HIRAI Masashi 平井完史

Researcher Number	80312578
Affiliation (based on the past Project Information) *help	2004: 東北大学, 大学病院, 助手 2003 – 2004: 東北大学, 病院・助手 2002 – 2003: Tohoku University Hospital, Department of Diabetes and Metabolism, Research Associate, 医学部附属病院, 助手 2002: 東北大学, 医学部付属病院, 助手 2002: 東北大学, 大学院・医学系研究科, 教授 1999 – 2002: 東北大学, 医学部・附属病院, 助手
Review Section/Research Field	Principal Investigator Metabolomics Except Principal Investigator Metabolomics / Metabolomics / Biological Sciences
Keywords	Principal Investigator インスリン抵抗性 / inositol glycan / insulin resistance / impairment of insulin secretion / GPI specific phospholipase D / Type 2 diabetes mellitus / イノシトールグリカン / インスリン分泌不全 / GPI特異的フォスフォリパーゼD / 2型糖尿病 … More / プロテインフォスファターゼ / 遺伝子解析 / プロテインフォスファターゼ2Cα / 糖尿病 … More Except Principal Investigator 糖尿病 / Diabetes / HNF / インスリン / インスリン受容体基質1 / インスリン受容体 / インスリン抵抗性 / シアリダーゼ / ガングリオシド / type 2 diabetes / 2型糖尿病 / PDK1 / PKC / acyl-coenzyme A dehydrogenase / GLUT4 / GC-MS / 酸化ストレス / Wolfram syndrome / Insulin / endoplasmic reticulum / インスリン分泌 / 小胞体ストレス / ノックアウトマウス / WFS1 / ウオルフラム症候群 / 膵β細胞 / MODY / 分子生物学 / インスリン非依存性糖尿病 / oxidative stress / transcription factor / フォークヘッドファミリー / 若年発症糖尿病 / 転写因子 / insulin receptor substrate 1 / insulin receptor / insulin resistance / glucose tolerance / adenovirus vector / sialidase / ganglioside / diabetes / 耐糖能 / アデノウイルスベクター / Insulin receptor substrate 1 / Insulin receptor / Knockout mice / Transgenic mice / Insulin resistance / Sialidase / Ganglioside / タンスジェニックマウス / トラスジェニックマウス / intracellular signaling / glucose transport / インスリン反応性アミノペプチダーゼ / acy1-CoA dehdrogenase / GFP / シグナル伝達 / 糖輸送 / cell cycle / Endoplasmic reticulum stress / pancreatic B cell / Insulin secretion / glutamate / PPARa / GLUD1 / GDH / GPLD1 / ウェルナー症候群 / SNP / 細胞周期 / 8-oxo-deoxyguanosine / Oxidative DNA damage / Oxidative stress / Diabetic retinopathy / Diabetic nephropathy / Diabetic complication / Diabetes mellitus / 活性酸素 / DNA損傷 / 8-OXO-deoxyguanosine / 8-oxo-deoxyguanosive / 酸化的DNA損傷 / 糖尿病性網膜症 / 糖尿病性腎症 / 糖尿病合併症 / knock-out mice / pancreatic β cell / 視神経萎縮 / ER(endoplasmic reticulum) / アポトーシス / 小胞体 / gene mutations / ガングリオシド抗体 / 膵ラ島β細胞 / DNA / Chimeric RNA / 一塩基置換修復法 / ミトコンドリアDNA / ミトコンドリア Less

膵ラ島β細胞ミトコンドリアを標的とする遺伝子治療の開発
- Principal Investigator
  
  SUZUKI Susumu
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Metabolomics
- Research Institution
  Tohoku University
Elucidation of abnormality of plasma membrane microdomain in type 2 diabetes mellitus
- Principal Investigator
  
  SUZUKI Susumu
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  Tohoku University
The role of genes of forkhead transcription factors in type2 diabetes and obesity.
- Principal Investigator
  
  HINOKIO Yoshinori
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Tohoku University
The role of plasma membrane type sialidase gene Neu3 on the pathogenesis of type 2 diabetes mellitusin Japanese.
- Principal Investigator
  
