Yoshimaru Tetsuro 吉丸哲郎

… Alternative Names

YOSHIMARU Tetsuro 吉丸哲郎

吉丸哲郎ヨシマルテツロウ

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Researcher Number	80424729
Other IDs
Affiliation (Current)	2025: 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所創薬デザイン研究センター, 主任研究員 2025: 日本大学, 医学部, 研究員 2025: 徳島大学, 先端酵素学研究所, 准教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 徳島大学, 先端酵素学研究所, 准教授 2019: 徳島大学, 先端酵素学研究所(プロテオ), 准教授 2016 – 2018: 徳島大学, 先端酵素学研究所(プロテオ), 講師 2015: 徳島大学, 疾患プロテオゲノム研究センター, 講師 2014: 徳島大学, 疾患プロテオゲノム研究センター, 助教 … More 2012: 徳島大学, 疾患プロテオゲノム研究センター, 特任助教 2009: 日大, 医学部, 研究員 2007 – 2008: Nihon University, 医学部, 研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 55010:General surgery and pediatric surgery-related / General surgery / General medical chemistry / 膠原病・アレルギー・感染症内科学 Except Principal Investigator Pathological medical chemistry / Tumor biology and related fields / Tumor diagnosis
Keywords	Principal Investigator 活性酸素 / がん抑制因子 / ステープル化ペプチド / ペプチド創薬 / トラスツズマブ耐性 / HER2陽性乳がん / HER2陽性乳癌 / ミトコンドリア / 薬剤耐性 / 乳がん … More / 乳癌 / トラスツズマブ / 足場タンパク質 / BIG3-PHB2複合体 / 活性酸素種 / 治療耐性 / アロマターゼ阻害剤 / 内分泌療法耐性乳がん / クロストーク / エストロゲン受容体 / 内分泌療法耐性乳癌 / 気管支喘息 / 好中球 / FcεRI … More Except Principal Investigator tumor suppressor / breast cancer / ゲノム / 癌 / 創薬 / HER2 / がん特異的発現亢進因子 / がん抑制因子 / ミトコンドリア / 乳がん / タンパク相互作用阻害 / multistep carcinogenesis / drug discovery / プロテオーム / タンパク質 / 生体機能利用 / mitochondrial regulation / oncogenic signaling / dephosphorylation / phosphorylation / estrogen signaling / ゲノム創薬 / ホルモン療法耐性 / システムバイオロジー / エストロゲン / 乳癌 / ホルモン / 蛋白質 / 変異 / TNBC / がんゲノム / 次世代シーケンサー Less

A therapeutic strategy to overcome drug resistance in HER2-positive breast cancer targeting the BIG3-PHB2 complexesPrincipal Investigator
- Principal Investigator
  
  吉丸哲郎
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  The University of Tokushima
BIG3-PHB2 complexes is required for the acquired trastuzumab-resistance of HER2-positive breast cancerPrincipal Investigator
- Principal Investigator
  
  YOSHIMARU Tetsuro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  The University of Tokushima
Acquired resistance to hormone therapy of breast cancer by mitochondrial reactive oxygen speciesPrincipal Investigator
- Principal Investigator
  
  YOSHIMARU Tetsuro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  The University of Tokushima
Drug discovery in breast cancer utilizing reactivation of tumor suppressors
- Principal Investigator
  
  KATAGIRI Toyomasa
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Tumor biology and related fields
- Research Institution
  The University of Tokushima
Clarification of novel pathophysiological roles of BIG3 in breast cancer cells
- Principal Investigator
  
  KATAGIRI Toyomasa
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokushima
Therapeutic advances in BIG3-PHB2 inhibition targeting the cross-talk between estrogen and growth factors in breast cancerPrincipal Investigator
- Principal Investigator
  
  YOSHIMARU Tetsuro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  The University of Tokushima
Drug development and biological function study of novel estrogen receptor activity modulator BIG3 protein
- Principal Investigator
  
  KATAGIRI Toyomasa
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokushima
次世代シークエンサーによる新規乳がん関連遺伝子の探索
- Principal Investigator
  
  清谷一馬
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor diagnosis
- Research Institution
  The University of Tokushima
ミトコンドリア由来活性酸素を標的とした免疫難病治療の新戦略Principal Investigator
- Principal Investigator
  
  吉丸哲郎
- Project Period (FY)
  2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Nihon University
Extracellular superoxide released from neutrophil is a critical determinant of severity of asthmatic symptoms : Role of Fcε I in asthmatic patient.Principal Investigator
- Principal Investigator
  
  YOSHIMARU Tetsuro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Nihon University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2008 Other

