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KOBAYASHI Masanobu  小林 正伸

ORCIDConnect your ORCID iD *help
Researcher Number 80241321
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2008 – 2014: 北海道医療大学, 看護福祉学部, 教授
2008: 北海道医療大学, 教授
2008: 北海道医療大学, 看護福祉学研究科, 教授
2007: 北海道大学, 遺伝子病制御c研究所, 准教授
2007: Hokkaido University, Inst. Gen. Med, Associate Professor … More
2006: 北海道大学, 大学院歯学研究科, 助教授
1999 – 2006: Hokkaido Univ., Inst Gen.Med.Associate Prof., 遺伝子病制御研究所, 助教授
2005: 北海道大学, 遺伝子制御研究所, 助教授
2005: Hokkaido Univ., Genetic Medicine, Asso.Prof., 遺伝子病制御病研究所, 助教授
2003: Institute for Genetic Medicine, Associate Professor, 遺伝子病制御研究所, 教授
1999: Hokkaido Univ., Inst Gen Med.Associate Prof.
1999: 北海道大学, 医学部, 助教授
1999: 北海道大学, 医学部・附属癌研究施設, 助教授
1998: 北海道大学, 医学部附属癌研究施設, 助教授
1995: Hokkaidto University School of Medicine, Lab. of Pathol, Cancer Inst. Associate Professor, 医学部, 助教授
1993 – 1994: 北海道大学, 医学部, 講師 Less
Review Section/Research Field
Principal Investigator
Pathobiological dentistry/Dental radiology / Biological Sciences / Gastroenterology / Gastroenterology / General surgery / Hematology / Experimental pathology
Except Principal Investigator
Surgical dentistry / Surgical dentistry / Biological Sciences … More / Morphological basic dentistry / Gastroenterology / General surgery / General surgery / Hematology / Thoracic surgery / 病態科学系歯学(含放射線系歯学) / Biological pharmacy / Radiation science Less
Keywords
Principal Investigator
低酸素 / 血管新生 / アポトーシス / adrenomedullin / HIF-1 / 膵癌 / アドレノメジュリン / Pim-1 / hypoxia / HIF-1alpha … More / vHL / Granulocytic sarcoma / TIMP / 低栄養 / 腫瘍増殖 / AMF / pim-1 / in vivo growth / resistance to anticancer drugs / apoptosis / PIM-1 / 癌遺伝子 / 膵がん / 生体内増殖 / 抗癌剤耐性 / glycolysis / adrenomedullin antagonist / angiogenesis / pancreatic cancer / Glucose transporter / hypoglycemia / Hypoxin / 解糖系酵素 / 転移 / 適応応答 / dominant negative HIF-1α / gene therapy / genetic analysis / Pancreatic Cancer / VHL / 遺伝子治療 / HIF-1α / 遺伝子解析 / Motility / Collagenase / Leukemia / コラーゲン分解酵素 / マトリゲル / 炎症性サイトカイン / 遊走能 / コラゲナーゼ / 髄外腫瘤 / 白血病 / 低栄養環境 / IRF3 / IFN-beta / SIRT1 / PIAS3 / 低酸素環境 / 脱アセチル化酵素 / 転写因子 / 口腔癌 / セリンスレオニンカイネース / アドレノメジュリン阻害 / 遺伝子発現 / 血管新生阻害剤 / MMP-9 / Hypoxia / 低癌剤耐性 / c-kit / CD49d / CD34陽性細胞 / ヒト骨髄造血前駆細胞 / 接着因子 / 白血病細胞株 / 伸展 / ファイブロネクチン … More
Except Principal Investigator
