Fujio Keishi 藤尾圭志

… Alternative Names

FUJIO Keishi 藤尾圭志

Less

Researcher Number	70401114
Other IDs
Affiliation (Current)	2025: 東京大学, 医学部附属病院, 教授
Affiliation (based on the past Project Information) *help	2017 – 2024: 東京大学, 医学部附属病院, 教授 2016: 東京大学, 医学部附属病院, 講師 2013 – 2014: 東京大学, 医学部附属病院, 講師 2012: 東京大学, 医学部附属病院, 特任講師(病院) 2007 – 2011: The University of Tokyo, 医学部附属病院, 助教 2007: The University of Tokyo, Hospital, Assistant Professor 2006: 東京大学, 医学部附属病院, 助手
Review Section/Research Field	Principal Investigator 膠原病・アレルギー・感染症内科学 / Basic Section 54020:Connective tissue disease and allergy-related / Collagenous pathology/Allergology Except Principal Investigator Broad Section I / Basic Section 09050:Tertiary education-related / Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 54020:Connective tissue disease and allergy-related / Immunology / 膠原病・アレルギー・感染症内科学
Keywords	Principal Investigator 制御性T細胞 / サイトカイン / 疾患感受性多型 / 遺伝素因 / ノックアウトマウス / 関節リウマチ / TGF-beta / 自己免疫疾患 / 炎症性腸疾患 / レトロウイルスベクター … More / 免疫制御 / 獲得免疫 / リンパ球 / 免疫寛容 / オートファジー / B細胞 / 全身性エリテマトーデス / マウスモデル / ChIPシークエンス / エピゲノム制御 / 炎症メディエーター / 転写因子複合体 / 炎症性サイトカイン / スーパーエンハンサー / トランスクリプトーム / 滑膜線維芽細胞 / エピゲノム修飾 / Egr2 / TGF-beta3 / IL-10 / TGF-β3 / LAG3 / TGF-β / 遺伝子発現解析 / 次世代シークエンス / T細胞レセプター / 自己抗原 / 抗体産生 / STAT / JAKキナーゼ / 自己反応性B細胞 / 免疫抑制療法 / 移植拒絶反応 … More Except Principal Investigator 関節リウマチ / 運動器恒常性維持 / シングルセル解析 / 変形性関節症 / 自己免疫疾患 / ネットワーク形成 / 研究セキュリティ / スタートアップ・エコシステム / 実務者ネットワーク / リスク管理 / 利益相反 / 研究インテグリティ / エコシステム / スタートアップ / プロテオミクス / シングルセル / AI / 小児 / 全身性エリテマトーデス / 関節炎 / 免疫細胞 / 運動器 / 骨免疫 / 自己免疫性間質性肺炎 / Egr2 / 肺線維症 / TGF-β / CD4陽性T細胞 / 膠原病 / TGF-β1 / T細胞 / 自己免疫性疾患 / 間質性肺炎 / 運動器学 / 整形外科学 / 統合運動器学 / ヒトゲノム解析 / 骨粗鬆症 / 運動器科学 / 炎症・がん / DAMP / 免疫原性核酸 / がん / HMGB1 / 自然免疫受容体 / 炎症 / 自然免疫 / 恒常性維持 / 免疫シグナル伝達 / internal medicine / genetics / Immunology / エルゴチオネイン / サイトカイン / SLC22A4 / 有機カチオントランスポーター / 疾患関連遺伝子 / 遺伝学 / 内科 / ゲノム / 免疫学 Less

Establishment of an integrated locomotive science including spatiotemporal dynamics of bone-articular cells
- Principal Investigator
  
  田中栄
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section I
- Research Institution
  The University of Tokyo
Elucidation of immunogenetic features of childhood-onset SLE by referencing adult peripheral blood single-cell data using AI
- Principal Investigator
  
  宮前多佳子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Tokyo Women's Medical University
Research on creating a governance structure to manage research integrity risks in university-originated startup ecosystems
- Principal Investigator
  
  明谷早映子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 09050:Tertiary education-related
- Research Institution
  The University of Tokyo
Mechanisms of pathogenic B cell differentiation associated with genetic risk for systemic lupus erythematosus.Principal Investigator
- Principal Investigator
  
  Fujio Keishi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  The University of Tokyo
Establishment of an integrated locomotive science including dynamics of bone-articular cells and regulation by immune system
- Principal Investigator
  
  Tanaka Sakae
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section I
- Research Institution
  The University of Tokyo
Elucidation of pathogenesis of autoimmune-mediated interstitial lung disease based on epigenomic analysis
- Principal Investigator
  
  OKAMURA Tomohisa
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  The University of Tokyo
Analysis of epigenetic structure responsible for inflammatory mediator production from rheumatoid arthritis synovial fibroblastPrincipal Investigator
- Principal Investigator
  
  FUJIO KEISHI
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  The University of Tokyo
Inhibitory cytokine-producing Treg-mediated control of autoimmunityPrincipal Investigator
- Principal Investigator
  
  Fujio Keishi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  The University of Tokyo
Elucidation of the host's homeostatic responses by the regulation of immune system and its application to the prevention and treatment of immunological disorders
- Principal Investigator
  
  Taniguchi Tadatsugu
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo
Construction of an analysis system for antigen-specific immune response in human autoimmunityPrincipal Investigator
- Principal Investigator
  
  FUJIO KEISHI
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  The University of Tokyo
Analysis of Egr2-expressing regulatory T cells in mice and humanPrincipal Investigator
- Principal Investigator
  
  FUJIO KEISHI
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  The University of Tokyo
Comparison analysis of two different human regulatory T cell populationsPrincipal Investigator
- Principal Investigator
  
  FUJIO Keishi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  The University of Tokyo
Analysis of a novel regulatory T cell subset associated with a T cell anergy inducing genePrincipal Investigator
- Principal Investigator
  
  FUJIO Keishi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  The University of Tokyo
Analyses of a cation transporters during immune and inflammatory responses
- Principal Investigator
  
  YAMAMOTO Kazuhiko
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  The University of Tokyo

[Book] 医学のあゆみサイトカインのすべて 271巻5号　「IL-10ファミリーによる免疫制御機構」2019
- Author(s)
  河野正憲、岡村僚久、藤尾圭志
- Total Pages
  5
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-19H03697
[Journal Article] Age-associated CD4+ T cells with B cell-promoting functions are regulated by ZEB2 in autoimmunity.2024
- Author(s)
  Goto M, Takahashi H, Yoshida R, Itamiya T, Nakano M, Nagafuchi Y, Harada H, Shimizu T, Maeda M, Kubota A, Toda T, Hatano H, Sugimori Y, Kawahata K, Yamamoto K, Shoda H, Ishigaki K, Ota M, Okamura T, Fujio K.
- Journal Title
  
  Sci Immunol.
  
