Araki Marito 荒木真理人

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ARAKI Marito 荒木真理人

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Researcher Number	80613843
Other IDs
Affiliation (Current)	2025: 順天堂大学, 大学院医学研究科, 客員教授
Affiliation (based on the past Project Information) *help	2021 – 2023: 順天堂大学, 大学院医学研究科, 客員教授 2019 – 2020: 順天堂大学, 医学(系)研究科(研究院), 先任准教授 2015 – 2018: 順天堂大学, 医学(系)研究科(研究院), 准教授 2017: 順天堂大学, 医学部輸血・幹細胞制御学, 准教授 2012: 順天堂大学, 医学(系)研究科(研究院), 准教授 2011 – 2012: 順天堂大学, 医学研究科, 准教授
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Hematology / Tumor biology Except Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Hematology / Basic Section 40040:Aquatic life science-related
Keywords	Principal Investigator calreticulin / トロンボポエチン / 分子シャペロン / 骨髄増殖性腫瘍 / カルレティキュリン / MPL / JAK2 / 抗体 / ２量体 / 受容体 … More / Calreticulin / thrombopoietin / CALR / シグナル伝達 / サイトカイン受容体 / がん性幹細胞 / 足場非依存的増殖 / がん幹細胞 / 足場非依存性 / 卵巣癌 / CD133 … More Except Principal Investigator 骨髄増殖性腫瘍 / 本態性血小板血症 / calreticulin / トロンボポエチン受容体 / 造血幹細胞 / 骨髄線維症 / JAK2 / iPS細胞 / 癌 / 診断マーカー / シグナル伝達 / レクチン / エンドサイトーシス / 小胞輸送 / 毒素 / 海洋天然物 / ドラッグデリバリー / 細胞内移行 / 抗ウイルス / タンパク毒素 / triple-negative / 治療抵抗性 / チロシンキナーゼ阻害薬 / チロシンキナーゼ阻害薬治療抵抗性 / DRP1 / ミトコンドリアの断片化 / シングルセルアナリシス / ゴーストサイトメトリー / ミトコンドリア / 白血病幹細胞 / 慢性骨髄性白血病 / サイトカイン受容体 / 翻訳後修飾 / サイトカイン / 分子シャペロン / Calreticulin / CALR / 骨髄繊維化 / 転写因子 / 小胞体ストレス / 巨核球 / 血小板 / 小胞体ストレス応答因子 / 疾患iPS細胞 / 原発性骨髄線維症 / 免疫不全マウス / 変異型CALR / 奇形腫 / カルレティキュリン / ドライバー変異 / ゲノム / 細胞 / 遺伝子 / 急性白血病 / ドライバー遺伝子 / 家族性骨髄増殖性腫瘍 / 網羅的遺伝子解析 / ゲノム編集 / iPS / CRISPR/Cas9 / JAK2V617F変異 / 薬剤反応性 / 遺伝子変異 / スタチン / JAK2遺伝子変異 / ヒドロキシウレア / 個別化治療 / non-responder / アナグレリド / 核酸 / 内科 / 疾患マーカー / 血小板増多 / 網羅的遺伝子発現解析 Less

変異型CALRを標的とした骨髄増殖性腫瘍治療法の開発Principal Investigator
- Principal Investigator
  
  荒木真理人
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Juntendo University
Exploring Marine Natural Products that Regulate Dynamic Responses of cells
- Principal Investigator
  
  酒井隆一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 40040:Aquatic life science-related
- Research Institution
  Hokkaido University
Elucidation of the mechanism of bone marrow fibrosis by focusing on the differences in tumorigenicity between mutant CALR types
- Principal Investigator
  
  今井美沙
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Juntendo University
Elucidation of receptor maturation mechanism that causes myeloproliferative neoplasms
- Principal Investigator
  
  Masubuchi Nami
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Juntendo University
Development of novel treatment strategy for TKI resistant chronic myeloid leukemia cell.
- Principal Investigator
  
  Takaku Tomoiku
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Juntendo University
Elucidate the autonomous activation mechanism of thrombopoietin receptor without genetic mutation
- Principal Investigator
  
  Yang Yinjie
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Juntendo University
Understanding the mechanism of cell tumorigenesis promoted by essential thrombocythemia specific transcriptional network
- Principal Investigator
  
  Komatsu Norio
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Juntendo University
Establishment of therapeutic concept targeting homomultimerized mutant CALRPrincipal Investigator
- Principal Investigator
  
  ARAKI MARITO
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Juntendo University
Individualized pharmacotherapy for essential thrombocythemia using pharmacogenomic information
- Principal Investigator
  
  Takahashi Harumi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Meiji Pharmaceutical University
Clarification of the pathogenesis of myeloproliferative neoplasms based on the identification of genetic factors in familial cases
- Principal Investigator
  
  Komatsu Norio
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Juntendo University
Elucidation of molecular mechanism of cytokie receptor activation by mutant CALRPrincipal Investigator
- Principal Investigator
  
  ARAKI MARITO
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Juntendo University
Establishment of in vitro model for essential thrombocythemia by mutant calreticulin
- Principal Investigator
  
  MIZUKAMI Yoshihisa
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  Juntendo University
Identification of promising marker(s) for essential thrombocythemia diagnosis by differential gene expression approach
- Principal Investigator
  
  KOMATSU Norio
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  Juntendo University
Understanding the molecular mechanism required for an anchorage-independent growth of CD133-positive ovarian cancer cellsPrincipal Investigator
- Principal Investigator
  
  ARAKI Marito
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Tumor biology
- Research Institution
  Juntendo University

All 2023 2022 2021 2020 2019 2018 2017 2016 2013 2012 2011

All Journal Article Presentation Book Patent

[Book] これからの骨髄増殖性腫瘍の基礎研究と臨床のゴール.2017
- Author(s)
  小松則夫, 桐戸敬太, 荒木真理人
- Total Pages
  14
- Publisher
  最新医学社
- Data Source
  KAKENHI-PROJECT-17H04211
[Journal Article] Non-driver gene mutation analysis in a large cohort of polycythemia vera and essential thrombocythemia2023
- Author(s)
  Morishita S, Hashimoto Y, Furuya C, Edahiro Y, Ochiai T, Shirane S, Inano T, Yasuda H, Ando M, Araki M, Komatsu N
- Journal Title
  
  European Journal of Haematology
  
  Volume: 110 Issue: 2 Pages: 131-136
- DOI
  10.1111/ejh.13882
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03715
[Journal Article] Reevaluation of cardiovascular risk factors for thrombotic events in 580 Japanese patients with essential thrombocythemia2023
- Author(s)
  Furuya C, Hashimoto Y, Morishita S, Inano T, Ochiai T, Shirane S, Edahiro Y, Araki M, Ando M, Komatsu N
- Journal Title
  
  Journal of Thrombosis and Thrombolysis
  
  Volume: 55 Pages: 263-272
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03715
[Journal Article] Establishment of isogenic induced pluripotent stem cells with or without pathogenic mutation for understanding the pathogenesis of myeloproliferative neoplasms2023
- Author(s)
  Liu Chang、Imai Misa、Edahiro Yoko、Mano Shuichi、Takei Hiraku、Nudejima Mai、Kurose Akira、Morishita Soji、Ando Miki、Tsuneda Satoshi、Araki Marito、Komatsu Norio
- Journal Title
  
  Experimental Hematology
  
  Volume: 118 Pages: 12-20
- DOI
  10.1016/j.exphem.2022.11.005
- Data Source
  KAKENHI-PROJECT-21K08376
[Journal Article] Clinical features of acquired erythrocytosis: Low levels of serum erythropoietin in a subset of non‐neoplastic erythrocytosis patients2022
- Author(s)
  Mori Yosuke、Araki Marito、Morishita Soji、Imai Misa、Edahiro Yoko、Ito Masafumi、Ochiai Tomonori、Shirane Shuichi、Hashimoto Yoshinori、Yasuda Hajime、Ando Jun、Ando Miki、Komatsu Norio
- Journal Title
  
  Cancer Medicine
  
  Volume: 12 Issue: 2 Pages: 1079-1089
- DOI
  10.1002/cam4.4958
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08376, KAKENHI-PROJECT-20H03715
[Journal Article] Phase 1 Clinical Trial of PPMX‐T003, a Novel Human Monoclonal Antibody Specific for Transferrin Receptor 1, to Evaluate Its Safety, Pharmacokinetics, and Pharmacodynamics2022
- Author(s)
  Ogama Yoichiro、Kumagai Yuji、Komatsu Norio、Araki Marito、Masubuchi Nami、Akiyoshi Hiroko、Matsuura Tadashi、Kirisako Hiromi、Kyoya Akiko、Nomura Fumiko、Ohira Yuta、Yokokawa Takuya、Yamamoto Yukiya
- Journal Title
  
