Yahiro Kinnosuke 八尋錦之助

… Alternative Names

YAHIRO Kinnosuke 八尋錦之助

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Researcher Number	80345024
Other IDs	https://orcid.org/0000-0002-9813-0780
External Links
Affiliation (Current)	2025: 京都薬科大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2021: 京都薬科大学, 薬学部, 教授 2016 – 2020: 千葉大学, 大学院医学研究院, 准教授 2013 – 2016: 千葉大学, 医学(系)研究科(研究院), 准教授 2010 – 2012: 千葉大学, 大学院・医学研究院, 特任准教授 2002 – 2005: CHIBA UNIVERSITY, GRADUATE SCHOOL OF MEDICINE, ASSISTANT, 大学院・医学研究院, 助手
Review Section/Research Field	Principal Investigator Bacteriology (including mycology) / Bacteriology (including Mycology) / Basic Section 49050:Bacteriology-related Except Principal Investigator Bacteriology (including Mycology) / Bacteriology (including Mycology)
Keywords	Principal Investigator 細胞死 / 細菌毒素 / ADP-リボシル化 / 毒素 / 受容体 / アポトーシス / ADP-リボシル化毒素 / 細菌 / マイクロRNA / Cholix … More / マイクロアレイ / エキソソーム / miRNA / マイクロアレイ解析 / PHB / 腸管出血性大腸菌 / 阻害剤 / 腸管オルガノイド / ドラッグリポジションニング / ER　ストレス / PKC活性化剤 / ステロイド / 小胞体ストレス / ドラッグリポジショニング / 細胞障害 / エフェクター / サイトカイン / 活性酸素 / 走化性 / 好中球 / シグナル伝達 … More Except Principal Investigator 志賀毒素 / 腸管出血性大腸菌 / 毒素 / ADP-ribosylation / Helicobacter pyroli / Polyphenols / Enteroheamorrhagic Eschelicia coli O157 / Vacuolating toxin (VacA) / Vero toxin / Botulinum toxin / Cholera toxin / 無毒化剤 / ボツリヌス菌 / 腸管出血生大腸菌O157 / コレラ菌 / ベロ毒素(VT) / コレラ毒素(CT) / ABサブユニット毒素 / ABサブユニット / レセプター / ADP-リボシル化 / Helicobacter pylori / ポリフェノール / 腸管出血性大腸菌O157 / 空砲化致死毒(VacA) / ベロ毒素 / ボツリヌス毒素 / コレラ毒素 / vaccine / bacterial toxin / toxicity / VacA toxin / vacuolating cytotoxin / Helicobacier pylori / 病原遺伝子群 / ワクチン開発 / CagPAI / VacA / 成分ワクチン / ヘリコバクター・ピロリ / ワクチン / 細菌毒素 / 毒性発現 / VacA毒素 / 空胞化毒素 / ヘリコバクター / cytotoxin / ganglioside GM1-like structure / Ganalioside GM1 / Haemophilus influenza / Guillain-Barre syndrome / ガングリオシドGQ1b / 神経障害 / リポ多糖 / ガングリオシドGM / 抗カングリオシドGM1 / 上気道炎 / 呼吸器感染症 / Haemophilus influenzae / 急性下痢症 / Campylobacter jejuni / ギラン・バレー症候群(GBS) / サイトトキシン / ガングリオシドGMl様構造 / ガングリオシドGMl / Heaemophilus influenzae / ギランバレー症候群 / NO / lipid-raft / 阻害剤 / 取り込み機構 / オートファジー / ｌipid-raft / 酸化ストレス / ストレスグラニュール / 細胞死 / 一酸化窒素 / 小胞体ストレス / SubAB / Bcl-2 / ERストレス / BiP / サブチラーゼサイトトキシン / 受容体 / アポトーシス / ER ストレス Less

Functional analysis of exosome siRNA in Cholix-induced hepatic cell deathPrincipal Investigator
- Principal Investigator
  
  Yahiro Kinnosuke
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  Kyoto Pharmaceutical University
  Chiba University
Mechanism of inhibition of Shiga-toxigenic Escherichia coli SubAB cytotoxicity by steroids and diacylglycerol analoguesPrincipal Investigator
- Principal Investigator
  
  YAHIRO KINNOSUKE
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  Chiba University
Elucidation of the mechanism of Cholix cytotoxicity via its receptor.Principal Investigator
- Principal Investigator
  
  Yahiro Kinnosuke
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  Chiba University
Elucidation of the pathogenic reinforcement action of enterohemorrhagic Escherichia coli produced SubAB
- Principal Investigator
  
  Noda Masatoshi
- Project Period (FY)
  2012 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Chiba University
Analysis of human cell death mechanism caused by ADP-ribosyltransferase Cholix toxinPrincipal Investigator
- Principal Investigator
  
  YAHIRO Kinnosuke
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Chiba University
Elucidation of Shiga-toxigenic Escherichia coli produced Subtilase cytotoxin-induced cell damage mechanism.
- Principal Investigator
  
  NODA Masatoshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Chiba University
H.pylori由来酸性ホスファターゼの宿主応答制御機序の解析Principal Investigator
- Principal Investigator
  
  八尋錦之助
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Chiba University
Development of a quick neutralization therapy for the diseases caused by bacterial toxins
- Principal Investigator
  
  NODA Masatoshi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Chiba University
Development of a quick diagnosis of Haemophilus influenzea Which induces Guillain- Barre syndrome.
- Principal Investigator
  
  NODA Masatoshi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  CHIBA UNIVERSITY
Basic research for H. pylori component vaccine
- Principal Investigator
  
  HITAYAMA Toshiya
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Nagasaki University

[Book] Handbook of Proteolytic Enzymes, 3^<rd> Edition ［Cytotoxin SubAB (Chapter 694)］2013
- Author(s)
  Yahiro, K., J. Moss, and M. Noda
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-24390104
[Journal Article] A novel endoplasmic stress mediator, Kelch domain containing 7B (KLHDC7B), increased Harakiri (HRK) in the SubAB-induced apoptosis signaling pathway2021
- Author(s)
  Yahiro Kinnosuke、Ogura Kohei、Tsutsuki Hiroyasu、Iyoda Sunao、Ohnishi Makoto、Moss Joel
- Journal Title
  
  Cell Death Discovery
  
  Volume: 7 Issue: 1 Pages: 360-360
- DOI
  10.1038/s41420-021-00753-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07534, KAKENHI-PROJECT-20K07506, KAKENHI-PROJECT-21K07002
[Journal Article] Involvement of protein disulfide isomerase in subtilase cytotoxin-induced cell death in HeLa cells2020
- Author(s)
  Tsutsuki Hiroyasu、Zhang Tianli、Harada Ayaka、Rahman Azizur、Ono Katsuhiko、Yahiro Kinnosuke、Niidome Takuro、Sawa Tomohiro
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 525 Issue: 4 Pages: 1068-1073
- DOI
  10.1016/j.bbrc.2020.03.008
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10019, KAKENHI-PROJECT-19K07534, KAKENHI-PROJECT-19K22258
[Journal Article] Host response to the Subtilase cytotoxin produced by locus of enterocyte effacement (LEE)-negative Shiga-toxigenic Escherichia coli (STEC)2020
- Author(s)
  Tsutsuki, H. Ogura, K. Moss, J. Yahiro, K.
- Journal Title
  
  Microbiology and Immunology.
  
