Urasaki Akihiro 浦崎明宏

… Alternative Names

SAKUMURA Yuichi 作村諭一

浦崎明宏ウラサキアキヒロ

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Researcher Number	40550083
Other IDs
Affiliation (Current)	2025: 神戸大学, 科学技術イノベーション研究科, 特命准教授 2025: 神戸大学, 先端バイオ工学研究センター, 特命准教授
Affiliation (based on the past Project Information) *help	2023: 神戸大学, 先端バイオ工学研究センター, 特命准教授 2023: 京都府立医科大学, 医学部, 研究員 2019 – 2022: 国立研究開発法人国立循環器病研究センター, 研究所, 室長 2016: 愛知県立大学, 情報科学研究科, 准教授 2014 – 2016: 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 2010: National Institute of Genetics, 研究員 2009: National Institute of Genetics, 個体遺伝研究系, 博士研究員
Review Section/Research Field	Principal Investigator Basic Section 48010:Anatomy-related / Developmental biology / Molecular biology Except Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Medium-sized Section 52:General internal medicine and related fields / Basic Section 48010:Anatomy-related / Neurophysiology / General neuroscience
Keywords	Principal Investigator ゼブラフィッシュ / 遺伝性出血性末梢血管拡張症 / ACVRL1 / 血管形成 / オスラー病 / 遺伝性出血性末梢血管拡張症（HHT） / 消化管血管形成 / ALK1シグナル / acvrl1 / マウス … More / 脈管 / 発生 / 血管 / 組織形成 / shootin1 / 遺伝子トラップ / 後主静脈 / mekk3 … More Except Principal Investigator 心血管発生 / 先天性心疾患 / 心筋細胞 / 内皮細胞 / シグナル伝達 / 遺伝子組換えマウス / 遺伝性血管病 / 先天性心血管疾患 / 遺伝子発現制御 / 血管病 / Notch/Rbpjシグナル伝達経路 / 心室筋 / 細胞系譜 / 転写 / 心筋 / エンハンサー / 転写制御 / 細胞分化 / 発生 / 胸部大血管 / 心臓 / 難治性血管病 / 形態形成 / 細胞シグナル伝達 / TGF-β / SMAD4 / endoglin / SMAD / BMPシグナル / Smad / BMP9 / ALK1 / ACVRL1 / 遺伝性出血性末梢血管拡張症 / 大脳皮質形成 / メカノバイオロジー / ゼブラフィッシュ / ノックアウトマウス / 大脳組織形成 / Shootin Less

心臓発生期のゲノム網羅的エンハンサーアトラスと心臓内領域特異的遺伝子発現制御機構
- Principal Investigator
  
  中川修
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  National Cardiovascular Center Research Institute
ALK1シグナルの臓器特異的血管形成における意義と難治性血管疾患の発症メカニズムPrincipal Investigator
- Principal Investigator
  
  浦崎明宏
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48010:Anatomy-related
- Research Institution
  Kobe University
  National Cardiovascular Center Research Institute
Downstream genes of signaling pathways implicated in human cardiovascular diseases: in vivo significance and regulatory mechanisms
- Principal Investigator
  
  中川修
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  National Cardiovascular Center Research Institute
Integrated analysis of pathgenesis of hereditary hemorrhagic telangiectasia
- Principal Investigator
  
  Iwasa Toru
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  National Cardiovascular Center Research Institute
Role of vascular interaction in embryonic developmentPrincipal Investigator
- Principal Investigator
  
  Urasaki Akihiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48010:Anatomy-related
- Research Institution
  National Cardiovascular Center Research Institute
Molecular mechanisms of cell differentiation during development of great vessels and ventricles
- Principal Investigator
  
  Watanabe Yusuke
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48010:Anatomy-related
- Research Institution
  National Cardiovascular Center Research Institute
Significance of cellular signaling pathways in cardiovascular development and disease
- Principal Investigator
  
  NAKAGWA Osamu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  National Cardiovascular Center Research Institute
Functional analysis of shootin1 during zebrafish tissue morphogenesisPrincipal Investigator
- Principal Investigator
  
  Urasaki Akihiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Developmental biology
- Research Institution
  Nara Institute of Science and Technology
Mechanical and pathological analyses of shootin-mediated brain formation
- Principal Investigator
  
  Naoyuki Inagaki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurophysiology / General neuroscience
- Research Institution
  Nara Institute of Science and Technology
モデル脊椎動物ゼブラフィッシュを用いたリンパ管ネットワーク形成機構の解析Principal Investigator
- Principal Investigator
  
  浦崎明宏
- Project Period (FY)
  2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Developmental biology
- Research Institution
  National Institute of Genetics
脈管形成におけるmekk3bの役割の解明Principal Investigator
- Principal Investigator
  
