Shiota Tomoyuki 塩田智之

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SHIOTA Tomoyuki 塩田智之

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Researcher Number	80616144
Affiliation (Current)	2025: 公益財団法人神戸医療産業都市推進機構, その他部局等, 研究員(上席・主任研究員クラス)
Affiliation (based on the past Project Information) *help	2022 – 2024: 公益財団法人神戸医療産業都市推進機構, その他部局等, 研究員(上席・主任研究員クラス) 2023: 公益財団法人神戸医療産業都市推進機構, その他部局等, 研究員 2018: 国立感染症研究所, ウイルス第二部, リサーチ・レジデント 2015 – 2017: 国立感染症研究所, ウイルス第二部, リサーチレジデント 2014: 国立感染症研究所, その他部局等, 任期付研究員 2012 – 2014: 国立感染症研究所, ウイルス第二部, 任期付研究員
Review Section/Research Field	Principal Investigator Basic Section 49060:Virology-related / Virology Except Principal Investigator Basic Section 49060:Virology-related / Medium-sized Section 49:Pathology, infection/immunology, and related fields
Keywords	Principal Investigator HEV感受・非感受性細胞 / リピドミクス解析 / レプリケーションコンパートメント / A型肝炎ウイルス(HAV) / 脂肪酸取込酵素 / 脂肪酸伸長酵素 / 脂肪酸合成酵素 / RNAseq解析 / 極長鎖脂肪酸 / A型肝炎ウイルス … More / CRISPR/Cas9 / 結合・感染阻害 / 免疫沈降法 / Fc融合タンパク質 / CRIPR/Cas9 / 感受性復帰 / ゲノム編集 / 感染阻害 / non-envelope HEV / HEV非感受性細胞 / ウイルス様中空粒子（VLP） / 共免疫沈降 / 細胞外領域欠損変異体 / non-envelope形態 / 機能獲得・損失実験 / 膜タンパク質 / レセプター（ウイルス受容体） / E型肝炎ウイルス（HEV） / receptor candidate / non-enveloped HEV / hepatitis E virus (HEV) / 感染性規定宿主因子 / 非感受性細胞 / 感受性細胞 / 侵入 / 吸着 / 肝細胞 / E型肝炎ウイルス / HEV感受・非感受性細胞間の多様な遺伝子発現差 / HEV感受・非感受性細胞の網羅的遺伝子発現解析 / HEV感受性細胞cDNAライブラリ作製 / E型肝炎ウイルス（HEV）へのパンニング法の応用 / 相互作用因子 / ペプチドモチーフ / HEV感染阻害評価系 / HEV高速増殖能獲得馴化細胞株 / レセプター候補安定発現HEV非感受性細胞 / HEV 非感受性細胞 / HEVレセプター候補 / E型肝炎ウイルス（HEV) / 感染能 / 結合能 / レセプター候補 / cDNAライブラリスクリーニング / プロテオーム解析 / 網羅的遺伝子発現解析 / E型肝炎ウイルス(HEV) … More Except Principal Investigator ウイルス複製 / B型肝炎 / ウイルス / マウスモデル / B型肝炎ウイルス / 慢性肝炎 / ジェノタイプ / 肝細胞がん / ウイルス発癌 / 肝細胞癌 / 慢性感染 / 発癌 / chronic infection / HCC / Hepatitis B virus / 発ガン / 遺伝子型 / 動物モデル / host factors / tropism / mouse / hepatitis B virus / 感染受容体 Less

肝炎ウイルス特異的脂肪酸合成促進による複製複合体形成と肝病態への寄与の解明Principal Investigator
- Principal Investigator
  
  塩田智之
- Project Period (FY)
  2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Foundation for Biomedical Research and Innovation at Kobe
Lipid Reprogramming Mechanism of Hepatitis VirusPrincipal Investigator
- Principal Investigator
  
  塩田智之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Foundation for Biomedical Research and Innovation at Kobe
Development of mouse hepatocyte permissive to HBV infection
- Principal Investigator
  
  村松正道
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Foundation for Biomedical Research and Innovation at Kobe
  National Institute of Infectious Diseases
Why genotype C HBV causes liver cancer more rapidly than other genotypes?
- Principal Investigator
  
  村松正道
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Foundation for Biomedical Research and Innovation at Kobe
  National Institute of Infectious Diseases
Analysis of mechanism for an attachment and entry of hepatitis E virus for the hepatocytePrincipal Investigator
- Principal Investigator
  
  Shiota Tomoyuki
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  National Institute of Infectious Diseases
The study of attachment and entry mechanism of hepatitis E virus into hepatocytePrincipal Investigator
- Principal Investigator
  
