Kita Akiko 喜田昭子

… Alternative Names

KITA Akiko 喜田昭子

喜多昭子キタアキコ

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Researcher Number	70273430
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External Links
Affiliation (Current)	2025: 京都大学, 複合原子力科学研究所, 助教
Affiliation (based on the past Project Information) *help	2018 – 2024: 京都大学, 複合原子力科学研究所, 助教 2007 – 2008: Kyoto University, 原子炉実験所, 助教 2004 – 2006: Kyoto University, Research Reactor Institute, Assistant Professor, 原子炉実験所, 助手 2000 – 2003: 京都大学, 大学院・理学研究科, 助手 1998: 京都大学, 大学院理学研究科, 助手 1995 – 1997: Grad.School of Science, Kyoto Univ.Res.Assoc., 大学院・理学研究科, 助手 1996: 京都大学, 大学院理学研究科, 助手
Review Section/Research Field	Principal Investigator Structural biochemistry / Biophysics / Biophysics / Structural biochemistry Except Principal Investigator Biophysics / Medium-sized Section 38:Agricultural chemistry and related fields / Medium-sized Section 37:Biomolecular chemistry and related fields / Bioorganic chemistry / Science and Engineering
Keywords	Principal Investigator X線結晶構造解析 / 結晶化 / 結晶構造 / FAD / PixD / BLUF / ラン色細菌 / 構造変化 / 短鎖青色光受容体 / Tll0078 … More / BLUFタンパク質 / 結晶構造解析 / T110078 / 青色光受容体 / DNA結合蛋白質 / DNA結合タンパク質 / 鉄硫黄クラスター / 転写因子 / 酸化物ストレス応答 / SoxRタンパク質 / 紅色酵母 / ホロ型アルデヒド還元酵素 / アポ型アルデヒド還元酵素 / NADPH依存型酵素 / X線結晶解析 / アルデヒド還元酵素 / メタピロカテカ-ゼ / X線血漿構造解析 / メタピロカテカーゼ / カテコール2,3-酸化酵素 / 二原子酸素添加酵素 / タンパク質結晶学 / アンチポ-タ / テトラサイクリン / 膜輸送タンパク質 … More Except Principal Investigator X線結晶解析 / 毒性オリゴマー / 有機化学 / アミロイドβ / アルツハイマー病 / SPring-8 / 結晶化 / 立体構造 / 抗毒性ターン特異抗体 / オリゴマー / 脳神経疾患 / 抗体 / Cryptochrome / FAD / X-ray Crystallography / DNA Repair / Photolyase / DNA修復 / 光回復酵素 / 極低温結晶凍結 / BL41XUビームライン / タンパク質結晶解析 / 次世代大型放射光 / タンパク質結晶学 / X線構造解析 / テトラサイクリン / アンチポ-タ / 細胞膜輸送 / エンジイン型クロモフォア / DNA切断 / 抗腫瘍抗生物質 / 毒性配座特異抗体 / 抗毒性ターン抗体 / 毒性立体配座 / ジスルフィド結合 / 分子内ジスルフィド結合 / ２量体 / ジスルフィド架橋 / 分子内ジスルフィド架橋 / 神経細胞毒性 / アルツハイマー / ノックインマウス / 核酸アプタマー / フラボノイド / 診断 / 脳脊髄液 / 凝集 / 毒性ターン / BLUE Domain / Crystallization / Blue-Light Receptor / X線回析実験 / Neil1 / 塩基除去修復 / DNAグリコシラーゼ / X線回折実験 / CRY / 体内時計 / BLUFドメイン / X線結晶構造解析 / 青色光受容体 / クリプトクロム / homoprotocatechuic acid / substituent effect / oxygen activation / catechol / catechol 2,3-dioxygenase / non-heme iron / reaction mechanism / oxygenase / 酸素分子 / カテコール2,3-ジオキゲナーゼ / 酵素添加酵素 / ニトロフェノール / 電荷移動錯体 / 2,3-ジヒドロキシビフェニール / 結晶構造 / ホモプロトカテク酸 / 置換基効果 / 酸素活性化 / カテコール / カテコール2,3-ジオキシゲナーゼ / 非ヘム鉄 / 酵素反応機構 / 酸素添加酵素 / Structural Biology / 3D-Structure / 立体構想 / 構造生物学 / Flavin / Three-dimensional Structure / X-ray Crystal Structure / EP390 / Luciferase / Bioluminescence / FP390 / フラビン / タンパク質立体構造 / FP_<390> / ルシフェラーゼ / 生物発光 / Xe / K吸収端 / I / Cs / ニワトリ卵白リゾチーム / 多波長異常分散法 / 高エネルギーX線 / 超分子タンパク質 / 性能評価 Less

