INOUE DAICHI 井上大地

… Alternative Names

Inoue Daichi 井上大地

井上大地イノウエダイチ

Less

Researcher Number	80735746
Other IDs	https://orcid.org/0000-0002-7947-6540
Affiliation (Current)	2025: 大阪大学, 大学院生命機能研究科, 教授 2025: 公益財団法人神戸医療産業都市推進機構, その他部局等, 研究員(副センター長・部長クラス)
Affiliation (based on the past Project Information) *help	2024: 大阪大学, 大学院生命機能研究科, 教授 2020 – 2024: 公益財団法人神戸医療産業都市推進機構, その他部局等, 研究員(副センター長・部長クラス) 2020: 公益財団法人神戸医療産業都市推進機構, その他部局等, 研究員(上席・主任研究員クラス) 2017: 東京大学, 医科学研究所, 特任助教 2014 – 2015: 東京大学, 医科学研究所, 特任助教
Review Section/Research Field	Principal Investigator Medium-sized Section 54:Internal medicine of the bio-information integration and related fields / Transformative Research Areas, Section (III) / Medium-sized Section 50:Oncology and related fields / Basic Section 54010:Hematology and medical oncology-related / Hematology Except Principal Investigator Basic Section 52040:Radiological sciences-related / Basic Section 49010:Pathological biochemistry-related / Transformative Research Areas, Section (III) / Medium-sized Section 54:Internal medicine of the bio-information integration and related fields / Hematology
Keywords	Principal Investigator 造血幹細胞 / RNAスプライシング / 急性骨髄性白血病 / 骨髄異形成症候群 / スプライシング / クロマチン記憶 / 多細胞システム / シングルセル解析 / RNA輸送 / フェロトーシス … More / セレノプロテイン / 細胞死 / RNAメチル化 / 転写後制御 / 白血病 / 逆行性解析 / ストレス / 適応多様性 / PTEN / マイナーイントロン / 遺伝子変異 / 細胞分化 / クロマチン制御 / クロマチン / CTCF / クロマチンリモデリング / SWI/SNF複合体 / BRD9 / 骨芽細胞 / クローン性造血 / エキソソーム / 間葉系幹細胞 / MDS / 細胞外小胞 / 形質転換 / TGFβ / エピジェネティクス … More Except Principal Investigator クローン性造血 / ASXL1 / MDS / ロングリード・シーケンス / 化学放射線療法 / 食道扁平上皮癌 / ロングリードRNAシーケンス / SRSF2 / SF3B1 / スプライシング異常 / ネオ抗原 / TCR-T / がん免疫 / RNAスプライシング / 細胞間相互作用 / 細胞動態計測 / 細胞多様性 / 環境適応 / スプライシング / 骨髄異形成症候群 / PPI / 造血器腫瘍 / ノックインマウス / 遺伝子 / 骨髄異形性症候群 / 骨髄ストローマ細胞 / ABC-G2 / 白血病 / EZH2 / エピジェネティクス Less

「適応多様性」研究領域の拡大・発展に向けた総括研究
- Principal Investigator
  
  諸石寿朗
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Kumamoto University
生体イベントにおける造血幹細胞の「適応多様性」の解明Principal Investigator
- Principal Investigator
  
  井上大地
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Osaka University
新次元の単一細胞解析が駆動する骨髄造血系の統合的理解Principal Investigator
- Principal Investigator
  
  井上大地
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  Osaka University
転写後制御機構の観点からみる造血異常と治療応用Principal Investigator
- Principal Investigator
  
  井上大地
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  Foundation for Biomedical Research and Innovation at Kobe
Cancer immune therapeutics targeting aberrant RNA splicing products
- Principal Investigator
  
  網代将彦
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  National Cancer Center Japan
転写産物のロングリード・シーケンスによる食道癌化学放射線療法抵抗性獲得機構の解明
- Principal Investigator
  
