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KAZUMATA Ken  数又 研

ORCIDConnect your ORCID iD *help
Researcher Number 60634144
Other IDs
Affiliation (based on the past Project Information) *help 2013 – 2021: 北海道大学, 大学病院, 講師
Review Section/Research Field
Principal Investigator
Neurosurgery
Except Principal Investigator
Neurosurgery / Basic Section 56010:Neurosurgery-related / Basic Section 59010:Rehabilitation science-related
Keywords
Principal Investigator
もやもや病 / iPS細胞 / 血管内皮細胞 / 内皮細胞 / バリア機能 / tight junction
Except Principal Investigator
もやもや病 / 人工酸素運搬体 / 脳梗塞 / 虚血再灌流傷害 … More / RNF213 / 家族性もやもや病 / 表現促進現象 / 遺伝子コピー数多型 / 家族内発症 / コピー数多型 / 脳微小血管 / 細胞老化 / SIRT1 / 脳動脈瘤 / 脳動脈瘤破裂 / 大型脳動脈瘤 / 動物モデル / 抗血小板剤 / ラット / くも膜下出血 / 血行力学的負荷 / 内皮 / ニトロ化合物 / 高血圧 / iPS細胞 / 平滑筋細胞 / 血管平滑筋細胞 / 神経堤 / 神経堤細胞 / 脳保護療法 / 冷却灌流 / 虚血再灌流障害 / 活性酸素 / 脳低温療法 / biomaterial / embolization / Intervention / hydrogel / hypervascular tumor / ハイドロゲル / X線視認性 / 粒子塞栓物質 / ラット系頸動脈投与 / CT / ソフトマターテクノロジー / X線不透過 / 塞栓物質 / ソフトマター / 脳神経疾患 / トランスレーショナルリサーチ / 高分子合成 / 遺伝子変異 / moyamoya病 / 遺伝子多型 / 浅側頭動脈 / ピロリ菌感染 / エクソソーム / ピロリ菌 / 抗酸化物質 / 脳保護作用 / 認知リハビリテーション / トレーニング効果 / resting-state fMRI / computer-based training / 健常者 / 認知機能トレーニング / 脳MRI / 神経心理学的検査 / Moyamoya disease / circulating microRNA / blood biomarker / epigenome / 発症素因 / 病態修飾因子 / 血漿microRNA / エピゲノム / 創始者変異 Less
  • Research Projects

    (11 results)
  • Research Products

    (24 results)
  • Co-Researchers

    (24 People)
  •  抗酸化作用を付与した人工酸素運搬体による脳梗塞治療法の開発

    • Principal Investigator
      鐙谷 武雄
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Hokkaido University
  •  Establishment of neurocognitive training to improve frontal lobe function in moyamoya disease

    • Principal Investigator
      澤村 大輔
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 59010:Rehabilitation science-related
    • Research Institution
      Hokkaido University
  •  Comprehensive validation of circulating microRNA signatures for Moyamoya disease early detection as an epigenome blood biomarker

    • Principal Investigator
      伊東 雅基
    • Project Period (FY)
      2019 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Hokkaido University
  •  Relationship between Chronic inflammation and progression of Moyamoya disease

    • Principal Investigator
      Hokari Masaaki
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Hokkaido University
  •  Development of visible particle embolic material used by new concept hydrogel

    • Principal Investigator
      Osanai Toshiya
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurosurgery
    • Research Institution
      Hokkaido University
  •  Development of neuroprotective therapy with selective intra-arterial infusion of cold artificial oxygen carrier

    • Principal Investigator
      Abumiya Takeo
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurosurgery
    • Research Institution
      Hokkaido University
  •  Investigation of barrier function of endothelial cells derived from moyamoya disease-specific iPS cellsPrincipal Investigator

    • Principal Investigator
      KAZUMATA Ken
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurosurgery
    • Research Institution
      Hokkaido University
  •  Development of an anti-rupture drug treatment method using a novel animal model of easily rupturable large cerebral aneurysm and human clinical specimen

    • Principal Investigator
      NAKAYAMA Naoki
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurosurgery
    • Research Institution
      Hokkaido University
  •  Induction of smooth muscle cells from iPS cells derived from moyamoya disease patient

    • Principal Investigator
      Houkin Kiyohiro
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Neurosurgery
    • Research Institution
      Hokkaido University
  •  Genome-wide CNV array analysis in parent-offspring pairs with Moyamoya disease with and without clinical anticipation

    • Principal Investigator
      Yoshimoto Tetsuyuki
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurosurgery
    • Research Institution
      Hokkaido University
  •  The role of SIRT1 in cellular senescence and characteristics in brain microvascular endothelial cells

    • Principal Investigator
      HOUKIN Kiyohiro
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Neurosurgery
    • Research Institution
      Hokkaido University

