Takeshita Kohei 竹下浩平

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TAKESITA Kouhei 竹下浩平

TAKESHITA Kohei 竹下浩平

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Researcher Number	80346808
Other IDs
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 放射光科学研究センター, 研究員
Affiliation (based on the past Project Information) *help	2021 – 2025: 国立研究開発法人理化学研究所, 放射光科学研究センター, 研究員 2017: 大阪大学, たんぱく質研究所, 招へい教員 2017: 大阪大学, 蛋白質研究所, 特任助教 2013: 大阪大学, たんぱく質研究所, 招へい研究員 2012: 大阪大学, 医学(系)研究科(研究院), 研究員 2011: 大阪大学, たんぱく質研究所, 招へい研究員
Review Section/Research Field	Principal Investigator Basic Section 38030:Applied biochemistry-related / Functional biochemistry Except Principal Investigator Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Broad Section F / Basic Section 43060:System genome science-related / Medium-sized Section 38:Agricultural chemistry and related fields / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Physical pharmacy / Biophysics
Keywords	Principal Investigator X線結晶構造解析 / 相関構造解析 / ゲノム編集タンパク質 / 単粒子解析 / 小角散乱 / ゲノム編集 / 構造生物学 / タンパク質科学 / Cas3 / メチル化模様維持 / エピジェネティクス / DNAメチルトランスフェラーゼ１ … More Except Principal Investigator … More CRISPR-Cas3 / 相互作用 / 創薬 / ドッキングシミュレーション / 構造解析 / 結核菌 / マウス / in vivoゲノム編集 / 診断薬 / 脂質ナノ粒子 / 遺伝子改変マウス / 受精卵 / コラテラル切断 / 原子間力顕微鏡 / モデル動物 / 核酸検出法 / in vivoゲノム編 / in vitroゲノム編集 / ゲノム編集 / 天然ゴム / フラボノイド / タンパク質間相互作用 / メタボロン / 植物特化代謝 / フラボノイドメタボロン / 天然ゴム生合成マシナリ / 植物代謝マシナリ / エピゲノム編集 / 精密ゲノム編集 / シミュレーション / X線結晶構造解析 / 結晶構造解析 / 作用機序解明 / 抗結核薬 / 膜蛋白質 / 分子シミュレーション / 膜タンパク質 / 膜輸送機構 / プロトン透過 / 分子動力学シミュレーション / 生体膜間物質輸送 Less

Development of precise genome engineering methods using modiied CRISPR-Cas3
- Principal Investigator
  
  吉見一人
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43060:System genome science-related
- Research Institution
  The University of Tokyo
植物特化代謝における超分子的代謝マシナリの形成：多元構造解析による統合的理解
- Principal Investigator
  
  中山亨
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  Tohoku University
Molecular dissection of plant specialized metabolism machineries
- Principal Investigator
  
  中山亨
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section F
- Research Institution
  Tohoku University
Development of novel gene editing methods based on the elucidation of the Type I CRISPR genome editing mechanisms
- Principal Investigator
  
  真下知士
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  The University of Tokyo
Integrative Structural Biology Studies on the development for safe and efficient Cas3 genome editing toolsPrincipal Investigator
- Principal Investigator
  
  竹下浩平
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38030:Applied biochemistry-related
- Research Institution
  Institute of Physical and Chemical Research
Application to elucidate the function of targets for novel anti-tuberculosis drugs and to develop detection kits
- Principal Investigator
  
  YAMASHITA Taku
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Mukogawa Women's University
A Simulation Study on the Mechanism of Membrane Voltage Depended Protein VSOP
- Principal Investigator
  
  Yonezawa Yasushige
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  Kindai University
Origination of antibiotic drugs for tuberculosis based on the structural analyses of novel target proteins
- Principal Investigator
  
  YAMASHITA Taku
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Mukogawa Women's University
Structural study of maintenance methylation by Dnmt1Principal Investigator
- Principal Investigator
  
  TAKESHITA Kohei
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Osaka University

