OHNISHI Yasuyuki 大西保行

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ONISHI Yasuyuki 大西保行

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Researcher Number	70201382
Other IDs
Affiliation (Current)	2025: 公益財団法人実中研, 理事長付, 研究員
Affiliation (based on the past Project Information) *help	2012: 公益財団法人実験動物中央研究所, その他部局等, 研究員 2012: 実験動物中央研究所, 研究員 2011: 慶應義塾大学, 実験動物中央研究所, 研究員 2010: (財)実験動物中央研究所, バイオメディカル研究部, 室長 2007: Central Institute for Experimental Animals, バイオメディカル研究部, 室長 … More 2007: Central Institute for Experimental Animals, Oncology Laboratory, Group director 2005 – 2006: (財)実験動物中央研究所, バイオメディカル研究部, 室長 2005 – 2006: 東海大学, 実験動物中央研究所, 研究員 2004: 実験動物中央研究所, 研究員 2003 – 2004: 実験動物中央研究所, プロジェクト推進センター, 副部長 2000 – 2003: Central Institute for Experimental Animals Lab.Oncology Head, 腫瘍研究室, 室長 2002: Cent. Inst. Exp. Anim. Lab. Oncology Head, 腫瘍研究室, 室長 2002: 実験動物中央研究所, プロジェクト推進センター, 副部長(研究職) 2001: 実験動物中央研究所, 腫瘍研究室, 室長 2001: Central Inst. of Exp. Anim., Group Director (Researcher), 実験動物中央研究所, 室長(研究職) 2001: 財団法人実験動物中央研究所, 腫瘍研究室, 研究員 2000 – 2001: 実験動物中央研究所, 室長(研究職) 1999: 財団法人実験動物中央研究所, 腫瘍研究室, 室長 1998: 実験動物中央研究所, 腫瘍研究室, 室長 1998: Cent.Inst.expr.Anim. Laboratory of Oncology Researcher, 腫瘍研究室, 研究員 1995 – 1998: Head, Central Inst.Expr.Anim., 腫瘍研究室, 室長 1996: 財団法人実験動物中央研究所, 腫瘍研究室, 研究員 1995: 財団法人実験動物中央研究所, 腫瘍研究室, 室長 1995: 財団法人歛験動物中央研究所, 腫瘍研究室, 研究員 1994 – 1995: 実験動物中央研究所, 腫瘍研, 研究員 1994: 財団法人実験動物中央研究所, 腫瘍研究室, 研究員 1993: (財)実験動物中央研究所, 腫瘍研究室, 研究員 1991 – 1992: 実験動物中央研究所, 研究員 Less
Review Section/Research Field	Principal Investigator Laboratory animal science / Laboratory animal science Except Principal Investigator Laboratory animal science / Laboratory animal science / Pathological medical chemistry / Human pathology / Biomedical engineering/Biological material science
Keywords	Principal Investigator mouse / xenograft / ヌードマウス / マウス / トランスジェニック / human neoplasm / ヒト腫瘍 / トランスレーショナル研究 / bigenic / IL-6 … More / H-ras / K-ras / xenotransplantability / vascular endotherial growth factor / ribozyme / リボザイム / ゼノグラフト / ヒト / ヒト癌 / DNAフィンガープリント / insulin resistance / translational research / strain / TRS-2 / type 2 diabetes / 自然交配 / 体外受精 / 遺伝的背景 / ノックアウトマウス / 実験動物 / 糖尿病 / PPAR / 系統 / インシュリン抵抗性 / 系統育成 / IRS-2 / 2型糖尿病 / personalized chemotherapy / htranslational research / eresistance / ant-cancer drug / microarray / nude mouse / human tumor / オーダーメード医療 / 耐性 / 抗がん剤 / マイクロアレイ / urethane / cancer prevention / knockout / transgenic / メチルニトロソウレア / p53 / ビニールカーバメート / 変異 / ビニルカーバメート / 肺がん / トランスジェニツク / ウレタン / がん予防 / ノックアウト / tetracyclin / insulin / スイッチ / 発現調節 / VEGF / 発現誘導 / インスリン / テトラサイクリン / c-erb Bhuman neoplasm / epidermal growth factor receptor / ヒト型抗体 / c-erbB-2 / P.glycoprotein / オーソトピック移植 / 腫瘍 / G-CSF / アイソフォーム / SCIDマウス / P-glycoprotein / 血管内皮増殖因子 / GM-CSF / 乳酸脱水素酵素ウイルス / C-erb B / 上皮成長因子受容体 / 異種移植性 / 血管内皮成長因子 / human / monkey / type I agent / anticancer drug / pharmacokinetics / toxicokinetics / シスプラチン / サイクロフォスファミド / マイトマイシンC / 濃度時間積 / I型抗癌剤 / トキシコテネティクス / サル / I型薬剤 / 抗癌剤 / ファーマコキネティクス / トキシコキネティクス / chemosensitivity / DNA finger print / quality control / mice, nude / フィンガープリント / Xenograft / 抗癌剤スクリーニング / ras / HLA / 薬剤感受性 / 品質管理 / 異種移植 / DNA-PKcs遺伝子 / DNA修復 / DNA障害 / RAG-2 ノックアウト / トポイソメラーゼ / カタリーティックサブユニット / DNAリン酸化キナーゼ / scid遺伝子 … More Except Principal Investigator soluble guanylate cyclase / nitric oxide / heme oxygenase / HTLV-1 / HIV-1 / p53 / c-Ha-ras / RT-PCR / 担癌動物 / NOGマウス / VP-16 / CPT-11 / DNAトポイソメラーゼ / NK cell / Metastasis / Angiogenesis / Microenvironment / NOG mouse / 多発性骨髄腫 / in vivo / ADCC / ヒト癌 / マウスモデル / 間質蛋白分解酵素 / トロンボスポンジン / 遠隔転移抑制 / 悪性黒色腫 / NK細胞 / 遠隔転移 / 血管新生 / 微小環境 / cystathionine β-synthase / knockout mice / carbon monoixde / cystathionine beta synthase / conditional knock out mice / hypoxia / carbon monoxide / heme oxgenase / microcirculation / 胆汁分泌 / cystathionine β synthase / ノックアウト動物 / アミノ酸置換体 / 硫化水素 / シスタチオニン合成酵素 / シスタチオニンベータシンターゼ / 遺伝子改変動物 / 一酸化窒素 / 可溶性グアニル酸シクラーゼ / 一酸化炭素 / ヘムオキシゲナーゼ / CD34+ stem cells / Xenotransplantation / Immunodeficiency / NOD-scid. γc null mice / experimental animals / NOD-scid,γKOマウス / CD34+細胞 / 異種移植 / 免疫不全 / NOD-scid, γKOマウス / 実験動物 / transgenic mice / ras mice / Cancer / トランスジェニックマウス / rasマウス / 発癌 / Chemosensitivity / Anticancer Drug / Cancer Xenograft / RAG-2ko Mouse / SCID Mouse / Nude Mouse / Immunodeficient Mouse / Human Tumor / 薬効評価システム / 薬剤感受性 / 抗癌剤 / 移植腫瘍 / RAG-2ノックアウトマウス / SCIDマウス / ヌードマウス / 免疫不全動物 / ヒト腫瘍 / MDR1 gene / Tumor Xenograft / In vivo Chemotherapy / P-giycoprotein / Multidrug Resistance / PCR / ヌ-ドマウス / P糖蛋白 / 病理診断 / P糖蛋白質 / 腫瘍Xenogaft / in vivo抗癌剤感受性 / 多剤耐性遺伝子 / 癌遺伝子 / 食道腺癌 / 癌幹細胞 / 5-FU / シスプラチン / 胃癌 / 細胞内導入 / 担がん動物 / 胃がん / がん遺伝子 / アパタイトナノキャリア / マイクロRNA / SN-38 / 耐性 / 化学療法 / ADR Less

