KAZUMATA Ken 数又研

Researcher Number	60634144
Other IDs
Affiliation (based on the past Project Information) *help	2013 – 2021: 北海道大学, 大学病院, 講師
Review Section/Research Field	Principal Investigator Neurosurgery Except Principal Investigator Neurosurgery / Basic Section 56010:Neurosurgery-related / Basic Section 59010:Rehabilitation science-related
Keywords	Principal Investigator もやもや病 / iPS細胞 / 血管内皮細胞 / 内皮細胞 / バリア機能 / tight junction Except Principal Investigator もやもや病 / 人工酸素運搬体 / 脳梗塞 / 虚血再灌流傷害 … More / RNF213 / 家族性もやもや病 / 表現促進現象 / 遺伝子コピー数多型 / 家族内発症 / コピー数多型 / 脳微小血管 / 細胞老化 / SIRT1 / 脳動脈瘤 / 脳動脈瘤破裂 / 大型脳動脈瘤 / 動物モデル / 抗血小板剤 / ラット / くも膜下出血 / 血行力学的負荷 / 内皮 / ニトロ化合物 / 高血圧 / iPS細胞 / 平滑筋細胞 / 血管平滑筋細胞 / 神経堤 / 神経堤細胞 / 脳保護療法 / 冷却灌流 / 虚血再灌流障害 / 活性酸素 / 脳低温療法 / biomaterial / embolization / Intervention / hydrogel / hypervascular tumor / ハイドロゲル / X線視認性 / 粒子塞栓物質 / ラット系頸動脈投与 / CT / ソフトマターテクノロジー / X線不透過 / 塞栓物質 / ソフトマター / 脳神経疾患 / トランスレーショナルリサーチ / 高分子合成 / 遺伝子変異 / moyamoya病 / 遺伝子多型 / 浅側頭動脈 / ピロリ菌感染 / エクソソーム / ピロリ菌 / 抗酸化物質 / 脳保護作用 / 認知リハビリテーション / トレーニング効果 / resting-state fMRI / computer-based training / 健常者 / 認知機能トレーニング / 脳MRI / 神経心理学的検査 / Moyamoya disease / circulating microRNA / blood biomarker / epigenome / 発症素因 / 病態修飾因子 / 血漿microRNA / エピゲノム / 創始者変異 Less

抗酸化作用を付与した人工酸素運搬体による脳梗塞治療法の開発
- Principal Investigator
  
  鐙谷武雄
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Hokkaido University
Establishment of neurocognitive training to improve frontal lobe function in moyamoya disease
- Principal Investigator
  
  澤村大輔
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59010:Rehabilitation science-related
- Research Institution
  Hokkaido University
Comprehensive validation of circulating microRNA signatures for Moyamoya disease early detection as an epigenome blood biomarker
- Principal Investigator
  
  伊東雅基
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Hokkaido University
Relationship between Chronic inflammation and progression of Moyamoya disease
- Principal Investigator
  
  Hokari Masaaki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Hokkaido University
Development of visible particle embolic material used by new concept hydrogel
- Principal Investigator
  
  Osanai Toshiya
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  Hokkaido University
Development of neuroprotective therapy with selective intra-arterial infusion of cold artificial oxygen carrier
- Principal Investigator
  
  Abumiya Takeo
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  Hokkaido University
Investigation of barrier function of endothelial cells derived from moyamoya disease-specific iPS cellsPrincipal Investigator
- Principal Investigator
  
  KAZUMATA Ken
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  Hokkaido University
Development of an anti-rupture drug treatment method using a novel animal model of easily rupturable large cerebral aneurysm and human clinical specimen
- Principal Investigator
  
  NAKAYAMA Naoki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  Hokkaido University
Induction of smooth muscle cells from iPS cells derived from moyamoya disease patient
- Principal Investigator
  
  Houkin Kiyohiro
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurosurgery
- Research Institution
  Hokkaido University
Genome-wide CNV array analysis in parent-offspring pairs with Moyamoya disease with and without clinical anticipation
- Principal Investigator
  
  Yoshimoto Tetsuyuki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  Hokkaido University
The role of SIRT1 in cellular senescence and characteristics in brain microvascular endothelial cells
- Principal Investigator
  
  HOUKIN Kiyohiro
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurosurgery
- Research Institution
  Hokkaido University

All 2022 2021 2020 2019 2018 2017 2016 2015 2014

All Journal Article Presentation

[Journal Article] Impact of RNF213 founder polymorphism (p.R4810K) on the postoperative development of indirect pial synangiosis after direct/indirect combined revascularization surgery for adult Moyamoya disease2022
- Author(s)
  Ito Masaki、Kawabori Masahito、Sugiyama Taku、Tokairin Kikutaro、Tatezawa Ryota、Uchino Haruto、Kazumata Ken、Houkin Kiyohiro、Fujimura Miki
- Journal Title
  
