Title
  
  Int J Mol Sci
  
  Volume: 19 Issue: 6 Pages: 1653-1653
- DOI
  10.3390/ijms19061653
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K10752, KAKENHI-PROJECT-17H02136, KAKENHI-PROJECT-16K15669, KAKENHI-PROJECT-17H04316
[Presentation] Sustained hypoxia suppresses the production of pro-inflammatory cytokines in rheumatoid arthritis synovial cell via negative feedback of HIF-1α2022
- Author(s)
  Kaihara K, Nakagawa S, Inoue H, Inoue A, Arai Y, Fujii Y, Kamada Y, Cha R, Mazda O, Takahashi K
- Organizer
  2022 ORS annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09507
[Presentation] Influence of heat stress on SIRT1-transfected chondrocytes2021
- Author(s)
  Kaihara K, Inoue H, Nakagawa S, Arai Y, Fujii Y, Mazda O, Takahashi K
- Organizer
  2021 Annual Meeting of Orthopaedic Research Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16630
[Presentation] Influence of heat stress on SIRT1-transfected chondrocytes2021
- Author(s)
  Kaihara K, Inoue H, Nakagawa S, Arai Y, Fujii Y, Mazda O, Takahashi K
- Organizer
  2021 Annual Meeting of Orthopaedic Research Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09507
[Presentation] Influence of heat stress on SIRT1-transfected chondrocytes2021
- Author(s)
  Kaihara K, Inoue H, Nakagawa S, Arai Y, Fujii Y, Mazda O, Takahashi K
- Organizer
  2021 Annual Meeting of Orthopaedic Research Society(国際学会)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09507
[Presentation] 酸素濃度がヒトiPS細胞から軟骨組織への分化に与える影響2021
- Author(s)
  藤井雄太，井上裕章，下村征史，中川周士，市丸昌平，鎌田陽一郎，貝原健太，松田　修，新井祐志
- Organizer
  第33回日本軟骨代謝学会
- Data Source
  KAKENHI-PROJECT-18K19620
[Presentation] SIRT1導入細胞に対する温熱ストレスの検討2020
- Author(s)
  貝原健太，井上裕章，中川周士，新井祐志，藤井雄太，松田　修，高橋謙治
- Organizer
  第35回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-18K16630
[Presentation] Treadmill running suppressed joint destruction in a rheumatoid arthritis rat model2020
- Author(s)
  Fujii Y, Inoue H, Arai Y, Shimomura S, Nakagawa S, Tsuchida S, Kamada Y, Kaihara K, Mazda O, Mikami Y
- Organizer
  66th Annual Meeting of Orthopaedic Research Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19620
[Presentation] Effect Of Hif-1α Stabilization By Deferoxamine On Chondrocyte And Articular Cartilage2020
- Author(s)
  Kaihara Kenta、Nakagawa Shuji、Arai Yuji、Fujii Yuta、Inoue Hiroaki、Tsuchida Shinji、Kamada Yoichiro、Mazda Osam、Mikami Yasuo
- Organizer
  66th Annual Meeting of Orthopaedic Research Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H02136
[Presentation] トレッドミル走行がラット関節炎モデルの足関節に与える影響2020
- Author(s)
  藤井雄太，井上裕章，中川周士，下村征史，新井祐志，松田　修，高橋謙治
- Organizer
  第35回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-18K19620
[Presentation] Effect Of Hif-1α Stabilization By Deferoxamine On Chondrocyte And Articular Cartilage2020
- Author(s)
  Kaihara Kenta、Nakagawa Shuji、Arai Yuji、Fujii Yuta、Inoue Hiroaki、Tsuchida Shinji、Kamada Yoichiro、Mazda Osam、Mikami Yasuo
- Organizer
  66th Annual Meeting of Orthopaedic Research Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05452
[Presentation] Analysis Of Reaction To Tensile Stress In Chondrocytes In Hypoxic Environment2020
- Author(s)
  Yoichiro Kamada; Hiroaki Inoue; Yuji Arai; Seiji Shimomura; Shuji Nakagawa; Shinji Tsuchida; Yuta Fujii; Kenta Kaihara; Osam Mazda; Yasuo Mikami
- Organizer
  2020 Annual Meeting of Orthopaedic Research Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19620
[Presentation] Effect of HIF-1α stabilization by deferoxamine on chondrocyte and articular cartilage2020
- Author(s)
  Kaihara K, Nakagawa S, Arai Y, Fujii Y, Inoue H, Tsuchida S, Kamada Y, Mazda O, Mikami Y
- Organizer
  2020 Annual Meeting of Orthopaedic Research Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16630
[Presentation] SIRT1導入細胞に対する温熱ストレスの検討2020
- Author(s)
  貝原健太，井上裕章，中川周士，新井祐志，藤井雄太，松田修，高橋謙治
- Organizer
  第35回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-20K09507
[Presentation] Analysis Of Reaction To Tensile Stress In Chondrocytes In Hypoxic Environment2020
- Author(s)
  Kamada Yoichiro、Inoue Hiroaki、Arai Yuji、Shimomura Seiji、Nakagawa Shuji、Tsuchida Shinji、Fujii Yuta、Kaihara Kenta、Mazda Osam、Mikami Yasuo
- Organizer
  66th Annual Meeting of Orthopaedic Research Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H02136
[Presentation] CIAラットを用いたtreadmill走行の骨破壊へ与える影響の検討2019
- Author(s)
  貝原健太，井上裕章，中川周士，新井祐志，土田真嗣，下村征史，藤井雄太，松田　修，久保俊一
- Organizer
  第34回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-18K16630
[Presentation] Treadmill running ameliorates articular cartilage destruction and synovitis in a rheumatoid arthritis rat model2019
- Author(s)
  Fujii Y, Inoue H, Arai Y, Nakagawa S, Tsuchida S, Shimomura S, Mazda O, Kubo T
- Organizer
  65th Annual Meeting of Orthopaedic Research Society
- Data Source
  KAKENHI-PROJECT-18K16630
[Presentation] Hypoxic Condition Promotes Differentiation From Human iPSC to Cartilage2019
- Author(s)
  Shimomura S, Inoue H, Arai Y, Nakagawa S, Tsuchida S, Ichimaru S, Fujii Y, Mazda O, Kubo T
- Organizer