The microRNAsfor the diagnosis and treatment of uppergastro-intestinal malignancy - application of appatite-nanocarrier -
- Principal Investigator
  
  SUZUKI Hidekazu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Keio University
Animal Experimentation system as an infrastructure to support translational progression of diabetes research to medical practicePrincipal Investigator
- Principal Investigator
  
  YOSUYUKI Ohnishi
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Laboratory animal science
- Research Institution
  Central Institute for Experimental Animals
Development of in vivo experimental system for analyses of human cancer inductive microenvironment by using NOG mice
- Principal Investigator
  
  UEYAMA Yoshito
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Tokai University
Analysis of molecular mechanisms by which heme oxygenase-carbon monoxide pathway regulates cellular functions under physiological and pathophysiological conditions using newly developed gene targeting mice.
- Principal Investigator
  
  SUEMATSU Makoto
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Keio University
Establishment of human tumor xenotransplantation models as a pre-clinical assisting tool for translational researchPrincipal Investigator
- Principal Investigator
  
  OHNISHI Yasuyuki
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Central Institute for Experimental Animals
The studies on the practical application of NOD-sc/d, yc null mice allowing an efficient transplantation of human cells, to human disease models
- Principal Investigator
  
  ITO Mamoru
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Central Institute for Experimental Animals
Study of control mechanisms of gene expression related to colorectal cancer by intestinal flora in rasH2 mice
- Principal Investigator
  
  ITOH Kikuji
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  The University of Tokyo
Studies on in vivo evaluation system of treatment for cancer prevention and progression using cancer prone gene-engineered micePrincipal Investigator
- Principal Investigator
  
  OHNISHI Yasuyuki
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Central Institute for Experimental Animals
Knock-down mouse, a novel gene engineering mouse for use as a disease modelPrincipal Investigator
- Principal Investigator
  
  OHNISHI Yasuyuki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Laboratory animal science
- Research Institution
  Central Institute for Experimental Animals
核酸毒作用動態に基づくDNA-PKcs/scid遺伝子のDNA修復再構成機構解析Principal Investigator
- Principal Investigator
  
  大西保行
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Laboratory animal science
- Research Institution
  Central Institute for Experimental Animals
Improvement of human tumor xenograft-mouse model as a preclinical evaluation system of new drugs discovered and developed by the novel strategy against cancerPrincipal Investigator
- Principal Investigator
  
  OHNISHI Yasuyuki
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Central Institute for Experimental Animals
自然耐性ヒト癌の耐性機構の解明とCPT-11耐性遺伝子を応用した遺伝子治療の試み
- Principal Investigator
  
  安藤俊夫
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Soka University
A new approach for prediction of clinical efficacy of anticancer drugs based on toxicokinetic and pharmacokinetic analysisPrincipal Investigator
- Principal Investigator
  
  OHNISHI Yasuyuki
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Laboratory animal science
- Research Institution
  Central Institute for Experimental Animals
Reliability of immuno deficient mice as a tool for preclinical antitumor drug evaluation
- Principal Investigator
  
  YOSHIMURA Masumi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Central Institute for Experimental Animals
自然耐性ヒト癌の耐性機構の解明とCPT-11耐性遺伝子を応用した遺伝子治療の試み
- Principal Investigator
  
  安藤俊夫
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Aichi Cancer Center Research Institute
Studies on genetic and microbiologicail quality of human tumor xenografts lines as a tool for animal experimentsPrincipal Investigator
- Principal Investigator
  
  OHNISHI Yasuyuki
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Central Institute for Experimental Animals
Expression of the Multidrug Resistance Gene (MDR1) and In Vivo Intrinsic Multidrug Resistance in Human Tumor Xenografts
- Principal Investigator
  