  Volume: 9 Issue: 93 Pages: 1-16
- DOI
  10.1126/sciimmunol.adk1643
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07885, KAKENHI-PROJECT-21H02960, KAKENHI-PROJECT-23K24369, KAKENHI-PROJECT-23K24373
[Journal Article] Machine learning-driven immunophenotypic stratification of mixed connective tissue disease, corroborating the clinical heterogeneity2024
- Author(s)
  Izuka Shinji、Komai Toshihiko、Itamiya Takahiro、Ota Mineto、Nagafuchi Yasuo、Shoda Hirofumi、Matsuki Kosuke、Yamamoto Kazuhiko、Okamura Tomohisa、Fujio Keishi
- Journal Title
  
  Rheumatology
  
  Volume: - Issue: 3 Pages: 1409-1416
- DOI
  10.1093/rheumatology/keae158
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16355, KAKENHI-PROJECT-22KJ0995, KAKENHI-PROJECT-21H02960
[Journal Article] B cell receptor repertoire abnormalities in autoimmune disease2024
- Author(s)
  Yuuki Hayato、Itamiya Takahiro、Nagafuchi Yasuo、Ota Mineto、Fujio Keishi
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 15
- DOI
  10.3389/fimmu.2024.1326823
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02960
[Journal Article] Multimodal repertoire analysis unveils B cell biology in immune-mediated diseases2023
- Author(s)
  Ota Mineto、Nakano Masahiro、Nagafuchi Yasuo、Kobayashi Satomi、Hatano Hiroaki、Yoshida Ryochi、Akutsu Yuko、Itamiya Takahiro、Ban Nobuhiro、Tsuchida Yumi、Shoda Hirofumi、Yamamoto Kazuhiko、Ishigaki Kazuyoshi、Okamura Tomohisa、Fujio Keishi
- Journal Title
  
  Annals of the Rheumatic Diseases
  
  Volume: 82 Issue: 11 Pages: 1455-1463
- DOI
  10.1136/ard-2023-224421
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02960, KAKENHI-PROJECT-23K24369
[Journal Article] Functional evaluation of rare OASL variants by analysis of SLE patient-derived iPSCs2023
- Author(s)
  Natsumoto Bunki、Shoda Hirofumi、Nagafuchi Yasuo、Ota Mineto、Okumura Takashi、Horie Yumi、Okamura Tomohisa、Yamamoto Kazuhiko、Tsuji Motonori、Otsu Makoto、Taniguchi Hideki、Fujio Keishi
- Journal Title
  
  Journal of Autoimmunity
  
  Volume: 139 Pages: 103085-103085
- DOI
  10.1016/j.jaut.2023.103085
- Data Source
  KAKENHI-PROJECT-21H02960
[Journal Article] Dysregulation of the gene signature of effector regulatory T cells in the early phase of systemic sclerosis2022
- Author(s)
  Kobayashi Satomi、Nagafuchi Yasuo、Okubo Mai、Sugimori Yusuke、Hatano Hiroaki、Yamada Saeko、Nakano Masahiro、Yoshida Ryochi、Takeshima Yusuke、Ota Mineto、Tsuchida Yumi、Iwasaki Yukiko、Setoguchi Keigo、Kubo Kanae、Okamura Tomohisa、Yamamoto Kazuhiko、Shoda Hirofumi、Fujio Keishi
- Journal Title
  
  Rheumatology
  
  Volume: Online ahead of print Issue: 10 Pages: 4163-4174
- DOI
  10.1093/rheumatology/keac031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03697, KAKENHI-PROJECT-21K16283, KAKENHI-PROJECT-20K08800
[Journal Article] Distinct transcriptome architectures underlying lupus establishment and exacerbation2022
- Author(s)
  Nakano Masahiro　et al.
- Journal Title
  
  Cell
  
  Volume: 185 Issue: 18 Pages: 3375-3389.e21
- DOI
  10.1016/j.cell.2022.07.021
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05285, KAKENHI-PROJECT-21H02960, KAKENHI-PROJECT-20K08800, KAKENHI-PROJECT-21K20647, KAKENHI-PROJECT-23K24373
[Journal Article] Immune cell multiomics analysis reveals contribution of oxidative phosphorylation to B-cell functions and organ damage of lupus2022
- Author(s)
  Takeshima Yusuke、Iwasaki Yukiko、Nakano Masahiro、Narushima Yuta、Ota Mineto、Nagafuchi Yasuo、Sumitomo Shuji、Okamura Tomohisa、Elkon Keith、Ishigaki Kazuyoshi、Suzuki Akari、Kochi Yuta、Yamamoto Kazuhiko、Fujio Keishi
- Journal Title
  
  Annals of the Rheumatic Diseases
  
  Volume: - Issue: 6 Pages: 845-853
- DOI
  10.1136/annrheumdis-2021-221464
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02849, KAKENHI-PROJECT-19H03697, KAKENHI-PROJECT-21H02960, KAKENHI-PROJECT-18H05285, KAKENHI-PROJECT-21K19501
[Journal Article] AFF3, a susceptibility factor for autoimmune diseases, is a molecular facilitator of immunoglobulin class switch recombination2022
- Author(s)
  Tsukumo Shin-ichi、Subramani Poorani Ganesh、Seija Noe、Tabata Mizuho、Maekawa Yoichi、Mori Yuya、Ishifune Chieko、Itoh Yasushi、Ota Mineto、Fujio Keishi、Di Noia Javier M.、Yasutomo Koji
- Journal Title
  
  Science Advances
  
  Volume: 8 Issue: 34 Pages: 1-15
- DOI
  10.1126/sciadv.abq0008
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02960, KAKENHI-PROJECT-18K15191, KAKENHI-PROJECT-20H03478
[Journal Article] Autotaxin is a potential link between genetic risk factors and immunological disturbances of plasmacytoid dendritic cells in systematic lupus erythematosus2022
- Author(s)
  Tsuchida Yumi、Shoda Hirofumi、Nakano Masahiro、Ota Mineto、Okamura Tomohisa、Yamamoto Kazuhiko、Kurano Makoto、Yatomi Yutaka、Fujio Keishi、Sawada Tetsuji
- Journal Title
  
  Lupus
  
  Volume: 31 Issue: 13 Pages: 1578-1585
- DOI
  10.1177/09612033221128494
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02960, KAKENHI-PROJECT-20K08800
[Journal Article] Combined plasma metabolomic and transcriptomic analysis identify histidine as a biomarker and potential contributor in SLE pathogenesis2022
- Author(s)
  Iwasaki Yukiko、Takeshima Yusuke、Nakano Masahiro、Okubo Mai、Ota Mineto、Suzuki Akari、Kochi Yuta、Okamura Tomohisa、Endo Takaho、Miki Ichiro、Sakurada Kazuhiro、Yamamoto Kazuhiko、Fujio Keishi
- Journal Title
  
  Rheumatology
  
  Volume: 62 Issue: 2 Pages: 905-913
- DOI
  10.1093/rheumatology/keac338
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02960, KAKENHI-PROJECT-20K08799
[Journal Article] Multiomics landscape of synovial fibroblasts in rheumatoid arthritis2021
- Author(s)
  Tsuchiya Haruka、Ota Mineto、Fujio Keishi
- Journal Title
  
  Inflammation and Regeneration
  
  Volume: 41 Issue: 1 Pages: 7-7
- DOI
  10.1186/s41232-021-00157-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16275, KAKENHI-PROJECT-18H02846
[Journal Article] Identifying the most influential gene expression profile in distinguishing ANCA-associated vasculitis from healthy controls.2021
- Author(s)
  Yanaoka H, Nagafuchi Y, Hanata N, Takeshima Y, Ota M, Suwa Y, Shirai H, Sugimori Y, Okubo M, Kobayashi S, Hatano H, Yamada S, Tsuchida Y, Iwasaki Y, Sumitomo S, Shoda H, Okada M, Okamura T, Yamamoto K, Fujio K.
- Journal Title
  
  J Autoimmun.
  
