Suenaga Yusuke 末永雄介

… Alternative Names

SUENAGA Yusuke 末永雄介

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Researcher Number	80581793
Other IDs	https://orcid.org/0000-0001-6902-5386
Affiliation (Current)	2024: 千葉県がんセンター(研究所), がんゲノムセンター進化腫瘍学研究室, 室長
Affiliation (based on the past Project Information) *help	2024: 千葉県がんセンター(研究所), がんゲノムセンター進化腫瘍学研究室, 上席研究員 2024: 千葉県がんセンター(研究所), がんゲノムセンター進化腫瘍学研究室, 室長 2018 – 2023: 千葉県がんセンター(研究所), 発がん研究グループ発がん制御研究部, 研究員 2014 – 2017: 千葉県がんセンター(研究所), がんゲノムセンター, 研究員 2014: 千葉県がんセンター(研究所), 臨床ゲノム研究室, 研究員 … More 2012 – 2013: 千葉県がんセンター(研究所), がん先進治療開発研究室, 研究員 2011 – 2013: 千葉県がんセンター(研究所), がん治療開発グループ, 研究員 2010 – 2011: 千葉県がんセンター(研究所), 研究局・がん治療開発グループ, 研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Basic Section 55010:General surgery and pediatric surgery-related / Basic Section 53030:Respiratory medicine-related / Respiratory organ internal medicine / Carcinogenesis / Pediatrics Except Principal Investigator Basic Section 56010:Neurosurgery-related / Basic Section 49030:Experimental pathology-related / Basic Section 53010:Gastroenterology-related / Basic Section 55010:General surgery and pediatric surgery-related / Basic Section 50010:Tumor biology-related / Pediatrics
Keywords	Principal Investigator MYCN / NCYM / POMC / ホルモン / 下垂体 / 小細胞肺癌 / Myc-nick / p63 / 神経芽腫 / がん … More / オートファジー / Caspase-2 / 分裂期崩壊 / 分裂期チェックポイント / VUVCD / SNP / ORFドミナンス / 化合物スクリーニング / 3次元培養 / 下垂体分化 / 神経内分泌性格 / 神経分化 / PAX6 / LHX3 / OTX2 / 下垂体前葉ホルモン / スパイン / シナプス / NE-NSCLC / SCLC / NE-SCLC / 次世代シーケンサー / 肺癌 / 神経内分泌腫瘍 / 口腔外胚葉 / ラトケ嚢 / 発生 / 脱分化 / 分化 / 転写因子 / 神経内分泌 / de novo evolved protein / de novo gene birth / De novo evolved protein / cis-antisense gene / De novo gene birth / Neuroblastoma / N-CYM / metastasis / transgenic mouse / stem cell / OCT4 / neuroblastoma / 転写制御 / P63 / P53ファミリー遺伝子 / GSK3 / p53ファミリー遺伝子 / GSK3β / 遺伝子増幅 / Natural Antisense RNA … More Except Principal Investigator MYCN / NCYM / glioblastoma / 神経芽腫 / オルガノイド / 子宮体がん / outer radial glia / 膵癌 / 胆道癌 / ORFドミナンス / 膠芽腫 / モネンシン / monensin / Caspase2 / Glioblastoma / Monensin / MYC / 卵巣癌 / BRCA2 / 遺伝性腫瘍 / 乳癌 / 遺伝性乳癌 / checkpoint kinase 1 / 10q loss / CHP134 / p63 / DNA-PK / ATM / FGFR２ / kinase inhibitor / neuroblastoma / ERK / MEK / CHK1 / DNA損傷修復 / DNA-PK阻害剤 / MEK阻害剤 / FGFR2 / CEP131 / DNA損傷応答 / CHK1阻害剤 / ShcC / ALK / TrkB / in silico screening / 創薬 Less

子宮内膜発がんにおける多段階発がんとがん多様性創出の分子機構解明
- Principal Investigator
  
  筆宝義隆
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Chiba Cancer Center (Research Institute)
NCYMによるオートファジー制御とその胆管発がんへの寄与の解明Principal Investigator
- Principal Investigator
  
  末永雄介
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Chiba Cancer Center (Research Institute)
Usefulness of ORF dominance as a novel biomarker in cholangiopancreatic cancer
- Principal Investigator
  
  喜多絵美里
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Chiba Cancer Center (Research Institute)
Elucidation of MYCN/NCYM function in outer radial glial cell
- Principal Investigator
  
  瀬戸口大毅
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Chiba Cancer Center (Research Institute)
NCYMによる分裂期制御機構とその神経芽腫発がんへの寄与の解明Principal Investigator
- Principal Investigator
  
  末永雄介
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Chiba Cancer Center (Research Institute)
Development of innovative treatment for glioblastoma targeting MYC family genes
- Principal Investigator
  
