Ninomiya Haruaki 二宮治明

… Alternative Names

NINOMIYA Haruaki 二宮治明

二宮冶明ニノミヤハルアキ

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Researcher Number	80212124
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2015 – 2017: 鳥取大学, 医学部, 教授 2007 – 2010: Tottori University, Faculty of Medicine, Professor 2005 – 2006: Tottori University, Faculty of Medicine, Assistant Professor, 医学部, 助教授 2004: Tottori University, Faculty of Medicine, Associate Professor, 医学部, 助教授 1998 – 2003: 鳥取大学, 医学部, 助教授 1995 – 1997: Faculty of Medicine, Kyoto University Asistant, 医学研究科, 助手 1993 – 1994: 京都大学, 医学部, 助手
Review Section/Research Field	Principal Investigator General pharmacology / General medical chemistry / Pathological medical chemistry / Biological Sciences Except Principal Investigator Biological Sciences / General pharmacology / Circulatory organs internal medicine / Pediatrics / Neurology / Biological Sciences / General medical chemistry
Keywords	Principal Investigator コレステロール / cholesterol / ニーマンピック / Niemann-Pick / ユビキチン / サイトカイン / エンドセリン / 酸化ステロール結合蛋白質 / ORP10 / Niemann-Pick C1 Like1 … More / roteasome / ubiquitin / プロテアゾーム / cytokine / IL-6 / NPC1 / ニーマンピック病 / サイントカイン / apoptosis / melanoma / cancer / receptor / endothelin / がん / カベオラ / 伊東細胞 / 受容体 / コレラ毒素 / アポトーシス / メラノーマ / トランスポート / NPC1-L1 / Rab / アストロサイト / ニーマン・ピック / G蛋白質 / 細胞増殖 … More Except Principal Investigator ニーマン・ピック病C型 / エンドセリン / エンドセリン変換酵素 / エンドセリン受容体 / 神経変性 / endothelin receptor / endothelin / 国際エンドセリン会議 / 国際薬理学連合受容体委員会 / エンドセリン受容体拮抗薬 / コレステロール / 一酸化窒素 / LDL / atrial fibrillation / HSP70 / Kv1.5 / endothelin converting enzyme / STAT / タウオパチー / 非選択的カチオンチャネル / geranyl geranyl acetone / stabilization / Hsp70 / CHIP / 細胞内輸送 / ゴルジ体 / 小胞体 / シャペロン誘導薬 / Kv1.5チャンネル / 熱ショック蛋白 / glia / IL-6 / Toll-like receptor / cholesterol / Niemann-Pick disease C / N-octyl-β-valienamine / Chemical chaperone therapy / Gaucher disease / βグルコシダーゼ / 酵素蛋白質の安定化 / ライソゾーム病 / ニーマンピック病 / ニーマン・ピック病 / 小児 / 遺伝病 / 変異酵素活性化療法 / 分子シャペロン療法 / 分子シャペロン / ゴーシェ病 / リソゾーム / secretase / Cholesterol / Amyloid β protein(Aβ) / Amyloid R protein precursor(APP) / Alzheimer's disease(AD) / アルミニウム / アミロイドβ蛋白(Aβ) / リノール酸 / アミロイドβタンパク (Aβ) / α-セレクターゼ / α-セクレターゼ / アミロイドβタンパク(Aβ) / APP遺伝子 / アルツハイマー病 / SNPs / Na^+ channel blockers / ubiquitin-proteasome / ion channel / 小胞体品質管理機構 / 細胞内トラフィック / ユビキチン化 / 蛋白安定化 / Na channel 阻害剤 / ユビキチン・プロテアソーム / 心房細動 / T型Caチャンネル / イオンチャンネル / ペースメーカー活性 / ES細胞 / Endothelin antagonist / Endothelium / IUPHA / Endothelin receptor / Endothelin / エンドセリ / International Conference on Endothelin / International Union of Pharmacological Sciences / Receptor Nomenclature and Drug Classification Committee / endothelin receptor antagonist / cell growth, dystroglycan / vasoconstriction / oxidized LDL / nitric oxide / vascular endothelium / カチオンチャネル / 非選択的陽イオンチャネル / 電位依存性カルシウムチャネル / 変成LDL受容体 / 受容体輸送活性相関 / アルギニン輸送体 / 変性LDL受容体 / ジストログリカン / 酸化LDL / 細胞増殖 / 血管収縮 / 血管内皮 / endothelin antagonist / conference on endothelin / international receptor committee / 受容体拮抗薬 / 薬物受容体 / サイトカイン / JAK / DNAマイクロアレイ / 小児期アルツハイマー病 / ガングリオシド / コレラトキシン / 小胞輸送 / 早期エンドソーム / 細胞内脂質輸送 / クローニング / 一酸化窒素合成酵素 / 結合蛋白質 / ビオプテリン / ビッグエンドセリン / 内皮細胞 / 金属プロテアーゼ / 結合実験 / カルシウムチャンネル / パッチクランプ / 細胞内遊離カルシウム濃度 / ドーパミン遊離 / テトラヒドロビオプテリン / カルシウム拮抗薬 / メフェナム酸 / カルシウムインフラックス / カルシウム / G蛋白質 / カルシウムチャネル Less