Development to ultra-early diagnosis and prevention of AD by using a specific antibody against the toxic conformation of amyloid beta
- Principal Investigator
  
  入江一浩
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  Doshisha University
  Kyoto University
Very early diagnosis of Alzheimer's disease by the toxic oligomer specific antibody of amyloid beta
- Principal Investigator
  
  Irie Kazuhiro
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 37:Biomolecular chemistry and related fields
- Research Institution
  Kyoto University
Novel Preventive Strategy for Alzheimer's Disease Based on the Toxic Conformation Theory of Amyloid beta
- Principal Investigator
  
  Irie Kazuhiro
- Project Period (FY)
  2014 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Kyoto University
The relationship between photoreception and structure change of the short BLUF (the sensor of Blue Light Using FAD) proteinPrincipal Investigator
- Principal Investigator
  
  KITA Akiko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  Kyoto University
短鎖青色光受容体タンパク質のX線結晶構造解析Principal Investigator
- Principal Investigator
  
  喜田昭子
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Kyoto University
高エネルギーX線によるXe,Csを用いた多波長異常分散(MAD)法
- Principal Investigator
  
  三木邦夫
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biophysics
- Research Institution
  Kyoto University
細胞内酸化物ストレス応答システムの構造生物学的研究Principal Investigator
- Principal Investigator
  
  喜田昭子
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Kyoto University
Structure and Function of DNA Repair Enzyme and Their Homologous Proteins
- Principal Investigator
  
  MIKI Kunio
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biophysics
- Research Institution
  Kyoto University
Elucidation of the structural and mechanistic basis of pollutants-and signal-transmitter-degrading dioxygenases and their directed evolution
- Principal Investigator
  
  HORIIKE Kihachiro
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  SHIGA UNIVERSITY OF MEDICAL SCIENCE
生体内不斉反応を触媒するアルデヒド還元酵素の構造生物学的研究Principal Investigator
- Principal Investigator
  
  喜田昭子
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Structural biochemistry
- Research Institution
  Kyoto University
次世代大型放射光SPring-8での超分子タンパク質結晶学研究の確立
- Principal Investigator
  
  三木邦夫
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biophysics
- Research Institution
  Kyoto University
タンパク質結晶学による二原子酸素添加酵素の分子機構に関する構造化学的研究Principal Investigator
- Principal Investigator
  
  喜田昭子
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biophysics
- Research Institution
  Kyoto University
次世代大型放射光SPring-8タンパク質結晶解析ビームラインの性能評価
- Principal Investigator
  
  三木邦夫
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biophysics
- Research Institution
  Kyoto University
タンパク質の立体構造に基づく超分子形成の分子機構の解明
- Principal Investigator
  
  三木邦夫
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
テトラサイクリン/プロトンアンチポ-タの結晶化とX線構造解析
- Principal Investigator
  
  三木邦夫
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
膜輸送タンパク質テトラサイクリン/プロトンアンチトランスポータの構造化学的研究Principal Investigator
- Principal Investigator
  
  喜田昭子
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biophysics
- Research Institution
  Kyoto University
Crystallographic Study of Molecular Mechanism of DNA Repair by Photolyase
- Principal Investigator
  