  SUZUKI Susumu
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  Tohoku University
The role of phospholipase D in the development of diabetes mellitusPrincipal Investigator
- Principal Investigator
  
  HIRAI Masashi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  TOHOKU UNIVERSITY
Elucidation of diabetes-related genes
- Principal Investigator
  
  OKA Yoshitomo
- Project Period (FY)
  2001 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
Studies on mechanisms of insulin-stimulated glucose transport : analysis of downstream signaling and real-time monitoring of GLUT4 translocation
- Principal Investigator
  
  OKA Yoshitomo
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  Tohoku University
The cascade of hepatocyte nuclear factor in early-onset diabetes.
- Principal Investigator
  
  HINOKIO Yoshinori
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Tohoku University
糖尿病・インスリン抵抗性におけるプロテインフォスファターゼ2Cαの役割の解明Principal Investigator
- Principal Investigator
  
  平井完史
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Metabolomics
- Research Institution
  Tohoku University
Generation of Wolfram syndrome mice, aiming at development of new therapeutics for diabetes through preserving pancreatic beta cells
- Principal Investigator
  
  OKA Yoshitomo
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Metabolomics
- Research Institution
  Tohoku University
  Yamaguchi University
Development of a new assay method for oxidative DNA damages in diabetes
- Principal Investigator
  
  SUZUKI Susumu
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Tohoku University
The HNF-related transcription cascade in maturity-onset diabetes of the young.
- Principal Investigator
  
  HINOKIO Yoshinori
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Tohoku University

All 2005 2004

All Journal Article

[Journal Article] WRN gene 1367 Arg allele protects against development of type 2 diabetes mellitus.2005
- Author(s)
  Hirai M, Suzuki S, Hinokio Y, Yamada T, Yoshizumi S, Suzuki C, Satoh J, Oka Y.
- Journal Title
  
  Diabetes Res Clin Pract 69
  
  Pages: 287-292
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590862
[Journal Article] WRN gene 1367 Arg allele protects against development of type 2 diabetes mellitus2005
- Author(s)
  Hirai M, Suzuki S, Hinokio Y, et al.
- Journal Title
  
  Diabetes Res Clin Pract. 69
  
  Pages: 287-292
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13204062
[Journal Article] Secondary sulfonylurea failure : comparison of period until insulin treatment between diabetic patients treated with gliclazide and glibenclamide.2005
- Author(s)
  Satoh J, Takahashi K, Takizawa Y, Ishihara H, Hirai M, Katagiri H, Hinokio Y, Suzuki S, Tsuji I, Oka Y.
- Journal Title
  
  Diabetes Res Clin Pract 70
  
  Pages: 291-297
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590862
[Journal Article] WRN gene 1367 Arg allele protects against development of type 2 diabetes mellitus.2005
- Author(s)
  Hirai M, Suzuki S, Hinokio Y, Yamada T, et al.
- Journal Title
  
  Diabetes Res Clin Pract. 69・3
  
  Pages: 287-292
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390259
[Journal Article] Secondary sulfonylurea failure : comparison of period until insulin treatment between diabetic patients treated with gliclazide and glibenclamide.2005
- Author(s)
  Satoh J, Takahashi K, Takizawa Y, Ishihara H, Hirai M, Katagiri H, Hinokio Y, Suzuki S, Tsuji I, Oka Y.
- Journal Title
  
  Diabetes Res Clin Pract. 70
  
  Pages: 291-297
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590862
[Journal Article] WRN gene 1367 Arg allele protects against development of type 2 diabetes mellitus.2005
- Author(s)
  Hirai M, Suzuki S, Hinokio Y, Yamada T, et al.
- Journal Title
  
  Diabetes Res Clin Pract 69・3
  
  Pages: 287-92
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390259
[Journal Article] WRN gene 1367 Arg allele protects against development of type 2 diabetes mellitus.2005
- Author(s)
  Hirai M, Suzuki S, Hinokio Y, et al.
- Journal Title
  
  Diabetes Res Clin Pract 69・3
  
  Pages: 287-292
- Data Source
  KAKENHI-PROJECT-16659236
[Journal Article] WRN gene 1367 Arg allele protects against development of type 2 diabetes mellitus.2005
- Author(s)
  Hirai M, Suzuki S, Hinokio Y, Yamada T, Yoshizumi S, Suzuki C, Satoh J, Oka Y.
- Journal Title
  
