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Kon Shigeyuki  今 重之

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KON Shigeyuki  今 重之

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Researcher Number 90344499
Other IDs
External Links
Affiliation (Current) 2021: 福山大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help 2016 – 2019: 福山大学, 薬学部, 教授
2013 – 2014: 北海道大学, 薬学研究科(研究院), 准教授
2012: 北海道大学, 薬学研究科(研究院), 助教
2006: 北海道大学, 遺伝子制御研究所, 特任助教授
2005 – 2006: 北海道大学, 遺伝子病制御研究所, 講師 … More
2005: 北海道大学, 遺伝子制御研究所, 特任教授
2004: 北海道大学, 遺伝子病制御研究所, 寄附研究部門教員
2004: Hokkaido University, Division of Matrix Medicine, Institute for Genetic Medicine, Associate professor, 遺伝子病制御研究所・マトリックスメディスン研究部門, 助教授
2003 – 2004: 北海道大学, 遺伝子病制御研究所・分子免疫部門, 助手
2002 – 2003: 北海道大学, 遺伝子病制御研究所, 助手 Less
Review Section/Research Field
Principal Investigator
Biological pharmacy / Pathological medical chemistry / Basic Section 49030:Experimental pathology-related
Except Principal Investigator
Orthopaedic surgery / Biological Sciences / Biological pharmacy / Experimental pathology / Living organism molecular science / Experimental pathology
Keywords
Principal Investigator
インテグリン / 細胞接着 / 自己免疫疾患 / 細胞外マトリックス / スプライシングバリアント / 抗体 / オステオポンチン / α9β1インテグリン / 感染症 / マクロファージ … More / 分子細胞生物学 / BCG / NKT細胞 / 抗体医薬 / 分子生物学 / 酵素阻害剤 / インテグリン変異体 / がん転移 / ネフロネクチン / 制御性B細胞 / カルシウム結合 / サンドイッチELISAシステム / 細胞外基質 / カルシウム結合タンパク質 / 免疫学 / 薬学 / メチマゾール … More
Except Principal Investigator
オステオポンチン / siRNA / アポトーシス / OPN / RNA / 癌転移 / Osteopontin / TNF / DR6 / DAP3 / anoikis / 腱 / 力学的負荷 / リモデリング / MMP13 / がん / 免疫 / シグナル伝達 / サイトカイン / 炎症 / 自己免疫疾患 / STAT3 / NF-kappaB / 癌 / NF-κB / 胸腺細胞 / 遺伝子導入マウス / ステロイド / カスペース / Thymocyte / Apoptosis / Transgenic mice / steroid / caspase / 転移 / concanavalin A / 肝炎 / オリゴヌクレオチド / Concanavalin A / RNAi / 炎症疾患 / リン酸化糖タンパク質 / metastasis / concanavarin A / hepatitis / oligonucleotide / 中和抗体 / インテグリン / 関節リウマチ / 脱接着 / RNAアプタマー / neutralizing antibody / rheumatoid arthritis / integrin / Dupuytren拘縮 / 線維化 / 炎症回路 / デュピュイトラン拘縮 / 手掌腱膜 / Nodule / TGF-β1 / インテグリンαv / インテグリンα8 / 細胞・組織 Less
  • Research Projects

    (11 results)
  • Research Products

    (67 results)
  • Co-Researchers

    (29 People)
  •  新たな阻害作用機序を示す次世代抗インテグリン薬の開発Principal InvestigatorOngoing

    • Principal Investigator
      今 重之
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49030:Experimental pathology-related
    • Research Institution
      Fukuyama University
  •  Elucidation of the mechanism for regulatory B cell differentiation by nephronectin and establishment of a novel therapeutic strategy for autoimmune diseasesPrincipal Investigator

    • Principal Investigator
      KON Shigeyuki
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Fukuyama University
  •  Analysis on the mechanism of fibrosis of the palmar fascia in Dupuytren's contracture

    • Principal Investigator
      Matsui Yuichiro
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Orthopaedic surgery
    • Research Institution
      Hokkaido University
  •  Development of novel antibody drugs for inhibition of autoimmune diseases, based on integrin splicing variant functionsPrincipal Investigator

    • Principal Investigator
      KON Shigeyuki
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Hokkaido University
  •  癌・免疫疾患発症とシグナル異常:STAT3とNFーκBを中心として

    • Principal Investigator
      松田 正
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      Hokkaido University
  •  腱・靭帯のリモデリングにおけるオステオポンチンの効果の解明と治療への応用

    • Principal Investigator
      真島 任史 (眞島 任史)
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Orthopaedic surgery
    • Research Institution
      Hokkaido University
  •  Molecular basis for the control of intractable diseases through manipulation of osteopontin function.

