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Ohtsuka Eiko  大塚 榮子

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… Alternative Names

大塚 榮子  オオツカ エイコ

OHTSUKA Eiko  大塚 栄子

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Researcher Number 80028836
External Links
Affiliation (Current) 2025: 国立研究開発法人産業技術総合研究所, その他部局等, 研究員
Affiliation (based on the past Project Information) *help 2003: 独立行政法人産業技術総合研究所, フェロー研究員
1998: Graduate School of Pharmaceutical Sciences, Hokkaido University, Professor, 大学院・薬学研究科, 教授
1998: 北海道大学, 大学院薬学研究科, 教授
1986 – 1997: Hokkaido University Fac.of Pharmaceutical Sciences, Prof, 薬学部, 教授
1992: 北道海大学, 薬学部, 教授
1990: 北海道大, 薬学部, 教授
1985: 北海道大学, 薬, 教授
Review Section/Research Field
Principal Investigator
Biological pharmacy / 医薬分子機能学 / Chemical pharmacy / Living organism molecular science / Chemistry
Except Principal Investigator
Chemical pharmacy / 代謝生物化学 / 遺伝学 / 物質生物化学
Keywords
Principal Investigator
RNA / チミンダイマー / 合成遺伝子 / UV-damaged DNA / 紫外線損傷DNA / NMR / リボザイム / オリゴヌクレオチド / siRNA / OPN … More / モノクローナル抗体 / ras遺伝子 / 核酸高次構造 / Chimeric oligonucleotide / 2'-O-Methyloligoribonucleotide / RNA・modified DNA hybrid / RNase H / Sequence-specific cleavage of RNA / Site-specific cleavage of RNA / )f> / 大腸菌tRNA<Met( / 2′-O-メチルオリゴリボヌクレオチド / 大腸菌tRNA<met(\)f> / キメラオリゴヌクレオチド / 2'-0-メチルオリゴリボヌクレオチド / RNA・修飾DNAハイブリド / 大腸菌RNaseH / RNAの塩基配列特異的切断 / RNAの位置特異的切断 / GDP binding activity / Monoclonal antibodies / Synthetic gene / c-Ha-ras gene / GDP結合蛋白質 / P21 / GTPase活性 / GDP結合活性 / C-Ha-ras遺伝子 / Oligonucleotide / condensing reagent / Phosphotriester method / シアステレオマー / 縮合剤 / リン酸トリエステル法 / oligonucleotide / hepatitis / concanavarin A / metastasis / Osteopontin / リン酸化糖タンパク質 / 炎症疾患 / RNAi / 癌転移 / Concanavalin A / 肝炎 / concanavalin A / 転移 / オステオポンチン / X-ray crystallography / Single-chain antibody / Molecular recognition / X線結晶学 / 合成DNA / 抗光損傷DNA抗体 / 光損傷DNA / X線結晶構造解析 / 1本鎖抗体 / 分子認識 / ELISA / Dewar isomer / (6-4) photo product / thymine dimer / single-chain antibody / monoclonal antibody / Dewar型変性体 / ELISA法 / Dewar型異性体 / (6-4)光産物 / 一本鎖抗体 / Flexible Linker / Single Chain Antibody / PCR Cloning / Thymine Dimer / フレキシブルリンカー / シングル鎖抗体 / PCRクローニング / NIH3T3 cell / cell transformation / ras gene / Bio-catalysis / RNA enzyme / トランスフォ-メ-ション / RNA切断 / NIH3T3細胞 / N1H3T3細胞 / 細胞癌化 / 生体触媒 / RNA酵素 / NMR spectrum / CD spectrum / structure analysis / kinetic parameter / synthetic oligonucleotide / self-cleavage reaction / hammerhead-type ribozyme / オリゴリボヌクレオチド / NMRスペクトル / CDスペクトル / 構造解析 / 酵素活性 / 化学合成オリゴヌクレオチド / 自己切断反応 / ハンマ-ヘッド型リボザイム / 大腸菌トリプトファンプロモーター / T4エンドヌクレアーゼ【V】 / アミノ酸置換 / 結合酵素 / デオキシ核酸 / N1H3T3 / DNA修復 / 損傷DNA / アンチセンス核酸 / 核酸水素給合 / 核酸合成 / DNAプローブ / 核酸ループ / インターカレーター / 機能性核酸 / X線結晶解析 / 触媒RNA / RNA化学合成 / アベ-シックDNA / DNAエンドヌクレア-ゼ / DNAグリコシダ-ゼ / T4エンドヌクレア-ゼV / DNA切断酵素 / DNA修復酵素 / チミンフォトダイマ- … More