All 2024 2023 2022 2017 2014 2012 2011 Other

All Journal Article Presentation Book Patent

[Book] DNA Methyltransferases - Role and Function, 「Domain Structure of the Dnmt1, Dnmt3a, and Dnmt3b DNA Methyltransferases」2022
- Author(s)
  Tajima Shoji、Suetake Isao、Takeshita Kohei、Nakagawa Atsushi、Kimura Hironobu、Song Jikui
- Total Pages
  561
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-23K23533
[Journal Article] Structural‐Functional Correlations between Unique N‐terminal Region and C‐terminal Conserved Motif in Short‐chain <i>cis</i>‐Prenyltransferase from Tomato2024
- Author(s)
  Imaizumi Riki、Matsuura Hiroaki、Yanai Taro、Takeshita Kohei、Misawa Shuto、Yamaguchi Haruhiko、Sakai Naoki、Miyagi‐Inoue Yukino、Suenaga‐Hiromori Miki、Waki Toshiyuki、Kataoka Kunishige、Nakayama Toru、Yamamoto Masaki、Takahashi Seiji、Yamashita Satoshi
- Journal Title
  
  ChemBioChem
  
  Volume: 25 Issue: 7
- DOI
  10.1002/cbic.202300796
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22KJ1466, KAKENHI-PLANNED-19H05783, KAKENHI-PROJECT-23H05470
[Journal Article] A large pocket structure surrounding the catalytic center in the BCG protein from Mycobacterium tuberculosis2024
- Author(s)
  Takeshita, K., Sakai, N., Ueno, G., Horie, M., Tsujino, H., Arisawa, M.,Yamamoto, M., Arai, M., and Yamashita, T.
- Journal Title
  
  BioRxiv
  
  Volume: -
- DOI
  10.1101/2024.05.14.591795
- Open Access
- Data Source
  KAKENHI-PROJECT-21K06555
[Journal Article] Large-scale serosurveillance of COVID-19 in Japan: Acquisition of neutralizing antibodies for Delta but not for Omicron and requirement of booster vaccination to overcome the Omicron’s outbreak2022
- Author(s)
  Ren Zhenxiao、Nishimura Mitsuhiro、Tjan Lidya Handayani、Furukawa Koichi、Kurahashi Yukiya、Sutandhio Silvia、Aoki Kaito、Hasegawa Natsumi、Arii Jun、Uto Kenichi、Matsui Keiji、Sato Itsuko、Saegusa Jun、Godai Nonoka、Takeshita Kohei、Yamamoto Masaki、Nagashima Tatsuya、Mori Yasuko
- Journal Title
  
  PLOS ONE
  
  Volume: 17 Issue: 4 Pages: 266270-266270
- DOI
  10.1371/journal.pone.0266270
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K23533
[Journal Article] Dynamic mechanisms of CRISPR interference by Escherichia coli CRISPR-Cas32022
- Author(s)
  Yoshimi Kazuto、Takeshita Kohei、Kodera Noriyuki、Shibumura Satomi、Yamauchi Yuko、Omatsu Mine、Umeda Kenichi、Kunihiro Yayoi、Yamamoto Masaki、Mashimo Tomoji
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 4917-4917
- DOI
  10.1038/s41467-022-32618-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K04849, KAKENHI-PROJECT-22K19238, KAKENHI-PROJECT-19KK0401, KAKENHI-PROJECT-20H00327, KAKENHI-PROJECT-18KK0307, KAKENHI-PROJECT-23K23533
[Journal Article] CRISPR-Cas3-based diagnostics for SARS-CoV-2 and influenza virus2022
- Author(s)
  Yoshimi K, Takeshita K, Yamayoshi S, Shibumura S, Yamauchi Y, Yamamoto M, Yotsuyanagi H, Kawaoka Y, Mashimo T.
- Journal Title
  
  iScience
  
  Volume: 25 Issue: 2 Pages: 103830-103830
- DOI
  10.1016/j.isci.2022.103830
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16025, KAKENHI-PROJECT-18H03974, KAKENHI-PROJECT-19KK0401, KAKENHI-PROJECT-23K23533
[Journal Article] Domain Structure of the Dnmt1, Dnmt3a, and Dnmt3b DNA Methyltransferases2022
- Author(s)
  Tajima Shoji、Suetake Isao、Takeshita Kohei、Nakagawa Atsushi、Kimura Hironobu、Song Jikui
- Journal Title
  