  浦崎明宏
- Project Period (FY)
  2009
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Molecular biology
- Research Institution
  National Institute of Genetics

All 2023 2022 2021 2020 2016 2015 2014 2009 Other

All Journal Article Presentation

[Journal Article] Computational and Experimental Analyses for Pathogenicity Prediction of ACVRL1 Missense Variants in Hereditary Hemorrhagic Telangiectasia2023
- Author(s)
  Iwasa Toru、Urasaki Akihiro、Kakihana Yuki、Nagata-Akaho Nami、Harada Yukihiro、Takeda Soichi、Kawamura Teruhisa、Shiraishi Isao、Kurosaki Kenichi、Morisaki Hiroko、Yamada Osamu、Nakagawa Osamu
- Journal Title
  
  Journal of Clinical Medicine
  
  Volume: 12 Issue: 15 Pages: 5002-5002
- DOI
  10.3390/jcm12155002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15361, KAKENHI-PROJECT-22K06803, KAKENHI-PROJECT-19K08535, KAKENHI-PROJECT-21H02890
[Journal Article] Tmem100-BAC-EGFP mice to selectively mark and purify embryonic endothelial cells of large caliber arteries in mid-gestational vascular formation2021
- Author(s)
  Yumi Kinugasa-Katayama, Yusuke Watanabe, Takashi Hisamitsu, Yuichiro Arima, Norika M Liu, Ayaka Tomimatsu, Yukihiro Harada, Yuji Arai, Akihiro Urasaki, Teruhisa Kawamura, Yoshihiko Saito, Osamu Nakagawa
- Journal Title
  
  genesis
  
  Volume: 59 Issue: 4
- DOI
  10.1002/dvg.23416
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07280, KAKENHI-PROJECT-18H02787, KAKENHI-PROJECT-19H03398, KAKENHI-PROJECT-21H02890
[Journal Article] ETS‐dependent enhancers for endothelial‐specific expression of serum/glucocorticoid‐regulated kinase 1 during mouse embryo development2021
- Author(s)
  Harada Yukihiro, Tanaka Toru, Arai Yuji, Isomoto Yoshie, Nakano Atsushi, Nakao Shu, Urasaki Akihiro, Watanabe Yusuke, Kawamura Teruhisa, Nakagawa Osamu
- Journal Title
  
  Genes to Cells
  
  Volume: 26 Issue: 8 Pages: 611-626
- DOI
  10.1111/gtc.12874
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07280, KAKENHI-PROJECT-19H01140, KAKENHI-PROJECT-18H02787, KAKENHI-PROJECT-21K06790, KAKENHI-PROJECT-21K20751, KAKENHI-PROJECT-19H03398, KAKENHI-PROJECT-21H02890
[Journal Article] Identification of a shootin1 isoform expressed in peripheral tissues2016
- Author(s)
  Yasuna Higashiguchi, Kazuhiro Katsuta, Takunori Minegishi, Shigenobu Yonemura, Akihiro Urasaki, Naoyuki Inagaki
- Journal Title
  
  Cell Tissue Res.
  
  Volume: 366 Issue: 1 Pages: 75-87
- DOI
  10.1007/s00441-016-2415-9
- NAID
  120005818453
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26290007, KAKENHI-PROJECT-26840081
[Journal Article] Sox7 controls arterial specification in conjunction with hey2 and efnb2 function2015
- Author(s)
  Hermkens DM, van Impel A, Urasaki A, Bussmann J, Duckers HJ, Schulte-Merker S
- Journal Title
  
  Development
  
  Volume: 142 Pages: 1695-1704
- DOI
  10.1242/dev.117275
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26840081
[Journal Article] ラージゲルプロテオミクスを基盤とした神経細胞の軸索形成とガイダンスの解析2014
- Author(s)
  馬場健太郎、浦崎明宏、稲垣直之
- Journal Title
  
  生物物理化学　電気泳動
  
  Volume: 第５８巻　第２号 Pages: 49-52
- NAID
  130004704685
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26290007
[Journal Article] Large gel proteomics-based analyses of the mechanisms for neuronal axon formation and guidance2014
- Author(s)
  馬場健太郎、浦崎明宏、稲垣直之
- Journal Title
  
  SEIBUTSU BUTSURI KAGAKU
  
  Volume: 58 Issue: 2 Pages: 49-52
- DOI
  10.2198/sbk.58.49
- NAID
  130004704685
- ISSN
  0031-9082, 1349-9785
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-26840081
[Journal Article] Analysis of genes and genome by the To12-mediated gene and enhancer trap methods2009
- Author(s)
  浦崎明宏
- Journal Title
  
