Kon Shigeyuki 今重之

… Alternative Names

今重之コンシゲユキ

KON Shigeyuki 今重之

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Researcher Number	90344499
Other IDs
External Links
Affiliation (Current)	2025: 福山大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2025: 福山大学, 薬学部, 教授 2023: 福山大学, 薬学部, 教授 2016 – 2021: 福山大学, 薬学部, 教授 2013 – 2014: 北海道大学, 薬学研究科(研究院), 准教授 2012: 北海道大学, 薬学研究科(研究院), 助教 … More 2006: 北海道大学, 遺伝子制御研究所, 特任助教授 2005 – 2006: 北海道大学, 遺伝子病制御研究所, 講師 2005: 北海道大学, 遺伝子制御研究所, 特任教授 2004: 北海道大学, 遺伝子病制御研究所, 寄附研究部門教員 2004: Hokkaido University, Division of Matrix Medicine, Institute for Genetic Medicine, Associate professor, 遺伝子病制御研究所・マトリックスメディスン研究部門, 助教授 2003 – 2004: 北海道大学, 遺伝子病制御研究所・分子免疫部門, 助手 2002 – 2003: 北海道大学, 遺伝子病制御研究所, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 49030:Experimental pathology-related / Biological pharmacy / Pathological medical chemistry Except Principal Investigator Orthopaedic surgery / Basic Section 59040:Nutrition science and health science-related / Experimental pathology / Living organism molecular science / Experimental pathology / Biological pharmacy / Biological Sciences
Keywords	Principal Investigator インテグリン / 自己免疫疾患 / 細胞接着 / ネフロネクチン / 抗体 / スプライシングバリアント / 細胞外マトリックス / 翻訳後修飾 / TGF-β / インテグリン機能阻害 … More / Th17 / メチマゾール / 薬学 / 免疫学 / カルシウム結合タンパク質 / 細胞外基質 / サンドイッチELISAシステム / カルシウム結合 / 制御性B細胞 / がん転移 / インテグリン変異体 / 酵素阻害剤 / 分子生物学 / 抗体医薬 / NKT細胞 / BCG / 分子細胞生物学 / マクロファージ / 感染症 / α9β1インテグリン / オステオポンチン … More Except Principal Investigator siRNA / オステオポンチン / インテグリン / Osteopontin / 癌転移 / RNA / OPN / 自己免疫疾患 / アポトーシス / 細胞・組織 / インテグリンα8 / インテグリンαv / TGF-β1 / Nodule / 手掌腱膜 / デュピュイトラン拘縮 / 炎症回路 / 線維化 / Dupuytren拘縮 / integrin / rheumatoid arthritis / neutralizing antibody / RNAアプタマー / 脱接着 / 関節リウマチ / 中和抗体 / oligonucleotide / hepatitis / concanavarin A / metastasis / リン酸化糖タンパク質 / 炎症疾患 / RNAi / Concanavalin A / オリゴヌクレオチド / 肝炎 / concanavalin A / 転移 / caspase / steroid / Transgenic mice / Apoptosis / Thymocyte / カスペース / ステロイド / 遺伝子導入マウス / 胸腺細胞 / NF-κB / 癌 / NF-kappaB / STAT3 / 炎症 / サイトカイン / シグナル伝達 / 免疫 / がん / MMP13 / リモデリング / 力学的負荷 / 腱 / anoikis / DAP3 / DR6 / TNF Less

食品・栄養成分によるインテグリン発現抑制を介した自己免疫疾患への有効性
- Principal Investigator
  
  柴田紗知
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Okayama Prefectural University
its receptor in autoimmune diseasesFunctional analysis of the interaction between thrombin-cleaved nephronectin andPrincipal Investigator
- Principal Investigator
  
  今重之
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Fukuyama University
Development of next generation integrin inhibitor having a novel inhibitory mannerPrincipal Investigator
- Principal Investigator
  
  Kon Shigeyuki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Fukuyama University
Elucidation of the mechanism for regulatory B cell differentiation by nephronectin and establishment of a novel therapeutic strategy for autoimmune diseasesPrincipal Investigator
- Principal Investigator
  
  KON Shigeyuki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Fukuyama University
Analysis on the mechanism of fibrosis of the palmar fascia in Dupuytren's contracture
- Principal Investigator
  
  Matsui Yuichiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hokkaido University
Development of novel antibody drugs for inhibition of autoimmune diseases, based on integrin splicing variant functionsPrincipal Investigator
- Principal Investigator
  
  KON Shigeyuki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
癌・免疫疾患発症とシグナル異常：STAT3とNFーκBを中心として
- Principal Investigator
  