  Volume: 64 Issue: 10 Pages: 657-665
- DOI
  10.1111/1348-0421.12841
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07534, KAKENHI-PROJECT-20K08823
[Journal Article] Cell death signaling pathway induced by Cholix toxin, a cytotoxin and eEF2 ADP-ribosyltransferase produced by Vibrio cholerae2020
- Author(s)
  Ogura, K. Yahiro, K. Moss, J.
- Journal Title
  
  Toxins
  
  Volume: 13 Issue: 1 Pages: 12-12
- DOI
  10.3390/toxins13010012
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07534, KAKENHI-PROJECT-18K07133
[Journal Article] Subtilase cytotoxin induces a novel form of Lipocalin 2, which promotes Shiga-toxigenic Escherichia coli survival.2020
- Author(s)
  Yahiro, K., Ogura, K., Goto, Y., Iyoda, S., Kobayashi, T., Takeuchi, H., Ohnishi, M., Moss, J.
- Journal Title
  
  Scientific Reports.
  
  Volume: 10 Issue: 1 Pages: 18943-18943
- DOI
  10.1038/s41598-020-76027-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07534, KAKENHI-PROJECT-20K07506, KAKENHI-PROJECT-19H03465, KAKENHI-PROJECT-18K07133
[Journal Article] Preparation of Biodegradable PLGA-Nanoparticles Used for pH-Sensitive Intracellular Delivery of an Anti-inflammatory Bacterial Toxin to Macrophages2020
- Author(s)
  Harada Ayaka、Tsutsuki Hiroyasu、Zhang Tianli、Lee Ruda、Yahiro Kinnosuke、Sawa Tomohiro、Niidome Takuro
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 68 Issue: 4 Pages: 363-368
- DOI
  10.1248/cpb.c19-00917
- NAID
  130007824942
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2020-04-01
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22258, KAKENHI-PROJECT-17K10019, KAKENHI-PROJECT-19K07534, KAKENHI-PROJECT-18H02098
[Journal Article] Helicobacter pylori Vacuolating Cytotoxin A Causes Anorexia and Anxiety via Hypothalamic Urocortin 1 in Mice2019
- Author(s)
  Suzuki H, Ataka K, Asakawa A, Cheng KC, Ushikai M, Iwai H, Yagi T, Arai T, Yahiro K, Yamamoto K, Yokoyama Y, Kojima M, Yada T, Hirayama T, Nakamura N, Inui A
- Journal Title
  
  Sci Rep
  
  Volume: 9 Issue: 1 Pages: 6011-6011
- DOI
  10.1038/s41598-019-42163-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07281, KAKENHI-PROJECT-18K09838, KAKENHI-PROJECT-19K07534
[Journal Article] Helicobacter pylori Vacuolating Cytotoxin A Causes Anorexia and Anxiety via 1 Hypothalamic 　　Urocortin 1 in Mice2019
- Author(s)
  H. Suzuki, K. Ataka, A. Asakawa, K, Cheng. M, Ushikai. H. Iwai, T. Arai, K. Yahiro, K. Yamamoto, Y. Yokoyama, M. Kojima, T. Yada, T. Hirayama, N. Nakamura, A. Inu
- Journal Title
  
  Scientific Reports
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08770
[Journal Article] A CRISPR Screen Using Subtilase Cytotoxin Identifies SLC39A9 as a Glycan-Regulating Factor2019
- Author(s)
  Yamaji Toshiyuki、Hanamatsu Hisatoshi、Sekizuka Tsuyoshi、Kuroda Makoto、Iwasaki Norimasa、Ohnishi Makoto、Furukawa Jun-ichi、Yahiro Kinnosuke、Hanada Kentaro
- Journal Title
  
  iScience
  
  Volume: 15 Pages: 407-420
- DOI
  10.1016/j.isci.2019.05.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07357, KAKENHI-PROJECT-19K07534, KAKENHI-ORGANIZER-17H06413, KAKENHI-PLANNED-17H06417
[Journal Article] Cholix toxin, an eEF2 ADP-ribosyltransferase, interacts with Prohibitins and induces apoptosis with mitochondrial dysfunction in human hepatocytes.2019
- Author(s)
  Yahiro K, Ogura K, Terasaki Y, Satoh M, Miyagi S, Terasaki M, Yamasaki E, Moss J.
- Journal Title
  
  Cell Microbiol.
  
  Volume: 4 Issue: 8
- DOI
  10.1111/cmi.13033
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09630, KAKENHI-PROJECT-19K07534, KAKENHI-PROJECT-18K07462
[Journal Article] Mechanism of inhibition of Shiga-toxigenic Escherichia coli SubAB cytotoxicity by steroids and diacylglycerol analogues2018
- Author(s)
  Yahiro Kinnosuke、Nagasawa Sayaka、Ichimura Kimitoshi、Takeuchi Hiroki、Ogura Kohei、Tsutsuki Hiroyasu、Shimizu Takeshi、Iyoda Sunao、Ohnishi Makoto、Iwase Hirotaro、Moss Joel、Noda Masatoshi
- Journal Title
  
  Cell Death Discovery
  
  Volume: 4 Issue: 1 Pages: 22-22
- DOI
  10.1038/s41420-017-0007-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08486, KAKENHI-PROJECT-16K08770, KAKENHI-PROJECT-17K10019, KAKENHI-PROJECT-18K07133, KAKENHI-PROJECT-16K08771
[Journal Article] Vibrio cholerae Cholix toxin-induced HepG2 cell death is enhanced by tumor necrosis factor-alpha through ROS and intracellular signal-regulated kinases2017
- Author(s)
  1.Ogura K, Terasaki Y, Miyoshi-Akiyama T, Terasaki M, Moss J, Noda M, Yahiro K.
- Journal Title
  
  Toxicological Science
  
  Volume: 156 Pages: 455468-455468
- DOI
  10.1093/toxsci/kfx009
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18977, KAKENHI-PROJECT-16K08770, KAKENHI-PROJECT-17K09630
[Journal Article] Nitric oxide-enhanced Shiga toxin production was regulated by Fur and RecA in enterohemorrhagic Escherichia coli O157.2017
- Author(s)
  K. Ichimura, Shimizu. T, Takeuchi. H, Matsumoto. A, Yahiro. K, Noda. M,
- Journal Title
  
