OHASHI KADOAKI 大橋圭明

… Alternative Names

Ohashi Kadoaki 大橋圭明

Less

Researcher Number	60729193
Other IDs	https://orcid.org/0000-0002-5180-3933
Affiliation (Current)	2024: 岡山大学, 大学病院, 准教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 岡山大学, 大学病院, 准教授 2020 – 2022: 岡山大学, 大学病院, 研究准教授 2017 – 2019: 岡山大学, 大学病院, 講師 2014 – 2016: 岡山大学, 大学病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 53030:Respiratory medicine-related / Respiratory organ internal medicine / Medium-sized Section 53:Organ-based internal medicine and related fields Except Principal Investigator Basic Section 55040:Respiratory surgery-related / Basic Section 53030:Respiratory medicine-related / Respiratory organ internal medicine
Keywords	Principal Investigator EGFR変異 / 肺癌 / 非小細胞肺癌 / 腫瘍微小環境 / 腫瘍免疫 / 非小細胞癌 / セツキシマブ / 腫瘍免疫療法 / EGFR－TKI / EGFR肺癌 … More / Oct4 / 2型肺胞上皮細胞 / Oct４ / 癌幹細胞 / 遺伝子改変マウス / persisterがん細胞 / persister / VEGR2 / PD-1 / 臨床呼吸器学 / AZD9291 / EGFR / 呼吸器の腫瘍 / ベバシズマブ / オシメルチニブ / EGFR　T790M / ベバシツズマブ / アファチニブ / EGFRT790M … More Except Principal Investigator 肺癌 / 腫瘍免疫療法 / 腫瘍免疫 / PD-1 / 非小細胞肺癌 / 呼吸器の腫瘍 / 臨床呼吸器学 / EGFR変異 / TLS / 腫瘍浸潤B細胞 / 空間マルチオミクス解析 / T細胞 / 腫瘍浸潤リンパ球 / ドライバー遺伝子 / 精密医療 / パスウェイ / 肺腺がん / EGFR遺伝子変異 / 併用療法 / 耐性獲得メカニズム / ドラッグリポジショニング / ドライバー遺伝子変異 / VEGF受容体阻害薬 / PD-1阻害薬 / EGFR-TKI / EGFR / 耐性 / パスウェイ解析 / 遺伝子発現データ解析 / バイオインフォマティクス / Ad- SGE-REIC / 遺伝子治療 / ウィルスベクター / ＥＧＦＲ変異 / 肺腺癌 / 抗腫瘍免疫療法 / REIC / レーザーマイクロダイセクション / Kinase遺伝子発現解析 / 次世代シーケンサー / 特発性肺線維症 / 肺線維症 / 内科 / EGFR肺癌 / 肺癌幹細胞 / 非小細胞癌 / 遺伝子改変マウスモデル / 癌幹細胞 Less

Two aspects of tumor-infiltrating lymphocytes in lung cancer
- Principal Investigator
  
  冨樫庸介
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Okayama University
Functional analysis of TLS, tumor-infiltrating B-cell, by spatial multi-omics profiling and its application to tumor immunotherapy
- Principal Investigator
  
  冨田秀太
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Okayama University
Oct4陽性肺癌幹細胞マウスモデルの樹立と癌幹細胞を根絶する革新的治療法の開発Principal Investigator
- Principal Investigator
  
  大橋圭明
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Okayama University
persister癌細胞と腫瘍微小環境の双方を標的とした革新的腫瘍免疫療法の開発Principal Investigator
- Principal Investigator
  
  大橋圭明
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Okayama University
Development of next-generation precision medicine targeting the pathways on which driver gene mutation-positive lung cancer depends
- Principal Investigator
  
  Tomida Shuta
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Okayama University
Development of a curative treatment strategy for lung cancer using the persister cancer cell mouse model.Principal Investigator
- Principal Investigator
  
  Ohashi Kadoaki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Okayama University
Development of innovative immunotherapy for lung cancer using tumor immune-activating gene REIC
- Principal Investigator
  
  Katsuyuki Kiura
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Okayama University
Comprehensive analysis of druggable tyrosine kinase in idiopathic interstitial pneumonia
- Principal Investigator
  
  Kiura Katsuyuiki
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Okayama University
In vivo efficacy of triplet therapy with osimertinib, cetuximab and bevacizumab for lung cancer cells harboring EGFR T790MPrincipal Investigator
- Principal Investigator
  
  Ohashi Kadoaki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Okayama University
Next generation lung cancer mice model for conquering cancer stem
- Principal Investigator
  
  Kiura Katsuyuki
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Okayama University
The impact of bevacizumab on EGFR-TKI and anti-EGFR antibodyPrincipal Investigator
- Principal Investigator
  
  Ohashi Kadoaki
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Okayama University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Patent

[Journal Article] PD-1 blockade augments CD8+ T cell dependent antitumor immunity triggered by Ad-SGE-REIC in Egfr-mutant lung cancer.2023
- Author(s)
  Nakasuka T, Ohashi K, Nishii K, Hirabae A, Okawa S, Tomonobu N, Takada K, Ando C, Watanabe H, Makimoto G, Ninomiya K, Fujii M, Kubo T, Ichihara E, Hotta K, Tabata M, Kumon H, Maeda Y, Kiura K.
- Journal Title
  
  Lung Cancer.
  
  Volume: 178 Pages: 1-10
- DOI
  10.1016/j.lungcan.2023.01.018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19529, KAKENHI-PROJECT-19K23930, KAKENHI-PROJECT-22K20793, KAKENHI-PROJECT-19H03667, KAKENHI-PROJECT-23K24339
[Journal Article] CD8+ T-cell responses are boosted by dual PD-1/VEGFR2 blockade after EGFR inhibition in Egfrmutant lung cancer.2022
- Author(s)
  Nishii K, Ohashi K, Tomida S, Nakasuka T, Hirabae A,Okawa S, Nishimura J, Higo H, Watanabe H, Kano H, Ando C, Makimoto G, Ninomiya K, Kato Y, Kubo T, Ichihara E, Hotta K, Tabata M, Toyooka S, Udono H, Maeda Y, Kiura K.
- Journal Title
  
  Cancer Immunol Res.
  
  Volume: 10 Issue: 9 Pages: 1111-1126
- DOI
  10.1158/2326-6066.cir-21-0751
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19409, KAKENHI-PROJECT-22K19529, KAKENHI-PROJECT-18H04033, KAKENHI-PROJECT-19H03667, KAKENHI-PROJECT-20H03771, KAKENHI-PROJECT-23K24339
[Journal Article] Triple therapy with osimertinib, bevacizumab and cetuximab in EGFR-mutant lung cancer with HIF-1α/TGF-α expression2021
- Author(s)
  Nishii K, Ohashi K, Watanabe H, Makimoto G, Nakasuka T, Higo H, Ninomiya K, Kato Y, Kubo T, Rai K, Ichihara E, Hotta K, Tabata M, Maeda Y, Kiura K.
- Journal Title
  
  Mol Cancer Ther .
  
