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SHIRAI MANABU  白井 学

… Alternative Names

SHIRAI Manabu  白井 学

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Researcher Number 70294121
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-1063-5822
Affiliation (Current) 2025: 国立研究開発法人国立循環器病研究センター, オープンイノベーションセンター, 室長
Affiliation (based on the past Project Information) *help 2019 – 2024: 国立研究開発法人国立循環器病研究センター, オープンイノベーションセンター, 室長
2018: 国立研究開発法人国立循環器病研究センター, その他, 室長
2016 – 2017: 国立研究開発法人国立循環器病研究センター, 創薬オミックス解析センター, 室長
2015 – 2016: 国立研究開発法人国立循環器病研究センター, 研究所, 室長
2015: 国立研究開発法人国立循環器病研究センター, 分子生物学部, 室長 … More
2012 – 2014: 独立行政法人国立循環器病研究センター, 研究所, 室長
2013: 独立行政法人国立循環器病研究センター, 分子生物学部, 室長
2012: 独立行政法人国立循環器病研究センター, 分子生物学部, 研究員
2012: 独立行政法人国立循環器病研究センター, 分子生物部, 室長
2010 – 2011: 独立行政法人国立循環器病研究センター, 分子生物学部, 室長
2009: National Cardiovascular Center Research Institute, バイオサイエンス部, 室員
2007: National Cardiovascular Center Research Institute, 研究所・バイオサイエンス部, 室員
2005 – 2006: National Cardiovascular Center Research Institute, Department of Bioscience, Research Staff, バイオサイエンス部, 室員
2005: 国立循環器病センター(研究所), バイオサイエンス部, 室長
2004: 国立循環器病センター研究所, バイオサイエンス部, 室員
1999: 大阪大学, 遺伝情報実験施設, 助手
1997 – 1999: Research Associate, Research Institute for Microbial Diseases, 微生物病研究所, 助手 Less
Review Section/Research Field
Principal Investigator
Basic Section 52050:Embryonic medicine and pediatrics-related / Pediatrics / Studies on the Super-Aging Society / Cardiovascular medicine / General medical chemistry / General anatomy (including Histology/Embryology)
Except Principal Investigator
Basic Section 53020:Cardiology-related / Basic Section 52050:Embryonic medicine and pediatrics-related / General anatomy (including histology/embryology) / Pathological medical chemistry … More / Basic Section 58020:Hygiene and public health-related: including laboratory approach / Medium-sized Section 52:General internal medicine and related fields / Basic Section 44020:Developmental biology-related / Pediatrics / General medical chemistry / Human genetics / General anatomy (including Histology/Embryology) Less
Keywords
Principal Investigator
エピジェネティック因子 / 心臓前駆細胞 / ポリコーム遺伝子 / 心臓発生 / 先天性心疾患 / 転写調節因子 / 心筋細胞 / 発生医学 / ポリコーム遺伝子群 / Cell-cell communication … More / エピジェネティック / エピジェネティック変動 / 心臓組織 / 老化 / 恒常性維持 / 心臓形態形成 / 心不全 / 形態形成 / 遺伝子ノックダウン法 / RNA干渉 / CATCH22症候群 / Hand1 / Nkx2.5 / ルーピング異常 / Polycomb group遺伝子群 / rae28 … More
Except Principal Investigator
急性心不全 / 川崎病 / 抗SSA抗体 / Geminin / 細胞分化 / 先天性心疾患 / 心血管発生 / ゲノムワイド関連解析 / 心不全 / トランスクリプトーム / ウイルス / 心内膜炎 / 腱索断裂 / 乳児特発性僧帽弁腱索断裂 / 僧帽弁閉鎖不全 / 幹細胞 / ES細胞 / 心筋細胞 / Nkx2-5 / Has2 / Tbx2 / BMP / ALK1 / BMPR2 / cre-loxP / 胚性幹細胞 / 心筋 / ポリコーム遺伝子群 / ポリコーム複合体 / 心臓幹細胞 / 神経堤細胞 / ポリホメオティック遺伝子 / CATCH22症候群 / rae28遺伝子 / プロテオーム / 不均一性 / 遺伝統計 / ゲノム解析 / 遺伝統計学 / 疾患感受性遺伝子 / 脳出血 / 遺伝性血管病 / 心内膜炎 ウイルス / 遺伝子発現制御 / リスク予測 / 突然死 / GWAS / 複雑形質 / 人種特異性 / マルチオミックス解析 / リスク層別化 / ポリジニックリスクスコア / 選択的スプライシング / 人種横断的解析 / ブルガダ症候群 / エピゲノム / マウス胚 / ゲノム編集 / 細胞増殖 / ニワトリ胚 / 神経分化 / モルフォゲン / 中枢神経系 / オルガノイド / 神経損傷 / マウス / 神経管 / BMPシグナル / 大脳腹側部 / Prominin-1 / コンピテンス / Phc1 / ソニック・ヘッジホッグ / 内在分子型 / 診断法 / 高精度診断法 / ANP前駆体 / 心筋細胞変性 / 心不全診断法 / 生合成機序 / proANP / β-ANP / ANP分子型測定法 / 心房性ナトリウム利尿ペプチド / 心筋内炎症 / 介在板 / 網羅的解析 / メタゲノム / SSA抗体 / 乳児 / トランスクリプトーム解析 / DNA網羅的解析 / 僧帽弁腱索 / 僧帽弁検索断裂 / RNAトランスクリプトーム解析 / メタゲノム解析 / 僧帽弁腱索断裂 / 心筋分裂 / 細胞周期 / DNA microarray / RNA interference / endocardial cell / cell differentiation / ES cell / cardiomyocyte / マイクロアレイ / 心内膜 / 心筋分化 / マイクロアレイ解析 / RNA干渉 / 心内膜細胞 / Genetic Analysis / Primary Plumonary Hypertension / 原発性高血圧症 / TGF-β / 原発性肺高血圧症 / polycomb / transgenic mice / transcriptional factor / ポリコーム / 遺伝子導入動物 / 転写因子 / neural crest / segment specification / Hox / Polycomb group / rae28 / protein interactions / polyomeotic / bmil / ファロ-の四徴 / 臓器形成不全 / ショウジョウバエ / 臓器形成制御 / ral28遺伝子 / 微小変異 / トランスサイレチン / 胚性腫瘍細胞 / ジーンターゲティング / 遺伝子標的組み込み / ポリコーム複合体1 / 維持 / 心筋維持 / 心臓発生 / 再生医学 / 組織形成 / 遺伝子発現維持機構 / Hox遺伝群 / ポリコ-ム遺伝子群 / 14-3-3 / F9細胞 Less
  • Research Projects

