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SIMOKAWA Isao  下川 功

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… Alternative Names

SHIMOKAWA Isao  下川 功

SHIMOAKAWA Isao  下川 功

下川 功  シモカワ イサオ

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Researcher Number 70187475
Other IDs
External Links
Affiliation (Current) 2025: 長崎大学, 医歯薬学総合研究科(医学系), 客員研究員
Affiliation (based on the past Project Information) *help 2023 – 2024: 長崎大学, 医歯薬学総合研究科(医学系), 客員研究員
2014 – 2021: 長崎大学, 医歯薬学総合研究科(医学系), 教授
2015: 長崎大学, 医歯(薬)学総合研究科, 教授
2013: 長崎大学, 大学院医歯薬学総合研究科, 教授
2011 – 2013: 長崎大学, 医歯(薬)学総合研究科, 教授 … More
2008 – 2011: Nagasaki University, 大学院・医歯薬学総合研究科, 教授
2007 – 2008: 長崎大学, 医歯(薬)学総合研究科, 教授
2007: Nagasaki University, 医歯薬学総合研究科, 教授
2003 – 2005: 長崎大学, 大学院・医歯薬学総合研究科, 教授
2000 – 2001: Nagasaki University, School of Medicine, Pathology, Professor, 医学部, 教授
1998 – 1999: 長崎大学, 医学部, 助教授
1996: 長崎大学, 医学部, 助教授
1994: 長崎大学, 医学部, 助教授
1993: 長崎大学, 医学部, 講師 Less
Review Section/Research Field
Principal Investigator
Basic Section 59040:Nutrition science and health science-related / Environmental physiology (including Physical medicine and Nutritional physiology) / Environmental physiology(including physical medicine and nutritional physiology) / Experimental pathology / Neuroscience in general / General internal medicine (including Psychosomatic medicine) / 老化(加齢) / Experimental pathology
Except Principal Investigator
Experimental pathology / Thoracic surgery … More / Experimental pathology / Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Basic Section 59040:Nutrition science and health science-related / Eating habits / Radiation science / Respiratory surgery Less
Keywords
Principal Investigator
老化 / カロリー制限 / カロリー制限模倣剤 / FoxO転写因子 / Aging / ミトコンドリア / 成長ホルモン / 海洋微生物抽出物 / 老化制御 / マクロファージ … More / Inflammasome / 炎症 / 発達・成長・老化 / フォークヘッド転写因子 / 癌 / Energy metabolism / Stress response / Insulin-like growth factor / Growth hormone / Insulin / Calorie-restriction / Longevity / エネルギー代謝 / ストレス応答 / インスリン様成長因子 / インスリン / 長寿 / Neuroendocrine / Leptin / Caloric restriction / 神経内分泌 / レプチン / マイクロRNA / 生活習慣病 / 代謝疾患 / Mi-RNA / バイオマーカー / microRNA / 老年医学 / Neuropeptide Y / TGF / bFGF / IGF-1 / 成長因子 / 下垂体 / カロリー / 食餌制限 / ラット下垂体 / Reverse Hemolytic Plague Assay … More
Except Principal Investigator
カロリー制限 / 老化 / IGF-1 / DNA chip / 白色脂肪組織 / 脂質代謝 / DNA array / トランスジェニックラット / 寿命延長 / penetrating aortic ulcer / 肺移植 / アディポネクチン / 脂肪組織 / SREBP1 / 寿命 / ミトコンドリアUPR / RNA-seq / マウス / サル / レスベラトロール / GDF15 / ミトコンドリアストレス応答 / ミトコンドリ生合成 / 脂肪酸生合成 / 脂肪萎縮 / 食餌誘導性肥満 / 長寿 / FoxO / Neuropeptide Y / エネルギー代謝 / 腫瘍抑制 / NPY / FOXO3 / FOXO1 / FMO3 / FMO / 生活習慣病 / 代謝 / インスリン感受性 / mTOR / WDR6 / 遺伝子改変動物 / オートファジー / 老化関連疾患 / インスリンシグナル / SREBP-1 / adipocytokine / white adipose tissue / insulin sensitivity / transgenic rats / growth hormone / calorie restriction / アディポサイトカイン / インシュリン感受性 / 成長ホルモン / liver / lipid metabolism / transgenic rat / Forkhead transcription factor / growth hormonef(GH)IGF-1 / calorie restriction(CR) / aging / 食餌制限 / 肝臓 / Forkhead転写因子 / GH / 食餌カロリー制限 / Atherosclerosis / Aortic aneurysm / Aortic dissection / 大動脈粥状硬化 / penetrating atherosclerotic ulcer / Spiral CT / Penetratind aortic ulcer / 大動脈硬化 / 大動脈瘤 / penetrating aertic ulcer / 大動脈解離 / バイオリアクター / マトリックス / 再細胞化 / 脱細胞化 / 組織工学 / 再生 / 肺 / 肺再生 / 脂肪肝細胞 / PARP阻害剤 / ラット肺移植 / 肺虚血再灌流 / PARP inhibitor / 脂肪幹細胞 / 虚血再灌流障害 / マイクロアレイ / 肺癌 / 肺気腫 / 小胞体ストレス / リポポリサッカライド / 炎症 / 細胞傷害 / LXR / SREBPI / ノックアウトマウス / ラット / 形態学的解析 / アセチルコリン・エステラーゼ / HNK-1 / 刺激伝導異常 / 未熟心 / 先天性心疾患 Less
  • Research Projects

    (22 results)
  • Research Products

    (171 results)
  • Co-Researchers

    (26 People)
  •  Search for compounds that mimic the effects of calorie restriction on healthy life extension and elucidation of mechanisms of the actionPrincipal Investigator

    • Principal Investigator
      下川 功
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      Nagasaki University
  •  Investigative research on the extention of healthy lifespan that can be applied to humans based on mitochondrial unfolded protein response

    • Principal Investigator
      Higami Yoshikazu
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
    • Review Section
      Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
    • Research Institution
      Tokyo University of Science
  •  Mechanisms underlying the anti-aging effect of calorie restriction: Roles for FoxO transcription factors in macrophagesPrincipal Investigator

    • Principal Investigator
      Shimokawa Isao
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      Nagasaki University
  •  Roles of FMO3 in aging and carcinogenesis under calorie restriction

    • Principal Investigator
      HAYASHI Hiroko
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      Nagasaki University
  •  Functional analysis of WDR6, a novel energy metabolism related gene

    • Principal Investigator
      CHIBA Takuya
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Eating habits
    • Research Institution
      Waseda University
  •  Regulation of cancer and aging by FoxO and investigation of compounds for regulation of FoxOPrincipal Investigator

    • Principal Investigator
      SHIMOKAWA Isao
    • Project Period (FY)
      2015 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Environmental physiology(including physical medicine and nutritional physiology)
    • Research Institution
      Nagasaki University
  •  Basic researches for the improvement of the fragility and the organ portection about de-and re-cellularization based regenerated lung

    • Principal Investigator
      TSUCHIYA Tomoshi
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Respiratory surgery
    • Research Institution
      Nagasaki University
  •  Calorie restriction associated microRNA: Possibility of biomarkers of human aging-dependent diseasesPrincipal Investigator

    • Principal Investigator
      SHIMOKAWA Isao
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      General internal medicine (including Psychosomatic medicine)
    • Research Institution
      Nagasaki University
  •  The study of tissue protection and cell implantation effects by adipose tissue derived stromal cells for future usage in damaged or transplanted lung

    • Principal Investigator
      TSUCHIYA Tomoshi
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Thoracic surgery
    • Research Institution
      Nagasaki University
  •  Regulation of the aging by calorie restriction: Implications of mitochondrial retrograde signalsPrincipal Investigator

    • Principal Investigator
      SHIMOKAWA Isao
    • Project Period (FY)
      2010 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Environmental physiology (including Physical medicine and Nutritional physiology)
    • Research Institution
      Nagasaki University
  •  The effects of adiponectin on lung cancer and lung disease

    • Principal Investigator
      TSUCHIYA Tomoshi
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Thoracic surgery
    • Research Institution
      Nagasaki University
  •  Mechanisms underlying the effect of calorie restriction : Analyses of neuropeptide Y and receptor subtypesPrincipal Investigator

    • Principal Investigator
      SHIMOKAWA Isao
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Environmental physiology (including Physical medicine and Nutritional physiology)
    • Research Institution
      Nagasaki University
  •  Suppressed cellular damage and inflammation, and altered metabolism by caloric restriction via SREBP1/LXR

    • Principal Investigator
      HIGAMI Yoshikazu
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Tokyo University of Science
  •  Investigation of genes involved in anti-obesity and insulin sensitivity in the white adipose tissue

    • Principal Investigator
      HIGAMI Yoshikazu
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Nagasaki University
  •  Regulation of aging in mammals : Difference between the effects of calorie restriction and suppression of the GH-IGF-1 axisPrincipal Investigator

    • Principal Investigator
      SHIMOAKAWA Isao
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Nagasaki University Graduate School of Biomedical Sciences
  •  What is the target of anti-aging action of calorie restriction?