  MIKI Kunio
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biophysics
- Research Institution
  KYOTO UNIVERSITY
タンパク質の立体構造に基づく超分子形成の分子機構の解明
- Principal Investigator
  
  MIKI Kunio
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
テトラサイクリン/プロトンアンチポ-タの結晶化とX線構造解析
- Principal Investigator
  
  三木邦夫
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
Studies on Molecular Mechanism of Bioluminescence
- Principal Investigator
  
  MIKI Kunio
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Biophysics
- Research Institution
  KYOTO UNIVERSITY

All 2023 2022 2021 2019 2009 2006 2005 Other

All Journal Article Presentation

[Journal Article] Structural analysis of the TxCo-1 antibody effective against the toxic conformer of amyloid β2022
- Author(s)
  Irie Kazuhiro、Irie Yumi、Matushima Yuka、Kita Akiko、Kageyama Yusuke、Tooyama Ikuo
- Journal Title
  
  Photon Factory Highlights 2021
  
  Volume: 2021 Pages: 30-31
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H00921
[Journal Article] Structural basis of the 24B3 antibody against the toxic conformer of amyloid β with a turn at positions 22 and 232022
- Author(s)
  Irie Yumi、Matsushima Yuka、Kita Akiko、Miki Kunio、Segawa Tatsuya、Maeda Masahiro、Yanagita Ryo C.、Irie Kazuhiro
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 621 Pages: 162-167
- DOI
  10.1016/j.bbrc.2022.07.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H00921
[Journal Article] Characterization of a Conformation-Restricted Amyloid β Peptide and Immunoreactivity of Its Antibody in Human AD brain2021
- Author(s)
  Kageyama Yusuke、Irie Yumi、Matsushima Yuka、Segawa Tatsuya、Bellier Jean-Pierre、Hidaka Kumi、Sugiyama Hiroshi、Kaneda Daita、Hashizume Yoshio、Akatsu Hiroyasu、Miki Kunio、Kita Akiko、Walker Douglas G.、Irie Kazuhiro、Tooyama Ikuo
- Journal Title
  
  ACS Chemical Neuroscience
  
  Volume: 12 Issue: 18 Pages: 3418-3432
- DOI
  10.1021/acschemneuro.1c00416
- NAID
  120007161279
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08853, KAKENHI-PROJECT-19H00921, KAKENHI-PROJECT-16H06277
[Journal Article] Crystal structure analysis of the antibody that is specific to the toxic conformer of amyloid beta2019
- Author(s)
  Irie Kazuhiro、Irie Yumi、Kita Akiko
- Journal Title
  
  Photon Factory Activity Report 2018
  
  Volume: 36
- Data Source
  KAKENHI-PROJECT-19H00921
[Journal Article] Fate Determination of the Flavin Photoreceptions in the Cyanobacterial Blue Light Receptor TePixD (T110078).2006
- Author(s)
  K.Okajima, A.Kita, et al.
- Journal Title
  
  J.Mol.Biol. 363
  
  Pages: 10-18
- Data Source
  KAKENHI-PROJECT-17770086
[Journal Article] 新規青色光受容体タンパク質の結晶構造2006
- Author(s)
  喜田昭子
- Journal Title
  
  日本結晶学会誌 48
  
  Pages: 343-347
- NAID
  10018331255
- Data Source
  KAKENHI-PROJECT-17770086
[Journal Article] Structure of a Cynobacterial BLUF Protein, Tll0078, Containing a Novel FAD-binding Blue Light Sensor Domain.2005
- Author(s)
  A.Kita et al.
- Journal Title
  
  J.Mol.Biol. 349
  
  Pages: 1-9
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14208081
[Journal Article] Structure of a cyanobacterial BLUF protein, Tll0078, containing a novelFAD-binding blue-liaht sensor domain2005
- Author(s)
  A.Kita
- Journal Title
  
