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Nakatsugawa Munehide  中津川 宗秀

ORCIDConnect your ORCID iD *help
Researcher Number 70448596
Affiliation (Current) 2025: 東京医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2021 – 2022: 東京医科大学, 医学部, 教授
2019 – 2021: 東京医科大学, 医学部, 准教授
2017 – 2019: 札幌医科大学, 医学部, 助教
Review Section/Research Field
Principal Investigator
Basic Section 49070:Immunology-related
Except Principal Investigator
Basic Section 50020:Tumor diagnostics and therapeutics-related / Human pathology
Keywords
Principal Investigator
免疫 / ディープラーニング / T細胞 / T細胞受容体 / 細胞受容体 / 分子モデリング / ペプチド/抗原提示分子複合体 / 構造解析 / 腫瘍免疫 / molecular modeling / T cell receptor … More
Except Principal Investigator
… More 次世代シーケンシング / 個別化治療 / 病理診断 / 人工知能による深層機械学習システム / 乳がん / 個別化医療 / 免疫染色 / 人工知能 / 乳癌 / 細胞・組織 / 分子生物学 / 免疫学 / 腫瘍学 / 病理学 / Tumor antigen / 免疫病理診断 / 腫瘍免疫 / Immunohistochemistry / Immune response / Tumor immune escape / Single cell analysis / Cancer stem cell / Tumor microenvironment / 免疫病理バイオマーカー / 単細胞遺伝子発現解析 / がん免疫応答 / がん組織微小環境 / 腫瘍組織微小環境 / 免疫チェックポイント阻害剤 / がん抗原 / シングルセル遺伝子解析 / がん幹細胞 / 単細胞遺伝子解析 / がん最適化治療 / バイオマーカー / 免疫組織染色 / がん免疫療法 / T細胞抗原受容体 / 腫瘍微小環境 Less
  • Research Projects

    (3 results)
  • Research Products

    (28 results)
  • Co-Researchers

    (15 People)
  •  Construction of Breast Cancer Tissue Image Analysis Algorithm Using Deep Machine Learning System with Artificial Intelligence

    • Principal Investigator
      KAI Masaya
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Kyushu University
  •  Development of T-cell receptor ligand identification technology using deep learningPrincipal Investigator

    • Principal Investigator
      Nakatsugawa Munehide
    • Project Period (FY)
      2018 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49070:Immunology-related
    • Research Institution
      Tokyo Medical University
      Sapporo Medical University
  •  Basic research on the immunohistological categorization of tumor microenvironment

    • Principal Investigator
      TORIGOE Toshihiko
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Human pathology
    • Research Institution
      Sapporo Medical University

All 2021 2020 2019 2018 2017

All Journal Article Presentation

  • [Journal Article] Peptide vaccinations elicited strong immune responses that were reboosted by anti-PD1 therapy in a patient with myxofibrosarcoma2020

    • Author(s)
      Tsukahara, T. Watanabe, K. Murata, K. Takahashi, A. Mizushima, E. Shibayama, Y. Kameshima, H. Hatae, R. Ohno, Y. Kawahara, R. Murai, A. Nakatsugawa, M. Kubo, T. Kanaseki, T. Hirohashi, Y. Terui, T. Asanuma, H. Hasegawa, T. Sato, N. Torigoe, T.
    • Journal Title

      Cancer immunology immunotherapy

      Volume: 69 Issue: 2 Pages: 189-197

    • DOI

      10.1007/s00262-019-02455-0

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H01540, KAKENHI-PROJECT-20H03807, KAKENHI-PROJECT-18K19458
  • [Journal Article] Immunohistological analysis of pancreatic carcinoma after vaccination with survivin 2B peptide: Analysis of an autopsy series.2019

    • Author(s)
      Kubo T, Tsurita G, Hirohashi Y, Yasui H, Ota Y, Watanabe K, Murai A, Matsuo K, Asanuma H, Shima H, Wada S, Nakatsugawa M, Kanaseki T, Tsukahara T, Mizuguchi T, Hirata K, Takemasa I, Imai K, Sato N, Torigoe T.
    • Journal Title

      Cancer Sci.