Except Principal Investigator
オリゴヌクレオチド / 核酸 / 蛋白質工学 / 蛋白質 / チミンダイマー / T4エンドヌクレアーゼV / NMR / 遺伝子 / DNA / RNA / 構造 / 部位特異的変異 / X-ray crystallography / cDNA / 核酸の化学合成 / X線結晶解析 / メチル化保護法 / ホスホロチオエート / 分子設計 / 有機化学 / 機能 / イントロン / 酵素ー基質複合体 / チミンダイマ- / T4エンドヌクレア-ゼV / レトロポゾン / ガングリオシド / 分泌シグナル配列 / Esperamicin / Opioid receptor / Peptide synthesis / Chiral synthesis / Modified oligonucleotide / P-450 model / Retinoid / Chiral 5-deazaflavin / 生物活性物質 / 生物有機化学 / レセプター / 作用機序の解明 / 機能性分子の合成 / ヒトパンクレオスタチン / 5-デアザフラビン / ペプチヂ合成 / 修飾オリゴフクレオチド / P-450モデル / 面不斉5-デアザフラビン / エスペラミシン / 不斉合成 / オピオイド受容体 / レチノイド / ペプチド合成 / Pー450モデル / 5ーデアザフラビン / Donor site / Exon / Intron / Pre-mRNA splicing / 2'-o-methylated oligonucleotides / スキャニングモデル / site / donor / エクソン / mRNAスプライシング / メチル化オリゴヌクレオチド / FLUOROCHROME / NUCLEIC ACID DETECTION / アビジン・ビオチン法 / 蛍光基質 / 核酸検出法 / RNase Tl / High resolution NMR / Substrate recognition mechanism / Chemically synthesized nucleic acids / 2次元NMR / X線結晶構造 / 構造活性相関 / 構造認識 / 遺伝子発現調節蛋白質 / ペプチド鎖延長因子 / RNase【T_1】 / ×線構造解析 / 遺伝子発現調節蛋白質λ-cro / オペレーターDNAλO_R3 / RNaseT1 / 高分解能NMR / X線構造解析 / 基質認識機構 / 化学合成核酸 / Protein expression system / Comparative biochemistry / Chemical modification / Replacement of amino acid / Protein Engineering / ボ-マン・バ-ク型インヒビタ- / Znープロテア-ゼ / モジュ-ル / キメラタンパク質 / ATPase / Lー乳酸脱水素酵素 / 核酸修復酵素 / ATPase. / T4エンドヌクレア-ゼ / アロステリック現象 / 血液凝固因子 / NADHーシトクロムb5 / アルドラ-ゼ / タンパク質発現系 / 比較生化学 / 化学修飾 / アミノ酸置換 / タンパク質工学 / 9 Protein Recognition / Protein Structure / Proteins / Brain / Micromachine / Bioclectronics / Biocomputer / Biochip / Biosensor / マイクロマシン / バイオコンピュ-タ- / バイオエレクトロニクス / バイオチップ / バイオセンサ- / 分子認識 / 高次構造 / 遺伝子改変 / 酵素サブユニットの相互作用 / 酵素の耐熱性 / 酵素の化学修飾 / 蛋白質分泌 / ヌクレオシド / アスパルターゼ / プロテアーゼ / 酵素修飾 / クローニング / 遺伝子クローニング / エンドヌクレアーゼ / 除去修復 / 発がん / 修復酵素 / DNA修復 / DNA損傷 / アルキル化剤 / 酸化損傷 / 水酸ラジカル / X線照射 / 過マンガン酸カリウム / 8-オキソグアニン / メチルホスホネート / 紫外線損傷DNA / 酵素一基質複合体 / フィルターバインディングアッセイ / 機能性核酸 / アンチセンス核酸 / 核酸有機化学 / 核酸構造 / 2'ーフルオロチミジン / フィルタ-バインディングアッセイ / 反復配列 / 性決定 / 転移RNA / ドロソフィラ / スプライシング / リボザイム / ホスホロチオエ-ト / ホスホロジチオエ-ト / リン酸ジエステル / オリゴデオキシリボヌクレオチド / DNA合成 / 内在性ウィルス / ファージ / ハンマーヘッド / コピア / tRNA / サケ / グルコース脱水素酵素 / キモシン / トリプトファナーゼ / アクアライシン Less
  • Research Projects