  Adv Exp Med Biol
  
  Volume: 1389 Pages: 45-68
- DOI
  10.1007/978-3-031-11454-0_3
- ISBN
  9783031114533, 9783031114540
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K23533
[Journal Article] The DNA methyltransferase Dnmt1 directly interacts with the SET and RING finger associated (SRA) domain of the multifunctional protein Uhrf1 to facilitate accession of the catalytic center to hemi-methylated DNA.2014
- Author(s)
  A. C. Berkyurek, I. Suetake, K. Arita, K. Takeshita, A. Nakagawa, M. Shirakawa, and S. Tajima.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 289 Issue: 7 Pages: 379-386
- DOI
  10.1074/jbc.m113.528893
- NAID
  120006770872
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23770145
[Journal Article] The DNA methyltransferase Dnmt1 directly interacts with the SET and RING finger-associated (SRA) domain of the multifunctional protein Uhrf1 to facilitate accession of the catalytic center to hemi-methylated DNA2014
- Author(s)
  Berkyurek AC, Suetake I, Arita K, Takeshita K, Nakagawa A, Shirakawa M, Tajima S
- Journal Title
  
  J Biol Chem
  
  Volume: 289(1) Issue: 1 Pages: 379-86
- DOI
  10.1074/jbc.m113.523209
- NAID
  120006770872
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23770145, KAKENHI-PUBLICLY-24113711, KAKENHI-PUBLICLY-24116515, KAKENHI-PROJECT-24570153, KAKENHI-PROJECT-24651214, KAKENHI-PROJECT-25291025
[Journal Article] Structural insight into maintenance methylation by mouse DNA methyltransferase 1 (Dnmt1)2011
- Author(s)
  Takeshita, K., Suetake, I., Yamashita, E., Suga, M., Narita, H., Nakagawa, A., Tajima, S.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA
  
  Volume: 108 Pages: 9055-9059
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23770145
[Journal Article] Structual insight into maintenance methylation by mouse DNA methyltransferase(Dnmt1)2011
- Author(s)
  Takeshita K, Suetake I, Yamashita E, Suga M, Narita H, Nakagawa A, and Tajima S
- Journal Title
  
