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Koyama Syohei  小山 正平

… Alternative Names

Koyama Shohei  小山 正平

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Researcher Number 80767559
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-6897-9417
Affiliation (Current) 2025: 国立研究開発法人国立がん研究センター, 研究所, 部門長
2025: 国立研究開発法人国立がん研究センター, 先端医療開発センター, 研究員
2025: 大阪大学, 大学院医学系研究科, 特任准教授
Affiliation (based on the past Project Information) *help 2021 – 2024: 大阪大学, 大学院医学系研究科, 特任准教授
2020 – 2023: 国立研究開発法人国立がん研究センター, 先端医療開発センター, ユニット長
2019 – 2021: 大阪大学, 医学系研究科, 特任助教
2018 – 2019: 大阪大学, 医学系研究科, 助教
2017: 大阪大学, 大学院医学系研究科, 助教(常勤)
2016 – 2017: 大阪大学, 免疫学フロンティア研究センター, 特任助教(常勤)
2015: 大阪大学, 学内共同利用施設等, 助教
Review Section/Research Field
Principal Investigator
Basic Section 50010:Tumor biology-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Respiratory organ internal medicine
Except Principal Investigator
Basic Section 59040:Nutrition science and health science-related / Basic Section 90110:Biomedical engineering-related / Medium-sized Section 47:Pharmaceutical sciences and related fields / Medical pharmacy / Respiratory organ internal medicine
Keywords
Principal Investigator
腫瘍浸潤T細胞 / 免疫抑制 / 肺がん合併 / 肺線維症 / TCRレパトア / 長期治療効果 / 免疫チェックポイント阻害 / 末梢血T細胞 / 神経ガイダンス因子 / CD8陽性T細胞 … More / 免疫チェックポイント阻害薬 / 免疫療法耐性化 / 活性化好中球 / 非小細胞肺癌 / 肺がん / 抗PD-1抗体 / 好中球 / がん免疫 … More
Except Principal Investigator
骨髄由来免疫抑制細胞 / 脂肪酸 / がん免疫 / パルミチン酸 / MDSC / 免疫抑制 / 代謝 / CAR-T細胞免疫療法 / T細胞免疫療法 / 乳がん / 腫瘍内免疫微小環境 / がん免疫療法 / イムノモジュレーション / 腫瘍微小環境 / 養子免疫療法 / マイクロバブル / 超音波 / 免疫 / がん / エピジェネティクス / 転写因子 / 線維芽細胞 / 血管内皮細胞 / ダイレクトリプログラミング / 線維化疾患 / アレルギー / ペプチド / 薬学 / 創薬 / 感染症 / 免疫改変 / ワクチン / 送達担体 / 機能性ペプチド / 内在性リガント / MyD88 / 腫瘍関連線維芽細胞 / 腫瘍関連マクロファージ / 無菌的炎症 / 微小環境 / Toll様受容体 / 化学療法抵抗性 / 無菌的炎症誘導 / アポトーシス小体 / 内在性リガンド / 癌微小環境 / 肺癌 Less
  • Research Projects

    (9 results)
  • Research Products

    (24 results)
  • Co-Researchers

    (20 People)
  •  Fundamental analysis of lung cancer development associated with fibrosisPrincipal Investigator

    • Principal Investigator
      小山 正平
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Osaka University
  •  Regulation of myeloid-derived suppressor cells by palmitic acid metabolism for next-generation cancer immunotherapy

    • Principal Investigator
      立花 雅史
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      Ritsumeikan University
      Osaka University
  •  Basic evaluation and investigation of the factors linked to the long term response to immunotherapiesPrincipal Investigator

    • Principal Investigator
      Koyama Shohei
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      National Cancer Center Japan
  •  Development of novel treatment for fibrotic diseases using direct reprogramming technology

    • Principal Investigator
      Okada Yoshiaki
    • Project Period (FY)
      2020 – 2021
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 47:Pharmaceutical sciences and related fields
    • Research Institution
      Osaka University
  •  Development of novel cancer therapy based on promotion of tumor infiltrating lymphocyte by the immunomodulation with ultrasound technology