  Clinical Pharmacology in Drug Development
  
  Volume: 0 Issue: 6 Pages: 1-9
- DOI
  10.1002/cpdd.1216
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08405
[Journal Article] Eliminating chronic myeloid leukemia stem cells by IRAK1/4 inhibitors2022
- Author(s)
  Tanaka Yosuke....Goyama Susumu、Komatsu Norio、Takaku Tomoiku、Kitamura Toshio
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 271-271
- DOI
  10.1038/s41467-021-27928-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03685, KAKENHI-PROJECT-19H03688, KAKENHI-PROJECT-20K06477, KAKENHI-PROJECT-21K08376, KAKENHI-PROJECT-22K19539, KAKENHI-PROJECT-20H00537
[Journal Article] A marine sponge-derived lectin reveals hidden pathway for thrombopoietin receptor activation2022
- Author(s)
  Watari Hiromi、Kageyama Hiromu、Masubuchi Nami、Nakajima Hiroya、Onodera Kako、Focia Pamela J.、Oshiro Takumi、Matsui Takashi、Kodera Yoshio、Ogawa Tomohisa、Yokoyama Takeshi、Hirayama Makoto、Hori Kanji、Freymann Douglas M.、Imai Misa、Komatsu Norio、Araki Marito、Tanaka Yoshikazu、Sakai Ryuichi
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 7262-7262
- DOI
  10.1038/s41467-022-34921-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06036, KAKENHI-PROJECT-21K08405, KAKENHI-PROJECT-21K18321, KAKENHI-PROJECT-21K19201, KAKENHI-PROJECT-22K20589, KAKENHI-PROJECT-19KK0178, KAKENHI-PUBLICLY-21H05712, KAKENHI-PROJECT-19H00918, KAKENHI-PROJECT-23K23695, KAKENHI-PROJECT-23K24176
[Journal Article] Clinical and biological relevance of CREB3L1 in Philadelphia chromosome-negative myeloproliferative neoplasms2022
- Author(s)
  De Marchi Federico、Okuda Maho、Morishita Soji、Imai Misa、Baba Terumi、Horino Mei、Mori Yosuke、Furuya Chiho、Ogata Satoko、Yang Yinjie、Ando Jun、Ando Miki、Araki Marito、Komatsu Norio
- Journal Title
  
  Leukemia Research
  
  Volume: 119 Pages: 106883-106883
- DOI
  10.1016/j.leukres.2022.106883
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08376, KAKENHI-PROJECT-21K16275, KAKENHI-PROJECT-20H03715
[Journal Article] In silico-labeled ghost cytometry2021
- Author(s)
  Ugawa M、Kawamura Y、Toda K、Teranishi K、Morita H、Adachi Hiroaki、Tamoto Ryo、Nomaru Hiroko、Nakagawa Keiji、Sugimoto Keiki、Borisova Evgeniia、An Y、Konishi Y、Tabata S、Morishita S、Imai M、Takaku T、Araki M、Komatsu N、Hayashi Y、Sato I、Horisaki R、Noji H、Ota S
- Journal Title
  
  eLife
  
  Volume: 10
- DOI
  10.7554/elife.67660
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08376
[Journal Article] MPL overexpression induces a high level of mutant-CALR/MPL complex: a novel mechanism of ruxolitinib resistance in myeloproliferative neoplasms with CALR mutations2021
- Author(s)
  Yasuda Shunichiro、Aoyama Satoru、Yoshimoto Ryoto、Li Huixin、Watanabe Daisuke、Akiyama Hiroki、Yamamoto Kouhei、Fujiwara Takeo、Najima Yuho、Doki Noriko、Sakaida Emiko、Edahiro Yoko、Imai Misa、Araki Marito、Komatsu Norio、Miura Osamu、Kawamata Norihiko
- Journal Title
  
  International Journal of Hematology
  
  Volume: 114 Issue: 4 Pages: 424-440
- DOI
  10.1007/s12185-021-03180-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08848, KAKENHI-PROJECT-19K17871
[Journal Article] MPNにおけるcalreticulin遺伝子変異の意義2021
- Author(s)
  増渕菜弥、荒木真理人、小松則夫
- Journal Title
  
  血液内科
  
  Volume: 82 Pages: 339-346
- Data Source
  KAKENHI-PROJECT-19K08848
[Journal Article] Hidden pathway for cytokine receptor activation: Structural insights into a marine sponge-derived lectin that activates the thrombopoietin receptor via recognition of the fucose moiety2021
- Author(s)
  Watari Hiromi、Kageyama Hiromu、Masubuchi Nami、Nakajima Hiroya、Onodera Kako、Focia Pamela J.、Oshiro Takumi、Matsui Takashi、Kodera Yoshio、Ogawa Tomohisa、Yokoyama Takeshi、Hirayama Makoto、Hori Kanji、Freymann Douglas M.、Komatsu Norio、Araki Marito、Tanaka Yoshikazu、Sakai Ryuichi
- Journal Title
  
  bioRixiv
  
  Volume: -
- DOI
  10.1101/2021.10.29.466502
- Open Access
- Data Source
  KAKENHI-PROJECT-21K08405, KAKENHI-PROJECT-20J11377
[Journal Article] Cell-autonomous megakaryopoiesis associated with polyclonal hematopoiesis in triple-negative essential thrombocythemia2021
- Author(s)
  Inano Tadaaki、Araki Marito、Morishita Soji、Imai Misa、Kihara Yoshihiko、Okuda Maho、Yang Yinjie、Ito Masafumi、Osaga Satoshi、Mano Hiroyuki、Edahiro Yoko、Ochiai Tomonori、Misawa Kyohei、Fukuda Yasutaka、Ando Jun、Komatsu Norio
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 17702-17702
- DOI
  10.1038/s41598-021-97106-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08848, KAKENHI-PROJECT-19K17871, KAKENHI-PROJECT-21K08376, KAKENHI-PROJECT-21K16250, KAKENHI-PROJECT-21K16275
[Journal Article] Thrombocytosis caused by abnormal molecular chaperone2020
- Author(s)
  ARAKI Marito
- Journal Title
  
  Japanese Journal of Thrombosis and Hemostasis
  
  Volume: 31 Issue: 5 Pages: 491-497
- DOI
  10.2491/jjsth.31.491
- NAID
  130007928076
- ISSN
  0915-7441, 1880-8808
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08848
[Journal Article] 変異型calreticulinによる骨髄増殖性腫瘍発症の分子基盤2020
- Author(s)
  荒木真理人
- Journal Title
  
  臨床血液
  
  Volume: 61 Pages: 937-944
- NAID
  130007897793
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08848
[Journal Article] CREB3L1 overexpression as a potential diagnostic marker of Philadelphia chromosome?negative myeloproliferative neoplasms2020
- Author(s)
  Morishita Soji、Yasuda Hajime、Yamawaki Saya、Kawaji Hideya、Itoh Masayoshi、Edahiro Yoko、Imai Misa、Kogo Yasushi、Tsuneda Satoshi、Ohsaka Akimichi、Hayashizaki Yoshihide、Ito Masafumi、Araki Marito、Komatsu Norio
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 2 Pages: 884-892
- DOI
  10.1111/cas.14763
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06690, KAKENHI-PROJECT-19K17871, KAKENHI-PROJECT-20H03715, KAKENHI-PROJECT-18K08372, KAKENHI-PROJECT-19K08848
[Journal Article] Mechanism underlying the development of myeloproliferative neoplasms through mutant calreticulin2020
- Author(s)
  Edahiro Yoko、Araki Marito、Komatsu Norio
- Journal Title
  
  Cancer Science
  
  Volume: 111 Issue: 8 Pages: 2682-2688
- DOI
  10.1111/cas.14503
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06690, KAKENHI-PROJECT-19K17871, KAKENHI-PROJECT-18K08372, KAKENHI-PROJECT-19K08848
[Journal Article] Mutant calreticulin interacts with MPL in the secretion pathway for activation on the cell surface2019
- Author(s)
  Masubuchi Nami、Araki Marito、Yang Yinjie、Hayashi Erina、Imai Misa、Edahiro Yoko、Hironaka Yumi、Mizukami Yoshihisa、Kihara Yoshihiko、Takei Hiraku、Nudejima Mai、Koike Masato、Ohsaka Akimichi、Komatsu Norio
- Journal Title
  
  Leukemia
  
  Volume: 34 Issue: 2 Pages: 499-509
- DOI
  10.1038/s41375-019-0564-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06690, KAKENHI-PROJECT-18K08372, KAKENHI-PROJECT-19K08848, KAKENHI-PROJECT-18K16098, KAKENHI-PROJECT-18K16127, KAKENHI-PROJECT-19K17871, KAKENHI-PROJECT-17H04211, KAKENHI-PROJECT-17K08522, KAKENHI-PROJECT-17K16195, KAKENHI-PROJECT-18K16126
[Journal Article] JAK2 exon 12 mutation in myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis: Not an exclusive mutation to polycythaemia vera2019
- Author(s)
  Inano, T. Araki, M. Morishita, S. Imai, M. Yasuda, H. Nitta, H. Ito, M. Edahiro, Y. Ochiai, T. Misawa, K. Fukuda, Y. Ohsaka, A. Komatsu, N.
- Journal Title
  
  British Journal of Haematology
  
  Volume: 187 Issue: 1
- DOI
  10.1111/bjh.16146
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08848, KAKENHI-PROJECT-19K17871, KAKENHI-PROJECT-17K16195
[Journal Article] MPNのゲノム解析研究の進歩2019
- Author(s)
  奥田真帆、荒木真理人、小松則夫
- Journal Title
  
  血液内科
  
  Volume: 79 Pages: 556-564
- Data Source
  KAKENHI-PROJECT-19K08848
[Journal Article] 骨髄増殖性腫瘍の遺伝子異常2019
- Author(s)
  荒木真理人、森下総司、小松則夫
- Journal Title
  