  松田正
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
腱・靭帯のリモデリングにおけるオステオポンチンの効果の解明と治療への応用
- Principal Investigator
  
  真島任史 (眞島任史)
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hokkaido University
Molecular basis for the control of intractable diseases through manipulation of osteopontin function.
- Principal Investigator
  
  UEDE Toshimitsu
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Experimental pathology
- Research Institution
  HOKKAIDO UNIVERSITY
TNFファミリー分子とサイトカインによるアポトーシスと増殖のシグナル伝達機構解明
- Principal Investigator
  
  MIYAZAKI Tadaaki
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
タンパク質分解酵素による細胞外基質修飾と癌転移Principal Investigator
- Principal Investigator
  
  今重之
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Hokkaido University
Investigation of regulatory mechanism of homeostasis using functional nucleic acids.
- Principal Investigator
  
  KOMATSU Yasuo, 大塚榮子
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
Molecular analysis of steroid-induced apoptosis and its relevance to disease pathogenesis.
- Principal Investigator
  
  UEDE Toshimitsu
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Hokkaido University

[Journal Article] Nephronectin influences EAE development by regulating the Th17/Treg balance via reactive oxygen species2022
- Author(s)
  Honda M, Segawa T, Ishikawa K, Maeda M, Saito Y, Kon S.
- Journal Title
  
  Am J Physiol Cell Physiol .
  
  Volume: 322(4) Issue: 4 Pages: C699-C711
- DOI
  10.1152/ajpcell.00376.2021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07492, KAKENHI-PROJECT-21K19321, KAKENHI-PLANNED-21H05270, KAKENHI-PROJECT-20H00488
[Journal Article] VCAM1-a4b1 integrin interaction mediates interstitial tissue reconstruction in 3-D re-aggregate culture of dissociated prepubertal mouse testicular cells2021
- Author(s)
  Abe K, Kon S, Kameyama H, Zhang J, Morohashi K, Shimamura K, Abe S-I
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 18332-18332
- DOI
  10.1038/s41598-021-97729-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06322, KAKENHI-PROJECT-19K07492, KAKENHI-PROJECT-20H03436, KAKENHI-PLANNED-17H06427
[Journal Article] Antibodies against nephronectin ameliorate anti‐type II collagen‐induced arthritis in mice2020
- Author(s)
  Kon Shigeyuki、Honda Machiko、Ishikawa Kiyoshi、Maeda Masahiro、Segawa Tatsuya
- Journal Title
  
  FEBS Open Bio
  
  Volume: 10 Issue: 1 Pages: 107-117
- DOI
  10.1002/2211-5463.12758
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07492
[Journal Article] Targeting myeloid-cell specific integrin α9β1 inhibits arterial thrombosis in mice2020
- Author(s)
  Dhanesha Nirav、Nayak Manasa K.、Doddapattar Prakash、Jain Manish、Flora Gagan D.、Kon Shigeyuki、Chauhan Anil K.
- Journal Title
  
  Blood
  
  Volume: 135 Issue: 11 Pages: 857-861
- DOI
  10.1182/blood.2019002846
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07492
[Journal Article] Targeting Myeloid-Specific Integrin α9β1 Improves Short and Long-Term Stroke Outcomes in Murine Models With Preexisting Comorbidities by Limiting Thrombosis And Inflammation2020
- Author(s)
  Dhanesha N, Jain M, Tripathi A, Doddapattar P, Chorawala M, Bathla G, Nayak MK, Ghatge M, Lentz SR, Kon S, Chauhan AK.
- Journal Title
  
  Circulation Research
  
  Volume: － Issue: 12 Pages: 1779-1794
- DOI
  10.1161/circresaha.120.316659
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07492
[Journal Article] Neutralizing antibody against osteopontin attenuates non-alcoholic steatohepatitis in mice.2020
- Author(s)
  Honda M, Kimura C, Uede T, Kon S
- Journal Title
  
  J Cell Commun Signal.
  
  Volume: － Issue: 2 Pages: 223-232
- DOI
  10.1007/s12079-020-00554-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07492
[Journal Article] Role of Nephronectin in Pathophysiology of Silicosis2019
- Author(s)
  Lee S, Honda M, Yamamoto S, Kumagai-Takei N, Yoshitome K, Nishimura Y, Sada N, Kon S, Otsuki T.
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Issue: 10 Pages: 2581-2581
- DOI
  10.3390/ijms20102581
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07492, KAKENHI-PROJECT-17K09171
[Journal Article] Lactobacillus helveticus SBT2171 Attenuates Experimental Autoimmune Encephalomyelitis in Mice.2018
- Author(s)
  Yamashita M, Ukibe K, Matsubara Y, Hosoya T, Sakai F, Kon S, Arima Y, Murakami M, Nakagawa H, Miyazaki T.
- Journal Title
  
  Front Microbiol
  
  Volume: 8 Pages: 2596-2596
- DOI
  10.3389/fmicb.2017.02596
- NAID
  120006414007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08221
[Journal Article] The role of α9β1 integrin and its ligands in the development of autoimmune diseases.2018
- Author(s)
  Kon S, Uede T.
- Journal Title
  
  J Cell Commun Signal.
  