    • Principal Investigator
      UEDE Toshimitsu
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Experimental pathology
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  TNFファミリー分子とサイトカインによるアポトーシスと増殖のシグナル伝達機構解明

    • Principal Investigator
      MIYAZAKI Tadaaki
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  タンパク質分解酵素による細胞外基質修飾と癌転移Principal Investigator

    • Principal Investigator
      今 重之
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Hokkaido University
  •  Investigation of regulatory mechanism of homeostasis using functional nucleic acids.

    • Principal Investigator
      KOMATSU Yasuo, 大塚 榮子
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Living organism molecular science
    • Research Institution
      NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
  •  Molecular analysis of steroid-induced apoptosis and its relevance to disease pathogenesis.

    • Principal Investigator
      UEDE Toshimitsu
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Hokkaido University

All 2020 2019 2018 2017 2016 2014 2013 2012 2007 2006 2005 2004 Other

All Journal Article Presentation Patent

  • [Journal Article] Neutralizing antibody against osteopontin attenuates non-alcoholic steatohepatitis in mice.2020

    • Author(s)
      Honda M, Kimura C, Uede T, Kon S
    • Journal Title

      J Cell Commun Signal.

      Volume: -

    • DOI

      10.1007/s12079-020-00554-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07492
  • [Journal Article] Targeting Myeloid-Specific Integrin α9β1 Improves Short and Long-Term Stroke Outcomes in Murine Models With Preexisting Comorbidities by Limiting Thrombosis And Inflammation2020

    • Author(s)
      Dhanesha N, Jain M, Tripathi A, Doddapattar P, Chorawala M, Bathla G, Nayak MK, Ghatge M, Lentz SR, Kon S, Chauhan AK.
    • Journal Title

      Circulation Research

      Volume: -

    • DOI

      10.1161/circresaha.120.316659

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07492
  • [Journal Article] Targeting myeloid-cell specific integrin α9β1 inhibits arterial thrombosis in mice2020

    • Author(s)
      Dhanesha N, Nayak MK, Doddapattar P, Jain M, Flora GD, Kon S, Chauhan AK.
    • Journal Title

      Blood

      Volume: 135 Pages: 857-861

    • DOI

      10.1182/blood.2019002846

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07492
  • [Journal Article] Antibodies against nephronectin ameliorate anti‐type II collagen‐induced arthritis in mice2019

    • Author(s)
      Kon S, Honda M, Ishikawa K, Maeda M, Segawa T.
    • Journal Title

      FEBS Open Bio

      Volume: 10 Pages: 107-117

    • DOI

      10.1002/2211-5463.12758

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07492
  • [Journal Article] Role of Nephronectin in Pathophysiology of Silicosis2019

    • Author(s)
      Lee S, Honda M, Yamamoto S, Kumagai-Takei N, Yoshitome K, Nishimura Y, Sada N, Kon S, Otsuki T.
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 20 Pages: 2581-2581

    • DOI

      10.3390/ijms20102581

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07492, KAKENHI-PROJECT-17K09171
  • [Journal Article] The role of α9β1 integrin and its ligands in the development of autoimmune diseases2018

    • Author(s)
      Kon S, Uede T.
    • Journal Title

      Journal of Cell Communication and Signaling

      Volume: 12 Pages: 333-342

    • DOI

      10.1007/s12079-017-0413-7

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K08221
  • [Journal Article] Lactobacillus helveticus SBT2171 Attenuates Experimental Autoimmune Encephalomyelitis in Mice.2018

    • Author(s)
      Yamashita M, Ukibe K, Matsubara Y, Hosoya T, Sakai F, Kon S, Arima Y, Murakami M, Nakagawa H, Miyazaki T.
    • Journal Title