All 2022 2021 2020 2019 2018 2017 2016 2015 2014

All Journal Article Presentation

  • [Journal Article] Impact of RNF213 founder polymorphism (p.R4810K) on the postoperative development of indirect pial synangiosis after direct/indirect combined revascularization surgery for adult Moyamoya disease2022

    • Author(s)
      Ito Masaki、Kawabori Masahito、Sugiyama Taku、Tokairin Kikutaro、Tatezawa Ryota、Uchino Haruto、Kazumata Ken、Houkin Kiyohiro、Fujimura Miki
    • Journal Title

      Neurosurgical Review

      Volume: online ahead of print

    • DOI

      10.1007/s10143-022-01749-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03765, KAKENHI-PROJECT-20K09362
  • [Journal Article] Crossed cerebellar diaschisis as an indicator of severe cerebral hyperperfusion after direct bypass for moyamoya disease2020

    • Author(s)
      Uchino Haruto、Kazumata Ken、Ito Masaki、Nakayama Naoki、Kuroda Satoshi、Houkin Kiyohiro
    • Journal Title

      Neurosurgical Review

      Volume: 44 Pages: 599-605

    • DOI

      10.1007/s10143-020-01265-8

    • NAID

      120006958359

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03765
  • [Journal Article] Association of cognitive function with cerebral blood flow in children with moyamoya disease2020

    • Author(s)
      Kazumata Ken、Tokairin Kikutaro、Sugiyama Taku、Ito Masaki、Uchino Haruto、Osanai Toshiya、Kawabori Masahito、Nakayama Naoki、Houkin Kiyohiro
    • Journal Title

      Journal of Neurosurgery: Pediatrics

      Volume: 25 Pages: 62-68

    • DOI

      10.3171/2019.7.peds19312

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03765
  • [Journal Article] Complication rate, cure rate, and long-term outcomes of microsurgery for intracranial dural arteriovenous fistulae: a multicenter series and systematic review2020

    • Author(s)
      Sugiyama Taku、Nakayama Naoki、Ushikoshi Satoshi、Kazumata Ken、Okamoto Michinari、Ito Masaki、Osanai Toshiya、Shimoda Yusuke、Uchida Kazuki、Shimbo Daisuke、Ito Yasuhiro、Asaoka Katsuyuki、Nakamura Toshitaka、Kuroda Satoshi、Houkin Kiyohiro
    • Journal Title

      Neurosurgical Review

      Volume: 44 Pages: 435-450

    • DOI

      10.1007/s10143-019-01232-y

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03765
  • [Journal Article] Immersive 3-Dimensional Virtual Reality Modeling for Case-Specific Presurgical Discussions in Cerebrovascular Neurosurgery2020

    • Author(s)
      Sugiyama Taku、Clapp Tod、Nelson Jordan、Eitel Chad、Motegi Hiroaki、Nakayama Naoki、Sasaki Tsukasa、Tokairin Kikutaro、Ito Masaki、Kazumata Ken、Houkin Kiyohiro
    • Journal Title

      Operative Neurosurgery

      Volume: 20 Pages: 289-299

    • DOI

      10.1093/ons/opaa335

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03765
  • [Journal Article] Vascular Smooth Muscle Cell Derived from IPS Cell of Moyamoya Disease - Comparative Characterization with Endothelial Cell Transcriptome2020

    • Author(s)
      Tokairin Kikutaro、Hamauchi Shuji、Ito Masaki、Kazumata Ken、Sugiyama Taku、Nakayama Naoki、Kawabori Masahito、Osanai Toshiya、Houkin Kiyohiro
    • Journal Title

      Journal of Stroke and Cerebrovascular Diseases

      Volume: 29 Pages: 105305-105305

    • DOI

      10.1016/j.jstrokecerebrovasdis.2020.105305

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03765
  • [Journal Article] Brain Structure, Connectivity, and Cognitive Changes Following Revascularization Surgery in Adult Moyamoya Disease2019

    • Author(s)
      Kazumata Ken、Tha Khin Khin、Tokairin Kikutaro、Ito Masaki、Uchino Haruto、Kawabori Masahito、Sugiyama Taku
    • Journal Title

      Neurosurgery

      Volume: 85

    • DOI

      10.1093/neuros/nyz176

    • Data Source
      KAKENHI-PROJECT-19H03765
  • [Journal Article] Novel Hemoglobin-Based Oxygen Carrier Bound With Albumin Shows Neuroprotection With Possible Antioxidant Effects2018

    • Author(s)
      Gekka Masayuki、Abumiya Takeo、Komatsu Teruyuki、Funaki Ryosuke、Kurisu Kota、Shimbo Daisuke、Kawabori Masato、Osanai Toshiya、Nakayama Naoki、Kazumata Ken、Houkin Kiyohiro
    • Journal Title