  Volume: 22(3) Issue: 9 Pages: 639-639
- DOI
  10.1158/1535-7163.mct-20-0965
- NAID
  120007185583
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03667
[Journal Article] Phase 1/2 study of alectinib in RET-rearranged previously-treated non-small cell lung cancer (ALL-RET)2021
- Author(s)
  Takeuchi Shinji、Yanagitani Noriko、Seto Takashi、Hattori Yoshihiro、Ohashi Kadoaki、Morise Masahiro、Matsumoto Shingo、Yoh Kiyotaka、Goto Koichi、Nishio Makoto、Takahara Shizuko、Kawakami Takahiro、Imai Yasuhito、Yoshimura Kenichi、Tanimoto Azusa、Nishiyama Akihiro、Murayama Toshinori、Yano Seiji
- Journal Title
  
  Translational Lung Cancer Research
  
  Volume: 10 Issue: 1 Pages: 314-325
- DOI
  10.21037/tlcr-20-549
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08516, KAKENHI-PROJECT-19K08625, KAKENHI-PROJECT-19K07910
[Journal Article] Capmatinib in Japanese patients with MET exon 14 skipping-mutated or MET-amplified advanced NSCLC: GEOMETRY mono-1 study2021
- Author(s)
  Seto T, Ohashi K, Sugawara S, Nishio M, Takeda M, Aoe K, Moizumi S, Nomura S, Tajima T, Hida T.
- Journal Title
  
  Cancer Sci.
  
  Volume: 112(4) Issue: 4 Pages: 1556-1566
- DOI
  10.1111/cas.14826
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08625
[Journal Article] Triple therapy with osimertinib, bevacizumab and cetuximab in EGFR-mutant lung cancer with HIF-1α/TGF-α expression2021
- Author(s)
  Nishii K, Ohashi K, Watanabe H, Makimoto G, Nakasuka T, Higo H, Ninomiya K, Kato Y, Kubo T, Rai K, Ichihara E, Hotta K, Tabata M, Maeda Y, Kiura K.
- Journal Title
  
  Oncol Lett .
  
  Volume: 22(3) Issue: 3 Pages: 639-639
- DOI
  10.3892/ol.2021.12900
- NAID
  120007185583
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08625
[Journal Article] Survival of chemo-naive patients with EGFR mutation-positive advanced non-small cell lung cancer after treatment with afatinib and bevacizumab: updates from the Okayama Lung Cancer Study Group Trial 14042021
- Author(s)
  Ninomiya T, Nogami N, Kozuki T, Harada D, Kubo T, Ohashi K, Ichihara E, Kuyama S, Kudo K, Bessho A, Sakugawa M, Fujimoto N, Aoe K, Minami D, Sugimoto K, Ochi N, Takigawa N, Hotta K, Maeda Y, Kiura K.
- Journal Title
  
  Jpn J Clin Oncol .
  
  Volume: 51(8) Issue: 8 Pages: 1269-1276
- DOI
  10.1093/jjco/hyab084
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08625, KAKENHI-PROJECT-19H03667
[Journal Article] Comparison of bronchoscopy and computed tomography-guided needle biopsy for re-biopsy in non-small cell lung cancer patients2021
- Author(s)
  Kano H, Kubo T, Ninomiya K, Ichihara E, Ohashi K, Rai K, Hotta K, Tabata M, Hiraki T, Kanazawa S, Maeda Y, Kiura K.
- Journal Title
  
  Respir Investig .
  
  Volume: 59(2) Issue: 2 Pages: 240-246
- DOI
  10.1016/j.resinv.2020.12.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08625
[Journal Article] A novel osimertinib-resistant human lung adenocarcinoma cell line harbouring mutant EGFR and activated IGF1R2021
- Author(s)
  Makimoto G, Ninomiya K, Kubo T, Sunami R, Kato Y, Ichihara E, Ohashi K, Rai K, Hotta K, Tabata M, Maeda Y, Kiura K.
- Journal Title
  
  Jpn J Clin Oncol.
  
  Volume: 51 Issue: 6 Pages: 956-965
- DOI
  10.1093/jjco/hyab048
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08625
[Journal Article] VEGFR2 blockade augments the effects of tyrosine kinase inhibitors by inhibiting angiogenesis and oncogenic signaling in oncogene-driven non-small-cell lung cancers2021
- Author(s)
  Watanabe H, Ichihara E, Kayatani H, Makimoto G, Ninomiya K, Nishii K, Higo H, Ando C, Okawa S, Nakasuka T, Kano H, Hara N, Hirabae A, Kato Y, Ninomiya T, Kubo T, Rai K, Ohashi K, Hotta K, Tabata M, Maeda Y, Kiura K.
- Journal Title
  
  Cancer Sci
  
  Volume: 112(5) Issue: 5 Pages: 1853-1864
- DOI
  10.1111/cas.14801
- NAID
  120007008532
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03667
[Journal Article] MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I2021
- Author(s)
  Bragelmann J, Lorenz C, Borchmann S, Nishii K, Wegner J, Meder L, Ostendorp J, Ast DF, Heimsoeth A, Nakasuka T, Hirabae A, Okawa S, et al, and Ohashi K, Schlee M, Sos ML.
- Journal Title
  
  Nat Commun.
  
  Volume: 12 Issue: 1 Pages: 5505-5505
- DOI
  10.1038/s41467-021-25728-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08625
[Journal Article] A case of dramatic reduction in cancer-associated thrombus following initiation of pembrolizumab in patient with a poor performance status and PD-L1+ lung adenocarcinoma harboring CCDC6-RET fusion gene and NF1/TP53 mutations.2021
- Author(s)
  Nakasuka T, Ohashi K, Watanabe H, Kubo T, Matsumoto S, Goto K, Hotta K, Maeda Y, Kiura K.
- Journal Title
  
  Lung Cancer.
  
  Volume: 156 Pages: 1-4
- DOI
  10.1016/j.lungcan.2021.03.022
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08625, KAKENHI-PROJECT-19H03667
[Journal Article] Detection of epidermal growth factor receptor mutations in exhaled breath condensate using droplet digital polymerase chain reaction.2020
- Author(s)
  Nishii K, Ohashi K, Tamura T, Ninomiya K, Matsubara T, Senoo S, Kano H, Watanabe H, Oda N, Makimoto G, Higo H, Kato Y, Ninomiya T, Kubo T, Yamamoto H, Tomida S, Hotta K, Tabata M, Toyooka S, Maeda Y, Kiura K.
- Journal Title
  
  Oncol Lett
  
  Volume: 6 Issue: 6 Pages: 393-393
- DOI
  10.3892/ol.2020.12256
- NAID
  120007029912
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08625, KAKENHI-PROJECT-19H03667
[Journal Article] Impact of HER2 expression on EGFR-TKI treatment outcomes in lung tumors harboring EGFR mutations: A HER2-CS study subset analysis.2020
- Author(s)
  Ohashi K, Ninomiya K, Yoshioka H, Bessho A, Shibayama T, Aoe K, Ishikawa N, Kozuki T, Kawai H, Kuyama S, Miyoshi S, Fujitaka K, Obata H, Tsubata Y, Awaya Y, Inoue M, Inoue K, Horita N, Yanai H, Hotta K, Kiura K.
- Journal Title
  
  Lung Cancer.
  
  Volume: 150 Pages: 83-89
- DOI
  10.1016/j.lungcan.2020.09.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08625, KAKENHI-PROJECT-19H03667
[Journal Article] Share Beneficial effect of erlotinib and trastuzumab emtansine combination in lung tumors harboring EGFR mutations.2020
- Author(s)
  Kayatani H, Ohashi K, Ninomiya K, Makimoto G, Nishii K, Higo H, Watanabe H, Kano H, Kato Y, Ninomiya T, Kubo T, Rai K, Ichihara E, Hotta K, Tabata M, Maeda Y, Kiura K.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 532(3) Issue: 3 Pages: 341-346
- DOI
  10.1016/j.bbrc.2020.07.055
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08625, KAKENHI-PROJECT-19H03667
[Journal Article] Successful Re-administration of Osimertinib in Osimertinib-induced Interstitial Lung Disease with an Organizing Pneumonia Pattern: A Case Report and Literature Review2020
- Author(s)
  Itano J, Higo H, Ohashi K, Makimoto G, Nishii K, Hotta K, Miyahara N, Maeda Y, Kiura K.
- Journal Title
  
  Intern. Med.
  