  Volume: 12 Issue: 1 Pages: 333-342
- DOI
  10.1007/s12079-017-0413-7
- NAID
  120007018386
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08221
[Journal Article] A Novel α9 Integrin Ligand, XCL1/Lymphotactin, Is Involved in the Development of Murine Models of Autoimmune Diseases.2017
- Author(s)
  Matsumoto N, Kon S, Nakatsuru T, Miyashita T, Inui K, Saitoh K, Kitai Y, Muromoto R, Kashiwakura JI, Uede T, Matsuda T.
- Journal Title
  
  J Immunol.
  
  Volume: 199 Issue: 1 Pages: 82-90
- DOI
  10.4049/jimmunol.1601329
- NAID
  120007007782
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08221, KAKENHI-PROJECT-17K08263
[Journal Article] Anti-IL-17A blocking antibody reduces cyclosporinA-induced relapse in experimental autoimmune encephalomyelitis mice2016
- Author(s)
  Saitoh K, Kon S, Nakatsuru T, Inui K, Ihara T, Matsumoto N, Kitai Y, Muromoto R, Matsuda T
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 8 Pages: 139-45
- DOI
  10.1016/j.bbrep.2016.08.021
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K08221
[Journal Article] A new STAT3-binding partner, ARL3, enhances the phosphorylation and nuclear accumulation of STAT3.2016
- Author(s)
  Togi S, Muromoto R, Hirashima K, Kitai Y, Okayama T, Ikeda O, Matsumoto N, Kon S, Sekine Y, Oritani K, Matsuda T.
- Journal Title
  
  J Biol Chem.
  
  Volume: 印刷中 Issue: 21 Pages: 11161-11171
- DOI
  10.1074/jbc.m116.724849
- NAID
  120006219975
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460056, KAKENHI-PROJECT-26461444, KAKENHI-PROJECT-16K08221
[Journal Article] Signal-transducing adaptor protein-2 regulates macrophage migration into inflammatory sites during dextran sodium sulfate induced colitis.2014
- Author(s)
  Fujita N, Oritani K, Ichii M, Yokota T, Saitoh N, Okuzaki D, Sekine Y, Kon S, Muromoto R, Saitoh K, Yoshimura A, Matsuda T, Kanakura Y.
- Journal Title
  
  Eur J Immunol.
  
  Volume: 44 Issue: 6 Pages: 1791-1801
- DOI
  10.1002/eji.201344239
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590072, KAKENHI-PROJECT-25460056, KAKENHI-PROJECT-26461412, KAKENHI-PROJECT-26461420, KAKENHI-PROJECT-26461444
[Journal Article] A novel cryptic binding motif, LRSKSRSFQVSDEQY, in the C-terminal fragment of MMP-3/7-cleaved osteopontin as a novel ligand for α9β1 integrin is involved in the anti-type II collagen antibody-induced arthritis.2014
- Author(s)
  Kon S, Nakayama Y, Matsumoto N, Ito K, Kanayama M, Kimura C, Kouro H, Ashitomi D, Matsuda T, Uede T.
- Journal Title
  
  PLoS One.
  
  Volume: 9 Issue: 12 Pages: e116210-e116210
- DOI
  10.1371/journal.pone.0116210
- NAID
  120005540287
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590072
[Journal Article] The novel α4B murine α4 integrin splicing variant inhibits α4-dependent cell adhesion.2014
- Author(s)
  Kouro H, Kon S, Matsumoto N, Miyashita T, Kakuchi A, Ashitomi D, Saito K, Nakatsuru T, Togi S, Muromoto R, Matsuda T.
- Journal Title
  
  J Biol Chem.
  