  Neurosurgical Review
  
  Volume: online ahead of print
- DOI
  10.1007/s10143-022-01749-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03765, KAKENHI-PROJECT-20K09362
[Journal Article] Crossed cerebellar diaschisis as an indicator of severe cerebral hyperperfusion after direct bypass for moyamoya disease2020
- Author(s)
  Uchino Haruto、Kazumata Ken、Ito Masaki、Nakayama Naoki、Kuroda Satoshi、Houkin Kiyohiro
- Journal Title
  
  Neurosurgical Review
  
  Volume: 44 Pages: 599-605
- DOI
  10.1007/s10143-020-01265-8
- NAID
  120006958359
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03765
[Journal Article] Association of cognitive function with cerebral blood flow in children with moyamoya disease2020
- Author(s)
  Kazumata Ken、Tokairin Kikutaro、Sugiyama Taku、Ito Masaki、Uchino Haruto、Osanai Toshiya、Kawabori Masahito、Nakayama Naoki、Houkin Kiyohiro
- Journal Title
  
  Journal of Neurosurgery: Pediatrics
  
  Volume: 25 Pages: 62-68
- DOI
  10.3171/2019.7.peds19312
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03765
[Journal Article] Complication rate, cure rate, and long-term outcomes of microsurgery for intracranial dural arteriovenous fistulae: a multicenter series and systematic review2020
- Author(s)
  Sugiyama Taku、Nakayama Naoki、Ushikoshi Satoshi、Kazumata Ken、Okamoto Michinari、Ito Masaki、Osanai Toshiya、Shimoda Yusuke、Uchida Kazuki、Shimbo Daisuke、Ito Yasuhiro、Asaoka Katsuyuki、Nakamura Toshitaka、Kuroda Satoshi、Houkin Kiyohiro
- Journal Title
  
  Neurosurgical Review
  
  Volume: 44 Pages: 435-450
- DOI
  10.1007/s10143-019-01232-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03765
[Journal Article] Immersive 3-Dimensional Virtual Reality Modeling for Case-Specific Presurgical Discussions in Cerebrovascular Neurosurgery2020
- Author(s)
  Sugiyama Taku、Clapp Tod、Nelson Jordan、Eitel Chad、Motegi Hiroaki、Nakayama Naoki、Sasaki Tsukasa、Tokairin Kikutaro、Ito Masaki、Kazumata Ken、Houkin Kiyohiro
- Journal Title
  
  Operative Neurosurgery
  
  Volume: 20 Pages: 289-299
- DOI
  10.1093/ons/opaa335
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03765
[Journal Article] Vascular Smooth Muscle Cell Derived from IPS Cell of Moyamoya Disease - Comparative Characterization with Endothelial Cell Transcriptome2020
- Author(s)
  Tokairin Kikutaro、Hamauchi Shuji、Ito Masaki、Kazumata Ken、Sugiyama Taku、Nakayama Naoki、Kawabori Masahito、Osanai Toshiya、Houkin Kiyohiro
- Journal Title
  
  Journal of Stroke and Cerebrovascular Diseases
  
  Volume: 29 Pages: 105305-105305
- DOI
  10.1016/j.jstrokecerebrovasdis.2020.105305
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03765
[Journal Article] Brain Structure, Connectivity, and Cognitive Changes Following Revascularization Surgery in Adult Moyamoya Disease2019
- Author(s)
  Kazumata Ken、Tha Khin Khin、Tokairin Kikutaro、Ito Masaki、Uchino Haruto、Kawabori Masahito、Sugiyama Taku
- Journal Title
  
  Neurosurgery
  
  Volume: 85
- DOI
  10.1093/neuros/nyz176
- Data Source
  KAKENHI-PROJECT-19H03765
[Journal Article] Novel Hemoglobin-Based Oxygen Carrier Bound With Albumin Shows Neuroprotection With Possible Antioxidant Effects2018
- Author(s)
  Gekka Masayuki、Abumiya Takeo、Komatsu Teruyuki、Funaki Ryosuke、Kurisu Kota、Shimbo Daisuke、Kawabori Masato、Osanai Toshiya、Nakayama Naoki、Kazumata Ken、Houkin Kiyohiro
- Journal Title
  
  Stroke
  
  Volume: 49 Pages: 1960-1968
- DOI
  10.1161/strokeaha.118.021467
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10708
[Journal Article] Surgical Outcome of Cerebral Aneurysm Clipping Treated with Immunosuppressants: Report of 11 Cases and Review of the Literature2017
- Author(s)
  Hokari M, Nakayama N, Kazumata K, Osanai T, Shichinohe H, Abumiya T, Houkin K.
- Journal Title
  