  MicrobiologyOpen
  
  Volume: 印刷中 Issue: 4 Pages: 1-17
- DOI
  10.1002/mbo3.461
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390104, KAKENHI-PROJECT-26670208, KAKENHI-PROJECT-16K08771, KAKENHI-PROJECT-16K15315, KAKENHI-PROJECT-16K08770
[Journal Article] Silver nanoparticles as potential antibiofilm agents against human pathogenic bacteria2017
- Author(s)
  Kyaw K, Harada A, Ichimaru H, Kawagoe T, Yahiro K, Morimura S, Ono K, Tsutsuki H, Sawa T, Niidome T.
- Journal Title
  
  Chem Lett
  
  Volume: 46 Issue: 4 Pages: 594-596
- DOI
  10.1246/cl.161198
- NAID
  130005549076
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-15H03115, KAKENHI-PROJECT-15H06509, KAKENHI-PROJECT-16K08770
[Journal Article] Translation from the 5' untranslated region shapes the integrated stress response2016
- Author(s)
  Starck SR, Tsai JC, Chen K, Shodiya M, Wang L, Yahiro K, Martins-Green M, Shastri N, Walter P.
- Journal Title
  
  Science
  
  Volume: 351 Issue: 6272
- DOI
  10.1126/science.aad3867
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390104
[Journal Article] 5‘非翻訳領域からの翻訳が統合的ストレス応答に適応する2016
- Author(s)
  八尋錦之助
- Journal Title
  
  Science: Japanese Scientists in Science 2016
  
  Volume: 19 Pages: 19-19
- Data Source
  KAKENHI-PROJECT-16K08770
[Journal Article] 腸管出血性大腸菌感染症の現状と病原性2016
- Author(s)
  八尋錦之助、野田公俊
- Journal Title
  
  化学療法の領域
  
  Volume: 32 Pages: 70-76
- Data Source
  KAKENHI-PROJECT-24390104
[Journal Article] 腸管出血性大腸菌感染の現状と病原性2016
- Author(s)
  八尋錦之助、野田公俊
- Journal Title
  
  化学療法の領域
  
  Volume: 32（4） Pages: 70-76
- Data Source
  KAKENHI-PROJECT-16K08770
[Journal Article] Subtilase cytotoxin produced by locus of enterocyte effacement-negative Shiga-toxigenic Escherichia coli induces stress granule formation2016
- Author(s)
  H. Tsutsuki, K. Yahiro, K. Ogura, K. Ichimura, S. Iyoda, M. Ohnishi, S. Nagasawa, K. Nagasawa, J. Moss, M. Noda
- Journal Title
  
  Cellular Microbiology
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390104
[Journal Article] DAP1, a Negative Regulator of Autophagy, Controls SubAB-Mediated Apoptosis and Autophagy2014
- Author(s)
  Yahiro, K. Tsutsuki, H. Ogura, K. Nagasawa, S. Moss, J. Noda, M.
- Journal Title
  
  Infect Immun
  
  Volume: 82 Issue: 11 Pages: 4899-4908
- DOI
  10.1128/iai.02213-14
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390104
[Journal Article] Uptake of Shiga-toxigenic Escherichia coli SubAB by HeLa cells requires an actin- and lipid raft-dependent pathway2014
- Author(s)
  Nagasawa, S. Ogura, K. Tsutsuki, H. Saitoh, H. Moss, J. Iwase, H. Noda, M. Yahiro, K.
- Journal Title
  
  Cell Microbiol
  
  Volume: 16 Issue: 10 Pages: 1582-1601
- DOI
  10.1111/cmi.12315
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390104
[Journal Article] 腸管出血性大腸菌の病原性発現機構2012
- Author(s)
  八尋錦之助
- Journal Title
  
  化学療法の領域
  
  Volume: 28 Pages: 45-52
- Data Source
  KAKENHI-PROJECT-24390104
[Journal Article] Regulation of Subtilase cytotoxin (SubAB)-induced cell death by a PKR-like endoplasmic reticulum kinase (PERK)-dependent proteasome pathway in HeLa cells2012
- Author(s)
  Yahiro, K.Tsutsuki, H.Ogura, K.Nagasawa, S.Moss, J.Noda, M.
- Journal Title
  
  Infect Immun
  
  Volume: (In press) Issue: 5 Pages: 1803-1814
- DOI
  10.1128/iai.06164-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390127
[Journal Article] Subtilase cytotoxin enhances Escherichia coli survival in macrophages by suppression of nitric oxide production through the inhibition of NF-κB activation2012
- Author(s)
  Tsutsuki H, Yahiro K, Suzuki K, Suto A, Ogura K, Nagasawa S, Ihara H, Shimizu T, Nakajima H, Moss J, Noda M
- Journal Title
  
  Infect Immun
  
  Volume: 80 Issue: 11 Pages: 3939-51
- DOI
  10.1128/iai.00581-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591432, KAKENHI-PROJECT-23591458, KAKENHI-PROJECT-24390104
[Journal Article] Regulation of Subtilase cytotoxin (SubAB)-induced cell death by a PKR-like endoplasmic reticulum kinase (PERK)-dependent proteasome pathway in HeLa cells2012
- Author(s)
  Yahiro, K., H. Tsutsuki, K. Ogura, S. Nagasawa, J. Moss, M. Noda
- Journal Title
  
  Infect Immun. In press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390127
[Journal Article] Fatal hemonhage induced by subtilase cytotoxin from Shiga-toxigeaic Eschenchia coli.2011
- Author(s)
  Furukawa T., Yahiro K., Tsuji A. B., Terasaki Y., Morinaga N., Miyazaki M., Fukuda Y., Saga T., Moss J., Noda M.
- Journal Title
  
  Microb Pathog.
  
  Volume: 50 Pages: 159-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390127
[Journal Article] Fatal hemorrhage induced by subtilase cytotoxin from Shiga-toxigenic Escherichia coli2011
- Author(s)
  Furukawa, T., K. Yahiro, A. B. Tsuji, Y. Terasaki, N. Morinaga, M. Miyazaki, Y. Fukuda, T. Saga, J. Moss, M. Noda
- Journal Title
  
  Microb Pathog
  
  Volume: 50 Pages: 159-167
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390127
[Journal Article] Moss, and M. Noda. 2011. Identification of Subtilase cytotoxin (SubAB) receptors whose signaling, in association with SubAB-induced BiP cleavage, is responsible for apoptosis in HeLa cells2011
- Author(s)
  Yahiro, K., M. Satoh, N. Morinaga, H. Tsutsuki, K. Ogura, S. Nagasawa, F. Nomura, J
- Journal Title
  
  Infect Immun
  
  Volume: 79 Pages: 617-627
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390127
[Journal Article] Characterization of Cholix toxin-induced apoptosis in HeLa cells2011
- Author(s)
  Ogura K, Yahiro K, Tsutsuki H, Nagasawa S, Yamasaki S, Moss J, Noda M
- Journal Title
  
  J Biol Chem
  
  Volume: 286 Issue: 43 Pages: 37207-15
- DOI
  10.1074/jbc.m111.246504
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390127, KAKENHI-PROJECT-22790401
[Journal Article] Identification of subtilase cytotoxin (SubAB) receptors whose signaling, in association with SubAB-induced BiP cleavage, is responsible for apoptosis in HeLa cells.2011
- Author(s)
  Yahiro K., Satoh M., Morinaga N., Tsutsuki H., Ogura K., Nagasawa S., Nomura F., Moss J., Noda M.
- Journal Title
  
  Infect Immun.
  