  Volume: 119 Pages: 102617-102617
- DOI
  10.1016/j.jaut.2021.102617
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K17439, KAKENHI-PROJECT-19H03697, KAKENHI-PROJECT-20K08800
[Journal Article] Integrated bulk and single-cell RNA-sequencing identified disease-relevant monocytes and a gene network module underlying systemic sclerosis.2021
- Author(s)
  Kobayashi S, Nagafuchi Y, Okubo M, Sugimori Y, Shirai H, Hatano H, Junko M, Yanaoka H, Takeshima Y, Ota M, Iwasaki Y, Sumitomo S, Okamura T, Yamamoto K, Shoda H, Fujio K.
- Journal Title
  
  J Autoimmun
  
  Volume: 116 Pages: 102547-102547
- DOI
  10.1016/j.jaut.2020.102547
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03697, KAKENHI-PROJECT-20K08800
[Journal Article] Dynamic landscape of immune cell-specific gene regulation in immune-mediated diseases2021
- Author(s)
  Ota M, Nagafuchi Y, Hatano H, Ishigaki K, Terao C, Takeshima Y, Yanaoka H, Kobayashi S, Okubo M, Shirai H, Sugimori Y, Maeda J, Nakano M, Yamada S, Yoshida R, Tsuchiya H, Tsuchida Y, Iwasaki Y, Sumitomo S, Shoda H, Kochi Y, Okada Y, Yamamoto K, Okamura T, Fujio K, et al.
- Journal Title
  
  Cell
  
  Volume: 184 Issue: 11 Pages: 1-16
- DOI
  10.1016/j.cell.2021.03.056
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08771, KAKENHI-PROJECT-18H02849, KAKENHI-PROJECT-21H02960, KAKENHI-PROJECT-21K16283, KAKENHI-PROJECT-20K08800
[Journal Article] Parsing multiomics landscape of activated synovial fibroblasts highlights drug targets linked to genetic risk of rheumatoid arthritis2020
- Author(s)
  Tsuchiya Haruka、Ota Mineto、Sumitomo Shuji、Ishigaki Kazuyoshi、Suzuki Akari、Sakata Toyonori、Tsuchida Yumi、Inui Hiroshi、Hirose Jun、Kochi Yuta、Kadono Yuho、Shirahige Katsuhiko、Tanaka Sakae、Yamamoto Kazuhiko、Fujio Keishi
- Journal Title
  
  Annals of the Rheumatic Diseases
  
  Volume: 80 Issue: 4 Pages: 440-450
- DOI
  10.1136/annrheumdis-2020-218189
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K16275, KAKENHI-PROJECT-18H05285, KAKENHI-PROJECT-18H02846
[Journal Article] Immune Profiling and Precision Medicine in Systemic Lupus Erythematosus2019
- Author(s)
  Nagafuchi Yasuo、Shoda Hirofumi、Fujio Keishi
- Journal Title
  
  Cells
  
  Volume: 8 Issue: 2 Pages: 140-140
- DOI
  10.3390/cells8020140
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-17K09971
[Journal Article] Metabolism as a key regulator in the pathogenesis of systemic lupus erythematosus2019
- Author(s)
  Takeshima Yusuke、Iwasaki Yukiko、Fujio Keishi、Yamamoto Kazuhiko
- Journal Title
  
  Seminars in Arthritis and Rheumatism
  
  Volume: 48 Issue: 6 Pages: 1142-1145
- DOI
  10.1016/j.semarthrit.2019.04.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H05787
[Journal Article] CD4+CD25+LAG3+ T Cells With a Feature of Th17 Cells Associated With Systemic Lupus Erythematosus Disease Activity2019
- Author(s)
  Kato Rika、Sumitomo Shuji、Tsuchida Yumi、Tsuchiya Haruka、Nakachi Shinichiro、Sakurai Keiichi、Hanata Norio、Nagafuchi Yasuo、Kubo Kanae、Tateishi Shoko、Kanda Hiroko、Okamura Tomohisa、Yamamoto Kazuhiko、Fujio Keishi
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 10 Pages: 1619-1619
- DOI
  10.3389/fimmu.2019.01619
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-19H03697
[Journal Article] Identification of U11snRNA as an endogenous agonist of TLR7-mediated immune pathogenesis.2019
- Author(s)
  Negishi H, Endo N, Nakajima Y, Nishiyama T, Tabunoki Y, Nishio J, Koshiba R, Matsuda A, Matsuki K, Okamura T, Negishi-Koga T, Ichinohe T, Takemura S, Ishiwata H, Iemura SI, Natsume T, Abe T, Kiyonari H, Doi T, Hangai S, Yanai H, Fujio K, Yamamoto K, Taniguchi T.
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 116 Issue: 47 Pages: 23653-23661
- DOI
  10.1073/pnas.1915326116
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07166, KAKENHI-PROJECT-18K07167, KAKENHI-PROJECT-18K15179, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-18H05285, KAKENHI-PROJECT-19H03697, KAKENHI-PROJECT-17H04050
[Journal Article] Early Growth Response Gene 2-Expressing CD4+LAG3+ Regulatory T Cells: The Therapeutic Potential for Treating Autoimmune Diseases2018
- Author(s)
  Okamura Tomohisa、Yamamoto Kazuhiko、Fujio Keishi
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 9 Pages: 1-9
- DOI
  10.3389/fimmu.2018.00340
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09918, KAKENHI-PROJECT-16K15510
[Journal Article] Reduction of CD83 Expression on B Cells and the Genetic Basis for Rheumatoid Arthritis: Comment on the Article by Thalayasingam et al2018
- Author(s)
  Tsuchida Yumi、Sumitomo Shuji、Ota Mineto、Tsuchiya Haruka、Nagafuchi Yasuo、Shoda Hirofumi、Fujio Keishi、Ishigaki Kazuyoshi、Yamaguchi Kensuke、Suzuki Akari、Kochi Yuta、Yamamoto Kazuhiko
- Journal Title
  
  Arthritis & Rheumatology
  
  Volume: 70 Issue: 10 Pages: 1695-1696
- DOI
  10.1002/art.40652
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09972, KAKENHI-PROJECT-18K16140, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-18H05285
[Journal Article] Overview of LAG-3-Expressing, IL-10-Producing Regulatory T Cells2017
- Author(s)
  Fujio Keishi、Yamamoto Kazuhiko、Okamura Tomohisa
- Journal Title
  
  Curr Top Microbiol Immunol
  
  Volume: 410 Pages: 29-45
- DOI
  10.1007/82_2017_59
- ISBN
  9783319689289, 9783319689296
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09918, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-16K15510
[Journal Article] Transforming Growth Factor-β3 Inhibits Antibody Production by Human B Cells.2017
- Author(s)
  Tsuchida Y, Sumitomo S, Ishigaki K, Suzuki A, Kochi Y, Okamura T, Yamamoto K, Fujio K.
- Journal Title
  
  PLoS One
  
  Volume: 12 Issue: 1 Pages: 1-16
- DOI
  10.1371/journal.pone.0169646
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19566, KAKENHI-PROJECT-16K15510, KAKENHI-PROJECT-15H05787
[Journal Article] Identification of tonsillar CD4±CD25=LAG3± T cells as naturally occurring IL-10-producing regulatory T cells in human lymphoid tissue.2017
- Author(s)
  Sumitomo S, Nakachi S, Okamura T, Tsuchida Y, Kato R, Shoda H, Furukawa A, Kitahara N, Kondo K, Yamasoba T, Yamamoto K, Fujio K.
- Journal Title
  
  Journal of autoimmunity.
  