All Journal Article Presentation Book

[Book] Precision Medicine2018
- Author(s)
  永井良三、加藤益弘、山崎力、田中俊博、宮川清、岡田尚巳、金田安史、長尾知生子、岩部美紀、山西芳裕、小出大介、辻真博、益尾憲、小林哲大、藤本臣哉、山本雄介、吉丸哲郎、片桐豊雅、野村渉、矢野恒夫、他8名
- Total Pages
  126
- Publisher
  北隆館
- ISBN
- Data Source
  KAKENHI-PROJECT-17K10551
[Journal Article] The survival and proliferation of osteosarcoma cells are dependent on the mitochondrial BIG3‐PHB2 complex formation2021
- Author(s)
  Toki Shunichi、Yoshimaru Tetsuro、Matsushita Yosuke、Aihara Hitoshi、Ono Masaya、Tsuneyama Koichi、Sairyo Koichi、Katagiri Toyomasa
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 10 Pages: 4208-4219
- DOI
  10.1111/cas.15099
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07643, KAKENHI-PROJECT-20H00543, KAKENHI-PROJECT-20K08958, KAKENHI-PROJECT-20K09435
[Journal Article] Functional genomics for breast cancer drug target discovery.2021
- Author(s)
  Yoshimaru T, Nakamura Y, Katagiri T.
- Journal Title
  
  J Hum Genet.
  
  Volume: 66 Issue: 9 Pages: 927-935
- DOI
  10.1038/s10038-021-00962-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00543, KAKENHI-PROJECT-20K08958
[Journal Article] 分子内架橋型BIG3-PHB2相互作用ペプチドによるホルモン依存性乳がんの新規治療法の開発2019
- Author(s)
  吉丸哲郎、片桐豊雅
- Journal Title
  
  最新医学
  
  Volume: 74 Pages: 115-121
- Data Source
  KAKENHI-PROJECT-17K10551
[Journal Article] Biophysical characterization of the breast cancer-related BIG3-PHB2 interaction: Effect of non-conserved loop region of BIG3 on the structure and the interaction.2019
- Author(s)
  Chigira T, Nagatoishi S, Takeda H, Yoshimaru T, Katagiri T, Tsumoto K.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 518 Issue: 1 Pages: 183-189
- DOI
  10.1016/j.bbrc.2019.08.028
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-17H06419, KAKENHI-PLANNED-19H05766, KAKENHI-PROJECT-18H02082, KAKENHI-PROJECT-17K10551
[Journal Article] A DDX31/mutant-p53/EGFR axis promotes multistep progression of muscle invasive bladder cancer2018
- Author(s)
  Daizumoto Kei、Yoshimaru Tetsuro、Matsushita Yosuke、Fukawa Tomoya、Uehara Hisaori、Ono Masaya、Komatsu Masato、Kanayama Hiro-omi、Katagiri Toyomasa
- Journal Title
  
  Cancer Research
  
  Volume: － Issue: 9 Pages: 2528-2528
- DOI
  10.1158/0008-5472.can-17-2528
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01575, KAKENHI-PLANNED-17H06419, KAKENHI-PROJECT-16H05153, KAKENHI-PROJECT-17K10551, KAKENHI-PROJECT-18K09136, KAKENHI-PROJECT-17K19601
[Journal Article] Frequent downregulation of LRRC26 by epigenetic alterations is involved in the malignant progression of triple-negative breast cancer2018
- Author(s)
  Miyagawa Yoshimasa、Matsushita Yosuke、Suzuki Hiromu、Komatsu Masato、Yoshimaru Tetsuro、Kimura Ryuichiro、Yanai Ayako、Honda Junko、Tangoku Akira、Sasa Mitsunori、Miyoshi Yasuo、Katagiri Toyomasa
- Journal Title
  
  International Journal of Oncology
  
  Volume: － Pages: 4301-4301
- DOI
  10.3892/ijo.2018.4301
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01575, KAKENHI-PLANNED-17H06419, KAKENHI-PROJECT-16H05153, KAKENHI-PROJECT-16K19052, KAKENHI-PROJECT-17K10551, KAKENHI-PROJECT-17K19601
[Journal Article] A-kinase anchoring protein BIG3 coordinates oestrogen signaling in breast cancer cells2017
- Author(s)
  〇Yoshimaru T, Ono M, Bando Y, Chen YA, Mizuguchi K, Shima H, Komatsu M, Imoto I, Izumi K, Honda J, Miyoshi Y, Sasa M, Katagiri T*
- Journal Title
  
  Nature Communications
  
  Volume: 印刷中
- NAID
  120006535065
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H05153
[Journal Article] Protein kinase A inhibition facilitates the antitumor activity of xanthohumol, a valosin-containing protein inhibitor2017
- Author(s)
  Y. Shikata Y, T. Yoshimaru, M. Komatsu, H. Katoh, R. Sato, S. Kanagaki, Y. Okazaki, S. Toyokuni, E. Tashiro, S. Ishikawa, T. Katagiri, M. Imoto,
- Journal Title
  