      Stroke

      Volume: 49 Pages: 1960-1968

    • DOI

      10.1161/strokeaha.118.021467

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K10708
  • [Journal Article] Surgical Outcome of Cerebral Aneurysm Clipping Treated with Immunosuppressants: Report of 11 Cases and Review of the Literature2017

    • Author(s)
      Hokari M, Nakayama N, Kazumata K, Osanai T, Shichinohe H, Abumiya T, Houkin K.
    • Journal Title

      Neurologia medico-chirurgica

      Volume: 57(3) Issue: 3 Pages: 122-127

    • DOI

      10.2176/nmc.oa.2016-0185

    • NAID

      130005439797

    • ISSN
      0470-8105, 1349-8029
    • Language
      English
    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K10284, KAKENHI-PROJECT-15K10287
  • [Journal Article] 表現促進現象を有する家族性もやもや病のCNV解析 -研究デザインと進捗報告-2014

    • Author(s)
      伊東 雅基、宝金 清博、佐々木秀直、濱 結香、数又 研
    • Journal Title

      厚生労働科学研究費補助金(難治性疾患克服研究事業) 分担研究報告書

      Volume: 印刷中

    • Data Source
      KAKENHI-PROJECT-25462203
  • [Presentation] RNF213創始者変異は成人もやもや病複合血行再建術後の間接バイパス路発達に寄与する2021

    • Author(s)
      伊東 雅基, 川堀 真人, 杉山 拓, 東海林 菊太郎, 舘澤 諒大, 内野 晴登, 数又 研, 寳金 清博, 藤村 幹
    • Organizer
      第80回日本脳神経外科学会学術総会
    • Data Source
      KAKENHI-PROJECT-19H03765
  • [Presentation] 成人もやもや病複合血行再建術後バイパス路発達度におけるRNF213創始者変異の意義2021

    • Author(s)
      伊東 雅基、川堀 真人、杉山 拓、東海林 菊太郎、舘澤 諒大、内野 晴登、数又 研、寳金 清博、藤村 幹
    • Organizer
      第39回 The Mt. Fuji workshop on CVD
    • Data Source
      KAKENHI-PROJECT-19H03765
  • [Presentation] RNF213創始者変異は成人もやもや病複合血行再建術後の間接バイパス路発達に寄与する2021

    • Author(s)
      伊東 雅基, 川堀 真人, 杉山 拓, 東海林 菊太郎, 舘澤 諒大, 内野 晴登, 数又 研, 寳金 清博, 藤村 幹
    • Organizer
      第64回 日本脳循環代謝学会学術集会
    • Data Source
      KAKENHI-PROJECT-19H03765
  • [Presentation] 成人もやもや病に対する間接バイパス術に残された課題ーRNF213創始者変異術前検討の意義2021

    • Author(s)
      伊東 雅基, 川堀 真人, 杉山 拓, 東海林 菊太郎, 舘澤 諒大, 内野 晴登, 数又 研, 寳金 清博, 藤村 幹
    • Organizer
      第51回 日本脳卒中の外科学会学術集会
    • Data Source
      KAKENHI-PROJECT-19H03765
  • [Presentation] 脳虚血再灌流傷害急性期微小循環障害に対するヘモグロビン‐アルブミン複合型人工酸素運搬体HemoActの効果の検討2019

    • Author(s)
      [演者] 月花 正幸: [共同演者]鐙谷 武雄, 小松晃之、舟木亮佑、栗栖宏多、新保大輔、伊藤 康裕::, 中山 若樹:, 数又 研:, 寳金 清博:
    • Organizer
      第44回日本脳卒中学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K10708
  • [Presentation] もやもや病生体試料バンク構築とエピゲノム血液バイオマーカー探索2019

    • Author(s)
      伊東雅基,数又研,寳金清博,他
    • Organizer
      第44回日本脳卒中学会総会シンポジウム(Stroke2019)
    • Data Source
      KAKENHI-PROJECT-19H03765
  • [Presentation] もやもや病の脳構造機能解析-慢性虚血によるmicro ischemic injuryの描出2019

    • Author(s)
      伊東雅基,数又研,寳金清博,他
    • Organizer
      第44回日本脳卒中学会総会シンポジウム(Stroke2019)
    • Data Source
      KAKENHI-PROJECT-19H03765
  • [Presentation] 脳虚血再灌流傷害に対するアルブミン結合型人工酸素運搬体HemoActの脳保護効果の作用機序―微小循環・酸素運搬能改善と抗酸化作用―2018