  Volume: 76 Pages: 75-84
- DOI
  10.1016/j.jaut.2016.09.005
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-15K19566, KAKENHI-PROJECT-16K15510
[Journal Article] Interleukin-10-producing LAG3+ regulatory T cells are associated with disease activity and abatacept treatment in rheumatoid arthritis2017
- Author(s)
  Nakachi Shinichiro、Sumitomo Shuji、Tsuchida Yumi、Tsuchiya Haruka、Kono Masanori、Kato Rika、Sakurai Keiichi、Hanata Norio、Nagafuchi Yasuo、Tateishi Shoko、Kanda Hiroko、Okamura Tomohisa、Yamamoto Kazuhiko、Fujio Keishi
- Journal Title
  
  Arthritis Research & Therapy
  
  Volume: 19 Issue: 1 Pages: 1-11
- DOI
  10.1186/s13075-017-1309-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09918, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-16K15510
[Journal Article] Polygenic burdens on cell-specific pathways underlie the risk of rheumatoid arthritis2017
- Author(s)
  Ishigaki Kazuyoshi、Kochi Yuta、Suzuki Akari、Tsuchida Yumi、Tsuchiya Haruka、Sumitomo Shuji、Yamaguchi Kensuke、Nagafuchi Yasuo、Nakachi Shinichiro、Kato Rika、Sakurai Keiichi、Shoda Hirofumi、Ikari Katsunori、Taniguchi Atsuo、Yamanaka Hisashi、Miya Fuyuki、Tsunoda Tatsuhiko、et al.、Yamamoto Kazuhiko
- Journal Title
  
  Nature Genetics
  
  Volume: 49 Issue: 7 Pages: 1120-1125
- DOI
  10.1038/ng.3885
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07211, KAKENHI-PROJECT-17K09972, KAKENHI-PLANNED-15H05911, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-15H04965, KAKENHI-PROJECT-15H05670
[Journal Article] Increased serum concentrations of IL-1 beta, IL-21 and Th17 cells in overweight patients with rheumatoid arthritis.2017
- Author(s)
  Shoda, H., Nagafuchi, Y., Tsuchida, Y., Sakurai, K., Sumitomo, S., Fujio, K., and Yamamoto, K.
- Journal Title
  
  Arthritis Res Ther.
  
  Volume: 19 Issue: 1 Pages: 111-111
- DOI
  10.1186/s13075-017-1308-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05787
[Journal Article] The metabolic regulation in immune cells and pathogenesis of systemic lupus erythematosus ∼toward new therapeutic applications∼2017
- Author(s)
  竹島雄介、岩崎由希子、岡村僚久、藤尾圭志、山本一彦
- Journal Title
  
  Japanese Journal of Clinical Immunology
  
  Volume: 40 Issue: 1 Pages: 12-20
- DOI
  10.2177/jsci.40.12
- NAID
  130005665586
- ISSN
  0911-4300, 1349-7413
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-16K09918, KAKENHI-PROJECT-16K15510
[Journal Article] Therapeutic potential of regulatory cytokines that target B cells.2016
- Author(s)
  Fujio Keishi, Okamura Tomohisa, Sumitomo Shuji, Yamamoto Kazuhiko
- Journal Title
  
  Internal Immunology
  
  Volume: 28 Issue: 4 Pages: 189-195
- DOI
  10.1093/intimm/dxv069
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19566, KAKENHI-PROJECT-23229007, KAKENHI-PROJECT-25461493, KAKENHI-PROJECT-16K15510
[Journal Article] The effects of TGF-βs on immune responses2016
- Author(s)
  Fujio K, Komai T, Inoue M, Morita K, Okamura T, Yamamoto K.
- Journal Title
  
  Japanese Journal of Clinical Immunology
  
  Volume: 39 Issue: 1 Pages: 51-58
- DOI
  10.2177/jsci.39.51
- NAID
  130005151098
- ISSN
  0911-4300, 1349-7413
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09918, KAKENHI-PROJECT-16K15510
[Journal Article] Egr2 and Egr3 in regulatory T cells cooperatively control systemic autoimmunity through Ltbp3-mediated TGF-β3 production.2016
- Author(s)
  Morita K, Okamura T, Inoue M, Komai T, Teruya S, Iwasaki Y, Sumitomo S, Shoda H, Yamamoto K, Fujio K.
- Journal Title
  
  Proc. Natl. Acad. Sci. U S A.
  
  Volume: 113 Issue: 50 Pages: 8131-8140
- DOI
  10.1073/pnas.1611286114
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-15K19566, KAKENHI-PROJECT-16K09918
[Journal Article] Emerging roles of Egr2 and Egr3 in the control of systemic autoimmunity.2016
- Author(s)
  Morita K, Okamura T, Sumitomo S, Iwasaki Y, Fujio K, Yamamoto K.
- Journal Title
  
  Rheumatology (Oxford)
  
  Volume: 55(suppl 2) Issue: suppl 2 Pages: 76-81
- DOI
  10.1093/rheumatology/kew342
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19566, KAKENHI-PROJECT-16K09918, KAKENHI-PROJECT-16K15510
[Journal Article] Interleukin-27 in T cell immunity.2015
- Author(s)
  Iwasaki Y, Fujio K, Okamura T, Yamamoto K
- Journal Title
  
  Int J Mol Sci
  
  Volume: 16 Issue: 2 Pages: 2851-63
- DOI
  10.3390/ijms16022851
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23229007, KAKENHI-PROJECT-24390252, KAKENHI-PROJECT-25461493, KAKENHI-PROJECT-25860803
[Journal Article] TGF-β3-expressing CD4+CD25(-)LAG3+ regulatory T cells control humoral immune responses2015
- Author(s)
  Okamura T, Sumitomo S, Morita K, Iwasaki Y, Inoue M, Nakachi S, Komai T, Shoda H, Miyazaki J, Fujio K, Yamamoto K.
- Journal Title
  
  Nature Communications
  
  Volume: 6 Issue: 1 Pages: 1-14
- DOI
  10.1038/ncomms7329
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-13J04186, KAKENHI-PROJECT-23229007, KAKENHI-PROJECT-24390252, KAKENHI-PROJECT-25461493, KAKENHI-PROJECT-25860803, KAKENHI-PROJECT-25860804, KAKENHI-PROJECT-15K19566, KAKENHI-PROJECT-15H05787
[Journal Article] Regulatory T cells in systemic lupus erythematosus2015
- Author(s)
  Okamura T, Morita K, Fujio K, Yamamoto K
- Journal Title
  
  Japanese Journal of Clinical Immunology
  
  Volume: 38 Issue: 1 Pages: 69-77
- DOI
  10.2177/jsci.38.69
- NAID
  130004875954
- ISSN
  0911-4300, 1349-7413
- Language
  Japanese
- Open Access
- Data Source
  KAKENHI-PROJECT-24390252, KAKENHI-PROJECT-25461493
[Journal Article] Egr-2 transcription factor is required for Blimp-1 mediated IL-10 production in IL-27 stimulated CD4(+) T cells2013
- Author(s)
  Iwasaki, Y.
- Journal Title
  
  Eur J Immunol
  
  Volume: undefined Issue: 4 Pages: 1063-73
- DOI
  10.1002/eji.201242942
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590435, KAKENHI-PROJECT-23229007, KAKENHI-PROJECT-23590343, KAKENHI-PROJECT-23659492, KAKENHI-PROJECT-23791106, KAKENHI-PLANNED-24118002, KAKENHI-PROJECT-24390246, KAKENHI-PROJECT-24390252, KAKENHI-PROJECT-24790990, KAKENHI-PROJECT-25460594, KAKENHI-PROJECT-25461493, KAKENHI-PROJECT-25670459, KAKENHI-PROJECT-25860803
[Journal Article] Transcription factor early growth response 3 is associated with the TGF-β1 expression and the regulatory activity of CD4-positive T cells in vivo.2013
- Author(s)
  Sumitomo S, Fujio K, Okamura T, Morita K, Ishigaki K, Suzukawa K, Kanaya K, Kondo K, Yamasoba T, Furukawa A, Kitahara N, Shoda H, Shibuya M, Okamoto A, Yamamoto K.
- Journal Title
  
