Tsutsumi Naotaka 堤尚孝

Researcher Number	70963495
Other IDs	https://orcid.org/0000-0002-3617-7145
Affiliation (Current)	2025: 東京科学大学, 総合研究院, 特任准教授
Affiliation (based on the past Project Information) *help	2025: 東京科学大学, 総合研究院, 特任准教授 2024: 東京医科歯科大学, 高等研究院, 特任准教授 2022 – 2024: 岡山大学, 医歯薬学域, 助教
Review Section/Research Field	Principal Investigator Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Basic Section 43020:Structural biochemistry-related / 0701:Biology at molecular to cellular levels, and related fields Except Principal Investigator Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Medium-sized Section 47:Pharmaceutical sciences and related fields
Keywords	Principal Investigator クライオ電子顕微鏡 / 膜タンパク質 / 難生産性タンパク質 / 可溶性タンパク質 / タンパク質工学 / 難発現性タンパク質 / アレスチン / Gタンパク質 / ケモカイン / クラスA GPCR … More / 構造生物学 / GPCR / TAS2R / 苦味 / 受容体 / クライオEM / 苦味受容体 … More Except Principal Investigator 作動薬 / GPCR / ハロゲンイオン / 味覚受容体 / バイスシグナリング / 単粒子解析 / クライオ電子顕微鏡 / バイアスシグナリング / グレリン受容体 / Gタンパク質共役受容体 Less

G13共役型デザイナーGPCRの開発と遺伝薬理学論の概念実証
- Principal Investigator
  
  井上飛鳥
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Kyoto University
Structural study of the initial transducer engagement by GPCRPrincipal Investigator
- Principal Investigator
  
  堤尚孝
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Okayama University
Analysis of molecular functions and physiological roles of halogen-ion sensing by T1r taste receptors
- Principal Investigator
  
  山下敦子
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Okayama University
Establishing protein engineering approaches for production of difficult-to-express proteinsPrincipal Investigator
- Principal Investigator
  
  堤尚孝
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Tokyo Medical and Dental University
Structure-function analysis of human bitter taste receptorsPrincipal Investigator
- Principal Investigator
  
  Tsutsumi Naotaka
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0701:Biology at molecular to cellular levels, and related fields
- Research Institution
  Okayama University
グレリン受容体のシグナル伝達選択機構の構造基盤
- Principal Investigator
  
  浅田秀基
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Kyoto University

All 2024 2023 2022

All Journal Article Presentation Book

[Book] 生物物理2023年63巻6号2024
- Author(s)
  堤尚孝
- Total Pages
  4
- Publisher
  日本生物物理学会
- Data Source
  KAKENHI-PROJECT-22K20632
[Book] 実験医学2024年9月号2023
- Author(s)
  堤尚孝
- Total Pages
  3
- Publisher
  羊土社
- ISBN
  9784758125772
- Data Source
  KAKENHI-PROJECT-22K20632
[Book] 実験医学2022年9月号2022
- Author(s)
  堤尚孝
- Total Pages
  4
- Publisher
  羊土社
- ISBN
  9784758125598
- Data Source
  KAKENHI-PROJECT-22K20632
[Journal Article] Structural insight into guanylyl cyclase receptor hijacking of the kinase?Hsp90 regulatory mechanism2023
- Author(s)
  Caveney Nathanael A、Tsutsumi Naotaka、Garcia K Christopher
- Journal Title
  
  eLife
  
  Volume: 12
- DOI
  10.7554/elife.86784.3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K20632
[Journal Article] Structure and mechanism of oxalate transporter OxlT in an oxalate-degrading bacterium in the gut microbiota2023
- Author(s)
  Jaunet-Lahary Titouan、Shimamura Tatsuro、Hayashi Masahiro、Nomura Norimichi、Hirasawa Kouta、Shimizu Tetsuya、Yamashita Masao、Tsutsumi Naotaka、Suehiro Yuta、Kojima Keiichi、Sudo Yuki、Tamura Takashi、Iwanari Hiroko、Hamakubo Takao、Iwata So、Okazaki Kei-ichi、Hirai Teruhisa、Yamashita Atsuko
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 1730-1730
- DOI
  10.1038/s41467-023-36883-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03195, KAKENHI-PROJECT-20K21392, KAKENHI-PROJECT-20K21482, KAKENHI-PROJECT-18H02388, KAKENHI-PUBLICLY-21H00404, KAKENHI-PROJECT-23K18239, KAKENHI-PROJECT-22K20632, KAKENHI-PLANNED-19H05777, KAKENHI-PROJECT-19H00923, KAKENHI-PROJECT-21H02414, KAKENHI-PROJECT-21H02446, KAKENHI-PROJECT-23K27415
[Journal Article] Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for coreceptor discrimination2023
- Author(s)
  Tsutsumi Naotaka、Hwang Sunhee、Waghray Deepa、Hansen Simon、Jude Kevin M.、Wang Nan、Miao Yi、Glassman Caleb R.、Caveney Nathanael A.、Janda Claudia Y.、Hannoush Rami N.、Garcia K. Christopher
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 120 Issue: 11
- DOI
  10.1073/pnas.2218238120
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K20632
[Journal Article] Structural basis of Janus kinase trans-activation2023
- Author(s)
  Caveney Nathanael A.、Saxton Robert A.、Waghray Deepa、Glassman Caleb R.、Tsutsumi Naotaka、Hubbard Stevan R.、Garcia K. Christopher
- Journal Title
  