    (28 results)
  • Research Products

    (54 results)
  • Co-Researchers

    (48 People)
  •  Cell-cell communicationから紐解く、心臓前駆細胞を取り巻く細胞社会の解明Principal Investigator

    • Principal Investigator
      白井 学
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Mechanisms of cellular signaling implicated in cardiovascular development and disease

    • Principal Investigator
      中川 修
    • Project Period (FY)
      2024 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      National Cardiovascular Center Research Institute
  •  心臓発生期のゲノム網羅的エンハンサーアトラスと心臓内領域特異的遺伝子発現制御機構

    • Principal Investigator
      中川 修
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 52:General internal medicine and related fields
    • Research Institution
      National Cardiovascular Center Research Institute
  •  心筋細胞のheterogeneityとその特性解明に基づいた心疾患の包括的理解

    • Principal Investigator
      山口 修
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      Ehime University
  •  Investigation of virus RNA analysis using FFPE specimens to clarify the pathogenesis of acute rupture of chodae tendineae of the mitral valve in infants

    • Principal Investigator
      黒嵜 健一
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Research for Risk Stratification of cerebral hemorrhage

    • Principal Investigator
      高橋 篤
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 58020:Hygiene and public health-related: including laboratory approach
    • Research Institution
      National Cardiovascular Center Research Institute
  •  A key intercalated disc molecule determines the prognosis of dilated cardiomyopathy

    • Principal Investigator
      Shintani Yasunori
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Crosstalk between transcriptional factors and epigenetic factors in cardiac progenitor cell development.Principal Investigator

    • Principal Investigator
      Shirai Manabu
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      National Cardiovascular Center Research Institute
  •  A multi-omics study to elucidate the novel molecular basis of the complex traits and ethnicity in Brugada syndrome

    • Principal Investigator
      Makita Naomasa
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Development of a high-precision diagnostic method for heart failure utilizing abnormal biosynthesis of beta-atrial natriuretic peptide in the failing heart