  J Immunol
  
  Volume: 191 Issue: 5 Pages: 2351-9
- DOI
  10.4049/jimmunol.1202106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23229007, KAKENHI-PROJECT-24390252, KAKENHI-PROJECT-24790990, KAKENHI-PROJECT-25461470, KAKENHI-PROJECT-25461493, KAKENHI-PROJECT-25670459, KAKENHI-PROJECT-25860804
[Journal Article] Regulatory cell subsets in the control of autoantibody production related to systemic autoimmunity.2013
- Author(s)
  Fujio K, Okamura T, Sumitomo S, Yamamoto K.
- Journal Title
  
  Ann Rheum Dis
  
  Volume: 72 Pages: 1-8
- DOI
  10.1136/annrheumdis-2012-202341
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23229007, KAKENHI-PROJECT-23791106, KAKENHI-PROJECT-24390252, KAKENHI-PROJECT-25461493, KAKENHI-PROJECT-25670459
[Journal Article] Egr2 and Egr3 are the unique regulators for systemic autoimmunity.2013
- Author(s)
  Sumitomo S, Fujio K, Okamura T, Yamamoto K.
- Journal Title
  
  JAKSTAT
  
  Volume: 2 Issue: 2 Pages: e23952-e23952
- DOI
  10.4161/jkst.23952
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23229007, KAKENHI-PROJECT-25461493, KAKENHI-PROJECT-25670459, KAKENHI-PROJECT-25860804
[Journal Article] Egr2 and Egr3 are the unique regulators for systemic autoimmunity.2013
- Author(s)
  Sumitomo S, Fujio K, Okamura T, Yamamoto K.
- Journal Title
  
  JAKSTAT.
  
  Volume: 2 Issue: 4 Pages: 1060-1060
- DOI
  10.1002/art.38330
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390252
[Journal Article] Roles of LAG3 and EGR2 in regulatory T cells.2012
- Author(s)
  Tomohisa Okamura
- Journal Title
  
  Ann Rheum Dis
  
  Volume: 71 Pages: 96-100
- DOI
  10.1136/annrheumdis-2011-200588
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791106, KAKENHI-PROJECT-24390252
[Journal Article] Roles of LAG3 and EGR2 in regulatory T cells2012
- Author(s)
  Okamura T, Fujio K, Sumitomo S, Yamamoto K.
- Journal Title
  
  Ann Rheum Dis
  
  Volume: 71
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591277
[Journal Article] Regulatory T cell-mediated control of autoantibody-induced inflammation2012
- Author(s)
  Fujio K, Okamura T, Sumitomo S, Yamamoto K.
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 3 Pages: 28-28
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591277
[Journal Article] Kidney-infiltrating T cell clones promote nephritis in lupus-prone mice2012
- Author(s)
  Okamoto A, Fujio K, Tsuno NH, Takahashi K, Yamamoto K
- Journal Title
  
  Kidney Int.
  
  Volume: 8 Issue: 9 Pages: 969-79
- DOI
  10.1038/ki.2012.242
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791105, KAKENHI-PROJECT-24390252
[Journal Article] Detection of autoantibodies to citrullinated BiP in rheumatoid arthritis patients and pro-inflammatory role of citrullinated BiP in collagen-induced arthritis2011
- Author(s)
  Shoda H, Fujio K, Shibuya M, Okamura T, Sumitomo S, Okamoto A, Sawada T, et al.
- Journal Title
  
  Arthritis Res Ther
  
  Volume: 13 Issue: 6 Pages: 1-12
- DOI
  10.1186/ar3520
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591277, KAKENHI-PROJECT-22591086, KAKENHI-PROJECT-22790926, KAKENHI-PROJECT-23791106
[Journal Article] Regulatory T cell-associated cytokines in systemic lupus erythematosus2011
- Author(s)
  Okamoto A, Fujio K, Okamura T, Yamamoto K.
- Journal Title
  
  J Biomed Biotechnol
  
  Volume: 2011 Pages: 463412-463412
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591277
[Journal Article] Regulatory T-cell-associated cytokines in systemic lupus erythematosus2011
- Author(s)
  Okamoto A, Fujio K, Okamura T, Yamamoto K
- Journal Title
  
  J Biomed Biotechnol
  
  Volume: 2011 Issue: 1 Pages: 463412-463412
- DOI
  10.1155/2011/463412
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591277, KAKENHI-PROJECT-23791106
[Journal Article] Regulatory polymorphisms in EGR2 are associated with susceptibility to systemic lupus erythematosus2010
- Author(s)
  Myouzen K, Kochi Y, Shimane K, Fujio K, Okamura T, Okada Y, Suzuki A, Atsumi T, Ito S, Takada K, Mimori A, Ikegawa S, Yamada R, Nakamura Y, Yamamoto K.
- Journal Title
  
  Hum Mol Genet
  
  Volume: 19 Pages: 2313-2313
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591277
[Journal Article] The Family of IL-10-secreting CD4+ T cells.2010
- Author(s)
  Fujio K, Okamura T, Yamamoto K.
- Journal Title
  
  Adv lmmunol
  
  Volume: 105 Pages: 99-130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591277
[Journal Article] The future of lupus therapy modulating autoantigen recognition2010
- Author(s)
  Okamoto A, Fujio K, Yamamoto K.
- Journal Title
  
  Lupus
  
  Volume: 19 Pages: 1474-1474
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591277
[Journal Article] Regulatory polymorphisms in EGR2 are associated with susceptibility to systemic lupus erythematosus.2010
- Author(s)
  Myouzen K, Kochi Y, Shimane K, Fujio K, Okamura T, Okada Y, Suzuki A, Atsumi T, Ito S, Takada K, Mimori A, Ikegawa S, Yamada R, Nakamura Y, Yamamoto K
- Journal Title
  
  Human Molecular Genetics (E-Pvb)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591277
[Journal Article] The future of lupus therapy modulating autoantigen recognition.2010
- Author(s)
  Okamoto A, Fujio K, Yamamoto K.
- Journal Title
  
  Lupus.
  
  Volume: 19 Pages: 1474-1481
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591277
[Journal Article] Regulatory polymorphisms in EGR2 are associated with susceptibility to systemic lupus erythematosus.2010
- Author(s)
  Myouzen K, Kochi Y, Shimane K, Fujio K, Okamura T, Okada Y, Suzuki A, Atsumi T, Ito S, Takada K, Mimori A, Ikegawa S, Yamada R, Nakamura Y, Yamamoto K
- Journal Title
  
  Hum Mol Genet
  
  Volume: 19 Pages: 2313-2320
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591277
[Journal Article] The family of IL-10 secreting CD4+T cells2010
- Author(s)
  Fujio K, Okamura T, Yamamoto K.
- Journal Title
  
  Adv Immunol
  
  Volume: 105 Pages: 99-99
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591277
[Journal Article] CD4+CD25-LAG3+ regulatory T cells controlled by the trans cription factor Egr-2.2009
- Author(s)
  Okamura T, Fujio K, Shibuya M, Sumitomo S, Shoda H, Sakaguchi S, Yamamoto K
- Journal Title
  
  Proceedings of the National Academy of Sciences of the United States of America 106
  
  Pages: 13974-13979
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591277
[Journal Article] CD4+CD25-LAG3+regulatory T cells controlled by the transcription factor Egr-22009
- Author(s)
  Okamura T, Fujio K, Shibuya M, Sumitomo S, Shoda H, Sakaguchi S, Yamamoto K.
- Journal Title
  
  Proc Natl Acad Sci USA.
  