  臨床検査
  
  Volume: 63 Pages: 790-796
- Data Source
  KAKENHI-PROJECT-19K08848
[Journal Article] Clinical and molecular features of patients with prefibrotic primary myelofibrosis previously diagnosed as having essential thrombocythemia in Japan2019
- Author(s)
  Edahiro Yoko、Araki Marito、Inano Tadaaki、Ito Masafumi、Morishita Soji、Misawa Kyohei、Fukuda Yasutaka、Imai Misa、Ohsaka Akimichi、Komatsu Norio
- Journal Title
  
  European Journal of Haematology
  
  Volume: 00 Issue: 6 Pages: 1-5
- DOI
  10.1111/ejh.13236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19203, KAKENHI-PROJECT-19K08848, KAKENHI-PROJECT-19K17871
[Journal Article] Evidence for prevention of renal dysfunction associated with primary myelofibrosis by cytoreductive therapy2019
- Author(s)
  Fukuda Yasutaka、Araki Marito、Yamamoto Kouji、Morishita Soji、Inano Tadaaki、Misawa Kyohei、Ochiai Tomonori、Edahiro Yoko、Imai Misa、Yasuda Hajime、Gotoh Akihiko、Ohsaka Akimichi、Komatsu Norio
- Journal Title
  
  Haematologica
  
  Volume: 印刷中 Issue: 11 Pages: e506-e509
- DOI
  10.3324/haematol.2018.208876
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06690, KAKENHI-PROJECT-15K07972, KAKENHI-PROJECT-19K08848, KAKENHI-PROJECT-19K17871, KAKENHI-PROJECT-17K16195
[Journal Article] The role of calreticulin mutations in myeloproliferative neoplasms2019
- Author(s)
  Araki Marito、Komatsu Norio
- Journal Title
  
  International Journal of Hematology
  
  Volume: 111 Issue: 2 Pages: 200-205
- DOI
  10.1007/s12185-019-02800-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06690, KAKENHI-PROJECT-19K08848, KAKENHI-PROJECT-17H04211
[Journal Article] Mutational subtypes of JAK2 and CALR correlate with different clinical features in Japanese patients with myeloproliferative neoplasms.2018
- Author(s)
  Misawa K, Yasuda H, Araki M, Ochiai T, Morishita S, Shirane S, Edahiro Y, Gotoh A, Ohsaka A, Komatsu N.
- Journal Title
  
  Int J Hematol
  
  Volume: 印刷中 Issue: 6 Pages: 673-680
- DOI
  10.1007/s12185-018-2421-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07972, KAKENHI-PROJECT-16K09859, KAKENHI-PROJECT-18K06690, KAKENHI-PROJECT-17H04211
[Journal Article] Homomultimerization of mutant calreticulin is a prerequisite for MPL binding and activation2018
- Author(s)
  Araki Marito、Yang Yinjie、Imai Misa、Mizukami Yoshihisa、Kihara Yoshihiko、Sunami Yoshitaka、Masubuchi Nami、Edahiro Yoko、Hironaka Yumi、Osaga Satoshi、Ohsaka Akimichi、Komatsu Norio
- Journal Title
  
  Leukemia
  
  Volume: 33 Issue: 1 Pages: 122-131
- DOI
  10.1038/s41375-018-0181-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06690, KAKENHI-PROJECT-18K08372, KAKENHI-PROJECT-17K16195, KAKENHI-PROJECT-18K16098, KAKENHI-PROJECT-18K16100, KAKENHI-PROJECT-18K16126, KAKENHI-PROJECT-18K16127, KAKENHI-PROJECT-17H04211, KAKENHI-PROJECT-15K07972, KAKENHI-PROJECT-16K09859
[Journal Article] Skewed megakaryopoiesis in human induced pluripotent stem cell-derived haematopoietic progenitor cells harbouring calreticulin mutations2018
- Author(s)
  Hiraku Takei, Yoko Edahiro, Shuichi Mano, Nami Masubuchi, Yoshihsa Mizukami, Misa Imai, Soji Morishita, Kyohei Misawa, Tomonori Ochiai, Satoshi Tsuneda, Hiroshi Endo, Sou Nakamura, Koji Eto, Akimichi Ohsaka, Marito Araki, Norio Komatsu
- Journal Title
  
  British Journal of Haematology
  
  Volume: 印刷中 Issue: 6 Pages: 791-802
- DOI
  10.1111/bjh.15266
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16J11017, KAKENHI-PROJECT-18K06690, KAKENHI-PROJECT-17K16195, KAKENHI-PROJECT-18K16126, KAKENHI-PROJECT-17H04211, KAKENHI-PROJECT-15K07972, KAKENHI-PROJECT-16K09859, KAKENHI-PROJECT-18H04164
[Journal Article] The 2014 BCSH criteria and the 2016 WHO criteria for essential thrombocythemia: A comparison in a large-scale cohort.2018
- Author(s)
  Ochiai T, Yasuda H, Araki M, Misawa K, Morishita S, Nudejima M, Hironaka Y, Shirane S, Edahiro Y, Gotoh A, Ohsaka A, Komatsu N.
- Journal Title
  
  Eur J Haematol
  
  Volume: 印刷中 Issue: 6 Pages: 544-549
- DOI
  10.1111/ejh.13041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07972, KAKENHI-PROJECT-16K09859, KAKENHI-PROJECT-17H04211, KAKENHI-PROJECT-15K19559, KAKENHI-PROJECT-18K06690
[Journal Article] Skewed megakaryopoiesis in human iPS cell-derived hematopoietic progenitor cells harboring calreticulin mutations2018
- Author(s)
  Hiraku Takei, Yoko Edahiro, Shuichi Mano, Nami Masubuchi, Yoshihisa Mizukami, Misa Imai, Soji Morishita, Satoshi Tsuneda, Hiroshi Endo, Sou Nakamura, Koji Eto, Akimichi Ohsaka, Marito Araki, Norio Komatsu
- Journal Title
  
  British Journal of Haematology
  
  Volume: 印刷中
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K19587
[Journal Article] Development of myeloproliferative neoplasms by mutant calreticulin: underlying mechanisms2018
- Author(s)
  荒木真理人
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 59 Issue: 8 Pages: 1072-1077
- DOI
  10.11406/rinketsu.59.1072
- NAID
  130007472202
- ISSN
  0485-1439, 1882-0824
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09859
[Journal Article] Mutant molecular chaperone activates cytokine receptor as a homomultimer2018
- Author(s)
  Araki Marito、Komatsu Norio
- Journal Title
  
  Oncotarget
  
  Volume: 9 Issue: 81 Pages: 35201-35202
- DOI
  10.18632/oncotarget.26221
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06690, KAKENHI-PROJECT-15K07972, KAKENHI-PROJECT-16K09859
[Journal Article] Novel molecular mechanism of cellular transformation by a mutant molecular chaperone in myeloproliferative neoplasms2017
- Author(s)
  Araki Marito、Komatsu Norio
- Journal Title
  
  Cancer Sci
  
  Volume: 108 Issue: 10 Pages: 1907-1912
- DOI
  10.1111/cas.13327
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09859, KAKENHI-PROJECT-17H04211
[Journal Article] Somatic mutations of calreticulin in myeloproliferative neoplasms2017
- Author(s)
  Imai Misa、Araki Marito、Komatsu Norio
- Journal Title
  
  Int J Hematol
  
  Volume: 105 Issue: 6 Pages: 743-747
- DOI
  10.1007/s12185-017-2246-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09859, KAKENHI-PROJECT-17K16195, KAKENHI-PROJECT-17H04211
[Journal Article] The 2016 WHO diagnostic criteria for polycythemia vera renders an accurate diagnosis to a broader range of patients including masked polycythemia vera: Comparison with the 2008 WHO diagnostic criteria.2017
- Author(s)
  Misawa K, Yasuda H, Araki M, Ochiai T, Morishita S, Nudejima M, Hironaka Y, Shirane S, Edahiro Y, Gotoh A, Ohsaka A, Komatsu N.
- Journal Title
  
  Am J Hematol
  
  Volume: 92 Issue: 7
- DOI
  10.1002/ajh.24752
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07972, KAKENHI-PROJECT-16K09859, KAKENHI-PROJECT-17H04211, KAKENHI-PROJECT-15K19559
[Journal Article] 骨髄増殖性腫瘍におけるドライバー遺伝子変異による腫瘍化の分子メカニズム2017
- Author(s)
  荒木真理人
- Journal Title
  
  最新醫學
  
  Volume: 72 Pages: 1522-1528
- Data Source
  KAKENHI-PROJECT-16K09859
[Journal Article] 骨髄増殖性腫瘍を引き起こす変異型calreticulinによるTPO受容体の活性化.2016
- Author(s)
  今井美沙, 荒木真理人, 森下総司, 小松則夫.
- Journal Title
  
  血液内科
  
  Volume: 73 Pages: 789-793
- Data Source
  KAKENHI-PROJECT-16K09859
[Journal Article] 骨髄増殖性腫瘍の遺伝子変異　最近の知見.2016
- Author(s)
  荒木真理人, 森下総司, 小松則夫.
- Journal Title
  
  臨床血液.
  