  Volume: 79 Pages: 617-27
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390127
[Journal Article] Purification and characterization of bacterial cytotoxin receptors2010
- Author(s)
  Yahiro, K
- Journal Title
  
  Nippon Saikingaku Zasshi
  
  Volume: 65 Pages: 325-31
- NAID
  10028050248
- Data Source
  KAKENHI-PROJECT-21390127
[Journal Article] Subtilase cytotoxin induces apoptosis in HeLa cells by mitochondrial permeabilization via activation of Bax/Bak, independent of C/EBF-homologue protein (CHOP), or JNK signaling.2010
- Author(s)
  Yahiro K., Morinaga N., Moss J., Noda M.
- Journal Title
  
  Microb Pathog.
  
  Volume: 49 Pages: 153-63
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390127
[Journal Article] Subtilase cytotoxin induces apoptosis in HeLa cells by mitochondrial permeabilization via activation of Bax/Bak, independent of C/EBF-homologue protein (CHOP), Ire1alpha or JNK signaling2010
- Author(s)
  Yahiro, K., N. Morinaga, J. Moss, M. Noda
- Journal Title
  
  Microb Pathog
  
  Volume: 49 Pages: 153-163
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390127
[Journal Article] Novel subtilase cytotoxin produced by Shiga-toxigenic Escherichia coil induces apoptosis Vero cells via mitochondrial membrane damage2009
- Author(s)
  Matsuura G, Morinaga N, Yahiro K, Komine R, Moss J, Yoshida H, Noda M
- Journal Title
  
  Infection and Immunity 77
  
  Pages: 2919-2924
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390127
[Journal Article] Novel subtilase cytotoxin produced by Shiga-toxigenic Escherichia coli induces apoptosis in Vero cells via mitochondrial membrane damage2009
- Author(s)
  Matsuura, G., N. Morinaga, K. Yahiro, R. Komine, J. Moss, H. Yoshida, M. Noda
- Journal Title
  
  Infect Immun
  
  Volume: 77 Pages: 2919-2924
- Data Source
  KAKENHI-PROJECT-21390127
[Journal Article] Inhibitory effect of HBT on gastric injury by VacA of Helicobacter pyrori.2005
- Author(s)
  Yahiro, K. et al.
- Journal Title
  
  Helicobacter 10(in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209016
[Journal Article] H.pylori由来酸性フォスファターゼの大腸菌での発現系の確立と精製およびその性状解析2005
- Author(s)
  崔玉仙, 八尋錦之助, 等
- Journal Title
  
  日本外科学会雑誌 106
  
  Pages: 335-335
- Data Source
  KAKENHI-PROJECT-17659126
[Journal Article] Inhibitory effect of HBT on gastric injury by VacA of Helicobacter pylori2005
- Author(s)
  K.Yahiro, et al.
- Journal Title
  
  Helicobacter 10(印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15209016
[Journal Article] Inhibitory effects of polyphenols on gastric injury by Helicobacter pylori VacA toxin2004
- Author(s)
  K.Yahiro et al.
- Journal Title
  
  US-Japan Cholera and Other Bacterial Enteric Infections 40
  
  Pages: 84-85
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15209016
[Journal Article] Inhibitory effects of polyphenols on gastric injury by Helicobacter pylori VacA toxin.2004
- Author(s)
  Yahiro, K. et al.
- Journal Title
  
  US-Japan Cholera and Other Bacterial Enteric Infections 40
  
  Pages: 84-85
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209016
[Journal Article] Characterization of cholix toxin-induced apoptosis in hela cells
- Author(s)
  Ogura, K., K. Yahiro, H. Tsutsuki, S. Nagasawa, S. Yamasaki, J. Moss, M. Noda
- Journal Title
  