  SHIOTA Tomoyuki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  National Institute of Infectious Diseases

All 2023 2022 2019 2018 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] Hepatoviruses promote very-long-chain fatty acid and sphingolipid synthesis for viral RNA replication and quasi-enveloped virus release2023
- Author(s)
  Shiota Tomoyuki、Li Zhucui、Chen Guan-Yuan、McKnight Kevin L.、Shirasaki Takayoshi、Yonish Bryan、Kim Heyjeong、Fritch Ethan J.、Sheahan Timothy P.、Muramatsu Masamichi、Kapustina Maryna、Cameron Craig E.、Li You、Zhang Qibin、Lemon Stanley M.
- Journal Title
  
  Science Advances
  
  Volume: 9 Issue: 42 Pages: 42-42
- DOI
  10.1126/sciadv.adj4198
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07111
[Journal Article] Detection of Subgenotype IA and IIIA Hepatitis A Viruses in Rivers Flowing through Metro Manila, the Philippines2019
- Author(s)
  Bai Huimin、Shiota Tomoyuki、Yoshizaki Sayaka、Saito-Obata Mariko、Malbas, Jr Fedelino F.、Lupisan Socorro P.、Oshitani Hitoshi、Takeda Naokazu、Muramatsu Masamichi、Wakita Takaji、Ishii Koji、Li Tian-Cheng
- Journal Title
  
  Jpn J Infect Dis
  
  Volume: 72 Issue: 1 Pages: 53-55
- DOI
  10.7883/yoken.JJID.2018.148
- NAID
  130007577801
- ISSN
  1344-6304, 1884-2836
- Year and Date
  2019-01-31
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08090, KAKENHI-PROJECT-16K08825, KAKENHI-PROJECT-15K19118
[Journal Article] Evaluation of Heating Conditions for Inactivation of Hepatitis E Virus Genotypes 3 and 4.2018
- Author(s)
  IMAGAWA T, SUGIYAMA R, SHIOTA T, LI TC, YOSHIZAKI S, WAKITA T, AND ISHII K.
- Journal Title
  
  Journal of Food Protection
  
  Volume: 81(6) Issue: 6 Pages: 947-952
- DOI
  10.4315/0362-028x.jfp-17-290
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08090, KAKENHI-PROJECT-15K19118, KAKENHI-PROJECT-26860309, KAKENHI-PROJECT-16K08825
[Journal Article] 「FSA-EFSA 食品媒介ウイルスに関するワークショップ」への参加報告Attendance Summary Report of the FSA-EFSA Workshop on Foodborne Viruses 20162016
- Author(s)
  染谷雄一、塩田智之、神谷元
- Journal Title
  
  食品衛生研究
  
  Volume: 12月号 Pages: 7-15
- Data Source
  KAKENHI-PROJECT-15K19118
[Journal Article] Establishment of hepatitis E virus infection-permissive and -non-permissive human hepatoma PLC/PRF/5 subclones2015
- Author(s)
  Tomoyuki Shiota, Tian-Cheng Li, Sayaka Yoshizaki, Takanobu Kato, Takaji Wakita and Koji Ishii
- Journal Title
  
  Microbiology and Immunology
  
  Volume: 59(2) Issue: 2 Pages: 89-94
- DOI
  10.1111/1348-0421.12219
- NAID
  40020388179
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24790452, KAKENHI-PROJECT-25460580
[Journal Article] Molecular detection of Hepatitis E virus in rivers in the Philippines2014
- Author(s)
  Tian-Cheng Li, Tingting Yang, Tomoyuki Shiota, Sayaka Yoshizaki, Hiromu Yoshida, Mariko Saito, Toshifumi Imagawa, Fidelino F. Malbas, Socorro P. Lupisan, Hitoshi Oshitani, Takaji Wakita, and Koji Ishii
- Journal Title
  
  American Journal of Tropical Medicine & Hygiene
  
  Volume: 90(4) Issue: 4 Pages: 764-766
- DOI
  10.4269/ajtmh.13-0562
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24790452, KAKENHI-PROJECT-25460580
[Journal Article] The hepatitis e virus capsid C-terminal region is essential for the viral life cycle: implication for viral genome encapsidation and particle stabilization.2013
- Author(s)
  Tomoyuki Shiota, Tiang-Cheng Li, Sayaka Yoshizaki, Takaji Wakita, and Koji Ishii.
- Journal Title
  
  Journal of Virology
  
  Volume: Epub ahead of print
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790452
[Journal Article] The hepatitis E virus capsid C-terminal region is essential for the viral life cycle: implication for viral genome encapsidation and particle stabilization2013
- Author(s)
  Shiota T, Li TC, Yoshizaki S, Kato T, Wakita T, Ishii K
- Journal Title
  
  J Virol.
  