  Cancer Science
  
  Volume: 108 Issue: 4 Pages: 785-794
- DOI
  10.1111/cas.13175
- NAID
  120006535004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-24108008, KAKENHI-PROJECT-15H03116, KAKENHI-PROJECT-26350974, KAKENHI-PROJECT-26461948, KAKENHI-PROJECT-15K08398, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16H02481
[Journal Article] 包括的ゲノム解析を通じた乳癌の発症・進展機構解明の現状と展望2017
- Author(s)
  松下洋輔、吉丸哲郎、片桐豊雅
- Journal Title
  
  日本臨牀
  
  Volume: 75 Pages: 155-160
- Data Source
  KAKENHI-PROJECT-26461948
[Journal Article] A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells.2017
- Author(s)
  Yoshimaru T, Ono M, Bando Y, Chen YA, Mizuguchi K, Shima H, Komatsu M, Imoto I, Izumi K, Honda J, Miyoshi Y, Sasa M, Katagiri T
- Journal Title
  
  Nature Communications
  
  Volume: 印刷中 Issue: 1 Pages: 15427-15427
- DOI
  10.1038/ncomms15427
- NAID
  120006535065
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461948, KAKENHI-PROJECT-17K07187, KAKENHI-PUBLICLY-16H01575, KAKENHI-PROJECT-16H05153
[Journal Article] Stapled BIG3 helical peptide ERAP potentiates antitumour activity for breast cancer therapeutics.2017
- Author(s)
  Yoshimaru T, Aihara K, Komatsu M, Matsushita Y, Okazaki Y, Toyokuni S, Honda J, Sasa M, Miyoshi Y, Otaka A, Katagiri T
- Journal Title
  
  Scientific Reports
  
  Volume: 印刷中 Issue: 1 Pages: 1821-1821
- DOI
  10.1038/s41598-017-01951-6
- NAID
  120006535017
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461948, KAKENHI-PROJECT-17K19492, KAKENHI-PUBLICLY-16H01575, KAKENHI-PROJECT-16H02611, KAKENHI-PROJECT-16H05153
[Journal Article] Stapled BIG3 helical peptide ERAP extends potent antitumor activity for breast cancer therapeutics2017
- Author(s)
  Yoshimaru T*, Aihara K, Komatsu M, Matsushita Y, Okazaki Y, Toyokuni S, Honda J, Sasa M, Miyoshi Y, Otaka A, Katagiri T*
- Journal Title
  
  Scientific Reports
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H05153
[Journal Article] 包括的ゲノム解析を通じたトリプルネガティブ乳癌の分子特性2016
- Author(s)
  吉丸哲郎、松下洋輔、片桐豊雅
- Journal Title
  
  乳癌の臨床
  
  Volume: 31 Pages: 377-385
- Data Source
  KAKENHI-PROJECT-26461948
[Journal Article] Therapeutic advances in BIG3-PHB2 inhibition targeting the crosstalk between estrogen and growth factors in breast cancer2015
- Author(s)
  Yoshimaru T, Komatsu M, Miyoshi Y, Honda J, Sasa M, Katagiri T
- Journal Title
  
  Cancer Sci
  
  Volume: in press Pages: 12654-12654
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461948
[Journal Article] BIG3 inhibit the estrogen-dependent nuclear translocation of PHB2 via multiple Karyopherin-alpha proteins in breast cancer cells.2015
- Author(s)
  Kim NH, Yoshimaru T, Chen YA, Matsuo T, Komatsu M, Miyoshi Y, Tanaka E, Sasa M, Katagiri T
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 6 Pages: e0127707-e0127707
- DOI
  10.1371/journal.pone.0127707
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461948, KAKENHI-PROJECT-25430186, KAKENHI-PROJECT-25293079
[Journal Article] Therapeutic advances in BIG3-PHB2 inhibition targeting the crosstalk between estrogen and growth factors in breast cancer.2015
- Author(s)
  Yoshimaru T, Komatsu M, Miyoshi Y, Honda J, Sasa M, Katagiri T
- Journal Title
  
  Cancer Science
  
  Volume: 106 Issue: 5 Pages: 550-558
- DOI
  10.1111/cas.12654
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461948, KAKENHI-PROJECT-25293079
[Journal Article] Early growth response 4 is involved in cell proliferation of small cell lung cancer through transcriptional activation of its downstream genes2014
- Author(s)
  Matsuo T, Dat le T, Komatsu M, Yoshimaru T, Daizumoto K, Sone S, Nishioka Y, Katagiri T
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 11 Pages: e113606-e113606
- DOI
  10.1371/journal.pone.0113606
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390210, KAKENHI-PUBLICLY-25134712, KAKENHI-PROJECT-25293079, KAKENHI-PROJECT-26461948, KAKENHI-PROJECT-26670418, KAKENHI-PROJECT-26860212
[Journal Article] Xanthohumol suppresses oestrogen-signalling in breast cancer through the specific inhibition of BIG3-PHB2 interaction.2014
- Author(s)
  Yoshimaru T, Komatsu M, Tashiro E, Imoto M, Osada H, Miyoshi M, Honda J, Sasa M, and Katagiri T
- Journal Title
  