    (39 results)
  • Co-Researchers

    (100 People)
  •  Investigation of regulatory mechanism of homeostasis using functional nucleic acids.Principal Investigator

    • Principal Investigator
      KOMATSU Yasuo, 大塚 榮子
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Living organism molecular science
    • Research Institution
      NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
  •  Elucidation of recognition mechanisms of antibodies specific for nucleic aicd derivativesPrincipal Investigator

    • Principal Investigator
      OHTSUKA Eiko
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for Specially Promoted Research
    • Review Section
      Chemistry
    • Research Institution
      Hokkaido University
  •  DNA中の8-オキソグアニンの酸化による周辺残基の変異

    • Principal Investigator
      井上 英夫
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University
  •  Recognition of DNA by thymine dimers specific antibodiesPrincipal Investigator

    • Principal Investigator
      INOUE Hideo, 大塚 栄子
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      医薬分子機能学
    • Research Institution
      Hokkaido University
  •  修飾オリゴヌクレオチドを用いた紫外線損傷DNA修復機構の解析

    • Principal Investigator
      森岡 弘志
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University
  •  機能の創生を目指すオリゴヌクレオチドの化学合成Principal Investigator

    • Principal Investigator
      大塚 栄子
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University
  •  紫外線誘発DNA損傷による発癌遺伝子活性化に関する研究-化学合成オリゴヌクレオチドを用いた部位特異的導入法によるアプローチPrincipal Investigator

    • Principal Investigator
      大塚 栄子
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Hokkaido University
  •  紫外線損傷塩基を含む化学合成オリゴヌクレオチドと修復酵素との相互作用の解析

    • Principal Investigator
      森岡 弘志
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University
  •  Photodamage repair of DNA by anti thymine dimer antibodyPrincipal Investigator

    • Principal Investigator
      OHTSUKA Eiko
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      医薬分子機能学
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  核酸の構造と機能の有機化学的展開(成果とりまとめ)

    • Principal Investigator
      畑 辻明
    • Project Period (FY)
      1992 – 1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Institute of Technology
  •  修飾オリゴヌクレオチドを用いたT4エンドヌクレアーゼVの基質認識機構の解析

    • Principal Investigator
      森岡 弘志
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University
  •  アンチセンス核酸の活性と水素結合の機能の研究Principal Investigator

    • Principal Investigator
      大塚 栄子
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Hokkaido University
  •  チミンダイマ-除去修復機構の合成DNAによる解析Principal Investigator

    • Principal Investigator
      大塚 栄子
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Hokkaido University
  •  RNAの新しい機能に関する研究

    • Principal Investigator
      岡田 典弘
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      University of Tsukuba
  •  機能の創生を目指すオリゴヌクレオチドの化学合成Principal Investigator

    • Principal Investigator
      大塚 栄子
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University
  •  核酸の構造と機能の有機化学的展開

    • Principal Investigator
      畑 辻明
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Institute of Technology
  •  修飾オリゴヌクレオチドを用いたT4エンドヌクレア-ゼVと基質の相互作用の解析

    • Principal Investigator
      森岡 弘志
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University
  •  Antisense Activities of Ribozymes in in vivoPrincipal Investigator

    • Principal Investigator
      OHTSUKA Eiko
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      Biological pharmacy
    • Research Institution
      Faculty of Pharmaceutical Sciences Hokkaido University
  •  チミンダイマ-除去修復機構の合成遺伝子による解析Principal Investigator

    • Principal Investigator
      大塚 栄子
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Hokkaido University
  •  T4エンドヌクレア-ゼVの基質認識機構の解析

    • Principal Investigator
      岩井 成憲
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University
  •  核酸の構造と機能の有機化学的展開

    • Principal Investigator
      畑 辻明
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Institution
      Tokyo Institute of Technology
  •  Japan-Germany/Japan-U. K. Cooperative Project on Bioscience with Special Reference to Protein Recognition

    • Principal Investigator
      TANIGUCHI Masaru
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Chiba University
  •  Multiple approaches for the establishment of the basis of Protein Engineering.