    • Principal Investigator
      HIGAMI Yoshikazu
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Nagasaki University School of Medicine
  •  Mechanisms underlying the anti-aging effect of caloric restriction: A role for leptin in regulation of neuroendocrine systemPrincipal Investigator

    • Principal Investigator
      SHIMOKAWA Isao
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neuroscience in general
    • Research Institution
      NAGASAKI UNIVERSITY SCHOOL OF MEDICINE
  •  Clinical and basic research on the diagnosis and cause of aortic dissection

    • Principal Investigator
      HAYASHI Kuniaki
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Radiation science
    • Research Institution
      Nagasaki University
  •  食餌制限による下垂体前葉細胞の加齢、腫瘍化抑制機構-成長因子の関連性について-Principal Investigator

    • Principal Investigator
      下川 功
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      老化(加齢)
    • Research Institution
      Nagasaki University
  •  ラット先天性心疾患及び未熟児における刺激伝導異常の解析

    • Principal Investigator
      池田 高良
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Nagasaki University
  •  先天性刺激伝導異常の発生病理

    • Principal Investigator
      池田 高良
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Nagasaki University
  •  ラット下垂体前葉・Acidophilic cellの加齢変化と食餌制限の影響Principal Investigator

    • Principal Investigator
      下川 功
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Experimental pathology
    • Research Institution
      Nagasaki University

All 2024 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Other

All Journal Article Presentation Book Patent

  • [Book] HORMONES IN AGEING AND LONGEVITY2017

    • Author(s)
      Shimokawa I (eds. Rattan SIS and Sharma R
    • Total Pages
      10
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-15H04682
  • [Book] Hormones in Ageing and Longevity, Healthy Ageing and Longevity 62017

    • Author(s)
      Shimokawa I
    • Total Pages
      16
    • Publisher
      Springer International Publishing AG
    • Data Source
      KAKENHI-PROJECT-15H04682
  • [Book] 老化寿命のサイエンス 第5章 カロリー制限模倣物2013

    • Author(s)
      千葉 卓哉、下川 功
    • Total Pages
      8
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-24659351
  • [Book] 老化寿命のサイエンス第5章カロリー制限模倣物2013

    • Author(s)
      千葉 卓哉, 下川 功
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-22390042
  • [Book] 老化寿命のサイエンス第5章カロリー制限模倣物2013

    • Author(s)
      千葉卓哉、下川功
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-24659351
  • [Book] レスベラトロールの基礎と応用第7章サーチュインと老化,寿命2012

    • Author(s)
      下川 功, 千葉 卓哉, 森 亮一
    • Publisher
      シーエムシー出版
    • Data Source
      KAKENHI-PROJECT-22390042
  • [Book] レスベラトロールの基礎と応用第7章サーチュインと老化、寿命2012

    • Author(s)
      下川功、千葉卓哉、森亮一
    • Publisher
      シーエムシー出版
    • Data Source
      KAKENHI-PROJECT-24659351
  • [Book] Handbook on Immunosenescence2009

    • Author(s)
      Shimokawa I
    • Publisher
      Springer Science+Business Media B. V.
    • Data Source
      KAKENHI-PROJECT-19590227
  • [Book] A transgenic dwarf rat strain as a tool for the study of immunosenescence in aging rats and the effect of calorie restriction. In Handbook of Immunosenescence2009

    • Author(s)
      Shimokawa I, Utsuyama M, Komatsu T,Yamaza H, Chiba T, Fulop T et al.(Eds.)
    • Publisher
      Springer Science+ Business Media B.V.
    • Data Source
      KAKENHI-PROJECT-19590227
  • [Book] カロリー制限. 新老年学3版2009

    • Author(s)
      下川功, 大内尉義、他編
    • Publisher
      東京大学出版会
    • Data Source
      KAKENHI-PROJECT-19590227
  • [Book] 内分泌モデル(GH/IGF-I)動物「老化・老年病研究のための動物実験ガイドブック」2008

    • Author(s)
      千葉卓哉、山座治義、下川功
    • Publisher
      基礎老化学会編、アドスリー
    • Data Source
      KAKENHI-PROJECT-19590227
  • [Book] The somatotrophic axis in brain function(ed. Nyberg F.)2006

    • Author(s)
      Shimokawa I.
    • Publisher
      Elsevier Academic Press,
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Book] Handbook of Models for Human Aging (Chapter 31. A transgenic mini rat strain as a tool for studying aging and calorie restriction. P367-378)2006

    • Author(s)
      Shimokawa I
    • Total Pages
      1075
    • Publisher
      Elsevier Academic Press
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Book] Handbook for Models of Human Aging (Chapter 31 A transgenic mini rat strain as a tool for studying aging and calorie restriction)2006

    • Author(s)
      Shimokawa I (Conn M編集)
    • Publisher
      Academic Press
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Book] The Somatotropic Axis in Brain Function (Capter13. Rodent models for the study of the role of GH-IGF-1 or insulin axis in aging and longevity : Special reference to a transgenic dwarf rat strain and calorie restriction (p 173-184)2006

    • Author(s)
      Shimokawa I
    • Total Pages
      340
    • Publisher
      Elsevier Academic Press
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Book] Hand book for models of human aging(ed. Conn M,)2006

    • Author(s)
      Shimokawa I.
    • Publisher
      Elsevier Academic Press, Burlington, MA,
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Book] The somatotrophic axis in brain function (Chapter 14, Rodent models for the study of the role of GH-IGF-1 or the Insulin axis in aging and longevity : special reference to a transgenic dwarf rat2005

    • Author(s)
      Shimokawa I(Nyberg F編集)
    • Publisher
      Academic Press(印刷中)
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] Influence of Adipokines on Metabolic Dysfunction and Aging2024

    • Author(s)
      Park Seongjoon、Shimokawa Isao
    • Journal Title

      Biomedicines

      Volume: 12 Issue: 4 Pages: 873-873

    • DOI

      10.3390/biomedicines12040873

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K28021
  • [Journal Article] The Role of Neuropeptide Y in Adipocyte-Macrophage Crosstalk during High Fat Diet-Induced Adipose Inflammation and Liver Steatosis2021

    • Author(s)
      Park Seongjoon、Komatsu Toshimitsu、Hayashi Hiroko、Mori Ryoichi、Shimokawa Isao
    • Journal Title

      Biomedicines

      Volume: 9 Issue: 11 Pages: 1739-1739

    • DOI

      10.3390/biomedicines9111739

    • NAID

      120007188605

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21H04838, KAKENHI-PROJECT-19H04033, KAKENHI-PROJECT-20K20479
  • [Journal Article] Does Calorie Restriction Modulate Inflammaging via FoxO Transcription Factors?2020

    • Author(s)
      Kim Sang-Eun、Mori Ryoichi、Shimokawa Isao
    • Journal Title

      Nutrients

      Volume: 12 Issue: 7 Pages: 1959-1959

    • DOI

      10.3390/nu12071959

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K20479, KAKENHI-PROJECT-20K19640, KAKENHI-PROJECT-18H02962, KAKENHI-PROJECT-19H04033
  • [Journal Article] Mechanisms of Calorie Restriction: A Review of Genes Required for the Life-Extending and Tumor-Inhibiting Effects of Calorie Restriction2019

    • Author(s)
      Komatsu T, Park S, Hayashi H, Mori R, Yamaza H, Shimokawa I.
    • Journal Title

      Nutrients

      Volume: 11 Issue: 12 Pages: 1-18

    • DOI

      10.3390/nu11123068

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H04033
  • [Journal Article] NPY Deficiency Prevents Postmenopausal Adiposity by Augmenting Estradiol-Mediated Browning2018

    • Author(s)
      Park S, Nayantai E, Komatsu T, Hayashi H, Mori R, Shimokawa I.
    • Journal Title

      J Gerontol A Biol Sci Med Sci

      Volume: - Issue: 6 Pages: 1042-1049

    • DOI

      10.1093/gerona/gly282

    • NAID

      120006988174

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04682, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16H06277
  • [Journal Article] 基礎老化研究の展望:基礎老化学会が果たす役割2018