  Scientific Report
  
  Volume: 4 Issue: 1 Pages: 7335-7335
- DOI
  10.1038/srep07355
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23102006, KAKENHI-PUBLICLY-25134712, KAKENHI-PROJECT-25293079, KAKENHI-PROJECT-26350974, KAKENHI-PROJECT-26461948, KAKENHI-PROJECT-26860212, KAKENHI-PROJECT-221S0001
[Journal Article] Involvement of B3GALNT2 overexpression in the cell growth of breast cancer.2014
- Author(s)
  Matsuo T, Komatsu M, Yoshimaru T, Kiyotani K, Miyoshi Y, Sasa M, Katagiri T.
- Journal Title
  
  International Journal of Oncology
  
  Volume: 44 Issue: 2 Pages: 427-434
- DOI
  10.3892/ijo.2013.2187
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293079
[Journal Article] Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (BIG3) is predicted to interact with its partner through an ARM-type α-helical structure2014
- Author(s)
  Mizuguchi K., Chen Y. A., Murakami Y., Ahmad S., Yoshimaru T., Katagri T.
- Journal Title
  
  BMC Res Notes
  
  Volume: 7 Issue: 1 Pages: 435-435
- DOI
  10.1186/1756-0500-7-435
- NAID
  120006864075
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25430186, KAKENHI-PROJECT-26461948, KAKENHI-PROJECT-26870045
[Journal Article] Targeting BIG3-PHB2 interaction to overcome tamoxifen resistance in breast cancer cells2013
- Author(s)
  T. Yoshimaru, M. Komatsu, T. Matsuo, Y.-A. Chen, Y. Murakami, K. Mizuguchi, E. Mizohata, T. Inoue, M. Akiyama, R. Yamaguchi, S. Imoto, S. Miyano, Y. Miyoshi, M. Sasa, Y. Nakamura, and T. Katagiri
- Journal Title
  