Role of ORP10 in NPC1L1-dependent cholesterol transportPrincipal Investigator
- Principal Investigator
  
  Ninomiya Haruaki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Tottori University
Cholesterol-dependent regulation of intracellular localization of NPC1-L1Principal Investigator
- Principal Investigator
  
  NINOMIYA Haruaki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Tottori University
Ubiquitination of Niemann-Pick Cl proteinPrincipal Investigator
- Principal Investigator
  
  NINOMIYA Haruaki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tottori University
Mechanism on Hsp70-induced stabilization of ion channel and its application to the treatment for atrial fibrillation
- Principal Investigator
  
  HISATOME Ichiro
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tottori University
ニーマンピック病C型の神経変性機構の解明Principal Investigator
- Principal Investigator
  
  二宮治明
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tottori University
Establishment of new therapeutic strategies for neurogenetic disorders during childhood
- Principal Investigator
  
  OHNO Kousaku
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Tottori University
ニーマン・ピック病C型の神経変性に対する実験的治療
- Principal Investigator
  
  大野耕策
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tottori University
Stabilization of ion channel protein by regulation of proteasome and its application to the individualizing atrial fibrillation.
- Principal Investigator
  
  HISATOME Ichiro
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  National University Corporation Tottori University
Analysis of the relationship between Amyloid β protein and cholesterol in Alzheimer's disease.
- Principal Investigator
  
  URAKAMI Katsuya
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  National University Corporation Tottori University
ニーマン・ピック病C型の神経変性機構の解明
- Principal Investigator
  
  大野耕策
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tottori University
Identification of cytokines secreted by Niemann-Pick cellsPrincipal Investigator
- Principal Investigator
  
  NINOMIYA Haruaki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Tottori University
ニーマン・ピック病C型の神経変性機構の解明
- Principal Investigator
  
  大野耕策
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Tottori University
ニーマン・ピック病C型の神経変性機構の解明
- Principal Investigator
  
  OHNO Kousaku
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Tottori University
Regulation of endothelin receptor expression through cancer cell differentiationPrincipal Investigator
- Principal Investigator
  
  NINOMIYA Haruaki
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Tottori University
Pharmacology
- Principal Investigator
  
  MASAKI Tomoh
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  General pharmacology
- Research Institution
  National Cardiovascular Center Research Institute
Pharmacology of endothelin and endothelin receptor
- Principal Investigator
  
  MASAKI Tomoh
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  KYOTO UNIVERSITY
Study on the regulatory mechanisms of endothelium-dependent vasoconstriction and growth of vascular cells
- Principal Investigator
  