    • Principal Investigator
      Suzuki Ryo
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 90110:Biomedical engineering-related
    • Research Institution
      Teikyo University
  •  Elucidation of the regulatory mechanisms myeloid-derived suppressor cells by lipid metabolism and its application to cancer therapy

    • Principal Investigator
      Tachibana Masashi
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      Osaka University
  •  Regulating the sensitivity of lung cancer to immunotherapy through inhibiting neutrophil activation and promoting T cell infiltration in tumorsPrincipal Investigator

    • Principal Investigator
      Koyama Shohei
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Osaka University
  •  Development of peptides that target immune cells and their application for therapy of immune-related diseases

    • Principal Investigator
      Yoshioka Yasuo
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Medical pharmacy
    • Research Institution
      Osaka University
  •  Developing novel lung cancer therapy targetting cancer cell intrinsic ligands

    • Principal Investigator
      Kijima Takashi
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Osaka University

All 2024 2023 2022 2019 2018 2017

All Journal Article Presentation

  • [Journal Article] Sema6D forward signaling impairs T cell activation and proliferation in head and neck cancer2024

    • Author(s)
      Hirai Takashi、Naito Yujiro、Koyama Shohei、Aoshi Taiki、Villa Jordan Kelly、Yamashita Kazuo、Enokida Tomohiro、Hoshi Yuta、Matsuura Kazuto、Tahara Makoto、Takamatsu Hyota、Takeda Yoshito、Inohara Hidenori、Kumanogoh Atsushi
    • Journal Title

      JCI Insight

      Volume: 9 Issue: 3 Pages: 1-2

    • DOI

      10.1172/jci.insight.166349

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K08283, KAKENHI-PROJECT-21K07252, KAKENHI-PROJECT-22K16361
  • [Journal Article] Precise patient stratification in esophageal cancer: Biomarkers for immunochemotherapy2023

    • Author(s)
      Kumagai Shogo、Koyama Shohei、Shitara Kohei
    • Journal Title

      Cancer Cell

      Volume: 41 Issue: 7 Pages: 1199-1201

    • DOI

      10.1016/j.ccell.2023.06.004

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K07252
  • [Journal Article] Tumor-derived semaphorin 4A improves PD-1 blocking antibody efficacy by enhancing CD8+ T-cell cytotoxicity and proliferation2023

    • Author(s)
      Naito Y et al
    • Journal Title

      Science Advances

      Volume: - Issue: 20 Pages: 1-2

    • DOI

      10.1126/sciadv.ade0718

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07252, KAKENHI-PROJECT-22K08283, KAKENHI-PROJECT-23K06696, KAKENHI-PROJECT-22K16361, KAKENHI-PROJECT-23K27671
  • [Journal Article] Bronchoalveolar lavage fluid reveals factors contributing to the efficacy of PD-1 blockade in lung cancer2022

    • Author(s)
      Masuhiro Kentaro、Tamiya Motohiro、Fujimoto Kosuke
    • Journal Title

      JCI Insight

      Volume: 1 Issue: 9 Pages: 1-1

    • DOI

      10.1172/jci.insight.157915

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08650, KAKENHI-PROJECT-21K07252, KAKENHI-PROJECT-21K07112, KAKENHI-PROJECT-22K08283, KAKENHI-PROJECT-18H05282, KAKENHI-PROJECT-22H00477, KAKENHI-PROJECT-21H03538, KAKENHI-PROJECT-21K19495
  • [Journal Article] Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments2022

    • Author(s)
      Kumagai S, Koyama S, Itahashi K, Tanegashima T, Lin YT, Togashi Y, Kamada T, Irie T, Okumura G, Kono H, Ito D, Fujii R, Watanabe S, Sai A, Aokage K, Suzuki J, Ishii G, Kuwata T, Sakamoto N, Kawazu M, Ueno T, Mori T, Yamazaki N, Tsuboi M, Yatabe Y, Kinoshita T, Doi T, Shitara K, Mano H, Nishikawa H
    • Journal Title