  Volume: 57 Pages: 2526-2534
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09859
[Journal Article] Inhibition of the NAD-dependent protein deacetylase SIRT2 induces granulocytic differentiation in human leukemia cells2013
- Author(s)
  Yoshitaka Sunami, Marito Araki, Yumi Hironaka, Soji Morishita, Masaki Kobayashi 、 Ei Leen Liew 、 Yoko Edahiro, Miyuki Tsutsui 、 Akimichi Ohsaka, Norio Komatsu
- Journal Title
  
  PLoS One
  
  Volume: 8(2)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23800055
[Patent] 切断型の変異型Ｃａｌｒｅｔｉｃｕｌｉｎに結合する抗体、及び骨髄増殖性腫瘍の診断、予防又は治療薬2020
- Inventor(s)
  荒木真理人、小松則夫、木原慶彦
- Industrial Property Rights Holder
  荒木真理人、小松則夫、木原慶彦
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Overseas
- Data Source
  KAKENHI-PROJECT-19K08848
[Patent] 非公開2020
- Inventor(s)
  荒木真理人、小松則夫、木原慶彦
- Industrial Property Rights Holder
  荒木真理人、小松則夫、木原慶彦
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Overseas
- Data Source
  KAKENHI-PROJECT-19K08848
[Patent] 多血症治療薬2020
- Inventor(s)
  張黎臨、野村富美子、荒木真理人、小松則夫
- Industrial Property Rights Holder
  張黎臨、野村富美子、荒木真理人、小松則夫
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Overseas
- Data Source
  KAKENHI-PROJECT-19K08848
[Patent] 抗切断型変異ＣＡＬＲ－ＣＤ３二重特異性抗体及び医薬組成物2020
- Inventor(s)
  小松則夫、荒木真理人、木原慶彦、石田陽治、ほか
- Industrial Property Rights Holder
  小松則夫、荒木真理人、木原慶彦、石田陽治、ほか
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-143551
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-19K08848
[Patent] 非公開2019
- Inventor(s)
  荒木真理人、小松則夫、木原慶彦
- Industrial Property Rights Holder
  荒木真理人、小松則夫、木原慶彦
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-036119
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-16K09859
[Patent] 急性前骨髄性白血病治療薬のスクリーニング方法2012
- Inventor(s)
  荒木真理人、小松則夫、角南義孝
- Industrial Property Rights Holder
  荒木真理人、小松則夫、角南義孝
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2012-181369
- Filing Date
  2012-08-20
- Data Source
  KAKENHI-PROJECT-23800055
[Patent] 急性前骨髄性白血病治療薬のスクリーニング方法2012
- Inventor(s)
  荒木真理人、小松則夫、角南義孝
- Industrial Property Rights Holder
  荒木真理人、小松則夫、角南義孝
- Filing Date
  2012-08-20
- Data Source
  KAKENHI-PROJECT-23800055
[Presentation] MECHANISM OF CYTOKINE RECEPTOR ACTIVATION BY MARINE SPONGE LECTIN.2023
- Author(s)
  Hiromi Watari, Hiroki Kageyama, Nami Masubuchi, Marito Araki, Yoshikazu Tanaka and Ryuichi Sakai
- Organizer
  XVII MaNaPro International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23695
[Presentation] Elucidation of the molecular mechanism for the cleavage of mutant calreticulin2022
- Author(s)
  Yoshikawa S, Araki M, Lihara Y, Masubuchi M, Yang Y, Morishita S, Imai M, Ydahiro Y, Ando M, Komatsu N
- Organizer
  第84回日本血液学会
- Data Source
  KAKENHI-PROJECT-21K08376
[Presentation] Clinical relevance of CREB3L1 expression in Ph-negative MPN2022
- Author(s)
  Soji Morishita, Federico De Marchi, Maho Okuda, Misa Imai, Terumi Baba, Yosuke Mori, Chiho Furuya, Satoko Ogata, Yinjie Yang, Jun Ando, Miki Ando, Marito Araki, Norio Komatsu
- Organizer
  第84回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-20H03715
[Presentation] 海綿由来レクチンをプローブとしたサイトカイン受容体新規活性化機構の解明2022
- Author(s)
  辺浩美, 影山大夢, 中島寛弥, 小野寺かこ, 増渕菜弥, 大城拓未, 松井崇, 小寺義男, 小川智久, 平山真, 堀貫治, 横山武司, 小松則夫, 小松則夫, 荒木真理人, 荒木真理人, 田中良和, 酒井隆一
- Organizer
  天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-23K23695
[Presentation] Elucidation of the molecular mechanism for the cleavage of mutant calreticulin.2022
- Author(s)
  Shumpei Yoshikawa, Marito Araki, Yoshihiko Kihara, Nami Masubuchi, Yinjie Yang, Soji Morishita, Misa Imai, Yoko Edahiro, Miki Ando, Norio Komatsu.
- Organizer
  第84回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08424
[Presentation] Endogenous expression of MPLW515L showed a weak oncogenic capacity in UT-7/TPO cells.2022
- Author(s)
  Terumi Baba, Nami Masubuchi, Soji Morishita, Kaho Shioiri, Yoshihiko Kihara, Miki Ando, Marito Araki, Norio Komatsu.
- Organizer
  第84回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08405
[Presentation] Elucidation of the molecular mechanism for the cleavage of mutant calreticulin.2022
- Author(s)
  Shumpei Yoshikawa, Marito Araki, Yoshihiko Kihara, Nami Masubuchi, Yinjie Yang, Soji Morishita, Misa Imai, Yoko Edahiro, Miki Ando, Norio Komatsu.
- Organizer
  第84回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08405
[Presentation] Quantitative measurement of mutant calreticulin in specimens of myeloproliferative neoplasm patients2021
- Author(s)
  Satoko Ogata, Marito Araki, Yoshihiko Kihara, Maho Okuda, Soji Morishita, Misa Imai, Nami Masubuchi, Yousuke Mori, Yinjie Yang, Syunpei Yoshikawa, Tomonori Ochiai, Shuichi Shirane, Yoko Edahiro, Jun Ando, Norio Komatsu
- Organizer
  第83回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08848
[Presentation] 海洋天然物由来の新規生理活性タンパク質の構造機能解析2021
- Author(s)
  田中良和, 影山大夢, 辺ひろみ, 増渕菜弥, 中島寛也, 小野寺かこ, 松井崇, 小寺義男, 小川智久, 横山武司, 小松則夫, 荒木真理人, 酒井隆一
- Organizer
  第94回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-19K08848
[Presentation] JAK2 mutation discriminates neoplastic and non-neoplastic polycythemia.2021
- Author(s)
  Mori Y, Araki M, Morishita S, Imai M, Edahiro Y, Ito M, Ochiai T, Shirane S, Hashimoto Y, Ando J, Komatsu N
- Organizer
  第83回日本血液学会
- Data Source
  KAKENHI-PROJECT-21K08376
[Presentation] Therapeutic Potential of an Antibody Targeting the Cleaved Form of Mutant Calreticulin in Myeloproliferative Neoplasms2021
- Author(s)
  Marito Araki
- Organizer
  MPN Asia 2021 - the International Symposium on Myeloproliferative Neoplasms
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08848
[Presentation] Quantitative measurement of mutant calreticulin in specimens of myeloproliferative neoplasm patients.2021
- Author(s)
  Satoko Ogata，Marito Araki，Yoshihiko Kihara，Maho Okuda， Soji Morishita，Misa Imai，Nami Masubuchi，Yosuke Mori，Yang Yinjie，Syunpei Yoshikawa，Tomonori Ochiai，Shuichi Shirane， Yoko Edahiro，Jun Ando，Norio Komatsu.
- Organizer
  第83回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08424
[Presentation] Quantitative measurement of mutant calreticulin in specimens of myeloproliferative neoplasm patients2021
- Author(s)
  Ogata S, Araki M, Kihara Y, Okuda M, Morishita S, Imai M, Masubuchi N, Mori Y, Yang Y, Yoshikawa S, Ochiai T, Shirane S, Edahiro Y, Ando J, Komatsu N
- Organizer
  第83回日本血液学会
- Data Source
  KAKENHI-PROJECT-21K08376
[Presentation] On the mechanism of sugar-chain mediated activation of thrombopoietin receptor (MPL)2021
- Author(s)
  Hiromi Watari, Hiromu Kageyama, Hiroya Nakajima, Kako Onodera, PJ Foces, Nami Masubuchi, Takashi Matsui, Yoshio Kodera, Tomohisa Ogawa, Makoto Hirayama, Kanji Hori, Takeshi Yokoyama, Douglas Freymann, Norio Komatsu, Marito Araki, Yoshikazu Tanaka, Ryuichi Sakai
- Organizer
  第83回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08848
[Presentation] Specific expression of CREB3L1 in megakaryocyte in myeloproliferative neoplasms2021
- Author(s)
  Okuda M，Araki M，Federico D，Morishita S，Imai M，Mori Y，Horino M，Ochiai T，Shirame S，Edahiro Y，Ando J，Komatsu N
- Organizer
  第83回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-20H03715
[Presentation] Quantitative measurement of mutant calreticulin in specimens of myeloproliferative neoplasm patients.2021
- Author(s)
  Ogata S，Araki M，Kihara Y，Okuda M， Morishita S，Imai M，Masubuchi N，Mori Y，Yinjie Y，Yoshikawa S，Ochiai T，Shirane S， Edahiro Y，Ando J，Komatsu N.
- Organizer
  第83回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08405
[Presentation] Marine sponge lectin reveals the mechanism of sugar-chain mediated activation of MPL.2021
- Author(s)
  Watari H，Kageyama H，Nakajia H，Onodera K， Masubuchi N，Oshiro T，Matsui T，Kodera Y， Ogawa T，Hirayama M，Hori K，Yokoyama T， Komatsu N，Araki M，Tanaka Y， Sakai R.
- Organizer
  第83回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08405
[Presentation] Specific expression of CREB3L1 in megakaryocyte in myeloproliferative neoplasms2021
- Author(s)
  Okuda M, Araki M, Federico M, Morishita S, Imai M, Mori Y, Horino M, Ando J, Komatsu N
- Organizer
  第83回日本血液学会
- Data Source
  KAKENHI-PROJECT-21K08376
[Presentation] Distributions of typical non-driver mutations in essential thrombocythemia and polycythemia vera2021
- Author(s)
  Soji Morishita, Yoko Edahiro, Yoshinori Hashimoto, Shuichi Shirane, Tomonori Ochiai, Kyohei Misawa, Tadaaki Inano, Yasutaka Fukuda, Yosuke Mori, Chiho Furuya, Marito Araki, Jun Ando, Norio Komatsu
- Organizer
  第83回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08848
[Presentation] Therapeutic potential of an antibody targeting the cleaved form of mutant calreticulin in myeloproliferative neoplasms2020
- Author(s)
  Kihara Y, Araki M, Imai M, Mori Y, Horino M, Ogata T, Yoshikawa S, Taguchi T, Masubuchi N, Mabuchi Y, Yang Y, Fukuda Y, Morishita S, Suzuki T, Dohmae N, Shimonaka M, Akazawa C, Ohsaka A, Komatsu N.
- Organizer
  62nd Annual Meeting & Exposition of American Society of Hematology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08848
[Presentation] CREB3L1 Overexpresion Can Reliably Discriminate Ph-MPNs From Reactive Cases2020