  MASAKI Tomoh
- Project Period (FY)
  1995 – 1998
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  National Cardiovascular Center Research Institute
  Kyoto University
新しい循環調節薬としてのエンドセリン変換酵素抑制薬開発のための研究
- Principal Investigator
  
  真崎知生, 眞崎知生
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Kyoto University
バイオプテリン結合活性をもつ新しい機能蛋白質群のcDNAクローニング
- Principal Investigator
  
  三輪聡一
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Kyoto University
エンドセリンの細胞増殖刺激作用Principal Investigator
- Principal Investigator
  
  二宮治明
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General pharmacology
- Research Institution
  Kyoto University
Pharmacology of endothelin receptor and its agonist/antagonist
- Principal Investigator
  
  MISAKI Tomoh, 真崎知生
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  KYOTO UNIVERSITY
エンドセリン誘発収縮に関与する新しい因子の検索とそのクローニング
- Principal Investigator
  
  真崎知生, MISAKI Tomoh
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  General medical chemistry
- Research Institution
  Kyoto University
テトラヒドロビオプテリン受容体のクローニング及びその機能解析
- Principal Investigator
  
  三輪聡一
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Kyoto University

All 2011 2010 2009 2007 2006 2004

All Journal Article Presentation

[Journal Article] Lysosomal accumulation of Trk protein in brain of GM1-gangliosidosis mouse and its restoration by chemical chaperone.2011
- Author(s)
  Takamura A., Higaki K., Ninomiya H., Takai T., Matsuda J., Iida M., Ohno K., Suzuki Y., Nanba E.
- Journal Title
  
  J.Neurochem. in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590281
[Journal Article] Reciprocal control of hERG stability by Hsp70 and Hsc70 with implication for restoration of LQT2 mutant stability.2011
- Author(s)
  Li P., Ninomiya H., Kurata Y., Kato M., Miake J., Yamamoto Y., Igawa O., Nakai A., Higaki K., Toyoda F., Wu J., Horie M., Matsuura H., Yoshida A., Shirayoshi Y., Hiraoka M., Hisatome I.
- Journal Title
  
  Cir.Res. 108
  
  Pages: 458-468
- NAID
  130002130408
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590281
[Journal Article] Transcriptional activation of the anchoring protein SAP97 by heat shock factor (HSF)-1 stabilizes K(v) 1.5 channels in HL-1 cells.2011
- Author(s)
  Ting Y., Morikawa K., Kurata Y., Li P., Bahrudin U., Mizuta E., Kato M., Miake J., Yamamoto Y., Yoshida A., Murata M., Inoue T., Nakai A., Shiota G, Higaki K., Nanba E., Ninomiya H., Shirayoshi Y., Hisatome I.
- Journal Title
  
  Br.J.Pharmacol. in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590281
[Journal Article] Chemical chaperone therapy : chaperone effect on mutant enzyme and cellular pathophysiology in β-galactosidase deficiency.2011
- Author(s)
  Higaki K., Li L., Bahrudin U., Okuzawa S., Takamura A., Yamamoto K., Adachi K., Paraguison R.C., Takai T., Ikehata H., Tominaga L., Hisatome I., Iida M., Ogawa S., Matsuda J., Ninomiya H., Sakakibara Y., Ohno K., Suzuki Y., Nanba E.
- Journal Title
  
  Human Mut. in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590281
[Journal Article] Copper incorporation into ceruloplasmin is regulated by Niemann-Pick C1 protein.2011
- Author(s)
  Yanagimoto C., Harada M., Kumemura H., Abe M., Koga H., Sakata M., Kawaguchi T., Terada K., Hanada S., Taniguchi E., Ninomiya H., Ueno T., Sugiyama T., Sata M.
- Journal Title
  
  Hepatol Res. 41
  
  Pages: 484-491
- NAID
  10031144114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590281
[Journal Article] The effect of N-octyl-β-valienamine on β-glucosidase activity in tissues of normal mice.2010
- Author(s)
  Luan Z., Ninomiya H., Ohno K., Ogawa S., Kubo T., Iida M., Suzuki Y.
- Journal Title
  