  平木嘉樹
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Kyushu University
Clarifying Regulatory System of Minor Introns through Evolution and Cancer DevelopmentPrincipal Investigator
- Principal Investigator
  
  Inoue Daichi
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Foundation for Biomedical Research and Innovation at Kobe
Elucidation of hematopoietic dysfunction via extracellular vesicles and its therapeutic applicationPrincipal Investigator
- Principal Investigator
  
  Inoue Daichi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  Foundation for Biomedical Research and Innovation at Kobe
Studies of MDS pathogenesis and its relation to novel therapeutic strategies
- Principal Investigator
  
  KITAMURA TOSHIO
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  The University of Tokyo
Elucidation of MDS pathogenesis based on understanding the roles of newly identified SWI/SNF complexPrincipal Investigator
- Principal Investigator
  
  Inoue Daichi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Foundation for Biomedical Research and Innovation at Kobe
Comprehensive elucidation of MDS (myelodysplastic syndromes) pathogenesis
- Principal Investigator
  
  Kitamura Toshio
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
The role of SETBP1 mutation in leukemic transformationPrincipal Investigator
- Principal Investigator
  
  Inoue Daichi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo

All 2024 2023 2022 2021 2020 2018 2017 2016 2015 2014

All Journal Article Presentation Patent

[Journal Article] Minor introns impact on hematopoietic malignancies2024
- Author(s)
  Nishimura Koutarou、Saika Wataru、Inoue Daichi
- Journal Title
  
  Experimental Hematology
  
  Volume: 132 Pages: 104173-104173
- DOI
  10.1016/j.exphem.2024.104173
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23KJ1147, KAKENHI-PROJECT-22K19475
[Journal Article] Extracellular vesicle-mediated remodeling of the bone marrow microenvironment in myeloid malignancies2023
- Author(s)
  Hayashi Yasutaka、Nishimura Koutarou、Tanaka Atsushi、Inoue Daichi
- Journal Title
  
  International Journal of Hematology
  
  Volume: 117 Issue: 6 Pages: 821-829
- DOI
  10.1007/s12185-023-03587-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20J01911, KAKENHI-PROJECT-20K21622, KAKENHI-PROJECT-21K20936, KAKENHI-PROJECT-21K16258
[Journal Article] BRD9 determines the cell fate of hematopoietic stem cells by regulating chromatin state2023
- Author(s)
  Xiao Muran、、、、Yokoyama Akihiko、、、、、Inoue Daichi
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 1-22
- DOI
  10.1038/s41467-023-44081-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0119, KAKENHI-PROJECT-21K08385, KAKENHI-PROJECT-20H03717, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-22H00455, KAKENHI-PROJECT-23K24368
[Journal Article] Dysregulated minor intron splicing in cancer.2022
- Author(s)
  Nishimura K*, Yamazaki H*, Zang W, Inoue D.
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 9 Pages: 2934-2942
- DOI
  10.1111/cas.15476
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08432, KAKENHI-PROJECT-22K19475, KAKENHI-PROJECT-21K20936, KAKENHI-PROJECT-20H03717
[Journal Article] MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis.2022
- Author(s)
  Hayashi Y, Inoue D, et al.
- Journal Title
  
  Cell Reports
  
  Volume: VOLUME 39, ISSUE 6 Issue: 6 Pages: 110805-110805
- DOI
  10.1016/j.celrep.2022.110805
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21622, KAKENHI-PROJECT-22K19539, KAKENHI-PROJECT-21K16258, KAKENHI-PROJECT-20H00537, KAKENHI-PROJECT-20H03711, KAKENHI-PROJECT-21H02711, KAKENHI-PROJECT-20J01911, KAKENHI-PROJECT-19K10024, KAKENHI-PROJECT-18KK0449, KAKENHI-PROJECT-20H03717, KAKENHI-PROJECT-21H02954
[Journal Article] Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation2022
- Author(s)
  Chen Sisi, Inoue Daichi, Abdel-Wahab Omar et al.
- Journal Title
  