  Volume: 106 Pages: 13974-13974
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591277
[Journal Article] Hepatocyte growth factor significantly suppresses collagen-induced arthritis in mice.2007
- Author(s)
  Okunishi K, Dohi M, Fujio K, Nakagome K, Yamamoto K., 他7名
- Journal Title
  
  J. Immunol. 179
  
  Pages: 5504-5513
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390287
[Journal Article] Interleukin-17B and interleukin-17C are associated with TNF-alpha production and contribute to the exacerbation of inflammatory arthritis2007
- Author(s)
  Yamaguchi Y, Fujio K, Shoda H, Okamoto A, Tsuno NH, Takahashi K, Yamamoto K.
- Journal Title
  
  J Immunol. 179
  
  Pages: 128-136
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390287
[Journal Article] Interleukin-17B and interleukin-17C are associated with TNF-alpha production and contribute to the exacerbation of inflammatory arthritis2007
- Author(s)
  Yamaguchi Y, Fujio K, Shoda H, Okamoto A, Yamamoto K., 他2名
- Journal Title
  
  J Immunol 179
  
  Pages: 7128-7136
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390287
[Journal Article] Hepatocyte growth factor significantly suppresses collagen-induced arthritis in mice2007
- Author(s)
  Okunjshi K, Dohi M, Fujio K, Nakagome K, Yamamoto K., 他7名
- Journal Title
  
  J Immunol 179
  
  Pages: 5504-5513
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390287
[Journal Article] Interleukin-17B and interleukin-17C are associated with TNF-alpha production and contribute to the exacerbation of inflammatory arthritis.2007
- Author(s)
  Yamaguchi Y, Fujio K, Shoda H, Okamoto A, Yamamoto K., 他2名
- Journal Title
  
  J. Immunol. 179
  
  Pages: 7128-7136
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390287
[Journal Article] Gene therapy of arthritis with TCR isolated from the inflamed paw.2006
- Author(s)
  Fujio K.
- Journal Title
  