      Front Microbiol

      Volume: 8 Pages: 2596-2596

    • DOI

      10.3389/fmicb.2017.02596

    • NAID

      120006414007

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K08221
  • [Journal Article] A Novel α9 Integrin Ligand, XCL1/Lymphotactin, Is Involved in the Development of Murine Models of Autoimmune Diseases2017

    • Author(s)
      Matsumoto N, Kon S, Nakatsuru T, Miyashita T, Inui K, Saitoh K, Kitai Y, Muromoto R, Kashiwakura JI, Uede T, Matsuda T.
    • Journal Title

      The Journal of Immunology

      Volume: 199 Pages: 82-90

    • DOI

      10.4049/jimmunol.1601329

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K08221, KAKENHI-PROJECT-17K08263
  • [Journal Article] Anti-IL-17A blocking antibody reduces cyclosporinA-induced relapse in experimental autoimmune encephalomyelitis mice2016

    • Author(s)
      Saitoh K, Kon S, Nakatsuru T, Inui K, Ihara T, Matsumoto N, Kitai Y, Muromoto R, Matsuda T
    • Journal Title

      Biochemistry and Biophysics Reports

      Volume: 8 Pages: 139-45

    • DOI

      10.1016/j.bbrep.2016.08.021

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16K08221
  • [Journal Article] A New STAT3-binding Partner, ARL3, Enhances the Phosphorylation and Nuclear Accumulation of STAT3.2016

    • Author(s)
      Togi S, Muromoto R, Hirashima K, Kitai Y, Okayama T, Ikeda O, Matsumoto N, Kon S, Sekine Y, Oritani K, Matsuda T.
    • Journal Title

      J Biol Chem.

      Volume: 印刷中 Pages: 11161-11171

    • DOI

      10.1074/jbc.m116.724849

    • NAID

      120006219975

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25460056, KAKENHI-PROJECT-26461444, KAKENHI-PROJECT-16K08221
  • [Journal Article] Tyk2 is a therapeutic target for psoriasis-like skin inflammation.2014

    • Author(s)
      Ishizaki M, Muromoto R, Akimoto T, Sekine Y, Kon S, Diwan M, Maeda, H, Togi S, Shimoda K, Oritani K, Matsuda T.
    • Journal Title

      Int Immunol.

      Volume: 26 Pages: 257-267

    • DOI

      10.1093/intimm/dxt062

    • NAID

      120005522324

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590072, KAKENHI-PROJECT-24590773, KAKENHI-PROJECT-25460056
  • [Journal Article] A novel cryptic binding motif, LRSKSRSFQVSDEQY, in the C-terminal fragment of MMP-3/7-cleaved osteopontin as a novel ligand for α9β1 integrin is involved in the anti-type II collagen antibody-induced arthritis.2014

    • Author(s)
      Kon S, Nakayama Y, Matsumoto N, Ito K, Kanayama M, Kimura C, Kouro H, Ashitomi D, Matsuda T, Uede T.
    • Journal Title

      PLoS One.

      Volume: 9

    • DOI

      10.1371/journal.pone.0116210

    • NAID

      120005540287

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24590072
  • [Journal Article] Signal-transducing adaptor protein-2 regulates macrophage migration into inflammatory sites duringd extran sodium sulfate induced colitis.2014

    • Author(s)
      Fujita N, Oritani K, Ichii M, Yokota T, Saitoh N, Okuzaki D, Sekine Y, Kon S, Muromoto R, Saitoh K, Yoshimura A, Matsuda T, Kanakura Y.
    • Journal Title

      Eur J Immunol

      Volume: 44 Pages: 1791-1801

    • DOI

      10.1002/eji.201344239

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24590072, KAKENHI-PROJECT-25460056, KAKENHI-PROJECT-26461412, KAKENHI-PROJECT-26461420, KAKENHI-PROJECT-26461444
  • [Journal Article] Signal-transducing adaptor protein-2 controls the IgE-mediated, mast cell-mediated anaphylactic responses2014

    • Author(s)
      Sekine Y, Nishida K, Yamasaki S, Muromoto R, Kon S, Kashiwakura J, Saitoh K, Togi S, Yoshimura A, Oritani K, Matsuda T
    • Journal Title