  J Biol Chem
  
  Volume: 286 Pages: 37207-37215
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] 腸管出血性大腸菌の産生する小胞体ストレス誘導毒素の宿主応答機能解析2021
- Author(s)
  八尋錦之助
- Organizer
  学校法人北里研究所第30回学会賞受賞者特別講演会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07534
[Presentation] 腸管出血性大腸菌の産生する小胞体ストレス誘導毒素の宿主応答解析2021
- Author(s)
  八尋錦之助
- Organizer
  学校法人北里研究所 2020年度第30回学会賞受賞者特別講演会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07534
[Presentation] SubABにより誘導される新規Lipocalin-2 の制御と細胞致死機構2021
- Author(s)
  八尋錦之助, 小倉康平, 後藤義幸, 伊豫田淳, 小林達也, 竹内裕紀, 大西真
- Organizer
  第67回トキシンシンポジウム
- Data Source
  KAKENHI-PROJECT-19K07534
[Presentation] SubAB induces a novel form of Lipocalin 2, which involves in STEC survival2021
- Author(s)
  八尋錦之助
- Organizer
  第94回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-19K07534
[Presentation] Cholix toxin, an eEF2 ADP-ribosyltransferase, induces cell death signaling pathway2020
- Author(s)
  八尋錦之助
- Organizer
  第93回日本生化学会大会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07534
[Presentation] 腸管出血性大腸菌の産生する小胞体ストレス誘導毒素の宿主受容体と宿主応答解析2020
- Author(s)
  八尋錦之助
- Organizer
  第31回生体防御学会学術総会(熊本)
- Invited
- Data Source
  KAKENHI-PROJECT-19K07534
[Presentation] ヒト肝臓細胞における新規Cholix結合膜蛋白質の同定と細胞致死機構の解明2020
- Author(s)
  八尋　錦之助、小倉　康平、寺﨑　泰弘、宮城　聡、山崎栄樹
- Organizer
  第93回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-19K07534
[Presentation] Mechanism of inhibition of Shiga-toxigenic Escherichia coli SubAB cytotoxicity by steroids and diacylglycerol analogues2019
- Author(s)
  Yahiro, K., S. Nagasawa, K. Ichimura, H. Takeuchi, K. Ogura, H. Tsutsuki, T. Shimizu, S. Iyoda, T. Shimizu, M. Ohnishi, H. Iwase, and M. Noda.
- Organizer
  U.S.-Japan Cooperative Medical Sciences Program (USJCMSP) 21st International Conference on Emerging Infectious Diseases in the Pacific Rim(Cholera and Other Bacterial Enteric Infections Panel Meeting)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08770
[Presentation] LEE-negative STECの産生するSubtilase cytotoxinの毒性阻害薬の検索と阻害機構の解明2018
- Author(s)
  八尋錦之助、永澤明佳、小倉康平、清水健、津々木博康、伊豫田淳、大西真
- Organizer
  第22回腸管出血性大腸菌研究会
- Data Source
  KAKENHI-PROJECT-16K08770
[Presentation] マウス感染モデルを用いた腸管出血性大腸菌毒素 Subtilase cytotoxinの機能解析2018
- Author(s)
  津々木博康、張田力、八尋錦之助、小野勝彦、伊豫田淳、勢戸和子、大西真、野田公俊、赤池孝章、澤智裕
- Organizer
  第91回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-16K08770
[Presentation] LEE-negative STECの産生するSubtilase cytotoxin (SubAB)の毒性阻害薬の検索と阻害機序の解明2018
- Author(s)
  八尋　錦之助、永澤明佳、小倉康平、清水　健、津々木博康、伊豫田　淳、大西　真、野田　公俊
- Organizer
  第91回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-16K08770
[Presentation] 日本ヘリコバクター学会　第二回教育講演・基礎2018
- Author(s)
  八尋錦之助
- Organizer
  日本ヘリコバクター学会
- Invited
- Data Source
  KAKENHI-PROJECT-16K08770
[Presentation] LEE-negative STECの産生するSubtilase cytotoxin (SubAB)の毒性阻害薬の検索と阻害機構の解析2017
- Author(s)
  八尋錦之助
- Organizer
  第64回トキシンシンポジウム
- Data Source
  KAKENHI-PROJECT-16K08770
[Presentation] 銀ナノ粒子の抗バイオフィルム活性2017
- Author(s)
  Kyaw Kaung、原田　彩花、市丸　裕晃、川越　嵩之、八尋　錦之助、森村　茂、小野　勝彦、津々木　博康、澤　智裕
- Organizer
  第33回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-16K08770
[Presentation] 腸管出血性大腸菌感染症における毒素研究2017
- Author(s)
  八尋　錦之助
- Organizer
  第90回日本細菌学会
- Place of Presentation
  仙台国際センター展示棟（宮城県・仙台市）
- Year and Date
  2017-03-19
- Data Source
  KAKENHI-PROJECT-16K08770
[Presentation] 細菌毒素が引き起こす多様な宿主応答分子機構：ピロリ菌や病原性大腸菌の話題を中心に2017
- Author(s)
  八尋錦之助
- Organizer
  真菌マンスリーセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-16K08770
[Presentation] 一酸化窒素による腸管出血大腸菌の志賀毒素産生亢進機構の解析2016
- Author(s)
  市村公敏、清水健、八尋錦之助、竹内裕紀、野田公俊
- Organizer
  第89回日本細菌学会
- Place of Presentation
  大阪府大阪市天王寺区
- Year and Date
  2016-03-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24390104
[Presentation] LEE-negative腸管出血性大腸菌の産生するSubtilase cytotoxin (SubAB) のストレスグラニュー形成機構2016
- Author(s)
  八尋　錦之助
- Organizer
  第63回トキシンシンポジウム
- Place of Presentation
  天童温泉滝の湯（山形県・天童市）
- Year and Date
  2016-07-14
- Data Source
  KAKENHI-PROJECT-16K08770
[Presentation] 腸管出血性大腸菌Subtilase cytotoxinによるインフラマーソム抑制機構の解析2016
- Author(s)
  津々木博康、ThianliZhang,小野勝彦、八尋錦之助、澤智裕、野田公俊
- Organizer
  第89回日本細菌学会
- Place of Presentation
  大阪
- Year and Date
  2016-03-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24390104
[Presentation] LEE-negative腸管出血性大腸菌の産生するSubtilase cytotoxin のストレスグラニュー形成メカニズム2016
- Author(s)
  八尋　錦之助
- Organizer
  第39回分子生物学会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K08770
[Presentation] Shiga-toxigenic Escherichia coli SubAB-induced ER stress causes stress granule formation in mammalian cells2016
- Author(s)
  Yahiro, K., H. Tsutsuki, K. Ogura, S. Iyoda, K. Ichimura, T. Shimizu, M. Ohnishi, K. Seto, J. Moss, and M. Noda.
- Organizer
  Bethesda, USA
- Place of Presentation
  Bethesda, USA
- Year and Date
  2016-01-13
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24390104
[Presentation] コレラ菌由来ADP-リボシル化毒素Cholix toxin による肝細胞致死機構2016
- Author(s)
  小倉康平、寺崎泰弘、秋山徹、八尋錦之助、野田公俊
- Organizer
  第63回トキシンシンポジウム
- Place of Presentation
  ほほえみの宿、滝の湯（山形・天童市）
- Year and Date
  2016-07-14
- Data Source
  KAKENHI-PROJECT-25460526
[Presentation] Effect of Shiga-toxigenic Escherichia coli-produced Subtilase cytotoxin(SubAB)on host cells2016
- Author(s)
  Yahiro, K.
- Organizer
  Invitation meeting
- Place of Presentation
  NIH/NHLBI, Bethesda,USA
- Year and Date
  2016-01-14
- Invited
- Data Source
  KAKENHI-PROJECT-24390104
[Presentation] Vibrio cholerae Cholix toxin induces hepatocyte cell death through ROS production and MAPKs activation.2016
- Author(s)
  小倉康平、八尋錦之助、秋山徹、野田公俊
- Organizer
  第89回日本細菌学会総会
- Place of Presentation
  大阪国際交流センター（大阪・大阪市）
- Year and Date
  2016-03-23
- Data Source
  KAKENHI-PROJECT-25460526
[Presentation] Characterization of Shiga-toxigenic Escherichia coli Sub AB uptake pathway in HeLa cells2014
- Author(s)
  Sayaka Nagasawa, Kinnosuke Yahiro, Kohei Ogura, Hiroyasu Tsutsuki, Masatoshi Noda
- Organizer
  第87回日本細菌学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24390104
[Presentation] Inhibition of autophagy by SubAB is regulated by PERK-dependent pathway in Hela cells2014
- Author(s)
  Kinnosuke Yahiro,　Masatoshi Noda
- Organizer
  第87回日本細菌学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24390104
[Presentation] Helicobacter pylori VacA-induced autophagy and apoptosis are regulated by LRP1.2013
- Author(s)
  Kinnosuke Yahiro, Masayuki Nakano, Masatoshi Noda, Toshiya Hirayama
- Organizer
  第86回日本細菌学会総会
- Place of Presentation
  幕張メッセ(千葉)
- Data Source
  KAKENHI-PROJECT-24390104
[Presentation] 腸管出血性大腸菌の産生するSubAB　の　PERKを介したアポトーシス制御機構2013
- Author(s)
  Kinnnosuke Yahiro, Hiroyasu Tsutsuki, Masatoshi Noda
- Organizer
  第60回毒素シンポジウム