E1AF / HIF-1 / 口腔扁平上皮がん / p53 / E4orf6 / Oral carcinoma / 口腔がん / DNA microarray / アポトーシス / 低酸素 / Adrenomedullin / 遺伝子治療 / アデノウイルスベクター / HuR / Pim-1 / 膵癌 / 血管新生 / マクロファージ / サイトカイン / c-myc / c-fos / ARE-mRNA / アドレノメデュリン / リンパ節転移 / CRM1 / 発癌 / Hypoxia / DNAマイクロアレイ / 転移 / RhoC / signal transduction / TNF-α / apoptosis / NF-κB / MyD88 / Taxol / Bnip3 / adenoviral vector / caveolin-1 / p21 / HGF / Ad12E1A / 抗癌剤耐性 / 癌遺伝子 / 遺伝子導入 / エンドトキシンショック / MIF / antiangiogenic therapy / endothelial cell / tumor angiogenesis / 遺伝子標的治療 / 腫瘍血管内皮 / 血管新生阻害療法 / 血管内皮細胞 / 腫瘍血管新生 / adrenomedullin / cell-specific gene transfer / nanocoloid / ナノテクノロジー / EGFレセプター / 細胞特異的遺伝子導入 / ナノコロイド / human lung carcinoma / human ranal carcinoma / human oral carcinoma / tumor endothelial cell / ヒト口腔癌 / 網羅的解析 / ヒト肺癌 / ヒト腎癌 / ヒトロ腔癌 / 腫瘍血管内皮細胞 / Stabilization / Nuclear Export / Adenovirus / 安定化 / 核外輸送 / アデノウイルス / Genetic alteration / Chemotherapy / Radiation therapy / Oral Cancer / 治療効果予測因子 / 遺伝子変異 / 化学療法併用 / 放射線治療 / Gene targeting therapy / 腫瘍血管 / Carcinogenesis / Bcl-2 family / Chemo- and radio- sensitivity / real-time RT-PCR / Bcl-2 / VEGF-C / Bc1-2 / 術前感受性 / tumor progression / carcinogenesis / free radicals / ischemia-reperfusion / 低酸素インキュベーター / 低酸素環境 / 悪性化進展 / フリーラジカル / 低酸素再酸素化 / Pancreatic Cancer / ドミナント・ネガティブ / 低酸素適応 / metastasis / DNAマクロアレイ / ets oncogene / Gene therapy / Protein-protein interaction / Invasion and metastasis / Immortalization / 浸潤 / TIMP / MMP / Etsがん遺伝子 / タンパク相互作用 / 浸潤転移 / 細胞不死化 / gene therapy / pancreatic cancer / 抑制変異体 / 遺伝子 / pim-1 / toll-like receptor / taxol / シグナル伝達 / TNF-a / Transmembrane domain / Apoptosis / 膜貫通ドメイン / geneterapy / lung cancer / SCCA promoter / 遺伝子解析 / 癌化 / 肺AAH / 肺癌 / SCCAプロモーター / promoter activity / adenvirus vector / 転写調節領域 / survivin / プロモーター活性 / cell cycle regulation / 細胞周期調節 / 細胞周期 / 転写調節 / アデノウィルスベクター / E1AFプロモーター / ウイルスベクター / RNAサブトラクション法 / yeast two hybrid / ets がん遺伝子 / EIAF / 結合タンパク / etsがん遺伝子群転写因子 / DNAチップ / 癌抑制遺伝子 / SIRT7 / HIF-1 / CHMP5 / MDM2 / 脱アセチル化酵素 / SIRT7 / 低グルコース応答 / 低酸素応答 / 炎症発癌 / 浸出制御 / 炎症細胞 / ARE mRNA / 核細胞質移行 / 悪性化因子 / 口腔白板症 / 遣伝子発現 / 遺伝子発現 / 転移形質 / p56ファミリー / p53ファミリー / 腫瘍再発 / 増殖抑制 / 低栄養 / 抗癌剤感受性 / 低グルコース / 増殖 / BCL6 / 低栄養環境 / 低酸素適応応答 / FGF / タンパク安定化 / FGFシグナリング / 骨誘導 / ポリリン酸 / ets / GnT-V / 糖転移酵素 / 転写機構 / ETS がん遺伝子 / E1AD / 転写因子相互作用 / ETSがん遺伝子 / 合成ペプチド / 発現プラスミド / カーボンナノファイバー / glucose metabolism / tumor / deoxyglucose / emission tomography / 癌浸潤 / 培養ヒト癌細胞 / Th1型のサイトカイン / bleomycin / ラット肝細胞癌 / TGF-β / 抗腫瘍免疫応答性 / 低用量癌化学療法 / 癌化学療法 / LAK-attractant / 腫瘍組織 / LAK細胞 / 養子免疫療法 Less
  • Research Projects