    • Author(s)
      [演者] 鐙谷 武雄: [共同演者] 月花 正幸, 伊藤 康裕:, 川堀 真人:, 長内 俊也:, 中山 若樹:, 数又 研:, 寳金 清博:
    • Organizer
      日本脳神経外科学会 第77回学術総会
    • Data Source
      KAKENHI-PROJECT-16K10708
  • [Presentation] 新規人工酸素運搬体“HemoAct”を用いた脳虚血再灌流治療の開発2017

    • Author(s)
      月花正幸 鐙谷武雄 小松晃之 船木亮佑 栗栖宏多 中山若樹 数又研 宝金清博
    • Organizer
      日本脳神経外学会第76回学術総会
    • Data Source
      KAKENHI-PROJECT-16K10708
  • [Presentation] Neuroprotective Therapy for Ischemia-Reperfusion Injury by Hemoglobin-albumin-cluster (HemoAct)2017

    • Author(s)
      Masayuki Gekka, Takeo Abumiya, Teruyuki Komatsu, Ryousuke Funaki, Kota Kurisu, Naoki Nakayama, Ken Kazumata, Hideo Shichinohe and Kiyohiro Houkin
    • Organizer
      International Stroke Conference 2017
    • Place of Presentation
      George R Brown Convention Center, Houston, USA
    • Year and Date
      2017-02-22
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K10708
  • [Presentation] 人工酸素運搬体HemoActを用いた脳虚血再灌流障害に対する脳保護療法2017

    • Author(s)
      月花 正幸, 鐙谷 武雄, 小松 晃之, 船木 亮佑, 栗栖 宏太, 中山 若樹, 数又 研, 宝金 清博
    • Organizer
      第42回日本脳卒中学会学術集会
    • Place of Presentation
      大阪国際会議場、大阪府大阪市
    • Year and Date
      2017-03-16
    • Data Source
      KAKENHI-PROJECT-16K10708
  • [Presentation] A Novel Cerebral Aneurysm Model in Rat with Intraperitoneal BetaAminoPropioNitrilFumarate (Oral Presentation)2016

    • Author(s)
      Yusuke Shimoda, Takuya Moriwaki, Naoki Nakayama, Takeo Abumiya, Ken Kazumata, Hideo Shichinohe, Kiyohiro Houkin
    • Organizer
      International Stroke Conference 2016
    • Place of Presentation
      Los Angeles, USA
    • Year and Date
      2016-02-17
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K10287
  • [Presentation] 大型脳動脈瘤モデルラットの確立へむけて(一般口演)2015

    • Author(s)
      下田祐介 森脇拓也 中山若樹 栗栖宏多 穂刈正昭 七戸秀夫 鐙谷武雄 長内俊也 数又 研 寶金清博
    • Organizer
      第74回 日本脳神経外科学会学術総会
    • Place of Presentation
      ロイトン札幌(北海道-札幌市)
    • Year and Date
      2015-10-14
    • Data Source
      KAKENHI-PROJECT-15K10287
  • [Presentation] Inside Intramural Thrombus Formation with Inflammatory Reactions is Relevant to the Rupture of Cerebral Aneurysms (Oral Presentation)2015

    • Author(s)
      Yusuke Shimoda, Naoki NAKAYAMA, Takeo ABUMIYA, Masaaki HOKARI, Kota KURISU, Hideo SHICHINOHE, Ken KAZUMATA, Kiyohiro HOUKIN
    • Organizer
      83rd AANS Annual Scientific Meeting
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2015-05-02
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K10287
  • 1.  HOUKIN KIYOHIRO (90229146)
    # of Collaborated Projects: 10 results
    # of Collaborated Products: 23 results
  • 2.  NAKAYAMA NAOKI (40421961)
    # of Collaborated Projects: 9 results
    # of Collaborated Products: 15 results
  • 3.  ABUMIYA Takeo (80270726)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 10 results
  • 4.  SHICHINOHE HIDEO (80374479)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 2 results
  • 5.  ITO MASAKI (10399850)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 14 results
  • 6.  Osanai Toshiya (90622788)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 2 results
  • 7.  杉山 拓 (70748863)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 4 results
  • 8.  Hokari Masaaki (30622807)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 9.  小松 晃之 (30298187)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 5 results
  • 10.  川堀 真人 (50399870)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  Yoshimoto Tetsuyuki (50647493)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  SASAKI HIDENAO (80281806)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 13.  森脇 拓也 (30597464)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 14.  黒川 孝幸 (40451439)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  澤村 大輔 (20734750)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  Tha KhinKhin (20451445)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  境 信哉 (30299804)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  内野 晴登 (40775144)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 19.  藤村 幹 (00361098)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 20.  佐藤 典宏 (50360912)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  矢部 一郎 (60372273)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  東海林 菊太郎 (70883164)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 23.  浜内 祝嗣 (70794387)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 24.  SHIMODA Yusuke
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results

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