  PNAS
  
  Volume: 108 Issue: 22 Pages: 9055-9059
- DOI
  10.1073/pnas.1019629108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570136, KAKENHI-PROJECT-22370053, KAKENHI-PROJECT-23770145
[Patent] Methods for producing cas3 proteins2023
- Inventor(s)
  真下, 吉見, 竹下ら
- Industrial Property Rights Holder
  真下, 吉見, 竹下ら
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Overseas
- Data Source
  KAKENHI-PROJECT-23K23533
[Presentation] フラボノイド代謝における鍵酵素と生成物特異性を制御するタンパク質の複合体結晶構造2024
- Author(s)
  今泉璃城，和氣駿之，竹下浩平，安田あおい，松浦滉明，中多舜，坂井直樹，片岡邦重，高橋征司，山本雅貴，山下哲，中山亨
- Organizer
  日本農芸化学会2024年度東京大会
- Data Source
  KAKENHI-PROJECT-23H05470
[Presentation] マイクロ流路デバイスを用いた化合物スクリーニング系の構築2023
- Author(s)
  小林ことり、上野剛、真栄城正寿、西岡晶子、坂井直樹、河村高志、松浦滉明、竹下浩平、山本雅貴
- Organizer
  第23回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-23K23533
[Presentation] 汎用的P1"非依存的 TEV プロテアーゼの開発2023
- Author(s)
  大恵千翔、小杉慎吾、峯岸恭孝、上野剛、熊坂崇、山本雅貴、竹下浩平
- Organizer
  第23回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-23K23533
[Presentation] てんかん発作と関連するラットチオレドキシン変異体の結晶構造2023
- Author(s)
  馬場匠望、大内田守、大守伊織、上野剛、山本雅貴、竹下浩平
- Organizer
  第23回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-23K23533
[Presentation] CRISPR-Cas3の活性化機構についての構造的洞察2022
- Author(s)
  松美音, 吉見一人, 渋村里美, 山本雅紀, 真下知士, 竹下浩平
- Organizer
  R4年度バイオダイナミクス研究会(兵庫県立大学)
- Data Source
  KAKENHI-PROJECT-23K23533
[Presentation] CRISPR-Cas3の活性化機構についての構造的洞察2022
- Author(s)
  尾松美音, 吉見一人, 渋村里美, 山本雅紀, 真下知士, 竹下浩平
- Organizer
  第22回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-23K23533
[Presentation] 汎用的P1'非依存的TEVプロテアーゼの開発2022
- Author(s)
  大恵千翔, 小杉慎吾, 峯岸恭孝, 吾郷日出夫, 熊坂崇, 山本雅貴, 竹下浩平
- Organizer
  第22回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-23K23533
[Presentation] 放射光を用いたSPring-8創薬スクリーニングパイプラインの開発2022
- Author(s)
  坂井直樹, 松浦滉明, 平田邦生, 竹下浩平, 奥村英夫, 水野伸宏, 村上博則, 増永拓也, 仲村勇樹, 上野剛, 馬場清喜, 長谷川和也, 熊坂崇, 山本雅貴
- Organizer
  第22回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-23K23533
[Presentation] 電位依存性プロトンチャネルVSOP/Hv1の電場中での動態の解析2017
- Author(s)
  近藤寛子，米澤康滋，宮下尚之，岩城雅代，竹下浩平，藤原祐一郎，城田松之，木下賢吾，岡村康司，中川敦史，神取秀樹，鷹野優
- Organizer
  第55回生物物理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-15K07037
[Presentation] 新規抗結核ターゲットであるBCGタンパク質のX線結晶構造解析2017
- Author(s)
  竹下浩平
- Organizer
  第17回日本蛋白質科学会年会（仙台）
- Data Source
  KAKENHI-PROJECT-15K07909
[Presentation] Dnmt1（RFTS）とUhrf1（SRA）の相互作用によりDNAは触媒中心に近づけるようになる2014
- Author(s)
  アーメット・キャン・ベルキュレック、末武勲、有田恭平、竹下浩平、中川敦史、白川昌宏、田嶋正二
- Organizer
  第8回エピジェネティクス研究会
- Place of Presentation
  伊藤国際学術研究センター（東京大学構内）
- Data Source
  KAKENHI-PROJECT-23770145
[Presentation] Dnmt1によるDNA維持メチル化活性は領域の大きな再配置を伴う反応である2012
- Author(s)
  末武勲、中村達郎、ベルキュレクアハメトジャン、竹下浩平、中川敦史、田嶋正三
- Organizer
  第6回日本エヒジェネティクス研究会年会
- Place of Presentation
  学術総合センター
- Data Source
  KAKENHI-PROJECT-23770145
[Presentation] Dnmt1によるメチル化模様維持機構に関する構造生物学的研究2011
- Author(s)
  竹下浩平、末武勲、山下栄樹、菅倫寛、成田宏隆、中川敦史、田嶋正三
- Organizer
  第11回日本蛋白質科学会年会
- Place of Presentation
  ホテル阪急エキスポミーク
- Data Source
  KAKENHI-PROJECT-23770145
[Presentation] X線結晶構造から考察するDnmt1による維持メチル化機構2011
- Author(s)
  竹下浩平、末武勲、山下栄樹、菅倫寛、成田宏隆、中川敦史、田嶋正三
- Organizer
  第5回日本エヒジェネティクス研究会年会
- Place of Presentation
  KKR熊本
- Data Source
  KAKENHI-PROJECT-23770145
[Presentation] Dnmt1によるメチル化模様維持機構に関する構造生物学的研究2011
- Author(s)
  竹下浩平、末武勲、山下栄樹、菅倫寛、成田宏隆、中川敦史、田嶋正二
- Organizer
  第１１回日本蛋白質科学会年会
- Place of Presentation
  ホテル阪急エキスポパーク
- Data Source
  KAKENHI-PROJECT-23770145
[Presentation] Ｘ線結晶構造から見るDnmt1のエピジェネティックマーク継承のメカニズム2011
- Author(s)
  竹下浩平、末武勲、山下栄樹、菅倫寛、成田宏隆、中川敦史、田嶋正二
- Organizer
  第49回生物物理学会年会
- Place of Presentation
  兵庫県立大学書写キャンパス
- Data Source
  KAKENHI-PROJECT-23770145
[Presentation] Dnmt1のX線結晶構造から考察する維持メチル化機構2011
- Author(s)
  竹下浩平
- Organizer
  神経科学と構造生物学の融合J(大阪大学蛋白質研究所セミナー・包括脳ネットワーク研究会)
- Place of Presentation
  (岡崎コンファレンスセンター)
- Data Source
  KAKENHI-PROJECT-23770145
[Presentation] Structural insight into maintenance methylation by mouse DNA methyltransferase 12011
- Author(s)
  Takeshita K, Suetake, I., Yamashita, E., Suga, Narita, H., Nakagawa, A., Tajima S.
- Organizer
  International Union of Crystallography (IUCr)
- Place of Presentation
  Madrid Spain
- Data Source
  KAKENHI-PROJECT-23770145
[Presentation] X線結晶構造から見るDnmt1のエピジエネティックマーク継承のメカニズム2011
- Author(s)
  竹下浩平、末武勲、山下栄樹、菅倫寛、成田宏隆、中川敦史、田嶋正三
- Organizer
  第49回生物物理学会年会
- Place of Presentation
  兵庫県立大学書写キャンパス
- Data Source
  KAKENHI-PROJECT-23770145
[Presentation] Dnmt1のX線結晶構造から考察する維持メチル化機構2011
- Author(s)
  竹下浩平、末武勲、山下栄樹、菅倫寛、成田宏隆、中川敦史、田嶋正二
- Organizer
  第２回　神経科学と構造生物学の融合(招待講演)
- Place of Presentation
  岡崎コンファレンスセンター中会議室
- Data Source
  KAKENHI-PROJECT-23770145
[Presentation] Ｘ線結晶構造から考察するDnmt1による維持メチル化機構
- Author(s)
  竹下浩平、末武勲、山下栄樹、菅倫寛、成田宏隆、中川敦史、田嶋正二
- Organizer
  第５回日本エピジェネティクス研究会年会
- Place of Presentation
  KKRホテル熊本
- Data Source
  KAKENHI-PROJECT-23770145
[Presentation] Structural insight into maintenance methylation by mouse DNA methyltransferase 1
- Author(s)
  Takeshita, K., Suetake, I., Yamashita, E., Suga, M., Narita, H., Nakagawa, A., Tajima, S.
- Organizer
  International Union of Crystallography (IUCr)
- Place of Presentation
  Madrid Spain
- Data Source
  KAKENHI-PROJECT-23770145