  Volume: 59 Issue: 6 Pages: 823-828
- DOI
  10.2169/internalmedicine.3689-19
- NAID
  130007808796
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2020-03-15
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08625, KAKENHI-PROJECT-19H03667
[Journal Article] A Long-term Response to Nivolumab in a Case of PD-L1-negative Lung Adenocarcinoma with an <i>EGFR</i> Mutation and Surrounding PD-L1-positive Tumor-associated Macrophages2019
- Author(s)
  Watanabe H, Ohashi K, Nishii K, Seike K, Makimoto G, Hotta K, Maeda Y, Kiura K.
- Journal Title
  
  Intern. Med.
  
  Volume: 58 Issue: 20 Pages: 3033-3037
- DOI
  10.2169/internalmedicine.2875-19
- NAID
  130007728791
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2019-10-15
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08625
[Journal Article] EGFR-TKI acquired resistance in lung cancers harboring EGFR mutations in immunocompetent C57BL/6J mice.2019
- Author(s)
  Higo H, Ohashi K, Makimoto G, Nishii K, Kudo K, Kayatani H, Watanabe H, Kano H, Ninomiya K, Hotta K, Maeda Y, Kiura K.
- Journal Title
  
  Lung Cancer
  
  Volume: 136 Pages: 86-93
- DOI
  10.1016/j.lungcan.2019.08.019
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08625, KAKENHI-PROJECT-19H03667
[Journal Article] Beneficial Effect of Osimertinib Readministration in Non-small-cell Lung Cancer Harboring an Epidermal Growth Factor Receptor (<i>EGFR</i>) Mutation with a History of Acquired Resistance to Osimertinib2019
- Author(s)
  Makimoto G, Ohashi K, Senoo S, Hotta K, Maeda Y, Kiura K
- Journal Title
  
  Intern. Med.
  
  Volume: 58 Issue: 11 Pages: 1625-1627
- DOI
  10.2169/internalmedicine.2152-18
- NAID
  130007658147
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2019-06-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K19454, KAKENHI-PROJECT-19K08625
[Journal Article] Rapid Acquisition of Alectinib Resistance in ALK-Positive Lung Cancer With High Tumor Mutation Burden.2019
- Author(s)
  Makimoto G, Ohashi K, Tomida S, Nishii K, Matsubara T, Kayatani H, Higo H, Ninomiya K, Sato A, Watanabe H, Kano H, Ninomiya T, Kubo T, Rai K, Ichihara E, Hotta K, Tabata M, Toyooka S, Takata M, Maeda Y, Kiura K.
- Journal Title
  
  J Thorac Oncol.
  
  Volume: 11 Issue: 11 Pages: 2009-2018
- DOI
  10.1016/j.jtho.2019.07.017
- NAID
  120006871852
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08625, KAKENHI-PROJECT-17K10784, KAKENHI-PROJECT-18K15925
[Journal Article] MET or NRAS amplification is an acquired resistance mechanism to the third-generation EGFR inhibitor naquotinib2018
- Author(s)
  Ninomiya Kiichiro、Ohashi Kadoaki、Makimoto Go、Tomida Shuta、Higo Hisao、Kayatani Hiroe、Ninomiya Takashi、Kubo Toshio、Ichihara Eiki、Hotta Katsuyuki、Tabata Masahiro、Maeda Yoshinobu、Kiura Katsuyuki
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 1955-1955
- DOI
  10.1038/s41598-018-20326-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10784, KAKENHI-PROJECT-16K19454, KAKENHI-PUBLICLY-16H01574, KAKENHI-PROJECT-15H04830, KAKENHI-PROJECT-16K15458, KAKENHI-PROJECT-18K15925
[Journal Article] Combined effect of cabozantinib and gefitinib in crizotinib-resistant lung tumors harboring ROS1 fusions2018
- Author(s)
  Kato Yuka、Ninomiya Kiichiro、Ohashi Kadoaki、Tomida Shuta、Makimoto Go、Watanabe Hiromi、Kudo Kenichiro、Matsumoto Shingo、Umemura Shigeki、Goto Koichi、Ichihara Eiki、Ninomiya Takashi、Kubo Toshio、Sato Akiko、Hotta Katsuyuki、Tabata Masahiro、Toyooka Shinichi、Maeda Yoshinobu、Kiura Katsuyuki
- Journal Title
  
  Cancer Science
  
  Volume: 109 Issue: 10 Pages: 3149-3158
- DOI
  10.1111/cas.13752
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10784, KAKENHI-PROJECT-18K15925, KAKENHI-PROJECT-15H04830, KAKENHI-PROJECT-16K19454
[Journal Article] Clinical significance of repeat rebiopsy in detecting the EGFR T790M secondary mutation in patients with non-small cell lung cancer2018
- Author(s)
  Ichihara Eiki、Hotta Katsuyuki、Kubo Toshio、Higashionna Tsukasa、Ninomiya Kiichiro、Ohashi Kadoaki、Tabata Masahiro、Maeda Yoshinobu、Kiura Katsuyuki
- Journal Title
  
  Oncotarget
  
  Volume: 9 Issue: 50 Pages: 29525-29531
- DOI
  10.18632/oncotarget.25705
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15925, KAKENHI-PROJECT-15H04830
[Journal Article] Osimertinib Depletes EGFR T790M in the Spinal Fluid of Patients with Carcinomatous Meningitis of Lung Adenocarcinoma Harboring De Novo EGFR T790M.2018
- Author(s)
  Senoo S, Ohashi K, Nishii K, Hara N, Kano H, Ninomiya K, Maeda Y, Kiura K.
- Journal Title
  
  J Thorac Oncol.
  
  Volume: 13 Issue: 8 Pages: e140-e142
- DOI
  10.1016/j.jtho.2018.03.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04830, KAKENHI-PROJECT-16K19454
[Journal Article] Second primary cancer in survivors of locally advanced non-small cell lung cancer treated with concurrent chemoradiation followed by surgery2018
- Author(s)
  Makimoto Go、Kubo Toshio、Oze Isao、Ohashi Kadoaki、Hotta Katsuyuki、Tabata Masahiro、Soh Junichi、Toyooka Shinichi、Katsui Kuniaki、Takigawa Nagio、Tanimoto Mitsune、Kiura Katsuyuki
- Journal Title
  
  Japanese Journal of Clinical Oncology
  
  Volume: 48 Issue: 3 Pages: 287-290
- DOI
  10.1093/jjco/hyy003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04830, KAKENHI-PROJECT-16K15458, KAKENHI-PROJECT-18K15925
[Journal Article] A phase I trial of afatinib and bevacizumab in chemo-naive patients with advanced non-small-cell lung cancer harboring EGFR mutations: Okayama Lung Cancer Study Group Trial 1404.2018
- Author(s)
  Ninomiya T, Nogami N, Kozuki T, Harada D, Kubo T, Ohashi K, Kuyama S, Kudo K, Bessho A, Fukamatsu N, Fujimoto N, Aoe K, Shibayama T, Sugimoto K, Takigawa N, Hotta K, Kiura K.
- Journal Title
  
  Lung Cancer.
  