      Journal of Immunology

      Volume: 192 Pages: 3488-3495

    • DOI

      10.4049/jimmunol.1300886

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590576, KAKENHI-PROJECT-24590072, KAKENHI-PROJECT-25253071, KAKENHI-PROJECT-25460056
  • [Journal Article] The novel α4B murine α4 integrin protein splicing variant inhibits α4 protein-dependent cell adhesion.2014

    • Author(s)
      Kouro H, Kon S, Matsumoto N, Miyashita T, Kakuchi A, Ashitomi D, Saito K, Nakatsuru T, Togi S, Muromoto R, Matsuda T.
    • Journal Title

      J Biol Chem.

      Volume: 289 Pages: 16389-16398

    • DOI

      10.1074/jbc.m114.553610

    • NAID

      120005611280

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24590072, KAKENHI-PROJECT-25460056
  • [Journal Article] Y14 positively regulates TNF-α-induced NF-κB transcriptional activity via interacting RIP1 and TRADD beyond an exon junction complex protein.2013

    • Author(s)
      Togi S, Shiga K, Kon S, Oritani K, Matsuda T
    • Journal Title

      J Immunol.

      Volume: 191 Pages: 1436-1444

    • DOI

      10.4049/jimmunol.1300501

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591387, KAKENHI-PROJECT-24590072, KAKENHI-PROJECT-25460056
  • [Journal Article] Jun activation domain-binding protein 1 (JAB1) is required for the optimal response to interferons.2013

    • Author(s)
      Muromoto R, Oritani K, Matsuda T
    • Journal Title

      Journal of Biological Chemistry

      Volume: 288 Pages: 30969-30979

    • DOI

      10.1074/jbc.m113.485847

    • NAID

      120005397865

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591387, KAKENHI-PROJECT-24590072, KAKENHI-PROJECT-24590773, KAKENHI-PROJECT-25460056
  • [Journal Article] Signal-transducing adaptor protein-2 modulates Fas-mediated T cell apoptosis by interacting with caspase-82012

    • Author(s)
      Sekine Y, et al
    • Journal Title

      Journal of Immunology

      Volume: 188 Pages: 6194-204

    • DOI

      10.4049/jimmunol.1103467

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591062, KAKENHI-PROJECT-23390015, KAKENHI-PROJECT-23790067, KAKENHI-PROJECT-24590072, KAKENHI-PROJECT-24590773
  • [Journal Article] The role of osteopontin in tendon tissue remodeling after denervation-induced mechanical stress deprivation.2007

    • Author(s)
      N.Mori, T.Majima, N.Iwasaki, S.Kon, K.Miyakawa, C.Kimura, K.Tanaka, DT.Denhardt, S.Rittling, A.Minami, T.Uede
    • Journal Title

      Matrix Biol. 26

      Pages: 42-53

    • NAID

      120000961947

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16209014
  • [Journal Article] Loss of osteopontin perturbs the epithelial-mesenchymal transition in an injured mouse lens epithelium.2007

    • Author(s)
      S.Saika, K.Shirai, O.Yamanaka, KI.Miyazaki, Y.Okada, A.Kitano, KC.Flanders, S.Kon, T.Uede, WW.Kao, SR.Rittling, DT.Denhardt, Y.Ohnishi
    • Journal Title

      Lab Invest. 87

      Pages: 130-138

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16209014
  • [Journal Article] Suppression of the bacterial antigen-specific T cell response and the dendritic cell migration to the lymph nodes by osteopontin.2007

    • Author(s)
      MD.Begum, M.Umemura, S.Kon, A.Yahagi, S.Hamada, K.Oshiro, K.Gotoh, A.Nishizono, T.Uede, G.Matsuzaki
    • Journal Title

      Microbiol Immunol. 51

      Pages: 135-147

    • NAID

      10020282178

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16209014
  • [Journal Article] Osteopontin functionally activates dendritic cells and induces their differentiation towards a Th-1 polarizing phenotype.2005

    • Author(s)
      AC.Renkl, J.Wussler, T.Ahrens, K.Thoma, S.Kon T.Uede, SF.Martin, JC.Simon, JM.Weiss
    • Journal Title