  Nature Communications
  
  Volume: 4 Issue: 1 Pages: 2433-2433
- DOI
  10.1038/ncomms3443
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-24109017, KAKENHI-PUBLICLY-25134712, KAKENHI-PROJECT-25293079, KAKENHI-PROJECT-25430186
[Presentation] Targeting BIG3-PHB2 interaction overcomes trastuzumab-resistance in patients with HER2-positive breast cancer2023
- Author(s)
  吉丸哲郎，松下洋輔，笹三徳，三好康雄，片桐豊雅
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K27661
[Presentation] BIG3-PHB2複合体を標的としたHER2陽性乳がんの薬剤耐性を克服する分子内架橋型阻害ペプチドstERAPの開発2023
- Author(s)
  吉丸哲郎，松下洋輔，片桐豊雅
- Organizer
  第27回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-23K27661
[Presentation] 胞膜BIG3-PHB2複合体がHER2陽性乳癌のトラスツズマブ耐性獲得に必須である2022
- Author(s)
  吉丸哲郎、松下洋輔、笹三徳、三好康雄、片桐豊雅
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K08958
[Presentation] トラスツズマブ耐性HER2陽性乳がんの克服に向けたBIG3-PHB2相互作用を標的とした持続型阻害ペプチドの開発2022
- Author(s)
  吉丸哲郎、松下洋輔、片桐豊雅
- Organizer
  第26回日本がん分子標的治療学会
- Data Source
  KAKENHI-PROJECT-20K08958
[Presentation] The plasma membrane BIG3-PHB2 complex contributes to the acquisition of trastuzumab-resistance in HER2-positive breast cancer.2022
- Author(s)
  Yoshimaru T., Matsushita Y., Kosako H., Sasa M., Miyoshi Y., Katagiri T.
- Organizer
  The 17th International Symposium of the Institute Network for Biomedical Sciences
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08958
[Presentation] トラスツズマブ耐性HER2陽性乳がんに対するBIG3-PHB2相互作用の標的治療薬としての可能性2021
- Author(s)
  吉丸哲郎, 松下洋輔, 片桐豊雅
- Organizer
  第25回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08958
[Presentation] HER2陽性乳癌のトラスツズマブ耐性獲得に対するBIG3-PHB2複合体の病態生理学的役割2021
- Author(s)
  吉丸哲郎, 松下洋輔, 笹三徳, 三好康雄, 片桐豊雅
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K08958
[Presentation] BIG3 phosphatase inactivates tumor suppressor PHB2 via tis dephosphorylation to contribute to the breast carcinogenesis2020
- Author(s)
  Tetsuro Yoshimaru, Yosuke Matsushita, Sasa Mitsunori, Miyoshi Yasuo and Toyomasa Katagiri
- Organizer
  The 14th International Conference on Protein Phosphatase
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08958
[Presentation] BIG3-PHB2複合体の形成が，HER2陽性乳癌のトラスツズマブ耐性獲得を誘導する2020
- Author(s)
  吉丸哲郎, 松下洋輔, 尾野雅哉, 笹三徳, 三好康雄, 片桐豊雅
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K08958
[Presentation] BIG3-PHB2標的治療薬によるトラスツズマブ耐性HER2陽性乳がんの克服2020
- Author(s)
  吉丸哲郎, 松下洋輔, 片桐豊雅
- Organizer
  第24回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08958
[Presentation] PHB2 inactivation by AKAP-BIG3 is required for progression of HER2-overexpressing breast cancer.2019
- Author(s)
  Tetsuro Yoshimaru, Yosuke Matsushita, Mitsunori Sasa, Yasuo Miyoshi, Toyomasa Katagiri
- Organizer
  Annual meeting of American Association for Cancer Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10551
[Presentation] BIG3複合体によるがん抑制因子PHB2の不活性化を介したトラスツズマブ耐性乳がんの増殖機構と新規治療法2019
- Author(s)
  吉丸哲郎、松下洋輔、片桐豊雅
- Organizer
  第23回日本がん分子標的治療学会
- Data Source
  KAKENHI-PROJECT-17K10551
[Presentation] トラスツズマブ耐性乳がんに関連したBIG3-PHB2相互作用標的治療薬の開発2019
- Author(s)
  吉丸哲郎、松下洋輔、笹三徳、三好康雄、片桐豊雅
- Organizer
  第78回日本癌学会・学術総会
- Data Source
  KAKENHI-PROJECT-17K10551
[Presentation] DDX31 cooperates with mutant p53 and EGFR to promote the multistep progression of invasive bladder cancer2018
- Author(s)
  Toyomasa Katagiri, Kei Daizumoto, Tetsuro Yoshimaru, Yosuke Matsushita, Tomoya Fukawa, Ono Masaya and Hiro-omi Kanayama
- Organizer
  American Association For Cancer Research ANNUAL MEETING 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19601
[Presentation] Overcoming trastuzumab resistance in HER2-overexpressing breast cancer by utilizing PHB2, a tumor suppressor of multiple resistance pathways2018
- Author(s)
  Tetsuro Yoshimaru, Yosuke Matsushita, Sasa Mitsunori, Miyoshi Yasuo and Toyomasa Katagiri
- Organizer
  American Association for Cancer Research ANNUAL MEETING 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05153
[Presentation] 新規Aキナーゼアンカータンパク質BIG3による抑制因子PHB2の制御はHER2乳癌細胞増殖に必須である2018
- Author(s)
  吉丸哲郎，松下洋輔，片桐豊雅
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K19601
[Presentation] BIG3-PKA-PP1Cα複合体による癌抑制因子PHB2不活性化を介したトラスツズマブ耐性乳癌増殖機構と新規治療法開発2018
- Author(s)
  Tetsuro Yoshimaru, Yosuke Matsushita, Mitsunori Sasa, Yasuo Miyoshi, Toyomasa Katagiri
- Organizer
  第77回日本癌学会・学術総会
- Data Source
  KAKENHI-PROJECT-17K10551
[Presentation] DDX31 cooperates with mutant p53 and EGFR to promote the multistep progression of invasive bladder cancer2018