  Setoguchi Taiki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Chiba Cancer Center (Research Institute)
Clinical application and biomarker of CHK1 inhibitor-mediated cell death
- Principal Investigator
  
  Ando Kiyohiro
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Research Institute for Clinical Oncology Saitama Cancer Center
  Showa University
Anticancer drug screen in small cell lung cancer using a pituitary differentiation regulators as an indicatorPrincipal Investigator
- Principal Investigator
  
  Suenaga Yusuke
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Chiba Cancer Center (Research Institute)
Elucidation of the mechanism of hereditary breast cancer caused by a novel germline mutation in BRCA2
- Principal Investigator
  
  NAKAMURA RIKIYA
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Chiba Cancer Center (Research Institute)
Identification of regulatory factors of neuroendocrine features in lung cancersPrincipal Investigator
- Principal Investigator
  
  Suenaga Yusuke
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Chiba Cancer Center (Research Institute)
Generation of the MYCN/NCYM mouse model and the drug discovery for human neuroblastoma
- Principal Investigator
  
  NAKAGAWARA Akira
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Pediatrics
- Research Institution
  Kyushu University
  Chiba Cancer Center (Research Institute)
Neuroblastoma mouse model developing metastatic tumorsPrincipal Investigator
- Principal Investigator
  
  SUENAGA Yusuke
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Carcinogenesis
- Research Institution
  Chiba Cancer Center (Research Institute)
Functional roles of cis-antisense gene of MYCN, NCYM, in human neuroblastomaPrincipal Investigator
- Principal Investigator
  
  SUENAGA Yusuke
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Pediatrics
- Research Institution
  Chiba Cancer Center (Research Institute)

[Book] Molecular Mechanisms and Treatment of MYCN-driven Tumors2022
- Author(s)
  Suenaga Y., Einvik C., Takatori A., Zhu Y.
- Total Pages
  159
- Publisher
  Frontiers Media SA.
- ISBN
  9782889740956
- Data Source
  KAKENHI-PROJECT-21K08610
[Book] 神経内分泌腫瘍と脳腫瘍におけるMYCファミリー遺伝子（実験医学3月号）2018
- Author(s)
  末永雄介、中川原章、横井左奈
- Total Pages
  7
- Publisher
  羊土社
- ISBN
  9784758125055
- Data Source
  KAKENHI-PROJECT-15K19438
[Book] がん生物学イラストレイテッド2011
- Author(s)
  末永雄介
- Total Pages
  5
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-22890241
[Book] がん生物学イラストレイテッド
- Author(s)
  末永雄介、中川原章
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-22890241
[Journal Article] Secondary structure of human De Novo evolved gene product NCYM analyzed by vacuum-ultraviolet circular dichroism2021
- Author(s)
  T. Matsuo, K. Nakatani, T. Setoguchi, K. Matsuo, T. Tamada, Y. Suenaga
- Journal Title
  
  Front. Oncol.
  
  Volume: 11 Pages: 688852-688852
- DOI
  10.3389/fonc.2021.688852
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06587, KAKENHI-PROJECT-21K08610
[Journal Article] FGFR2 loss sensitizes MYCN‐amplified neuroblastoma CHP134 cells to CHK1 inhibitor?induced apoptosis2021
- Author(s)
  Ando Kiyohiro、Ohira Miki、Takada Ichiro、Cazares‐Ordonez Verna、Suenaga Yusuke、Nagase Hiroki、Kobayashi Shinichi、Koshinaga Tsugumichi、Kamijo Takehiko、Makishima Makoto、Wada Satoshi
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 2 Pages: 587-596
- DOI
  10.1111/cas.15205
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07246, KAKENHI-PROJECT-20K08269
[Journal Article] De novo evolved gene product NCYM in the pathogenesis and clinical outcome of human neuroblastomas and other cancers2020
- Author(s)
  Suenaga Yusuke、Nakatani Kazuma、Nakagawara Akira
- Journal Title
  
  Japanese Journal of Clinical Oncology
  
  Volume: 50 Issue: 8 Pages: 839-846
- DOI
  10.1093/jjco/hyaa097
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08162
[Journal Article] TAp63 represses transcription of MYCN/NCYM gene and its high levels of expression are associated with favorable outcome in neuroblastoma2019
- Author(s)
  Suenaga Yusuke、Yamamoto Mami、Sakuma Tetsushi、Sasada Manabu、Fukai Fumio、Ohira Miki、Yamaguchi Yohko、Yamamoto Takashi、Ando Kiyohiro、Ozaki Toshinori、Nakagawara Akira
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 518 Issue: 2 Pages: 311-318
- DOI
  10.1016/j.bbrc.2019.08.052
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07246, KAKENHI-PROJECT-19K16111, KAKENHI-PROJECT-17K10131
[Journal Article] NCYM promotes calpain-mediated Myc-nick production in human MYCN-amplified neuroblastoma cells2015
- Author(s)
  Shoji W, Suenaga Y, Kaneko Y, Islam SM, Alagu J, Yokoi S, Nio M, Nakagawara A
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: PMID: 25896758 Issue: 3 Pages: 501-506
- DOI
  10.1016/j.bbrc.2015.04.050
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24700957
[Journal Article] Functional interplay between MYCN, NCYM and OCT4 promotes aggressiveness of human neuroblastomas.2015
- Author(s)
  Kaneko Y, Suenaga Y, Islam SM, Matsumoto D, Nakamura Y, Ohira M, Yokoi S, Nakagawara A.
- Journal Title
  