    • Principal Investigator
      Minamino Naoto
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      Protein Research Foundation
  •  Positional and quantitative regulation of the central nervous cells by interaction of pattern formation, proliferation and differentiation timing

    • Principal Investigator
      Sasai Noriaki
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 44020:Developmental biology-related
    • Research Institution
      Nara Institute of Science and Technology
  •  Transcroiptome and Metagenome Analysis of Patients with Acute Rupture of Chordae Tendeneae of the Mitral Valve in Infants

    • Principal Investigator
      SHIRAISHI ISAO
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Analysis of epigenetic disruption in cardiomyocyte senescence and disease.Principal Investigator

    • Principal Investigator
      Manabu Shirai
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Studies on the Super-Aging Society
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Epigenetic regulation of cardiac progenitor cells development in lateral plate mesoderm/pharyngeal region.Principal Investigator

    • Principal Investigator
      Shirai Manabu
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Functional analysis of Polycomb group proteins in adult heartPrincipal Investigator

    • Principal Investigator
      Shirai Manabu
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cardiovascular medicine
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Detection of cell-cycling cardiac muscle cells by visualizing Geminin, and regeneration of cardiac muscle cells

    • Principal Investigator
      Takihara Yoshihiro
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      General anatomy (including histology/embryology)
    • Research Institution
      Hiroshima University
  •  Research on Pathogenesis of Acute Rupture of Chordae Tendinae of the Mitral Valve in Infants: Possible involvement of maternally derived anti-SSA antibody

    • Principal Investigator
      Shiraishi Isao
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Molecular role for Geminin in maintaining cardiac muscles

    • Principal Investigator
      TAKIHARA Yoshihiro
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      General anatomy (including histology/embryology)
    • Research Institution
      Hiroshima University
  •  Functional analysis of Polycomb-group genes in regulating mechanisms for self-reneual and differentiation of cardiac progenitor cells.Principal Investigator

    • Principal Investigator
      SHIRAI Manabu
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Detection and functional analysis of cardiac stem cells

    • Principal Investigator
      TAKIHARA Yoshihiro
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      General anatomy (including Histology/Embryology)
    • Research Institution
      Hiroshima University
  •  Functional analysis of Polycomb-group gene, Pcgf5 in cardiac morphogenesisPrincipal Investigator

    • Principal Investigator
      SHIRAI Manabu
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      National Cardiovascular Center Research Institute
  •  F0遺伝子ノックダウン法を用いた、心筋分化誘導・決定に関わる新規因子の同定と解析Principal Investigator

    • Principal Investigator
      白井 学
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General medical chemistry
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Isolation and analysis of transcription factors associated with Nkx2-5 and cardiac differentiation

    • Principal Investigator
      HIDEKA Kyoko
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Genetic analysis of Primary Pulmonary Hypertension and possible involvement of Tbx genes via BMP signaling in the pathogenesis of PPH.

    • Principal Investigator
      MORISAKI Hiroko
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Human genetics
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Gene Regulation in Cardiac Development

    • Principal Investigator
      MIWA Takeshi
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Institution
      Osaka University
  •  マウス心臓発生におけるPolycomb group遺伝子群の役割の解析Principal Investigator

    • Principal Investigator
      白井 学
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      General anatomy (including Histology/Embryology)
    • Research Institution
      Osaka University
  •  細胞分化の新しい制御機構の分子レベル及び個体レベルでの解析

    • Principal Investigator
      TAKIHARA Yoshihiro
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Osaka University
  •  GENERATION OF MOUSE MODELS FOR HUMAN GENETIC DISEASESTHROUGH GENE TARGETING

    • Principal Investigator
      SHIMADA Kazunori
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Osaka University

All 2024 2023 2022 2021 2020 2019 2017 2016 2015 2014 2013 2012 2011 2007 Other

All Journal Article Presentation Book

  • [Book] Etiology and morphogenesis of congenital heart disease2016

    • Author(s)
      Shirai, M., Takihara, Y., Morisaki, T.
    • Total Pages
      383
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-15K15018
  • [Journal Article] Combination of blockade of endothelin signalling and compensation of IGF1 expression protects the retina from degeneration2024

    • Author(s)
      Shigesada Naoya、Shikada Naoya、Shirai Manabu、Toriyama Michinori、Higashijima Fumiaki、Kimura Kazuhiro、Kondo Toru、Bessho Yasumasa、Shinozuka Takuma、Sasai Noriaki
    • Journal Title