- Author(s)
  Toyomasa Katagiri, Kei Daizumoto, Tetsuro Yoshimaru, Yosuke Matsushita, Tomoya Fukawa, Ono Masaya and Hiro-omi Kanayama
- Organizer
  American Association For Cancer Research ANNUAL MEETING 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05153
[Presentation] BIG3-PKA-PP1Cα複合体による癌抑制因子PHB2不活性化を介したトラスツズマブ耐性乳癌増殖機構と新規治療法開発2018
- Author(s)
  吉丸哲郎, 松下洋輔, 笹三徳, 三好康雄, 片桐豊雅
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H05153
[Presentation] Overcoming trastuzumab resistance in HER2-overexpressing breast cancer by utilizing PHB2, a tumor suppressor of multiple resistance pathways,2018
- Author(s)
  Tetsuro Yoshimaru, Yosuke Matsushita, Mitsunori Sasa, Yasuo Miyoshi, Toyomasa Katagiri
- Organizer
  American Association for Cancer Research ANNUAL MEETING 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10551
[Presentation] 新規Aキナーゼアンカータンパク質BIG3による抑制因子PHB2の制御はHER2乳癌細胞増殖に必須である2018
- Author(s)
  吉丸哲郎，松下洋輔，片桐豊雅
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16H05153
[Presentation] BIG3-PKA-PP1Cα複合体による癌抑制因子PHB2不活性化を介したトラスツズマブ耐性乳癌増殖機構と新規治療法開発2018
- Author(s)
  吉丸哲郎, 松下洋輔, 笹三徳, 三好康雄, 片桐豊雅
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K19601
[Presentation] 新規Aキナーゼアンカータンパク質BIG3による抑制因子PHB2の制御がHER2乳癌細胞の増殖に必須である2018
- Author(s)
  吉丸哲郎、松下洋輔、片桐豊雅
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K10551
[Presentation] Overcoming trastuzumab resistance in HER2-overexpressing breast cancer by utilizing PHB2, a tumor suppressor of multiple resistance pathways2018
- Author(s)
  Tetsuro Yoshimaru, Yosuke Matsushita, Sasa Mitsunori, Miyoshi Yasuo and Toyomasa Katagir
- Organizer
  American Association for Cancer Research ANNUAL MEETING 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19601
[Presentation] ホルモン陽性乳がんに対する新規治療法の開発2017
- Author(s)
  吉丸哲郎、片桐豊雅
- Organizer
  第78回徳島乳腺研究会
- Data Source
  KAKENHI-PROJECT-17K10551
[Presentation] A novel A-kinase anchoring protein BIG3 coordinates estrogen signaling in breast cancer cells2017
- Author(s)
  Tetsuro Yoshimaru, Masaya Ona, Yosuke Matsushita, Masato Komatsu, Mitsunori Sasa, Yasuo Miyoshi, Toyomasa Katagiri
- Organizer
  第76回日本癌学会・学術総会
- Data Source
  KAKENHI-PROJECT-17K10551
[Presentation] 分子内架橋型BIG3-PHB2相互作用阻害ペプチドERAPによるホルモン依存性乳がん新規治療法の開発2017
- Author(s)
  吉丸哲郎、松下洋輔、片桐豊雅
- Organizer
  第21回日本がん分子標的治療学会
- Data Source
  KAKENHI-PROJECT-17K10551
[Presentation] Development of stapled peptides targeting BIG3-PHB2 interaction in breast cancer cells2016
- Author(s)
  粟飯原圭佑, 吉丸哲郎, 小松正人, 重永章, 片桐豊雅, 大髙章
- Organizer
  第53回ペプチド討論会/日本ペプチド学会
- Place of Presentation
  京都テルサ　京都府京都市
- Year and Date
  2016-10-26
- Data Source
  KAKENHI-PROJECT-16H05153
[Presentation] Development of chemically modified peptide inhibitor ERAP targeting BIG3-PHB2 complex on hormone-resistant breast cancer2016
- Author(s)
  Tetsuro Yoshimaru, Toyomasa Katagiri
- Organizer
  2nd International Symposium on Molecular Medicine in Tokushima University
- Place of Presentation
  徳島大学大塚講堂（徳島県徳島市）
- Year and Date
  2016-11-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461948
[Presentation] ホルモン療法耐性乳がん治療を目的とした分子内架橋型BIG3-PHB2相互作用阻害ペプチドの開発2016
- Author(s)
  吉丸哲郎、小松正人、片桐豊雅
- Organizer
  第20回日本がん分子標的治療学会
- Place of Presentation
  別府コンベンションセンター（大分県別府市）
- Year and Date
  2016-05-30
- Data Source
  KAKENHI-PROJECT-26461948
[Presentation] 内分泌療法耐性乳がんに対するBIG3-PHB2相互作用阻害ペプチドの開発2016
- Author(s)
  吉丸哲郎, 松下洋輔, 小松正人, 岡崎泰昌, 豊國伸哉, 笹三徳, 三好康雄, 片桐豊雅
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜　神奈川県横浜市
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16H05153
[Presentation] Development of chemically modified peptide inhibitor ERAP targeting BIG3-PHB2 complex on hormone-resistant breast cancer,2016
- Author(s)
  Tetsuro Yoshimaru and Toyomasa Katagiri
- Organizer
  2nd International Symposium of Molecular Medicine in Tokushima University
- Place of Presentation
  徳島大学　徳島県徳島市
- Year and Date
  2016-11-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05153
[Presentation] A novel A-kinase anchoring protein, BIG3, coordinates estrogen signalling in breast cancer cells2016
- Author(s)
  Tetsuro Yoshimaru, Masaya Ono, Kenji Mizuguchi, Yasuo Miyoshi, Mitsunori Sasa, Toyomasa Katagiri
- Organizer
  The 12th International Conference on Protein Phosphatase
- Place of Presentation
  近畿大学東大阪キャンパス 11月ホール（大阪府東大阪市）
- Year and Date
  2016-11-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461948