  Volume: 87(10): Issue: 10 Pages: 6031-6036
- DOI
  10.1128/jvi.00444-13
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-24115003, KAKENHI-PROJECT-24790452, KAKENHI-PROJECT-25460580
[Presentation] A型肝炎ウイルスは脂質代謝を再構成することでウイルスRNA合成に必要な極長鎖脂肪酸合成を促進する2023
- Author(s)
  塩田智之
- Organizer
  第70回日本ウイルス学会
- Data Source
  KAKENHI-PROJECT-22K07111
[Presentation] A型肝炎ウイルスは脂質代謝を再構成しウイルスRNA複製に必要な極長鎖脂肪酸合成を促進する2023
- Author(s)
  塩田智之
- Organizer
  第72回肝炎ウイルスセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-22K07111
[Presentation] Hepatitis A virus re-wires lipid metabolism to promote very-long chain fatty acid (VLCFA) synthesis required for viral RNA replication2022
- Author(s)
  Tomoyuki Shiota
- Organizer
  Europic 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07111
[Presentation] Low-density lipoprotein receptor (LDLR) is an entry factor for naked hepatovirus (nHAV)2022
- Author(s)
  Tomoyuki Shiota
- Organizer
  Europic 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07111
[Presentation] Investigation of heat conditions to inactivate hepatitis E virus2017
- Author(s)
  Ryuichi Sugiyama, Toshifumi Imagawa, Tomoyuki Shiota, Tian-Cheng Li, Sayaka Yoshizaki, Takaji Wakita, Koji Ishii
- Organizer
  The 65th Annual Meeting of the Japanese Society for Virology
- Data Source
  KAKENHI-PROJECT-15K19118
[Presentation] Molecular characterization of the hepatitis E virus receptor candidate (E型肝炎ウイルスレセプター候補の分子特性)2016
- Author(s)
  Tomoyuki Shiota, Tian-Cheng Li, Sayaka Yoshizaki, Yorihiro Nishimura, Hiroyuki Shimizu, Masayuki Shimojima, Masayuki Saijo, Takaji Wakita, Koji Ishii.
- Organizer
  第64回日本ウイルス学会学術集会
- Place of Presentation
  札幌コンベンションセンター
- Data Source
  KAKENHI-PROJECT-15K19118
[Presentation] Characterization of a hepatitis E virus receptor candidate2016
- Author(s)
  3.Tomoyuki Shiota, Tian-Cheng Li, Sayaka Yoshizaki, Yorihiro Nishimura, Hiroyuki Shimizu, Masayuki Shimojima, Masayuki Saijo, Takaji Wakita, Koji Ishii.
- Organizer
  HCV2016 - 23rd International Symposium on Hepatitis C Virus and Related Viruses
- Place of Presentation
  Kyoto International Conference Center
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19118
[Presentation] Toward the identification of hepatitis E virus receptor (E型肝炎ウイルスの受容体同定を目指して)2016
- Author(s)
  Tomoyuki Shiota
- Organizer
  AMEDリサーチ・レジデント講演会
- Place of Presentation
  AMED20階201会議室
- Invited
- Data Source
  KAKENHI-PROJECT-15K19118
[Presentation] International Workshop on Foodborne Viruses (FSA,EFSAロンドン会議)報告2016
- Author(s)
  染谷雄一、塩田智之、神谷元.
- Organizer
  食品安全委員会微生物・ウイルス専門調査会(第66回)
- Place of Presentation
  食品安全委員会中会議室
- Invited
- Data Source
  KAKENHI-PROJECT-15K19118
[Presentation] The validation study of Hepatitis E virus receptor （E型肝炎ウイルス受容体候補の妥当性検証）2015
- Author(s)
  塩田智之、李天成、吉崎佐矢香、西村順裕、清水博之、下島昌幸、西條政幸、脇田隆字、石井孝司
- Organizer
  第63回日本ウイルス学会学術集会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-15K19118
[Presentation] Searching for the host factors involved in hepatitis E virus infection2014
- Author(s)
  Tomoyuki Shiota
- Organizer
  2014 MGH-UTokyo Symposium: Frontiers in Biomedical Engineering (Celebrating the 10th year of MGH-UTokyo Summer Student Internship Program)
- Place of Presentation
  Simches Conference Room 3110, MGH, Boston, MA, USA
- Year and Date
  2014-09-24
- Invited
- Data Source
  KAKENHI-PROJECT-24790452
[Presentation] E型肝炎ウイルスレプリコンの構築とレプリコン包埋VLP作成の検討2013
- Author(s)
  石井孝司, 李　天成, 吉崎佐矢香, 塩田智之, 脇田隆字
- Organizer
  第61回日本ウイルス学会学術集
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-24790452
[Presentation] E型肝炎ウイルス感染性規定宿主因子の探索に関する研究2013
- Author(s)
  塩田智之, 李天成, 吉崎佐矢香, 西村順裕, 清水博之, 下島昌幸, 西條政幸, 脇田隆字, 石井孝司
- Organizer
  第61回日本ウイルス学会学術集
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-24790452
[Presentation] Characterization of Hepatitis E Virus Capsid C-terminal 52 Amino Acids in the Viral Life-Cycle2012
- Author(s)
  Tomoyuki Shiota, Tiang-Cheng Li, Sayaka Yoshizaki, Naokazu Takeda, Takaji Wakita, and Koji Ishii
- Organizer
  The 34th Naito Conference on Infection, Immunity and their Control for Health: Mucosal Barrier, Pathogen and Vaccine
- Place of Presentation
  北海道札幌市
- Data Source
  KAKENHI-PROJECT-24790452
[Presentation] Characterization of Hepatitis E Virus Capsid C-terminal 52 Amino Acids in the Viral Life-Cycle2012
- Author(s)
  Tomoyuki Shiota, Tiang-Cheng Li, Sayaka Yoshizaki, Naokazu Takeda, Takaji Wakita, and Koji Ishii
- Organizer
  The 11th Awaji International Forum on Infection and Immunity
- Place of Presentation
  兵庫県淡路市
- Data Source
  KAKENHI-PROJECT-24790452
[Presentation] E型肝炎ウイルス生活環におけるカプシド蛋白C末端52アミノ酸の機能解析2012
- Author(s)
  塩田智之, 李天成, 吉崎佐矢香, 武田直和, 脇田隆字, 石井孝司
- Organizer
  第60回日本ウイルス学会
- Place of Presentation
  大阪府大阪市
- Data Source
  KAKENHI-PROJECT-24790452
[Presentation] E型肝炎ウイルス感染性規定宿主因子候補に関する研究
- Author(s)
  塩田智之、李天成、吉崎佐矢香、西村順裕、清水博之、下島昌幸、西條政幸、脇田隆字、石井孝司
- Organizer
  第62回日本ウイルス学会学術集会
- Place of Presentation
  パシフィコ横浜,神奈川
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-24790452