  J Immunol. 177
  
  Pages: 8140-8147
- Data Source
  KAKENHI-PROJECT-18390287
[Patent] Ｂ細胞活性化の抑制剤及び自己免疫疾患の治療剤2014
- Inventor(s)
  藤尾圭志、岡村僚久、山本一彦、森田薫、駒井俊彦
- Industrial Property Rights Holder
  藤尾圭志、岡村僚久、山本一彦、森田薫、駒井俊彦
- Industrial Property Rights Type
  特許
- Filing Date
  2014-11-28
- Data Source
  KAKENHI-PROJECT-24390252
[Patent] 新規T細胞2008
- Inventor(s)
  藤尾圭志, 岡村僚久, 山本一彦
- Industrial Property Rights Holder
  国立大学法人, 東京大学
- Filing Date
  2008-04-10
- Overseas
- Data Source
  KAKENHI-PROJECT-19790682
[Presentation] The skewing of the B cell receptor repertoire in unswitched memory B cells correlates with the disease activity of systemic lupus erythematosus2023
- Author(s)
  Keishi Fujio
- Organizer
  The 52nd Annual Meeting of The Japanese Society for Immunology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02960
[Presentation] IgG4関連疾患におけるトランスクリプトーム解析とBCRレパトア解析2021
- Author(s)
  西脇　彩, 駒井　俊彦, 岡村　僚久, 吉田　良知, 波多野　裕明, 大久保　麻衣, 小林　聖未, 杉森　祐介, 中野　正博, 竹島　雄介, 太田　峰人, 土屋　遥香, 永渕　泰雄, 岩崎由希子, 住友秀次, 庄田　宏文, 山本　一彦, 藤尾　圭志
- Organizer
  第6回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-19H03697
[Presentation] CASTOR1の液性免疫における役割の同定2021
- Author(s)
  楠田　岳, 駒井　俊彦, 岡村　僚久, 藤尾　圭志
- Organizer
  第49回日本臨床免疫学会総会
- Data Source
  KAKENHI-PROJECT-19H03697
[Presentation] 全身性エリテマトーデスの免疫細胞種網羅的遺伝子発現データに基づく患者層別化解析2021
- Author(s)
  中野正博、岩崎由希子、竹島雄介、太田峰人、永渕泰雄、岡村僚久、藤尾圭志
- Organizer
  第42回日本炎症・再生医学会
- Data Source
  KAKENHI-PROJECT-19H03697
[Presentation] Comprehensive transcriptome analysis of systemic lupus erythematosus reveals immune cell type-specific disease relevant signatures for patient stratification2021
- Author(s)
  Masahiro Nakano, Yukiko Iwasaki, Yusuke Takeshima, Mineto Ota1, Hiroaki Hatano, Kazuyoshi Ishigaki, Yasuo Nagafuchi, Kazuhiko Yamamoto, Tomohisa Okamura, Keishi Fujio
- Organizer
  日本リウマチ学会国際育成セミナー2021 （JCR International School 2021）
- Data Source
  KAKENHI-PROJECT-19H03697
[Presentation] Analysis of class-switching to IgG4 in memory B cell subsets of IgG4-Related Disease2021
- Author(s)
  Aya Nishiwaki, Toshihiko Komai1 Yasuo Nagafuchi, Mineto Ota1, Ryochi Yoshida, Hiroaki Hatano, Haruka Tsuchiya, Saeko Yamada, Masahiro Nakano, Mai Okubo, Satomi Kobayashi, Yusuke Sugimori, Yusuke Takeshima, Yukiko Iwasaki, Shuji Sumitomo, Hirofumi Shoda, Kazuhiko Yamamoto, Tomohisa Okamura, and Keishi Fujio
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03697
[Presentation] IgG4関連疾患における末梢血免疫担当細胞のサブセットの検討2020
- Author(s)
  西脇　彩, 駒井　俊彦, 岡村　僚久, 吉田　良知, 波多野　裕明, 太田　峰人,　永渕　泰雄,　土屋　遥香,　山田紗依子, 中野　正博, 大久保　麻衣, 小林　聖未, 杉森　祐介, 竹島　雄介, 岩崎由希子, 住友秀次, 庄田　宏文, 山本　一彦, 藤尾　圭志
- Organizer
  第48回日本臨床免疫学会総会
- Data Source
  KAKENHI-PROJECT-19H03697
[Presentation] Protective roles of TGF-β3 in interstitial pneumonia with autoimmune features2020
- Author(s)
  Toshihiko Komai, Tomohisa Okamura, Ryochi Yoshida, Kazuhiko Yamamoto, Keishi Fujio
- Organizer
  第64回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19H03697
[Presentation] Immunophenotypic analysis of peripheral blood mononuclear cells in IgG4-Related Disease2020
- Author(s)
  Aya Nishiwaki, Toshihiko Komai, Tomohisa Okamura, Ryochi Yoshida, Hiroaki Hatano, Mineto Ota, Yasuo Nagafuchi, Haruka Tsuchiya, Saeko Yamada, Masahiro Nakano, Mai Okubo1, Satomi Kobayashi1, Yusuke Sugimori, Yusuke Takeshima, Yukiko Iwasaki, Shuji Sumitomo, Hirofumi Shoda, Kazuhiko Yamamoto, Keishi Fujio
- Organizer
  22th Asia-Pacific League of Associations for Rheumatology Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03697
[Presentation] 関節リウマチ患者由来滑膜線維芽細胞の統合的機能ゲノム解析2019
- Author(s)
  土屋遙香、太田峰人、住友秀次、藤尾圭志
- Organizer
  第63回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18H02846
[Presentation] Jazf1遺伝子はLAG3+ TregからのIL-10産生を負に制御する2019
- Author(s)
  河野正憲, 岡村僚久, 駒井俊彦, 井上眞璃子, 岩崎由希子, 住友秀次, 庄田宏文, 山本一彦, 藤尾圭志
- Organizer
  第47回日本臨床免疫学会
- Data Source
  KAKENHI-PROJECT-19H03697
[Presentation] Inhibitory cytokine synergy of IL-10 and TGF-β3 contributes to humoral immune tolerance mediated by metabolic reprogramming2019
- Author(s)
  Toshihiko Komai, Tomohisa Okamura, Mariko Inoue, Morita Kaoru, Yukiko Iwasaki, Shuji Sumitomo, Hirofumi Shoda, Kazuhiko Yamamoto, and Keishi Fujio
- Organizer
  第63回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19H03697
[Presentation] Synovial fibroblast eQTL and differential expressed genes2019
- Author(s)
  Keishi Fujio, Haruka Tsuchiya, Mineto Ota, Shuji Sumitomo
- Organizer
  11th International Forum on Rheumatoid Arthritis
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02846
[Presentation] 抑制性サイトカイン協調によるB細胞の免疫代謝リプログラミング2019
- Author(s)
  駒井俊彦, 岡村　僚久, 井上眞璃子, 岩崎由希子, 住友秀次, 庄田宏文, 山本一彦, 藤尾圭志
- Organizer
  第68回アレルギー学会
- Data Source
  KAKENHI-PROJECT-19H03697
[Presentation] Functional genomics reveals cell metabolism alteration of B cells in systemic lupus erythematosus2019
- Author(s)
  Keishi Fujio
- Organizer
  The 48th Annual Meeting of The Japanese Society for Immunology
- Invited
- Data Source
  KAKENHI-PROJECT-15H05787
[Presentation] Autoimmunity and B cells2019
- Author(s)
  Keishi Fujio
- Organizer
  The 48th Annual Meeting of The Japanese Society for Immunology
- Invited
- Data Source
  KAKENHI-PROJECT-15H05787
[Presentation] The role of Jazf1 in the production of IL-10 in Tr1 cells2019
- Author(s)
  Masanori Kono, Tomohisa Okamura1, Mariko Inoue, Toshihiko Komai, Yukiko Iwasaki, Yusuke Takeshima, Shuji Sumitomo, Hirofumi Shoda, Kazuhiko Yamamoto, and Keishi Fujio
- Organizer
  第63回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19H03697
[Presentation] Jazf1遺伝子はTr1細胞におけるIL-10産生を制御する2019
- Author(s)
  河野正憲, 岡村僚久, 駒井俊彦, 井上眞璃子, 岩崎由希子, 住友秀次, 庄田宏文, 山本一彦, 藤尾圭志
- Organizer
  第5回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-19H03697
[Presentation] Functional Genomics analysis of synovial fibroblast from rheumatoid arthritis2018
- Author(s)
  KEISHI FUJIO
- Organizer
  日本免疫学会シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02846
[Presentation] A landscape of autoimmune diseases from multisubset transcriptome analysis2017
- Author(s)
  Keishi Fujio
- Organizer
  4th Symposium on Max Planck-The University of Tokyo Center for Integrative
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15510
[Presentation] CD4陽性T細胞における転写因子Klf1を介したPD-L1発現誘導機構2017
- Author(s)
  照屋周造、岡村僚久、竹島雄介、駒井俊彦、井上真璃子、岩崎由希子、山本一彦、藤尾圭志
- Organizer
  第45回日本臨床免疫学会総会
- Data Source
  KAKENHI-PROJECT-16K15510
[Presentation] B細胞を抑制するCD4陽性CD25陰性LAG3陽性制御性T細胞2016
- Author(s)
  藤尾圭志、岡村僚久、駒井俊彦、井上眞璃子、森田薫、住友秀次、山本一彦
- Organizer
  第60回日本リウマチ学会総会・学術集会
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Year and Date
  2016-04-21
- Invited
- Data Source
  KAKENHI-PROJECT-16K15510
[Presentation] TGF-β3およびIL-10による協調性液性免疫制御機構の解明2016
- Author(s)
  井上眞璃子、岡村僚久、駒井俊彦、森田薫、照屋周造、岩崎由希子、住友秀次、山本一彦、藤尾圭志
- Organizer
  第60回日本リウマチ学会総会・学術集会
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-16K15510
[Presentation] The B cell control by EGR-2 expressing CD4+CD25-LAG3+ regulatory T cells2013
- Author(s)
  Keishi Fujio
- Organizer
  Autoimmunity Congress Asia
- Place of Presentation
  Hong Kong Academy of Science
- Invited
- Data Source
  KAKENHI-PROJECT-24390252
[Presentation] The role of CD4+CD25-LAG3+ regulatory T cells in autoimmune diseses2013
- Author(s)
  Keishi Fujio
- Organizer
  Annual Meeting of Japanease Society for Immunology, 2013
- Place of Presentation
  Makuhari Messe
- Data Source
  KAKENHI-PROJECT-24390252
[Presentation] 全身性エリテマトーデスと免疫制御細胞2013
- Author(s)
  藤尾圭志
- Organizer
  第57回日本リウマチ学会総会　シンポジウム
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-24390252
[Presentation] Unbiased TCR repertoire anlaysis in rheumatoid arthritis patients by combination of single-cell and next generation sequencing2013
- Author(s)
  Ishigaki Kazuyoshi, Shoda Hirofumi, Kochi Yuta, Fujio Keishi, Yamamoto K
- Organizer
  Annual Meeting of the Japanese Society for Immunology 2013
- Place of Presentation
  MAKUHARI MESSE
- Data Source
  KAKENHI-PROJECT-25670459
[Presentation] CD4+CD25-LAG3+regulatory T cells and autoimmunity2012
- Author(s)
  Keishi Fujio
- Organizer
  8^<th> International Congress on Autoimmunity
- Place of Presentation
  グラナダ、スペイン
- Year and Date
  2012-05-10
- Data Source
  KAKENHI-PROJECT-21591277
[Presentation] 制御性T細胞と自己免疫2012
- Author(s)
  藤尾圭志
- Organizer
  第56回日本リウマチ学会総会
- Place of Presentation
  高輪、東京
- Year and Date
  2012-04-27
- Data Source
  KAKENHI-PROJECT-24390252
[Presentation] 制御性T細胞と自己免疫2012
- Author(s)
  藤尾圭志
- Organizer
  日本リウマチ学会、第56回日本リウマチ学会学術総会シンポジウム
- Place of Presentation
  グランドプリンスホテル新高輪、東京、日本
- Year and Date
  2012-04-27
- Data Source
  KAKENHI-PROJECT-21591277
[Presentation] CD4+CD25-LAG3+ regulatory T cells and autoimmunity2012
- Author(s)
  KEISHI FUJIO (invited)
- Organizer
  8^<th> International Congress on Autoimmunity Satellite Symposium: Recent Progress in Autoimmune Research in Japan
- Place of Presentation
  Granada, Spain
- Year and Date
  2012-05-10
- Data Source
  KAKENHI-PROJECT-24390252
[Presentation] CD4陽性CD25陰性LAG3陽性制御性T細胞と自己免疫疾患2011
- Author(s)
  藤尾圭志
- Organizer
  第39回日本臨床免疫学会総会
- Place of Presentation
  東京、日本
- Year and Date
  2011-09-17
- Data Source
  KAKENHI-PROJECT-21591277
[Presentation] CD4+CD25-LAG3+regulatory T cells and autoimmune disease2011
- Author(s)
  藤尾圭志
- Organizer
  第40回日本免疫学会学術総会
- Place of Presentation
  幕張メッセ、千葉、日本
- Year and Date
  2011-11-29
- Data Source
  KAKENHI-PROJECT-21591277
[Presentation] CD4+CD25+LAG3+regulatory T cells and autoimmune disease2011
- Author(s)
  KEISHI FUJIO
- Organizer
  第40回日本免疫学会学術総会シンポジウム
- Place of Presentation
  幕張メッセ(招待講演)
- Year and Date
  2011-11-29
- Data Source
  KAKENHI-PROJECT-21591277
[Presentation] CD4+CD25-LAG3+regulatory T cells and autoimmunity2011
- Author(s)
  Keishi Fujio
- Organizer
  Autoimmunity Congress Asia 2011
- Place of Presentation
  シンガポール、シンガポール
- Year and Date
  2011-11-18
- Data Source
  KAKENHI-PROJECT-21591277
[Presentation] Immunological intervention strategies aimed at regulatory T cells2010
- Author(s)
  Keishi Fujio
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  Kobe, Japan
- Year and Date
  2010-08-23
- Data Source
  KAKENHI-PROJECT-21591277
[Presentation] The similarity between human tonsil CD4+CD25-LAG3+ T cells and mouse CD4+CD25-LAG3+ regulatory T cells2009
- Author(s)
  Sumitomo S, Fujio K, Okamura T, Shoda H, Yamamoto K
- Organizer
  第39回日本免疫学会総会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2009-12-03
- Data Source
  KAKENHI-PROJECT-21591277
[Presentation] IL-10 producing CD4+CD25-LAG3+ regulatory T cells naturally present in the immune system2008
- Author(s)
  Yamamoto Kazuhiko, Okamura Tomohisa, Shibuya Mihoko, Sumitomo Shuji, Shoda Hirofumi, Sakaguchi Shimon, Fujio Keishi
- Organizer
  第38回日本免疫学会総会・学術総会シンポジウム
- Place of Presentation
  京都
- Year and Date
  2008-12-01
- Data Source
  KAKENHI-PROJECT-19790682
[Presentation] 関節リウマチの病態に関与するCD4陽性T細胞クローンの候補の同定
- Author(s)
  石垣和慶、庄田宏文、高地雄太、藤尾圭志、安井哲郎、門野夕峰ほか
- Organizer
  第58回日本リウマチ学会総会
- Place of Presentation
  新高輪プリンスホテル　東京
- Year and Date
  2014-04-24 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-25670459
[Presentation] TGF-beta3産生によるCD4陽性CD25陰性LAG3陽性制御性T細胞のB細胞機能抑制
- Author(s)
  藤尾圭志
- Organizer
  第79回日本インターフェロンサイトカイン学会
- Place of Presentation
  北海道大学
- Year and Date
  2014-06-19 – 2014-06-20
- Invited
- Data Source
  KAKENHI-PROJECT-24390252
[Presentation] TGF-beta3-expressing CD4+CD25-LAG3+ regulatory T cells control humoral immune responses.
- Author(s)
  Keishi Fujio.
- Organizer
  第43回日本免疫学会学術総会　国際シンポジウム
- Place of Presentation
  京都国際会議場
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-24390252
[Presentation] 関節リウマチの病態に関与するCD4陽性T細胞クローンの同定
- Author(s)
  石垣和慶、庄田宏文、高地雄太、安井哲郎、門野夕峰、田中栄、藤尾圭志ほか
- Organizer
  第42回日本臨床免疫学会総会
- Place of Presentation
  京王プラザホテル　東京
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25670459
[Presentation] CD4+CD25-LAG3+ regulatory T cells and systemic autoimmunity.
- Author(s)
  Keishi Fujio, Tomohisa Okamura, Kaoru Morita, Mariko Inoue, Yukiko Iwasaki, Shuji Sumitomo, Shinichiro Nakachi, Kazuhiko, Yamamoto.
- Organizer
  第58回日本リウマチ学会（東京）国際リウマチシンポジウム
- Place of Presentation
  新高輪プリンスホテル
- Year and Date
  2014-04-24 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-24390252