  Neurologia medico-chirurgica
  
  Volume: 57(3) Issue: 3 Pages: 122-127
- DOI
  10.2176/nmc.oa.2016-0185
- NAID
  130005439797
- ISSN
  0470-8105, 1349-8029
- Language
  English
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K10284, KAKENHI-PROJECT-15K10287
[Journal Article] 表現促進現象を有する家族性もやもや病のCNV解析－研究デザインと進捗報告－2014
- Author(s)
  伊東雅基、宝金清博、佐々木秀直、濱　結香、数又研
- Journal Title
  
  厚生労働科学研究費補助金（難治性疾患克服研究事業）分担研究報告書
  
  Volume: 印刷中
- Data Source
  KAKENHI-PROJECT-25462203
[Presentation] RNF213創始者変異は成人もやもや病複合血行再建術後の間接バイパス路発達に寄与する2021
- Author(s)
  伊東雅基, 川堀真人, 杉山拓, 東海林菊太郎, 舘澤諒大, 内野晴登, 数又研, 寳金清博, 藤村幹
- Organizer
  第80回日本脳神経外科学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03765
[Presentation] 成人もやもや病複合血行再建術後バイパス路発達度におけるRNF213創始者変異の意義2021
- Author(s)
  伊東雅基、川堀真人、杉山拓、東海林菊太郎、舘澤諒大、内野晴登、数又研、寳金清博、藤村幹
- Organizer
  第39回 The Mt. Fuji workshop on CVD
- Data Source
  KAKENHI-PROJECT-19H03765
[Presentation] RNF213創始者変異は成人もやもや病複合血行再建術後の間接バイパス路発達に寄与する2021
- Author(s)
  伊東雅基, 川堀真人, 杉山拓, 東海林菊太郎, 舘澤諒大, 内野晴登, 数又研, 寳金清博, 藤村幹
- Organizer
  第64回　日本脳循環代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03765
[Presentation] 成人もやもや病に対する間接バイパス術に残された課題ーRNF213創始者変異術前検討の意義2021
- Author(s)
  伊東雅基, 川堀真人, 杉山拓, 東海林菊太郎, 舘澤諒大, 内野晴登, 数又研, 寳金清博, 藤村幹
- Organizer
  第51回　日本脳卒中の外科学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03765
[Presentation] 脳虚血再灌流傷害急性期微小循環障害に対するヘモグロビン‐アルブミン複合型人工酸素運搬体HemoActの効果の検討2019
- Author(s)
  [演者] 月花正幸: [共同演者］鐙谷武雄, 小松晃之、舟木亮佑、栗栖宏多、新保大輔、伊藤康裕::, 中山若樹:, 数又研:, 寳金清博:
- Organizer
  第44回日本脳卒中学会学術集会
- Data Source
  KAKENHI-PROJECT-16K10708
[Presentation] もやもや病生体試料バンク構築とエピゲノム血液バイオマーカー探索2019
- Author(s)
  伊東雅基，数又研，寳金清博，他
- Organizer
  第44回日本脳卒中学会総会シンポジウム(Stroke2019)
- Data Source
  KAKENHI-PROJECT-19H03765
[Presentation] もやもや病の脳構造機能解析－慢性虚血によるmicro ischemic injuryの描出2019
- Author(s)
  伊東雅基，数又研，寳金清博，他
- Organizer
  第44回日本脳卒中学会総会シンポジウム(Stroke2019)
- Data Source
  KAKENHI-PROJECT-19H03765
[Presentation] 脳虚血再灌流傷害に対するアルブミン結合型人工酸素運搬体HemoActの脳保護効果の作用機序―微小循環・酸素運搬能改善と抗酸化作用―2018
- Author(s)
  [演者] 鐙谷武雄: [共同演者] 月花正幸, 伊藤康裕:, 川堀真人:, 長内俊也:, 中山若樹:, 数又研:, 寳金清博:
- Organizer
  日本脳神経外科学会第77回学術総会
- Data Source
  KAKENHI-PROJECT-16K10708
[Presentation] 新規人工酸素運搬体“HemoAct”を用いた脳虚血再灌流治療の開発2017
- Author(s)
  月花正幸鐙谷武雄　小松晃之　船木亮佑　栗栖宏多　中山若樹　数又研　宝金清博
- Organizer
  日本脳神経外学会第76回学術総会
- Data Source
  KAKENHI-PROJECT-16K10708
[Presentation] Neuroprotective Therapy for Ischemia-Reperfusion Injury by Hemoglobin-albumin-cluster (HemoAct)2017
- Author(s)
  Masayuki Gekka, Takeo Abumiya, Teruyuki Komatsu, Ryousuke Funaki, Kota Kurisu, Naoki Nakayama, Ken Kazumata, Hideo Shichinohe and Kiyohiro Houkin
- Organizer
  International Stroke Conference 2017
- Place of Presentation
  George R Brown Convention Center, Houston, USA
- Year and Date
  2017-02-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10708
[Presentation] 人工酸素運搬体HemoActを用いた脳虚血再灌流障害に対する脳保護療法2017
- Author(s)
  月花正幸, 鐙谷武雄, 小松晃之, 船木亮佑, 栗栖宏太, 中山若樹, 数又研, 宝金清博
- Organizer
  第42回日本脳卒中学会学術集会
- Place of Presentation
  大阪国際会議場、大阪府大阪市
- Year and Date
  2017-03-16
- Data Source
  KAKENHI-PROJECT-16K10708
[Presentation] A Novel Cerebral Aneurysm Model in Rat with Intraperitoneal BetaAminoPropioNitrilFumarate (Oral Presentation)2016
- Author(s)
  Yusuke Shimoda, Takuya Moriwaki, Naoki Nakayama, Takeo Abumiya, Ken Kazumata, Hideo Shichinohe, Kiyohiro Houkin
- Organizer
  International Stroke Conference 2016
- Place of Presentation
  Los Angeles, USA
- Year and Date
  2016-02-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10287
[Presentation] 大型脳動脈瘤モデルラットの確立へむけて（一般口演）2015
- Author(s)
  下田祐介森脇拓也中山若樹栗栖宏多穂刈正昭七戸秀夫鐙谷武雄長内俊也数又研寶金清博
- Organizer
  第74回日本脳神経外科学会学術総会
- Place of Presentation
  ロイトン札幌（北海道-札幌市）
- Year and Date
  2015-10-14
- Data Source
  KAKENHI-PROJECT-15K10287
[Presentation] Inside Intramural Thrombus Formation with Inflammatory Reactions is Relevant to the Rupture of Cerebral Aneurysms (Oral Presentation)2015
- Author(s)
  Yusuke Shimoda, Naoki NAKAYAMA, Takeo ABUMIYA, Masaaki HOKARI, Kota KURISU, Hideo SHICHINOHE, Ken KAZUMATA, Kiyohiro HOUKIN
- Organizer
  83ｒd AANS Annual Scientific Meeting
- Place of Presentation
  Washington DC, USA
- Year and Date
  2015-05-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10287