  Volume: 289 Issue: 23 Pages: 16389-16398
- DOI
  10.1074/jbc.m114.553610
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590072, KAKENHI-PROJECT-25460056
[Journal Article] Signal-transducing adaptor protein-2 controls the IgE-mediated, mast cell-mediated anaphylactic responses.2014
- Author(s)
  Sekine Y, Nishida K, Yamasaki S, Muromoto R, Kon S, Kashiwakura J, Saitoh K, Togi S, Yoshimura A, Oritani K, Matsuda T
- Journal Title
  
  J Immunol
  
  Volume: 192 Issue: 8 Pages: 3488-3495
- DOI
  10.4049/jimmunol.1300886
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590576, KAKENHI-PROJECT-24590072, KAKENHI-PROJECT-25253071, KAKENHI-PROJECT-25460056
[Journal Article] Tyk2 is a therapeutic target for psoriasis-like skin inflammation.2014
- Author(s)
  Ishizaki　M, Muromoto R, Akimoto T, Sekine Y, Kon S, Diwan M, Maeda, H, Togi S, Shimoda K, Oritani K, Matsuda T.
- Journal Title
  
  Int. Immunol.
  
  Volume: 26 Issue: 5 Pages: 257-267
- DOI
  10.1093/intimm/dxt062
- NAID
  120005522324
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590072, KAKENHI-PROJECT-24590773, KAKENHI-PROJECT-25460056
[Journal Article] Jun activation domain-binding protein 1 (JAB1) is required for the optimal response to interferons.2013
- Author(s)
  Muromoto R, Nakajima M, Hirashima K, Hirao T, Kon S, Shimoda K, Oritani K, Matsuda T.
- Journal Title
  
  J Biol Chem
  
  Volume: 288 Issue: 43 Pages: 30969-30979
- DOI
  10.1074/jbc.m113.485847
- NAID
  120005397865
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591387, KAKENHI-PROJECT-24590072, KAKENHI-PROJECT-24590773, KAKENHI-PROJECT-25460056
[Journal Article] Y14 positively regulates TNF-α-induced NF-κB transcriptional activity via interacting RIP1 and TRADD beyond an exon junction complex protein.2013
- Author(s)
  Togi S, Shiga K, Muromoto R, Kato M, Souma Y, Sekine Y, Kon S, Oritani K, Matsuda T.
- Journal Title
  
  J Immunol
  
  Volume: 191 Issue: 3 Pages: 1436-1444
- DOI
  10.4049/jimmunol.1300501
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591387, KAKENHI-PROJECT-24590072, KAKENHI-PROJECT-25460056
[Journal Article] Signal-transducing adaptor protein-2 modulates Fas-mediated T cell apoptosis by interacting with caspase-8.2012
- Author(s)
  Sekine Y, et al
- Journal Title
  
  J Immunol
  
  Volume: 188 Issue: 12 Pages: 6194-6204
- DOI
  10.4049/jimmunol.1103467
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591062, KAKENHI-PROJECT-23390015, KAKENHI-PROJECT-23790067, KAKENHI-PROJECT-24590072, KAKENHI-PROJECT-24590773
[Journal Article] Loss of osteopontin perturbs the epithelial-mesenchymal transition in an injured mouse lens epithelium.2007
- Author(s)
  S.Saika, K.Shirai, O.Yamanaka, KI.Miyazaki, Y.Okada, A.Kitano, KC.Flanders, S.Kon, T.Uede, WW.Kao, SR.Rittling, DT.Denhardt, Y.Ohnishi
- Journal Title
  
  Lab Invest. 87
  
  Pages: 130-138
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16209014
[Journal Article] Suppression of the bacterial antigen-specific T cell response and the dendritic cell migration to the lymph nodes by osteopontin.2007
- Author(s)
  MD.Begum, M.Umemura, S.Kon, A.Yahagi, S.Hamada, K.Oshiro, K.Gotoh, A.Nishizono, T.Uede, G.Matsuzaki
- Journal Title
  
  Microbiol Immunol. 51
  
  Pages: 135-147
- NAID
  10020282178
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16209014
[Journal Article] The role of osteopontin in tendon tissue remodeling after denervation-induced mechanical stress deprivation.2007
- Author(s)
  N.Mori, T.Majima, N.Iwasaki, S.Kon, K.Miyakawa, C.Kimura, K.Tanaka, DT.Denhardt, S.Rittling, A.Minami, T.Uede
- Journal Title
  
  Matrix Biol. 26
  
  Pages: 42-53
- NAID
  120000961947
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16209014
[Journal Article] High plasma concentrations of osteopontin in patients with interstitial pneumonia.2005
- Author(s)
  J.Kadota, S.Mizunoe, K.Mito, H.Mukae, S.Yoshioka, K.Kawakami, Y.Koguchi, K.Fukushima, S.Kon, S.Kohno, A.Saito, T.Uede, M.Nasu
- Journal Title
  