- Author(s)
  Soji Morishita, Hajime Yasuda, Saya Yamawaki, Hideya Kawaji, Masayoshi Itoh, Yoko Edahiro, Misa Imai, Yasushi Kogo, Satoshi Tsuneda, Akimichi Ohsaka, Yoshihide Hayashizaki, Marito Araki, and Norio Komatsu
- Organizer
  The 63rd American Society of Hematology Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03715
[Presentation] Therapeutic potential of myeloproliferative neoplasms by antibody targeting mutant calreticulin2020
- Author(s)
  Kihara Y, Araki M, Imai M, Fukuda Y, Mori Y, Taguchi T, Masubuchi N, Mabuchi Y, Yang Y, Mizukami Y, Morishita S, Akazawa C, Ohsaka A, Komatsu N.
- Organizer
  第82回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08848
[Presentation] Concomitant occurrence of polyclonal hematopoiesis and cell-autonomous megakaryopoiesis in triple-negative essential thrombocythemia2020
- Author(s)
  Inano T, Araki M, Morishita S, Imai M, Kihara Y, Okuda M, Ito M, Osaga S, Yang Y, Edahiro Y, Ochiai T, Misawa K, Fukuda Y, Ohsaka A, Komatsu N.
- Organizer
  62nd Annual Meeting & Exposition of American Society of Hematology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08848
[Presentation] MPL Overexpression Induces a High Level of Mutant-Calr/MPL Complex: A Novel Mechanism of Ruxolitinib Resistance in Myeloproliferative Neoplasms with Calr Mutations2020
- Author(s)
  Yasuda S, Aoyama S, Yoshimoto R, Watanabe D, Akiyama H, Yamamoto K, Fujiwara T, Sakaida E, Edahiro Y, Imai M, Araki M, Komatsu N, Kawamata N.
- Organizer
  62nd Annual Meeting & Exposition of American Society of Hematology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08848
[Presentation] Targeting ER stress enhances inhibitory effect of ruxolitinib in mutated-CALR transfected cells2020
- Author(s)
  Moriyama M, Akahane D, Moriya S, Imai M, Araki M, Komatsu N, Miyazawa K, Gotoh A.
- Organizer
  第82回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08848
[Presentation] CREB3L1 Overexpression Can Reliably Discriminate Ph-MPNs from Reactive Cases2020
- Author(s)
  Morishita S, Yasuda H, Yamawaki S, Kawaji H, Itoh M, Edahiro Y, Imai M, Kogo Y, Tsuneda S, Akimichi Ohsaka, Hayashizaki Y, Araki M, Komatsu N.
- Organizer
  62nd Annual Meeting & Exposition of American Society of Hematology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08848
[Presentation] CREB3L1 overexpression as a novel diagnostic marker of Philadelphia-negative myeloproliferative neoplasms2020
- Author(s)
  Soji Morishita, Hajime Yasuda, Saya Yamawaki, Hideya Kawaji, Masayoshi Itoh, Yoko Edahiro, Misa Imai, Yasushi Kogo, Satoshi Tsuneda, Akimichi Ohsaka, Yoshihide Hayashizaki, Marito Araki, and Norio Komatsu
- Organizer
  The 82nd Annual Meeting of Japanese Society of Hematology
- Data Source
  KAKENHI-PROJECT-20H03715
[Presentation] Targeting calreticulin neoantigen for the treatment of myeloproliferative neoplasms2020
- Author(s)
  Araki M, Komatsu N.
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K08848
[Presentation] Overexpression of MPL causes ruxolitinib-resistance in MPN with CALR frame-shift mutations.2020
- Author(s)
  Yasuda S, Aoyama S, Yoshimoto R, Watanabe D, Yamamoto K, Fujiwara T, Edahiro Y, Imai M, Araki M, Komatsu N, Miura O, Kawamata N.
- Organizer
  第82回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08848
[Presentation] CREB3L1 overexpression as a novel diagnostic marker of myeloproliferative neoplasms2020
- Author(s)
  Morishita S, Yasuda H, Yamawaki S, Kawaji H, Itoh M, Edahiro Y, Imai M, Kogo Y, Tsuneda S, Ohsaka A, Hayashizaki Y, Araki M, Komatsu N.
- Organizer
  第82回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08848
[Presentation] Analysis of behavior of erythropoietin receptor on the cell surface in JAK2 mutant cells2020
- Author(s)
  Shioiri K, Araki M, Kitazawa S, Masubuchi N, Morishita S, Imai M, Ohsaka A, Komatsu N.
- Organizer
  第82回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08848
[Presentation] 典型的なドライバー遺伝子変異の見いだされない本態性血小板血症の特徴2020
- Author(s)
  荒木真理人, 稲野資明, 森下総司, 木原慶彦, 奥田真帆, 楊印杰, 今井美沙, 枝廣陽子, 伊藤雅文, 大佐賀智, 落合友則, 三澤恭平, 大坂顯通, 小松則夫.
- Organizer
  第30回日本サイトメトリー学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08848
[Presentation] Oncogenic activation of thrombopoietin receptor by mutant calreticulin on cell surface2019
- Author(s)
  Marito Araki、Norio Komatsu
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K08848
[Presentation] Distinctive clinical and molecular features in absolute triple-negative essential thrombocythemia2019
- Author(s)
  Tadaaki Inano、Marito Araki、Soji Morishita、Tomonori Ochiai、Kyohei Misawa、Yasutaka Fukuda、Naoko Midorikawa、Mai Nudejima、Masafumi Ito、Satoshi Osaga、Yoko Edahiro、Misa Imai、Teppei Taguchi、Maho Okuda、Akimichi Ohsaka、Norio Komatsu
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08848
[Presentation] 心筋梗塞・脳梗塞患者におけるJAK2 V617F変異の頻度.2019
- Author(s)
  筒井深雪, 森下総司, 西野隆, 枝廣陽子, 常田聡, 荒木真理人, 大坂顯通, 小松則夫.
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] JAK2 V617Fのコピー数はサイトカイン受容体の活性化に重要である.2019
- Author(s)
  北澤爽汰, 荒木真理人, 塩入香穂, 森下総司, 増渕菜弥, 馬場照美, 山本誠司, 堀内祥行, 今井美沙, 大坂顯通, 小松則夫.
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] The molecular mechanism underlying the development of myeloproliferative neoplasms by mutant calreticulin2019
- Author(s)
  Marito Araki
- Organizer
  第81回日本血液学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K08848
[Presentation] The impact of allelic burden of JAK2V617F on human hematopoietic cell differentiation.2019
- Author(s)
  枝廣陽子, 竹井拓, ChangLiu, 橳島麻衣, 森下総司, 大坂顯通, 荒木真理人, 小松則夫.
- Organizer
  第29回日本サイトメトリー学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] 分泌経路における変異型分子シャペロンとサイトカイン受容体の会合による細胞の腫瘍化2019
- Author(s)
  増渕菜弥、荒木真理人、木原慶彦、楊印杰、今井美沙、水上喜久、林英里奈、弘中由美、竹井拓、枝廣陽子、大坂顯通、小松則夫
- Organizer
  第29回日本サイトメトリー学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08848
[Presentation] 真性多血症患者由来iPS細胞におけるJAK2 V617F変異の修正.2019
- Author(s)
  枝廣陽子, 劉暢, 荒木真理人, 橳島麻衣, 森下総司, 今井美沙, 増渕菜弥, 水上喜久, 眞野修一, 竹井拓, 大坂顯通, 小松則夫.
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] 非ドライバー変異と予後予測システムDIPSS/DIPSS-plus.2019
- Author(s)
  森下総司, 落合友則, 三澤恭平, 大佐賀智, 稲野資明, 福田泰隆, 黒川安満, 枝廣陽子, 橳島麻衣, 緑川直子, 荒木真理人, 大坂顯通, 小松則夫.
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] Establishment of a mouse model for mutant CALR myeloproliferative neoplasms2019
- Author(s)
  Misa Imai、Yasutaka Fukuda、Teppei Taguchi、Kyohei Misawa、Honglian Tong、Kimi Araki、Motomi Osato、Akimichi Ohsaka、Marito Araki、Norio Komatsu
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08848
[Presentation] Mutant calreticulin interacts with MPL in the secretion pathway for the activation on cell surface.2019
- Author(s)
  Nami Masubuchi、Marito Araki、Yinjie Yang、Erina Hayashi、Misa Imai、Yoko Edahiro、Yumi Hironaka、Yoshihisa Mizukami、Yoshihiko Kihara、Masato Koike、Akimichi Ohsaka、Norio Komatsu
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08848
[Presentation] 腫瘍随伴性血管炎を合併した真性多血症.2019
- Author(s)
  福田泰隆, 枝廣陽子, 森下総司, 筒井深雪, 新田英昭, 安藤純, 荒木真理人, 小松則夫.
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] Overexpression of MPL Causes Ruxolitinib-Resistance in Myeloproliferative Neoplasms with Calreticulin Frame-Shift Mutations2019
- Author(s)
  Shunichiro Yasuda、Satoru Aoyama、Ryoto Yoshimoto、Watanabe Daisuke、Hiroki Akiyama、Yoshihiro Umezawa、Ayako Nogami、Kouhei Yamamoto、Takeo Fujiwara、Yoko Edahiro Marito Araki、Norio Komatsu、Tetsuya Fukuda、Ayako Arai、Osamu Miura、Norihiko Kawamata
- Organizer
  61th Annual Meeting & Exposition of American Society of Hematology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08848
[Presentation] 変異型特異的配列による変異型CALRの細胞内局在の規定2019
- Author(s)
  水上喜久、荒木真理人、今井美沙、林英里奈、増渕菜弥、楊印杰、木原慶彦、弘中由美、大坂顯通、小松則夫
- Organizer
  第29回日本サイトメトリー学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08848
[Presentation] 抗TfR1抗体による真性多血症内因性赤芽球コロニーの形成阻害.2019
- Author(s)
  木原慶彦, 増渕菜弥, 張黎臨, 荒木真理人, 小松則夫.
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] calreticulin変異による骨髄増殖性腫瘍発症の分子メカニズム2019
- Author(s)
  荒木真理人、楊印杰、増渕菜弥、林英里奈、水上喜久、木原慶彦、今井美沙、弘中由美、橳島麻衣、枝廣陽子、大坂顯通、小松則夫
- Organizer
  第29回日本サイトメトリー学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K08848
[Presentation] Mutations in epigenetic and splicing related genes among Japanese overt and prefibrotic primary myelofibrosis using target seuencing2019
- Author(s)
  Soji Morishita、Tomonori Ochiai、Kyohei Misawa、Tadaaki Inano、Yasutaka Fukuda、Yasumitsu Kurokawa、Yoko Edahiro、Marito Araki、Akimichi Ohsaka、Norio Komatsu
- Organizer
  The 10th JSH International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08848
[Presentation] 真正トリプルネガティブ本態性血小板血症における臨床的・分子生物学的特異性.2019
- Author(s)
  稲野資明, 荒木真理人, 森下総司, 落合友則, 三澤恭平, 福田泰隆, 緑川直子, 橳島麻衣, 伊藤雅文, 大佐賀智, 枝廣陽子, 今井美沙, 田口鉄平, 奥田真帆, 大坂顯通, 小松則夫.
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] Mutations in epigenetic and splicing related genes among japanese overt and prefibrotic primary myelofibrosis using target sequencing.2019
- Author(s)
  Morishita S, Ochiai T, Misawa K, Inano T, Fukuda Y, Kurokawa Y, Edahiro Y, Araki M, Ohsaka A, Komatsu N.
- Organizer