    (46 results)
  • Research Products

    (36 results)
  • Co-Researchers

    (39 People)
  •  Regulation of adaptive responses to hypoxia and glucose deprivation by NAD-dependent deacetylase SIRT7

    • Principal Investigator
      NAKAGAWA KOJI
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Hokkaido University
  •  The roles of HDAC and transcription factors in oral cancer developmentPrincipal Investigator

    • Principal Investigator
      KOBAYASHI Masanobu
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathobiological dentistry/Dental radiology
    • Research Institution
      Health Sciences University of Hokkaido
  •  Establishment of optimal anti-angiogenic therapy against cancer of oral cavityPrincipal Investigator

    • Principal Investigator
      KOBAYASHI Masanobu
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathobiological dentistry/Dental radiology
    • Research Institution
      Health Sciences University of Hokkaido
  •  炎症発癌を標的とした阻害性低分子化合物の探索

    • Principal Investigator
      岡田 太
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Yamagata University
  •  Elucidation of the roles of an oncogene BCL6 in the adaptation response to hypoxia and its application to the therapy for esophageal cancer

    • Principal Investigator
      SHIMIZU Yuichi
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Hokkaido University
  •  Roles of p53 family proteins on the risk-factor of recurrence in oral squamous cell carcinomas.

    • Principal Investigator
      ISHIKAWA Makoto
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      Hokkaido University
  •  Detection of cervical lymphnode micrometastasis in oral cancer

    • Principal Investigator
      ONO Mitsunobu
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      Hokkaido University
  •  口腔白板症の悪性化に関わる因子は何か?-HuRと細胞質移行タンパクの解析-

    • Principal Investigator
      進藤 正信
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Surgical dentistry
    • Research Institution
      Hokkaido University
  •  顎骨骨折・顎骨欠損への再生医療の試み-ポリリン酸による顎骨誘導-

    • Principal Investigator
      松沢 祐介
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Surgical dentistry
    • Research Institution
      Hokkaido University
  •  Export and stabilization of AU-rich element containng mRNA in oral cancer cells

    • Principal Investigator
      HIGASHINO Fumihro
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Hokkaido University
  •  Gene Targeting Therapy against tumor endothelial cells

    • Principal Investigator
      TOTSUKA Yasunori
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Hokkaido University
  •  Development of gene delivery system using nanocoloid and its application for gene targeting therapy

    • Principal Investigator
      SHINDOH Masanobu
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Hokkaido University
  •  Analysis of Tumor-associated Endothelial Cell Biology

    • Principal Investigator
      HIDA Kyoko
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      Hokkaido University
  •  転写因子相互作用による口腔がんの悪性形質獲得機構の解析

    • Principal Investigator
      進藤 正信
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Surgical dentistry
    • Research Institution
      Hokkaido University
  •  口腔がんの発症・進展におよぼす糖転移酵素GnT-Vの影響

    • Principal Investigator
      戸塚 靖則
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Surgical dentistry
    • Research Institution
      Hokkaido University
  •  Roles of Pim-1 oncogene in oral squamous cell carcinoma.

    • Principal Investigator
      ISHIKAWA Makoto
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      Hokkaido University
  •  An exploitation of gene targeting therapy against hypoxic condition of oral carcinoma.

    • Principal Investigator
      ONO Mitsunobu
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      Hokkaido University
  •  Evaluation of pre-operative Chemoradiotherapy in Oral Squamous Cell Carcinoma. -Integration of molecular biology and clinical state-

    • Principal Investigator
      OHIRO Yoichi
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      Hokkaido University
  •  血管新生阻害因子アドレノメジュリンアンタゴニストによる膵癌の分子標的遺伝子治療Principal Investigator

    • Principal Investigator
      小林 正伸
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  Elucidation of the roles of Pim-1 induced under hypoxia in pancreatic cancer and its application to the cancer therapyPrincipal Investigator

    • Principal Investigator
      KOBAYASHI Masanobu
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Hokkaido University
  •  Gene targeting therapy for oral carcinoma using adrenomedullin antagonisit.

    • Principal Investigator
      SHINDOH Masanobu
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Hokkaido University
  •  Translation research for predicting the prognosis of oral malignant tumors.