  65th Annual Meeting of Orthopaedic Research Society
- Data Source
  KAKENHI-PROJECT-17H02136
[Presentation] 低酸素環境下における伸展刺激に対する軟骨細胞のストレス応答解析2019
- Author(s)
  鎌田陽一郎、井上裕章、新井祐志、下村征史、中川周士、土田真嗣、松田　修、久保俊一
- Organizer
  日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-17H02136
[Presentation] Histological evaluation of treadmill running on knee joint of rat arthritis model2018
- Author(s)
  Fujii Y, Inoue H, Arai Y, Nakagawa S, Tsuchida S, Shimomura S, Mazda O, Kubo T
- Organizer
  26th Annual Meeting of European Orthopaedic Reserch Society
- Data Source
  KAKENHI-PROJECT-17H02136
[Presentation] ヒトiPS細胞から軟骨組織分化における酸素濃度の影響の検討2018
- Author(s)
  下村征史，井上裕章，新井祐志，中川周士，土田真嗣，市丸昌平，藤井雄太，松田　修，久保俊一
- Organizer
  第33回日本整形外科基礎学術集会
- Data Source
  KAKENHI-PROJECT-18K19620
[Presentation] The effects of treadmill exercise at a single time on knee articular cartilage in vivo2018
- Author(s)
  Shimomura S, Inoue H, Arai Y, Nakagawa S, Tsuchida S, Ichimaru S, Fujii Y, Mazda O, Kubo T
- Organizer
  26th Annual Meeting of European Orthopaedic Reserch Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19620
[Presentation] トレッドミル走行がラット関節炎モデルの膝関節に与える組織学的評価2018
- Author(s)
  藤井雄太，井上裕章，新井祐志，中川周士，土田真嗣，下村征史，松田　修，久保俊一
- Organizer
  第33回日本整形外科基礎学術集会
- Data Source
  KAKENHI-PROJECT-17H02136
[Presentation] Effects of hypoxic conditions in differentiation of human iPSC to cartilage2018
- Author(s)
  Seiji Shimomura, Hiroaki Inoue, Yuji Arai, Shuji Nakagawa, Shinji Tsuchida, Shohei Ichimaru, Yuta Fujii, Osamu Mazda, Toshikazu Kubo
- Organizer
  2018　ORS　annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05452
[Presentation] Effects of hypoxic conditions in differentiation of human iPSC to cartilage2018
- Author(s)
  Seiji Shimomura, Hiroaki Inoue, Yuji Arai, Shuji Nakagawa, Shinji Tsuchida,Shohei Ichimaru, Yuta Fujii, Osamu Mazda, Toshikazu Kubo
- Organizer
  64th Annual Meeting of Orthopaedic Research Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H02136
[Presentation] HIF-1α in articular cartilage is up-regulated by treadmill running in vivo2018
- Author(s)
  Fujii Y, Inoue H, Arai Y, Nakagawa S, Tsuchida S, Shimomura S, Mazda O, Kubo T
- Organizer
  21st World Congress of the Osteoarthritis Research Society International (OARSI)
- Data Source
  KAKENHI-PROJECT-17H02136
[Presentation] The relationship between treadmill running and HIF-2α on rat knee articular cartilage2018
- Author(s)
  Shimomura S, Inoue H, Arai Y, Nakagawa S, Tsuchida S, Ichimaru S, Fujii Y, Mazda O, Kubo T
- Organizer
  21st World Congress of the Osteoarthritis Research Society International (OARSI)
- Data Source
  KAKENHI-PROJECT-18K16630
[Presentation] Regulation of inflammatory cytokine expression and osteoclastgenesis by gap junctional protein in vitro and in vivo.2017
- Author(s)
  Seiji Shimomura, Shinji Tsuchida, Yuji Arai, Shuji Nakagawa, Hiroaki Inoue, Shohei Ichimaru, Yuta Fujii, Osam Mazda, Toshikazu Kubo
- Organizer
  The 5th annual meeting of the international cytokine and interferon society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H02136
[Presentation] The effect of treadmill running on knee articular cartilage in rats2017
- Author(s)
  Seiji Shimomura, Hiroaki Inoue, Yuji Arai, Shuji Nakagawa, Shinji Tsuchida, Shohei Ichimaru, Osam Mazda, Toshikazu Kubo
- Organizer
  20th World Congress of the Osteoarthritis Research Society International (OARSI)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H02136
[Presentation] 低酸素環境によるヒトiPS細胞から軟骨組織への分化促進効果の検討2017
- Author(s)
  下村征史，井上裕章，新井祐志，中川周士，土田真嗣，市丸昌平，松田　修，久保俊一
- Organizer
  第32回日本整形外科基礎学術集会
- Data Source
  KAKENHI-PROJECT-16H05452
[Presentation] Regulation of inflammatory cytokine expression and osteoclastgenesis by gap junctional protein in vitro and in vivo2017
- Author(s)
  Seiji Shimomura, Shinji Tsuchida, Yuji Arai, Shuji Nakagawa, Hiroaki Inoue, Shohei Ichimaru, Yuta Fujii, Osam Mazda, Toshikazu Kubo
- Organizer
  The 5th annual meeting of the international cytokine and interferon society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20065
[Presentation] Open MRIを用いた膝蓋骨脱臼膝に対する内側膝蓋大腿靭帯再建前後の靭帯走行形態の変化2016
- Author(s)
  中川周士、新井裕志、井上裕章、菅寛之、日野学、市丸昌平、久保俊一
- Organizer
  第8回日本関節鏡・膝・スポーツ整形外科学会
- Place of Presentation
  福岡
- Year and Date
  2016-07-28
- Data Source
  KAKENHI-PROJECT-26861204
[Presentation] HSP70 induced by HIF-1α regulates anabolic responses in chondrocytes under hypoxic conditions2015
- Author(s)
  Honjo K, Arai Y, Tsuchida S, Nakagawa S, Inoue H, Saito M, Ichimaru S, Shimomura S, Inoue A, Terauchi R, Mazda O, Kubo T
- Organizer
  18th World Congress of the Osteoarthritis Research Society International (OARSI)
- Place of Presentation
  Seattle, USA
- Year and Date
  2015-04-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26861204
[Presentation] トレッドミル走行運動がラット膝関節軟骨に与える影響
- Author(s)
  松木智宏，新井祐志，土田真嗣，中川周士，井上裕章，市丸昌平，井上敦夫，外村　仁，寺内　竜，松田　修，久保俊一
- Organizer
  第29回日本整形外科学会基礎学術集会
- Place of Presentation
  鹿児島
- Year and Date
  2014-10-09 – 2014-10-10
- Data Source
  KAKENHI-PROJECT-26861204

