YAMADA Yasushi 山田靖

Researcher Number	60646652
Affiliation (based on the past Project Information) *help	2016 – 2023: 信州大学, 学術研究院医学系(医学部附属病院), 助教 2015: 信州大学, 医学部附属病院, 助教(特定雇用) 2015: 信州大学, 学術研究院医学系(医学部附属病院), 助教 2014: 信州大学, 医学部附属病院, 助教(診療) 2013: 信州大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Obstetrics and gynecology / Basic Section 56040:Obstetrics and gynecology-related Except Principal Investigator Obstetrics and gynecology / Basic Section 56040:Obstetrics and gynecology-related
Keywords	Principal Investigator 子宮体癌 / 分子標的薬 / 子宮内膜癌 / サイクリンA / 婦人科腫瘍学 / 粘液性癌 / 明細胞癌 / Oグリカン鎖 / 浸潤能 / 遊走能 … More / O-グリカン鎖 / 卵巣癌 / C2GnT1 / 活性酸素種 / 卵巣類内膜腺癌 / l卵巣明細胞腺癌 / 卵巣子宮内膜症性嚢胞 / xCT / CD44 variant / グルタチオン / 抗癌剤耐性 / 酸化ストレス耐性 / 卵巣明細胞腺癌 / lipocalin2 / 酸化ストレス / ｘCT / CD44v / ROS / 子宮内膜症性嚢胞 … More Except Principal Investigator 子宮内膜癌 / 鉄イオン / 卵巣明細胞癌 / salinomycin / 鉄運搬 / CD133 / CD44 / Sphere形成能 / 抗がん剤耐性 / Lipocalin2 / 合成LCN2 / CD44v / 酸化ストレス耐性 / 鉄運搬タンパク / 癌幹細胞性 / LCN2 / 癌化 / ミスマッチ修復以上 / マイクロサテライト不安定性 / 炎症性サイトカイン / ミスマッチ修復異常 / 卵巣子宮内膜症性嚢胞 / 卵巣癌 / 子宮内膜症 / TNFα / サイトカイン / ミスマッチ修復 / 造腫瘍能 / マイクロアレイ / 癌幹細胞マーカー / 抗癌剤耐性 / lipocalin2 Less

Elucidation of the Mechanism of Action of Newly Synthesized Antitumor Compounds Against Endometrial CancerPrincipal Investigator
- Principal Investigator
  
  Yamada Yasushi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Shinshu University
Elucidation of the function of LCN2 in stem cell maintenance of gynecologic cancer cells
- Principal Investigator
  
  Miyamoto Tsutomu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Shinshu University
The expression and function of C2GnT1 in ovarian carcinoma cellsPrincipal Investigator
- Principal Investigator
  
  Yamada Yasushi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Shinshu University
Roles of cytokine and mismatch repair abnormality in the carcinogenetic process of ovarian endometriosis
- Principal Investigator
  
  Oka Kenji
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Shinshu University
Study for development of the therapy targeting the novel oncogene lipocalin2 in endometrial carcinoma
- Principal Investigator
  
  MIYAMOTO Tsutomu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Shinshu University
Study for the expression and function of lipocalin 2 in the development of ovarian carcinoma arising from endometriosisPrincipal Investigator
- Principal Investigator
  
  YAMADA Yasushi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Shinshu University

All 2017 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Mutation analysis by whole exome sequencing of endometrial hyperplasia and carcinoma in one patient: Abnormalities of polymerase epsilon and the phosphatidylinositol-3 kinase pathway2017
- Author(s)
  Miyamoto Tsutomu、Ando Hirofumi、Asaka Ryoichi、Yamada Yasushi、Shiozawa Tanri
- Journal Title
  
  Journal of Obstetrics and Gynaecology Research
  
  Volume: 44 Issue: 1 Pages: 179-183
- DOI
  10.1111/jog.13459
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10710
[Journal Article] Overexpression of SIRT1 is Associated With Poor Outcomes in Patients With Ovarian Carcinoma.2016
- Author(s)
  Mvunta DH, Miyamoto T, Asaka R, Yamada Y, Ando H, Higuchi S, Ida K, Kashima H, Shiozawa T.
- Journal Title
  
  Appl Immunohistochem Mol Morphol
  
  Volume: Feb 9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10710
[Journal Article] Lipocalin 2 Enhances Migration and Resistance against Cisplatin in Endometrial Carcinoma Cells.2016
- Author(s)
  Miyamoto T, Kashima H, Yamada Y, Kobara H, Asaka R, Ando H, Higuchi S, Ida K, Mvunta DH, Shiozawa T
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 5 Pages: e0155220-e0155220
- DOI
  10.1371/journal.pone.0155220
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10710, KAKENHI-PROJECT-15K10712, KAKENHI-PROJECT-25293339
[Journal Article] Lipocalin 2 attenuates iron-related oxidative stress and prolongs the survival of ovarian clear cell carcinoma cells by up-regulating the CD44 variant.2016
- Author(s)
  Yamada Y, Miyamoto T, Kashima H, Kobara H, Asaka R, Ando H, Higuchi S, Ida K, Shiozawa T.
- Journal Title
  
  Free Radic Res.
  