  Brain Dev. 32
  
  Pages: 805-809
- NAID
  10029559648
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590281
[Journal Article] Chemical chaperone therapy : luciferase assay for screening of β-galactosidase mutations.2010
- Author(s)
  Li L., Higaki K., Ninomiya H., Luan Z., Iida M., Ogawa S., Suzuki Y., Ohno K., Nanba E.
- Journal Title
  
  Mol.Genet.Metab. 101
  
  Pages: 364-369
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590281
[Journal Article] A fluorescent sp^2-iminosugar with pharmacological chaperone activity for Gaucher disease : synthesis and intracellular distribution studies.2010
- Author(s)
  Luan Z., Higaki K., Aguilar-Moncayo M., Li L., Ninomiya H., Nanba E., Ohno K., Garcia-Moreno M.I., Ortiz M.C., Garcia Fernandez J.M., Suzuki Y.
- Journal Title
  
  Chembiochem. 11
  
  Pages: 2453-2464
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590281
[Journal Article] Effect of losartan and benzbromarone on the level of human urate transporter 1 mRNA.2010
- Author(s)
  Nindita Y., Hamada T., Bahrudin U., Hosoyamada M., Ichida K., Iwai C., Urashima S., Kuwabara N., Utami S.B., Mizuta E., Yamada K., Igawa O., Shigemasa C., Ninomiya H., Tsuchihashi T., Hisatome I.
- Journal Title
  
  Arzneimittelforschung 60
  
  Pages: 186-188
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590281
[Journal Article] Different distribution of Cav3.2 and Cav3.1 transcripts encoding T-type Ca(2+) channels in the embryonic heart of mice.2010
- Author(s)
  Mizuta E., Shirai M., Arakawa K., Hidaka K., Miake J., Ninomiya H., Kato M., Shigemasa C., Shirayoshi Y., Hisatome I., Morisaki T.
- Journal Title
  
  Biomed.Res. 31
  
  Pages: 301-305
- NAID
  130004903809
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590281
[Journal Article] Effects of a low-dose antihypertensive diuretic in combination with losartan, telmisartan, or candesartan on serum urate levels in hypertensive patients.2010
- Author(s)
  Hamada T., Mizuta E., Kondo T., Hirai M., Yamada K., Kato M., Shigemasa C., Yamamoto Y., Ninomiya H., Igawa O., Hisatome I.
- Journal Title
  
  Arzneimittelforschung 60
  
  Pages: 71-75
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590281
[Journal Article] The pharmacological chaperone effect of N-octyl-β-valienamine on human mutant acid β-glucosidases.2010
- Author(s)
  Luan Z., Li L., Ninomiya H., Ohno K., Ogawa S., Kubo T., Iida M., Suzuki Y.
- Journal Title
  
  Blood Cells Mol.Diseases 44
  
  Pages: 48-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590281
[Journal Article] Chaperone activity of bicyclic nojirimycin analogues for Gaucher mutations in comparison with N-(n-nonyl)deoxynojirimycin.2009
- Author(s)
  Luan Z., Higaki K., Aguilar-Moncayo M., Ninomiya H., Ohno K., Garcia-Moreno M.I., Ortiz M.C., Garcia Fernandez J.M., Suzuki Y.
- Journal Title
  
  Chembiochem. 23
  
  Pages: 2780-2792
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590281
[Journal Article] Niemann-Pick C1 protein transports copper to the secretory compartment from late endosomes where ATP7B resides.2009
- Author(s)
  Yanagimoto C., Harada M., Kumemura H., Koga H., Kawaguchi T., Terada K., Hanada S., Taniguchi E., Koizumi Y., Koyota S., Ninomiya H., Ueno T., Sugiyama T., Sata M.
- Journal Title
  