  Respir Med. 99
  
  Pages: 111-117
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16209014
[Journal Article] Circulating interleukin-18 and osteopontin are useful to evaluate disease activity in patients with tuberculosis.2005
- Author(s)
  S.Inomata, N.Shijubo, S.Kon, M.Maeda, G.Yamada, N.Sato, S.Abe, T.TUede
- Journal Title
  
  Cytokine. 30
  
  Pages: 203-211
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16209014
[Journal Article] Osteopontin functionally activates dendritic cells and induces their differentiation towards a Th-1 polarizing phenotype.2005
- Author(s)
  AC.Renkl, J.Wussler, T.Ahrens, K.Thoma, S.Kon T.Uede, SF.Martin, JC.Simon, JM.Weiss
- Journal Title
  
  Blood. 106
  
  Pages: 946-955
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16209014
[Journal Article] Functional role of death associated protein 3 (DAP3) in anoikis.2004
- Author(s)
  T.Miyazaki, M.Shen, D.Fujikura, N.Tosa, S.Kon, T.Uede, JC.Reed
- Journal Title
  
  J Biol Chem. 279
  
  Pages: 44667-44672
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16209014
[Journal Article] Effect of osteopontin alleles on beta-grucan induced granuloma formation in the mouse liver.2004
- Author(s)
  K.Tanaka.J.Morimoto, S.Kon, C.Kimura, M.Inobe, H.Diao, G.Hirschfeld, J.M.Weiss, T.Uede
- Journal Title
  
  Am J Pathol. 164
  
  Pages: 567-575
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16209014
[Journal Article] Role of osteopontin in cardiac fibrosis and remodeling in angiotensin II-induced cardiac hypertrophy.2004
- Author(s)
  Y.Matsui, N.Jia, H.Okamoto, S.Kon, H.Onozuka, M.Akino, K.Liu, J.Morimoto, SR.Rittling, D.Denhardt, A.Kitabatake, T.Uede
- Journal Title
  
  Hypertension. 43
  
  Pages: 1195-1201
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16209014
[Journal Article] Osteopontin as a mediator of NKT cell function in T cell-mediated liver diseases.2004
- Author(s)
  H.Diao, S.Kon, K.Iwabuchi, C.Kimura, J.Morimoto, D.Ito, T.Segawa, M.Maeda, J.Hamuro, T.Nakayama, M.Taniguchi, H.Yagita, L.V.Kaer, K.Onoe, D.Denhardt, S.Rittling, T.Uede
- Journal Title
  
  Immunity. 21
  
  Pages: 539-550
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16209014
[Journal Article] Osteopontin affects the persistence of beta-glucan-induced hepatic granuloma formation and tissue injury through two distinct mechanisms.2004
- Author(s)
  J.Morimoto, M.Inobe, C.Kimura, S.Kon, H.Diao, M.Aoki, T.Miyazaki, DT.Denhardt, S.Rittling, T.Uede
- Journal Title
  