      Blood. 106

      Pages: 946-955

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16209014
  • [Journal Article] High plasma concentrations of osteopontin in patients with interstitial pneumonia.2005

    • Author(s)
      J.Kadota, S.Mizunoe, K.Mito, H.Mukae, S.Yoshioka, K.Kawakami, Y.Koguchi, K.Fukushima, S.Kon, S.Kohno, A.Saito, T.Uede, M.Nasu
    • Journal Title

      Respir Med. 99

      Pages: 111-117

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16209014
  • [Journal Article] Circulating interleukin-18 and osteopontin are useful to evaluate disease activity in patients with tuberculosis.2005

    • Author(s)
      S.Inomata, N.Shijubo, S.Kon, M.Maeda, G.Yamada, N.Sato, S.Abe, T.TUede
    • Journal Title

      Cytokine. 30

      Pages: 203-211

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16209014
  • [Journal Article] Osteopontin affects the persistence of beta-glucan-induced hepatic granuloma formation and tissue injury through two distinct mechanisms.2004

    • Author(s)
      J.Morimoto, M.Inobe, C.Kimura, S.Kon, H.Diao, M.Aoki, T.Miyazaki, DT.Denhardt, S.Rittling, T.Uede
    • Journal Title

      Int Immunol. 16

      Pages: 477-488

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16209014
  • [Journal Article] Role of osteopontin in cardiac fibrosis and remodeling in angiotensin II-induced cardiac hypertrophy.2004

    • Author(s)
      Y.Matsui, N.Jia, H.Okamoto, S.Kon, H.Onozuka, M.Akino, K.Liu, J.Morimoto, SR.Rittling, D.Denhardt, A.Kitabatake, T.Uede
    • Journal Title

      Hypertension. 43

      Pages: 1195-1201

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16209014
  • [Journal Article] Effect of osteopontin alleles on beta-grucan induced granuloma formation in the mouse liver.2004

    • Author(s)
      K.Tanaka.J.Morimoto, S.Kon, C.Kimura, M.Inobe, H.Diao, G.Hirschfeld, J.M.Weiss, T.Uede
    • Journal Title

      Am J Pathol. 164

      Pages: 567-575

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16209014
  • [Journal Article] Functional role of death associated protein 3 (DAP3) in anoikis.2004

    • Author(s)
      T.Miyazaki, M.Shen, D.Fujikura, N.Tosa, S.Kon, T.Uede, JC.Reed
    • Journal Title

      J Biol Chem. 279

      Pages: 44667-44672

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16209014
  • [Journal Article] Osteopontin as a mediator of NKT cell function in T cell-mediated liver diseases.2004

    • Author(s)
      H.Diao, S.Kon, K.Iwabuchi, C.Kimura, J.Morimoto, D.Ito, T.Segawa, M.Maeda, J.Hamuro, T.Nakayama, M.Taniguchi, H.Yagita, L.V.Kaer, K.Onoe, D.Denhardt, S.Rittling, T.Uede
    • Journal Title

      Immunity. 21

      Pages: 539-550

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16209014
  • [Patent] 抗ヒトα9インテグリン抗体とその用途2006

    • Inventor(s)
      金山剛士, 黒滝大翼, 今 重之, 上出利光
    • Industrial Property Rights Holder
      (株)ジーンテクノサイエンス
    • Filing Date
      2006-07-12
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16209014
  • [Patent] 抗α9インテグリン抗体とその用途2006

    • Inventor(s)
      黒滝大翼, 金山剛士, 今 重之, 上出利光
    • Industrial Property Rights Holder
      (株)ジーンテクノサイエンス
    • Filing Date
      2006-01-12
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16209014
  • [Patent] 細胞外マトリックスタンパク質のアミノ酸配列RGDに対する抗体および製法と用途2006

    • Inventor(s)
      今 重之, 木 村 千 恵 美, 上出利光
    • Industrial Property Rights Holder
      (株)ジーンテクノサイエンス
    • Filing Date
      2006-10-26
    • Data Source
      KAKENHI-PROJECT-16209014
  • [Patent] オステオポンチンsiRNA2006