1. HOUKIN KIYOHIRO (90229146)

# of Collaborated Projects: 10 results

# of Collaborated Products: 23 results
2. NAKAYAMA NAOKI (40421961)

# of Collaborated Projects: 9 results

# of Collaborated Products: 15 results
3. ABUMIYA Takeo (80270726)

# of Collaborated Projects: 7 results

# of Collaborated Products: 10 results
4. SHICHINOHE HIDEO (80374479)

# of Collaborated Projects: 5 results

# of Collaborated Products: 2 results
5. ITO MASAKI (10399850)

# of Collaborated Projects: 3 results

# of Collaborated Products: 14 results
6. Osanai Toshiya (90622788)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
7. 杉山拓 (70748863)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
8. Hokari Masaaki (30622807)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
9. 小松晃之 (30298187)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
10. 川堀真人 (50399870)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. Yoshimoto Tetsuyuki (50647493)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. SASAKI HIDENAO (80281806)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. 森脇拓也 (30597464)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
14. 黒川孝幸 (40451439)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 澤村大輔 (20734750)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. Tha KhinKhin (20451445)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 境信哉 (30299804)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 内野晴登 (40775144)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
19. 藤村幹 (00361098)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
20. 佐藤典宏 (50360912)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 矢部一郎 (60372273)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 東海林菊太郎 (70883164)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
23. 浜内祝嗣 (70794387)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
24. SHIMODA Yusuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results

KAZUMATA Ken 数又 研

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Investigation of barrier function of endothelial cells derived from moyamoya disease-specific iPS cellsPrincipal Investigator

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[Journal Article] Impact of RNF213 founder polymorphism (p.R4810K) on the postoperative development of indirect pial synangiosis after direct/indirect combined revascularization surgery for adult Moyamoya disease2022

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[Journal Article] Crossed cerebellar diaschisis as an indicator of severe cerebral hyperperfusion after direct bypass for moyamoya disease2020

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NAID

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[Journal Article] Association of cognitive function with cerebral blood flow in children with moyamoya disease2020

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[Journal Article] Complication rate, cure rate, and long-term outcomes of microsurgery for intracranial dural arteriovenous fistulae: a multicenter series and systematic review2020

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KAZUMATA Ken 数又研

[Journal Article] 表現促進現象を有する家族性もやもや病のCNV解析－研究デザインと進捗報告－2014