  Exp.Cell Res. 315
  
  Pages: 119-126
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590281
[Journal Article] Endosomal accumulation of Toll-like receptor 4 causes constitutive secretion of cytokines and activation of STATs in Niemann-Pick disease type C fibroblasts : a potential basis for glial cell activation in the NPC brain.2007
- Author(s)
  Suzuki M, Sugimoto Y, Ohsaki Y, Ueno M, Kato S, Kitamura Y, Hosokawa H, Davies JP, Ioannou YA, Vanier MT, Ohno K, Ninomiya H.
- Journal Title
  
  J Neurosci 27
  
  Pages: 1879-1891
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390302
[Journal Article] Enzyme enhancement activity of N-octyl-beta-valienamine on beta-glucosidase mutants associated with Gaucher disease.2007
- Author(s)
  Lei K, Ninomiya H, Suzuki M, Inoue T, Sawa M, Iida M, Ida H, Eto Y, Ogawa S, Ohno K, Suzuki Y
- Journal Title
  
  Biochim Biophys Acta 1772
  
  Pages: 587-596
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390302
[Journal Article] Enzyme enhancement activity of N-octyl-beta-valienamine on beta-glucosidase mutants associated with Gaucher disease.2007
- Author(s)
  Lei K, Ninomiya H, Suzuki M, Inoue T, Sawa M, Iida M, Ida H, Eto Y, Ogawa S, Ohno K, Suzuki Y.
- Journal Title
  
  Biochim Biophys Acta. 1772
  
  Pages: 587-96
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390302
[Journal Article] Endosomal accumulation of Toll-like receptor 4 causes constitutive secretion of cytokines and activation of STATs in Niemann-Pick disease type C fibroblasts : a potential basis for glial cell activation in the NPC brain. 27 : 1879-1891,20072007
- Author(s)
  Suzuki M, Sugimoto Y, Ohsaki Y, Ueno M, Kato S, Kitamura Y, Hosokawa H, Davies JP, Ioannou YA, Vanier MT, Ohno K, Ninomiya H
- Journal Title
  
  Journal of Neuroscience 27
  
  Pages: 1879-1891
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390302
[Journal Article] Cholesterol depletion facilitates ubiquitylation of NPC1 and its association with SKD1/Vps4.2006
- Author(s)
  Ohsaki Y, Sugimoto Y, Suzuki M, Hosokawa H, Yoshimori T, Davies JP, Ioannou YA, Vanier MT, Ohno K, Ninomiya H
- Journal Title
  
  J Cell Sci 119
  
  Pages: 2643-2653
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390302
[Journal Article] Cholesterol depletion facilitates ubiquitylation of NPC1 and its association with SKD1/Vps4.2006
- Author(s)
  Ohsaki Y, Sugimoto Y, Suzuki M, Hosokawa H, Yoshimori T, Davies JP, Ioannou YA, Vanier MT, Ohno K, Ninomiya H.
- Journal Title
  
  J Cell Sci. 119
  
  Pages: 2643-2653
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390302
[Journal Article] Axonal dystrophy of dorsal root ganglion sensory neurons in a mouse model of Niemann-Pick disease type C.Experimental2004
- Author(s)
  Ohara S, Ukita Y, Ninomiya H, Ohno K
- Journal Title
  
  Experimental Neurology 187
  
  Pages: 289-298
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390302
[Journal Article] N-Octyl-β-valienamine up-regulates activity of F213I mutant β-glucosidase in cultured cells : a potential chemical chaperone therapy for Gaucher disease2004
- Author(s)
  Lin H, Sugimoto Y, Ohsaki Y, Ninomiya H, Oka A, et al.
- Journal Title
  
  Biochim Biophys Acta 1689
  
  Pages: 219-228
- Data Source
  KAKENHI-PROJECT-16390302
[Journal Article] N-Octyl-β-valienamine up-regulates activity of F213I mutant β-glucosidase in cultured cells : a potential chemical chaperone therapy for Gaucher disease.2004
- Author(s)
  Lin H, Sugimoto Y, Ohsaki Y, Ninomiya H, Oka A, Taniguchi M, Ida H, Eto Y, Ogawa S, Matsuzaki Y, Sawa M, Inoue T, Higaki K, Nanba E, Ohno K, Suzuki Y.
- Journal Title
  