1. Nakagawa Shuji (30643382)

# of Collaborated Projects: 5 results

# of Collaborated Products: 28 results
2. Arai Yuji (50347449)

# of Collaborated Projects: 4 results

# of Collaborated Products: 25 results
3. Kubo Toshikazu (20178031)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
4. MORIHARA TORU (90336735)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 松田修 (00271164)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. 遠山将吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Inoue Hiroaki 井上 裕章

INOUE HIROAKI 井上 裕章

Research Projects

Research Products

Co-Researchers

Pioneering Treatment of Osteoarthritis by Regulation of HYBID, in HypoxiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of charge based DDS for OA based on the negative charge of aggrecan

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of the role of SIRT1 in the stress response of chondrocytesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of HIF-1a-induced exercise therapy focusing on the intra-articular hypoxic environment

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a new method for regenerating hyaline cartilage using a bioreactor for iPS cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ACR reconstruction using PRP and beta-TCPPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of treatment for muscle injury without scar healing focused on inhibition of myofibroblasts

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Relationship of alignment in the lower extremity with early degeneration of articular cartilage after resection of the medial meniscus2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Treadmill Running in Established Phase Arthritis Inhibits Joint Destruction in Rat Rheumatoid Arthritis Models2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Treadmill Running Ameliorates Destruction of Articular Cartilage and Subchondral Bone, Not Only Synovitis, in a Rheumatoid Arthritis Rat Model.2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] Sustained hypoxia suppresses the production of pro-inflammatory cytokines in rheumatoid arthritis synovial cell via negative feedback of HIF-1α2022

Author(s)

Organizer

Data Source

[Presentation] Influence of heat stress on SIRT1-transfected chondrocytes2021

Author(s)

Organizer

Data Source

[Presentation] Influence of heat stress on SIRT1-transfected chondrocytes2021

Author(s)

Organizer

Data Source

[Presentation] Influence of heat stress on SIRT1-transfected chondrocytes2021

Author(s)

Organizer

Data Source

[Presentation] 酸素濃度がヒトiPS細胞から軟骨組織への分化に与える影響2021

Author(s)

Inoue Hiroaki 井上裕章

INOUE HIROAKI 井上裕章