    • Principal Investigator
      IMOTO Taiji
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      物質生物化学
    • Research Institution
      Kyushu University
  •  酵素蛋白質の計画的改変のための基礎技術の確立

    • Principal Investigator
      別府 輝彦
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  RNAの新しい機能に関する研究

    • Principal Investigator
      岡田 典弘
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      University of Tsukuba
  •  Elucidation of the Mechanism for the Self-Cleavage Rection of RNA Using Chemically-Synthesized OligonucleotidesPrincipal Investigator

    • Principal Investigator
      OHTSUKA Eiko
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      Hokkaido University
  •  核酸および核酸構成成分の合成と生体機能に関する研究

    • Principal Investigator
      畑 辻明
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Tokyo Institute of Technology
  •  控訴蛋白質の計画的改変のための基礎技術の確立

    • Principal Investigator
      別府・輝彦 テルヒコ
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  酵素蛋白質の計画的改変のための基礎技術の確立

    • Principal Investigator
      別府 輝彦
    • Project Period (FY)
      1987
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  New Frontier in Bioorganic Chemistry Research

    • Principal Investigator
      YONEDA Fumio
    • Project Period (FY)
      1987 – 1989
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Kyoto University
  •  Development of site-specific RNA cleaving method using modified DNA splints-RNase H systemPrincipal Investigator

    • Principal Investigator
      OHTSUKA Eiko
    • Project Period (FY)
      1987 – 1988
    • Research Category
      Grant-in-Aid for Developmental Scientific Research
    • Research Field
      Biological pharmacy
    • Research Institution
      Hokkaido University
  •  合成遺伝子を用いるDNA修復酵素の機能の研究Principal Investigator

    • Principal Investigator
      大塚 栄子
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Hokkaido University
  •  Studies on the mechanisms of pre-mRNA splicing using synthetic oligonucleotides

    • Principal Investigator
      OHSHIMA Yasumi
    • Project Period (FY)
      1986 – 1987
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      代謝生物化学
    • Research Institution
      Kyushu University
      University of Tsukuba
  •  合成遺伝子を用いる腫瘍遺伝子産物の機能の研究Principal Investigator

    • Principal Investigator
      大塚 栄子
    • Project Period (FY)
      1985
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Hokkaido University
  •  INNOVATION OF A NON-RADIO-ACTIVE LABELLING SUBSTANCE FOR NUVLEIC ACIDS.

    • Principal Investigator
      HORR Hiroshi
    • Project Period (FY)
      1985 – 1987
    • Research Category
      Grant-in-Aid for Developmental Scientific Research
    • Research Field
      遺伝学
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  Development of cancer diagnosis using monoclonal antibodies specific for ras gene productsPrincipal Investigator

    • Principal Investigator
      OHTSUKA Eiko
    • Project Period (FY)
      1985 – 1986
    • Research Category
      Grant-in-Aid for Developmental Scientific Research
    • Research Field
      Biological pharmacy
    • Research Institution
      Hokkaido University
  •  アルキル化剤によるがん原性DNA変異の生起とその抑制機構

    • Principal Investigator
      関口 睦夫
    • Project Period (FY)
      1984 – 1986
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Kyushu University
  •  Expression of Chemically synthetic genes and structure-functon relationship of their proteins

    • Principal Investigator
      IKEHARA Morio
    • Project Period (FY)
      1984 – 1987
    • Research Category
      Grant-in-Aid for Specially Promoted Research
    • Research Institution
      Science University of Tokyo
      Osaka University
  •  Stereospecific synthesis of phosphotriesters by using new condensing reagentsPrincipal Investigator

    • Principal Investigator
      OHTSUKA Eiko
    • Project Period (FY)
      1984 – 1986
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Hokkaido University
      Osaka University
  • 1.  INOUE Hideo (80088856)
    # of Collaborated Projects: 17 results
    # of Collaborated Products: 0 results
  • 2.  IWAI Shigenori (10168544)
    # of Collaborated Projects: 10 results
    # of Collaborated Products: 0 results
  • 3.  MORIOKA Hiroshi (20230097)
    # of Collaborated Projects: 9 results
    # of Collaborated Products: 0 results
  • 4.  KAMIYA Hiroyuki (10204629)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 0 results
  • 5.  畑 辻明 (00016049)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 6.  関根 光雄 (40111679)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 7.  別府 輝彦 (80011873)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 8.  OHTA Takahisa (30011844)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 9.  松田 彰 (90157313)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 10.  金子 主税 (40013833)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 11.  UESUGI Seiichi (70028851)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 12.  MIURA Kazunobu (70001980)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 13.  NIKAIDO Osamu (60019669)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 14.  KOMATSU Yasuo (30271670)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 15.  徳重 正信 (20025266)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
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