    • Inventor(s)
      齋藤善也, 今 重之, 上出利光
    • Industrial Property Rights Holder
      (株)ジーンテクノサイエンス
    • Filing Date
      2006-12-11
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16209014
  • [Patent] オステオポンチンsiRNA2006

    • Inventor(s)
      齋藤善也, 今 重之, 上出利光
    • Industrial Property Rights Holder
      (株)ジーンテクノサイエンス
    • Filing Date
      2006-12-11
    • Data Source
      KAKENHI-PROJECT-16209014
  • [Patent] 細胞外マトリックスタンパク質のアミノ酸配列RGDに対する抗体および製法と用途2006

    • Inventor(s)
      今 重之, 木村千恵美, 上出利光
    • Industrial Property Rights Holder
      (株)ジーンテクノサイエンス
    • Filing Date
      2006-10-26
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16209014
  • [Patent] 抗α9インテグリン抗体とその用途2006

    • Inventor(s)
      黒滝大翼, 金山剛士, 今 重之, 上出利光
    • Industrial Property Rights Holder
      (株)ジーンテクノサイエンス
    • Filing Date
      2006-01-12
    • Data Source
      KAKENHI-PROJECT-16209014
  • [Patent] 抗ヒトα9インテグリン抗体とその用途2006

    • Inventor(s)
      金山剛士, 黒滝大翼, 今 重之, 上出利光
    • Industrial Property Rights Holder
      (株)ジーンテクノサイエンス
    • Filing Date
      2006-07-12
    • Data Source
      KAKENHI-PROJECT-16209014
  • [Patent] オステオポンチンsiRNA2005

    • Inventor(s)
      齋藤善也, 今 重之, 小松康雄, 上出利光
    • Industrial Property Rights Holder
      生化学工業(株), (株)ジーンテクノサイエンス
    • Filing Date
      2005-04-12
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16209014
  • [Patent] 抗α9インテグリン抗体2005

    • Inventor(s)
      黒滝大翼, 今重之, 上出利光
    • Industrial Property Rights Holder
      (株)ジーンテクノサイエンス
    • Filing Date
      2005-01-13
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16209014
  • [Patent] 免疫担当細胞活性化阻害剤およびその用途2004

    • Inventor(s)
      今 重之, 上出利光, ディオコウエン
    • Industrial Property Rights Holder
      (株)免疫生物研究所, (株)ジーンテクノサイエンス
    • Filing Date
      2004-05-21
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16209014
  • [Patent] 腱・靱帯の劣化予防剤、治療剤2004

    • Inventor(s)
      森 律明, 岩崎倫政, 三浪明男, 今 重之, 上出利光, 前田雅弘
    • Industrial Property Rights Holder
      (株)免疫生物研究所, (株)ジーンテクノサイエンス
    • Filing Date
      2004-11-04
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16209014
  • [Presentation] 珪肺症の病態生理におけるネフロネクチンの役割2020

    • Author(s)
      大槻 剛巳、武井 直子、伊藤 達夫、吉留 敬、西村 泰光、本田 真知子、今 重之、李 順姫
    • Organizer
      第90回日本衛生学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K07492
  • [Presentation] α4インテグリンスプライシングバリアントの結合分子の探索と機能解析2019

    • Author(s)
      山田康平、本田真知子、今 重之
    • Organizer
      第58回日本薬学会中国四国支部学術大会
    • Data Source
      KAKENHI-PROJECT-19K07492
  • [Presentation] セレノプロテインPとの相互作用による細胞外基質ネフロネクチンのグルタチオンペルオキシダーゼ誘導の検討2019

    • Author(s)
      本田真知子、斎藤芳郎、今 重之
    • Organizer
      第58回日本薬学会中国四国支部学術大会
    • Data Source
      KAKENHI-PROJECT-19K07492
  • [Presentation] 新規α4インテグリンスプライシングバリアントを用いた自己免疫疾患治療戦略2019

    • Author(s)
      福永真実、本田真知子、今 重之
    • Organizer
      第58回日本薬学会中国四国支部学術大会
    • Data Source
      KAKENHI-PROJECT-19K07492
  • [Presentation] 新規α4インテグリンスプライシングバリアントの同定とその機能解析2018