  The 10th JSH INTERNATIONAL SYMPOSIUM
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] Mutant specific sequence promotes accumulation of mutant CALR in the Golgi apparatus2019
- Author(s)
  Yoshihisa Mizukami、Marito Araki、Misa Imai、Erina Hayashi、Nami Masubuchi、Yinjie Yang、Yoshihiko Kihara、Yumi Hironaka、Akimichi Ohsaka、Norio Komatsu
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08848
[Presentation] Copy number of JAK2V617F modulates human hematopoietic cell differentiation.2018
- Author(s)
  Edahiro Y, Mano S, Takei H, Li L, Morishita S, Gotoh A, Tsuneda S, Ohsaka A, Araki M, Komatsu N.
- Organizer
  8th International Conference on Myeloproliferative Neoplasms
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] 受容体活性化において野生型JAK2は変異型JAK2を抑制しているようである.2018
- Author(s)
  北澤爽汰, 荒木真理人, 森下総司, 楊印杰, 今井美沙, 大坂顕通, 小松則夫.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] The molecular mechanism of oncogenic activation of thrombopoietin receptor by mutant calreticulin2018
- Author(s)
  Marito Araki
- Organizer
  The 1st MPN Summit
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] Introduction of CALR and JAK2 V617F mutations to UT-7/Epo and K562 by the CRISPR/Cas9 system.2018
- Author(s)
  Yasuda S, Aoyama S, Watanabe D, Araki M, Komatsu N, Miura O, Kawamata N.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] The Zygosity of JAK2V617F Determines the Disease Entities of Myeloproliferative Neoplasms By Modulating Erythropoiesis but Not Megakaryopoiesis.2018
- Author(s)
  Takei H, Edahiro Y, Li L, Mizukami Y, Imai M, Morishita S, Ohsaka A, Araki M, Komatsu N.
- Organizer
  ASH 60th Annual Meeting and Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] SLAMF7high CD16negative Monocytes Increase in Peripheral Blood of Patients with Myelofibrosis in Correlation with JAK2V617F Mutation2018
- Author(s)
  Maekawa T, Kato S, Okada Y, Tachi N, Teramoto M, Kawamura T, Osawa Y, Kobayashi S, Sato K, Hashimoto M, Suzu S, Usuki K, Morishita S, Araki M, Komatsu N, Kimura F.
- Organizer
  60th Annual Meeting & Exposition of American Society of Hematology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] APL細胞の分化誘導におけるATRA標的遺伝子の同定.2018
- Author(s)
  角南義孝, 荒木真理人, 山本誠司, 堀内祥行, 辻岡一也, 薫茂, 今井美沙, 森下総司, 大坂顯通, 小松則夫.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] UT-7/EpoおよびK562に対するCRISPR/Cas9法を用いたCALRおよびJAK2V617F変異の導入.2018
- Author(s)
  安田峻一郎, 青山慧, 渡邊大介, 荒木真理人, 小松則夫, 三浦修, 川又紀彦.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] トリプルネガティブ本態性血小板血症症例の臨床像と遺伝子変異.2018
- Author(s)
  稲野資明, 荒木真理人, 福田泰隆, 森下総司, 落合友則, 三澤恭平, 伊藤雅文, 山本紘司, 楊印杰, 田口鉄平, 枝廣陽子, 今井美沙, 後藤明彦, 大坂顯通, 小松則夫.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] 変異型 CALRの多量体化は MPLとの結合と活性化に必須である.2018
- Author(s)
  荒木真理人, 楊印杰, 今井美沙, 水上喜久, 木原慶彦, 角南義孝, 増渕菜弥, 枝廣陽子, 弘中由美, 大佐賀智, 大坂顯通, 小松則夫.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] 変異型分子シャペロンによるサイトカイン受容体活性化の分子メカニズム2018
- Author(s)
  荒木真理人, 小松則夫
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] JAK2V617F変異アレル数はヒト血球分化を変化させる.2018
- Author(s)
  竹井拓, 枝廣陽子, 李麗華, 水上喜久, 森下総司, 大坂顯通, 荒木真理人, 小松則夫.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] トリプルネガティブ本態性血小板血症症例の臨床像と遺伝子変異.2018
- Author(s)
  稲野資明, 荒木真理人, 福田泰隆, 森下総司, 落合友則, 三澤恭平, 伊藤雅文, 山本紘司, 楊印杰, 田口鉄平, 枝廣陽子, 今井美沙, 後藤明彦, 大坂顯通, 小松則夫.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] 細胞減少療法はPMF患者における腎機能の悪化を防止する.2018
- Author(s)
  福田泰隆, 荒木真理人, 山本紘司, 森下総司, 稲野資明, 三澤恭平, 落合友則, 枝廣陽子, 今井美沙, 後藤明彦, 大坂顯通, 小松則夫.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] 細胞減少療法はPMF患者における腎機能の悪化を防止する.2018
- Author(s)
  福田泰隆, 荒木真理人, 山本紘司, 森下総司, 稲野資明, 三澤恭平, 落合友則, 枝廣陽子, 今井美沙, 後藤明彦, 大坂顯通, 小松則夫.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] The molecular mechanism of oncogenic activation of thrombopoietin receptor by mutant calreticulin2018
- Author(s)
  Marito Araki
- Organizer
  The 3rd MPN Conference in Asia
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] 骨髄線維化を伴う骨髄異形成症候群の臨床病態および分子発症機序の解明.2018
- Author(s)
  新谷直樹, 原田浩徳, 原田結花, 飯塚弘子, 森下総司, 荒木真理人, 大坂顯通, 土岐典子, 大橋一輝, 萩原政夫, 小松則夫.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] JAK2V617F変異アレル数はヒト血球分化を変化させる.2018
- Author(s)
  竹井拓, 枝廣陽子, 李麗華, 水上喜久, 森下総司, 大坂顯通, 荒木真理人, 小松則夫.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] 変異型CALRの多量体化はMPLとの結合と活性化に必須である2018
- Author(s)
  荒木真理人, 楊印杰, 今井美沙, 水上喜久, 木原慶彦, 角南義孝, 増渕菜弥, 枝廣陽子, 弘中由美, 大佐賀智, 大坂顯通, 小松則夫
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] Boarding on the secretary pathway is required for the oncogenic property of mutant calreticulin.2018
- Author(s)
  Araki M, Masubuchi N, Hayashi E, Yang Y, Imai M, Kihara Y, Mizukami Y, Hironaka Y, Edahiro Y, Ohsaka A, Komatsu N.
- Organizer
  23rd Congress of the European Hematology Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] The Zygosity of JAK2V617F Determines the Disease Entities of Myeloproliferative Neoplasms By Modulating Erythropoiesis but Not Megakaryopoiesis2018
- Author(s)
  Takei H, Edahiro Y, Li L, Mizukami Y, Imai M, Morishita S, Ohsaka A, Araki M, Komatsu N.
- Organizer
  60th Annual Meeting & Exposition of American Society of Hematology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] Copy number of JAK2V617F modulates human hematopoietic cell differentiation2018
- Author(s)
  Edahiro Y, Mano S, Takei H, Morishita S, Tsuneda S, Ohsaka A, Araki M, Komatsu N.
- Organizer
  8th International Conference on Myeloproliferative Neoplasms
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] Wild-type JAK2 may suppress mutant JAK2 activity in cytokine receptor activation.2018
- Author(s)
  Kitazawa S, Araki M, Morishita S, Yang Y, Imai M, Ohsaka A, Komatsu N.
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] Secreted Mutant Calreticulins As Rogue Cytokines Trigger Thrombopoietin Receptor Activation Specifically in CALR Mutated Cells: Perspectives for MPN Therapy2018
- Author(s)
  Pecquet C, Araki M, et al.
- Organizer
  60th Annual Meeting & Exposition of American Society of Hematology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] Boarding on the secretary pathway is required for the oncogenic property of mutant calreticulin2018
- Author(s)
  Araki M, Masubuchi N, Hayashi E, Yang Y, Imai M, Kihara Y, Mizukami Y, Hironaka Y, Edahiro Y, Ohsaka A, Komatsu N.
- Organizer
  23rd Congress of the European Hematology Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] 変異型 CALR タンパク質の発現を制御するメカニズム.2017
- Author(s)
  木原慶彦, 荒木真理人, 楊印杰, 今井美沙, 増渕菜弥, 水上喜久, 弘中由美, 竹井拓, 枝廣陽子, 大坂顯通, 小松則夫.
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] 変異型CALRの細胞内コンパートメントへの局在がトロンボポエチン受容体の活性化に必要である.2017
- Author(s)
  Araki M, Komatsu N.
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] Localization of Mutant Calreticulin in the Golgi Apparatus Is Required for Its Oncogenic Capacity.2017
- Author(s)
  Masubuchi N, Araki M, Hayashi E, Yang Y, Imai M, Kihara Y, Mizukami Y, Hironaka Y, Takei H, Edahiro Y, Ohsaka A, Komatsu N.
- Organizer
  59th Annual Meeting of the American Society of Hematology and Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] The mechanism of the development of myeloproliferative neoplasms by mutant molecular chaperone2017
- Author(s)
  Marito Araki
- Organizer
  第79回日本血液学会学術集会シンポジウム「骨髄系腫瘍とクリニカルシーケンス」
- Invited
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] 家族性骨髄増殖性腫瘍患者からの iPS 細胞株の樹立.2017
- Author(s)
  眞野修一, 竹井拓, 森下総司, 水上喜久, 増渕菜弥, 弘中由美, 橳島麻衣 ,常田聡, 大坂顯通, 荒木真理人, 小松則夫
- Organizer
  第 79 回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K19587
[Presentation] 骨髄増殖性腫瘍に見出される変異型 CALR 蛋白質の細胞内局在2017
- Author(s)
  林英里奈, 荒木真理人, 増渕菜弥, 水上喜久, 楊印杰, 今井美沙 , 弘中由美, 竹井拓, 木原慶彦, 枝廣陽子, 大坂顯通, 小松則夫
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] Engagement of mutant calreticulin and MPL in a cellular compartment is required for MPL activation.2017
- Author(s)
  Nami Masubuchi, Marito Araki, Erina Hayashi, Yinjie Yang, Misa Imai, Yoshihisa Mizukami, Yumi Hironaka, Hiraku Takei, Soji Morishita, Yoshihiko Kihara, Yoko Edahiro, Akimichi Ohsaka, Norio Komatsu
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K19587
[Presentation] 家族性骨髄増殖性腫瘍患者からの iPS細胞株の樹立.2017
- Author(s)
  眞野修一, 竹井拓, 森下総司, 水上喜久, 増渕菜弥, 弘中由美, 橳島麻衣, 常田聡, 大坂顯通, 荒木真理人, 小松則夫.
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] Mechanisms governing the accumulation of mutant calreticulin2017
- Author(s)
  Yoshihiko Kihara, Marito Araki, Yinjie Yang, Misa Imai, Nami Masubuchi, Yoshihisa Mizukami, Yumi Hironaka, Hiraku Takei, Yoko Edahiro, Akimichi Ohsaka, Norio Komatsu
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] Engagement of mutant calreticulin and MPL in a cellular compartment is required for MPL activation2017
- Author(s)
  Nami Masubuchi, Marito Araki, Erina Hayashi, Yinjie Yang, Misa Imai Yoshihisa Mizukami, Yumi Hironaka, Hiraku Takei, Soji Morishita, Yoshihiko Kihara, Yoko Edahiro, Akimichi Ohsaka, Norio Komatsu
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] Mutant Calreticulin activates the thrombopoietin receptor in myeloproliferative neoplasms.2017
- Author(s)