    • Author(s)
      下川 功
    • Journal Title

      老年医学

      Volume: 上 Pages: 51-56

    • Data Source
      KAKENHI-PROJECT-15H04682
  • [Journal Article] Neuropeptide Y resists excess loss of fat by lipolysis in calorie-restricted mice: A trait potential for the life-extending effect of calorie restriction2017

    • Author(s)
      Park S, Komatsu T, Kim SE, Tanaka K, Hayashi H, Mori R, Shimokawa I
    • Journal Title

      Aging Cell

      Volume: 16 Issue: 2 Pages: 339-348

    • DOI

      10.1111/acel.12558

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04682, KAKENHI-PROJECT-16H05493, KAKENHI-PROJECT-15K12342, KAKENHI-PROJECT-15K19517, KAKENHI-PROJECT-17K19917
  • [Journal Article] Comparing the Effects of Melatonin with Caloric Restriction in the Hippocampus of Aging Mice: Involvement of Sirtuin1 and the FOXOs Pathway2017

    • Author(s)
      Jenwitheesuk A, Park S, Wongchitrat P, Tocharus J, Mukda S, Shimokawa I, Govitrapong P
    • Journal Title

      Neurochem Res

      Volume: 43 Issue: 1 Pages: 144-152

    • DOI

      10.1007/s11064-017-2369-7

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04682
  • [Journal Article] FoxO1 signaling plays a pivotal role in the cardiac telomere biology responses to calorie restriction.2016

    • Author(s)
      Makino N, Oyama J, Maeda T, Koyanagi M, Higuchi Y, Shimokawa I, Mori N, Furuyama T.
    • Journal Title

      Mol Cell Biochem.

      Volume: 412 Issue: 1-2 Pages: 119-130

    • DOI

      10.1007/s11010-015-2615-8

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K08142, KAKENHI-PROJECT-15H04682, KAKENHI-PROJECT-15K08919, KAKENHI-PROJECT-15K14352
  • [Journal Article] The life-extending effect of dietary restriction requires Foxo3 in mice2015

    • Author(s)
      Shimokawa I, Komatsu T, Hayashi N, Kim SE, Kawata T, Park S, Hayashi H, Yamaza H, Chiba T, Mori R
    • Journal Title

      Aging Cell

      Volume: - Issue: 4 Pages: 707-707

    • DOI

      10.1111/acel.12340

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25560055, KAKENHI-PROJECT-15K12342, KAKENHI-PROJECT-15K19517, KAKENHI-PROJECT-15H04682, KAKENHI-PROJECT-25463187, KAKENHI-PROJECT-25282027, KAKENHI-PROJECT-24689069
  • [Journal Article] Caloric restriction-associated remodeling of rat white adepose tissue : effects on the growth hormone/insulin-like growth factor-1 axis, sterol regulatory element binding protein-1, and macrophage infiltration2013

    • Author(s)
      Chujo Y、Fujii N、Okita N、Konishi T、Yamada A、Haruyama Y、Tashiro K、Chiba T、Shimokawa I、Higami Y.
    • Journal Title

      Age(Dordr)

      Volume: Vol.35 Pages: 1143-1156

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659351
  • [Journal Article] Do sirtuins promote mammalian longevity? A critical review on its relevance to the longevity effect induced by calorie restriction2013

    • Author(s)
      Park S、Mori R、Shimokawa I.
    • Journal Title

      Mol Cells

      Volume: Vol.35 Pages: 474-480

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659351
  • [Journal Article] Primary hepatic gastrointestinal stromal tumor showing remarkable myxoid change and hemangiopericytoma-like pattern2013

    • Author(s)
      Hayashi H, Iseki M, Kawabata M, Nonoshita M, Yamamoto H, Shimokawa I
    • Journal Title

      Acta Medica Nagasakiensia

      Volume: Vol.58 Pages: 19-24

    • NAID

      110009577018

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390042
  • [Journal Article] Renoprotective effects of telmisartan after unilateral renal ablation in rats2013

    • Author(s)
      Matsuo T、Miyata Y、Sagara Y、Higami Y、Tobu S、Matsuo M、Noguchi M、Shimokawa I、Kanetake H、Sakai H.
    • Journal Title

      Int J Nephrol Renovasc

      Volume: Vol.6 Pages: 207-214

    • NAID

      120006986063

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659351
  • [Journal Article] Do sirtuins promote mammalian longevity? A critical review on its relevance to the longevity effect induced by calorie restriction2013

    • Author(s)
      Park S,Mori R,Shimokawa I
    • Journal Title

      Mol Cells

      Volume: Vol.35 Pages: 474-480

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390042
  • [Journal Article] Mechanisms of lifespan extension and preventive effects of calorie restriction on tumor development : Possible link between central neuroendocrine system and peripheral metabolic adaptation2013

    • Author(s)
      Chiba T、Dong K、Nishizono S、Shimokawa I.
    • Journal Title

      J Phys Fitness Sports Med

      Volume: Vol.2 Pages: 259-266

    • NAID

      10031179347

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659351
  • [Journal Article] Mechanisms of lifespan extension and preventive effects of calorie restriction on tumor development : Possible link between central neuroendocrine system and peripheral metabolic adaptation2013

    • Author(s)
      Chiba T,Dong K,Nishizono S, Shimokawa I
    • Journal Title

      J Phys Fitness Sports Med

      Volume: Vol.2 Pages: 259-266

    • NAID

      10031179347

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390042
  • [Journal Article] A case of intracystic apocrine papillary tumor : Diagnostic pitfalls for malignancy2013

    • Author(s)
      Hayashi H, Ohtani H, Yamaguchi J, Shimokawa I
    • Journal Title

      Pathol Res Pract

      Volume: Vol.209 Pages: 808-811

    • NAID

      120006986734

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390042
  • [Journal Article] Caloric restriction-associated remodeling of rat white adepose tissue : effects on the growth hormone/insulin-like growth factor-1 axis, sterol regulatory element binding protein-1, and macrophage infiltration2013

    • Author(s)
      Chujo Y,Fujii N,Okita N,Konishi T, Yamada A,Haruyama Y,Tashiro K,Chiba T,Shimokawa I,Higami Y
    • Journal Title

      Age(Dordr)

      Volume: Vol.35 Pages: 1143-1156

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390042
  • [Journal Article] Renoprotective effects of telmisartan after unilateral renal ablation in rats2013

    • Author(s)
      Matsuo T,Miyata Y,Sagara Y,Higami Y,Tobu S,Matsuo M,Noguchi M, Shimokawa I,Kanetake H,Sakai H
    • Journal Title

      Int J Nephrol Renovasc

      Volume: Vol.6 Pages: 207-214

    • NAID

      120006986063

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390042
  • [Journal Article] A case of intracystic apocrine papillary tumor : Diagnostic pitfalls for malignancy2013

    • Author(s)
      Hayashi H、Ohtani H、Yamaguchi J、Shimokawa I.
    • Journal Title

      Pathol Res Pract

      Volume: Vol.209 Pages: 808-811

    • NAID

      120006986734

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659351
  • [Journal Article] Do sirtuins promote mammalian longevity? A critical review on its relevance to the longevity effect induced by calorie restriction2013

    • Author(s)
      Park S, Mori R, Shimokawa I.
    • Journal Title

      Mol Cells. 2013 Jun;35(6):474-80

      Volume: 35 Issue: 6 Pages: 474-80

    • DOI

      10.1007/s10059-013-0130-x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390042
  • [Journal Article] Primary hepatic gastrointestinal stromal tumor showing remarkable myxoid change and hemangiopericytoma-like pattern2013

    • Author(s)
      Hayashi H、Iseki M、Kawabata M、Nonoshita M、Yamamoto H、Shimokawa I.
    • Journal Title

      Acta Medica Nagasakiensia

      Volume: Vol.58 Pages: 19-24

    • NAID

      110009577018

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659351
  • [Journal Article] Microcystic adnexal earcinomaの一例2012

    • Author(s)
      林洋子、井関充及、川崎辰彦、下川功
    • Journal Title

      診断病理

      Volume: Vol.029 Pages: 150-154

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659351
  • [Journal Article] M5総合病理CPC記録 : 慢性呼吸不全により死亡した31歳男性2012

    • Author(s)
      安井万里子、坂本光、新宮啓太、平光寿、高藤康、徳満純一、鳥山愛生、永田祐貴、難波夏実、道辻徹、高木理博、石田正之、有吉紅也、林洋子、下川功
    • Journal Title

      長崎医学会雑誌

      Volume: 87巻 Pages: 80-86

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659351
  • [Journal Article] Yamada K Hyperadiponectinemia protects against premature death in metabolic syndrome model mice by inhibiting AKT signaling and chronic inflammation2012