    • Author(s)
      川崎 岬、重政 歩美、本田 真知子、今 重之
    • Organizer
      第57回日本薬学会中国四国支部会
    • Data Source
      KAKENHI-PROJECT-16K08221
  • [Presentation] The role of signal-transducing adaptor protein-1 in Concanavalin A-induced hepatitis2018

    • Author(s)
      Takeru Ihara, Kodai Saitoh, Shigeyuki Kon, Junichi Kashiwakura, Ryuta Muromoto, Yuichi Kitai, Tadashi Matsuda
    • Organizer
      第46回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K08221
  • [Presentation] 細胞外基質ネフロネクチンに対するサンドイッチELISAシステムの構築2018

    • Author(s)
      本田真知子、李 順姫、松田正、大槻剛巳、今重之
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PROJECT-16K08221
  • [Presentation] 自己免疫疾患における細胞外基質ネフロネクチンの関与2018

    • Author(s)
      藤岡和征、本田真知子、松田正、今重之
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PROJECT-16K08221
  • [Presentation] 抗オステオポンチン抗体を用いた非アルコール性脂肪肝炎増悪化抑制効果の検討2018

    • Author(s)
      本田 真知子、宮崎 純子、今 重之
    • Organizer
      第57回日本薬学会中国四国支部会
    • Data Source
      KAKENHI-PROJECT-16K08221
  • [Presentation] 新規α4インテグリンスプライシングバリアントは内在性α4インテグリン機能抑制分子である2018

    • Author(s)
      重政歩美、乾恭輔、本田真知子、松田正、今重之
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PROJECT-16K08221
  • [Presentation] 抗β8インテグリン抗体を用いた四塩化炭素誘導肝線維化モデル抑制効果の検討2018

    • Author(s)
      重政 歩美、本田 真知子、今 重之
    • Organizer
      第57回日本薬学会中国四国支部会
    • Data Source
      KAKENHI-PROJECT-16K08221
  • [Presentation] 新たな反応性を有する抗β8インテグリン抗体を用いた肝線維化モデル抑制効果の検討2018

    • Author(s)
      重政 歩美、本田 真知子、今 重之
    • Organizer
      第41回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-16K08221
  • [Presentation] インテグリを介した細胞接着の機能抑制による自己免疫疾患治療戦略2016

    • Author(s)
      今 重之
    • Organizer
      第135回日本薬学会中国四国支部例会
    • Place of Presentation
      福山大学(広島県、福山市)
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K08221
  • [Presentation] Soluble alpha4 integrin splicing variant is a novel endogenous integrin inhibitor2016

    • Author(s)
      Kon S, Inui K, Saitoh K, Matsumoto N, Matsuda T
    • Organizer
      第45回日本免疫学会学術集会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県、宜野湾市)
    • Year and Date
      2016-12-05
    • Data Source
      KAKENHI-PROJECT-16K08221
  • [Presentation] T細胞活性化および免疫応答におけるSTAP-2の機能解析2016

    • Author(s)
      齋藤浩大、今重之、小澤清貴、伊原建、関根勇一、室本竜太、鍛代悠一、吉村昭彦、織谷健司、松田正
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県、横浜市)
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-16K08221
  • [Presentation] XCL1/Lymphotactin, a novel ligand of alpha9 integrin, is involved in the development of autoimmune diseases2016

    • Author(s)
      Matsumoto N, Kon S, Nakatsuru T, Matsuda T
    • Organizer
      第45回日本免疫学会学術集会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県、宜野湾市)
    • Year and Date
      2016-12-05
    • Data Source
      KAKENHI-PROJECT-16K08221
  • [Presentation] 新規α4インテグリンバリアントはα4インテグリンの内在性機能阻害因子である2014

    • Author(s)
      紅露ひとみ、松本尚樹、宮下友恵、中鶴拓也、今重之、松田正
    • Organizer
      第51回日本生化学会北海道支部例会
    • Place of Presentation
      札幌
    • Year and Date
      2014-07-18
    • Data Source
      KAKENHI-PROJECT-24590072
  • [Presentation] Lymphotactinは新規α9インテグリンリガンドである2014