[Presentation] BIG3-PHB2相互作用阻害ペプチドstERAPによる内分泌治療耐性乳がん治療薬の開発2016
- Author(s)
  吉丸哲郎、片桐豊雅
- Organizer
  平成27年度革新的特色研究シンポジウム　徳大薬学部創薬シーズの整備と蔵本ネットワークを基盤としたアカデミア創薬研究
- Place of Presentation
  徳島大学薬学部第一講義室（徳島県徳島市）
- Year and Date
  2016-03-16
- Data Source
  KAKENHI-PROJECT-26461948
[Presentation] BIG3-PHB2相互作用を標的とした前立腺がん治療法の開発の可能性2016
- Author(s)
  瀧亮祐, 吉丸哲郎, 大豆本圭, 松下洋輔, 木村竜一朗, 尾野雅哉, 片桐豊雅
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜　神奈川県横浜市
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16H05153
[Presentation] A novel A-kinase anchoring protein BIG3, coordinates estrogen signalling in breast cancer cells2016
- Author(s)
  Tetsuro Yoshimaru, Ono Masaya, Mizuguchi Kenji, Miyoshi Yasuo, Mitsunori Sasa and Toyomasa Katagiri
- Organizer
  The 12th International Conference on Protein Phosphatase
- Place of Presentation
  近畿大学　大阪府東大阪市
- Year and Date
  2016-10-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05153
[Presentation] Development of chemically modified peptide inhibitor ERAP targeting BIG3-PHB2 complex on hormone-resistant breast cancer2016
- Author(s)
  Tetsuro Yoshimaru, Yosuke Matsushita, Masato Komatsu, Yasumasa Okazaki, Shinya Toyokuni, Mitsunori Sasa, Yasuo Miyoshi, Toyomasa Katagiri
- Organizer
  第75回日本癌学会・学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-26461948
[Presentation] ホルモン療法耐性乳がん治療を目的とした分子内架橋型BIG3-PHB2相互作用阻害ペプチドの開発2016
- Author(s)
  吉丸哲郎, 小松正人, 片桐豊雅
- Organizer
  第20回日本がん分子標的治療学会学術集会
- Place of Presentation
  別府国際コンベンションセンター　大分県別府市
- Year and Date
  2016-05-30
- Data Source
  KAKENHI-PROJECT-16H05153
[Presentation] エストロゲン受容体制御分子BIG3を標的とした新規ER陽性乳がん治療法の開発2015
- Author(s)
  吉丸哲郎、小松正人、三好康雄、本田純子、笹三徳、片桐豊雅
- Organizer
  第72回徳島乳腺研究会
- Place of Presentation
  徳島大学病院日亜メディカルホール（徳島県徳島市）
- Year and Date
  2015-04-25
- Data Source
  KAKENHI-PROJECT-26461948
[Presentation] BIG3-PHB2 interaction is a key potential therapeutic target in luminal-type breast cancer2015
- Author(s)
  Tetsuro Yoshimaru, Masato Komatsu, Etsu Tashiro, Hiroyuki Osada, Masaya Imoto, Shinya Toyokuni, Yasuo Miyoshi, Mitsunori Sasa, Toyomasa Katagiri
- Organizer
  第74回日本癌学会・学術総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26461948
[Presentation] エストロゲン受容体制御分子BIG3を標的とした新規ER陽性乳がん治療法の創製2015
- Author(s)
  吉丸哲郎、小松正人、田代悦、長田裕之、井本正哉、片桐豊雅
- Organizer
  第19回日本がん分子標的治療学会
- Place of Presentation
  松山全日空ホテル（愛媛県松山市）
- Year and Date
  2015-06-10
- Data Source
  KAKENHI-PROJECT-26461948
[Presentation] ERα活性化制御分子ERAP1を標的とした内分泌療法耐性乳癌の治療戦略2013
- Author(s)
  吉丸哲郎, 小松正人, 松尾泰佑, 片桐豊雅
- Organizer
  第17回日本がん分子標的治療学会学術集会
- Place of Presentation
  国立京都国際会館、京都府
- Data Source
  KAKENHI-PROJECT-25293079
[Presentation] エストロゲン受容体活性化制御分子ERAP1と腫瘍抑制因子REAの相互作用を標的とした内分泌療法耐性乳癌の治療法の開発2013
- Author(s)
  吉丸哲郎, 小松正人, 松尾泰佑, 三好康雄, 笹三徳, 中村祐輔, 片桐豊雅
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜、神奈川県
- Data Source
  KAKENHI-PROJECT-25293079
[Presentation] ダニ抗原刺激による気管支喘息患者末梢血好中球の活性酸素産生能の解析2008
- Author(s)
  福永牧子、平山倫子、権寧博、布村聡、吉岡美乃、吉丸哲郎、橋本奈緒美、服部知洋、伊藤玲子、小林朋子、橋本修、羅智靖
- Organizer
  第58回日本アレルギー学会秋季学術大会ミニシンポジウム
- Place of Presentation
  東京国際フォーラム
- Year and Date
  2008-11-29
- Data Source
  KAKENHI-PROJECT-19790696
[Presentation] エストロゲン受容体制御分子BIG3を標的とした新規ER陽性乳がん治療法の創製
- Author(s)
  吉丸哲郎、小松正人、松尾泰祐、片桐豊雅
- Organizer
  第18回日本がん分子標的治療学会
- Place of Presentation
  TKPガーデンシティ仙台（宮城県仙台市）
- Year and Date
  2014-06-25 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-26461948
[Presentation] エストロゲン受容体制御分子BIG3を標的とした新規ER陽性乳がん治療法の創製
- Author(s)
  吉丸哲郎、小松正人、松尾泰佑、片桐豊雅
- Organizer
  第18回日本がん分子標的治療学会学術集会
- Place of Presentation
  TKPガーデンシティ仙台（宮城県仙台市）
- Year and Date
  2014-06-25 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-25293079
[Presentation] New therapeutics for luminal-type breast cancer targeting BIG3-PHB2 interaction
- Author(s)
  Tetsuro Yoshimaru, Masato Komatsu, Taisuke Matsuo, Yasuo Miyoshi, Mitsunori Sasa, Yusuke Nakamura, Toyomasa Katagiri
- Organizer
  第73回日本癌学会・学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26461948
[Presentation] 新規エストロゲンシグナル制御分子BIG3による新たながん抑制因子prohibitin2の機能喪失機構の解明
- Author(s)
  片桐豊雅、吉丸哲郎、小松正人
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25293079
[Presentation] トリプルネガティブ乳癌におけるプロテアソーム構成因子のプロテアソーム活性非依存的な役割
- Author(s)
  小松正人、吉丸哲郎、松尾泰佑、片桐豊雅
- Organizer
  第18回日本がん分子標的治療学会学術集会
- Place of Presentation
  TKPガーデンシティ仙台（宮城県仙台市）
- Year and Date
  2014-06-25 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-25293079