    • Principal Investigator
      TOTSUKA Yasunori
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Hokkaido University
  •  カーボンナノチューブによる細胞・組織へのデリバリーシステムの構築

    • Principal Investigator
      TOTSUKA Yasunori
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Surgical dentistry
    • Research Institution
      Hokkaido University
  •  Molecular Targeted Therapy with Dominant Negative HIF-1 for Pancreatic Cancer

    • Principal Investigator
      KOBAYASHI Takahiko
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  Roles of Free Radicals Produced under Hypoxic Condition on the Tumor Development and Progression

    • Principal Investigator
      OKADA Futoshi
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General surgery
    • Research Institution
      YAMAGATA UNIVERSITY
      Hokkaido University
  •  低酸素誘導転写因子(HIF-1)による低酸素適応応答を制御する薬剤の探索Principal Investigator

    • Principal Investigator
      小林 正伸
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Experimental pathology
    • Research Institution
      Hokkaido University
  •  FDG-PET検査の改良による腫瘍の鑑別診断法の開発:膜輸送遺伝子・酵素学的検討

    • Principal Investigator
      玉木 長良
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Radiation science
    • Research Institution
      Hokkaido University
  •  Development of therapy for pancreatic cancers which targets adaptation response to hypoxia.Principal Investigator

    • Principal Investigator
      KOBAYASHI Masanobu
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Hokkaido University
  •  Research on factors involved in prognosis of oral carcinoma.

    • Principal Investigator
      SHINDOH Masanobu
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  Identification of HIF-1a target genes and their biological roles in oral carcinoma.

    • Principal Investigator
      ONO Mitsunobu
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      Hokkaido University
  •  癌細胞浸潤及び血管新生におけるマクロファージ遊走阻止因子の機能に関する基礎的研究

    • Principal Investigator
      西平 順
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  低酸素誘導転写因子HIF-1αを標的分子とする膵癌治療法の開発Principal Investigator

    • Principal Investigator
      小林 正伸
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  Development of cancer specific vector for lung carcinoma by inducing RCAS1 ligand and SCCA promoter

    • Principal Investigator
      MORIKAWA Toshiaki
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Thoracic surgery
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  Induction of apoptosis in oral squamous cell carcinoma by activating caspase

    • Principal Investigator
      TOTSUKA Yasunori
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Hokkaido University
  •  Relationship of Drug Sensitivity and Expression of hypoxia-inducible factor-1 (HIF-1)

    • Principal Investigator
      HASHINO Satoshi
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  Identification of mechanism of the metastasis via RhoC signal cascade and development of therapeutic gene for pancreatic cancer

    • Principal Investigator
      KAJI Mitsuhito
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  癌細胞浸潤及び血管新生におけるマクロファージ遊走阻止因子の機能に関する基礎的研究

    • Principal Investigator
      西平 順
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  The role of E1AF, an ets-oncogene family tranascription factor in cell cycle regulation.

    • Principal Investigator
      TOTSUKA Yasunori
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Hokkaido University
  •  Development of gene therapy by using suppressor oncogene vHL for pancreatic cancerPrincipal Investigator

    • Principal Investigator
      KOBAYASHI Masanobu
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  Gene therapy for oral squamous cell carcinoma targeting tumor specific promoter activation

    • Principal Investigator
      SHINDOH Masanobu
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      病態科学系歯学(含放射線系歯学)
    • Research Institution
      Hokkaido University
  •  TGF-β産生抑制と宿主免疫増強を目的とした低用量癌化学療法の開発

    • Principal Investigator
      細川 真澄男
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Hokkaido University
  •  An atempt of gene therapy for oral squamous cell carcinoma

    • Principal Investigator
      SHINDOH Masanobu
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Morphological basic dentistry
    • Research Institution
      Hokkaido University
  •  Identification of targetgenes of E1AF using two hybrid system

    • Principal Investigator
      SHINDO Masanobu
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Morphological basic dentistry
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  造血幹細胞の増殖・分化に与える接着因子の役割の検討Principal Investigator

    • Principal Investigator
      小林 正伸
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University
  •  Mechanisms for the formation of granulocytic sarcoma in leukemiaPrincipal Investigator

    • Principal Investigator
      KOBAYASHI Masanobu
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Hokkaidto University School of Medicine
  •  LAK細胞の癌組織集積性を増強するサイトカインの精製とその遺伝子の同定

    • Principal Investigator
      細川 真澄男
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Hokkaido University

All 2013 2012 2011 2010 2009 2007 2006 2005 2004 2003

All Journal Article Presentation

  • [Journal Article] Hypoxia-Inducible Factors Activate CD133 Promoter through ETS Family Transcription Factors.2013

    • Author(s)
      Ohnishi S, Maehara O, Nakagawa K, Kameya A, Otaki K, Fujita H, Higashi R, Takagi K, Asaka M, Sakamoto N, Kobayashi M, Takeda H.
    • Journal Title