  Volume: 115 Pages: 103-108
- DOI
  10.1016/j.lungcan.2017.11.025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19454, KAKENHI-PROJECT-15H04830, KAKENHI-PROJECT-16K15458, KAKENHI-PROJECT-18K15925
[Journal Article] A Phase II Study of Trastuzumab Emtansine in HER2-Positive Non-Small Cell Lung Cancer2018
- Author(s)
  Hotta Katsuyuki、Aoe Keisuke、Kozuki Toshiyuki、Ohashi Kadoaki、Ninomiya Kiichiro、Ichihara Eiki、Kubo Toshio、Ninomiya Takashi、Chikamori Kenichi、Harada Daijiro、Nogami Naoyuki、Hirata Taizo、Hinotsu Shiro、Toyooka Shinichi、Kiura Katsuyuki
- Journal Title
  
  Journal of Thoracic Oncology
  
  Volume: 13 Issue: 2 Pages: 273-279
- DOI
  10.1016/j.jtho.2017.10.032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04830, KAKENHI-PROJECT-16K15458, KAKENHI-PROJECT-18K15925
[Journal Article] Potential influence of interleukin-6 on the therapeutic effect of gefitinib in patients with advanced non-small cell lung cancer harbouring EGFR mutations.2018
- Author(s)
  Tamura T, Kato Y, Ohashi K, Ninomiya K, Makimoto G, Gotoda H, Kubo T, Ichihara E, Tanaka T, Ichimura K, Maeda Y, Hotta K, Kiura K.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 495 Issue: 1 Pages: 360-367
- DOI
  10.1016/j.bbrc.2017.10.175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19454, KAKENHI-PROJECT-15H04830, KAKENHI-PROJECT-26430163, KAKENHI-PROJECT-16K15458
[Journal Article] Discomfort during bronchoscopy performed after endobronchial intubation with fentanyl and midazolam: a prospective study.2017
- Author(s)
  Minami D, Takigawa N, Kano H, Ninomiya T, Kubo T, Ichihara E, Ohashi K, Sato A, Hotta K, Tabata M, Tanimoto M, Kiura K.
- Journal Title
  
  Jpn J Clin Oncol.
  
  Volume: Epub Issue: 5 Pages: 434-437
- DOI
  10.1093/jjco/hyx022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19454
[Journal Article] Triplet therapy with afatinib, cetuximab, and bevacizumab induces deep remission in lung cancer cells harboring EGFR T790M in vivo.2017
- Author(s)
  Kudo K, Ohashi K, Makimoto G, Higo H, Kato Y, Kayatani H, Kurata Y, Takami Y, Minami D, Ninomiya T, Kubo T, Ichihara E, Sato A, Hotta K, Yoshino T, Tanimoto M, Kiura K.
- Journal Title
  
  Mol Oncol
  
  Volume: Epub Issue: 6 Pages: 670-681
- DOI
  10.1002/1878-0261.12063
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04830, KAKENHI-PROJECT-16K19454, KAKENHI-PROJECT-16K15458
[Journal Article] A phase II trial of carboplatin plus S-1 for elderly patients with advanced non-small-cell lung cancer with wild-type epidermal growth factor receptor: The Okayama Lung Cancer Study Group Trial 12022017
- Author(s)
  Kuyama Shoichi、Ochi Nobuaki、Bessho Akihiro、Hotta Katsuyuki、Ikeda Genyo、Kishino Daizo、Kubo Toshio、Harada Daijiro、Fujimoto Nobukazu、Nakanishi Masamoto、Umeno Takahiro、Okada Toshiaki、Chikamori Kenichi、Yamagishi Tomoko、Ohashi Kadoaki、Ichihara Eiki、Takigawa Nagio、Tanimoto Mitsune、Kiura Katsuyuki
- Journal Title
  
  Lung Cancer
  
  Volume: 112 Pages: 188-194
- DOI
  10.1016/j.lungcan.2017.08.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04830, KAKENHI-PROJECT-16K15458
[Journal Article] Effect of Vandetanib on Lung Tumorigenesis in Transgenic Mice Carrying an Activating Egfr Gene Mutation.2016
- Author(s)
  Osawa M, Ohashi K, Kubo T, Ichihara E, Takata S, Takigawa N, Takata M, Tanimoto M, Kiura K.
- Journal Title
  
  Acta Med Okayama.
  
  Volume: 70 Pages: 243-253
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19454
[Journal Article] Safety and discomfort during bronchoscopy performed under sedation with fentanyl and midazolam: a prospective study.2016
- Author(s)
  Minami D, Takigawa N, Watanabe H, Ninomiya T, Kubo T, Ohashi K, Sato A, Hotta K, Tabata M, Tanimoto M, Kiura K.
- Journal Title
  
  Jpn J Clin Oncol.
  
  Volume: 46 Issue: 9 Pages: 871-4
- DOI
  10.1093/jjco/hyw083
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15458
[Journal Article] Endobronchial ultrasound-guided transbronchial needle aspiration of hilar and mediastinal lymph nodes detected on 18F-fluorodeoxyglucose positron emission tomography/computed tomography2016
- Author(s)
  Minami D, Takigawa N, Oda N, Ninomiya T, Kubo T, Ohashi K, Sato A, Hotta K, Tabata M, Kaji M, Tanimoto M, Kiura K..
- Journal Title
  
  Jpn J Clin Oncol.
  
  Volume: 46 Issue: 6 Pages: 529-33
- DOI
  10.1093/jjco/hyw023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15458
[Journal Article] Potential influence of being overweight on the development of hepatic dysfunction in Japanese patients with EGFR-mutated non-small cell lung cancer undergoing gefitinib monotherapy: the Okayama Lung Cancer Study Group experience.2016
- Author(s)
  Oda N, Hotta K, Yoshioka H, Kudo K, Ichihara E, Kato Y, Ninomiya K, Minami D, Ninomiya T, Kubo T, Ohashi K, Sato A, Takigawa N, Tabata M, Tanimoto M, Kiura K.
- Journal Title
  
  Cancer Chemother Pharmacol.
  
  Volume: 78 Issue: 5 Pages: 941-47
- DOI
  10.1007/s00280-016-3146-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15458
[Journal Article] Potential influence of being overweight on the development of hepatic dysfunction in Japanese patients with EGFR-mutated non-small cell lung cancer undergoing gefitinib monotherapy: the Okayama Lung Cancer Study Group experience.2016
- Author(s)
  Oda N, Hotta K, Yoshioka H, Kudo K, Ichihara E, Kato Y, Ninomiya K, Minami D, Ninomiya T, Kubo T, Ohashi K, Sato A, Takigawa N, Tabata M, Tanimoto M, Kiura K.
- Journal Title
  
  Cancer Chemother Pharmacol.
  