  Cancer Discovery
  
  Volume: 12 Issue: 10 Pages: 2434-2453
- DOI
  10.1158/2159-8290.cd-21-1631
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03717
[Journal Article] Impaired osteoblastic differentiation of MSCs suppresses normal hematopoiesis in MDS.2022
- Author(s)
  Hayashi, Y., Kawabata, K.C., Tanaka, Y., Uehara, Y., Kiryu, S., Ota, Y., Yoshioka, Y., Mabuchi, Y., Sugiyama, T., Mikami, K., Tamura, M., Fukushima, T., Asada, S., Takeda, R., Kunisaki, Y., Fukuyama, T., Goyama, S., Yokoyama, K., Tojo, A., Katayama, Y., Arai, F., Nagasawa, T., Ochiya, T., Inoue, D., and Kitamura, T.
- Journal Title
  
  Cell Rep
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H00537
[Journal Article] Aberrant <i>EVI1</i> splicing contributes to <i>EVI1</i>-rearranged leukemia2022
- Author(s)
  Tanaka Atsushi、Kunimoto Hiroyoshi et al.
- Journal Title
  
  Blood
  
  Volume: 140 Issue: 8 Pages: 875-888
- DOI
  10.1182/blood.2021015325
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08400, KAKENHI-PROJECT-21K08432, KAKENHI-PROJECT-21K12239, KAKENHI-PROJECT-22KK0119, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-20H03714, KAKENHI-PROJECT-21H02948, KAKENHI-PROJECT-21J15620, KAKENHI-PROJECT-20H03717, KAKENHI-PROJECT-23K24368
[Journal Article] Exploring the mechanistic link between SF3B1 mutation and ring sideroblast formation in myelodysplastic syndrome2022
- Author(s)
  Ochi Tetsuro、Fujiwara Tohru、Ono Koya、Suzuki Chie、Nikaido Maika、Inoue Daichi、Kato Hiroki、Onodera Koichi、Ichikawa Satoshi、Fukuhara Noriko、Onishi Yasushi、Yokoyama Hisayuki、Nakamura Yukio、Harigae Hideo
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 14562-14562
- DOI
  10.1038/s41598-022-18921-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08385, KAKENHI-PROJECT-22K16294, KAKENHI-PROJECT-21K20770, KAKENHI-PROJECT-20H03717, KAKENHI-PROJECT-22K16295
[Journal Article] Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cell through activation of Akt/mTOR pathway.2021
- Author(s)
  Fujino, T., Goyama, S., Sugiura, Y., Inoue, D., Asada, S., Yamasaki, S., Matsumoto, A., Tsuchiya, A., Shikata, S., Sato N., Morinaga, H., Fukuyama, T., Tanaka, Y., Fukushima, T., Takeda, R., Yamamoto, K., Honda, H., Nishimura, E.K., Shibata, T., Abdel-Wahab, Omar., Suematsu, M., and Kitamura, T.
- Journal Title
  
  nature communications
  
  Volume: 12 Pages: 1826-1826
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00537
[Journal Article] Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition2021
- Author(s)
  Inoue D, Polaski JT, Taylor J, Castel P, Chen S, Kobayashi S, Hogg SJ, Hayashi Y, Fukumoto M, Yamazaki H, Tanaka A, Fukui C, Chew GL, McCormick F, Bradley RK, Abdel-Wahab O.
- Journal Title
  
  Nature Genetics
  
  Volume: 21 Issue: 5 Pages: 828-828
- DOI
  10.1038/s41588-021-00828-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00537, KAKENHI-PROJECT-21K08432, KAKENHI-PROJECT-22KJ3215
[Journal Article] Understanding and therapeutic targeting of aberrant mRNA splicing mechanisms in oncogenesis2020
- Author(s)
  田中淳、小林漸、肖慕然、井上大地
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 61 Issue: 6 Pages: 643-650
- DOI
  10.11406/rinketsu.61.643
- NAID
  130007869132
- ISSN
  0485-1439, 1882-0824
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00537
[Journal Article] HHEX promotes myeloid transformation in cooperation with mutant ASXL1.2020
- Author(s)
  Takeda R, Asada S, Park SJ, Yokoyama A, Becker H, Kanai A, Visconte V, Hershberger C, Hayashi Y, Yonezawa T, Tamura M, Fukushima T, Tanaka Y, Fukuyama T, Matsumoto A, Yamasaki S, Nakai K, Yamazaki S, Inaba T, Shibata T, Inoue D, Honda H, Goyama S, Maciejewski J, Kitamura T.
- Journal Title
  