  Marito Araki, Yinjie Yang, Nami Masubuchi, Yoshihisa Mizukami, Misa Imai, Erina Hayashi, Yumi Hironaka, Soji Morishita, Yoko Edahiro, Akimichi Ohsaka, Norio Komatsu
- Organizer
  The annual GAP Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] Localization of mutant calreticulin in the Golgi apparatus is required for its oncogenic capacity2017
- Author(s)
  Nami Masubuchi, Marito Araki, Erina Hayashi, Yinjie Yang, Misa Imai Yoshihiko Kihara, Yoshihisa Mizukami, Yumi Hironaka, Hiraku Takei, Yoko Edahiro, Akimichi Ohsaka, Norio Komatsu
- Organizer
  59th Annual Meeting & Exposition of American Society of Hematology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] Establishment of an in vitro model for the skewed megakaryopoiesis by calreticulin mutation in human cells2017
- Author(s)
  Hiraku Takei, Shuichi Mano, Nami Masubuchi, Yoshihisa Mizukami, Soji Morishita, Misa Imai, Yoko Edahiro, Yumi Hironaka, Mai Nudejima, Satoshi Tsuneda, Hiroshi Endo, Sou Nakamura, Koji Eto, Akimichi Ohsaka, Marito Araki, Norio Komatsu
- Organizer
  22nd Congress of the European Hematology Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] Skewed megakaryopoiesis observed in hematopoietic progenitor cells harboring calreticulin mutation.2017
- Author(s)
  Takei H, Mano S, Masubuchi N, Mizukami Y, Morishita S, Imai M, Edahiro Y, Hironaka Y, Nudejima M, Tsuneda S, Endo H, Nakamura S, Eto K, Ohsaka A, Araki M, Komatsu N.
- Organizer
  2017年度　生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-16K19587
[Presentation] カルレチキュリン変異を有する血球前駆細胞は巨核球への分化偏向性を有する.2017
- Author(s)
  竹井拓, 眞野修一, 増渕菜弥, 水上喜久, 今井美沙, 森下総司, 枝廣陽子, 弘中由美, 橳島麻衣, 常田聡, 遠藤大, 中村壮, 江藤浩之, 大坂顯通, 荒木真理人, 小松則夫.
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] A novel molecular mechanism of cellular transformation via a mutant molecular chaperone2017
- Author(s)
  Marito Araki
- Organizer
  MD Anderson Cancer Center - Tokyo Oncology Consortium Sister Institute Memorial Symposium
- Invited
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] Skewed megakaryopoiesis by mutant calreticulin is associated with increased GATA2 expression.2017
- Author(s)
  Takei H, Mano S, Masubuchi N, Mizukami Y, Imai M, Morishita S, Edahiro Y, Hironaka Y, Nudejima M, Tsuneda S, Endo H, Nakamura S, Eto K, Ohsaka A, Araki M, Komatsu N.
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K19587
[Presentation] 変異型CALRの細胞内コンパートメントへの局在がトロンボポエチン受容体の活性化に必要である2017
- Author(s)
  荒木真理人, 小松則夫
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] Establishment of an in vitro model for the skewed megakaryopoiesis by calreticulin mutation in human cells.2017
- Author(s)
  Takei H, Mano S, Masubuchi N, Mizukami Y, Morishita S, Imai M, Edahiro Y, Hironaka Y, Nudejima M, Tsuneda S, Endo H, Nakamura S, Eto K, Ohsaka A, Araki M, Komatsu N.
- Organizer
  22nd Congress of the European Hematology Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] 変異型 CALR による巨核球分化偏向性は GATA2 の発現亢進と相関している.2017
- Author(s)
  竹井拓, 眞野修一, 増渕菜弥, 水上喜久, 今井美沙, 森下総司, 枝廣陽子, 弘中由美, 橳島麻衣, 遠藤大, 中村壮, 江藤浩之, 大坂顯通, 荒木真理人, 小松則夫.
- Organizer
  第79回日本血液学会学術総会
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] Activation of the Thrombopoietin Receptor by Mutant Calreticulin in CALR-Mutant Myeloproliferative Neoplasms.2017
- Author(s)
  Araki M
- Organizer
  The Gordon Research Conference on Cell Biology of Megakaryocytes & Platelets.
- Place of Presentation
  Lucca, Italy
- Year and Date
  2017-02-26
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] Engagement of mutant calreticulin and MPL in a cellular compartment is required for MPL activation.2017
- Author(s)
  Masubuchi N, Araki M, Hayashi E, Yang Y, Imai M, Mizukami Y, Hironaka Y, Takei H, Morishita S, Kihara Y, Edahiro Y, Ohsaka A, Komatsu N.
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] Establishment of an in vitro model for the skewed megakaryopoiesis by calreticulin mutation in human cells.2017
- Author(s)
  Takei H, Mano S, Masubuchi N, Mizukami Y, Morishita S, Imai M, Edahiro Y, Hironaka Y, Nudejima M, Tsuneda S, Endo H, Nakamura S, Eto K, Ohsaka A, Araki M, Komatsu N
- Organizer
  22nd Congress European Hematology Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19587
[Presentation] Skewed megakaryopoiesis by mutant calreticulin is associated with increased GATA2 expression2017
- Author(s)
  Hiraku Takei, Shuichi Mano, Nami Masubuchi, Yoshihisa Mizukami, Misa Imai, Soji Morishita, Yoko Edahiro Yumi Hironaka Mai Nudejima Hiroshi Endo, Sou Nakamura, Koji Eto, Akimichi Ohsaka, Marito Araki, Norio Komatsu
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] 骨髄増殖性腫瘍に見出される変異型 CALR 蛋白質の細胞内局在.2017
- Author(s)
  林英里奈, 荒木真理人, 増渕菜弥, 水上喜久, 楊印杰, 今井美沙, 弘中由美, 竹井拓, 木原慶彦, 枝廣陽子, 大坂顯通, 小松則夫.
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] BCR-JAK2 陽性骨髄増殖性腫瘍.2017
- Author(s)
  筒井深雪, 後藤明彦, 森下総司, 荒木真理人, 福田泰隆, 新田英昭, 安藤純, 小松則夫.
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04211
[Presentation] The mechanism of the development of myeloproliferative neoplasms by mutant molecular chaperone2017
- Author(s)
  Marito Araki
- Organizer
  The 26th KOGO Annual Conference 2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] 骨髄増殖生腫瘍を引き起こす変異型Calreticulinの細胞内局在.2016
- Author(s)
  増渕菜弥、荒木真理人、楊印杰、弘中由美、竹井拓、森下総司、今井美沙、水上喜久、カンシン、大坂顯通、小松則夫
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K19587
[Presentation] Cell surface localization of mutant Calreticulin that induces myeloproliferative neoplasms (MPNs).2016
- Author(s)
  Masubuchi N, Araki M, Yang Y, Hironaka Y, Takei H, Morishita S, Mizukami Y, Kan S, Ohsaka A, Komatsu N.
- Organizer
  第78回日本血液学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] 骨髄増殖生腫瘍を引き起こす変異型Calreticulinの細胞内局在2016
- Author(s)
  増渕菜弥, 荒木真理人, Yinjie Yang, 弘中由美, 竹井拓, 森下総司, 今井美沙, 水上喜久, Kan Shin、大坂顯通, 小松則夫.
- Organizer
  第39回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] Activation of the thrombopoietin receptor by mutant calreticulin in CALR-mutant myeloproliferative neoplasms.2016
- Author(s)
  Araki M, Yang Y, Masubuchi N, Hironaka Y, Takei H, Morishita S, Mizukami Y, Kan S, Shirane S, Edahiro Y, Sunami Y, Ohsaka A, Komatsu N.
- Organizer
  21st Congress of the European Hematology Association.
- Place of Presentation
  Copenhagen, Denmark
- Year and Date
  2016-06-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] Mutant Calreticulin activates JAK2 by an interaction with thrombopoietin receptor in myeloproliferative neoplasm cells.2016
- Author(s)
  Araki M, Komatsu N.
- Organizer
  第75回日本癌学会学術総会.
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] Mutant Calreticulin activates the thrombopoietin receptor in myeloproliferative neoplasms.2016
- Author(s)
  Araki M, Yang Y, Masubuchi N, Hironaka Y, Takei H, Morishita S, Mizukami Y, Kan S, Shirane S, Edahiro Y, Sunami Y, Ohsaka A, Komatsu N.
- Organizer
  第78回日本血液学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] Modeling MPN phenotypes in vitro by using iPSC harboring CALR ins5 mutation,2016
- Author(s)
  Takei H, Masubuchi N, Mano S, Araki M, Morishita S, Mizukami Y, Kan S, Edahiro Y, Sunami Y, Hironaka Y, Endo H, Nakamura S, Eto K, Osaka A, Komatsu N
- Organizer
  第78回日本血液学会
- Place of Presentation
  横浜
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K19587
[Presentation] Modeling MPN phenotypes in vitro by using iPSC harboring CALR ins5 mutation.2016
- Author(s)
  Takei H, Masubuchi N, Mano S, Araki M, Morishita S, Mizukami Y, Kan S, Edahiro Y, Sunami Y, Hironaka Y, Endo H, Nakamura S, Eto K, Ohsaka A, Komatsu N.
- Organizer
  第78回日本血液学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K09859
[Presentation] Activation of the thrombopoietin receptor by mutant calreticulin in CALR-mutant myeloproliferative neoplasms2016
- Author(s)
  Araki M, Yang Y, Masubuchi N, Hironaka Y, Takei H, Morishita S, Mizukami Y, Kan S, Shirane S, Edahiro Y, Sunami Y, Ohsaka A, Komatsu N
- Organizer
  21st Congress European hematology association
- Place of Presentation
  Copenhagen
- Year and Date
  2016-06-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19587
[Presentation] Cell surface localization of mutant calreticulin that induces myeloproliferative neoplasms (MPNs)2016
- Author(s)
  Masubuchi N, Araki M, Yang Y, Hironaka Y, Takei H, Morishita S, Mizukami Y, Kan S, Ohsaka A, Komatsu N
- Organizer
  第78回日本血液学会
- Place of Presentation
  横浜
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K19587
[Presentation] Mutant calreticulin activate the thrombopoietin receptor in myeloproliferative neoplasm2016
- Author(s)
  Araki M, Yang Y, Masubuchi N, Hironaka Y, Takei H, Morishita S, Mizukami Y, Kan S, Shirane S, Edahiro Y, Sunami Y, Ohsaka A, Komatsu N.
- Organizer
  第78回日本血液学会
- Place of Presentation
  横浜
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K19587
[Presentation] The SirT1 Inhibitor Tenovin-6 Induces Monocytic Differentiation in APL Cells2011
- Author(s)
  角南義孝、荒木真理人, 他
- Organizer
  53回米国血液学会(53rd.ASH annual meeting)
- Place of Presentation
  サンディエゴ
- Year and Date
  2011-12-10
- Data Source
  KAKENHI-PROJECT-23800055