  Cancer Sci.
  
  Volume: 10 Issue: 7 Pages: 12677-12677
- DOI
  10.1111/cas.12677
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24592703, KAKENHI-PROJECT-24700957, KAKENHI-PROJECT-15K08720, KAKENHI-PROJECT-26461603
[Journal Article] NCYM, a Cis-antisense gene of MYCN,　encodes a de novo evolved protein that inhibits GSK3β resulting in the　stabilization of MYCN in human neuroblastomas.2014
- Author(s)
  Suenaga Y, Islam SM, Alagu J, Kaneko Y, Kato M, Tanaka Y, Kawana H, Hossain S,　Matsumoto D, Yamamoto M, Shoji W, Itami M, Shibata T, Nakamura Y, Ohira M,　Haraguchi S, Takatori　A, Nakagawara A.
- Journal Title
  
  PLoS Genet
  
  Volume: 10 Issue: 1 Pages: 1-14
- DOI
  10.1371/journal.pgen.1003996
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23591562, KAKENHI-PROJECT-24249061, KAKENHI-PROJECT-24592703, KAKENHI-PROJECT-24700957, KAKENHI-PROJECT-25830092
[Journal Article] RUNX3 interacts with MYCN and facilitates protein degradation in neuroblastoma.2013
- Author(s)
  Yu F, Gao W, Yokochi T, Suenaga Y, Ando K, Ohira M, Nakamura Y, Nakagawara A.
- Journal Title
  
  Oncogene
  
  Volume: 33 Issue: 20 Pages: 2601-2609
- DOI
  10.1038/onc.2013.221
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23591562, KAKENHI-PROJECT-24249061, KAKENHI-PROJECT-24592703
[Journal Article] Temozolomide suppresses MYC via activation of TAp63 to inhibit progression of human glioblastoma.2013
- Author(s)
  Yamaki T, Suenaga Y, Iuchi T, Alagu J, Takatori A, Itami M, Araki A, Ohira M, Inoue M, Kageyama H, Yokoi S, Saeki N, Nakagawara A.
- Journal Title
  
  Sci Rep.
  
  Volume: 3 Issue: 1 Pages: 1160-1160
- DOI
  10.1038/srep01160
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591562, KAKENHI-PROJECT-24249061, KAKENHI-PROJECT-24592179
[Journal Article] ALK is a MYCN target　gene and regulates cell migration and invasion in neuroblastoma.2013
- Author(s)
  Hasan MK, Nafady A, Takatori A, Kishida S, Ohira M, Suenaga Y, Hossain S,　Akter J, Ogura A, Nakamura Y, Kadomatsu K, Nakagawara A.
- Journal Title
  
  Sci Rep
  
  Volume: 3 Issue: 1 Pages: 3450-3450
- DOI
  10.1038/srep03450
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591562, KAKENHI-PROJECT-24249061, KAKENHI-PROJECT-24590377, KAKENHI-PROJECT-24592703
[Journal Article] NFBD1/MDC1 participates in the regulation of G2/M transition in mammalian cells.2010
- Author(s)
  Bu Y., Suenaga Y., Okoshi R., Sang M., Kubo N., Song F., Nakagawara A., Ozaki T.
- Journal Title
  
  Biochem.Biophys.Res.Commun.
  
  Volume: 397 Pages: 157-162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890241
[Journal Article] RUNX3 modulates DNA damage-mediated phosphorylation of tumor suppressor p53 at Ser-15 and acts as a Co-activator for p532010
- Author(s)
  Yamada C., Ozaki T., Ando K., Suenaga Y., Inoue K., Ito Y., Okoshi R., Kageyama H., Kimura H., Miyazaki M., Nakagawara A.
- Journal Title
  
  J.Biol.Chem.
  