  Blood
  
  Volume: 136 Pages: 1670-1684
- DOI
  10.1182/blood.2019004613
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22546, KAKENHI-PROJECT-19KK0216, KAKENHI-PLANNED-19H05746, KAKENHI-PROJECT-20H00537, KAKENHI-PROJECT-18H02838, KAKENHI-PROJECT-19H03693, KAKENHI-PROJECT-19J01570, KAKENHI-PROJECT-18K18196
[Journal Article] A novel ASXL1?OGT axis plays roles in H3K4 methylation and tumor suppression in myeloid malignancies2018
- Author(s)
  Inoue D, Fujino T, Sheridan P, Zhang YZ, Nagase R, Horikawa S, Li Z, Matsui H, Kanai A, Saika M, Yamaguchi R, Kozuka-Hata H, Kawabata KC, Yokoyama A, Goyama S, Inaba T, Imoto S, Miyano S, Xu M, Yang FC, Oyama M, Kitamura T.
- Journal Title
  
  Leukemia
  
  Volume: 印刷中 Issue: 6 Pages: 1327-1337
- DOI
  10.1038/s41375-018-0083-3
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05634, KAKENHI-PROJECT-15H04855, KAKENHI-PROJECT-15H04857, KAKENHI-PROJECT-16H05337, KAKENHI-PROJECT-18K18196, KAKENHI-PLANNED-16H06578, KAKENHI-PROJECT-18H02838
[Journal Article] Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation2018
- Author(s)
  Nagase R, Inoue D, Pastore A, Fujino T, Hou HA, Yamasaki N, Goyama S, Saika M, Kanai A, Sera Y, Horikawa S, Ota Y, Asada S, Hayashi Y, Kawabata KC, Takeda R, Tien HF, Honda H, Abdel-Wahab O, Kitamura T.
- Journal Title
  
  The Journal of Experimental Medicine
  
  Volume: 印刷中 Issue: 6 Pages: 1729-1747
- DOI
  10.1084/jem.20171151
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05634, KAKENHI-PROJECT-15H04855, KAKENHI-PROJECT-18K18196, KAKENHI-ORGANIZER-26115001, KAKENHI-PROJECT-17J05696, KAKENHI-INTERNATIONAL-15K21751
[Journal Article] High expression of ABCG2 induced by EZH2 disruption has pivotal roles in MDS pathogenesis2017
- Author(s)
  Kawabata K C、Hayashi Y、Inoue D、Meguro H、Sakurai H、Fukuyama T、Tanaka Y、Asada S、Fukushima T、Nagase R、Takeda R、Harada Y、Kitaura J、Goyama S、Harada H、Aburatani H、Kitamura T
- Journal Title
  
  Leukemia
  
  Volume: 32 Issue: 2 Pages: 419-428
- DOI
  10.1038/leu.2017.227
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09831, KAKENHI-PUBLICLY-17H05634, KAKENHI-PROJECT-15H03137, KAKENHI-PROJECT-15H04855, KAKENHI-PROJECT-15K09460, KAKENHI-PUBLICLY-17H05515, KAKENHI-PROJECT-17H04217
[Journal Article] Truncation mutants of ASXL1 observed in myeloid malignancies are expressed at detectable protein levels.2016
- Author(s)
  Inoue D, Matsumoto M, Nagase R, Saika M, Fujino T, Nakayama KI, Kitamura T.
- Journal Title
  
  Exp Hematol.
  