      Cellular and Molecular Life Sciences

      Volume: 81 Issue: 1 Pages: 1-18

    • DOI

      10.1007/s00018-023-05087-x

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K06382, KAKENHI-PROJECT-20H03263
  • [Journal Article] Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome‐wide association and whole genome sequencing analyses2023

    • Author(s)
      Shiraishi Kouya、Takahashi Atsushi、、et al.
    • Journal Title

      Cancer Communications

      Volume: 44 Issue: 2 Pages: 287-293

    • DOI

      10.1002/cac2.12498

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K16166, KAKENHI-PROJECT-20K07378, KAKENHI-PROJECT-21K06900, KAKENHI-PROJECT-22K07681, KAKENHI-PROJECT-21K19444, KAKENHI-PROJECT-20K17668, KAKENHI-PROJECT-22H04923, KAKENHI-PROJECT-22H00455, KAKENHI-PROJECT-20H03525, KAKENHI-PROJECT-21H03550, KAKENHI-PROJECT-23K24602, KAKENHI-PROJECT-23K27389, KAKENHI-PROJECT-23K27506
  • [Journal Article] Acquisition of neural fate by combination of BMP blockade and chromatin modification2023

    • Author(s)
      Ong Agnes Lee Chen、Kokaji Toshiya、Kishi Arisa、Takihara Yoshihiro、Shinozuka Takuma、Shimamoto Ren、Isotani Ayako、Shirai Manabu、Sasai Noriaki
    • Journal Title

      iScience

      Volume: 26 Issue: 11 Pages: 108257-108257

    • DOI

      10.1016/j.isci.2023.108257

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21H02889
  • [Journal Article] Manipulation of signal gradient and transcription factors recapitulates multiple hypothalamic identities2023

    • Author(s)
      Maho Yamamoto, Agnes Ong Lee Chen, Takuma Shinozuka, Manabu Shirai, Noriaki Sasai.
    • Journal Title

      Stem Cells

      Volume: N/A Issue: 5 Pages: 453-467

    • DOI

      10.1093/stmcls/sxad018

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H03263
  • [Journal Article] Acquisition of neural fate by combination of BMP blockade and chromatin modification2023

    • Author(s)
      Ong Agnes Lee Chen、Kokaji Toshiya、Kishi Arisa、Takihara Yoshihiro、Shinozuka Takuma、Shimamoto Ren、Isotani Ayako、Shirai Manabu、Sasai Noriaki
    • Journal Title

      iScience

      Volume: 26 Issue: 10 Pages: 107887-107887

    • DOI

      10.1016/j.isci.2023.107887

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K16349, KAKENHI-PROJECT-20H03263
  • [Journal Article] Utility of perinatal natriuretic peptide for predicting neonatal heart failure2022

    • Author(s)
      Miyoshi Takekazu、Hosoda Hiroshi、Miyake Akira、Sakaguchi Heima、Kitano Masataka、Kurosaki Ken‐ichi、Shiraishi Isao、Nakai Michikazu、Nishimura Kunihiro、Miyazato Mikiya、Kangawa Kenji、Yoshimatsu Jun、Minamino Naoto
    • Journal Title

      Pediatrics International

      Volume: 64 Issue: 1

    • DOI

      10.1111/ped.15231

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K07833, KAKENHI-PROJECT-19K08343, KAKENHI-PROJECT-20K08414
  • [Journal Article] Sox14 is essential for initiation of neuronal differentiation in the chick spinal cord2021

    • Author(s)
      Katsuyama Taiki、Kadoya Minori、Shirai Manabu、Sasai Noriaki
    • Journal Title

      Developmental Dynamics

      Volume: 251 Issue: 2 Pages: 350-361

    • DOI

      10.1002/dvdy.392

    • NAID

      120007165093

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21H02889, KAKENHI-PROJECT-21K15105
  • [Journal Article] Transcription of the Geminin gene is regulated by a negative-feedback loop.2014

    • Author(s)
      Ohno, Y., Saeki, K., Yasunaga, S., Kurogi. T., Suzuki-Takedachi, K., Shirai, M., Mihara K., Yoshida, K., Voncken J. W, Ohtsubo, M. & Takihara Y.
    • Journal Title