  Int Immunol. 16
  
  Pages: 477-488
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16209014
[Patent] 抗α9インテグリン抗体とその用途2006
- Inventor(s)
  黒滝大翼, 金山剛士, 今重之, 上出利光
- Industrial Property Rights Holder
  (株)ジーンテクノサイエンス
- Filing Date
  2006-01-12
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16209014
[Patent] オステオポンチンsiRNA2006
- Inventor(s)
  齋藤善也, 今重之, 上出利光
- Industrial Property Rights Holder
  (株)ジーンテクノサイエンス
- Filing Date
  2006-12-11
- Data Source
  KAKENHI-PROJECT-16209014
[Patent] 細胞外マトリックスタンパク質のアミノ酸配列RGDに対する抗体および製法と用途2006
- Inventor(s)
  今重之, 木村千恵美, 上出利光
- Industrial Property Rights Holder
  (株)ジーンテクノサイエンス
- Filing Date
  2006-10-26
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16209014
[Patent] 抗ヒトα9インテグリン抗体とその用途2006
- Inventor(s)
  金山剛士, 黒滝大翼, 今重之, 上出利光
- Industrial Property Rights Holder
  (株)ジーンテクノサイエンス
- Filing Date
  2006-07-12
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16209014
[Patent] 抗ヒトα9インテグリン抗体とその用途2006
- Inventor(s)
  金山剛士, 黒滝大翼, 今重之, 上出利光
- Industrial Property Rights Holder
  (株)ジーンテクノサイエンス
- Filing Date
  2006-07-12
- Data Source
  KAKENHI-PROJECT-16209014
[Patent] オステオポンチンsiRNA2006
- Inventor(s)
  齋藤善也, 今重之, 上出利光
- Industrial Property Rights Holder
  (株)ジーンテクノサイエンス
- Filing Date
  2006-12-11
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16209014
[Patent] 抗α9インテグリン抗体とその用途2006
- Inventor(s)
  黒滝大翼, 金山剛士, 今重之, 上出利光
- Industrial Property Rights Holder
  (株)ジーンテクノサイエンス
- Filing Date
  2006-01-12
- Data Source
  KAKENHI-PROJECT-16209014
[Patent] 細胞外マトリックスタンパク質のアミノ酸配列RGDに対する抗体および製法と用途2006
- Inventor(s)
  今重之, 木村千恵美, 上出利光
- Industrial Property Rights Holder
  (株)ジーンテクノサイエンス
- Filing Date
  2006-10-26
- Data Source
  KAKENHI-PROJECT-16209014
[Patent] 抗α9インテグリン抗体2005
- Inventor(s)
  黒滝大翼, 今重之, 上出利光
- Industrial Property Rights Holder
  (株)ジーンテクノサイエンス
- Filing Date
  2005-01-13
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16209014
[Patent] オステオポンチンsiRNA2005
- Inventor(s)
  齋藤善也, 今重之, 小松康雄, 上出利光
- Industrial Property Rights Holder
  生化学工業(株), (株)ジーンテクノサイエンス
- Filing Date
  2005-04-12
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16209014
[Patent] 腱・靱帯の劣化予防剤、治療剤2004
- Inventor(s)
  森律明, 岩崎倫政, 三浪明男, 今重之, 上出利光, 前田雅弘
- Industrial Property Rights Holder
  (株)免疫生物研究所, (株)ジーンテクノサイエンス
- Filing Date
  2004-11-04
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16209014
[Patent] 免疫担当細胞活性化阻害剤およびその用途2004
- Inventor(s)
  今重之, 上出利光, ディオコウエン
- Industrial Property Rights Holder
  (株)免疫生物研究所, (株)ジーンテクノサイエンス
- Filing Date
  2004-05-21
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16209014
[Presentation] トロンビン切断型ネフロネクチンは新たなインテグリン結合能を獲得する2021
- Author(s)
  本田真知子, 今重之
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07492
[Presentation] 細胞外基質ネフロネクチンに対する中和抗体はDSS誘導大腸炎を増悪化させる2021
- Author(s)
  髙原千穂、柴田紗知、本田真知子、髙山健人、今重之
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19K07492
[Presentation] 食品機能成分による肺がん転移予防効果2021
- Author(s)
  柴田紗知、高砂みゆき、石川裕菜、田中音寿、山田康平、今重之
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19K07492
[Presentation] 酒粕および酒粕含有成分による抗ストレス効果の検討2021
- Author(s)
  石川裕菜、高砂みゆき、今重之、柴田紗知
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19K07492
[Presentation] トロンビン切断型ネフロネクチンはα4、α9、β7インテグリン発現細胞と接着する2021
- Author(s)
  本田真知子、今重之
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19K07492
[Presentation] ネフロネクチンはCD4+T細胞内のROSを介したTh17とTregのバランス制御によってEAE増悪化に関与する2020
- Author(s)
  本田真知子、斎藤芳郎、今重之
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07492
[Presentation] 細胞外基質ネフロネクチンはCD4+T細胞内の活性酸素種（ROS）介したTh17/Tregバランス制御により自己免疫疾患増悪化に関与する2020
- Author(s)
  本田真知子、斎藤芳郎、今重之
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K07492
[Presentation] カルノシン酸及びピシフェリン酸の加齢性疾患予防効果2020
- Author(s)
  柴田紗知、海切弘子、桜井奏慧、前原昭次、浦大樹、硎澄仁、新井田要、萱島知子、味八木茂、松原主典、今重之
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K07492
[Presentation] 珪肺症の病態生理におけるネフロネクチンの役割2020
- Author(s)
  大槻　剛巳、武井　直子、伊藤　達夫、吉留　敬、西村　泰光、本田　真知子、今　重之、李順姫
- Organizer
  第90回日本衛生学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07492
[Presentation] 細胞外基質ネフロネクチンのT細胞内の活性酸素種（ROS）介したTh17とTregのバランス制御による自己免疫疾患増悪化に関する検討2020
- Author(s)
  本田真知子、斎藤芳郎、今重之
- Organizer
  第59回日本薬学会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-19K07492
[Presentation] 副作用軽減を期待できるメチマゾール類縁体を用いた自己免疫疾患抑制効果の検討2020
- Author(s)
  福永　真実、西山　卓志、本田　真知子、町枝　臣成、今　重之
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K07492
[Presentation] α4インテグリンスプライシングバリアントの結合分子の探索と機能解析2019
- Author(s)
  山田康平、本田真知子、今重之
- Organizer
  第58回日本薬学会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-19K07492
[Presentation] セレノプロテインPとの相互作用による細胞外基質ネフロネクチンのグルタチオンペルオキシダーゼ誘導の検討2019
- Author(s)
  本田真知子、斎藤芳郎、今重之
- Organizer
  第58回日本薬学会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-19K07492