    • Author(s)
      中鶴拓也、松本尚樹、紅露ひとみ、今重之、松田正
    • Organizer
      日本薬学会北海道支部第141回例会
    • Place of Presentation
      札幌
    • Year and Date
      2014-05-24
    • Data Source
      KAKENHI-PROJECT-24590072
  • [Presentation] 新規変異型α4インテグリンの同定と機能解析2014

    • Author(s)
      宮下友惠、紅露ひとみ、松本尚樹、今重之、松田正
    • Organizer
      日本薬学会北海道支部第141回例会
    • Place of Presentation
      札幌
    • Year and Date
      2014-05-24
    • Data Source
      KAKENHI-PROJECT-24590072
  • [Presentation] 細胞内配列の異なる新規変異型α4インテグリンは α4インテグリン依存性細胞接着を抑制する2013

    • Author(s)
      紅露 ひとみ、今 重之、松田 正
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド、兵庫県
    • Data Source
      KAKENHI-PROJECT-24590072
  • [Presentation] Identification of a novel alpha9 integrin ligand, lymphotactin2013

    • Author(s)
      Naoki Matsumoto, Shigeyuki Kon, Tadashi Matsuda
    • Organizer
      第42回日本免疫学会
    • Place of Presentation
      千葉県幕張メッセ、千葉県
    • Data Source
      KAKENHI-PROJECT-24590072
  • [Presentation] 細胞内配列の異なる新規変異型α4インテグリンの機能2013

    • Author(s)
      紅露ひとみ、今重之、松田正
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Data Source
      KAKENHI-PROJECT-24590072
  • [Presentation] A novel secreted alpha4 integrin variant inhibits alpa4 and alpha9 integrin-dependent cell adhesion2013

    • Author(s)
      Shigeyuki Kon and Tadashi Matsuda
    • Organizer
      第42回日本免疫学会
    • Place of Presentation
      千葉県幕張メッセ、千葉県
    • Data Source
      KAKENHI-PROJECT-24590072
  • [Presentation] A novel murine α4 integrin splicing variant is a specific receptor for VCAM-12012

    • Author(s)
      Kon S, Kouro H, Matsuda T
    • Organizer
      The 99th AAI Annual Meeting
    • Place of Presentation
      Hynes Convention Center, Boston, USA
    • Data Source
      KAKENHI-PROJECT-24590072
  • [Presentation] α4インテグリンスプライシングバリアントによるインテグリン機能調節機構の解明と創薬への発展

    • Author(s)
      今 重之, 紅露 ひとみ, 中鶴 拓也, 宮下 友惠, 松本 尚樹, 松田 正
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-25 – 2015-03-28
    • Data Source
      KAKENHI-PROJECT-24590072
  • [Presentation] 新規α9インテグリンリガンドLymphotactinの同定と機能解析

    • Author(s)
      中鶴 拓也, 松本 尚樹, 紅露 ひとみ, 松田 正, 今 重之
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-25 – 2015-03-28
    • Data Source
      KAKENHI-PROJECT-24590072
  • 1.  UEDE Toshimitsu (00160185)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 11 results
  • 2.  MIYAZAKI Tadaaki (60272431)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 3.  KOMATSU Yasuo (30271670)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  KOJIMA Naoshi (30356985)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  ONO Etsurou (00160903)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 6.  YOKOSAKI Yasuyuki (80210607)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  Matsui Yuichiro (20374374)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  丸山 光生 (00212225)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  岩渕 和也 (20184898)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  真島 任史 (30241334)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  岩崎 倫政 (30322803)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  三浪 明男 (20133738)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  松田 正 (20212219)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 14.  室本 竜太 (30455597)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 9 results
  • 15.  関根 勇一 (20396295)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 16.  南保 明日香 (60359487)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  猪部 学 (10312414)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  大塚 榮子 (80028836)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  村上 正晃 (00250514)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  船越 忠直 (10528334)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  YOKOTA Takahumi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 22.  ICHII Michiko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 23.  LEE Suni
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 24.  織谷 健司
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 25.  金倉 譲
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 26.  齊藤 則充
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 27.  西田 圭吾
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 28.  西村 泰光
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 29.  大槻 剛巳
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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