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AZUMA Sadahiro  東 貞宏

ORCIDConnect your ORCID iD *help
Researcher Number 80348507
Affiliation (based on the past Project Information) *help 2015: 北里大学, 医学部, 助教
2011 – 2012: 北里大学, 医学部, 助教
2007 – 2008: Kitasato university, School of Medicine, Research Associate
2007: 北里大学, 医学部, 助教授
2003 – 2006: 北里大学, 医学部, 助手
Review Section/Research Field
Except Principal Investigator
Neurochemistry/Neuropharmacology / Neurochemistry/Neuropharmacology / Laboratory animal science / Biological Sciences
Keywords
Except Principal Investigator
SNAP-25 / 開口放出 / ストレス / SNAREタンパク質 / 神経伝達物質 / てんかん / ノックインマウス / プロテインキナーゼC / タンパク質リン酸化 / リン酸化 … More / non-goiter / rdw / IGF-1 / NGF / EGF / BDNF / 不安様行動 / ドーパミン / 情動異常 / 抗てんかん薬 / 行動異常 / ピロカルピンモデル / 遺伝子改変マウス / 脳波測定 / 不安用行動 / molecular chaperon / mutant Tg-ERp72 interaction / thyroid hormone / dopamine D_2-like receptor / ancreatic uroteome / congenital hypothyroidism / CNPase / ドーパミンD2受容体 / 海馬 / 大脳皮質 / 神経 / ERp72 / Tpo / thyroglobulin / 甲状腺機能低下症 / 小脳 / モデル動物 / クレチン症 / 脳 / NR2 / NR1 / NMDA recptor / ERストレス / アポトーシス / Tg-G2320R コンプレックス / 分子シャペロン / Tg-G2320R / goiter / 甲状腺機能低下症ラット / phospholipid / microdomain / exocytosis / neurotransmitter / growth factor / PI3キナーゼ / MAPキナーゼ / 神経伝達物資放出 / PIP5キナーゼ / PIP2 / 神経伝達物質放出 / EFG / 特異抗体 / リン脂質 / マイクロドメイン / 成長因子 / 活性化アストロサイト / モデルマウス / 不安障害 / モノアミン / ピロカルピン / シナプトゾーム / PKC / シナプス前世制御 / アドレナリン / シナプス前性制御 / レセプター / キナーゼ / アストロサイト / 化学伝達物質 / グリア細胞 Less
  • Research Projects

    (7 results)
  • Research Products

    (12 results)
  • Co-Researchers

    (14 People)
  •  Studies on regulatory mechanisms of brain function by protein kinase C-mediated SNAP-25 phosphorylation.

    • Principal Investigator
      TAKAHASHI MASAMI
    • Project Period (FY)
      2012 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Kitasato University
  •  Elucidation of neuronal basis of anxiety behavior

    • Principal Investigator
      TAKAHASHI Masami
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Kitasato University
  •  Roles of protein phosphorylation in regulatory mechanism of presynaptic functions.

    • Principal Investigator
      TAKAHASHI Masami
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Kitasato University
  •  Functional roles of PKC-dependent SNAP-25 phosphorylation in brain function

    • Principal Investigator
      TAKAHASHI Masami
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Kitasato University
  •  Characteristic analysis and therapeutic development in rdw rats with congenital hypothyroidism

    • Principal Investigator
      FURUDATE Sen-ichi
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory animal science
    • Research Institution
      Kitasato University
  •  グリア細胞における化学伝達物質およびそのレセプターの制御機構の解明

    • Principal Investigator
      TAKAHASHI Masami
    • Project Period (FY)
      2003 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kitasato University
  •  Regulatory mechanisms of neurotransmitter release by cytokine and growth factors.

    • Principal Investigator
      TAKAHASHI Masami
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Kitasato University

All 2011 2009 2008 2007 2006

All Journal Article Presentation

  • [Journal Article] A Single Amino Acid Mutation in SNAP-25 Induces Anxiety-Related Behavior in Mouse2011

    • Author(s)
      Kataoka M, Yamamori S, Suzuki E, Watanabe S, Sato T, Miyaoka H, Azuma S, Ikegami S, Kuwahara R, Suzuki-Migishima R, Nakahara Y, Nihonmatsu I, Inokuchi K, Katoh-Fukui Y, Yokoyama M, Takahashi
    • Journal Title

      PLoS ONE

      Volume: 6

    • NAID

      120007113683

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23650193
  • [Journal Article] A Single Amino Acid Mutation in SNAP-25 Induces Anxiety-Related Behavior in Mouse2011

    • Author(s)
      Kataoka M, Yamamori S, Suzuki E, Watanabe S, Sato T, Miyaoka H, Azuma S, Ikegami S, Kuwahara R, Suzuki-Migishima R, Nakahara Y, Nihonmatsu I, Inokuchi K, Katoh-Fukui Y, Yokoyama M, Takahashi M
    • Journal Title

      PLoS ONE

      Volume: 6(9)

    • NAID

      120007113683

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23650193
  • [Journal Article] A Single Amino Acid Mutation in SNAP-25 Induces Anxiety-Related Behavior in Mouse2011

    • Author(s)
      Kataoka M, Yamamori S, Suzuki E, Watanabe S, Sato T, Miyaoka H, Azuma S, Ikegami S, Kuwahara R, Suzuki-Migishima R, Nakahara Y, Nihonmatsu I, Inokuchi K, Katoh-Fukui Y, Yokoyama M, Takahashi M
    • Journal Title