  Volume: ７８ Pages: 941-947
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19454
[Journal Article] NF-κB drives acquired resistance to a novel mutant-selective EGFR inhibitor.2015
- Author(s)
  Galvani E, Sun J, Leon LG, Sciarrillo R, Narayan RS, Sjin RT, Lee K, Ohashi K, Heideman DA, Alfieri RR, Heynen GJ, Bernards R, Smit EF, Pao W, Peters GJ, Giovannetti E.
- Journal Title
  
  Oncotarget
  
  Volume: ６ Issue: 40 Pages: 42717-32
- DOI
  10.18632/oncotarget.3956
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26893155
[Patent] ＲＥＩＣ／Ｄｋｋ－３遺伝子を含むＥＧＦＲ遺伝子変異陽性肺癌の治療薬2022
- Inventor(s)
  公文裕巳, 大橋圭明, 木浦勝行他
- Industrial Property Rights Holder
  公文裕巳, 大橋圭明, 木浦勝行他
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-19H03667
[Presentation] Egfr変異陽性肺癌に対する Ad-SGE-REICと抗PD-1抗体併用による抗腫瘍免疫賦活効果2022
- Author(s)
  中須賀崇匡，大橋圭明，西井和也，平生敦子，大川祥，髙田健二，西村淳，栗林忠弘，安東千裕，西達也，森田絢子，槇本剛，二宮貴一朗，藤井昌学，市原英基，堀田勝幸，田端雅弘，前田嘉信，木浦勝行
- Organizer
  第63回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24339
[Presentation] EGFR阻害が誘導するEgfr肺癌に対する抗腫瘍免疫を逐次的VEGFR-2/PD-1阻害が増強する2022
- Author(s)
  西井和也，大橋圭明，冨田秀太，中須賀崇匡，平生敦子，大川祥，西村淳，安東千裕，槇本剛，二宮貴一朗，加藤有加，久保寿夫，市原英基，堀田勝幸，田端雅弘，豊岡伸一，鵜殿平一郎，前田嘉信，木浦勝行
- Organizer
  第63回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03667
[Presentation] EGFR阻害が誘導するEgfr肺癌に対する抗腫瘍免疫を逐次的VEGFR-2/PD-1阻害が増強する2022
- Author(s)
  西井和也，大橋圭明，冨田秀太，中須賀崇匡，平生敦子，大川祥，西村淳，安東千裕，槇本剛，二宮貴一朗，加藤有加，久保寿夫，市原英基，堀田勝幸，田端雅弘，豊岡伸一，鵜殿平一郎，前田嘉信，木浦勝行
- Organizer
  第63回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-22K19529
[Presentation] Egfr変異陽性肺癌に対する Ad-SGE-REICと抗PD-1抗体併用による抗腫瘍免疫賦活効果2022
- Author(s)
  中須賀崇匡，大橋圭明，西井和也，平生敦子，大川祥，髙田健二，西村淳，栗林忠弘，安東千裕，西達也，森田絢子，槇本剛，二宮貴一朗，藤井昌学，市原英基，堀田勝幸，田端雅弘，前田嘉信，木浦勝行
- Organizer
  第63回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-22K19529
[Presentation] EGFR阻害が誘導するEgfr肺癌に対する抗腫瘍免疫を逐次的VEGFR-2/PD-1阻害が増強する2022
- Author(s)
  西井和也，大橋圭明，冨田秀太，中須賀崇匡，平生敦子，大川祥，西村淳，安東千裕，槇本剛，二宮貴一朗，加藤有加，久保寿夫，市原英基，堀田勝幸，田端雅弘，豊岡伸一，鵜殿平一郎，前田嘉信，木浦勝行
- Organizer
  第63回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24339
[Presentation] Egfr変異陽性肺癌に対する Ad-SGE-REICと抗PD-1抗体併用による抗腫瘍免疫賦活効果2022
- Author(s)
  中須賀崇匡，大橋圭明，西井和也，平生敦子，大川祥，髙田健二，西村淳，栗林忠弘，安東千裕，西達也，森田絢子，槇本剛，二宮貴一朗，藤井昌学，市原英基，堀田勝幸，田端雅弘，前田嘉信，木浦勝行
- Organizer
  第63回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03667
[Presentation] Combined efect of Lorlatinib and Bcl-2 inhibitors in　intrinsic Alectinib resistant Lung Adenocarcinoma　Harboring the EML4-ALK Fusion Gene2021
- Author(s)
  Go Makimoto, Kadoaki Ohashi, Shuta Tomida, Kenji Takada, Hiromi Watanabe, Kazuya Nishii, Kiichiro Ninomiya, Yuka Kato, Toshio Kubo, Eiki Ichihara, Katsuyuki Hotta, Masahiro Tabata, Shinichi Toyooka, Yoshinobu Maeda and Katsuyuki Kiura
- Organizer
  1st JCA-AACR Precision Cancer Medicine International Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08625
[Presentation] Novel combined immunotherapy with EGFR-TKI follow by dual blockade of PD-1 and VGFR2 in lung cancer harboring Egfr mutation.2021
- Author(s)
  Kazuya Nishii,, Kadoaki Ohashi, Shuta Tomida, Takamasa Nakasuka, Atsuko Hirabae, Sachi Okawa, Hisao Higo, Hiromi Watanabe, Hirohisa Kano, Chihiro Ando, Go Makimoto, Kiichiro Ninomiya,et al and Heiichiro Udono, Yoshinobu Maeda, Katsuyuki Kiura
- Organizer
  1st JCA-AACR Precision Cancer Medicine International Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08625
[Presentation] Increased expression of amphiregulin may contribute to crizotinib resistance in lung cancer cells harboring ROS1 fusion genes2021
- Author(s)
  Hiromi Watanabe, Yuka Kato, Kadoaki Ohashi, Shuta Tomida, Kenji Takada, Kazuya Nishii, Go Makimoto, Kiichiro Ninomiya, Masanori Fujii, Toshio Kubo, Eiki Ichihara, Yoshinobu Maeda, Katsuyuki Kiura
- Organizer
  1st JCA-AACR Precision Cancer Medicine International Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08625
[Presentation] Combined effect of Lorlatinib and Bcl-2 inhibitors in　intrinsic Alectinib resistant Lung Adenocarcinoma　Harboring the EML4-ALK Fusion Gene2021
- Author(s)
  Go Makimoto, Kadoaki Ohashi, Shuta Tomida, Kenji Takada, Hiromi Watanabe, Kazuya Nishii, Kiichiro Ninomiya, Yuka Kato, Toshio Kubo, Eiki Ichihara, Katsuyuki Hotta, Masahiro Tabata, Shinichi Toyooka, Yoshinobu Maeda and Katsuyuki
- Organizer
  1st JCA-AACR Precision Cancer Medicine International Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03667
[Presentation] Novel combined immunotherapy with EGFR-TKI followed by dual blockade of PD-1 and VEGFR2 in lung cancer harboring Egfr mutation.2021
- Author(s)
  Kazuya Nishii, Kadoaki Ohashi, Shuta Tomida, et al, and Shinichi Toyooka, Heiichiro Udono, Yoshinobu Maeda, Katsuyuki Kiura
- Organizer
  1st JCA-AACR Precision Cancer Medicine International Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03667
[Presentation] Increased expression of amphiregulin may contribute to crizotinib resistance in lung cancer cells harboring ROS1 fusion genes2021
- Author(s)
  Hiromi Watanabe, Yuka Kato, Kadoaki Ohashi, Shuta Tomida, Kenji Takada, Kazuya Nishii, Go Makimoto, Kiichiro Ninomiya, Masanori Fujii, Toshio Kubo, Eiki Ichihara, Yoshinobu Maeda, Katsuyuki Kiura
- Organizer
  1st JCA-AACR Precision Cancer Medicine International Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03667
[Presentation] Therapeutic stimulation of nucleic acid receptor RIG-I enhances efficacy of kinase inhibitor treatment in oncogene-driven tumors2021
- Author(s)
  Johannes Bragelmann; Carina Lorenz; Sven Borchmann; Kazuya Nishii; Julia Wegner; Jenny Ostendorp; David Ast; Alena Heimsoeth; Philipp Lohneis; Thomas Zillinger; Roland Ullrich; Kadoaki Ohashi; Martin Schlee; Martin Sos
- Organizer
  AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08625
[Presentation] Egfr改変肺癌マウスモデルを用いたAd-SGE-REICの抗腫瘍効果の検討2020
- Author(s)
  中須賀崇匡, 大橋圭明, 西井和也, 平生敦子, 大川祥, 安東千裕, 原尚史, 狩野裕久, 渡邉洋美, 二宮貴一朗, 加藤有加, 二宮崇, 久保寿夫, 頼冠名, 市原英基, 堀田勝幸, 田端雅弘, 前田嘉信, 木浦勝行
- Organizer
  第61回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03667
[Presentation] Egfr改変肺癌マウスモデルを用いたpersisterがん細胞に対する根治的薬物療法の開発2020
- Author(s)
  大川祥，大橋圭明，原尚史，西井和也，中須賀崇匡，平生敦子，安東千裕，狩野裕久，渡邉洋美，二宮貴一朗，加藤有加，久保寿夫，頼冠名，市原英基，堀田勝幸，田端雅弘，前田嘉信，木浦勝行
- Organizer
  第61回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03667
[Presentation] Egfr改変肺癌マウスモデルを用いたEGFR-TKI、抗VEGFR-2抗体と抗PD-1抗体併用療法の検討2020
- Author(s)
  西井和也, 大橋圭明, 中須賀崇匡, 平生敦子, 大川祥, 渡邉洋美, 狩野裕久, 原尚史, 安東千裕, 二宮貴一朗, 加藤有加, 二宮崇, 久保寿夫, 頼冠名, 市原英基, 堀田勝幸, 田端雅弘, (鵜殿平一郎 ), 前田嘉信, 木浦勝行
- Organizer
  第61回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03667
[Presentation] Egfr改変肺癌マウスモデルを用いたEGFR-TKI、抗VEGFR-2抗体と抗PD-1抗体併用療法の検討2020
- Author(s)
  西井和也, 大橋圭明, 中須賀崇匡, 平生敦子, 大川祥, 渡邉洋美, 狩野裕久, 原尚史, 安東千裕, 二宮貴一朗, 加藤有加, 二宮崇, 久保寿夫, 頼冠名, 市原英基, 堀田勝幸, 田端雅弘, (鵜殿平一郎 ), 前田嘉信, 木浦勝行
- Organizer
  第61回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08625
[Presentation] Egfr改変肺癌マウスモデルを用いたpersisterがん細胞に対する根治的薬物療法の開発2020
- Author(s)
  大川祥，大橋圭明，原尚史，西井和也，中須賀崇匡，平生敦子，安東千裕，狩野裕久，渡邉洋美，二宮貴一朗，加藤有加，久保寿夫，頼冠名，市原英基，堀田勝幸，田端雅弘，前田嘉信，木浦勝行
- Organizer
  第61回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08625
[Presentation] Tumor immunoediting in a lung cancer mouse model harboring EGFR mutations2019
- Author(s)