  Volume: 285 Pages: 16693-16703
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890241
[Patent] 神経芽腫モデルマウス2012
- Inventor(s)
  中川原　章、末永　雄介
- Industrial Property Rights Holder
  中川原　章
- Industrial Property Rights Type
  特許
- Filing Date
  2012-10-02
- Data Source
  KAKENHI-PROJECT-24700957
[Presentation] CRISPR-dCas9-based inhibition of OCT4 binding at the MYCN locus induces neuroblastoma cell death.2022
- Author(s)
  K Nakatani, T Sakuma, T Yamamoto, Y Hippo, Y Suenaga
- Organizer
  第64回日本小児血液・がん学会
- Data Source
  KAKENHI-PROJECT-21K08610
[Presentation] CRISPR-dCas9-based inhibition of OCT4 binding at the MYCN locus induces neuroblastoma cell death accompanied by the downregulation of RNA translational efficiency.2022
- Author(s)
  K Nakatani, H Kogashi, T Sakuma, T Yamamoto, Y Hippo, Y Suenaga
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K08610
[Presentation] Identification of amino acid residues that modulate NCYM function using protein perdeuteration.2022
- Author(s)
  K Nakatani, T Matsuo, K Mastuo, T Tamada, Y Suenaga
- Organizer
  第81回日本がん学会学術総会
- Data Source
  KAKENHI-PROJECT-21K08610
[Presentation] CRISPR-dCas9-based transcription factor blockage at the MYCN locus induces caspase 2-mediated neuroblastoma cell death2021
- Author(s)
  K. Nakatani, T. Sakuma, T. Yamamoto, Y. Hippo, Y. Suenaga
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K08610
[Presentation] Proof of concept for therapeutic targeting of the MYCN/NCYM positive feedback regulation in the neuroblastoma2021
- Author(s)
  K. Nakatani, T. Matsuo, K. Matsuo, T. Tamada, T. Sakuma, T. Yamamoto, Y. Hippo, Y. Suenaga
- Organizer
  先端モデル動物支援プラットフォーム（AdAMS）、2021年度若手支援技術講習会
- Data Source
  KAKENHI-PROJECT-21K08610
[Presentation] Functional and structural characterization of de novo evolved proteins2021
- Author(s)
  Y. Suenaga
- Organizer
  Seminaire Laboratoire Interdisciplinaire de Physique
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08610
[Presentation] FGFR2の欠失はCHK1阻害剤が誘導する細胞死の感受性を増強する2020
- Author(s)
  安藤清宏、大平美紀、末永雄介、上條岳彦、永瀬浩喜、小林真一、和田聡
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07246
[Presentation] Inhibitors of pituitary differentiation reduce cell proliferation of small cell lung carcinomas2018
- Author(s)
  Yusuke Suenaga, Masato Shingyoji, Sotaro Kanematsu, Toshihiko Iizasa, Mamoru Kato, Sana Yokoi
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K08162
[Presentation] 肺癌の神経内分泌性格を制御する分子機構の解析2018
- Author(s)
  末永雄介、新行内雅斗、兼松宗太郎、飯笹俊彦、加藤護、横井左奈
- Organizer
  第27回日本癌病態治療研究会
- Data Source
  KAKENHI-PROJECT-18K08162
[Presentation] 下垂体前葉発生に関与する転写因子は小細胞肺癌の神経内分泌性格を制御する2017
- Author(s)
  末永雄介、新行内雅斗、兼松宗太郎、飯笹俊彦、加藤護、横井左奈
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-15K19438
[Presentation] 肺癌の神経内分泌性格を制御する分子機構の解析2017
- Author(s)
  末永雄介
- Organizer
  平成29年度第1回　生物系若手研究者講話（明治薬科大学）
- Invited
- Data Source
  KAKENHI-PROJECT-15K19438
[Presentation] 肺癌の神経内分泌性格を制御する分子機構の解析2017
- Author(s)
  末永雄介
- Organizer
  平成29年度　第 1 回　生物系若手研究者講話
- Place of Presentation
  明治薬科大学
- Year and Date
  2017-06-09
- Invited
- Data Source
  KAKENHI-PROJECT-15K19438
[Presentation] 下垂体前葉発生に関与する転写因子は小細胞肺癌の神経内分泌性格を制御する2017
- Author(s)
  末永雄介、新行内雅斗、兼松宗太郎、飯笹俊彦、加藤護、横井左奈
- Organizer
  ConBio 2017
- Data Source
  KAKENHI-PROJECT-15K19438
[Presentation] 神経内分泌分化を制御する転写因子の下流遺伝子は小細胞肺癌において鋳型鎖・非鋳型鎖の変異率に強い非対称性を示す2016
- Author(s)
  末永雄介、新行内雅斗、兼松宗太郎、飯笹俊彦、加藤護、横井左奈
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K19438
[Presentation] Frequent somatic mutations in neuroendocrine differentiation-related pathways in SCLC-transformed lung adenocarcinomas2015
- Author(s)
  Yusuke Suenaga, Masato Shingyoji, Mamoru Kato, Isao Kurosaka, Miki Ohira, Tishihiko Iizasa, Hiroki Nagase, Sana Yokoi
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K19438