  Biochim Biophys Acta. 1689
  
  Pages: 219-228
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390302
[Journal Article] Increased NPC1 mRNA in skin fibroblasts from Niemann-Pick disease type C patients.2004
- Author(s)
  Yamamoto T, Feng J-H, Higaki K, Taniguchi M, Nanba E, Ninomiya H, Ohno K.
- Journal Title
  
  Brain Dev. 26
  
  Pages: 245-250
- NAID
  10020552645
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390302
[Journal Article] Novel TSC2 mutations and decreased expression of tuberin in cultured tumor cells with an insertion mutation2004
- Author(s)
  Feng J-H, Yamamoto T, Nanba E, Ninomiya H. Oka A. Ohno K
- Journal Title
  
  HUMAN MUTATION #696(Online)
- Data Source
  KAKENHI-PROJECT-16390302
[Journal Article] Axonal dystrophy of dorsal root ganglion sensory neurons in a mouse model of Niemann-Pick disease type C.2004
- Author(s)
  Ohara S, Ukita Y, Ninomiya H, Ohno K.
- Journal Title
  
  Experimental Neurology. 187
  
  Pages: 289-298
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390302
[Journal Article] Increased NPC1 mRNA in skin fibroblasts from Niemann-Pick disease type C patients2004
- Author(s)
  Yamamoto T, Feng J-H, Higaki K, Taniguchi M, Nanba E. Ninomiya H, Ohno K
- Journal Title
  
  Brain Dev 26
  
  Pages: 245-250
- NAID
  10020552645
- Data Source
  KAKENHI-PROJECT-16390302
[Journal Article] Degeneration of cholecystokinin-immunoreactive afferents to the VPL thalamus in a mouse model of Niemann-Pick disease type C.2004
- Author(s)
  Ohara S, Ukita Y, Ninomiya H, Ohno K.
- Journal Title
  
  Brain Research 1022
  
  Pages: 244-246
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390302
[Journal Article] Reduced sensitivity of Niemann-Pick C1-deficient cells to θ-toxin (perfringolysin O) : sequestration of toxin to raft-enriched membrane vesicles.2004
- Author(s)
  Ohsaki Y, Sugimoto Y, Kaidoh T, Shimada Y, Ohno-Iwashita Y, Joanna P. Davies, Yiannis A. Ioannou, Ohno K, Ninomiya H
- Journal Title
  
  Histochem Cell Biol 121
  
  Pages: 263-272
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390302
[Journal Article] Degeneration of cholecystokinin-immunoreactive afferents to the VPL thalamus in mouse model of Niemann-Pick disease type C2004
- Author(s)
  Ohara S, Ukita Y, Ninomiya H, Ohno K
- Journal Title
  
  Brain Research 1022
  
  Pages: 244-246
- Data Source
  KAKENHI-PROJECT-16390302
[Journal Article] Axonal dystrophy of dorsal root ganglion sensory neurons in a mouse model of Niemann-Pick disease type C2004
- Author(s)
  Ohara S, Ukita Y, Ninomiya H, Ohno K
- Journal Title
  
  Experimental Neurology 187
  
  Pages: 289-298
- Data Source
  KAKENHI-PROJECT-16390302
[Journal Article] N-Octyl-β-valienamine up-regulates activity of F213I mutant β-glucosidase in cultured cells : a potential chemical chaperone therapy for Gaucher disease.2004
- Author(s)
  Lin H, Sugimoto Y, Ohsaki Y, Ninomiya H, Oka A, Taniguchi M, Ida H, Eto Y, Ogawa S, Matsuzaki Y, Sawa M, Inoue T, Higaki K, Nanba E, Ohno K, Suzuki Y
- Journal Title
  