  TAMAOKI Norikazu
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Tokai University

All 2005

All Journal Article

[Journal Article] S100A4 expression with reduced E-cadherin expression predicts distant metastasis of human malignant melanoma cell lines in NOD/SCID/γc^<null>(NOG) mouse model2005
- Author(s)
  N.Ikoma, H.Yamazaki, Y.Ohnishi, Y.Ueyama, M.Nakamaura et al.
- Journal Title
  
  Oncology Reports 14
  
  Pages: 633-637
- Data Source
  KAKENHI-PROJECT-16300137
[Journal Article] Aberrant expression of the gastric mucin MUC6 in human pulmonary adenocarcinoma xenografts2005
- Author(s)
  A.Hamamoto, H.Yamazaki, Y.Ohnishi, Y.Ueyama, M.Nakamura et al.
- Journal Title
  
  International Journal of Oncology 26
  
  Pages: 891-896
- Data Source
  KAKENHI-PROJECT-16300137

1. NAKAMURA Masato (00164335)

# of Collaborated Projects: 6 results

# of Collaborated Products: 1 results
2. HIOKI Kyoji (80208735)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. UEYAMA Yoshito (30072408)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
4. ARAI Toshiro (70184257)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. TAMAOKI Norikazu (50055860)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 安藤俊夫 (20012693)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. SUZUKI Hidekazu (70255454)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SAITO Yoshimasa (90360114)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. AKAIKE Toshihiro (30101207)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KANAI Yae (00260315)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. YAMAMOTO Naoyuki (20250011)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. KATOH Hideki (30142053)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. SUZUKI Shuzo (80113439)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. TANIOKA Yoshikuni (10072406)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. SUGIYAMA Yuichi (80090471)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. INABA Makoto (60085636)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. YOSHIMURA Masumi (40150867)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. ENDO Sachio (50203667)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. KURAMOCHI Takashi (10225253)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. MIZUSHIMA Tomoko (90311240)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. ITOH Kikuji (50100045)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. ITOH Toshio (20106644)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. NAKAYAMA Hiroyuki (40155891)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. KOBAYASHI Kimio (20205454)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. USUI Toshimi (10311234)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. OKADA Masaji (40160684)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. TOMISAWA Masashi (10321663)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. SUEMIZU Hiroshi (40332209)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. ITO Mamoru (00176364)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. NAKAHATA Tatsutoshi (20110744)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. TANAKA Yuetsu (30163588)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. KOYANAGI Yoshio (80215417)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. SUEMATSU Makoto (00206385)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. GODA Nobuhito (00245549)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. YAMAZAKI Hitoshi (20191273)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
36. HASHIMOTO Haruo (30353478)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. TOBE Kazuyuki (30251242)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. 石田良司 (50150214)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. 鬼島宏 (90204859)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. 平山和宏 (60208858)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
41. 江川毅 (10232935)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

OHNISHI Yasuyuki 大西 保行

ONISHI Yasuyuki 大西 保行

Research Projects

Research Products

Co-Researchers

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Animal Experimentation system as an infrastructure to support translational progression of diabetes research to medical practicePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of human tumor xenotransplantation models as a pre-clinical assisting tool for translational researchPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on in vivo evaluation system of treatment for cancer prevention and progression using cancer prone gene-engineered micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Knock-down mouse, a novel gene engineering mouse for use as a disease modelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

核酸毒作用動態に基づくDNA-PKcs/scid遺伝子のDNA修復再構成機構解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Improvement of human tumor xenograft-mouse model as a preclinical evaluation system of new drugs discovered and developed by the novel strategy against cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Institution

A new approach for prediction of clinical efficacy of anticancer drugs based on toxicokinetic and pharmacokinetic analysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

OHNISHI Yasuyuki 大西保行

ONISHI Yasuyuki 大西保行