  Kazuya Nishii, Kadoaki Ohashi, Kiichiro Ninomiya, Go Makimoto, Hiromi Watanabe, Hirohisa Kano, Naofumi Hara, Heiichiro Udono and Katsuyuki Kiura
- Organizer
  American Association for Cancer Research (AACR) 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08625
[Presentation] Tumor immunoediting in a lung cancer mouse model harboring EGFR mutations2019
- Author(s)
  Kazuya Nishii, Kadoaki Ohashi, Kiichiro Ninomiya, Go Makimoto, Hiromi Watanabe, Hirohisa Kano, Naofumi Hara, Heiichiro Udono and Katsuyuki Kiura
- Organizer
  American Association for Cancer Research (AACR)　annual meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03667
[Presentation] Rapid acquired resistance to alectinib in ALK-positive lung cancers with high tumor mutation burden2019
- Author(s)
  Kadoaki Ohashi, Go Makimoto, Shuta Tomida, Kazuya Nishii, Shinichi Toyooka and Katsuyuki Kiura
- Organizer
  American Association for Cancer Research (AACR) 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08625
[Presentation] In vivo efficacy of triplet therapy with osimertinib, cetuximab and bevacizumab for lung cancer cells harboring EGFR T790M2018
- Author(s)
  Kazuya Nishii, Kadoaki Ohashi, Go Makimoto, Hisao Higo, Kiichiro Ninomiya, Hiroe Kayatani, Takashi Ninomiya, Toshio Kubo, Kammei Rai, Eiki Ichihara, Katsuyuki Hotta, Masahiro Tabata, Katsuyuki Kiura
- Organizer
  AACR Annual Meeting 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04830
[Presentation] Novel Syngenic Lung Cancer Mouse Model Harboring EGFR Mutations2018
- Author(s)
  Kazuya Nishii, Kadoaki Ohashi, Hisao Higo, Kenichiro Kudo, Go Makimoto, Hiroe Kayatani, Hiromi Watanabe, Kiichiro Ninomiya, Takashi Ninomiya, Toshio Kubo, Kammei Rai, Eiki Ichihara, Katsuyuki Hotta, Masahiro Tabata, Katsuyuki Kiura
- Organizer
  The 6th JCA-AACR Special Joint Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04830
[Presentation] The novel osimertinib resistant lung cancer mice model harboring EGFR mutations driven by the SP-C promoter2018
- Author(s)
  Kadoaki Ohashi, Hisao Higo, Go Makimoto, Kenichiro Kudo, Kazuya Nishii, Kiichiro Ninomiya, Hiroe Kayatani, Takashi Ninomiya, Toshio Kubo, Kammei Rai, Eiki Ichihara, Katsuyuki Hotta, Masahiro Tabata, Katsuyuki Kiura
- Organizer
  AACR Annual Meeting 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04830
[Presentation] In vivo efficacy of triplet therapy with osimertinib, cetuximab and bevacizumab for lung cancer cells harboring EGFR T790M2018
- Author(s)
  Kazuya Nishii, Kadoaki Ohashi, Go Makimoto, Hisao Higo, Kiichiro Ninomiya, Hiroe Kayatani, Takashi Ninomiya, Toshio Kubo, Kammei Rai, Eiki Ichihara, Katsuyuki Hotta, Masahiro Tabata, Katsuyuki Kiura
- Organizer
  AACR Annual Meeting 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19454
[Presentation] Analysis of the Rapid Acquired Resistance of ALK-positive Lung Cancers to Alectinib: A Comprehensive Study Using Autopsied Specimens and Patient-derived Cell Lines2018
- Author(s)
  Go Makimoto, Kadoaki Ohashi, Kazuya Nishii, (Shuta Tomida), Hiroe Kayatani, Hisao Higo, Kiichiro Ninomiya, Hiromi Watanabe, Takashi Ninomiya, Toshio Kubo, Eiki Ichihara, Akiko Sato, Katsuyuki Hotta, Masahiro Tabata, Sinichi Toyooka, Yoshinobu Maeda, Katsuyuki Kiura
- Organizer
  The 6th JCA-AACR Special Joint Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19454
[Presentation] Contribution of nationwide genome screening in Japan (LC-SCRUM-Japan) to the development of precision medicine for non-small cell lung cancer.2018
- Author(s)
  Takashi Seto, Shingo Matsumoto, Kiyotaka Yoh, Yutaka Fujiwara, Takuma Yokoyama, Kazumi Nishino, Terufumi Kato, Shunichi Sugawara, Masato Shingoji, Masahiro Kodani, Kadoaki Ohashi, Katsuya Tsuchihara, Koichi Goto
- Organizer
  ASCO 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19454
[Presentation] Novel Syngenic Lung Cancer Mouse Model Harboring EGFR Mutations2018
- Author(s)
  Kazuya Nishii, Kadoaki Ohashi, Hisao Higo, Kenichiro Kudo, Go Makimoto, Hiroe Kayatani, Hiromi Watanabe, Kiichiro Ninomiya, Takashi Ninomiya, Toshio Kubo, Kammei Rai, Eiki Ichihara, Katsuyuki Hotta, Masahiro Tabata, Katsuyuki Kiura
- Organizer
  The 6th JCA-AACR Special Joint Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19454
[Presentation] Analysis of the Rapid Acquired Resistance of ALK-positive Lung Cancers to Alectinib: A Comprehensive Study Using Autopsied Specimens and Patient-derived Cell Lines2018
- Author(s)
  Go Makimoto, Kadoaki Ohashi, Kazuya Nishii, (Shuta Tomida), Hiroe Kayatani, Hisao Higo, Kiichiro Ninomiya, Hiromi Watanabe, Takashi Ninomiya, Toshio Kubo, Eiki Ichihara, Akiko Sato, Katsuyuki Hotta, Masahiro Tabata, (Sinichi Toyooka), Yoshinobu Maeda, Katsuyuki Kiura
- Organizer
  The 6th JCA-AACR Special Joint Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04830
[Presentation] The novel osimertinib resistant lung cancer mice model harboring EGFR mutations driven by the SP-C promoter2018
- Author(s)
  Kadoaki Ohashi, Hisao Higo, Go Makimoto, Kenichiro Kudo, Kazuya Nishii, Kiichiro Ninomiya, Hiroe Kayatani, Takashi Ninomiya, Toshio Kubo, Kammei Rai, Eiki Ichihara, Katsuyuki Hotta, Masahiro Tabata, Katsuyuki Kiura
- Organizer
  AACR Annual Meeting 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19454
[Presentation] A comprehensive analysis of autopsied specimens and patient-derived cell lines in ALK-positive lung cancers with rapid acquired resistance to alectinib2017
- Author(s)
  Go Makimoto, Kadoaki Ohashi, Kazuya Nishii, Shuta Tomida, Hiroe Kayatani, Tomoki Tamura, Hisao Higo, Kiichiro Ninomiya, Takashi Ninomiya, Toshio Kubo, Eiki Ichihara, Akiko Sato, Katsuyuki Hotta, Masahiro Tabata, Katsuyuki Kiura
- Organizer
  AACR Annual Meeting 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04830
[Presentation] Acquired resistance to the third-generation EGFR inhibitor ASP8273 is associated with MET or NRAS gene amplifications in preclinical models2017
- Author(s)
  Kiichiro Ninomiya, Kadoaki Ohashi, Shuta Tomida, Hiroe Kayatani, Tomoki Tamura, Hisao Higo, Go Makimoto, Takashi Ninomiya, Toshio Kubo, Eiki Ichihara, Akiko Sato, Katsuyuki Hotta, Masahiro Tabata, Katsuyuki Kiura.
- Organizer
  AACR Annual Meeting 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04830
[Presentation] A comprehensive analysis of autopsied specimens and patient-derived cell lines in ALK-positive lung cancers with rapid acquired resistance to alectinib2017
- Author(s)
  Go Makimoto, Kadoaki Ohashi, Kazuya Nishii, Shuta Tomida, Hiroe Kayatani, Tomoki Tamura, Hisao Higo, Kiichiro Ninomiya, Takashi Ninomiya, Toshio Kubo, Eiki Ichihara, Akiko Sato, Katsuyuki Hotta, Masahiro Tabata, Katsuyuki Kiura
- Organizer
  AACR Annual Meeting 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15458
[Presentation] Abstract 3164: A comprehensive analysis of autopsied specimens and patient-derived cell lines in ALK-positive lung cancers with rapid acquired resistance to alectinib2017
- Author(s)
  Go Makimoto, Kadoaki Ohashi, Kazuya Nishii, Shuta Tomida, Hiroe Kayatani, Tomoki Tamura, Hisao Higo, Kiichiro Ninomiya, Takashi Ninomiya, Toshio Kubo, Eiki Ichihara, Akiko Sato, Katsuyuki Hotta, Masahiro Tabata and Katsuyuki Kiura