  Cell Reports
  
  Volume: 42 Issue: 3 Pages: 112201-112201
- DOI
  10.1016/j.celrep.2023.112201
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K20632
[Journal Article] Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis2023
- Author(s)
  Tsutsumi Naotaka、Masoumi Zahra、James Sophie C.、Tucker Julie A.、Winkelmann Hauke、Grey William、Picton Lora K.、Moss Lucie、Wilson Steven C.、Caveney Nathanael A.、Jude Kevin M.、Gati Cornelius、Piehler Jacob、Hitchcock Ian S.、Garcia K. Christopher
- Journal Title
  
  Cell
  
  Volume: 186 Issue: 19 Pages: 4189-4203.e22
- DOI
  10.1016/j.cell.2023.07.037
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K20632
[Journal Article] Viral G Protein-Coupled Receptors Encoded by β- and γ-Herpesviruses2022
- Author(s)
  Rosenkilde Mette M.、Tsutsumi Naotaka、Knerr Julius M.、Kildedal Dagmar F.、Garcia K. Christopher
- Journal Title
  
  Annual Review of Virology
  
  Volume: 9 Issue: 1 Pages: 329-351
- DOI
  10.1146/annurev-virology-100220-113942
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K20632
[Journal Article] Structure of the IL-27 quaternary receptor signaling complex2022
- Author(s)
  Caveney Nathanael A、Glassman Caleb R、Jude Kevin M、Tsutsumi Naotaka、Garcia K Christopher
- Journal Title
  
  eLife
  
  Volume: 11
- DOI
  10.7554/elife.78463
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K20632
[Journal Article] Organizing structural principles of the IL-17 ligand-receptor axis2022
- Author(s)
  Wilson Steven C.、Caveney Nathanael A.、Yen Michelle、Pollmann Christoph、Xiang Xinyu、Jude Kevin M.、Hafer Maximillian、Tsutsumi Naotaka、Piehler Jacob、Garcia K. Christopher
- Journal Title
  
  Nature
  
  Volume: 609 Issue: 7927 Pages: 622-629
- DOI
  10.1038/s41586-022-05116-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K20632
[Journal Article] Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation2022
- Author(s)
  Glassman Caleb R.、Tsutsumi Naotaka、Saxton Robert A.、Lupardus Patrick J.、Jude Kevin M.、Garcia K. Christopher
- Journal Title
  
  Science
  
  Volume: 376 Issue: 6589 Pages: 163-169
- DOI
  10.1126/science.abn8933
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K20632
[Presentation] Wnt-Frizzled-LRP6複合体の構造が明らかにした古典的β-カテニンシグナルの開始機構2023
- Author(s)
  堤尚孝
- Organizer
  第23回日本蛋白質科学年会
- Invited
- Data Source
  KAKENHI-PROJECT-22K20632
[Presentation] Structural evolution of human cytomegalovirus GPCRs US27 and US282023
- Author(s)
  Naotaka Tsutsumi
- Organizer
  The 4th European Chemokine and Cell Migration Conference (ECMC2023)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0099
[Presentation] Structural evolution of human cytomegalovirus GPCRs US27 and US282023
- Author(s)
  Naotaka Tsutsumi
- Organizer
  The 4th European Chemokine and Cell Migration Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K20632
[Presentation] サイトカインと腫瘍性変異によるヤヌスキナーゼの活性化機構2023
- Author(s)
  堤尚孝
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K20632
[Presentation] Structural mechanism of Janus kinase activation2022
- Author(s)
  Naotaka Tsutsumi
- Organizer
  第20回蛋白研リトリート
- Invited
- Data Source
  KAKENHI-PROJECT-22K20632

1. 椎村祐樹 (40551297)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 浅田秀基 (20399041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 林到ヒョン (50721883)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 山下敦子 (10321738)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 井上飛鳥 (50525813)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Tsutsumi Naotaka 堤 尚孝

Research Projects

Research Products

Co-Researchers

G13共役型デザイナーGPCRの開発と遺伝薬理学論の概念実証

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structural study of the initial transducer engagement by GPCRPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of molecular functions and physiological roles of halogen-ion sensing by T1r taste receptors

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishing protein engineering approaches for production of difficult-to-express proteinsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structure-function analysis of human bitter taste receptorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

グレリン受容体のシグナル伝達選択機構の構造基盤

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 生物物理2023年63巻6号2024

Author(s)

Total Pages

Publisher

Data Source

[Book] 実験医学2024年9月号2023

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 実験医学2022年9月号2022

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Structural insight into guanylyl cyclase receptor hijacking of the kinase?Hsp90 regulatory mechanism2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structure and mechanism of oxalate transporter OxlT in an oxalate-degrading bacterium in the gut microbiota2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for coreceptor discrimination2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural basis of Janus kinase trans-activation2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis2023

Author(s)

Journal Title

Tsutsumi Naotaka 堤尚孝