[Presentation] 新規α4インテグリンスプライシングバリアントを用いた自己免疫疾患治療戦略2019
- Author(s)
  福永真実、本田真知子、今重之
- Organizer
  第58回日本薬学会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-19K07492
[Presentation] 自己免疫疾患における細胞外基質ネフロネクチンの関与2018
- Author(s)
  藤岡和征、本田真知子、松田正、今重之
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K08221
[Presentation] 新規α４インテグリンスプライシングバリアントは内在性α４インテグリン機能抑制分子である2018
- Author(s)
  重政歩美、乾恭輔、本田真知子、松田正、今重之
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K08221
[Presentation] 新たな反応性を有する抗β8インテグリン抗体を用いた肝線維化モデル抑制効果の検討2018
- Author(s)
  重政　歩美、本田　真知子、今　重之
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K08221
[Presentation] 抗オステオポンチン抗体を用いた非アルコール性脂肪肝炎増悪化抑制効果の検討2018
- Author(s)
  本田　真知子、宮崎　純子、今　重之
- Organizer
  第57回日本薬学会中国四国支部会
- Data Source
  KAKENHI-PROJECT-16K08221
[Presentation] 新規α4インテグリンスプライシングバリアントの同定とその機能解析2018
- Author(s)
  川崎　岬、重政　歩美、本田　真知子、今　重之
- Organizer
  第57回日本薬学会中国四国支部会
- Data Source
  KAKENHI-PROJECT-16K08221
[Presentation] The role of signal-transducing adaptor protein-1 in Concanavalin A-induced hepatitis2018
- Author(s)
  Takeru Ihara, Kodai Saitoh, Shigeyuki Kon, Junichi Kashiwakura, Ryuta Muromoto, Yuichi Kitai, Tadashi Matsuda
- Organizer
  第46回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-16K08221
[Presentation] 抗β8インテグリン抗体を用いた四塩化炭素誘導肝線維化モデル抑制効果の検討2018
- Author(s)
  重政　歩美、本田　真知子、今　重之
- Organizer
  第57回日本薬学会中国四国支部会
- Data Source
  KAKENHI-PROJECT-16K08221
[Presentation] 細胞外基質ネフロネクチンに対するサンドイッチELISAシステムの構築2018
- Author(s)
  本田真知子、李順姫、松田正、大槻剛巳、今重之
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K08221
[Presentation] Soluble alpha4 integrin splicing variant is a novel endogenous integrin inhibitor2016
- Author(s)
  Kon S, Inui K, Saitoh K, Matsumoto N, Matsuda T
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター（沖縄県、宜野湾市）
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-16K08221
[Presentation] T細胞活性化および免疫応答におけるSTAP-2の機能解析2016
- Author(s)
  齋藤浩大、今重之、小澤清貴、伊原建、関根勇一、室本竜太、鍛代悠一、吉村昭彦、織谷健司、松田正
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県、横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K08221
[Presentation] インテグリを介した細胞接着の機能抑制による自己免疫疾患治療戦略2016
- Author(s)
  今　重之
- Organizer
  第135回日本薬学会中国四国支部例会
- Place of Presentation
  福山大学（広島県、福山市）
- Invited
- Data Source
  KAKENHI-PROJECT-16K08221
[Presentation] XCL1/Lymphotactin, a novel ligand of alpha9 integrin, is involved in the development of autoimmune diseases2016
- Author(s)
  Matsumoto N, Kon S, Nakatsuru T, Matsuda T
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター（沖縄県、宜野湾市）
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-16K08221
[Presentation] 新規変異型α４インテグリンの同定と機能解析2014
- Author(s)
  宮下友惠、紅露ひとみ、松本尚樹、今重之、松田正
- Organizer
  日本薬学会北海道支部第141回例会
- Place of Presentation
  札幌
- Year and Date
  2014-05-24
- Data Source
  KAKENHI-PROJECT-24590072
[Presentation] Lymphotactinは新規α９インテグリンリガンドである2014
- Author(s)
  中鶴拓也、松本尚樹、紅露ひとみ、今重之、松田正
- Organizer
  日本薬学会北海道支部第141回例会
- Place of Presentation
  札幌
- Year and Date
  2014-05-24
- Data Source
  KAKENHI-PROJECT-24590072
[Presentation] 新規α４インテグリンバリアントはα４インテグリンの内在性機能阻害因子である2014
- Author(s)
  紅露ひとみ、松本尚樹、宮下友恵、中鶴拓也、今重之、松田正
- Organizer
  第51回日本生化学会北海道支部例会
- Place of Presentation
  札幌
- Year and Date
  2014-07-18
- Data Source
  KAKENHI-PROJECT-24590072
[Presentation] Identification of a novel alpha9 integrin ligand, lymphotactin2013
- Author(s)
  Naoki Matsumoto, Shigeyuki Kon, Tadashi Matsuda
- Organizer
  第42回日本免疫学会
- Place of Presentation
  千葉県幕張メッセ、千葉県
- Data Source
  KAKENHI-PROJECT-24590072
[Presentation] 細胞内配列の異なる新規変異型α４インテグリンは α４インテグリン依存性細胞接着を抑制する2013
- Author(s)
  紅露ひとみ、今重之、松田正
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸ポートアイランド、兵庫県
- Data Source
  KAKENHI-PROJECT-24590072
[Presentation] A novel secreted alpha4 integrin variant inhibits alpa4 and alpha9 integrin-dependent cell adhesion2013
- Author(s)
  Shigeyuki Kon and Tadashi Matsuda
- Organizer
  第42回日本免疫学会
- Place of Presentation
  千葉県幕張メッセ、千葉県
- Data Source
  KAKENHI-PROJECT-24590072
[Presentation] 細胞内配列の異なる新規変異型α４インテグリンの機能2013
- Author(s)
  紅露ひとみ、今重之、松田正
- Organizer
  日本薬学会第133年会
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Data Source
  KAKENHI-PROJECT-24590072
[Presentation] A novel murine α4 integrin splicing variant is a specific receptor for VCAM-12012
- Author(s)
  Kon S, Kouro H, Matsuda T
- Organizer
  The 99th AAI Annual Meeting
- Place of Presentation
  Hynes Convention Center, Boston, USA
- Data Source
  KAKENHI-PROJECT-24590072
[Presentation] α4インテグリンスプライシングバリアントによるインテグリン機能調節機構の解明と創薬への発展
- Author(s)
  今重之, 紅露ひとみ, 中鶴拓也, 宮下友惠, 松本尚樹, 松田正
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24590072
[Presentation] 新規α9インテグリンリガンドLymphotactinの同定と機能解析
- Author(s)
  中鶴拓也, 松本尚樹, 紅露ひとみ, 松田正, 今重之
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24590072