- Organizer
  AACR 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19454
[Presentation] Acquired resistance to the third-generation EGFR inhibitor ASP8273 is associated with MET or NRAS gene amplifications in preclinical models2017
- Author(s)
  Kiichiro Ninomiya, Kadoaki Ohashi, Shuta Tomida, Hiroe Kayatani, Tomoki Tamura, Hisao Higo, Go Makimoto, Takashi Ninomiya, Toshio Kubo, Eiki Ichihara, Akiko Sato, Katsuyuki Hotta, Masahiro Tabata, Katsuyuki Kiura.
- Organizer
  AACR Annual Meeting 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15458
[Presentation] Abstract 3152: Acquired resistance to the third-generation EGFR inhibitor ASP8273 is associated with MET or NRAS gene amplifications in preclinical models2017
- Author(s)
  Kiichiro Ninomiya, Kadoaki Ohashi, Shuta Tomida, Hiroe Kayatani, Tomoki Tamura, Hisao Higo, Go Makimoto, Takashi Ninomiya, Toshio Kubo, Eiki Ichihara, Akiko Sato, Katsuyuki Hotta, Masahiro Tabata and Katsuyuki Kiura
- Organizer
  AACR 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19454
[Presentation] Abstract 4667: pCR induced by triplet therapy with low-dose afatinib, cetuximab and bevcizumab in lung cancer cells harboring EGFR T790M2016
- Author(s)
  AKadoaki Ohashi, Kenichiro Kudo, Eiki Ichihara, Hiroe Kayatani, Hisao Higo, Yuka Kato, Yasuko Kurata, Daisuke Minami, Takashi Ninomiya, Toshio Kubo, Katsuyuki Hotta, Mitsune Tanimoto, Katsuyuki Kiura
- Organizer
  AACR 2016
- Place of Presentation
  Ernest N. Morial Convention Center New Orleans, Louisiana
- Year and Date
  2016-04-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04830
[Presentation] Abstract 1889: AXL and EGFR signaling mediate resistance to Crizotinib in non-small cell lung cancer cells harboring the ROS1 fusion gene2016
- Author(s)
  Yuka Kato, Kadoaki Ohashi, Eiki Ichihara, Shuuta Tomida, Hiroe Kayatani, Kenichiro Kudo, Daisuke Minami, Takashi Ninomiya, Toshio Kubo, Toshiyuki Kozuki, Katsuyuki Hotta, Nagio Takigawa, Mitsune Tanimoto, Katsuyuki Kiura
- Organizer
  AACR 2016
- Place of Presentation
  Ernest N. Morial Convention Center New Orleans, Louisiana
- Year and Date
  2016-04-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04830
[Presentation] Abstract 250: Interleukin-6 as potential predictive marker for therapeutic effect of Gefitinib in patients with advanced non-small-cell lung cancer harboring EGFR mutations2016
- Author(s)
  Tomoki Tamura, Katsuyuki Hotta, Yuka Kato, Takehiro Tanaka, Kouichi Ichimura, Kadoaki Oohashi, Takashi Ninomiya, Toshio Kubo, Eiki Ichihara, Mitsune Tanimoto, Katsuyuki Kiura
- Organizer
  AACR 2016
- Place of Presentation
  Ernest N. Morial Convention Center New Orleans, Louisiana
- Year and Date
  2016-04-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04830
[Presentation] Second primary cancer in survivors of locally advanced NSCLC treated with concurrent chemoradiation followed by surgery.2016
- Author(s)
  Go Makimoto, Toshio Kubo, Yuka Kato, Takashi Ninomiya, Isao Oze, Kadoaki Ohashi, Eiki Ichihara, Katsuyuki Hotta, Masahiro Tabata, Nagio Takigawa, Shinichi Toyooka, Kuniaki Katsui, Mitsune Tanimoto, Katsuyuki Kiura
- Organizer
  2016 ASCO Annual Meeting
- Place of Presentation
  Chicago
- Year and Date
  2016-06-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15458
[Presentation] Abstract 5198: Combination effect of anti-VEGFR-2 antibody with erlotinib on EGFR mutant non-small cell lung cancer2016
- Author(s)
  Hiroe Kayatani, Kadoaki Ohashi, Takeshi Imao, Kenichiro Kudo, Yuka Kato, Takashi Ninomiya, Toshio Kubo, Akiko Sato, Ktsuyuki Hotta, Mitsune Tanimoto, Katsuyuki Kiura
- Organizer
  AACR 2016
- Place of Presentation
  Ernest N. Morial Convention Center New Orleans, Louisiana
- Year and Date
  2016-04-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04830
[Presentation] Combination effect of anti-VEGFR-2 antibody with erlotinib on EGFR mutant non-small cell lung cancer2016
- Author(s)
  Hiroe Kayatani, Kadoaki Ohashi, Takeshi Imao, Kenichiro Kudo, Yuka Kato, Takashi Ninomiya, Toshio Kubo, Akiko Sato, Ktsuyuki Hotta, Mitsune Tanimoto and Katsuyuki Kiura
- Organizer
  AACR 2016
- Place of Presentation
  Ernest N. Morial Convention Center New Orleans, Louisiana
- Year and Date
  2016-04-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19454
[Presentation] EGFR変異を有する肺癌細胞株における第三世代EGFR-TKI耐性機序の検討2016
- Author(s)
  二宮　貴一朗、大橋　圭明　他
- Organizer
  JSMO 2016
- Place of Presentation
  神戸国際展示場
- Year and Date
  2016-07-28
- Data Source
  KAKENHI-PROJECT-16K19454
[Presentation] pCR induced by triplet therapy with low-dose afatinib, cetuximab and bevcizumab in lung cancer cells harboring EGFR T790M2016
- Author(s)
  Kadoaki Ohashi, Kenichiro Kudo, Eiki Ichihara, Hiroe Kayatani, Hisao Higo, Yuka Kato, Yasuko Kurata, Daisuke Minami, Takashi Ninomiya, Toshio Kubo, Katsuyuki Hotta, Mitsune Tanimoto and Katsuyuki Kiura
- Organizer
  AACR 2016
- Place of Presentation
  Ernest N. Morial Convention Center New Orleans, Louisiana
- Year and Date
  2016-04-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19454
[Presentation] The impact of bevacizumab on combination low-dose afatinib and cetuximab therapy in lung cancer cells harboring activated EGFR mutations2015
- Author(s)
  Kenichiro Kudo, Kadoaki Ohashi, Eiki Ichihara,Toshio Kubo, Daisuke Minami, Akiko Sato,Katsuyuki Hotta, Mitsune Tanimoto, Katsuyuki Kiura
- Organizer
  第55回日本呼吸器学会学術講演会
- Place of Presentation
  東京
- Year and Date
  2015-04-18
- Data Source
  KAKENHI-PROJECT-26893155
[Presentation] The impact of bevacizumab on combination low-dose afatinib and cetuximab therapy in lung cancer cells harboring activated EGFR mutations2015
- Author(s)
  Kenichiro Kudo, Kadoaki Ohashi, Eiki Ichihara,Toshio Kubo, Daisuke Minami, Akiko Sato,Katsuyuki Hotta, Mitsune Tanimoto, Katsuyuki Kiura
- Organizer
  AACR Annual Meeting 2015
- Place of Presentation
  Pennsylvania Convention Center Philadelphia, Pennsylvania
- Year and Date
  2015-04-19
- Data Source
  KAKENHI-PROJECT-26893155
[Presentation] The impact of bevacizumab on combination low-dose afatinib and cetuximab therapy in lung cancer cells harboring activated EGFR mutations2015
- Author(s)
  Kenichiro Kudo, Kadoaki Ohashi, Eiki Ichihara, Daisuke Minami, Hisao Kubo, Akiko Sato, Yuka Kato, Hideko Isozaki, Hiroe Kayatani, Tomoki Tamura, Mitsune Tanimoto, and Katsuyuki Kiura
- Organizer
  American Asociation of Cancer Research　Annual meeting 2015
- Place of Presentation
  Pennsylvania Convention Center Philadelphia, Pennsylvania, USA
- Year and Date
  2015-04-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26893155
[Presentation] The impact of bevacizumab on combination low-dose afatinib and cetuximab therapy in lung cancer cells harboring activated EGFR mutations2015
- Author(s)
  Kenichiro Kudo, Kadoaki Ohashi, Eiki Ichihara, Daisuke Minami, Hisao Kubo, Akiko Sato, Yuka Kato, Hideko Isozaki, Hiroe Kayatani, Tomoki Tamura, Mitsune Tanimoto, and Katsuyuki Kiura
- Organizer
  第５５回日本呼吸器学会学術講演会
- Place of Presentation
  東京国際フォーラム、東京
- Year and Date
  2015-04-18
- Data Source
  KAKENHI-PROJECT-26893155