    • Author(s)
      Otabe S,Wada N,Hahinaga T,Yuan X Shimokawa I,Fukutani T,Tanaka K, Ohki T,Kakino S,Kurita Y,Nakayama H, Tajiri Y
    • Journal Title

      J Endocrinol

      Volume: Vol.213 Pages: 67-76

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390042
  • [Journal Article] カロリー制限とホルミシス2012

    • Author(s)
      下川 功
    • Journal Title

      日本抗加齢医学会雑誌

      Volume: Vol.8 Pages: 87-91

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390042
  • [Journal Article] Rodent Models to Study the Roles of the GH-IGF-1 Axis in the Aging and Anti-Aging Effects of Calorie Restriction2012

    • Author(s)
      Fang P, Tagliaro ML, Shimokawa I
    • Journal Title

      Open Endocrinol J

      Volume: Vol.6 Pages: 42-48

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390042
  • [Journal Article] Reporter bioassay systems for the phenotypic screening of candidate drugs2012

    • Author(s)
      Chiba T, Tsuchiya T, Mori R,Shimokawa I
    • Journal Title

      Sensors

      Volume: 12 Issue: 2 Pages: 1648-1656

    • DOI

      10.3390/s120201648

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23650484, KAKENHI-PROJECT-24659351
  • [Journal Article] Protein reporter bioassay systems for the phenotypic screening of candidate drugs: a mouse platform for anti-aging drug screening2012

    • Author(s)
      Chiba T, Tsuchiya T, Mori R, Shimokawa I
    • Journal Title

      Sensors (Basel)

      Volume: 12 Pages: 1648-1656

    • NAID

      120006985439

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390042
  • [Journal Article] Microcystic adnexal earcinomaの一例2012

    • Author(s)
      林 洋子, 井関 充及, 川崎 辰彦, 下川 功
    • Journal Title

      診断病理

      Volume: Vol.029 Pages: 150-154

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390042
  • [Journal Article] カロリー制限とホルミシス2012

    • Author(s)
      下川功
    • Journal Title

      日本抗加齢医学会雑誌

      Volume: Vol.8 Pages: 87-91

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659351
  • [Journal Article] Hyperadiponectinemia protects against premature death in metabolic syndrome model mice by inhibiting AKT signaling and chronic inflammation2012

    • Author(s)
      Otabe S、Wada N、Hahinaga T、Yuan X Shimokawa I、Fukutani T、Tanaka K、Ohki T、Kakino S、Kurita Y、Nakayama H、Tajiri Y、Yamada K.
    • Journal Title

      J Endocrinol

      Volume: Vol.213 Pages: 67-76

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659351
  • [Journal Article] Protein reporter bioassay systems for the phenotypic screening of candidate drugs : a mouse platform for anti-aging drug screening2012

    • Author(s)
      Chiba T,Tsuchiya T,Mori R, Shimokawa I
    • Journal Title

      Sensors(Basel)

      Volume: Vol.12 Pages: 1648-1656

    • NAID

      120006985439

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390042
  • [Journal Article] Hyperadipo-nectinemia protects against premature death in metabolic syndrome model mice by inhibiting AKT signaling and chronic inflammation2012

    • Author(s)
      Otabe S, Wada N, Hashinaga T, Yuan X, Shimokawa I, FukutaniT, Tanaka K, Ohki T, Kakino S, Kurita Y, Nakayama H, Tajiri Y, Yamada K
    • Journal Title

      Journal of Endocrinology

      Volume: 213 Issue: 1 Pages: 67-76

    • DOI

      10.1530/joe-11-0329

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591154, KAKENHI-PROJECT-22390042, KAKENHI-PROJECT-24659351
  • [Journal Article] Rodent Models to Study the Roles of the GH-IGF-1 Axis in the Aging and Anti-Aging Effects of Calorie Restriction2012

    • Author(s)
      Fang P、Tagliaro ML、Shimokawa I.
    • Journal Title

      Open Endocrinol J

      Volume: Vol.6 Pages: 42-48

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659351
  • [Journal Article] Protein reporter bioassay systems for the phenotypic screening of candidate drugs : a mouse platform for anti-aging drug screening2012

    • Author(s)
      Chiba T、Tsuchiya T、Mori R、Shimokawa I.
    • Journal Title

      Sensors(Basel)

      Volume: Vol.12 Pages: 1648-1656

    • NAID

      120006985439

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659351
  • [Journal Article] M5総合病理CPC 記録 : 慢性呼吸不全により死亡した31歳男性2012

    • Author(s)
      安井 万里子, 坂本 光, 新宮 啓太, 平 光寿, 高藤 康, 徳満 純一, 鳥山 愛生, 永田 祐貴, 難波 夏実, 道辻 徹, 高木 理博, 石田 正之, 有吉 紅也, 林 洋子, 下川 功
    • Journal Title

      長崎医学会雑誌

      Volume: 87巻 Pages: 80-86

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390042
  • [Journal Article] Modest inhibition of the growth hormone axis does not affect mitochondrial reactive oxygen species generation or redox state, unlike calorie restriction2011

    • Author(s)
      Hayashida T, Shimokawa I, 他
    • Journal Title

      Geriatr Gerontol Int

      Volume: 11 Issue: 4 Pages: 496-503

    • DOI

      10.1111/j.1447-0594.2011.00692.x

    • NAID

      10030468628

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390042
  • [Journal Article] Modest inhibition of the growth hormone axis does not affect mitochondrial reactive oxygen species generation or redox state, unlike calorie restriction.2011

    • Author(s)
      Hayashida T, Shimokawa I, 他
    • Journal Title

      Geriatr Gerontol Int

      Volume: (印刷中)

    • NAID

      10030468628

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390042
  • [Journal Article] Pカロリー制限の抗老化効果2011

    • Author(s)
      下川功
    • Journal Title

      消化器内科

      Volume: 53 Pages: 258-263

    • Data Source
      KAKENHI-PROJECT-22390042
  • [Journal Article] 老化の基本メカニズムとアンチエイジング2009

    • Author(s)
      下川功
    • Journal Title

      日本臨床 (印刷中)

    • Data Source
      KAKENHI-PROJECT-19590227
  • [Journal Article] カロリー制限の抗老化機構2009

    • Author(s)
      下川功
    • Journal Title

      細胞 (印刷中)

    • Data Source
      KAKENHI-PROJECT-19590227
  • [Journal Article] Manipulation of caloric content but not diet composition, attenuates the deficit in learning and memory of senescence-ccelerated mouse strain P82008

    • Author(s)
      Komatsu T, Chiba T, Yamaza H, Yamashita K, Shimada A, Hoshiyama Y, Henmi T, Ohtani H, Higami Y, de Cabo R, Ingram DK, Shimokawa I
    • Journal Title

      Exp Gerontol 43(4)

      Pages: 339-46

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590227
  • [Journal Article] Calorie restriction minimizes activation of insulin signaling in response to glucose : potential involvement of the growth hormone-insulin-like growth factor 1 axis2008

    • Author(s)
      Hayashi H, Yamaza H, Komatsu T, Park S, Chiba T, Higami Y, Nagayasu T, Shimokawa I
    • Journal Title

      Exp Gerontol 43(9)

      Pages: 827-32

    • NAID

      120006981679

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590227
  • [Journal Article] カロリー制限と老化2008

    • Author(s)
      千葉卓哉、山座治義、下川功
    • Journal Title

      Surgery Frontier 2008 15

      Pages: 36-40

    • Data Source
      KAKENHI-PROJECT-19590227
  • [Journal Article] Genet ic suppression of GH-IGF-1 activity, combined with lifelong caloric restri-ction, prevents age-related renal damage and prolongs the life span in rats2008

    • Author(s)
      Zha Y, Taguchi T, Nazneen A, Shimokawa I, Higami Y, Razzaque MS
    • Journal Title

      Am J Nephrol 28(5)

      Pages: 755-64

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590227
  • [Journal Article] Longevity genes : insights from calorie restriction and genetic longevity models2008

    • Author(s)
      Shimokawa I, Chiba T, Yamaza H, Komatsu T
    • Journal Title

      Mol Cells 30 ; 26(5)

      Pages: 427-35

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590227
  • [Journal Article] Pituitary growth hormone suppression reduces resistin expression and enhances insulin effectiveness : relationship with caloric restriction2008

    • Author(s)
      Chiba T, Yamaza H, Komatsu T, Nakayama M, Fujita S, Hayashi H, Higami Y, Shimokawa I
    • Journal Title