      Plos One

      Volume: 20

    • NAID

      120005326763

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592839
  • [Journal Article] Hypoxia-inducible Factors Activate CD133 Promoter through ETS Family Transcription Factors2013

    • Author(s)
      Ohnishi S, Maehara O, Nakagawa K, Kameya A, Otaki K, Fujita H, Higashi R, Takagi K, Asaka M, Sakamoto N, Kobayashi M, Takeda H
    • Journal Title

      Plos One

      Volume: 8 Issue: 6 Pages: e66255-e66255

    • DOI

      10.1371/journal.pone.0066255

    • NAID

      120005326763

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390185, KAKENHI-PROJECT-24590074, KAKENHI-PROJECT-24659359
  • [Journal Article] Enhancement of in vitro cell motility and invasiveness of human malignant pleural mesothelioma cells through the HIF-1α-MUC1 pathway.2013

    • Author(s)
      Goudarzi H, Iizasa H, Furuhashi M, Nakazawa S, Nakane R, Liang S, Hida Y, Yanagihara K, Kubo T, Nakagawa K, Kobayashi M, Irimura T, Hamada J.
    • Journal Title

      Cancer Lett

      Volume: 339 Issue: 1 Pages: 82-91

    • DOI

      10.1016/j.canlet.2013.07.020

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590443, KAKENHI-PROJECT-23590451, KAKENHI-PROJECT-24590074
  • [Journal Article] Enhancement of in vitro cell motility and invasiveness of human malignant pleural mesothelioma cells through the HIF-1α-MUC1 pathway.2013

    • Author(s)
      Goudarzi H, Iizasa H, Furuhashi M, Nakazawa S, Nakane R, Liang S, Hida Y, Yanagihara K, Kubo T, Nakagawa K, Kobayashi M, Irimura T, Hamada J.
    • Journal Title

      Cancer Lett.

      Volume: 339 Pages: 82-92

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592839
  • [Journal Article] P53 transactivation is involved in the antiproliferative activity of the putative tumor suppressor RBM52012

    • Author(s)
      Kobayashi T, et al
    • Journal Title

      Int J Cancer

      Volume: 128 Pages: 304-318

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592397
  • [Journal Article] The nuclear protein Artemis promotes AMPK activation by stabilizing the LKB1-AMPK complex2012

    • Author(s)
      Nakagawa K, Uehata Y, Natsuizaka M, Kohara T, Darmanin S, Asaka M, Takeda H, Kobayashi M.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 427 Issue: 4 Pages: 790-795

    • DOI

      10.1016/j.bbrc.2012.09.140

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590074, KAKENHI-PROJECT-24592839
  • [Journal Article] P53 transactivation is involved in the antiproliferative activity of the putativetumor suppressor RBM52011

    • Author(s)
      Kobayashi T, Ishida J, Musashi M, Ota S, Yoshida T, Shimizu Y, Chuma M, Kawakami Asaka M, Tanaka J, Imamura M, Kobayashi M, H, Itoh H, Edamatsu H, Sutherland LC, Brachmann RK.
    • Journal Title

      Int J Cancer

      Volume: 128 Pages: 304-318

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592397
  • [Journal Article] Adrenomedullin antagonist suppresses in renal cell carcinoma through inhibitory effects on tumor endothelial cells and endothelial progenitor mobilization2010

    • Author(s)
      Tsuchiya K, Hida K, Hida Y, Muraki C, Ohga N, Akino T, Kondo T, Miseki T, Nakagawa K, Shindoh M, Harabayashi T, Shinohara N, Nonomura K, Kobayashi M.
    • Journal Title

      Int J Oncol

      Volume: 36 Pages: 1379-86

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592397
  • [Journal Article] p53 transactivation is involved in the antiproliferative activity of the putative tumor suppressor RBM5.2010

    • Author(s)
      Kobayashi T, et al.
    • Journal Title

      Int J Cancer

      Volume: (EPUB 電子書籍)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592397
  • [Journal Article] Pim-1 plays a pivotal role in hypoxia-induced chemoresistance2009

    • Author(s)
      Chen J, Kobayashi M, Darmanin S, Qiao Y, Gully C, Zhao R, Yeung SC, Lee MH.
    • Journal Title

      Oncogene

      Volume: 28 Pages: 2581-92

    • Data Source
      KAKENHI-PROJECT-21592397
  • [Journal Article] Hypoxia-Mediated Up-Regulation of Pim-1 Contributes to Solid Tumor Formation2009