[Presentation] Frequent somatic mutations in neuroendocrine differentiation-related pathways in SCLC-transformed lung adenocarcinomas2015
- Author(s)
  Yusuke Suenaga, Masato Shingyoji, Mamoru Kato, Isao Kurosaka, Miki Ohira, Tishihiko Iizasa, Hiroki Nagase, Sana Yokoi
- Organizer
  日本人類遺伝学会第60回大会
- Place of Presentation
  新宿
- Year and Date
  2015-10-14
- Data Source
  KAKENHI-PROJECT-15K19438
[Presentation] NCYM Promotes Production of Myc-nick of MYCN in Neuroblastoma2014
- Author(s)
  Wataru Shoji, Yusuke Suenaga, S. M. Rafiqul Islam, Masaki Nio, Akira Nakagawara
- Organizer
  ADVANCES IN NEUROBLASTOMA RESEARCH　2014
- Place of Presentation
  ケルン
- Data Source
  KAKENHI-PROJECT-24700957
[Presentation] NCYM Maintains Stemness via the Induction of OCT4 Expression in Neuroblastoma2014
- Author(s)
  Yoshiki Kaneko, Yusuke Suenaga, S. M. Rafiqul Islam, Daisuke Matsumoto, Yohko Nakamura, Miki Ohira and Akira Nakagawara
- Organizer
  ADVANCES IN NEUROBLASTOMA RESEARCH　2014
- Place of Presentation
  ケルン
- Data Source
  KAKENHI-PROJECT-24700957
[Presentation] NCYM, a Cis-Antisense Gene of MYCN, is a De Novo Evolved Gene2014
- Author(s)
  Yusuke Suenaga, Mamoru Kato, Tatsuhiro Shibata, and Akira Nakagawara
- Organizer
  ADVANCES IN NEUROBLASTOMA RESEARCH　2014
- Place of Presentation
  ケルン
- Data Source
  KAKENHI-PROJECT-24700957
[Presentation] 神経芽腫における de novo gene NCYMの機能2014
- Author(s)
  末永雄介
- Organizer
  独立行政法人国立がん研究センターセミナー
- Place of Presentation
  独立行政法人国立がん研究センター
- Year and Date
  2014-07-23
- Invited
- Data Source
  KAKENHI-PROJECT-24700957
[Presentation] MYCNのアンチセンス遺伝子であるNCYMはMYCN機能の制御を介して神経芽腫の悪性化に寄与する2014
- Author(s)
  末永雄介
- Organizer
  独立行政法人　放射線医学総合研究所　セミナー
- Place of Presentation
  独立行政法人　放射線医学総合研究所
- Year and Date
  2014-07-17
- Invited
- Data Source
  KAKENHI-PROJECT-24700957
[Presentation] NCYM induces OCT4 via stabilization of MYCN in neuroblastoma2013
- Author(s)
  Yoshiki Kaneko, Yusuke Suenaga, S. M. Rafiqul Islam, Daisuke Matsumoto, Yohko Nakamura, Miki Ohira, Akira Nakagawara
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24700957
[Presentation] NCYM induces OCT4 via the stabilization of MYCN in human neuroblastoma2013
- Author(s)
  Yoshiki Kaneko, Yusuke Suenaga, S. M. Rafiqul Islam, Daisuke Matsumoto, Yohko Nakamura, Miki Ohira, Akira Nakagawara
- Organizer
  平成25年度がん若手研究者ワークショップ
- Place of Presentation
  蓼科
- Data Source
  KAKENHI-PROJECT-24700957
[Presentation] NCYM, a novel MYCN cis-antisense gene product, stabilizes MYCN and contributes to aggressiveness of human neuroblastoma2012
- Author(s)
  Yusuke Suenaga, Atsushi Takatori, Hidetada Kawana, Yoshiki Kaneko, Daisuke Matsumoto, Wataru Shoji, Mohammad Shamim Hossain, MikiOhira, Makiko Itami, Seiki Haraguchi, and Akira Nakagawara
- Organizer
  Advances in Neuroblastoma Research Conference 2012
- Place of Presentation
  トロント
- Data Source
  KAKENHI-PROJECT-24700957
[Presentation] Functional roles of TLP-TAp63 pathway in human cancer2012
- Author(s)
  末永雄介
- Organizer
  河北医科大学　訪問及び講演
- Place of Presentation
  石家荘市
- Invited
- Data Source
  KAKENHI-PROJECT-24700957
[Presentation] NCYM, a novel MYCN cis-antisense gene product,　stabilizes MYCN and contributes to aggressiveness of human neuroblastoma2012
- Author(s)
  末永雄介、高取敦志、金子伊樹、川名秀忠、エスエム　ラフィクルイスラム、ジェニファーアラグー、モハマド　シャミンホセイン、松本大介、庄子渉、伊丹真紀子、中村洋子、大平美紀、原口清輝、中川原章
- Organizer
  平成24年度がん若手研究者ワークショップ
- Place of Presentation
  蓼科
- Data Source
  KAKENHI-PROJECT-24700957
[Presentation] 神経系腫瘍の増殖制御におけるTAp63とMycの機能的役割2012
- Author(s)
  末永雄介、八巻智洋、 Jennifer Alagu、高取敦志、金子伊樹、松本大介、 Shamim Hossain、 S. M. Rafiqul Islam、庄子渉、中村洋子、大平美紀、原口清輝、中川原章
- Organizer
  第71日本癌学会学術総会
- Place of Presentation
  札幌
- Invited
- Data Source
  KAKENHI-PROJECT-24700957
[Presentation] NCYMはMYCNを安定化し、神経芽腫悪性化に寄与する2011
- Author(s)
  Yusuke Suenaga, Daisuke Matsumoto, Yoshiki Kaneko, Mohammad Shamim Hossain, Atushi Takatori, Yohko Nakamura, Miki Ohira, Seiki Haraguchi, Akira Nakagawara