      Mol. Biol. Cel

      Volume: 25(8) Issue: 8 Pages: 1374-1383

    • DOI

      10.1091/mbc.e13-09-0534

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23618008, KAKENHI-PROJECT-24591595, KAKENHI-PROJECT-24790976, KAKENHI-PUBLICLY-25118717, KAKENHI-PUBLICLY-25130708, KAKENHI-PROJECT-25670096, KAKENHI-PROJECT-26501004
  • [Journal Article] Scmh1 has E3 ubiquitin ligase activity for Geminin and histone H2A and regulates Geminin stability directly or indirectly via transcriptional repression of Hoxa9 and Hoxb42013

    • Author(s)
      Yasunaga, S., Ohtsubo, M., Ohno, Y., Tanaka-Okamoto, M., Ishizaki, H., Shirai, M., Mihara, K., Brock, W. H., Miyoshi, J., Takihara, Y.
    • Journal Title

      Mol. Cell. Biol

      Volume: 33 Pages: 644-660

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659096
  • [Journal Article] Scmh1 has E3 ubiquitin ligase activity for Geminin and histone H2A and regulates Geminin stability directly or indirectly via transcription repression of Hoxa9 and Hoxb42013

    • Author(s)
      Yasunaga, S., Ohtsubo, M., Ohno, Y., Saeki, K., Kurogi. T., Tanaka-Okamoto, M., Ishizaki, H., Shirai, M., Mihara, K., Brock, H. W., Miyoshi, J. & Takihara Y
    • Journal Title

      Mol. Cell. Biol.

      Volume: 33(4) Issue: 4 Pages: 644-660

    • DOI

      10.1128/mcb.00974-12

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23618008, KAKENHI-PROJECT-23659096, KAKENHI-PROJECT-24591595, KAKENHI-PROJECT-24790976, KAKENHI-PUBLICLY-25130708, KAKENHI-PUBLICLY-23118519, KAKENHI-PUBLICLY-23130511
  • [Journal Article] Efficient capture of cardiogenesis-associated genes expressed in ES cells.2007

    • Author(s)
      Terami H, Hidaka K, Shirai M, Narumiya H, Kuroyanagi T, Arai Y, Aburatani H, Morisaki T
    • Journal Title

      Biochem Biophys Res Commun. 355(1)

      Pages: 47-53

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590260
  • [Journal Article] Endocardiogenesis in embryoid bodies : Novel markers identified by gene expression profiling.2007

    • Author(s)
      Narumiya H, Hidaka K, Shirai M, Terami H, Aburatani H, Morisaki T
    • Journal Title

      Biochem Biophys Res Commun. 357(4)

      Pages: 896-902

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590260
  • [Journal Article] Efficient capture of cardiogenesis-associated genes expressed in ES cells.2007

    • Author(s)
      Terami H, Hidaka K, Shirai M, Narumiya H, Kuroyanagi T, Arai Y, Aburatani H, Morisaki T
    • Journal Title

      Biochem Biophys Res Commun. 355・1

      Pages: 47-53

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590260
  • [Journal Article] Endocardiogenesis in embryoid bodies : Novel markers identified by gene expression profiling2007

    • Author(s)
      Narumiya H, Hidaka K, Shirai M, Terami H, Aburatani H, MD, Morisaki T
    • Journal Title

      Biochem Biophys Res Commun 357・4

      Pages: 896-902

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590260
  • [Journal Article] Endocardiogenesis in embryoid bodies : Novel markers identified by gene expression profiling

    • Author(s)
      Narumiya H, Hidaka K, Shirai M, Terami H, Aburatani H, MD, Morisai T
    • Journal Title

      Biochem Biophys Res Commun. (in press)

    • Data Source
      KAKENHI-PROJECT-17590260
  • [Presentation] Acquisition of Neural Fate by Combination of BMP Blockade and Chromatin Modification2023

    • Author(s)
      Noriaki Sasai Toshiya Kokaji Takuma ShinozukaManabu Shirai Agnes Ong Lee Chen
    • Organizer
      第46回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H03263
  • [Presentation] 発生期の心臓内領域特異的な遺伝子発現を制御するエンハンサーの探索2023

    • Author(s)
      原田恭弘、王韵策、岩瀬晃康、白井学、荒井勇二、植山萌恵、渡邉裕介、栗原裕基、中川修、川村晃久
    • Organizer
      第46回 日本分子生物学会
    • Data Source
      KAKENHI-PROJECT-21H02889
  • [Presentation] 発生期の心臓内領域特異的な遺伝子発現を制御するエンハンサーの探索2023