  Diabetes Res Clin Pract. 69
  
  Pages: 287-292
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590862
[Journal Article] Genetic variations at urotensin II and urotensin II receptor genes and risk of type 2 diabetes mellitus in Japanese.2004
- Author(s)
  Suzuki S, Zong Wenyi, Hirai M, Hinokio Y, Suzuki C, Yamada T, Yoshizumi S, Suzuki M, Tanizawa Y, Matsunami A, Oka Y.
- Journal Title
  
  Peptides 25
  
  Pages: 1803-1808
- Data Source
  KAKENHI-PROJECT-13204062
[Journal Article] Genetic Variations at Urotensin II and Urotensin II Receptor Genes and Risk of Type 2 Diabetes Mellitus in Japanese.2004
- Author(s)
  Suzuki S, Wenyi Z, Hirai M, Hinokio Y, Suzuki C, et al.
- Journal Title
  
  Peptide 25
  
  Pages: 1801-1808
- Data Source
  KAKENHI-PROJECT-16390259
[Journal Article] Premoter polymorphism of SLC11A1 (formerly NRAMP1) confers susceptibility to autoimmune type 1 diabetes mellitus in Japanese.2004
- Author(s)
  Takahashi K, Satoh J, Kojima Y, Negoro K, Hirai M, Hinokio Y, Kinouchi Y, Suzuki S, Matsuura N, Shimosegawa T, Oka Y
- Journal Title
  
  Tissue Antigens 63
  
  Pages: 231-236
- Data Source
  KAKENHI-PROJECT-16590862
[Journal Article] Genetic Variations at Urotensin II and Urotensin II Receptor Genes and Risk of Type 2 Diabetes Mellitus in Japanese.2004
- Author(s)
  Suzuki S, Wenyi Z, Hirai M, Hinokio Y, Suzuki C, et al.
- Journal Title
  
  Peptide 25
  
  Pages: 1801-1808
- Data Source
  KAKENHI-PROJECT-16659236
[Journal Article] Genetic variations at urotensin II and urotensin II receptor genes and risk of type 2 diabetes mellitus in Japanese.2004
- Author(s)
  Suzuki S, Zong Wenyi, Hirai M, Hinokio Y, Suzuki C, Yamada T, Yoshizumi S, Suzuki M, Tanizawa Y, Matsunami A, Oka Y
- Journal Title
  
  Peptides 25
  
  Pages: 1803-1808
- Data Source
  KAKENHI-PROJECT-16590862

1. HINOKIO Yoshinori (10282071)

# of Collaborated Projects: 11 results

# of Collaborated Products: 13 results
2. SUZUKI Susumu (70216399)

# of Collaborated Projects: 8 results

# of Collaborated Products: 11 results
3. ISHIHARA Hisamitsu (60361086)

# of Collaborated Projects: 7 results

# of Collaborated Products: 2 results
4. KATAGIRI Hedeki (00344664)

# of Collaborated Projects: 7 results

# of Collaborated Products: 2 results
5. OKA Yoshitomo (70175256)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
6. MIYAGI Taeko (50006110)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 谷澤幸生 (00217142)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 湯尻俊昭

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. TAKAHASHI Kazuma (60292215)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 佐々木輝昌

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 竹田孔明

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 松本健

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 谷沢幸生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HIRAI Masashi 平井 完史

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The role of phospholipase D in the development of diabetes mellitusPrincipal Investigator

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糖尿病・インスリン抵抗性におけるプロテインフォスファターゼ2Cαの役割の解明Principal Investigator

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[Journal Article] WRN gene 1367 Arg allele protects against development of type 2 diabetes mellitus.2005

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[Journal Article] WRN gene 1367 Arg allele protects against development of type 2 diabetes mellitus2005

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Description

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[Journal Article] Secondary sulfonylurea failure : comparison of period until insulin treatment between diabetic patients treated with gliclazide and glibenclamide.2005

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HIRAI Masashi 平井完史