1. KOMATSU Norio (50186798)

# of Collaborated Projects: 11 results

# of Collaborated Products: 134 results
2. 今井美沙 (50709003)

# of Collaborated Projects: 5 results

# of Collaborated Products: 14 results
3. 森下総司 (10635866)

# of Collaborated Projects: 4 results

# of Collaborated Products: 47 results
4. Takahashi Harumi (20211344)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. MIZUKAMI Yoshihisa (30756698)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
6. Masubuchi Nami (00791641)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
7. Takaku Tomoiku (20408256)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Yang Yinjie (90808643)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. 河合純 (30391923)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 堂前直 (00321787)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 酒井隆一 (20265721)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. 高田礼人 (10292062)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 田中良和 (20374225)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
14. 松井崇 (30463582)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
15. 松本健 (60222311)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 八代田陽子 (60360658)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. ITO akihiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
18. 後藤明彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
19. 合山進

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 横山武司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Araki Marito 荒木 真理人

ARAKI Marito 荒木 真理人

Research Projects

Research Products

Co-Researchers

変異型CALRを標的とした骨髄増殖性腫瘍治療法の開発Principal Investigator

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Establishment of therapeutic concept targeting homomultimerized mutant CALRPrincipal Investigator

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Elucidation of molecular mechanism of cytokie receptor activation by mutant CALRPrincipal Investigator

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Understanding the molecular mechanism required for an anchorage-independent growth of CD133-positive ovarian cancer cellsPrincipal Investigator

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[Book] これからの骨髄増殖性腫瘍の基礎研究と臨床のゴール.2017

Araki Marito 荒木真理人

ARAKI Marito 荒木真理人