    • Author(s)
      原田恭弘、王韵策、岩瀬晃康、白井学、荒井勇二、植山萌恵、渡邉裕介、栗原裕基、中川修 、川村晃久
    • Organizer
      第46回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-23K24602
  • [Presentation] BMPシグナルの抑制とクロマチン修飾の協働による神経分化制御2023

    • Author(s)
      Agnes Lee Chen Ong、小鍛冶俊也、篠塚琢磨、白井学、笹井紀明
    • Organizer
      第46回 日本分子生物学会
    • Data Source
      KAKENHI-PROJECT-21H02889
  • [Presentation] BMPシグナルの抑制とクロマチン修飾の協働による神経分化制御2023

    • Author(s)
      Agnes Lee Chen Ong、小鍛冶俊也、篠塚琢磨、白井学、笹井紀明
    • Organizer
      第46回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-23K24602
  • [Presentation] 種特異的な発生時間によって制御される神経管のサイズ2022

    • Author(s)
      笹井 紀明 白井学 篠塚 琢磨 磯谷 綾子
    • Organizer
      第45回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H03263
  • [Presentation] Species-specific developmental rate determining the size of the vertebrate neural tube2022

    • Author(s)
      Noriaki Sasai, Manabu Shirai, Takuma Shinozuka
    • Organizer
      第45回 日本分子生物学会
    • Data Source
      KAKENHI-PROJECT-21H02889
  • [Presentation] An Essential Role of Polyhomeotic Homolog 1 (Phc1) in Early Neural Development2022

    • Author(s)
      Agnes Ong Lee Chen Manabu Shirai Noriaki Sasai
    • Organizer
      ASCB/EMBO meeting 2022
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03263
  • [Presentation] 過去のFFPE切片からを用いたRNAトランスクリプトーム解析および高感度in situ hybridization法による乳児特発性僧帽弁腱索断裂の病態および病原微生物の検討2021

    • Author(s)
      白井学、白石公
    • Organizer
      第57回日本小児循環器学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K08290
  • [Presentation] 生物種に特有の神経管サイズを制御する分子メカニズムの解明2020

    • Author(s)
      勝山大暉、白井学、笹井紀明
    • Organizer
      第43回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-20H03263
  • [Presentation] Essential Roles of Polyhomeotic Homolog 1 (Phc1) in Early Retinal Development2020

    • Author(s)
      Agnes Ong Lee Chen, Manabu Shirai, Noriaki Sasai
    • Organizer
      American Society of Cell Biology, ASCB (American Society of cell biology) / EMBO meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03263
  • [Presentation] Essential Roles of Polyhomeotic Homolog 1 (Phc1) in Early Retinal Development2020

    • Author(s)
      Noriaki Sasai, Agnes Ong Lee Chen, Manabu Shirai
    • Organizer
      第43回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H03263
  • [Presentation] 種特異的な神経管サイズを制御する分子メカニズムの解析2020

    • Author(s)
      勝山大暉、白井学、吉鷹玲奈、笹井紀明
    • Organizer
      第42回 日本分子生物学会
    • Data Source
      KAKENHI-PROJECT-18H02786
  • [Presentation] Essential Roles of Polyhomeotic Homolog 1 (Phc1) in Early Retinal Development2020

    • Author(s)
      Agnes Ong Lee Chen, Manabu Shirai, Noriaki Sa
    • Organizer
      第42回 日本分子生物学会
    • Data Source
      KAKENHI-PROJECT-18H02786
  • [Presentation] Polyhomeotic homolog 1 regulates the formation of optic cup-like organoids.2019

    • Author(s)
      Agnes Ong Lee Chen, Manabu Shirai, Noriaki Sasai
    • Organizer
      第41回 日本分子生物学会
    • Data Source
      KAKENHI-PROJECT-18H02786
  • [Presentation] 成体心臓の機能維持に対するポリコーム遺伝子Pcgf5(Polycomb ring finger 5)の機能解析2017

    • Author(s)
      白井 学、錦織 充広、若林 真樹、高橋 篤、金 美花、大谷 健太郎、土持 裕胤、瀧原 義宏、森崎 隆幸、南野 直人
    • Organizer
      2017年度 生命科学系学会合同年次大会
    • Data Source
      KAKENHI-PROJECT-15K09149
  • [Presentation] マウス成体心臓におけるPolycomb repressive complex 1.5 (PRC1.5) の機能的解析2016