- Place of Presentation
  兵庫県
- Data Source
  KAKENHI-PROJECT-24390104
[Presentation] Subtilase cytotoxin induces stress granule formation through PERK dependent pathway2013
- Author(s)
  Hiroyasu Tsutsuki, Kinnosuke Yahiro, Tohru Shimizu, Masatoshi Noda
- Organizer
  第86回日本細菌学会総会
- Place of Presentation
  幕張メッセ(千葉)
- Data Source
  KAKENHI-PROJECT-24390104
[Presentation] 腸管出血性大腸菌の産生するSubABのPERKを介したアポトーシス制御機構2012
- Author(s)
  八尋錦之助、津々木博康、小倉康平、野田公俊
- Organizer
  第59回トキシンシンポジウム
- Place of Presentation
  とかちプラザ(北海道)
- Data Source
  KAKENHI-PROJECT-24390104
[Presentation] Inhibitory effect of subtilase cytotoxin on LPS-induced nitric oxide production by macrophages.2012
- Author(s)
  Hiroyasu Tsutsuki, Kinnosuke Yahiro, Takeshi Shimizu and Masatoshi Noda
- Organizer
  THE 33rd NAITO CONFERENCE ON Oxygen Biology : Hypoxia, Oxidative Stress and Diseases.
- Place of Presentation
  シャトレーゼガトーキングダム札幌(北海道)
- Data Source
  KAKENHI-PROJECT-24390104
[Presentation] Molecular mechanism of inhibitory effect of SubAB on nitric oxide production by macrophages2012
- Author(s)
  津々木博康、八尋錦之助、清水健、野田公俊
- Organizer
  第85回日本細菌学会総会
- Place of Presentation
  長崎ブリックホール(長崎)(招待講演)
- Year and Date
  2012-03-27
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] SubAB-induced apoptosis is regulated by a PERK-dependent proteasome pathway in HeLa cells2012
- Author(s)
  八尋錦之助、津々木博康、小倉康平、永澤明佳、盛永直子、野田公俊
- Organizer
  第85回日本細菌学会総会
- Place of Presentation
  長崎ブリックホール(長崎)
- Year and Date
  2012-03-27
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] Diversity in the mechanism of human cell death caused by ADP-ribosyltransferase Cholix toxin2012
- Author(s)
  小倉康平, 八尋錦之助, 山崎伸二, 野田公俊
- Organizer
  第85回日本細菌学会総会
- Place of Presentation
  長崎
- Year and Date
  2012-03-27
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] Diversity in the mechanism of human celldeath caused by ADP-ribosyltransferaseCholix toxin2012
- Author(s)
  小倉康平, 八尋錦之助, 山崎伸二, 野田公俊
- Organizer
  第85回日本細菌学会総会
- Place of Presentation
  長崎ブリックホール(長崎)
- Year and Date
  2012-03-27
- Data Source
  KAKENHI-PROJECT-22790401
[Presentation] Regulation of Subtilase cytotoxin (SubAB)-induced cell death by a PKR-like endoplasmic reticulum kinase (PERK)-dependent proteasome pathway in HeLa cells2012
- Author(s)
  Kinnosuke Yahiro, Hiroyasu Tsutsuki, Kohei Ogura, Sayaka Nagasawa, Takeshi Shimizu, Joel Moss, Masatoshi Noda
- Organizer
  7th US-Japan Cholera and Other Bacterial Enteric Infections Joint Panel Meeting.
- Place of Presentation
  千葉大学薬学部創立120周年記念講堂(千葉)
- Data Source
  KAKENHI-PROJECT-24390104
[Presentation] Subtilase cytotoxin enhances E. coli survival in macrophages by suppression of nitric oxide production through the inhibition of NF-kB activation.2012
- Author(s)
  Hiroyasu Tsutsuki, Kinnosuke Yahiro, Takeshi Shimizu, Masatoshi Noda
- Organizer
  47th US Japan Cholera and Other Bacterial Enteric Infections Joint Panel Meeting.
- Place of Presentation
  千葉大学薬学部創立120周年記念講堂(千葉)
- Data Source
  KAKENHI-PROJECT-24390104
[Presentation] Molecular mechanism of inhibitory effect of2012
- Author(s)
  津々木博康, 八尋錦之助, 清水健, 野田公俊
- Organizer
  SubAB on nitric oxide production by macrophages
- Place of Presentation
  長崎
- Year and Date
  2012-03-27
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] Characterization of V cholerae Cholix-induced cell death mechanism in human cell line2012
- Author(s)
  Kinnosuke Yahiro
- Organizer
  The 11^<th> Korea-Japan International Symposium on Microbiology
- Place of Presentation
  韓国
- Year and Date
  2012-09-14
- Data Source
  KAKENHI-PROJECT-24390104
[Presentation] SubAB-induced apoptosis is regulated by a PERK-dependent proteasome pathway in HeLa cells2012
- Author(s)
  八尋錦之助, 津々木博康, 小倉康平, 永澤明佳, 盛永直子, 野田公俊
- Place of Presentation
  長崎
- Year and Date
  2012-03-27
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] 腸管出血性大腸菌の産生する志賀毒素以外の毒素2012
- Author(s)
  八尋錦之助、津々木博康、小倉康平、野田公俊
- Organizer
  第95回日本細菌学会関東支部総会
- Place of Presentation
  ホテル日航東京(東京)
- Data Source
  KAKENHI-PROJECT-24390104
[Presentation] Diversity in the mechanism of human cell death caused by ADP-ribosyl transferase Cholix toxin2012
- Author(s)
  小倉康平、八尋錦之助、山崎伸二、野田公俊
- Organizer
  第85回日本細菌学会総会
- Place of Presentation
  長崎ブリックホール(長崎)
- Year and Date
  2012-03-27
- Data Source
  KAKENHI-PROJECT-22790401
[Presentation] コレラ菌由来のADP-リボシルトランスフェラーゼ活性を有するCholix toxinが引き起こすアポトーシスシグナル伝達機構の解析2011
- Author(s)
  小倉康平、八尋錦之助、山崎伸二、野田公俊
- Organizer
  第58回トキシンシンポジウム
- Place of Presentation
  順天堂大学(東京)(招待講演)
- Year and Date
  2011-07-06
- Data Source
  KAKENHI-PROJECT-22790401
[Presentation] 腸管出血性大腸菌の産生するSubABのマウスにおける病態発現解析2011
- Author(s)
  八尋錦之助, 古川健, 寺崎泰弘, 辻厚至, 盛永直子, 野田公俊
- Organizer
  第58回トキシンシンポジウム
- Place of Presentation
  東京
- Year and Date
  2011-07-06
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] コレラ菌由来のADP-リボシルトランスフェラーゼ活性を有するCholix toxinが引き起こすアポトーシスシグナル伝達機構の解析2011
- Author(s)
  小倉康平, 八尋錦之助, 山崎伸二, 野田公俊
- Organizer
  第58回トキシンシンポジウム
- Place of Presentation
  順天堂大学(東京)
- Year and Date
  2011-07-06
- Data Source
  KAKENHI-PROJECT-22790401
[Presentation] Apoptotic signaling pathways in HeLa cells induced by Cholix toxin of Vibrio cholerae2011
- Author(s)
  小倉康平, 八尋錦之助, 山崎伸二, 野田公俊
- Organizer
  nternational Union of Microbiological Societies 2011 Congress
- Place of Presentation
  北海道
- Year and Date
  2011-09-10
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] Subtilase cytotoxin inhibits the production of nitric oxide from macrophage2011
- Author(s)
  津々木博康, 八尋錦之助, 清水健, 野田公俊
- Place of Presentation
  北海道
- Year and Date
  2011-09-10
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] コレラ菌由来のADP-リボシルトランスフェラーゼ活性を有するCholix toxinが引き起こすアポトーシスシグナル伝達機構の解析2011
- Author(s)
  小倉康平, 八尋錦之助, 山崎伸二, 野田公俊
- Organizer
  第58回トキシンシンポジウム
- Year and Date
  2011-07-06
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] Apoptotic signaling pathways in HeLa cells induced by Cholix toxin of Vibrio cholerae2011
- Author(s)
  Ogura K, Yahiro K, Yamasaki S, Noda M
- Organizer
  International Union of Microbiological Societies 2011 Congress
- Place of Presentation
  札幌コンベンションセンター(北海道)
- Year and Date
  2011-09-10
- Data Source
  KAKENHI-PROJECT-22790401
[Presentation] 腸管出血性大腸菌の産生するSubABのマウスにおける病態発現解析2011
- Author(s)
  八尋錦之助、古川健、寺崎泰弘、辻厚至、盛永直子、野田公俊
- Organizer
  第58回トキシンシンポジウム
- Place of Presentation
  順天堂大学(東京)(招待講演)
- Year and Date
  2011-07-06
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] Apoptotic signaling pathways in HeLacells induced by Cholix toxin of Vibriocholerae2011
- Author(s)
  Ogura K, Yahiro K, Yamasaki S, Noda M
- Organizer