1. 村松正道 (20359813)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
2. 若江亨祥 (70638303)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 加藤孝宣 (20333370)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 五十川正記 (50723201)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 脇田隆字

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 李天成

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shiota Tomoyuki 塩田 智之

SHIOTA Tomoyuki 塩田 智之

Research Projects

Research Products

Co-Researchers

肝炎ウイルス特異的脂肪酸合成促進による複製複合体形成と肝病態への寄与の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Lipid Reprogramming Mechanism of Hepatitis VirusPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of mouse hepatocyte permissive to HBV infection

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Why genotype C HBV causes liver cancer more rapidly than other genotypes?

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of mechanism for an attachment and entry of hepatitis E virus for the hepatocytePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The study of attachment and entry mechanism of hepatitis E virus into hepatocytePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Hepatoviruses promote very-long-chain fatty acid and sphingolipid synthesis for viral RNA replication and quasi-enveloped virus release2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Detection of Subgenotype IA and IIIA Hepatitis A Viruses in Rivers Flowing through Metro Manila, the Philippines2019

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Evaluation of Heating Conditions for Inactivation of Hepatitis E Virus Genotypes 3 and 4.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 「FSA-EFSA 食品媒介ウイルスに関するワークショップ」への参加報告Attendance Summary Report of the FSA-EFSA Workshop on Foodborne Viruses 20162016

Author(s)

Journal Title

Data Source

[Journal Article] Establishment of hepatitis E virus infection-permissive and -non-permissive human hepatoma PLC/PRF/5 subclones2015

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Molecular detection of Hepatitis E virus in rivers in the Philippines2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The hepatitis e virus capsid C-terminal region is essential for the viral life cycle: implication for viral genome encapsidation and particle stabilization.2013

Author(s)

Journal Title

Data Source

[Journal Article] The hepatitis E virus capsid C-terminal region is essential for the viral life cycle: implication for viral genome encapsidation and particle stabilization2013

Shiota Tomoyuki 塩田智之

SHIOTA Tomoyuki 塩田智之