1. 吉見一人 (50709813)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
2. YAMASHITA Taku (70398246)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. 中山亨 (80268523)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. 和氣駿之 (10793705)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. 田中良和 (20374225)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 山下哲 (70361186)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. 齋尾智英 (80740802)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. Yonezawa Yasushige (40248753)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. NAKAGAWA Atushi (20188890)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. OKAMURA Yasushi (80201987)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. ARAI Masayoshi (80311231)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 鷹野優 (30403017)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. 宇野公之 (00183020)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 辻野博文 (10707144)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 久野朗広 (60830122)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 高橋征司 (90343061)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. 戸澤譲 (90363267)

# of Collaborated Projects: 1 results

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18. 真下知士 (80397554)

# of Collaborated Projects: 1 results

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19. 石田紗恵子 (50777927)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 浜口祐 (00587876)

# of Collaborated Projects: 1 results

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21. 清水伸隆 (20450934)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 岡村孝司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 梅田健一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 末武勲

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takeshita Kohei 竹下 浩平

TAKESITA Kouhei 竹下 浩平

TAKESHITA Kohei 竹下 浩平

Research Projects

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Development of precise genome engineering methods using modiied CRISPR-Cas3

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植物特化代謝における超分子的代謝マシナリの形成：多元構造解析による統合的理解

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Molecular dissection of plant specialized metabolism machineries

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Development of novel gene editing methods based on the elucidation of the Type I CRISPR genome editing mechanisms

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Integrative Structural Biology Studies on the development for safe and efficient Cas3 genome editing toolsPrincipal Investigator

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Application to elucidate the function of targets for novel anti-tuberculosis drugs and to develop detection kits

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A Simulation Study on the Mechanism of Membrane Voltage Depended Protein VSOP

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Origination of antibiotic drugs for tuberculosis based on the structural analyses of novel target proteins

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Structural study of maintenance methylation by Dnmt1Principal Investigator

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[Book] DNA Methyltransferases - Role and Function, 「Domain Structure of the Dnmt1, Dnmt3a, and Dnmt3b DNA Methyltransferases」2022

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[Journal Article] Structural‐Functional Correlations between Unique N‐terminal Region and C‐terminal Conserved Motif in Short‐chain <i>cis</i>‐Prenyltransferase from Tomato2024

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[Journal Article] A large pocket structure surrounding the catalytic center in the BCG protein from Mycobacterium tuberculosis2024

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[Journal Article] Large-scale serosurveillance of COVID-19 in Japan: Acquisition of neutralizing antibodies for Delta but not for Omicron and requirement of booster vaccination to overcome the Omicron’s outbreak2022

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Takeshita Kohei 竹下浩平

TAKESITA Kouhei 竹下浩平

TAKESHITA Kohei 竹下浩平