Kakihana Taichi 垣花太一

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KAKIHANA Taichi 垣花太一

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Researcher Number	60746907
Other IDs	https://orcid.org/0000-0001-5037-9184
Affiliation (Current)	2025: 新潟大学, 医歯学系, 助教
Affiliation (based on the past Project Information) *help	2019 – 2025: 新潟大学, 医歯学系, 助教 2016: 大阪大学, 医学系研究科, 特任研究員(常勤) 2015: 大阪大学, 医学(系)研究科(研究院), 特任研究員
Review Section/Research Field	Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Basic Section 43030:Functional biochemistry-related / Basic Section 54010:Hematology and medical oncology-related / Structural biochemistry Except Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
Keywords	Principal Investigator ストレス顆粒 / 筋萎縮性側索硬化症 / 翻訳品質管理 / ウイルス感染症 / タンパク質凝集体 / 神経変性疾患 / ALS / 亜ヒ酸 / ROS / HTLV-1 … More / Tax / ATL / MAGI-1 / 小胞体 / オートファジー … More Except Principal Investigator 感染動物モデル / ウイルス受容体ノックインマウス / 重症ヒトパレコウイルス3型感染症 / ヒトパレコウイルス / 異所性DNA / 加齢関連疾患 / ウイルスDNA / ミトコンドリアDNA / 核DNA / 老化 / 異所性のDNA Less

Establishment of a mouse model of human parechovirus A3 infection and elucidation of the mechanism of severe infection
- Principal Investigator
  
  渡邉香奈子
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Niigata University
異常なストレス顆粒によるタンパク質凝集体形成メカニズムを解明するPrincipal Investigator
- Principal Investigator
  
  垣花太一
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Niigata University
ウイルス感染症におけるリボソーム翻訳品質管理機構を理解するPrincipal Investigator
- Principal Investigator
  
  垣花太一
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Niigata University
異所性のDNAがもたらす老化・加齢関連疾患・感染症病態の網羅的比較解析
- Principal Investigator
  
  松井秀彰
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Niigata University
Exploratiion of mechanisms for formation of aberrant stress granules and TDP-43 aggregatesPrincipal Investigator
- Principal Investigator
  
  Kakihana Taichi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Niigata University
Regulation of arsenite sensitivity in adult T-cell leukemia by MAGI-1Principal Investigator
- Principal Investigator
  
  KAKIHANA Taichi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Niigata University
Analysis of dynamics of autophagosome formation by electron tomographyPrincipal Investigator
- Principal Investigator
  
  Kakihana Taichi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Osaka University

All 2024 2023 2022 2021 2019 2015

All Journal Article Presentation

[Journal Article] Genetic engineering employing MPB70 and its promoter enables efficient secretion and expression of foreign antigen in bacillus Calmette Gu?rin (BCG) Tokyo2024
- Author(s)
  Takeishi Atsuki、Shaban Amina K.、Kakihana Taichi、(22 persos)、Matsumoto Sohkichi
- Journal Title
  
  Microbiology and Immunology
  
  Volume: 68 Issue: 4 Pages: 130-147
- DOI
  10.1111/1348-0421.13116
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07291, KAKENHI-PROJECT-23K24374
[Journal Article] USP10 Inhibits Aberrant Cytoplasmic Aggregation of TDP-43 by Promoting Stress Granule Clearance2022
- Author(s)
  Takahashi Masahiko、Kitaura Hiroki、Kakita Akiyoshi、Kakihana Taichi、Katsuragi Yoshinori、Onodera Osamu、Iwakura Yuriko、Nawa Hiroyuki、Komatsu Masaaki、Fujii Masahiro
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 42 Issue: 3
- DOI
  10.1128/mcb.00393-21
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-19H05706, KAKENHI-PROJECT-21H04771, KAKENHI-PROJECT-19H03432, KAKENHI-PROJECT-21H02394, KAKENHI-PROJECT-21K07291, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-20K07757, KAKENHI-PROJECT-19H03542
[Journal Article] USP10 inhibits the dopamine-induced reactive oxygen species-dependent apoptosis of neuronal cells by stimulating the antioxidant Nrf2 activity2022
- Author(s)
  Sango Junya、Kakihana Taichi、Takahashi Masahiko、Katsuragi Yoshinori、Anisimov Sergei、Komatsu Masaaki、Fujii Masahiro
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 298 Issue: 1 Pages: 101448-101448
- DOI
  10.1016/j.jbc.2021.101448
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16142, KAKENHI-PLANNED-19H05706, KAKENHI-PROJECT-21H04771, KAKENHI-PROJECT-19H03432, KAKENHI-PROJECT-20K07757, KAKENHI-PROJECT-21K07291, KAKENHI-PROJECT-23K24091
[Journal Article] The optineurin/TIA1 pathway inhibits aberrant stress granule formation and reduces ubiquitinated TDP-432021
- Author(s)
  Kakihana Taichi、Takahashi Masahiko、Katsuragi Yoshinori、Yamashita Shun-Ichi、Sango Junya、Kanki Tomotake、Onodera Osamu、Fujii Masahiro
- Journal Title
  
  iScience
  
  Volume: 24 Issue: 7 Pages: 102733-102733
- DOI
  10.1016/j.isci.2021.102733
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-19H05712, KAKENHI-PROJECT-19H03432, KAKENHI-PROJECT-20K07757, KAKENHI-PROJECT-21K07291
[Journal Article] G3BP1 inhibits ubiquitinated protein aggregations induced by p62 and USP102019
- Author(s)
  Anisimov S, Takahashi M, Kakihana T, Katsuragi Y, Kitaura H, Zhang L, Kakita A, Fujii M.
- Journal Title
  