      Exp Gerontol 43(6)

      Pages: 595-600

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590227
  • [Journal Article] カロリー制限による寿命延長・抗老化機構-神経内分泌仮説に基づく代謝調節の重要性-2008

    • Author(s)
      千葉卓哉、山座治義、下川功
    • Journal Title

      基礎老化研究 Vol.32, No.3

      Pages: 15-20

    • NAID

      10024377776

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590227
  • [Journal Article] Longevity genes : insights from calorie restriction and genetic longevity models.2008

    • Author(s)
      Shimokawa I.
    • Journal Title

      Molecules & Cells 26

      Pages: 427-435

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590227
  • [Journal Article] Identification of fasting-induced genes in the rat hypothalamus : relationship with neuroprotection2007

    • Author(s)
      Chiba T, Fujita S, Kubota H, Inoue D, Mizuno A, Komatsu T, Yamaza H, Higami Y, Shimokawa I
    • Journal Title

      Ann N Y Acad Sci. 1119

      Pages: 216-26

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590227
  • [Journal Article] Down-regulation of AMP-activated protein kinase by calorie restriction in rat liver2007

    • Author(s)
      To K, Yamaza H, Komatsu T, Hayashida T, Hayashi H, Toyama H, Chiba T, Higami Y, Shimokawa I
    • Journal Title

      Exp Gerontol 42(11)

      Pages: 1063-71

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590227
  • [Journal Article] Involvement of insulin-like growth factor-1 in the effect of caloric restriction : regulation of plasma adiponectin and leptin2007

    • Author(s)
      Yamaza H, Komatsu T, To K, Toyama H, Chiba T, Higami Y, Shimokawa I
    • Journal Title

      J Gerontol A Biol Sci Med Sci. 62(1)

      Pages: 27-33

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590227
  • [Journal Article] Calorie restriction/Healthy aging (in Japanese)2006

    • Author(s)
      Shimokawa I.
    • Journal Title

      Gerontology New Horizon 18

      Pages: 23-27

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] Role of leptin signaling in the hypothalamus in the effect of calorie restriction2006

    • Author(s)
      Komatsu T, Chiba T, Yamaza H, To K, Toyama H, Higami Y, Shimokawa I.
    • Journal Title

      J Gerontol : Bio Sci (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] カロリー制限/健康加齢2006

    • Author(s)
      下川 功
    • Journal Title

      ジェロントロジー ニューホライズン 18

      Pages: 23-27

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] Molecular mechanisms underlying the life-prolonging effect of CR (in Japanese)2006

    • Author(s)
      Chiba T, Shimokawa I.
    • Journal Title

      Igaku-no-ayumi (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] カロリー制限とアンチエイジング2005

    • Author(s)
      下川 功
    • Journal Title

      アンチエイジング医学(日本抗加齢医学会雑誌) 1

      Pages: 164-168

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] Laboratory findings of caloric restriction in rodents and primates.2005

    • Author(s)
      Higami Y, Yamaza H, Shimokawa I.
    • Journal Title

      Adv Clin Chem. 39

      Pages: 211-237

    • Data Source
      KAKENHI-PROJECT-16590317
  • [Journal Article] Acute stress response in calorie-restricted rats to lipopolysaccharide-Induced inflammation2005

    • Author(s)
      Tsuchiya T, Higami Y, Komatsu T, Tanaka K, Honda S, Yamaza H, Chiba T, Ayabe H, Shimokawa I.
    • Journal Title

      Mech Ageing and Develop 126

      Pages: 568-579

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] Acute stress response in calorie-restricted rats to lipopolysaccharide-induced inflammation.2005

    • Author(s)
      Tsuchiya T, Higami Y, Komatsu T, Tanaka K, Honda S, Yamaza H, Chiba T, Ayabe H, Shimokawa I
    • Journal Title

      Mech Ageing Dev 126

      Pages: 568-579

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590317
  • [Journal Article] Glucose metabolism in calorie-restricted or transgenic dwarf rat : Analysis of adiponectin-AMPK pathway (in Japanese)2005

    • Author(s)
      Hayashi H, Yamaza H, Tou K, Toyama H, Komatsu T, Chiba T, Higami Y, Shimokawa I.
    • Journal Title

      Biomedical Gerontology 29

      Pages: 31-34

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] カロリー制限とアンチエイジング2005

    • Author(s)
      下川 功
    • Journal Title

      日本抗加齢医学会雑誌 1

      Pages: 24-28

    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] Laboratory findings of caloric restriction in rodents and primates2005

    • Author(s)
      Higami Y, Yamaza H, Shimokawa I.
    • Journal Title

      Adv Clin Chem 39

      Pages: 211-237

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] Glucose-insulin system in long-lived rats ; effects of calorie restriction and suppression of GH-IGF-1 axis (in Japanese)2005

    • Author(s)
      Yamaza H, Komatsu T, Higami Y, Shimokawa I.
    • Journal Title

      Biomedical Gerontology

      Pages: 25-29

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] Laboratory findings of caloric restriction in rodents and primates.2005

    • Author(s)
      Higami Y, Shimokawa I, Yamaza H
    • Journal Title

      Adv Clin Chem 39

      Pages: 211-237

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590317
  • [Journal Article] Calorie restriction and anti-aging (in Japanese)2005

    • Author(s)
      Shimokawa I.
    • Journal Title

      Anti-aging Medicine 1

      Pages: 164-168

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] 酸化ストレスとカロリー制限-Oxidative stress and calorie restriction2004

    • Author(s)
      下川 功
    • Journal Title

      ジェロントロジー ニューホライズン 16

      Pages: 207-210

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] 長寿と摂取カロリー制限2004

    • Author(s)
      下川 功
    • Journal Title

      日本医事新報 4183

      Pages: 95-96

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] Altered lipid metabolism in rodents animals subjected to caloric restriction2004

    • Author(s)
      Higami Y, Weindruch R, Prolla TA, Shimokawa I
    • Journal Title

      Geriatrics Gerontol Int, 4

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] A transgenic dwarf rat model as a tool for the study of calorie restriction and aging.2004

    • Author(s)
      Yamaza H, Komatsu T, Chiba T, Toyama H, To K, Higami Y, Shimokawa I.
    • Journal Title

      Exp Gerontol 39

      Pages: 269-272

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] カロリー制限と寿命2004

    • Author(s)
      下川 功
    • Journal Title

      科学 11

      Pages: 1409-1413

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] Expression of DNase gamma during Fas-independent apoptotic DNA fragmentation in rodent hepatocytes2004

    • Author(s)
      Higami Y, Tsuchiya T, To K, Chiba T, Yamaza H, Shiokawa D, Tanuma S, Shimokawa I.
    • Journal Title

      Cell Tissue Res, 316

      Pages: 403-407

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] Oxidative stress and calorie restriction2004

    • Author(s)
      Shimokawa I
    • Journal Title

      Geriatrics Gerontology International 4

    • NAID

      10018027453

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] Aging increases DNase γ, an apoptosis-related endonuclease, in rat liver nuclei : effect of dietary restriction.2004

    • Author(s)
      Tanaka K, Higami Y, Tsuchiya T, Shiokawa D1, Tanuma S1, Ayabe H2, Shimokawa I.
    • Journal Title

      Exp Gerontol 39

      Pages: 195-202

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] Oxidative stress and calorie restriction2004

    • Author(s)
      Shimokawa I.
    • Journal Title

      Geriat Geront Int 4

    • NAID

      10018027453

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] Calorie restriction and lifespan (in Japanese)2004

    • Author(s)
      Shimokawa I.
    • Journal Title

      Science Journal Kagaku 11

      Pages: 1409-1413

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] Oxidative stress and calorie restriction (in Japanese)2004

    • Author(s)
      Shimokawa I.
    • Journal Title

      Gerontology New Horizon 16

      Pages: 207-210

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] Longevity and calorie restriction (in Japanese)2004

    • Author(s)
      Shimokawa I.
    • Journal Title

      Japan Medical Journal 4183

      Pages: 95-96

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] カロリー制限と寿命2004

    • Author(s)
      下川 功
    • Journal Title

      科学 74

      Pages: 1409-1413

    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] Effects of caloric restriction on gene expression in the arcuate nucleus.2003

    • Author(s)
      Shimokawa I, Fukuyama T, Yanagihara-Outa K, Tomita M, Komatsu T, Higami Y, Tsuchiya T, Chiba T, Yamaza H.
    • Journal Title

      Neurobiol Aging, 24

      Pages: 117-123

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] Effects of caloric restriction on gene expression in the arcuate nucleus2003

    • Author(s)
      Shimokawa I
    • Journal Title

      Neurobiology of Aging 24

      Pages: 117-123

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] Life span extension by reduction of the growth hormone-insulin-like growth factor-1 axis : relation to caloric restriction.2003

    • Author(s)
      Shimokawa I, Higami Y, Tsuchiya T, Otani H, Komatsu T, Chiba T, Yamaza H.
    • Journal Title

      FASEB J, 17

      Pages: 1108-1109

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] Lifespan extension by reduction of the growth hormone-insulin-like growth factor-1 axis : relation to calorie restriction2003

    • Author(s)
      Shimokawa I
    • Journal Title

      FASEB J 17

      Pages: 1108-1109

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] Hepatic gene expression profile of lipid metabolism in rats : impact of caloric restriction and growth hormone/IGF-1 suppression.