1. YAMAMOTO Kazuhiko (80191394)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
2. KOMAI TOSHIHIKO (50803938)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
3. Tanaka Sakae (50282661)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. OKAMURA Tomohisa (10528996)

# of Collaborated Projects: 2 results

# of Collaborated Products: 28 results
5. 齋藤琢 (30456107)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 小俣康徳 (40570734)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. SAWADA Tetsuji (50235470)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KAWAHATA Kimito (70334406)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. INOUE MARIKO (60816601)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. Taniguchi Tadatsugu (50133616)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 岩倉洋一郎 (10089120)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 西尾純子 (40598679)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. 柳井秀元 (70431765)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 根岸英雄 (60514297)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 生島弘彬 (80719154)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 橋爪洋 (10326382)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 小松紀子 (20553358)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 吉村典子 (60240355)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 岡田随象 (70727411)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 住友秀次 (20392996)

# of Collaborated Projects: 1 results

# of Collaborated Products: 19 results
21. 高柳広 (20334229)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 鈴木穣 (40323646)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 北條宏徳 (80788422)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 寺島明日香 (30596937)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 宮前多佳子 (90322354)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 井上祐三朗 (00456063)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 川上英良 (30725338)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 遠藤裕介 (80612192)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 明谷早映子 (90820598)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. MORITA KAORU

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
31. TERUYA SHUZO

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
32. TSUCHIDA Yumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. OKAMOTO Akiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
34. SHODA Hirofumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 岩崎由希子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 土屋遥香

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
37. 澁谷美穂子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. 高地雄太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
39. 宮冬樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Fujio Keishi 藤尾 圭志

FUJIO Keishi 藤尾 圭志

Research Projects

Research Products

Co-Researchers

Establishment of an integrated locomotive science including spatiotemporal dynamics of bone-articular cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of immunogenetic features of childhood-onset SLE by referencing adult peripheral blood single-cell data using AI

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research on creating a governance structure to manage research integrity risks in university-originated startup ecosystems

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanisms of pathogenic B cell differentiation associated with genetic risk for systemic lupus erythematosus.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of an integrated locomotive science including dynamics of bone-articular cells and regulation by immune system

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of pathogenesis of autoimmune-mediated interstitial lung disease based on epigenomic analysis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of epigenetic structure responsible for inflammatory mediator production from rheumatoid arthritis synovial fibroblastPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Inhibitory cytokine-producing Treg-mediated control of autoimmunityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the host's homeostatic responses by the regulation of immune system and its application to the prevention and treatment of immunological disorders

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Construction of an analysis system for antigen-specific immune response in human autoimmunityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of Egr2-expressing regulatory T cells in mice and humanPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Comparison analysis of two different human regulatory T cell populationsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of a novel regulatory T cell subset associated with a T cell anergy inducing genePrincipal Investigator

Principal Investigator

Project Period (FY)

Fujio Keishi 藤尾圭志

FUJIO Keishi 藤尾圭志

[Book] 医学のあゆみサイトカインのすべて 271巻5号　「IL-10ファミリーによる免疫制御機構」2019