1. Kiura Katsuyuki (10243502)

# of Collaborated Projects: 6 results

# of Collaborated Products: 54 results
2. Tomida Shuta (10372111)

# of Collaborated Projects: 4 results

# of Collaborated Products: 7 results
3. 久保寿夫 (90726928)

# of Collaborated Projects: 2 results

# of Collaborated Products: 21 results
4. 豊岡伸一 (30397880)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. 山本寛斉 (40467733)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 諏澤憲 (90839713)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 公文裕巳 (30144760)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 山本英喜 (10581697)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 片山量平 (60435542)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 冨樫庸介 (80758326)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 遠西大輔 (20825096)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 枝園和彦 (30708079)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. Yoshida Tadashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. Takata Minoru

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. HIGO Hisao

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
16. Makimoto Go

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
17. Nishii Kazuya

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
18. TAKEUCHI Shinji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 鵜殿平一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OHASHI KADOAKI 大橋 圭明

Ohashi Kadoaki 大橋 圭明

Research Projects

Research Products

Co-Researchers

Two aspects of tumor-infiltrating lymphocytes in lung cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional analysis of TLS, tumor-infiltrating B-cell, by spatial multi-omics profiling and its application to tumor immunotherapy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Oct4陽性肺癌幹細胞マウスモデルの樹立と癌幹細胞を根絶する革新的治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

persister癌細胞と腫瘍微小環境の双方を標的とした革新的腫瘍免疫療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of next-generation precision medicine targeting the pathways on which driver gene mutation-positive lung cancer depends

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a curative treatment strategy for lung cancer using the persister cancer cell mouse model.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of innovative immunotherapy for lung cancer using tumor immune-activating gene REIC

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Comprehensive analysis of druggable tyrosine kinase in idiopathic interstitial pneumonia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

In vivo efficacy of triplet therapy with osimertinib, cetuximab and bevacizumab for lung cancer cells harboring EGFR T790MPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Next generation lung cancer mice model for conquering cancer stem

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The impact of bevacizumab on EGFR-TKI and anti-EGFR antibodyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] PD-1 blockade augments CD8+ T cell dependent antitumor immunity triggered by Ad-SGE-REIC in Egfr-mutant lung cancer.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CD8+ T-cell responses are boosted by dual PD-1/VEGFR2 blockade after EGFR inhibition in Egfrmutant lung cancer.2022

Author(s)

Journal Title

DOI

OHASHI KADOAKI 大橋圭明

Ohashi Kadoaki 大橋圭明