      Volume: 110 Issue: 8 Pages: 2386-2395

    • DOI

      10.1111/cas.14099

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10672, KAKENHI-PROJECT-17H01540
  • [Journal Article] Randomized phase II trial of survivin 2B peptide vaccination for patients with HLA-A24-positive pancreatic adenocarcinoma.2019

    • Author(s)
      Shima H, Tsurita G, Wada S, Hirohashi Y, Yasui H, Hayashi H, Miyakoshi T, Watanabe K, Murai A, Asanuma H, Tokita S, Kubo T, Nakatsugawa M, Kanaseki T, Tsukahara T, Nakae Y, Sugita O, Ito YM, Ota Y, Kimura Y, Kutomi G, Hirata K, Mizuguchi T, Imai K, Takemasa I, Sato N, Torigoe T.
    • Journal Title

      Cancer Sci.

      Volume: 110 Issue: 8 Pages: 2378-2385

    • DOI

      10.1111/cas.14106

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10672, KAKENHI-PROJECT-17H01540
  • [Journal Article] Upstream Position of Proline Defines Peptide-HLA Class I Repertoire Formation and CD8(+) T Cell Responses2019

    • Author(s)
      Hongo, A. Kanaseki, T. Tokita, S. Kochin, V. Miyamoto, S. Hashino, Y. Codd, A. Kawai, N. Nakatsugawa, M. Hirohashi, Y. Sato, N. Torigoe, T.
    • Journal Title

      Journal of immunology

      Volume: 202 Issue: 10 Pages: 2849-2855

    • DOI

      10.4049/jimmunol.1900029

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K19458, KAKENHI-PROJECT-17H01540
  • [Journal Article] Osteosarcoma‐initiating cells show high aerobic glycolysis and attenuation of oxidative phosphorylation mediated by LIN28B2019

    • Author(s)
      Mizushima Emi、Tsukahara Tomohide、Emori Makoto、Murata Kenji、Akamatsu Asuka、Shibayama Yuji、Hamada Shuto、Watanabe Yuto、Kaya Mitsunori、Hirohashi Yoshihiko、Kanaseki Takayuki、Nakatsugawa Munehide、Kubo Terufumi、Yamashita Toshihiko、Sato Noriyuki、Torigoe Toshihiko
    • Journal Title

      Cancer Science

      Volume: 111 Issue: 1 Pages: 36-46

    • DOI

      10.1111/cas.14229

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10974, KAKENHI-PROJECT-17H01540, KAKENHI-PROJECT-20H03807
  • [Journal Article] Clonal analysis revealed functional heterogeneity in cancer stem-like cell phenotypes in uterine endometrioid adenocarcinoma.2019

    • Author(s)
      Tabuchi Y, Hirohashi Y, Hashimoto S, Mariya T, Asano T, Ikeo K, Kuroda T, Mizuuchi M, Murai A, Uno S, Kawai N, Kubo T, Nakatsugawa M, Kanaseki T, Tsukahara T, Saito T, Torigoe T.
    • Journal Title

      Exp Mol Pathol

      Volume: 106 Pages: 78-88

    • DOI

      10.1016/j.yexmp.2018.11.013

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K11285, KAKENHI-PLANNED-17H06399, KAKENHI-PROJECT-16H05451, KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-17H01540
  • [Journal Article] ABCG2 expression is related to low 5-ALA photodynamic diagnosis (PDD) efficacy and cancer stem cell phenotype, and suppression of ABCG2 improves the efficacy of PDD2019

    • Author(s)
      Kawai Noriko、Hirohashi Yoshihiko、Ebihara Yuma、Saito Takuma、Murai Aiko、Saito Takahiro、Shirosaki Tomohide、Kubo Terufumi、Nakatsugawa Munehide、Kanaseki Takayuki、Tsukahara Tomohide、Shichinohe Toshiaki、Li Liming、Hirano Satoshi、Torigoe Toshihiko
    • Journal Title