1. KATAGIRI Toyomasa (60291895)

# of Collaborated Projects: 4 results

# of Collaborated Products: 42 results
2. MIZUGUCHI Kenji (50450896)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
3. MIYOSHI Yasuo (50283784)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
4. MATSUSHITA Yosuke (70634450)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
5. ONO Masaya (00270900)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
6. OTAKA Akira (20201973)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
7. 清谷一馬 (30433642)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 内山圭司 (60294039)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. OKAZAKI Yasumasa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. SHI Lei

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 西岡安彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 豊國伸哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 中村努

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 井上豪

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 田代悦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 井本正哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 村上洋一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yoshimaru Tetsuro 吉丸 哲郎

YOSHIMARU Tetsuro 吉丸 哲郎

吉丸 哲郎 ヨシマル テツロウ

Research Projects

Research Products

Co-Researchers

A therapeutic strategy to overcome drug resistance in HER2-positive breast cancer targeting the BIG3-PHB2 complexesPrincipal Investigator

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BIG3-PHB2 complexes is required for the acquired trastuzumab-resistance of HER2-positive breast cancerPrincipal Investigator

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Acquired resistance to hormone therapy of breast cancer by mitochondrial reactive oxygen speciesPrincipal Investigator

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Drug discovery in breast cancer utilizing reactivation of tumor suppressors

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Clarification of novel pathophysiological roles of BIG3 in breast cancer cells

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Therapeutic advances in BIG3-PHB2 inhibition targeting the cross-talk between estrogen and growth factors in breast cancerPrincipal Investigator

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Drug development and biological function study of novel estrogen receptor activity modulator BIG3 protein

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次世代シークエンサーによる新規乳がん関連遺伝子の探索

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ミトコンドリア由来活性酸素を標的とした免疫難病治療の新戦略Principal Investigator

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Extracellular superoxide released from neutrophil is a critical determinant of severity of asthmatic symptoms : Role of Fcε I in asthmatic patient.Principal Investigator

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[Book] Precision Medicine2018

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[Journal Article] The survival and proliferation of osteosarcoma cells are dependent on the mitochondrial BIG3‐PHB2 complex formation2021

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[Journal Article] Functional genomics for breast cancer drug target discovery.2021

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Yoshimaru Tetsuro 吉丸哲郎

YOSHIMARU Tetsuro 吉丸哲郎

吉丸哲郎ヨシマルテツロウ