  Methods Mol Biol. 546
  
  Pages: 85-102
- Data Source
  KAKENHI-PROJECT-21870041
[Journal Article] メダカトランスポゾンTo12が開く新しいゼブラフィッシュ研究2009
- Author(s)
  浦崎明宏
- Journal Title
  
  細胞工学 28
  
  Pages: 586-591
- Data Source
  KAKENHI-PROJECT-21870041
[Presentation] Physiological importance of ALK1 signaling for organotypic vascular formation2022
- Author(s)
  Akihiro URASAKI, Yuki KAKIHANA, Nami NAGATA-AKAHO, Yukihiro HARADA, Osamu NAKAGAWA
- Organizer
  第6回日本循環器学会基礎研究フォーラム
- Data Source
  KAKENHI-PROJECT-22K06803
[Presentation] Vascular connection between newly formed intestinal and pre-existing circulatory systems during embryonic development2022
- Author(s)
  Akihiro URASAKI, Osamu NAKAGAWA
- Organizer
  第30回日本血管生物医学会学術集会
- Data Source
  KAKENHI-PROJECT-21H02890
[Presentation] Vascular connection between newly formed intestinal and pre-existing circulatory systems during embryonic development2022
- Author(s)
  Akihiro URASAKI, Osamu NAKAGAWA
- Organizer
  第30回日本血管生物医学会学術集会
- Data Source
  KAKENHI-PROJECT-22K06803
[Presentation] Physiological importance of ALK1 signaling for organotypic vascular formation2022
- Author(s)
  Akihiro URASAKI, Yuki KAKIHANA, Nami NAGATA-AKAHO, Yukihiro HARADA, Osamu NAKAGAWA
- Organizer
  第6回日本循環器学会基礎研究フォーラム
- Data Source
  KAKENHI-PROJECT-21H02890
[Presentation] Physiological significance of ALK1 signaling in zebrafish organotypic vascular formation2021
- Author(s)
  Akihiro Urasaki, Nami Akaho Nagata, Yuki Kakihana, Yukihiro Harada, Osamu Nakagawa
- Organizer
  BCVR 第5回日本循環器学会基礎研究フォーラム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07280
[Presentation] Physiological significance of ALK1 signaling in zebrafish organotypic vascular formation2021
- Author(s)
  Akihiro URASAKI, Nami NAGATA-AKAHO, Yuki KAKIHANA, Yukihiro HARADA, Osamu NAKAGAWA
- Organizer
  第5回日本循環器学会基礎研究フォーラム
- Data Source
  KAKENHI-PROJECT-21H02890
[Presentation] Physiological significance of ALK1 signaling in zebrafish organotypic vascular formation2021
- Author(s)
  Akihiro URASAKI, Nami Akaho NAGATA, Yuki KAKIHANA, Yukihiro HARADA, Osamu NAKAGAWA
- Organizer
  日本循環器学会基礎研究フォーラム
- Data Source
  KAKENHI-PROJECT-18H02787
[Presentation] 臓器特異的血管形成におけるALK1シグナルの生理学的重要性2020
- Author(s)
  浦崎明宏、中川修
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07280
[Presentation] The role of singar during neuronal circuit development2016
- Author(s)
  Takuro Kono，Hitomi Nakazawa，Colleen F. Manning，James S. Trimmer，Kenji Kohno，Akihiro Urasaki，Naoyuki Inagaki
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-26290007
[Presentation] 神経回路形成におけるSingarの役割の解析2016
- Author(s)
  高野拓郎、中澤瞳、Colleen F. Manning、James S. Trimmer、河野憲二、浦崎明宏、稲垣直之
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-26840081
[Presentation] In vivo function of singar which regulates polarity of cultured hippocampal neurons2015
- Author(s)
  Takuro, Kono., Hitomi, Nakazawa., Colleen, F Manning., James, S Trimmer., Kenji, Kono., Akihiro, Urasaki., Naoyuki, Inagaki.
- Organizer
  第38回日本神経科学会大会
- Place of Presentation
  神戸国際展示場（兵庫県神戸市）
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-26290007
[Presentation] To12を用いたゼブラフィッシュ遺伝子の網羅的破壊2009
- Author(s)
  浦崎明宏
- Organizer
  日本遺伝学会第81回大会
- Place of Presentation
  松本
- Data Source
  KAKENHI-PROJECT-21870041
[Presentation] The gene trap approach reveals involvement of mekk3b in the functionsl blood vessel formation2009
- Author(s)
  浦崎明宏
- Organizer
  6th European Zebrafish Genetics and Development Meetins
- Place of Presentation
  Rome
- Data Source
  KAKENHI-PROJECT-21870041
[Presentation] ゼブラフィッシュを用いた脳形成におけるShootin1の役割の解析
- Author(s)
  浦崎明宏、渡瀬恵美子、松井貴輝、川上浩一、別所康全、稲垣直之
- Organizer
  第66回日本細胞生物学会大会
- Place of Presentation
  奈良県新公会堂(奈良県奈良市）
- Year and Date
  2014-06-11 – 2014-06-13
- Data Source
  KAKENHI-PROJECT-26290007
[Presentation] Role of shootin1 during embryonic development in zebrafish
- Author(s)
  A. Urasaki, T. Matsui, K. Kawakami, Y. Bessho, N. Inagaki
- Organizer
  The 2014 ASCB meeting
- Place of Presentation
  Philadelphia （USA）
- Year and Date
  2014-12-06 – 2014-12-10
- Data Source
  KAKENHI-PROJECT-26840081
[Presentation] 生体内における神経極性安定化因子Singarの役割の解析
- Author(s)
  高野拓郎，中澤瞳，Colleen F Manning，James S Trimmer，河野憲二，浦崎明宏，稲垣直之
- Organizer
  第37回日本神経科学学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-26290007
[Presentation] ゼブラフィッシュを用いた脳形成におけるshootin1の役割
- Author(s)
  浦崎明宏、渡瀬恵美子、松井貴輝、川上浩一、別所康全、稲垣直之
- Organizer
  第66回日本細胞生物学会大会
- Place of Presentation
  奈良県新公会堂(奈良県奈良市)
- Year and Date
  2014-06-11 – 2014-06-13
- Data Source
  KAKENHI-PROJECT-26840081
[Presentation] Role of shootin1 during embryonic development in zebrafish
- Author(s)
  A.Urasaki, T.Matsui, K.Kawakami, Y.Bessho, N.Inagaki
- Organizer
  2014　American Society for Cell Biology Annual Meeting
- Place of Presentation
  Pennsylvania Convention Center (Philadelphia,USA)
- Year and Date
  2014-12-06 – 2014-12-10
- Data Source
  KAKENHI-PROJECT-26290007