1. UEDE Toshimitsu (00160185)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
2. MIYAZAKI Tadaaki (60272431)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. KOMATSU Yasuo (30271670)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. KOJIMA Naoshi (30356985)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. ONO Etsurou (00160903)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. YOKOSAKI Yasuyuki (80210607)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Matsui Yuichiro (20374374)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 丸山光生 (00212225)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 岩渕和也 (20184898)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 真島任史 (30241334)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 岩崎倫政 (30322803)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 三浪明男 (20133738)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 松田正 (20212219)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 室本竜太 (30455597)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. 関根勇一 (20396295)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 南保明日香 (60359487)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 猪部学 (10312414)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 大塚榮子 (80028836)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 村上正晃 (00250514)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 船越忠直 (10528334)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 藤井文彦 (40374657)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 柴田紗知 (90803940)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 織谷健司

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
24. 安部真一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 西田圭吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kon Shigeyuki 今 重之

今 重之 コン シゲユキ

KON Shigeyuki 今 重之

Research Projects

Research Products

Co-Researchers

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

its receptor in autoimmune diseasesFunctional analysis of the interaction between thrombin-cleaved nephronectin andPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of next generation integrin inhibitor having a novel inhibitory mannerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

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Elucidation of the mechanism for regulatory B cell differentiation by nephronectin and establishment of a novel therapeutic strategy for autoimmune diseasesPrincipal Investigator

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Development of novel antibody drugs for inhibition of autoimmune diseases, based on integrin splicing variant functionsPrincipal Investigator

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タンパク質分解酵素による細胞外基質修飾と癌転移Principal Investigator

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[Journal Article] Nephronectin influences EAE development by regulating the Th17/Treg balance via reactive oxygen species2022

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Kon Shigeyuki 今重之

今重之コンシゲユキ

KON Shigeyuki 今重之