  Volume: 44 Issue: 3 Pages: 172-176
- DOI
  10.1016/j.exphem.2015.11.011
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-15H01407, KAKENHI-PROJECT-15H04855, KAKENHI-PROJECT-26893051, KAKENHI-PROJECT-26670465, KAKENHI-PROJECT-25290078, KAKENHI-PUBLICLY-26116721
[Journal Article] SETBP1 mutations drive leukemic transformation in ASXL1-mutated MDS.2015
- Author(s)
  Inoue D, Kitaura J, Matsui H, Hou HA, Chou WC, Nagamachi A, Kawabata KC, Togami K, Nagase R, Horikawa S, Saika M, Micol JB, Hayashi Y, Harada Y, Harada H, Inaba T, Tien HF, Abdel-Wahab O, Kitamura T.
- Journal Title
  
  Leukemia
  
  Volume: 29(4) Issue: 4 Pages: 847-57
- DOI
  10.1038/leu.2014.301
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-13J09414, KAKENHI-ORGANIZER-22118001, KAKENHI-PLANNED-22118002, KAKENHI-PROJECT-24249039, KAKENHI-PROJECT-24591398, KAKENHI-PUBLICLY-25118716, KAKENHI-PROJECT-26293231, KAKENHI-PROJECT-15K09460, KAKENHI-PROJECT-15H04855, KAKENHI-PROJECT-26893051, KAKENHI-PROJECT-25461422, KAKENHI-PROJECT-26670465, KAKENHI-PROJECT-26860735
[Journal Article] The stability of epigenetic factor ASXL1 is regulated through ubiquitination and USP7-mediated deubiquitination.2015
- Author(s)
  Inoue, D., Nishimura, K., Kozuka-Hata, H., Oyama, M. and Kitamura, T.
- Journal Title
  