  Volume: 50 Issue: 4 Pages: 414-25
- DOI
  10.3109/10715762.2015.1134795
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10710, KAKENHI-PROJECT-15K10712, KAKENHI-PROJECT-25861484, KAKENHI-PROJECT-25293339
[Journal Article] Sirtuin 1 promotes the growth and cisplatin resistance of endometrial carcinoma cells: a novel therapeutic target.2015
- Author(s)
  Asaka R, Miyamoto T, Yamada Y, Ando H, Mvunta DH, Kobara H, Shiozawa T
- Journal Title
  
  Lab Invest
  
  Volume: 95 Issue: 12 Pages: 1363-73
- DOI
  10.1038/labinvest.2015.119
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10710, KAKENHI-PROJECT-15K10711, KAKENHI-PROJECT-15K10712, KAKENHI-PROJECT-25293339
[Journal Article] Polypoid endometriosis of the ovary mimicking ovarian carcinoma dissemination: a case report and literature review2014
- Author(s)
  4.Yamada Y, Miyamoto T, Horiuchi A, Ohya A, Shiozawa T
- Journal Title
  
  J Obstet Gynaecol Res
  
  Volume: 40 Issue: 5 Pages: 1426-30
- DOI
  10.1111/jog.12358
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293339, KAKENHI-PROJECT-25293340, KAKENHI-PROJECT-25670699, KAKENHI-PROJECT-25861484
[Journal Article] Lipocalin2 enhances the matrix metalloproteinase-9 activity and invasion of extravillous trophoblasts under hypoxia.2013
- Author(s)
  Kobara H, Miyamoto T, Suzuki A, Asaka R, Yamada Y, Ishikawa K, Kikuchi N, Ohira S, Shiozawa T.
- Journal Title
  
  Placenta
  
  Volume: 34(11) Issue: 11 Pages: 1036-43
- DOI
  10.1016/j.placenta.2013.08.004
- Data Source
  KAKENHI-PROJECT-23592442, KAKENHI-PROJECT-24659724, KAKENHI-PROJECT-24659725, KAKENHI-PROJECT-24791696, KAKENHI-PROJECT-25293339, KAKENHI-PROJECT-25293340, KAKENHI-PROJECT-25670698, KAKENHI-PROJECT-25861483, KAKENHI-PROJECT-25861484
[Journal Article] Immunohistochemical expression of core 2 β1,6-N-acetylglucosaminyl transferase 1 (C2GnT1) in endometrioid-type endometrial carcinoma: a novel potential prognostic factor.2013
- Author(s)
  Miyamoto T
- Journal Title
  