  Biochim Biophys Acta 1689
  
  Pages: 219-228
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390302
[Journal Article] Degeneration of cholecystokinin- immunoreactive afferents to the VPL thalamus in a mouse model of Niemann-Pick disease type C.2004
- Author(s)
  Ohara S, Ukita Y, Ninomiya H, Ohno K
- Journal Title
  
  Brain Research 1022
  
  Pages: 244-246
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390302
[Journal Article] Reduced sensitivity of Niemann-Pick C1-deficient cells to θ-toxin (perfringolysin O) : sequestration of toxin to raft-enriched membrane vesicles.2004
- Author(s)
  Ohsaki Y, Sugimoto Y, Kaidoh T, Shimada Y, Ohno-Iwashita Y, Joanna P.Davies, Yiannis A.Ioannou, Ohno K, Ninomiya H.
- Journal Title
  
  Histochem Cell Biol. 121
  
  Pages: 263-272
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390302
[Journal Article] Increased NPC1 mRNA in skin fibroblasts from Niemann-Pick disease type C patients.2004
- Author(s)
  Yamamoto T, Feng J-H, Higaki K, Taniguchi M, Nanba E, Ninomiya H, Ohno K
- Journal Title
  
  Brain Dev 26
  
  Pages: 245-250
- NAID
  10020552645
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390302
[Presentation] Proteasomal degradation of NPC12007
- Author(s)
  Ninomiya, H
- Organizer
  Annual Scientific Conference on NPC
- Place of Presentation
  Tucson, U.S.A
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590295
[Presentation] Proteasomal degradation of NPCl.2007
- Author(s)
  Ninomiya H.
- Organizer
  Annual Scientific Conference on NPC
- Place of Presentation
  Tucson, U.S.A.
- Year and Date
  2007-06-07
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590295
[Presentation] Proteasomal degradation of NPC1.2007
- Author(s)
  Ninomiya H.
- Organizer
  Annual Scientific Conference on NPC
- Place of Presentation
  Tucson, U. S. A.
- Year and Date
  2007-06-07
- Data Source
  KAKENHI-PROJECT-18590295

1. MAWA Soichi (40157706)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
2. MISAKI Tomoh (60009991)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
3. SAWAMURA Tatsuya (30243033)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
4. OHNO Kousaku (70112109)

# of Collaborated Projects: 7 results

# of Collaborated Products: 20 results
5. VANHOUTTE P.

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. VANE J.

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. 真崎知生

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. OKAMOTO Yasuo (80293877)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. HISATOME Ichiro (60211504)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 越村邦夫 (90192575)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 岡明 (00251273)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. HIGAKI Katumi (90294321)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. IGAWA Osamu (80252857)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. TANIGUCHI Sinn-ici (30304207)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. KURATA Yasutaka (00267725)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. MORISAKI Takayuki (30174410)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. URAKAMI Katsuya (30213507)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. TANIGUCHI Miyako (50335527)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. NAKASHIMA Kenji (70144673)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. WAKUTANI Yousuke (10322215)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. INOUE Takehiko (80346361)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
22. HOSHIKAWA Yoshiko (10181489)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. MIAKE Junichiro (40372677)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. Nakasone Naoe (30632947)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 比企一晃 (30263099)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. VANE John

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 桧垣克美

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results

Ninomiya Haruaki 二宮 治明

NINOMIYA Haruaki 二宮 治明

二宮 冶明 ニノミヤ ハルアキ

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Role of ORP10 in NPC1L1-dependent cholesterol transportPrincipal Investigator

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Cholesterol-dependent regulation of intracellular localization of NPC1-L1Principal Investigator

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Ubiquitination of Niemann-Pick Cl proteinPrincipal Investigator

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ニーマンピック病C型の神経変性機構の解明Principal Investigator

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Identification of cytokines secreted by Niemann-Pick cellsPrincipal Investigator

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Regulation of endothelin receptor expression through cancer cell differentiationPrincipal Investigator

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Ninomiya Haruaki 二宮治明

NINOMIYA Haruaki 二宮治明

二宮冶明ニノミヤハルアキ