    • Author(s)
      Chen J, Kobayashi M, Darmanin S, Qiao Y, Gully C, Zhao R, Kondo S, Wang H, Wang H, S-C Yeung S-C and Lee M-H.
    • Journal Title

      Am J Pathol

      Volume: 175 Pages: 400-11

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592397
  • [Journal Article] Pim-1 activation of cel motility induces the malignant phenotype of tongue carcinoma2009

    • Author(s)
      Tanaka S, Kitamura T, Higashino F, Hida K, Ohiro Y, Ono M, Kobayashi M, Totuska Y, Shindoh M
    • Journal Title

      Mol Med Rep (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592333
  • [Journal Article] Nano-Scaled Particles of Titanium Dioxide Convert Benign Mouse Fibrosarcoma Cells into Aggressive Tumor Cells2009

    • Author(s)
      Onuma K, Sato Y, Ogawara S, Shirasawa N, Kobayashi M, Yoshitake J, Yoshimura T, Iigo M, Fujii J and Okada F.
    • Journal Title

      Am J Pathol

      Volume: 175 Pages: 2171-2183

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21592397
  • [Journal Article] Suppression of tumor growth by intra-muscular transfer of naked DNA encoding adrenomedullin antagonist.2007

    • Author(s)
      Miseki T, Shindo M, Kobayashi M, et al.
    • Journal Title

      Cancer Gene Therapy 14

      Pages: 39-44

    • Data Source
      KAKENHI-PROJECT-17592061
  • [Journal Article] Enhanced expression of asparagine synthetase under glucose-deprived conditions protects pancreatic cancer cells from apoptosis induced by glucose deprivation and cisplatin2007

    • Author(s)
      Cui H, Darmanin S, Natsuisaka M, Kondo T, Asaka M, Shindoh M, Higashino F, Hamuro J, Okada F, Kobayashi M, Nakagawa K, Koide H, Kobayashi M
    • Journal Title

      Cancer Res. 67

      Pages: 3346-3355

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590707
  • [Journal Article] Suppression of tumor growth by intra-muscular transfer of naked DNA encoding adrenomedullin antagonist.2007

    • Author(s)
      Miseki T, Kawakami H, Natsuizaka M, Demanin S, Cui HY, Chen J, Fu Q, Okada F, Shindo M, Higashino F, Asaka M, Hamuro J, Kobayashi M
    • Journal Title

      Cancer Gene Therapy 14

      Pages: 39-44

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17592061
  • [Journal Article] Elevated oxidative stress in erythrocytes due to a SOD1 deficiency causes anaemia and triggers autoantibody production2007

    • Author(s)
      Iuchi Y, Okada F, Onuma K, Onoda T, Asao H, Kobayashi M, Fujii J.
    • Journal Title

      Biochem J. 402

      Pages: 219-27

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590707
  • [Journal Article] Suppression of tumor growth by intra-muscular transfer of naked DNA encoding adrenomedullin antagonist2007

    • Author(s)
      Miseki T, Kawakami H, Natsuizaka M, Darmanin S, Cui H-Y, Chen J, Fu Q, Okada F, Shindo M, Higashino F, Asaka M, Hamuro J, and Kobayashi M
    • Journal Title

      Cancer Gene Ther. 14

      Pages: 39-44

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590707
  • [Journal Article] Suppression of tumor growth by intra-muscular transfer of naked DNA encoding adrenomedullin antagonist.2007

    • Author(s)
      Miseki T, Kawakami H, Natsuizaka M, Demanin S, Cui H Y, Chen J, Fu Q, Okada F, Shindoh M, Higashino F, Asaka M, Hamuro J, Kobayashi M
    • Journal Title

      Cancer Gene Ther 14

      Pages: 39-44

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390531
  • [Journal Article] Synergistic up-regulation of Hexokinase 2, glucose transporters and angiogenic factors in pancreatic cancer cells by glucose-deprivation and hypoxia2007

    • Author(s)
      Natsuizaka M, Ozasa M, Darmanin S, Miyamoto M, Kondo S, Kamada S, Shindoh M, Higashino F, Suhara W, Koide H, Aita K, Nakagawa K, Kondo T, Asaka M, Okada F, Kobayashi M.
    • Journal Title

      Exp. Cell Res. 313

      Pages: 3337-48

    • NAID

      120000971111

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590707
  • [Journal Article] All-trans retinoic acid enhances murine dendritic cell migration to draining lymph nodes via the balance of matrix metalloproteinases and their inhibitors2007