    • Author(s)
      Higami Y, Tsuchiya T, Chiba T, Yamaza H, Muraoka I, Hirose M, Komatsu T, Shimokawa I
    • Journal Title

      J Gerontol A Biol Sci Med Sci (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590317
  • [Journal Article] Effect of leptin on hypothalamic gene expression in calorie-restricted rats.

    • Author(s)
      Komatsu T, Chiba T, Yamaza H, To K, Toyama H, Higami Y, Isao Shimokawa I
    • Journal Title

      J Gerontol A Biol Sci Med Sci (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590317
  • [Patent] 寿命延長関連遺伝子およびその用途2007

    • Inventor(s)
      千葉卓哉、下川功、樋上賀一、山座治義
    • Industrial Property Rights Holder
      国立大学法人長崎大学
    • Industrial Property Number
      2007-061075
    • Filing Date
      2007-03-07
    • Data Source
      KAKENHI-PROJECT-19590227
  • [Presentation] Mechanisms underlying the life-extending effect of dietary energy restriction2021

    • Author(s)
      Shimokawa I
    • Organizer
      First Joint Event between SixERS and UST
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H04033
  • [Presentation] ほ乳類の老化制御機構と心疾患研究2021

    • Author(s)
      下川 功
    • Organizer
      CVMW2021心血管代謝週間
    • Data Source
      KAKENHI-PROJECT-19H04033
  • [Presentation] FoxO3 regulates energy metabolism and metabolic disorders in aging animals2021

    • Author(s)
      Shimokawa I
    • Organizer
      Wild Ginseng Anti-aging Expo
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H04033
  • [Presentation] カロリー制限研究の歴史と展望2020

    • Author(s)
      下川 功
    • Organizer
      日本基礎老化学会 第一回市民フォーラム in 松本
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H04033
  • [Presentation] カロリー制限による老化制御機構2018

    • Author(s)
      下川 功
    • Organizer
      第29回 フォーラム・イン・ドージン、2018年11月22日、熊本
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H04682
  • [Presentation] ほ乳類の老化制御機構2018

    • Author(s)
      下川 功
    • Organizer
      第70回西日本泌尿器科学会総会、2018年11月2日、長崎
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H04682
  • [Presentation] WDR6 knock down affects LC3 expression in mammarian cell: possible involvment in the autophagy pathway2018

    • Author(s)
      Yoshihisa OHATA, ZI WANG, Yukari WATANABE, Shoko NISHIZONO, Toshimitsu KOMATSU, Isao SHIMOKAWA, Takuya CHIBA
    • Organizer
      第41回日本基礎老化学会大会
    • Data Source
      KAKENHI-PROJECT-15K12349
  • [Presentation] 新規インスリン関連分子WDR6がオートファジー経路に与える影響の解析2018

    • Author(s)
      大畑佳久、王梓、渡辺由香里、西園祥子、小松利光、下川功、千葉卓哉
    • Organizer
      第18回日本抗加齢医学会
    • Data Source
      KAKENHI-PROJECT-15K12349
  • [Presentation] Roles for FoxO transcription factors in the anti-aging effect of dietary restriction2018

    • Author(s)
      Shimokawa I
    • Organizer
      The 12th International Symposium for Aging (2-3 November, 2018, Gwangju, Korea)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04682
  • [Presentation] Differential roles for FoxO1 and FoxO3 in regulation of cancer and lifespan in dietary-restricted mice2017

    • Author(s)
      Shimokawa I
    • Organizer
      The 21st IAGG World Congress of Gerontology and Geriatrics
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04682
  • [Presentation] Insulin/IGF-I-mTORC1経路におけるWD repeat protein 6の役割2016

    • Author(s)
      大畑佳久、王梓、芹澤愼一郎、熊谷真帆、下川功、千葉卓哉
    • Organizer
      第16回日本抗加齢医学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-06-10
    • Data Source
      KAKENHI-PROJECT-15K12349
  • [Presentation] Anti-Ageing Effect of Dietary Restriction2016

    • Author(s)
      Shimokawa I
    • Organizer
      Biomembrane 2016: Mechanisms of aging and age-related diseases
    • Place of Presentation
      Moscow, Rossia
    • Year and Date
      2016-09-26
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04682
  • [Presentation] Insulin/IGF-I-mTORC1経路におけるWD repeat protein 6の役割2016

    • Author(s)
      大畑佳久、王梓、芹澤愼一郎、熊谷真帆、下川功、千葉卓哉
    • Organizer
      日本抗加齢医学会
    • Place of Presentation
      横浜
    • Year and Date
      2016-06-10
    • Data Source
      KAKENHI-PROJECT-15K12349
  • [Presentation] Distinct roles of Foxo1 and Foxo3 in the anti-neoplastic and the life-extending effects of dietary restriction-Implication of Foxo3 in regulation of mitochondrial integrity during the aging process2015

    • Author(s)
      Shimokawa I
    • Organizer
      The 2015 Cold Spring Harbor Asia Conference
    • Place of Presentation
      Suzhou, China
    • Year and Date
      2015-09-14
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04682
  • [Presentation] Upregulation of cytochrome c oxidase subunit 6b1 enhances mitochondrial respiration and oxidative stress response: Possible implication in the anti-aging effect of calorie restriction2014

    • Author(s)
      Sang Eun Kim, Ryoichi Mori, Toshimitsu Komatsu, Takuya Chiba, Hiroko Hayashi, Michiru D. Sugawa, Norbert A. Dencher and Isao Shimokawa
    • Organizer
      The 4th Busan-Nagasaki Joint Symposium on Ageng Research, Busan
    • Place of Presentation
      Busan, Korea
    • Data Source
      KAKENHI-PROJECT-22390042
  • [Presentation] Longevity genes; an update2014

    • Author(s)
      Shimokawa I
    • Organizer
      The 4th Busan-Nagasaki Joint Symposium on Aging Research
    • Place of Presentation
      Busan
    • Year and Date
      2014-02-21
    • Data Source
      KAKENHI-PROJECT-22390042
  • [Presentation] Longevity genes; an update2014

    • Author(s)
      Shimokawa I.
    • Organizer
      The 4^<th> Busan-Nagasaki Joint Symposium on Aging Research
    • Place of Presentation
      Busan
    • Year and Date
      2014-02-21
    • Data Source
      KAKENHI-PROJECT-24659351
  • [Presentation] A novel role of neuroprptide Y in mammalian aging : Linking calorie restriction to longevity2013

    • Author(s)
      Shimokawa I.
    • Organizer
      The 20^<th> World Congress of Gerontology and Geriatrics
    • Place of Presentation
      Seoul
    • Data Source
      KAKENHI-PROJECT-24659351
  • [Presentation] A key role for neuropeptide Y in lifespan extension and cancer suppression via dietary restriction2013

    • Author(s)
      Shimokawa I.
    • Organizer
      Asian Association of Aging Research-2013 Seoul Symposium
    • Place of Presentation
      Seoul
    • Data Source
      KAKENHI-PROJECT-24659351
  • [Presentation] カロリスにおけるニューロペプチドY の役割2013

    • Author(s)
      下川 功
    • Organizer
      第13回日本抗加齢医学会総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-22390042
  • [Presentation] A novel role of neuroprptide Y in mammalian aging : Linking calorie restriction to longevity2013

    • Author(s)
      Shimokawa I
    • Organizer
      The 20th World Congress of Gerontology and Geriatrics
    • Place of Presentation
      Seoul
    • Data Source
      KAKENHI-PROJECT-22390042
  • [Presentation] カロリー制限の寿命延長、腫瘍抑制効果におけるNeuropeptideYの役割2013

    • Author(s)
      下川功
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-24659351
  • [Presentation] Differential regulation of cancer and lifespan by dietary restriction via FoxO1 and FoxO3、Asian Aging 20132013