      PLOS ONE

      Volume: 14 Issue: 5 Pages: 0216503-0216503

    • DOI

      10.1371/journal.pone.0216503

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K11285, KAKENHI-PROJECT-19K16822, KAKENHI-PROJECT-17H01540
  • [Journal Article] Cellular stress induces cancer stem-like cells through expression of DNAJB8 by activation of heat shock factor 12018

    • Author(s)
      Kusumoto Hiroki、Hirohashi Yoshihiko、Nishizawa Satoshi、Yamashita Masamichi、Yasuda Kazuyo、Murai Aiko、Takaya Akari、Mori Takashi、Kubo Terufumi、Nakatsugawa Munehide、Kanaseki Takayuki、Tsukahara Tomohide、Kondo Toru、Sato Noriyuki、Hara Isao、Torigoe Toshihiko
    • Journal Title

      Cancer Science

      Volume: 109 Issue: 3 Pages: 741-750

    • DOI

      10.1111/cas.13501

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H04722, KAKENHI-PROJECT-16H05451, KAKENHI-PROJECT-15K10606, KAKENHI-PROJECT-17H01540
  • [Journal Article] Differential bronchial epithelial response regulated by ΔNp63: a functional understanding of the epithelial shedding found in asthma2018

    • Author(s)
      Kubo Terufumi、Tsujiwaki Mitsuhiro、Hirohashi Yoshihiko、Tsukahara Tomohide、Kanaseki Takayuki、Nakatsugawa Munehide、Hasegawa Tadashi、Torigoe Toshihiko
    • Journal Title

      Laboratory Investigation

      Volume: 99 Issue: 2 Pages: 158-168

    • DOI

      10.1038/s41374-018-0132-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05451, KAKENHI-PROJECT-16K21249, KAKENHI-PROJECT-17H01540
  • [Journal Article] Development of a T-cell receptor multimer with high avidity for detecting a naturally presented tumor-associated antigen on osteosarcoma cells2018

    • Author(s)
      Watanabe Kazue、Tsukahara Tomohide、Toji Shingo、Saitoh Shogo、Hirohashi Yoshihiko、Nakatsugawa Munehide、Kubo Terufumi、Kanaseki Takayuki、Kameshima Hidekazu、Terui Takeshi、Sato Noriyuki、Torigoe Toshihiko
    • Journal Title

      Cancer Science

      Volume: 110 Issue: 1 Pages: 40-51

    • DOI

      10.1111/cas.13854

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05451, KAKENHI-PROJECT-17H01540
  • [Journal Article] Brother of the regulator of the imprinted site (BORIS) variant subfamily 6 is a novel target of lung cancer stem-like cell immunotherapy2017

    • Author(s)
      Horibe, R. Hirohashi, Y. Asano, T. Mariya, T. Suzuki, T. Takaya, A. Saijo, H. Shionoya, Y. Kubo, T. Nakatsugawa, M. Kanaseki, T. Tsukahara, T. Watanabe, K. Atsuyama, E. Toji, S. Hirano, H. Hasegawa, T. Takahashi, H. Sato, N. Torigoe, T.
    • Journal Title

      PLoS One

      Volume: 12 Issue: 3 Pages: 0171460-0171460

    • DOI

      10.1371/journal.pone.0171460

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H01540
  • [Journal Article] Identification and functional analysis of variants of a cancer/testis antigen LEMD1 in colorectal cancer stem-like cells2017

    • Author(s)
      Takeda, R. Hirohashi, Y. Shen, M. Wang, L. Ogawa, T. Murai, A. Yamamoto, E. Kubo, T. Nakatsugawa, M. Kanaseki, T. Tsukahara, T. Nishidate, T. Okita, K. Kutomi, G. Sato, N. Takemasa, I. Torigoe, T.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 485 Issue: 3 Pages: 651-657