    • Author(s)
      Darmanin S, Chen J, Zhao S, Cui H, Shirkoohi R, Kubo N, Kuge Y, Tamaki N, Nakagawa K, Hamada J, Moriuti T, Kobayashi M.
    • Journal Title

      J of Immunol 179

      Pages: 4616-4625

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590707
  • [Journal Article] Suppression of tumor growth by intra-muscular transfer of naked DNA encoding adrenomedullin antagonist.2007

    • Author(s)
      Miseki T, Shindo M, Kobayashi M et al.
    • Journal Title

      Cancer Gene Therapy 14

      Pages: 39-44

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17592061
  • [Journal Article] Cross- regulation of VEGF and Angiopoietin-like4 under hypoxia.2006

    • Author(s)
      Kamata S, Matsuizaka M, Nakagawa K, Ohiro Y, Shindoh M, Higashino F, Koide F, Kobayashi M, Totsuka Y
    • Journal Title

      Hokkaido Journal of Dental Science 27

      Pages: 96-103

    • NAID

      10018675950

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17592062
  • [Journal Article] Overexpression of the oncoprotein prothymosin alpha triggers a p53 response that involves p53 acetylation.2006

    • Author(s)
      Kobayashi T., Wang T., Maezawa M., Kobayashi M., Ohnishi S., Hatanaka K., Hige H., Shimizu Y., Kato M., Asaka M, Tanaka J., Imamura M., Hasegawa K., Tanaka Y., Brachmann RK.
    • Journal Title

      Cancer Res. 66

      Pages: 3137-3144

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390222
  • [Journal Article] Overexpression of the Oncoprotein Prothymosin {alpha} Triggers a p53 Response that Involves p53 Acetylation.2006

    • Author(s)
      Kobayashi T.
    • Journal Title

      Cancer Res. 66・6

      Pages: 3137-3144

    • Data Source
      KAKENHI-PROJECT-15390222
  • [Journal Article] Suppression of tumor growth by intra-muscular transfer of naked DNA encoding adrenomedullin antagonisit.2006

    • Author(s)
      Miseki T, Shindo M, Higashino F, Kobayashi M et al.
    • Journal Title

      Cancer Gene Therapy In press

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390575
  • [Journal Article] Overexpression of the Oncoprotein Prothymosin alpha Triggers a p53 Resnonse that Involves p53 Acetvlation2006

    • Author(s)
      Kobayashi T.
    • Journal Title

      Cancer Res. 66

      Pages: 3137-3144

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390222
  • [Journal Article] Suppression of tumor growth by intra-muscular transfer of naked DNA encoding adrenomedullin antagonisit.2006

    • Author(s)
      Miseki T, Shindo M, Higashino F, Kobayashi M et al.
    • Journal Title

      Cancer Gene Therapy 13(in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390575
  • [Journal Article] Adenovirus E4orf6 targets pp32/LAMP to export AU-rich element containing mRNAs by perturbing CRM1-dependent mechanism.2005

    • Author(s)
      Higashino F, Kobayashi M, Totsuka Y, Shindoh M et al.
    • Journal Title

      J cell Biol 170

      Pages: 15-20

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390575
  • [Journal Article] Adenovirus E4orf6 targets pp32/LAMP to export AU-rich element containing mRNAs by perturbing CRM1-dependent mechanism.2005

    • Author(s)
      Higashino F, Kobayashi M, Totsuka Y, Shindoh M et al.
    • Journal Title

      J Cell Biol 170

      Pages: 15-20

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390575
  • [Journal Article] Acetylcholine from vagal stimulation protects cardiomyocytes against ischemia and hypoxia involving additive non hypoxic induction of HIF-1alpha.2005

    • Author(s)
      Kakinuma Y, Ando M, Kuwabara M, Katare RG, Okudela K, Kobayashi M, Sato T.
    • Journal Title

      FEBS Lett. 579

      Pages: 2111-2118

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390222
  • [Journal Article] Hypoxia suppresses the production of matrix metalloproteinases and the migration of humanmonocyte-derived dendritic cells.2005

    • Author(s)
      Zhao W, Darmanin S, Fu Q, Chen J, Cui H, Wang J, Okada F, Hamada JI, Hattori YI, Kondo T, Hamuro J, Asaka M, Kobayashi M.
    • Journal Title