    • Author(s)
      Shimokawa I.
    • Organizer
      Japan-Korea Joint Conference on Genes, Metabolism, and Neurodegeneration
    • Place of Presentation
      Kyoto
    • Data Source
      KAKENHI-PROJECT-24659351
  • [Presentation] A contrast between roles for FoxO1 and FoxO3 in cencer suppression and lifespan extension by dietary restriction in mice2013

    • Author(s)
      Shimokawa I
    • Organizer
      The 4th East Asia-West Pacific Region Workshop on Aging Society and Elderly Care
    • Place of Presentation
      Tokyo
    • Year and Date
      2013-06-22
    • Data Source
      KAKENHI-PROJECT-22390042
  • [Presentation] A key role for neuropeptide Y in lifespan extension and cancer suppression via dietary restriction2013

    • Author(s)
      Shimokawa I
    • Organizer
      Asian Association of Aging Research-2013 Seoul Symposium
    • Place of Presentation
      Seoul
    • Data Source
      KAKENHI-PROJECT-22390042
  • [Presentation] Differential regulation of cancer and lifespan by dietary restriction via FoxO1 and FoxO32013

    • Author(s)
      Shimokawa I
    • Organizer
      Cold Spring Harbor Conferences Asia
    • Place of Presentation
      China
    • Data Source
      KAKENHI-PROJECT-22390042
  • [Presentation] カロリスにおけるニューロペプチドYの役割2013

    • Author(s)
      下川功
    • Organizer
      第13回日本抗加齢医学会総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-24659351
  • [Presentation] Differential regulation of cancer and lifespan by dietary restriction via FoxO1 and FoxO32013

    • Author(s)
      Shimokawa I
    • Organizer
      Asian Aging 2013 : Japan-Korea Joint Conference on Genes, Metabolism, and Neurodegeneration
    • Place of Presentation
      Kyoto
    • Data Source
      KAKENHI-PROJECT-22390042
  • [Presentation] Differential regulation of cancer and lifespan by dietary restriction via FoxO1 and FoxO32013

    • Author(s)
      Shimokawa I.
    • Organizer
      Cold Spring Harbor Conferences Asia
    • Place of Presentation
      China
    • Data Source
      KAKENHI-PROJECT-24659351
  • [Presentation] Differential regulation of cancer and lifespan by dietary restriction via FoxO1 and FoxO32013

    • Author(s)
      Shimokawa I
    • Organizer
      2013 Mini-Symposium on Mitochondria and Aging
    • Place of Presentation
      Taipei
    • Year and Date
      2013-10-19
    • Data Source
      KAKENHI-PROJECT-22390042
  • [Presentation] Differential regulation of cancer and lifespan by dietary restriction via FoxO1 and FoxO32013

    • Author(s)
      Shimokawa I.
    • Organizer
      2013 Mini-Symposium on Mitochondria and Aging
    • Place of Presentation
      Taipei
    • Year and Date
      2013-10-19
    • Data Source
      KAKENHI-PROJECT-24659351
  • [Presentation] A contrast between roles for FoxO1 and FoxO3 in cencer suppression and lifespan extension by dietary restriction in mice2013

    • Author(s)
      Shimokawa I.
    • Organizer
      The 4^<th> East Asia-West Pacific Region Workshop on Aging Society and Elderly Care
    • Place of Presentation
      Tokyo
    • Year and Date
      2013-06-22
    • Data Source
      KAKENHI-PROJECT-24659351
  • [Presentation] カロリー制限の寿命延長, 腫瘍抑制効果におけるNeuropeptideY の役割2013

    • Author(s)
      下川 功
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-22390042
  • [Presentation] Modulators of neuropeptide Y; potential dietary restriction mimetics2012

    • Author(s)
      Shimokawa I.
    • Organizer
      The 2^<nd> Pusan-Nagasaki joint Seminar on Aging Research
    • Place of Presentation
      Pusan
    • Year and Date
      2012-02-17
    • Data Source
      KAKENHI-PROJECT-24659351
  • [Presentation] A potential role for Cox6b1, a subunit of mitochondrial respiratory complex IV, in the effect of dietary restriction2012

    • Author(s)
      Shimokawa I
    • Organizer
      The 4th Hallym-Nagasaki-Extended Joint Meeting
    • Place of Presentation
      ソウル、韓国(招待講演)
    • Year and Date
      2012-02-28
    • Data Source
      KAKENHI-PROJECT-22390042
  • [Presentation] A potential role for COX6B1, a subunit of mitochondrial respiratory complex IV, in the effect of dietary restriction2012

    • Author(s)
      Shimokawa I
    • Organizer
      2012 Spring Conference of the Korean Society for Gerontology and the 11th Korea-Japan Gerontologist Joint meeting
    • Place of Presentation
      Osong, Korea
    • Invited
    • Data Source
      KAKENHI-PROJECT-22390042
  • [Presentation] Necessity of Neuropeptide Y for the Effect of Dietary Restriction in Mice2012

    • Author(s)
      Shimokawa I
    • Organizer
      The 65th Annual Meeting of Gerontological Society of America
    • Place of Presentation
      San Diego
    • Data Source
      KAKENHI-PROJECT-22390042
  • [Presentation] Dbf4はATM/ATRによって直接制御されるチェックポイントタンパクとして機能している2012

    • Author(s)
      下川功
    • Organizer
      第35回日本基礎老化学会
    • Place of Presentation
      千葉
    • Data Source
      KAKENHI-PROJECT-24659351
  • [Presentation] A potential role for COX6B1, a subunit of mitochondrial respiratory complex IV, in the effect of dietary restriction2012

    • Author(s)
      Shimokawa I
    • Organizer
      The 4th Hallym-Nagasaki-Exetended Joint Meeting, Aging, Re-generation and Re-construction
    • Place of Presentation
      Seoul
    • Year and Date
      2012-02-28
    • Data Source
      KAKENHI-PROJECT-22390042
  • [Presentation] 「FoxOとカロリー制限」2012

    • Author(s)
      下川 功
    • Organizer
      シンポジウム「中庸の徳~インスリンシグナルと寿命,疾患」, 第12回日本抗加齢医学会総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-22390042
  • [Presentation] 「FoxOとカロリー制限」inシンポジウム「中庸の徳〜インスリンシグナルと寿命、疾患」2012

    • Author(s)
      下川功
    • Organizer
      第12回日本抗加齢医学会総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-24659351
  • [Presentation] Necessity of Neuropeptide Y for the Effect of Dietary Restriction in Mice2012

    • Author(s)
      Shimokawa I.
    • Organizer
      The 65^<th> Annual Meeting of Gerontological Society of America
    • Place of Presentation
      San Diego
    • Data Source
      KAKENHI-PROJECT-24659351
  • [Presentation] The necessity of neuropeptide Y in the effect of dietary restriction in mice,Keystone Symposia2012

    • Author(s)
      Shimokawa I
    • Organizer
      Aging and Diseases of Aging
    • Place of Presentation
      Tokyo
    • Data Source
      KAKENHI-PROJECT-22390042
  • [Presentation] potential dietary restriction mimetics2012

    • Author(s)
      Shimokawa I , Modulators of neuropeptide Y
    • Organizer
      The 2nd Pusan-Nagasaki joint Seminar on Aging Research
    • Place of Presentation
      Pusan
    • Year and Date
      2012-02-17
    • Data Source
      KAKENHI-PROJECT-22390042
  • [Presentation] Differential regulation of cancer and lifespan by dietary restriction through FoxO1 and FoxO32012

    • Author(s)
      Shimokawa I.
    • Organizer
      International Symposium of Asian Association of Aging Research 2012 in Fukuoka-Biology of Aging and Disorders
    • Place of Presentation
      Fukuoka
    • Data Source
      KAKENHI-PROJECT-24659351
  • [Presentation] The necessity of neuropeptide Y in the effect of dietary restriction in mice、Keystone Symposia2012

    • Author(s)
      Shimokawa I.
    • Organizer
      Aging and Diseases of Aging
    • Place of Presentation
      Tokyo
    • Data Source
      KAKENHI-PROJECT-24659351
  • [Presentation] The necessity of neuropeptide Y in the effect of dietary restriction in mice2012

    • Author(s)
      Shimokawa I, Chiba T, Park S, Komatsu T, Chung H, Mori R, Kusudo T, Yamashita H, Park D
    • Organizer
      Keystone Symposia, Aging and Diseases of Aging
    • Place of Presentation
      Tokyo
    • Data Source
      KAKENHI-PROJECT-24659351
  • [Presentation] Differential regulation of cancer and lifespan by dietary restriction through FoxO1 and FoxO32012