  Leukemia
  
  Volume: in press Issue: 11 Pages: 2257-2260
- DOI
  10.1038/leu.2015.90
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-ORGANIZER-22118001, KAKENHI-PLANNED-22118002, KAKENHI-PROJECT-26505001, KAKENHI-PROJECT-15H04855, KAKENHI-PROJECT-26670465
[Patent] 変異型ASXL1のノックインマウス2017
- Inventor(s)
  北村俊雄、井上大地、永瀬玲奈
- Industrial Property Rights Holder
  国立大学法人　東京大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-063168
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-15H04855
[Presentation] Dual roles of BRD9 in normal and malignant hematopoiesis.2023
- Author(s)
  Inoue Daichi
- Organizer
  ASH/JSH 2023 Normal/Malignant Hematopoiesis and Novel Therapies for Hematologic Malignancies Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03717
[Presentation] スプライシング異常と血液悪性腫瘍2023
- Author(s)
  井上大地
- Organizer
  第85回日本血液学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K19475
[Presentation] 骨髄異形成症候群における骨髄間質細胞の病態解明2023
- Author(s)
  井上大地
- Organizer
  第22回日本再生医療学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03717
[Presentation] Altered Post-transcriptional regulation in malignant hematopoiesis2023
- Author(s)
  Daichi Inoue
- Organizer
  IRCMS Mini Symposium on Normal Hematopoiesis and Transformation
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03717
[Presentation] Deciphering the Mechanisms of Cancer Development Driven by Aberrant Splicing Events2023
- Author(s)
  Daichi Inoue
- Organizer
  SECOND JCA-AACR PRECISION CANCER MEDICINE INTERNATIONAL CONFERENCE
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03717
[Presentation] 血液がんの発症・維持機構の探索ースプライシングと微小環境の観点から2023
- Author(s)
  井上大地
- Organizer
  神戸大学CMX創発医学講演会
- Invited
- Data Source
  KAKENHI-PROJECT-20K21622
[Presentation] Deciphering the Mechanisms of Cancer Development Driven by Aberrant Splicing Events2023
- Author(s)
  Daichi Inoue
- Organizer
  SECOND JCA-AACR PRECISION CANCER MEDICINE INTERNATIONAL CONFERENCE
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19475
[Presentation] Dual roles of BRD9 in normal and malignant hematopoiesis2023
- Author(s)
  Daichi Inoue
- Organizer
  ASH/JSH 2023 Normal/Malignant Hematopoiesis and Novel Therapies for Hematologic Malignancies Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03717
[Presentation] 骨髄異形成症候群における骨髄間質細胞の病態解明2023
- Author(s)
  井上大地
- Organizer
  第22回日本再生医療学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-20K21622
[Presentation] Unraveling the Mechanisms of Aberrant Post-Transcriptional Regulation in Cancer: Implications for Therapeutic Strategies2023
- Author(s)
  Daichi Inoue
- Organizer
  第82回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-22K19475
[Presentation] Unraveling the Mechanisms of Aberrant Post-Transcriptional Regulation in Cancer: Implications for Therapeutic Strategies2023
- Author(s)
  Daichi Inoue
- Organizer
  第82回日本癌学会学術総会The JCA-Mauvernay Awards Session
- Invited
- Data Source
  KAKENHI-PROJECT-23H00430
[Presentation] BRD9を標的とした血液がん治療2023
- Author(s)
  井上大地
- Organizer
  第27回日本がん分子標的治療学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03717
[Presentation] MDS細胞由来のエキソソームを介した間葉系幹細胞の改変とMDS進展2022
- Author(s)
  井上大地
- Organizer
  CLL Expert Seminar
- Invited
- Data Source
  KAKENHI-PROJECT-20K21622
[Presentation] がんたらしめるものは何か？ースプライシングと微小環境の観点から2022
- Author(s)
  井上大地
- Organizer
  佐賀ブルートアーベント
- Invited
- Data Source
  KAKENHI-PROJECT-20K21622
[Presentation] Dissecting the mechanisms for cancer development caused by aberrant splicing.2022
- Author(s)
  Inoue Daichi
- Organizer
  The 12th AACR-JCA Joint Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03717
[Presentation] ブロモドメインタンパクの転写後制御を介した造血幹細胞運命制御機構2022
- Author(s)
  井上大地
- Organizer
  第45回日本分子生物学会年会（幕張）
- Invited
- Data Source
  KAKENHI-PROJECT-20H03717
[Presentation] ブロモドメインタンパクのスプライシング異常がもたらす細胞運命制御2022
- Author(s)
  井上大地
- Organizer
  第95回日本生化学会大会（名古屋）
- Invited
- Data Source
  KAKENHI-PROJECT-20H03717
[Presentation] MDS由来のエキソソームを介した骨髄ニッチ改変機構2022
- Author(s)
  井上大地
- Organizer
  北関東血液疾患講演会
- Invited
- Data Source
  KAKENHI-PROJECT-20K21622
[Presentation] 造血幹細胞由来のエキソソームを介した間葉系幹細胞の改変とMDS進展2022
- Author(s)
  井上大地
- Organizer
  第18回感染症サイトカイン研究会
- Invited
- Data Source
  KAKENHI-PROJECT-20K21622
[Presentation] Aberrant splicing events lead to altered cell fate of hematopoietic stem cells.2022
- Author(s)
  Inoue Daichi
- Organizer
  The 19th Stem Cell Research Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03717
[Presentation] 造血細胞の運命制御機構の解明に向けてースプライシングと微小環境の観点から2022
- Author(s)
  井上大地
- Organizer
  第1回東北大学大学院講義研究推進・研究倫理ゼミ
- Invited
- Data Source
  KAKENHI-PROJECT-20K21622
[Presentation] Dysregulated Minor Intron Splicing and Cancer.2022