  Histopathology
  
  Volume: Feb 9 [Epub ahead of print] Issue: 7 Pages: 986-93
- DOI
  10.1111/his.12107
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390310, KAKENHI-PROJECT-23592442, KAKENHI-PROJECT-24659724, KAKENHI-PROJECT-24659725, KAKENHI-PROJECT-24791696, KAKENHI-PROJECT-25293339, KAKENHI-PROJECT-25293340, KAKENHI-PROJECT-25861483
[Presentation] Lipocalin2 enhances the tolerance against oxidative stress of clear cell carcinoma of the ovary by up-regulating the CD44 variant in vitro2015
- Author(s)
  Yasushi Yamada, Tsutomu Miyamoto, Hiroyasu Kashima, Hisanori Kobara, Ryoichi Asaka, Hirofumi Ando, Shotaro Higuchi, Kosuke Ida and Tanri Shiozawa.
- Organizer
  The 4th Birnnial Meeting of ASGO
- Place of Presentation
  Lotte Hotel, Seoul, Korea
- Year and Date
  2015-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25861484
[Presentation] Lipocalin2は卵巣明細胞腺癌細胞の酸化ストレス耐性を増強する2015
- Author(s)
  山田靖、宮本強、小原久典、浅香亮一、安藤大史、樋口正太郎、鹿島大靖、塩沢丹里
- Organizer
  第67回日本産科婦人科学会学術講演会
- Place of Presentation
  神奈川県横浜市　パシフィコ横浜
- Year and Date
  2015-04-09
- Data Source
  KAKENHI-PROJECT-25861484
[Presentation] Lipocalin2は子宮内膜癌において新規癌遺伝子として作用する2013
- Author(s)
  宮本　強、山田　靖、浅香亮一、安藤大史、石川香織、小原久典、鈴木昭久、塩沢丹里
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25293339
[Presentation] 卵巣明細胞腺癌におけるLipocalin2発現は遊走・浸潤能を亢進する2013
- Author(s)
  山田　靖、宮本　強、小原久典、浅香亮一、安藤大史、石川香織、塩沢丹里
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25861484
[Presentation] 鉄運搬に関わるLipocalin2は、子宮内膜癌で新規がん遺伝子として機能する2013
- Author(s)
  宮本　強、浅香亮一、山田　靖、小原久典、石川香織、鈴木昭久、塩沢丹里
- Organizer
  第65回日本産科婦人科学会学術講演会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-25293339
[Presentation] cDNA発現ライブラリーの機能的スクリーニングによる卵巣明細胞腺癌原因遺伝子の探索2013
- Author(s)
  山田　靖、宮本　強、鈴木昭久、浅香亮一、石川香織、安藤大史、小原久典、鹿島大靖、塩沢丹里
- Organizer
  第12回日本婦人科がん分子標的研究会学術集会
- Place of Presentation
  奈良
- Data Source
  KAKENHI-PROJECT-25861484
[Presentation] Lipocalin2 accelerates tumor growth and functions as a novel onvogene in endometrial carcinoma cell.2013
- Author(s)
  Miyamoto T,Yamada Y,Kobara H,Asaka R,Ando H,Ishikawa K,David Hamisi Mvunta,Suzuki A,Shiozawa T.
- Organizer
  第3回アジア婦人科腫瘍学会・第55回日本婦人科腫瘍学会学術講演会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-25293339
[Presentation] Lipocalin2 enhances migration, invasion and tolerance against oxidative stress of ovarian clear cell carcinoma cells.2013
- Author(s)
  Yamada Y,Miyamoto T, Kobara H,Asaka R, Ando H,Ishikawa K, David Hamisi Mvunta, Shiozawa T.
- Organizer
  第3回アジア婦人科腫瘍学会・第55回日本婦人科腫瘍学会学術講演会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-25861484
[Presentation] 卵巣癌および子宮内膜症におけるLipocalin2発現の免疫組織化学的検討2013
- Author(s)
  山田　靖、宮本　強、浅香亮一、石川香織、小原久典、鈴木昭久、塩沢丹里
- Organizer
  第65回日本産科婦人科学会学術講演会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-25861484
[Presentation] Lipocalin2,an iron transporter,functions as a novel oncogene and enhances the proliferation and survival of endometrial carcinoma cell
- Author(s)
  Miyamoto T,Asaka R, Yamada Y,Ishikawa k, Kobara H,Suzuki A,Shiozawa T.
- Organizer
  American Assosiation for Cancer Research Annual Meeting 2013
- Place of Presentation
  ワシントンD.C（アメリカ）
- Data Source
  KAKENHI-PROJECT-25293339

1. MIYAMOTO Tsutomu (70418721)

# of Collaborated Projects: 4 results

# of Collaborated Products: 10 results
2. SHIOZAWA Tanri (20235493)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
3. 竹内穂高 (30816351)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. KOBARA Hisanori (30598818)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. Oka Kenji (40345749)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 鹿島大靖 (70464089)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SUZUKI Akihisa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YAMADA Yasushi 山田 靖

Research Projects

Research Products

Co-Researchers

Elucidation of the Mechanism of Action of Newly Synthesized Antitumor Compounds Against Endometrial CancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the function of LCN2 in stem cell maintenance of gynecologic cancer cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The expression and function of C2GnT1 in ovarian carcinoma cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Roles of cytokine and mismatch repair abnormality in the carcinogenetic process of ovarian endometriosis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study for development of the therapy targeting the novel oncogene lipocalin2 in endometrial carcinoma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study for the expression and function of lipocalin 2 in the development of ovarian carcinoma arising from endometriosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Mutation analysis by whole exome sequencing of endometrial hyperplasia and carcinoma in one patient: Abnormalities of polymerase epsilon and the phosphatidylinositol-3 kinase pathway2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Overexpression of SIRT1 is Associated With Poor Outcomes in Patients With Ovarian Carcinoma.2016

Author(s)

Journal Title

Data Source

[Journal Article] Lipocalin 2 Enhances Migration and Resistance against Cisplatin in Endometrial Carcinoma Cells.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lipocalin 2 attenuates iron-related oxidative stress and prolongs the survival of ovarian clear cell carcinoma cells by up-regulating the CD44 variant.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sirtuin 1 promotes the growth and cisplatin resistance of endometrial carcinoma cells: a novel therapeutic target.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Polypoid endometriosis of the ovary mimicking ovarian carcinoma dissemination: a case report and literature review2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lipocalin2 enhances the matrix metalloproteinase-9 activity and invasion of extravillous trophoblasts under hypoxia.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Immunohistochemical expression of core 2 β1,6-N-acetylglucosaminyl transferase 1 (C2GnT1) in endometrioid-type endometrial carcinoma: a novel potential prognostic factor.2013

Author(s)

Journal Title

DOI

Data Source

[Presentation] Lipocalin2 enhances the tolerance against oxidative stress of clear cell carcinoma of the ovary by up-regulating the CD44 variant in vitro2015

YAMADA Yasushi 山田靖