      PLoS ONE

      Volume: 6

    • NAID

      120007113683

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21300141
  • [Presentation] SNAP-25変異マウスの行動異常に対する各種向精神薬の効果2009

    • Author(s)
      鈴木映二、宮岡等、東貞宏、渡辺滋、片岡正和、高橋正身山森早織小久保宏俊、大塚信太朗
    • Organizer
      第20回臨床精神神経薬理学会・第40回日本神経精神薬理学会合同年会
    • Place of Presentation
      仙台
    • Year and Date
      2009-09-16
    • Data Source
      KAKENHI-PROJECT-21300141
  • [Presentation] Neuropeptide Y is increased in the brain of Snap-25 mutant mice. Neuroscience 20082008

    • Author(s)
      山森早織、内田達也、東貞宏、片岡正和、高橋正身
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-18300127
  • [Presentation] Short- and long-term synaptic plasticity in area CAl pf the hippo-campus in adult rdw/rdw rats with congenital hypothyroidism campus in adult rdw/rdw rats with congenital hypothyroidism2007

    • Author(s)
      Oh-Nishi, A., Suzuki, N., Azuma, S., Ishihara, Y., Katada, R., Furudate, S
    • Organizer
      The 32th of The Japan for Comparative Endocrinology
    • Place of Presentation
      Nikko
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17500289
  • [Presentation] Short-and long-term synaptic plasticity in area CA1 pf the hippo-campus in adult rdw/rdw rats with congenital hypothyroidism2007

    • Author(s)
      Oh-Nishi A, Suzuki N, Azuma S, Ishihara Y, Katada R & Furudate S
    • Organizer
      第32回比較内分泌学会
    • Place of Presentation
      栃木県日光市
    • Data Source
      KAKENHI-PROJECT-17500289
  • [Presentation] Short- and long-term synaptic plasticity in area CAl pf the hippo-campus in adult rdw/rdw rats with congenital hypothyroidism campus in adult rdw/rdw rats with congenital hypoth yroidism2007

    • Author(s)
      Oh-Nishi A, Suzuki N, Azuma S, Ishihara Y, Katada R, Furudate S
    • Organizer
      第32回日本比較内分泌学会
    • Place of Presentation
      栃木県日光市
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17500289
  • [Presentation] SNAP-25変異ノックインマウス脳における神経伝達物質に関する研究2006

    • Author(s)
      鈴木映二、佐藤拓、朝倉哲也、山森早織、東貞宏、渡辺滋、横山正宗、宮岡等、片岡正和、高橋正身
    • Organizer
      第49回日本神経化学会大会(第28回日本生物学的精神医学会、第36回日本神経精神薬理学会)
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-18300127
  • [Presentation] Reactive astrogliosis in hippocampus of SNAP-25 mutant mouse2006

    • Author(s)
      山森早織、勝又修、山科正平、朝倉哲也、佐藤拓、鈴木映二、渡辺滋、宮岡等、東貞宏、片岡正和、高橋正身
    • Organizer
      第49回日本神経化学会大会(第28回日本生物学的精神医学会、第36回日本神経精神薬理学会)
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-18300127
  • [Presentation] Phosphorylation of SNAP-25, an essential protein for neurotransmitter release, is essential for the emotional homeostasis in mouse. 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress2006

    • Author(s)
      M. Kataoka, S. Yamamori, T. Sato, E. Suzuki, S. Watanabe, H. Miyaoka, S. Ikegami, R. Kuwahara, R. Suzuki-Migishima, Y. Nakahara, K. Inokuchi, Y. Kato-Fukui, S. Azuma, M. Yokoyama, and M. Takahashi.
    • Organizer
      第79回日本生化学会大会/第29回日本分子生物学会大会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-18300127
  • [Presentation] A single amino acid substitution of SNAP-25 at PKC-dependent phosphorylation site markedly increases the stress-vulnerability in mice2006

    • Author(s)
      M. Kataoka, S. Yamamori, T. Sato, E. Suzuki, S. Watanabe, H. Miyaoka, S. Ikegami, R. Kuwahara, R. Suzuki- Migishima, Y. Nakahara, I. Nihonmatsu, K. Inokuchi, Y. Kato-Fukui, S. Azuma, M. Yokoyama, and M. Takahashi
    • Organizer
      29th Japan Neuroscience Meeting Satellite Symposium. Mouse genetical manipulations as tools for understanding brain function
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-18300127
  • 1.  TAKAHASHI Masami (10318826)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 9 results
  • 2.  ITAKURA Makoto (30398581)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 3.  KATAOKA Masakazu (90332676)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 7 results
  • 4.  MIYAOKA Hitoshi (40209862)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 4 results
  • 5.  YAMAMORI Saori (30464803)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 4 results
  • 6.  TAKAGAKI Yotaro (50281324)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  NAKAMURA Kazuo (40189030)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  FURUDATE Sen-ichi (80095512)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 9.  SAKAI Yasuhiiro (00050625)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  SUZUKI Nobuyuki (10050650)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 11.  OH-ISHI Masamichi (40233027)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  OKADA Daisuke (10211806)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  阿部 輝雄 (50010103)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  WATANABE Shigeru
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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