    • DOI

      10.1016/j.bbrc.2017.02.081

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H01540
  • [Journal Article] Implication of chemo-resistant memory T cells for immune surveillance in patients with sarcoma receiving chemotherapy.2017

    • Author(s)
      Shibayama Y, Tsukahara T, Emori M, Murata K, Mizushima E, Hirohashi Y, Kanaseki T, Nakatsugawa M, Kubo T, Yamashita T, Sato N, Torigoe T
    • Journal Title

      Cancer Science

      Volume: 108 Issue: 9 Pages: 1739-1745

    • DOI

      10.1111/cas.13319

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10974, KAKENHI-PROJECT-17H01540
  • [Journal Article] Mismatch Repair Protein Deficiency Is a Risk Factor for Aberrant Expression of HLA Class I Molecules: A Putative "Adaptive Immune Escape" Phenomenon2017

    • Author(s)
      Kubo, T. Hirohashi, Y. Matsuo, K. Sonoda, T. Sakamoto, H. Furumura, K. Tsukahara, T. Kanaseki, T. Nakatsugawa, M. Hirano, H. Furuhata, T. Takemasa, I. Hasegawa, T. Torigoe, T.
    • Journal Title

      Anticancer Res

      Volume: 37 Issue: 3 Pages: 1289-1295

    • DOI

      10.21873/anticanres.11446

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H01540
  • [Journal Article] Phosphorylation of HSF1 at serine 326 residue is related to the maintenance of gynecologic cancer stem cells through expression of HSP272017

    • Author(s)
      Yasuda, K. Hirohashi, Y. Mariya, T. Murai, A. Tabuchi, Y. Kuroda, T. Kusumoto, H. Takaya, A. Yamamoto, E. Kubo, T. Nakatsugawa, M. Kanaseki, T. Tsukahara, T. Tamura, Y. Hirano, H. Hasegawa, T. Saito, T. Sato, N. Torigoe, T.
    • Journal Title

      Oncotarget

      Volume: 8 Issue: 19 Pages: 31540-31553

    • DOI

      10.18632/oncotarget.16361

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H01540
  • [Journal Article] LY6/PLAUR domain containing 3 has a role in the maintenance of colorectal cancer stem-like cells2017

    • Author(s)
      Wang, L. Hirohashi, Y. Ogawa, T. Shen, M. Takeda, R. Murai, A. Yamamoto, E. Kubo, T. Nakatsugawa, M. Kanaseki, T. Tsukahara, T. Nishidate, T. Okita, K. Kutomi, G. Sato, N. Takemasa, I. Torigoe, T.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 486 Issue: 2 Pages: 232-238

    • DOI

      10.1016/j.bbrc.2017.02.112

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H01540
  • [Journal Article] GRIK2 has a role in the maintenance of urothelial carcinoma stem-like cells, and its expression is associated with poorer prognosis2017

    • Author(s)
      Inoue Ryuta、Hirohashi Yoshihiko、Kitamura Hiroshi、Nishida Sachiyo、Murai Aiko、Takaya Akari、Yamamoto Eri、Matsuki Masahiro、Tanaka Toshiaki、Kubo Terufumi、Nakatsugawa Munehide、Kanaseki Takayuki、Tsukahara Tomohide、Sato Noriyuki、Masumori Naoya、Torigoe Toshihiko
    • Journal Title

      Oncotarget

      Volume: 8 Issue: 17 Pages: 28826-28839

    • DOI

      10.18632/oncotarget.16259

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K10599, KAKENHI-PROJECT-17H01540
  • [Presentation] Deep Learningを用いた乳癌HE染色画像解析2021

    • Author(s)
      原田由利菜, 中津川宗秀, 久保真, 甲斐昌也, 山田舞, 森瞳美, 川地眸, 金城和寿, 林早織, 島﨑亜希子, 森崎隆史, 岩崎健, 山元英崇, 小田義直, 中村雅史
    • Organizer
      第57回九州外科学会
    • Data Source
      KAKENHI-PROJECT-20K07637
  • [Presentation] Deep Learning を用いた乳癌 HE 染色画像解析とタンパク発現予測に関する研究2021