1. NAKAGWA Osamu (40283593)

# of Collaborated Projects: 7 results

# of Collaborated Products: 10 results
2. Watanabe Yusuke (20562333)

# of Collaborated Projects: 6 results

# of Collaborated Products: 2 results
3. 橋本大輝 (40911342)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. 原田恭弘 (70911402)

# of Collaborated Projects: 5 results

# of Collaborated Products: 7 results
5. LAMRI LYNDA (90883984)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
6. 垣花優希 (40910534)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
7. 劉孟佳 (50826922)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
8. Iwasa Toru (80712843)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 白石公 (80295659)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 瀬谷大貴 (30806021)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 田中亨 (50806065)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. 能丸寛子 (30885538)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. 川村晃久 (90393199)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. Naoyuki Inagaki (20223216)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
15. 黒嵜健一 (40561460)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 石川泰輔 (60708692)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 田村昌子 (30849261)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 西谷友重 (50393244)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 小柴和子 (30467005)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 白井学 (70294121)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 高橋篤 (50392014)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Urasaki Akihiro 浦崎 明宏

SAKUMURA Yuichi 作村 諭一

浦崎 明宏 ウラサキ アキヒロ

Research Projects

Research Products

Co-Researchers

心臓発生期のゲノム網羅的エンハンサーアトラスと心臓内領域特異的遺伝子発現制御機構

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ALK1シグナルの臓器特異的血管形成における意義と難治性血管疾患の発症メカニズムPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Downstream genes of signaling pathways implicated in human cardiovascular diseases: in vivo significance and regulatory mechanisms

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Integrated analysis of pathgenesis of hereditary hemorrhagic telangiectasia

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of vascular interaction in embryonic developmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanisms of cell differentiation during development of great vessels and ventricles

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Significance of cellular signaling pathways in cardiovascular development and disease

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional analysis of shootin1 during zebrafish tissue morphogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanical and pathological analyses of shootin-mediated brain formation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

モデル脊椎動物ゼブラフィッシュを用いたリンパ管ネットワーク形成機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

脈管形成におけるmekk3bの役割の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Computational and Experimental Analyses for Pathogenicity Prediction of ACVRL1 Missense Variants in Hereditary Hemorrhagic Telangiectasia2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tmem100-BAC-EGFP mice to selectively mark and purify embryonic endothelial cells of large caliber arteries in mid-gestational vascular formation2021

Author(s)

Journal Title

Urasaki Akihiro 浦崎明宏

SAKUMURA Yuichi 作村諭一

浦崎明宏ウラサキアキヒロ