- Author(s)
  Inoue Daichi
- Organizer
  第81回日本癌学会学術総会（横浜）
- Invited
- Data Source
  KAKENHI-PROJECT-20H03717
[Presentation] The Blood-Bone Association in Normal and Malignant Hematopoiesis2021
- Author(s)
  井上大地
- Organizer
  第94回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-20K21622
[Presentation] RNAの視点からみた造血器腫瘍2020
- Author(s)
  井上大地
- Organizer
  第11回神奈川MDS研究会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03717
[Presentation] スプライシング異常から紐解く造血器腫瘍2020
- Author(s)
  井上大地
- Organizer
  第３回先端医科学研究センター「マルチオミックスによる遺伝子現制御の先端的医学共同研究拠点」セミナー
- Data Source
  KAKENHI-PROJECT-20H00537
[Presentation] マイナーイントロンを介した発癌機構2020
- Author(s)
  井上大地
- Organizer
  鶴岡カンファレンス2020
- Data Source
  KAKENHI-PROJECT-20H00537
[Presentation] Clarifying the Role of Minor Introns in Cancer Predisposition2020
- Author(s)
  井上大地
- Organizer
  The 4th CCII Seminar
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03717
[Presentation] 造血幹細胞を中心とした多細胞間の適応・修復ネットワークの解明と制御2020
- Author(s)
  井上大地
- Organizer
  AMED-CREST/PRIMEキックオフ・領域会議
- Data Source
  KAKENHI-PROJECT-20H00537
[Presentation] イントロンから発癌を読み解く2020
- Author(s)
  井上大地
- Organizer
  東京血液懇話会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03717
[Presentation] Clarifying the Role of Minor Introns in Cancer Predisposition2020
- Author(s)
  井上大地
- Organizer
  4th CCII Seminar
- Data Source
  KAKENHI-PROJECT-20H00537
[Presentation] マイナーイントロンを介した発癌機構2020
- Author(s)
  井上大地
- Organizer
  鶴岡カンファレンス2020
- Invited
- Data Source
  KAKENHI-PROJECT-20H03717
[Presentation] スプライシング異常から紐解く造血器腫瘍2020
- Author(s)
  井上大地
- Organizer
  第３回先端医科学研究センター「マルチオミックスによる遺伝発現制御の先端的医学共同研究拠点」セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-20H03717
[Presentation] スプライシング異常を介した新規発がん機構2020
- Author(s)
  井上大地
- Organizer
  第92回日本遺伝学会ワークショップ
- Invited
- Data Source
  KAKENHI-PROJECT-20H03717
[Presentation] ZRSR2 Mutation Induced Minor Intron Retention Drives MDS and Diverse Cancer Predisposition Via Aberrant Splicing of LZTR12020
- Author(s)
  井上大地
- Organizer
  The 62nd ASH Annual Meeting and Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03717
[Presentation] Mutant ASXL1 induces expansion of hematopoietic stem cells through activation of Akt/mTOR pathway2020
- Author(s)
  藤野赳至、合山進、Yuki Sugiura、井上大地、浅田修平、Satoshi Yamasaki、Akiko Matsumoto、Kiyoshi Yamaguchi、土屋秋穂、四方紫織、佐藤成、Hironobu Morinaga、福山朋房、田中洋介、福島剛、竹田玲奈、山本圭太、本田浩章、Emi K. Nishimura、古川洋一、Tatsuhiro Shibata、Omar Abdel-Wahab、末松誠、北村俊雄
- Organizer
  ISEH 2020 Virtual Scientific Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00537
[Presentation] ZRSR2 Mutation Induced Minor Intron Retention Drives MDS and Diverse Cancer Predisposition Via Aberrant Splicing of LZTR12020
- Author(s)
  井上大地
- Organizer
  The 62nd ASH Annual Meeting and Exposition
- Data Source
  KAKENHI-PROJECT-20H00537
[Presentation] RNAの視点からみた造血器腫瘍2020
- Author(s)
  井上大地
- Organizer
  第11回神奈川MDS研究会
- Data Source
  KAKENHI-PROJECT-20H00537
[Presentation] スプライシング異常を介した新規発がん機構2020
- Author(s)
  井上大地
- Organizer
  第92回日本遺伝学会ワークショップ
- Data Source
  KAKENHI-PROJECT-20H00537
[Presentation] イントロンから発癌を読み解く2020
- Author(s)
  井上大地
- Organizer
  東京血液懇話会
- Data Source
  KAKENHI-PROJECT-20H00537
[Presentation] Mutant ASXL1 Cooperates with BAP1 to Promote Myeloid Leukemogenesis2017
- Author(s)
  浅田修平、合山進、井上大地、竹田玲奈、河津正人、間野博行、北村俊雄
- Organizer
  The 59th American Society of Hematology annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04855
[Presentation] Novel roles of ASXL1 in epigenetic regulation2015
- Author(s)
  Daichi Inoue, Sayuri Horikawa, Hirotaka Matsui. Reina Nagase, Makoto Saika, Kimihito Kawabata, Susumu Goyama, Toshio Kitamura
- Organizer
  ISEH 44th Annual Scientific Meeting
- Place of Presentation
  国立京都国際会館（京都府・京都市）
- Year and Date
  2015-09-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26893051
[Presentation] Novel roles of ASXL1 in epigenetic regulation2015
- Author(s)
  井上大地
- Organizer
  THE ISEH 44th Annual Scientific Meeting
- Place of Presentation
  国立京都国際会館・京都府京都市
- Year and Date
  2015-09-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04855
[Presentation] SETBP1 Mutations Drive Leukemic Transformation in ASXL1-Mutated MDS2014
- Author(s)
  Inoue D, Kitamura T
- Organizer
  第76回日本血液学会総会
- Place of Presentation
  大阪　国際会議場
- Year and Date
  2014-10-31
- Data Source
  KAKENHI-PROJECT-26893051
[Presentation] SETBP1 Mutations Drive Leukemic Transformation in ASXL1-Mutated MDS2014
- Author(s)
  Inoue D, Kitamura T
- Organizer
  The 56th American Society of Hematology annual meeting
- Place of Presentation
  米国　サンフランシスコ
- Year and Date
  2014-12-08
- Data Source
  KAKENHI-PROJECT-26893051