  Sci Rep
  
  Volume: 9(1) Issue: 1 Pages: 12896-12896
- DOI
  10.1038/s41598-019-46237-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17822, KAKENHI-PROJECT-19H03432, KAKENHI-PROJECT-19H03542, KAKENHI-PROJECT-16K09822, KAKENHI-PROJECT-17K07380, KAKENHI-PROJECT-17K09918
[Journal Article] USP10 is a critical factor for Tau-positive stress granule formation in neuronal cells2019
- Author(s)
  Piatnitskaia S, Takahashi M, Kitaura H, Katsuragi Y, Kakihana T, Zhang L, Kakita A, Iwakura Y, Nawa H, Miura T, Ikeuchi T, Hara T, Fujii M
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 10591-10591
- DOI
  10.1038/s41598-019-47033-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07698, KAKENHI-PROJECT-19K17822, KAKENHI-PROJECT-19H03432, KAKENHI-PROJECT-19H03542, KAKENHI-PROJECT-16K09822, KAKENHI-PROJECT-17K07380, KAKENHI-PROJECT-17K09918
[Journal Article] Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments.2015
- Author(s)
  Kirstein J, Morito D, Kakihana T, Sugihara M, Minnen A, Hipp MS, Nussbaum-Krammer C, Kasturi P, Hartl FU, Nagata K, Morimoto RI.
- Journal Title
  
  The EMBO Journal
  
  Volume: 34 Issue: 18 Pages: 2334-49
- DOI
  10.15252/embj.201591711
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07062, KAKENHI-PROJECT-15K18489, KAKENHI-PUBLICLY-15H01546, KAKENHI-PROJECT-24227009
[Presentation] p62液滴とストレス顆粒形成制御によるNrf2抗酸化ストレス経路の活性化とドパミン誘導性神経細胞死の抑制2023
- Author(s)
  Taichi Kakihana, Junya Sango, Masahiko Takahashi, Masahiro Fujii
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K07291
[Presentation] p62-body and stress granule regulate dopamine-induced neuronal cell death through activation of the Nrf2 antioxidant pathway2023
- Author(s)
  Taichi Kakihana, Junya Sango, Masahiko Takahashi, Masahiro Fujii
- Organizer
  the 24th RNA Society of Japan
- Data Source
  KAKENHI-PROJECT-21K07291
[Presentation] 神経変性疾患におけるストレス顆粒形成異常の分子メカニズム2023
- Author(s)
  垣花太一
- Organizer
  東北大学学際科学部フロンティア研究所セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-21K07291
[Presentation] Optineurin/TIA1 pathway reduces ubiquitinated TDP-43 aggregation by promoting stress granule clearance2022
- Author(s)
  Kakihana T, Takahashi M, Katsuragi Y, Yamashita SH, Kanki T, Onodera O, Fujii M.
- Organizer
  Neuro2022
- Data Source
  KAKENHI-PROJECT-21K07291
[Presentation] ストレス顆粒形成異常の分子機構の解明2022
- Author(s)
  垣花太一
- Organizer
  第15回小胞体ストレス研究会
- Data Source
  KAKENHI-PROJECT-21K07291
[Presentation] Optineurin prevents aberrant stress granule formation by reducing TIA1 expre ssion2019
- Author(s)
  垣花太一、藤井雅寛
- Organizer
  第92回生化学会大会
- Data Source
  KAKENHI-PROJECT-19K17822

1. 渡邉香奈子 (80626094)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 松井秀彰 (60710853)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 藤井雅寛 (30183099)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 齋藤昭彦 (30531389)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 高橋雅彦 (80377192)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. MORITO Daisuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. NAGATA Kazuhiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. SUGIHARA Munechika

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. SUGIURA Yuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 小松雅明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 神吉智丈

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 原敏文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. アニシモフセルゲイ

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kakihana Taichi 垣花 太一

KAKIHANA Taichi 垣花 太一

Research Projects

Research Products

Co-Researchers

Establishment of a mouse model of human parechovirus A3 infection and elucidation of the mechanism of severe infection

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

異常なストレス顆粒によるタンパク質凝集体形成メカニズムを解明するPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ウイルス感染症におけるリボソーム翻訳品質管理機構を理解するPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

異所性のDNAがもたらす老化・加齢関連疾患・感染症病態の網羅的比較解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploratiion of mechanisms for formation of aberrant stress granules and TDP-43 aggregatesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulation of arsenite sensitivity in adult T-cell leukemia by MAGI-1Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of dynamics of autophagosome formation by electron tomographyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Genetic engineering employing MPB70 and its promoter enables efficient secretion and expression of foreign antigen in bacillus Calmette Gu?rin (BCG) Tokyo2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] USP10 Inhibits Aberrant Cytoplasmic Aggregation of TDP-43 by Promoting Stress Granule Clearance2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] USP10 inhibits the dopamine-induced reactive oxygen species-dependent apoptosis of neuronal cells by stimulating the antioxidant Nrf2 activity2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The optineurin/TIA1 pathway inhibits aberrant stress granule formation and reduces ubiquitinated TDP-432021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] G3BP1 inhibits ubiquitinated protein aggregations induced by p62 and USP102019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] USP10 is a critical factor for Tau-positive stress granule formation in neuronal cells2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments.2015

Author(s)

Journal Title

Kakihana Taichi 垣花太一

KAKIHANA Taichi 垣花太一