    • Author(s)
      白井学、金美花、土持裕胤、大谷健太郎、瀧原義宏、森崎隆幸
    • Organizer
      第39回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-15K15018
  • [Presentation] Functional analysis of Polycomb repressive complex 1.5 (PRC1.5) in adult mouse heart.2016

    • Author(s)
      Shirai, M., Kim, M., Tsuchimochi, H., Otani, K., Takihara, Y., and Morisaki, T.
    • Organizer
      第39回日本分子生物学会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2016-11-29
    • Data Source
      KAKENHI-PROJECT-15K09149
  • [Presentation] Functional analysis of Polycomb ring finger 5 (Pcgf5) in the heart of adult mice.2015

    • Author(s)
      Shirai, M., Kim, M., Otani, K., Tsuchimochi, H., Takihara, Y., and Morisaki, T.
    • Organizer
      第38回日本分子生物学会
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-15K09149
  • [Presentation] 成体心臓におけるPcgf5(Polycomb ring finger 5)遺伝子の機能的解析2015

    • Author(s)
      白井学、金美花、大谷健太郎、土持裕胤、瀧原義宏、森崎隆幸
    • Organizer
      第38回日本分子生物学会年会 第88回日本生化学会大会 合同大会
    • Place of Presentation
      神戸ポートアイランド 神戸
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-15K15018
  • [Presentation] Pcgf5 contributes to PRC1 (Polycomb repressive complex 1) in developing cardiac cells.2013

    • Author(s)
      Shirai, M., Takihara, Y., Morisaki, T.
    • Organizer
      The 7th TAKAO International Symposium on Etiology and Morphogenesis of Congenital Heart Disease
    • Place of Presentation
      東京都渋谷区代々木神園町3-1 国立オリンピック記念青少年総合センター
    • Invited
    • Data Source
      KAKENHI-PROJECT-24591595
  • [Presentation] Functional analysis of Pcgf5 (Polycomb ring finger 5) in developing heart2013

    • Author(s)
      Shirai, M.
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-25670096
  • [Presentation] Functional analysis of Pcgf5 (Polycomb ring finger 5) in the developing hearts.2013

    • Author(s)
      Shirai, M., Takihara, Y., Morisaki, T.
    • Organizer
      第36回 日本分子生物学会
    • Place of Presentation
      兵庫県神戸市中央区港島中町6 神戸国際会議場、神戸国際展示場、神戸ポートピアホテル
    • Data Source
      KAKENHI-PROJECT-24591595
  • [Presentation] Distribution of Polycomb-group proteins in the developing heart2012

    • Author(s)
      Manabu Shirai, Yoshihiro Takihara, Takayuki Morisaki
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2012-12-13
    • Data Source
      KAKENHI-PROJECT-21591405
  • [Presentation] ポリコーム遺伝子群の心臓形態形成に対する発現・機能解析2012

    • Author(s)
      白井学、瀧原義宏、森崎隆幸
    • Organizer
      第10回心臓血管発生研究会
    • Place of Presentation
      福島
    • Year and Date
      2012-10-07
    • Data Source
      KAKENHI-PROJECT-21591405
  • [Presentation] 心臓発生における、ポリコーム遺伝子群の発現及び機能解析2012

    • Author(s)
      白井 学、瀧原 義宏、森崎 隆幸
    • Organizer
      第11回心臓血管発生研究会
    • Place of Presentation
      福島県郡山市
    • Data Source
      KAKENHI-PROJECT-24591595
  • [Presentation] 心臓発生における、ポリコーム遺伝子群の発現及び機能解析2012

    • Author(s)
      白井 学、瀧原義宏、森崎隆幸
    • Organizer
      日本心臓血管発生研究会
    • Place of Presentation
      熱海
    • Data Source
      KAKENHI-PROJECT-23659096
  • [Presentation] Functional analysis of Pcgf5 (Polycomb ring finger 5)2012

    • Author(s)
      Shirai, M., Takihara, Y., and Morisaki, T.
    • Organizer
      第 35 回日本分子生物学会
    • Place of Presentation
      福岡県福岡市
    • Data Source
      KAKENHI-PROJECT-24591595
  • [Presentation] Functional analysis of Pcgf5 (Polycomb Ring Finger 5) gene during Cardiogenesis.2012