1. Kitamura Toshio (20282527)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
2. Fukuyama Tomofusa (10300906)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 北浦次郎 (30282651)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 諸石寿朗 (30647722)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 小嶋良輔 (10808059)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 谷内江望 (60636801)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 網代将彦 (60761864)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 平木嘉樹 (90882895)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 本村有史 (00826365)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 平川雅和 (20380454)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 三森功士 (50322748)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. HARADA Yuka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. YOSHIDA Hitoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 山嵜博未

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 松本雅記

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 原田浩徳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 國本博義

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 本田善一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 本田浩章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 藤原亨

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

INOUE DAICHI 井上 大地

Inoue Daichi 井上 大地

井上 大地 イノウエ ダイチ

Research Projects

Research Products

Co-Researchers

「適応多様性」研究領域の拡大・発展に向けた総括研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

生体イベントにおける造血幹細胞の「適応多様性」の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

新次元の単一細胞解析が駆動する骨髄造血系の統合的理解Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

転写後制御機構の観点からみる造血異常と治療応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Cancer immune therapeutics targeting aberrant RNA splicing products

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

転写産物のロングリード・シーケンスによる食道癌化学放射線療法抵抗性獲得機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Clarifying Regulatory System of Minor Introns through Evolution and Cancer DevelopmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of hematopoietic dysfunction via extracellular vesicles and its therapeutic applicationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Studies of MDS pathogenesis and its relation to novel therapeutic strategies

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of MDS pathogenesis based on understanding the roles of newly identified SWI/SNF complexPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Comprehensive elucidation of MDS (myelodysplastic syndromes) pathogenesis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of SETBP1 mutation in leukemic transformationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Minor introns impact on hematopoietic malignancies2024

Author(s)

INOUE DAICHI 井上大地

Inoue Daichi 井上大地

井上大地イノウエダイチ