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-22890241
[Presentation] NCYMはMYCNを安定化し、神経芽腫悪性化に寄与する2011
- Author(s)
  末永雄介
- Organizer
  第17回神経芽腫研究会・症例検討会
- Place of Presentation
  京都府立医科大学
- Year and Date
  2011-09-03
- Data Source
  KAKENHI-PROJECT-22890241
[Presentation] NCYM stabilizes MYCN and contributes to aggresiveness of neuroblastoma2011
- Author(s)
  末永雄介
- Organizer
  5^<th> International p63/73 workshop
- Place of Presentation
  フランス(リヨン)
- Data Source
  KAKENHI-PROJECT-22890241
[Presentation] NCYM stabilizes MYCN and contributes to aggresiveness of neuroblastoma2011
- Author(s)
  Yusuke Suenaga, Daisuke Matsumoto, Yoshiki Kaneko, Mohammad Shamim Hossain, Atsushi Takatori, Yohko Nakamura, Miki Ohira, Seiki Haraguchi, Akira Nakagawara
- Organizer
  5^<th> International p63/73 workshop
- Place of Presentation
  リヨン(フランス)
- Data Source
  KAKENHI-PROJECT-22890241
[Presentation] NCYMはMYCNを安定化し、神経芽腫悪性化に寄与する2011
- Author(s)
  末永雄介
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-22890241
[Presentation] NCYM induces Oct3/4 expression in neuroblastoma2010
- Author(s)
  Yoshiki kaneko, Yusuke Suenaga, Daisuke Matsumoto, Yohko Nakamura, Miki Ohira, Akira Nakagawara
- Organizer
  第69日本癌学会学術総会
- Place of Presentation
  大阪国際会議場(大阪市)
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-22890241
[Presentation] NCYM, an antisense transcript of MYCN, induces expression of reprogramming factors in human neuroblastoma2010
- Author(s)
  Yoshiki Kaneko, Yusuke Suenaga, Daisuke Matsumoto, Yohko Nakamura, Miki Ohira, Akira Nakagawara
- Organizer
  第33回日本分子生物学会年会, 第83回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド(神戸市)
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-22890241
[Presentation] MYCNアンチセンス遺伝子NCYMは神経芽腫予後不良群で高発現し、MYCNの発現を誘導する2010
- Author(s)
  末永雄介、金子伊樹、松本大介、中村洋子、大平美紀、中川原章
- Organizer
  第26回日本小児がん学会学術総会
- Place of Presentation
  大阪国際会議場(大阪市)
- Year and Date
  2010-12-17
- Data Source
  KAKENHI-PROJECT-22890241
[Presentation] NCYM, a protein product of an natural antisense MYCN gene co-amplified with MYCN, targets MYCN for functional modulation and affects the prognosis of neuroblastoma2010
- Author(s)
  Yusuke Suenaga, Yoshiki Kaneko, Daisuke Matsumoto, Yohko Nakamura, Miki Ohira, Toshinori Ozaki, Akira Nakagawara
- Organizer
  Advances in Neuroblastoma Research 2010
- Place of Presentation
  The Stockholm City Conference Centre(Stockholm)
- Year and Date
  2010-06-22
- Data Source
  KAKENHI-PROJECT-22890241
[Presentation] Natural MYCN antisense gene, NCYM, functions as an oncogene in neuroblastoma through induction of MYCN2010
- Author(s)
  Yusuke Suenaga, Yoshiki Kaneko, Yoshiki Kaneko, Daisuke Matsumoto, Yohko Nakamura, Miki Ohira, Seiki Haraguchi, Akira Nakagawara
- Organizer
  第69日本癌学会学術総会
- Place of Presentation
  大阪国際会議場(大阪市)
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-22890241
[Presentation] Natural MYCN antisense gene, NCYM, functions asan oncogene in neuroblastoma through induction of MYCN2010
- Author(s)
  Yusuke Suenaga, Yoshiki Kaneko, Daisuke Matsumoto, Yohko Nakamura, Miki Ohira, Seiki Haraguchi, Akira Nakagawara
- Organizer
  第69日本癌学会学術総会
- Place of Presentation
  大阪国際会議場(大阪市)
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-22890241
[Presentation] Transcriptional repression of MYCN is mediated by TAp63 in human neuroblastomas2010
- Author(s)
  Yusuke Suenaga, Yoshiki Kaneko, Mami Yamamoto, Daisuke Matsumoto, Tomoe Ichikawa, Toshiyuki Moritan, Takehiko Kamijo, Yohko Nakamura, Miki Ohira, Toshinori Ozaki, Akira Nakagawara
- Organizer
  American Association for Cancer Research 101st ANNUAL MEETING
- Place of Presentation
  Washington Convention Center(Washington, DC)
- Year and Date
  2010-04-21
- Data Source
  KAKENHI-PROJECT-22890241