  International Union of Microbiological Societies 2011 Congress
- Place of Presentation
  札幌コンベンションセンター(北海道)
- Year and Date
  2011-09-10
- Data Source
  KAKENHI-PROJECT-22790401
[Presentation] Characterization of Subtilase cytotoxin-induced apoptotic signaling pathway in HeLa cells2011
- Author(s)
  八尋錦之助, 盛永直子, 野田公俊
- Organizer
  International Union of Microbiological Societies
- Place of Presentation
  北海道
- Year and Date
  2011-09-10
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] 腸管出血性大腸菌の産生するSubtilase cytotoxin (SubAB)の細胞内侵入機序の解析2011
- Author(s)
  永澤明佳、八尋錦之助、茂谷久子、岩瀬博太郎。野田公俊
- Organizer
  第58回トキシンシンポジウム
- Place of Presentation
  順天堂大学(東京)(招待講演)
- Year and Date
  2011-07-06
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] 腸管出血性大腸菌の産生する新規SubABトキシンによるNO産生抑制機構の解明2011
- Author(s)
  津々木博康, 八尋錦之助, 清水健, 野田公俊
- Organizer
  第58回トキシンシンポジウム
- Place of Presentation
  東京
- Year and Date
  2011-07-06
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] Characterization of Subtilase cytotoxin-induced apoptotic signaling pathway in HeLa cells2011
- Author(s)
  八尋錦之助、盛永直子、野田公俊
- Organizer
  International Union of Microbiological Societies 2011 Congress
- Place of Presentation
  札幌コンベンションセンター(北海道)(招待講演)
- Year and Date
  2011-09-10
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] 腸管出血性大腸菌の産生する新規SubABトキシンによるNO産生抑制機構の解明2011
- Author(s)
  津々木博康、八尋錦之助、清水健、野田公俊
- Organizer
  第58回トキシンシンポジウム
- Place of Presentation
  順天堂大学(東京)(招待講演)
- Year and Date
  2011-07-06
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] Subtilase cytotoxin inhibits the production of nitric oxide from macrophage2011
- Author(s)
  津々木博康、八尋錦之助、清水健、野田公俊
- Organizer
  International Union of Microbiological Societies 2011 Congress
- Place of Presentation
  札幌コンベンションセンター(北海道)
- Year and Date
  2011-09-10
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] Subtilase cytotoxin produced by Escherichia coli induces fatal hemorrhage in mice2011
- Author(s)
  八尋錦之助、古川健、寺崎泰弘、辻厚至、清水健、盛永直子、野田公俊
- Organizer
  46^<th> US-Japan Cholera and Other Bacterial Enteric Infections Joint Panel Meeting
- Place of Presentation
  インド
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] 腸管出血性大腸菌が産生するSubtilase cytotoxinはマクロファージのNO産生を抑制する2011
- Author(s)
  津々木博康, 八尋錦之助, 清水健, 野田公俊
- Organizer
  第96回日本細菌学会関東支部総会
- Place of Presentation
  東京
- Year and Date
  2011-10-06
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] 腸管出血性大腸菌の産生するSubtilase cytotoxin(SubAB)の細胞内侵入機序の解析2011
- Author(s)
  永澤明佳, 八尋錦之助, 茂谷久子, 岩瀬博太郎, 野田公俊
- Organizer
  第58回トキシンシンポジウム
- Place of Presentation
  順天堂大学(東京)
- Year and Date
  2011-07-06
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] 腸管出血性大腸菌の産生する新規SubABトキシンによるNO産生抑制機構の解明2010
- Author(s)
  津々木博康, 八尋錦之助, 清水健, 野田公俊
- Organizer
  インターラボセミナー
- Place of Presentation
  千葉
- Year and Date
  2010-12-11
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] Subtilase cytotoxin induces activation of Bax/Bak, leading to cytochromec release and apoptosis2010
- Author(s)
  盛永直子、八尋錦之助、野田公俊
- Organizer
  日本細菌学会
- Place of Presentation
  横浜
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] Subtilase cytotoxin induces activation of Bax/Bak, leading to cytochrome c release and apoptosis2010
- Author(s)
  盛永直子, 八尋錦之助, 野田公俊
- Organizer
  第83回日本細菌学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] コレラ菌由来の新規外毒素が示す標的細胞致死活性2010
- Author(s)
  小倉康平、八尋錦之助、野田公俊
- Organizer
  インターラボセミナー:Kingdomを超えて
- Place of Presentation
  千葉大学真菌医学センター
- Year and Date
  2010-12-11
- Data Source
  KAKENHI-PROJECT-22790401
[Presentation] コレラ菌由来の新規外毒素が示す標的細胞致死活性2010
- Author(s)
  小倉康平, 八尋錦之助, 野田公俊
- Organizer
  インターラボセミナー
- Place of Presentation
  千葉
- Year and Date
  2010-12-11
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] Identification of Subtilase cytotoxin receptors in HeLa cells2010
- Author(s)
  八尋錦之助, 盛永直子, 野田公俊
- Organizer
  第83回日本細菌学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] 腸管出血性大腸菌の産生する Subtilase cytotoxin (SubAB)の毒性発現機序の解析2010
- Author(s)
  八尋錦之助, 盛永直子, 野田公俊
- Organizer
  第57回トキシンシンポジウム
- Place of Presentation
  滋賀
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] 腸管Hi.血性大腸菌の産生するSubtilase cytotoxin(SubAB:)の毒性発現機序の解析2010
- Author(s)
  八尋錦之助、盛永直子、野田公俊
- Organizer
  第57回トキシンシンポジウム
- Place of Presentation
  滋賀県
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] Identification of SubAB receptor and its signaling pathway associated with BiP cleavage leading to apoptosis2010
- Author(s)
  八尋錦之助, 盛永直子, 野田公俊
- Organizer
  45th US-Japan Cholera and Other Baceterial Enteric Infections Joint Panel Meeting
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] Subtilase cytotoxin induces apoptosis in HeLa cells via mitochorndrial membrane damage2009
- Author(s)
  Yahiro, K., Morinaga, N., Noda, M
- Organizer
  Cholera and other bacterial enteric infections
- Place of Presentation
  San Diego, USA
- Year and Date
  2009-10-13
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] プロテオーム解析による細菌毒素宿主受容体の同定と性状解析2009
- Author(s)
  八尋錦之助, 盛永直子, 野田公俊
- Organizer
  第6回千葉疾患プロテオミクス研究会
- Place of Presentation
  千葉県
- Year and Date
  2009-12-06
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] ubtilase cytotoxin induced apoptosis in HeLa cells via mitochondrial membrane damage2009
- Author(s)
  八尋錦之助, 盛永直子, 野田公俊
- Organizer
  44th US-Japan Cholera and Other Bacterial Enteric Infections Joint Panel Meeting
- Place of Presentation
  サンディエゴ、USA
- Data Source
  KAKENHI-PROJECT-21390127
[Presentation] 腸管出血性大腸菌の産生するSubAB の細胞障害機構の解明
- Author(s)
  八尋　錦之助、野田　公俊
- Organizer
  第61回トキシンシンポジウム
- Place of Presentation
  ルネッサンスリゾートナルト（徳島県・鳴門市）
- Year and Date
  2014-09-03 – 2014-09-05
- Data Source
  KAKENHI-PROJECT-24390104
[Presentation] 腸管出血性大腸菌の産生するSubtilase cytotoxin (SubAB)はアクチン及び脂質ラフト依存的に細胞内に取り込まれる」（若手奨励賞受賞）
- Author(s)
  永澤明佳、小倉康平、津木博康、岩瀬博太郎、野田公俊、八尋錦之助
- Organizer
  第61回トキシンシンポジウム
- Place of Presentation
  ルネッサンスリゾートナルト（徳島県・鳴門市）
- Year and Date
  2014-09-03 – 2014-09-05
- Data Source
  KAKENHI-PROJECT-24390104
[Presentation] 腸管出血性大腸菌の産生するSubtilase cytotoxin の細胞侵入機構の解析
- Author(s)
  永澤明佳，八尋錦之助，齋藤久子，岩瀬博太郎，野田公俊
- Organizer
  第 97 回日本細菌学会関東支部総会
- Place of Presentation
  東京ドームホテル（東京都・文京区）
- Year and Date
  2014-10-30 – 2014-10-31
- Data Source
  KAKENHI-PROJECT-24390104
[Presentation] Shiga-toxigenic Escherichia coli produced SubAB enters via lipid-raft- and an actin-dependent endocytosis in HeLa cells.
- Author(s)
  八尋錦之助、永澤明佳，齋藤久子，岩瀬博太郎，野田公俊
- Organizer
  49th U.S.-Japan Conference on Cholera and Other Enteric Bacterial Infections
- Place of Presentation
  フロリダ（米国）
- Year and Date
  2015-01-14 – 2015-01-16
- Data Source
  KAKENHI-PROJECT-24390104