    • Author(s)
      原田由利菜, 中津川宗秀, 久保真, 甲斐昌也, 山田舞, 森瞳美, 川地眸, 金城和寿, 林早織, 島﨑亜希子, 森崎隆史, 岩崎健, 山元英崇, 小田義直, 中村雅史
    • Organizer
      第121回日本外科学会定期学術集会
    • Data Source
      KAKENHI-PROJECT-20K07637
  • [Presentation] In silico TCR/pHLA結合評価システムの開発2020

    • Author(s)
      中津川宗秀、廣橋良彦、金関貴幸、久保輝文、塚原智英、村田憲治、鳥越俊彦
    • Organizer
      第24回がん免疫学会
    • Data Source
      KAKENHI-PROJECT-18K07180
  • [Presentation] Deep Learningを用いた乳癌HE染色画像解析とタンパク発現予測に関する研究2020

    • Author(s)
      原田由利菜, 久保真, 甲斐昌也, 山田舞, 森瞳美, 倉田加奈子, 川地眸, 金城和寿, 林早織, 島﨑亜希子, 森崎隆史, 小田義直, 中津川宗秀, 中村雅史,
    • Organizer
      第28回日本乳癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-20K07637
  • [Presentation] Identification of a new type of neoantigen derived from splice peptides2019

    • Author(s)
      Kato K, Nakatsugawa M, Kanaseki T, Tokita S, Torigoe T.
    • Organizer
      CRI-EATI-CIMT-AACR 5th International Cancer Immunotherapy Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H01540
  • [Presentation] 乳腺および甲状腺液状化検体細胞診におけるディープラーニングを利用した良悪性判定2019

    • Author(s)
      中津川 宗秀
    • Organizer
      第60回日本臨床細胞学会総会
    • Data Source
      KAKENHI-PROJECT-18K07180
  • [Presentation] Proteogenomic approach for natural HLA class I ligand peptides of cancer cells.2019

    • Author(s)
      Torigoe T, Kanaseki T, Hirohashi Y, Tsukahara T, Nakatsugawa M, Kubo T, Shinkawa T.
    • Organizer
      EMBL Conference: Cancer Genomics
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H01540
  • [Presentation] 乳腺液状化細胞診におけるディープラーニングを用いた良悪性判定2019

    • Author(s)
      中津川 宗秀
    • Organizer
      第108回日本病理学会総会
    • Data Source
      KAKENHI-PROJECT-18K07180
  • [Presentation] TCR/pHLA結合評価システムの開発2019

    • Author(s)
      中津川 宗秀
    • Organizer
      第23回日本がん免疫学会総会
    • Data Source
      KAKENHI-PROJECT-18K07180
  • [Presentation] ディープラーニングを用いた乳腺液状化細胞診における乳がん診断2018

    • Author(s)
      中津川 宗秀
    • Organizer
      第77回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K07180
  • [Presentation] ディープラーニングを用いたセンチネルリンパ節迅速病理画像診断2018

    • Author(s)
      中津川 宗秀
    • Organizer
      第107回日本病理学会総会
    • Data Source
      KAKENHI-PROJECT-18K07180
  • 1.  TORIGOE Toshihiko (20301400)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 12 results
  • 2.  KAI Masaya (10755242)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 3.  橋本 真一 (00313099)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  廣橋 良彦 (30516901)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 9 results
  • 5.  塚原 智英 (20404634)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 11 results
  • 6.  金関 貴幸 (50531266)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
  • 7.  久保 輝文 (90580019)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
  • 8.  中村 雅史 (30372741)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 9.  久保 真 (60403961)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 10.  小田 義直 (70291515)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 11.  MASUMORI Naoya
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  水口 徹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 13.  江森 誠人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 14.  北村 寛
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 15.  斉藤 豪
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results

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