[Presentation] MYCNの相補鎖遺伝子産物NCYMは神経芽腫においてリプログラミングファクターの発現を誘導する2010
- Author(s)
  金子伊樹、末永雄介、松本大介、中村洋子、大平美紀、中川原章
- Organizer
  第26回日本小児がん学会学術総会
- Place of Presentation
  大阪国際会議場(大阪市)
- Year and Date
  2010-12-18
- Data Source
  KAKENHI-PROJECT-22890241
[Presentation] Transcriptional repression of MYCN is mediated byTAp63 in human neuroblastomas.2010
- Author(s)
  Yusuke Suenaga, Yoshiki Kaneko, Mami Yamamoto, Daisuke Matsumoto, Tomoe Ichikawa, Toshiyuki Moritan, Takehiko Kamijo, Yohko Nakamura, Miki Ohira, Toshinori Ozaki, Akira Nakagawara
- Organizer
  American Association for Cancer Research 101st ANNUAL MEETING
- Place of Presentation
  Walter E.Washington Convention Center(Washington,DC)
- Year and Date
  2010-04-21
- Data Source
  KAKENHI-PROJECT-22890241
[Presentation] NCYM induces Oct3/4 expression in neuroblastoma2010
- Author(s)
  Yoshiki Kaneko, Yusuke Suenaga, Daisuke Matsumoto, Yohko Nakamura, Miki Ohira, Akira Nakagawara
- Organizer
  日本分子生物学会第10回春季シンポジウム
- Place of Presentation
  ホテル松島大観荘(宮城郡)
- Year and Date
  2010-06-07
- Data Source
  KAKENHI-PROJECT-22890241
[Presentation] NCYM maintains stemness via the induction of OCT4 expression in neuroblastoma
- Author(s)
  Yoshiki Kaneko, Yusuke Suenaga, S. M. Rafiqul Islam, Daisuke Matsumoto, Yohko Nakamura, Miki Ohira and Akira Nakagawara
- Organizer
  Advances in Neuroblastoma Research 2014
- Place of Presentation
  ケルン
- Year and Date
  2014-05-12 – 2014-05-16
- Data Source
  KAKENHI-PROJECT-24700957
[Presentation] MYCNのアンチセンス遺伝子から進化したde novo geneであるNCYMはヒトの神経芽腫においてMYCN機能を制御する
- Author(s)
  末永雄介, 庄子渉, イスラムラフィクル, アラグージェニファー, 金子伊樹, 加藤護, 田中祐吉, 川名秀忠, ホセインシャミム, 伊丹真紀子, 柴田龍弘, 中村洋子, 大平美紀, 原口清輝, 横井左奈, 中川原章
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-24700957
[Presentation] NCYM promotes production of Myc-nick in neuroblastoma
- Author(s)
  Wataru Shoji、Yusuke Suenaga、S. M. Rafiqul Islam、Masaki Nio、Akira Nakagawara
- Organizer
  Advances in Neuroblastoma Research 2014
- Place of Presentation
  ケルン
- Year and Date
  2014-05-12 – 2014-05-16
- Data Source
  KAKENHI-PROJECT-24700957
[Presentation] MYCNのアンチセンス遺伝子から進化したde novo 遺伝子産物であるNCYMはヒトの神経芽腫においてMYCN機能を制御する
- Author(s)
  末永雄介, 庄子渉, ラフィクルイスラム, アラグージェニファー,　金子伊樹, 加藤護, 田中祐吉, 川名秀忠, シャミムホセイン, 伊丹真紀子、柴田　龍弘, 中村洋子, 大平美紀, 原口清輝, 横井左奈, 中川原章
- Organizer
  第87回日本生化学会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-24700957
[Presentation] NCYM, a cis-antisense gene of MYCN, is a TAp63 target gene that encode a de novo evolved protein stabilizing MYCN in human neuroblastoma
- Author(s)
  Yusuke Suenaga, S.M. Rafiqul Islam, Jennifer Alagu, Mamoru Kato, Yukichi Tanaka, Hidetada Kawana, Shamim Hossain, Daisuke Matsumoto, Mami Yamomoto, Wataru Shoji, Makiko Itami, Tatsuhiro Shibata, Yohko Nakamura, Miki Ohira, Seiki Haraguchi, Atsushi Takatori and Akira Nakagawara
- Organizer
  6th p63/p73 International Workshop
- Place of Presentation
  木更津
- Data Source
  KAKENHI-PROJECT-24700957
[Presentation] NCYM, a de novo gene evolved from MYCN cis-antisense genes, encodes a protein regulating MYCN functions in human neuroblastomas
- Author(s)
  Yusuke Suenaga, Wataru Shoji, Rafiqul Islam, Jennifer Alagu, Yoshiki Kaneko, Mamoru Kato, Yukichi Tanaka, Hidetada Kawana, Shamim Hossain, Makiko Itami, Tatsuhiro Shibata, Yohko Nakamura, Miki Ohira, Seiki Haraguchi, Sana Yokoi, Akira Nakagawara
- Organizer
  The 9th 3R symposium
- Place of Presentation
  御殿場
- Year and Date
  2014-11-17 – 2014-11-21
- Data Source
  KAKENHI-PROJECT-24700957
[Presentation] NCYM, a cis-antisense gene of MYCN, is a de novo evolved gene
- Author(s)
  Yusuke Suenaga, Mamoru Kato, Tatsuhiro Shibata, and Akira Nakagawara
- Organizer
  Advances in Neuroblastoma Research 2014
- Place of Presentation
  ケルン
- Year and Date
  2014-05-12 – 2014-05-16
- Data Source
  KAKENHI-PROJECT-24700957