1. NODA Masatoshi (60164703)

# of Collaborated Projects: 5 results

# of Collaborated Products: 64 results
2. MORINAGA Naoko (20092108)

# of Collaborated Projects: 4 results

# of Collaborated Products: 24 results
3. OGURA Kohei (00586612)

# of Collaborated Projects: 4 results

# of Collaborated Products: 22 results
4. KUWABARA Satoshi (70282481)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. SHIMIZU Takeshi (70312840)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
6. TSUTSUKI Hiroyasu (40586608)

# of Collaborated Projects: 2 results

# of Collaborated Products: 30 results
7. MORI Masahiro (70345023)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
8. HITAYAMA Toshiya (50050696)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. MAKINO Souichi (30181621)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. AOYAMA Nobuo (30243299)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. WADA Akihiro (70253698)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 三宅眞実 (10251175)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. YAMAJI Toshiyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. TERASAKI Mika

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. SUTO Akira

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. SUZUKI Kotaro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 児島将康

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 伊豫田淳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 寺崎泰弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 中島裕史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 澤智裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yahiro Kinnosuke 八尋 錦之助

YAHIRO Kinnosuke 八尋 錦之助

Research Projects

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Co-Researchers

Functional analysis of exosome siRNA in Cholix-induced hepatic cell deathPrincipal Investigator

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Mechanism of inhibition of Shiga-toxigenic Escherichia coli SubAB cytotoxicity by steroids and diacylglycerol analoguesPrincipal Investigator

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Elucidation of the mechanism of Cholix cytotoxicity via its receptor.Principal Investigator

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Elucidation of the pathogenic reinforcement action of enterohemorrhagic Escherichia coli produced SubAB

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Analysis of human cell death mechanism caused by ADP-ribosyltransferase Cholix toxinPrincipal Investigator

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Elucidation of Shiga-toxigenic Escherichia coli produced Subtilase cytotoxin-induced cell damage mechanism.

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H.pylori由来酸性ホスファターゼの宿主応答制御機序の解析Principal Investigator

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Development of a quick neutralization therapy for the diseases caused by bacterial toxins

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Development of a quick diagnosis of Haemophilus influenzea Which induces Guillain- Barre syndrome.

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Basic research for H. pylori component vaccine

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[Book] Handbook of Proteolytic Enzymes, 3^<rd> Edition ［Cytotoxin SubAB (Chapter 694)］2013

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[Journal Article] A novel endoplasmic stress mediator, Kelch domain containing 7B (KLHDC7B), increased Harakiri (HRK) in the SubAB-induced apoptosis signaling pathway2021

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[Journal Article] Involvement of protein disulfide isomerase in subtilase cytotoxin-induced cell death in HeLa cells2020

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[Journal Article] Host response to the Subtilase cytotoxin produced by locus of enterocyte effacement (LEE)-negative Shiga-toxigenic Escherichia coli (STEC)2020

Yahiro Kinnosuke 八尋錦之助

YAHIRO Kinnosuke 八尋錦之助

[Journal Article] Helicobacter pylori Vacuolating Cytotoxin A Causes Anorexia and Anxiety via 1 Hypothalamic 　　Urocortin 1 in Mice2019