  J.Mol.Biol 349
  
  Pages: 1-9
- Data Source
  KAKENHI-PROJECT-17770086
[Journal Article] Structure of a Cynobacteriai BLUF Protein, TII0078, Containing a Novel FAD-binding Blue Light Sensor Domain2005
- Author(s)
  A.Kita et al.
- Journal Title
  
  J. Mol. Biol. 349
  
  Pages: 1-9
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14208081
[Journal Article] Structure of a Cynobacterial BLUF Protein, Tll0078, Containing a Novel FAD-binding Blue Light Sensor Domain
- Author(s)
  A.Kita et al.
- Journal Title
  
  J.Mol.Biol. (印刷中)
- Data Source
  KAKENHI-PROJECT-14208081
[Presentation] 毒性アミロイドβの立体構造に立脚した抗体開発2023
- Author(s)
  景山裕介、入江由美、松島由佳、瀬川辰也、喜田昭子、赤津祐康、金田大太、橋詰良夫、入江一浩、遠山育夫
- Organizer
  第12回日本認知症予防学会
- Invited
- Data Source
  KAKENHI-PROJECT-23H00325
[Presentation] 抗Aβオリゴマー抗体・24B3の毒性配座認識機構の解析2022
- Author(s)
  入江由美、松島由佳、喜田昭子、三木邦夫、瀬川辰也、前田雅弘、柳田亮、入江一浩
- Organizer
  第41回日本認知症学会学術集会、第37回日本老年精神医学会（合同開催）（東京）
- Data Source
  KAKENHI-PROJECT-19H00921
[Presentation] Development of a conformation specific antibody identifying toxic conformation of amyloid β peptide2022
- Author(s)
  Kageyama Yusuke、Irie Yumi、Matsushima Yuka、Segawa Tatsuya、Kaneda Daita、Hashizume Yoshio、Akatsu Hiroyasu、Miki Kunio、Kita Akiko、Irie Kazuhiro、Tooyama Ikuo
- Organizer
  第63回日本神経病理学会総会学術研究会（京都）
- Data Source
  KAKENHI-PROJECT-19H00921
[Presentation] 青色光受容体BLUFタンパク質の構造生物学的研究2009
- Author(s)
  喜田昭子
- Organizer
  京都大学原子炉実験所第43回学術講演会
- Place of Presentation
  京都大学原子炉実験所
- Year and Date
  2009-01-22
- Data Source
  KAKENHI-PROJECT-19570154

1. MIKI Kunio (10116105)

# of Collaborated Projects: 10 results

# of Collaborated Products: 0 results
2. KITADOKORO Kengo (60283587)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. HIGUCHI Yoshiki (90183574)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. Irie Kazuhiro (00168535)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
5. 久米利明 (10303843)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 徳田隆彦 (80242692)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 村上一馬 (80571281)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 遠山育夫 (20207533)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
9. HORIIKE Kihachiro (80089870)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KIMURA Takahide (70167378)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. TANAKA Hiroyuki (10293820)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. ISHIDA Tetsuo (10176191)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. FUJIHASHI Masahiro (10397581)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 竹田一旗 (30332290)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 宮武秀行 (50291935)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 清水孝彦 (40301791)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 池川雅哉 (60381943)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 景山裕介 (80971069)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
19. 塚野千尋 (70524255)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. BELLIER Jean-Pierre

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kita Akiko 喜田 昭子

KITA Akiko 喜田 昭子

喜多 昭子 キタ アキコ

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The relationship between photoreception and structure change of the short BLUF (the sensor of Blue Light Using FAD) proteinPrincipal Investigator

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短鎖青色光受容体タンパク質のX線結晶構造解析Principal Investigator

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細胞内酸化物ストレス応答システムの構造生物学的研究Principal Investigator

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生体内不斉反応を触媒するアルデヒド還元酵素の構造生物学的研究Principal Investigator

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タンパク質結晶学による二原子酸素添加酵素の分子機構に関する構造化学的研究Principal Investigator

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Kita Akiko 喜田昭子

KITA Akiko 喜田昭子

喜多昭子キタアキコ