1. 筆宝義隆 (30359632)

# of Collaborated Projects: 5 results

# of Collaborated Products: 4 results
2. TAKATORI Athushi (40455390)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. NAKAMURA Youko (60260254)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. Ando Kiyohiro (10455389)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
5. Setoguchi Taiki (90869926)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 横井左奈 (30372452)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
7. 井内俊彦 (80370881)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. NAKAGAWARA Akira (50117181)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
9. OOHIRA Miki (20311384)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. NAKAMURA RIKIYA (50456026)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 山本尚人 (40506169)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 喜多絵美里 (20773980)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 丸喜明 (30742754)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 板倉英祐 (90754218)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 市川美紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
16. 松尾光一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Suenaga Yusuke 末永 雄介

SUENAGA Yusuke 末永 雄介

Research Projects

Research Products

Co-Researchers

子宮内膜発がんにおける多段階発がんとがん多様性創出の分子機構解明

Principal Investigator

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NCYMによるオートファジー制御とその胆管発がんへの寄与の解明Principal Investigator

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Usefulness of ORF dominance as a novel biomarker in cholangiopancreatic cancer

Principal Investigator

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Elucidation of MYCN/NCYM function in outer radial glial cell

Principal Investigator

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NCYMによる分裂期制御機構とその神経芽腫発がんへの寄与の解明Principal Investigator

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Development of innovative treatment for glioblastoma targeting MYC family genes

Principal Investigator

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Clinical application and biomarker of CHK1 inhibitor-mediated cell death

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Anticancer drug screen in small cell lung cancer using a pituitary differentiation regulators as an indicatorPrincipal Investigator

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Elucidation of the mechanism of hereditary breast cancer caused by a novel germline mutation in BRCA2

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Identification of regulatory factors of neuroendocrine features in lung cancersPrincipal Investigator

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Generation of the MYCN/NCYM mouse model and the drug discovery for human neuroblastoma

Principal Investigator

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Neuroblastoma mouse model developing metastatic tumorsPrincipal Investigator

Principal Investigator

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Functional roles of cis-antisense gene of MYCN, NCYM, in human neuroblastomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Suenaga Yusuke 末永雄介

SUENAGA Yusuke 末永雄介

[Book] 神経内分泌腫瘍と脳腫瘍におけるMYCファミリー遺伝子（実験医学3月号）2018

[Journal Article] NCYM, a Cis-antisense gene of MYCN,　encodes a de novo evolved protein that inhibits GSK3β resulting in the　stabilization of MYCN in human neuroblastomas.2014

[Journal Article] ALK is a MYCN target　gene and regulates cell migration and invasion in neuroblastoma.2013