      Eur J Immunol. 35

      Pages: 3468-3477

    • NAID

      120000956474

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390222
  • [Journal Article] Hypoxia induces adhesion molecules on cancer cells : A missing link between Warburg effect and induction of selectin-ligand carbohydrates.2004

    • Author(s)
      Koike T, Kimura N, Miyazaki K, Yabuta T, Kumamoto K, Takenoshita S, Chen J, Kobayashi M, Hosokawa M, Taniguchi A, Kojima T, Ishida N, Kawakita M, Yamamoto H, Takematsu H, Suzuki A, Kozutsumi Y, Kanangi R
    • Journal Title

      Proc.Natl.Acad.Sci.USA 101

      Pages: 8132-8137

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390222
  • [Journal Article] Adrenomedullin antagonist suppresses in vivo growth of human pancreatic cancer cells in SCID mice by suppressing angiogenesis.2003

    • Author(s)
      Ishikawa T, Chen J, Wang J, Okada F, Sugiyama T, Kobayashi T, Shindo M, Higashino F, Katoh H, Asaka M, Kondo T, Hosokawa M, Kobayashi M
    • Journal Title

      Oncogene 22

      Pages: 1238-1242

    • NAID

      120000955159

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390222
  • [Journal Article] Dominant negative HIF-1a reduces tumorigenicity of pancreatic cancer cells through the suppression of hypoxia-inducible anaerobic metabolism.2003

    • Author(s)
      Chen J, Kobayashi M, Akakura N, Zhao S, Nakada K, Kuge Y, Tamaki N, Wang J, Shindo M, Higashino F, Seth P, Hosokawa M
    • Journal Title

      Am J Pathol. 162

      Pages: 1283-1291

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390222
  • [Presentation] The effect of cyclooxygenase-2 inhibitor on tumor-associated endothelial cells.2006

    • Author(s)
      Muraki C, Hida K, Hida Y, Shih SC, Tsuchiya K, Kobayashi M, Klagsbrun M, Shindoh M
    • Organizer
      65^<th> Annual Meeting of Japanese Cancer Association
    • Place of Presentation
      Yokohama (Pacifico Yokohama)
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390530
  • 1.  SHINDOH Masanobu (20162802)
    # of Collaborated Projects: 26 results
    # of Collaborated Products: 11 results
  • 2.  HIGASHINO Fumihiro (50301891)
    # of Collaborated Projects: 22 results
    # of Collaborated Products: 7 results
  • 3.  TOTSUKA Yasunori (00109456)
    # of Collaborated Projects: 17 results
    # of Collaborated Products: 2 results
  • 4.  OHIRO Yoichi (40301915)
    # of Collaborated Projects: 13 results
    # of Collaborated Products: 2 results
  • 5.  HIDA Kyoko (40399952)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 2 results
  • 6.  YASUDA Motoaki (90239765)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 7.  KITAMURA Tetsuya (00451451)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 1 results
  • 8.  ONO Mitsunobu (50281829)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 1 results
  • 9.  細川 真澄男 (20001901)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 10.  OKADA Futoshi (00250423)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 11.  KOBAYASHI Takahiko (80333607)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 8 results
  • 12.  KATOH Hiroyuki (80002369)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 13.  TODO Satoru (60136463)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  FUGETSU Bunshi (40281844)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 15.  ISHIKAWA Makoto (10202970)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 16.  TADA Mitsuhiro (10241316)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 17.  KONDO Satoshi (30215454)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 18.  西平 順 (30189302)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 19.  小山 芳一 (90186841)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 20.  岩渕 和也 (20184898)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 21.  陳 健
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 22.  SHIMIZU Yuichi (90333608)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  NAGAYASU Hiroki (90265075)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  NAKAGAWA KOJI (80360949)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 25.  YOSHIDA Koichi (60117653)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  MORIKAWA Toshiaki (60292025)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  TEI Kanchu (80180066)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  HASHINO Satoshi (60271665)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  KAJI Mitsuhito (40322812)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  HIDA Yasuhiro (30399919)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  今村 雅寛 (20160062)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  玉木 長良 (30171888)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  小華和 征志 (90234806)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 34.  久下 裕司 (70321958)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 35.  松沢 祐介 (30351620)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 36.  澤田 幸治 (80111128)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 37.  ONE Keisin
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 38.  坂本 直哉
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 39.  飯笹 久
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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