    • Author(s)
      Shirai, M., Takihara, Y., Morisaki, T
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-23659096
  • [Presentation] ポリコーム遺伝子群の心臓形態形成に対する発現・機能解析2012

    • Author(s)
      白井 学
    • Organizer
      心臓血管発生研究会
    • Place of Presentation
      郡山
    • Data Source
      KAKENHI-PROJECT-23659096
  • [Presentation] ポリコーム遺伝子群の心臓形態形成に対する発現・機能解析2011

    • Author(s)
      白井学
    • Organizer
      第10回心臓血管発生研究会
    • Place of Presentation
      磐梯熱海温泉ホテル華の湯
    • Year and Date
      2011-10-07
    • Data Source
      KAKENHI-PROJECT-21591405
  • [Presentation] ポリコーム遺伝子群の心臓形態形成に対する発現・機能解析2011

    • Author(s)
      白井 学、瀧原義宏、森崎隆幸
    • Organizer
      心臓血管発生研究会
    • Place of Presentation
      郡山
    • Data Source
      KAKENHI-PROJECT-23659096
  • [Presentation] Distribution of Polycomb-group proteins in the developing heart2011

    • Author(s)
      Shirai, M., Takihara, Y., Morisaki, T
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23659096
  • [Presentation] Distribution of Polycomb-group proteins in the developing heart2011

    • Author(s)
      白井学
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-12-13
    • Data Source
      KAKENHI-PROJECT-21591405
  • [Presentation] 心臓の領域化に関与するTbx2の機能解析2007

    • Author(s)
      白井 学
    • Organizer
      第30回 日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-13
    • Data Source
      KAKENHI-PROJECT-18790213
  • [Presentation] Functional roles of Polycomb ring finger 5 (Pcgf5) in the heart of adult mice.

    • Author(s)
      Shirai, M., Otani, K., Tsuchimochi, H., Takihara, Y., and Morisaki, T.
    • Organizer
      第37回日本分子生物学会
    • Place of Presentation
      神奈川県横浜市西区みなとみらい1-1-1 パシフィコ横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Data Source
      KAKENHI-PROJECT-24591595
  • [Presentation] Distribution of Polycomb-group proteins in the developing heart

    • Author(s)
      Shirai, M.
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23659096
  • [Presentation] Functional roles of Polycomb Ring Finger 5 (Pcgf5) in the heart of adult mice.

    • Author(s)
      Shirai, M., Otani, K., Tsuchimochi, H., Takihara, Y., Morisaki, T.
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜、パシフィコ横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Data Source
      KAKENHI-PROJECT-25670096
  • 1.  TAKIHARA Yoshihiro (60226967)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 11 results
  • 2.  MORISAKI Takayuki (30174410)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 14 results
  • 3.  若林 真樹 (70552024)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 4.  MORISAKI Hiroko (40311451)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 10 results
  • 5.  Sasai Noriaki (80391960)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 13 results
  • 6.  YASUNAGA Shin'ichiro (50336111)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 3 results
  • 7.  Shiraishi Isao (80295659)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 8.  高橋 篤 (50392014)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 9.  HONDA Masahiko (10455545)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  TOMOTSUNE Daihachiro (80283802)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  NOMURA Midori (60263315)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  OHNO Yoshinori (10548986)
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    # of Collaborated Products: 2 results
  • 13.  中川 修 (40283593)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  原田 恭弘 (70911402)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 15.  川村 晃久 (90393199)
    # of Collaborated Projects: 2 results
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  • 16.  SHIMADA Kazunori (40037354)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  MIWA Takeshi (20174229)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  HIDEKA Kyoko (00216681)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 19.  Shintani Yasunori (20712243)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  Minamino Naoto (50124839)
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  • 21.  Makita Naomasa (00312356)
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  • 22.  渡邉 琢也 (20627509)
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  • 23.  大郷 恵子 (30601827)
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  • 24.  山崎 悟 (70348796)
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  • 27.  磯谷 綾子 (20444523)
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  • 28.  近藤 亨 (30270573)
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  • 29.  別所 康全 (70261253)
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  • 32.  岡田 随象 (70727411)
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  • 33.  沖田 孝一 (80382539)
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  • 37.  橋本 大輝 (40911342)
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  • 41.  植山 萌恵 (60844280)
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