    • Author(s)
      Shimokawa I
    • Organizer
      International Symposium of Asian Association of Aging Research 2012 in Fukuoka-Biology of Aging and Disorders-
    • Place of Presentation
      Fukuoka
    • Data Source
      KAKENHI-PROJECT-22390042
  • [Presentation] A potential role for COX6B1, a subunit of mitochondrial respiratory complex IV, in the effect of dietary restriction2012

    • Author(s)
      Shimokawa I.
    • Organizer
      2012 Spring Conference of the Korean Society for Gerontology and the 11^<th> Korea-Japan Gerontologist Joint Meeting
    • Place of Presentation
      Osong
    • Data Source
      KAKENHI-PROJECT-24659351
  • [Presentation] A potential role for COX6B1, a subunit of mitochondrial respiratory complex IV, in the effect of dietary restriction2012

    • Author(s)
      Shimokawa I
    • Organizer
      2012 Spring Conference of the Korean Society for Gerontology and the 11th Korea-Japan Gerontologist Joint Meeting
    • Place of Presentation
      Osong
    • Data Source
      KAKENHI-PROJECT-22390042
  • [Presentation] A potential role for COX6B1, a subunit of mitochondrial respiratory complex IV, in the effect of dietary restriction2012

    • Author(s)
      Shimokawa I.
    • Organizer
      The 4^<th> Hallym-Nagasaki-Exetended Joint Meeting, Aging, Re-generation and Re-construction
    • Place of Presentation
      Seoul
    • Year and Date
      2012-02-28
    • Data Source
      KAKENHI-PROJECT-24659351
  • [Presentation] A potential role for COX6B1, a subunit of mitochondrial respiratory complex IV, in the effect of dietary restriction2012

    • Author(s)
      Shimokawa I, Chiba T, Park S, Komatsu T, Chung H, Mori R, Kusudo T, Yamashita H, Park D
    • Organizer
      2012 Spring Conference of the Korean Society for Gerontology and the 11th Korea-Japan Gerontologist Joint meeting
    • Place of Presentation
      Osong, Korea
    • Invited
    • Data Source
      KAKENHI-PROJECT-24659351
  • [Presentation] The necessity of neuropeptide Y in the effect of dietary restriction in mice2012

    • Author(s)
      Shimokawa I, Chiba T, Park S, Komatsu T, Chung H, Mori R, Kusudo T, Yamashita H, Park D
    • Organizer
      Keystone Symposia, Aging and Diseases of Aging
    • Place of Presentation
      Tokyo
    • Data Source
      KAKENHI-PROJECT-22390042
  • [Presentation] Overexpression of regulators/ senescence-related signals in adipose tissue2011

    • Author(s)
      蒲原涼太郎、下川功
    • Organizer
      The 1st Nagasaki-Pusan Joint Seminar on Aging Research
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-20591674
  • [Presentation] Cytochrome c oxidase subunit VIb modulates oxidative stress in vitro2010

    • Author(s)
      Kim Sang-Eun, Shimokawa I, 他
    • Organizer
      Asian Aging Core for Longevity Research and Education 2010 Jeju Conference
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      2010-08-24
    • Data Source
      KAKENHI-PROJECT-22390042
  • [Presentation] The mechanism underlying the effect of calorie restriction : An insight from longevity genes2009

    • Author(s)
      Shimokawa I
    • Organizer
      The 2nd Hallym-Nagasaki International Joint Meeting on Aging & Neurodegenerative Diseases. Pyeongchon, Seoul
    • Place of Presentation
      Korea
    • Year and Date
      2009-02-09
    • Data Source
      KAKENHI-PROJECT-19590227
  • [Presentation] 分子レベルからみたアンチエイジング・抗酸化サプリのこれから2008

    • Author(s)
      下川功
    • Organizer
      日本抗加齢医学会 Educational Seminar
    • Place of Presentation
      東京
    • Year and Date
      2008-09-16
    • Data Source
      KAKENHI-PROJECT-19590227
  • [Presentation] カロリー制限による老化遅延、加齢病態抑制のメカニズム. ワークショップ「老化機構解明のための病理学的アプローチ」2008

    • Author(s)
      下川功
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2008-05-15
    • Data Source
      KAKENHI-PROJECT-19590227
  • [Presentation] Caloric restriction upregulates the Akt-Glut pathway in the white adipose tissue possibly through moderate suppression of growth hormone2008

    • Author(s)
      Seongjoon Park, Komatsu T, Yamaza H, Chiba T,Higami Y,Shimokawa I
    • Organizer
      第31回日本基礎老化学会
    • Place of Presentation
      松本
    • Data Source
      KAKENHI-PROJECT-19590227
  • [Presentation] Chungnam National University Annual Symposium on Microbiology and Molecular Genetics2008

    • Author(s)
      Shimokawa I
    • Organizer
      A role for growth hormone in the anti-aging effect of calorie restriction
    • Place of Presentation
      Daejeon, Korea
    • Year and Date
      2008-02-15
    • Data Source
      KAKENHI-PROJECT-19590227
  • [Presentation] Calorie restriction modulates insulin signaling through suppression of growth hormo ne. In Symposium "Aging and anti-aging"2008

    • Author(s)
      Shimokawa I
    • Organizer
      The 9th International Congress on Cell Biology
    • Place of Presentation
      Seoul, Korea
    • Data Source
      KAKENHI-PROJECT-19590227
  • [Presentation] Calorie restriction modulates insulin signaling through suppress ion of growth hormone2008

    • Author(s)
      Shimokawa l
    • Organizer
      The 9^<th> International Congress on Cell Biology
    • Place of Presentation
      ソウル、韓国
    • Year and Date
      2008-10-07
    • Data Source
      KAKENHI-PROJECT-19590227
  • [Presentation] Longevity genes with special reference to the mechanism underlying the effect of calorie restriction2008

    • Author(s)
      Shimokawa I
    • Organizer
      The 10th International Symposium : Vascular aging : Molecular exploration and microinflammatory implications
    • Place of Presentation
      Pusan National University, Korea
    • Year and Date
      2008-12-12
    • Data Source
      KAKENHI-PROJECT-19590227
  • [Presentation] Calorie restriction increases TORC2-dependent CREB activity for induction of gluconeogenetic gene expression by down-regulation of AMPK2008

    • Author(s)
      Lucas S. Trindade, Komatsu T, Yamaza H, Chiba T,Higami Y,Shimokawa I
    • Organizer
      第31回日本基礎老化学会
    • Place of Presentation
      松本
    • Data Source
      KAKENHI-PROJECT-19590227
  • [Presentation] foxO1 is not involved in the calorie restriction - specific response to oxidative stress in mice liver2007

    • Author(s)
      Komatsu T, Fukumoto Y, Mashima H, Furuyama T, Chiba T, Yamaza H, Higami H, Shimokawa I
    • Organizer
      36th Annual Meeting of American Aging Association
    • Place of Presentation
      San Antonio, TX USA
    • Data Source
      KAKENHI-PROJECT-19590227
  • [Presentation] 教育講演「カロリー制限とアンチエイジング」2007

    • Author(s)
      下川 功
    • Organizer
      第20回日本老年泌尿器科学会
    • Place of Presentation
      長崎
    • Year and Date
      2007-05-12
    • Data Source
      KAKENHI-PROJECT-19590227
  • 1.  HIGAMI Yoshikazu (90253640)
    # of Collaborated Projects: 13 results
    # of Collaborated Products: 26 results
  • 2.  CHIBA Takuya (40336152)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 34 results
  • 3.  MORI Ryoichi (30509310)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 18 results
  • 4.  YAMAZA Haruyoshi (30336151)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 28 results
  • 5.  TSUCHIYA Tomoshi (30437884)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 6.  NAGAYASU Takeshi (80284686)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 7.  YAMASAKI Naoya (70404217)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  AKITA Sadanori (90315250)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  池田 高良 (50034624)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  小松 利光 (70380962)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 11.  OKITA Naoyuki (60453841)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  TAGAWA Tsutomu (20363492)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  MAEDA Takahiro (40284674)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  HAYASHI Kuniaki (80039536)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  SAKAMOTO Ichiro (00225806)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  MATSUOKA Yohjiro (80181709)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  HAYASHI Hiroko (40513221)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  大畑 佳久 (60779289)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 19.  朴 盛浚 (60635853)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 20.  小林 正樹 (30795612)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  田川 亮真 (70844455)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  YAMADA Kentaro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 23.  OTABE Shuichi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 24.  稲垣 忍
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 25.  古山 達雄
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 26.  中山 ひとみ
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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