      Cancer Cell

      Volume: 40 Issue: 2 Pages: 201-218

    • DOI

      10.1016/j.ccell.2022.01.001

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H06162, KAKENHI-PROJECT-20H03461, KAKENHI-PROJECT-20H03694, KAKENHI-PROJECT-20H04519, KAKENHI-PROJECT-21H02772, KAKENHI-PROJECT-20K07383, KAKENHI-PROJECT-20K08531, KAKENHI-PROJECT-21K07112, KAKENHI-PROJECT-21K07252, KAKENHI-PROJECT-21K12117, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-22KJ3156, KAKENHI-PROJECT-22H00455
  • [Journal Article] Suppression of Myeloid Cell Arginase Activity leads to Therapeutic Response in a NSCLC Mouse Model by Activating Anti-Tumor Immunity2019

    • Author(s)
      Miret Juan J.、Kirschmeier Paul、Koyama Shohei、Zhu Mingrui、Li Yvonne Y.、Naito Yujiro、Wu Min、Malladi Venkat S.、Huang Wei、Walker William、Palakurthi Sangeetha、Dranoff Glenn、Hammerman Peter S.、Pecot Chad V.、Wong Kwok-Kin、Akbay Esra A.
    • Journal Title

      Journal for ImmunoTherapy of Cancer

      Volume: 7 Issue: 1 Pages: 32-32

    • DOI

      10.1186/s40425-019-0504-5

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K16045
  • [Journal Article] Semaphorin 7A promotes EGFR-TKI resistance in EGFR mutant lung adenocarcinoma cells2018

    • Author(s)
      Kinehara Y, Nagatomo I, Koyama S,(30名飛ばして), Kida H, Kumanogoh A
    • Journal Title

      JCI Insight

      Volume: 3 Issue: 24

    • DOI

      10.1172/jci.insight.123093

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09537, KAKENHI-PROJECT-17K16045, KAKENHI-PROJECT-18H05282
  • [Journal Article] Selecting suitable chemotherapies for PD-1/PD-L1 blockade to optimize the tumor immune microenvironment2018

    • Author(s)
      Koyama Shohei、Nagatomo Izumi、Kijima Takashi、Kumanogoh Atsushi
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 66 Pages: 32552-32553

    • DOI

      10.18632/oncotarget.26028

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K16045, KAKENHI-PROJECT-18H05282
  • [Journal Article] Clinical implications of monitoring nivolumab immunokinetics in non?small cell lung cancer patients2018

    • Author(s)
      Osa A, Uenami T, Koyama S, (22名飛ばして), Kida H, Akbay EA, Hammerman PS, Wong KK, Dranoff G, Mori M, Kijima T, Kumanogoh A
    • Journal Title

      JCI Insight

      Volume: 3 Issue: 19

    • DOI

      10.1172/jci.insight.59125

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09537, KAKENHI-PROJECT-17K16045, KAKENHI-PROJECT-18H05282
  • [Journal Article] Interleukin-17A Promotes Lung Tumor Progression through Neutrophil Attraction to Tumor Sites and Mediating Resistance to PD-1 Blockade2017

    • Author(s)
      Akbay Esra A.、Koyama Shohei、Liu Yan、Dries Ruben、Bufe Lauren E.、Silkes Michael、Alam MD Maksudul、Magee Dillon M.、Jones Robert、Jinushi Masahisa、Osa Akio、Kumanogoh Atsushi、Freeman Gordon J.、Awad Mark M.、Christiani David C.、Bueno Raphael、Hammerman Peter S.、Dranoff Glenn、Wong Kwok-Kin
    • Journal Title

      Journal of Thoracic Oncology

      Volume: 12 Issue: 8 Pages: 1268-1279

    • DOI

      10.1016/j.jtho.2017.04.017

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K16045
  • [Presentation] 婦人科がんの腫瘍免疫微小環境と免疫療法.2024

    • Author(s)
      小山正平
    • Organizer
      第21回日本臨床腫瘍学会学術集会.
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K07252
  • [Presentation] 免疫細胞浸潤性の低い腫瘍(Cold tumor)に対する効果的ながん免疫療法の開発2023

    • Author(s)
      加藤吏恵、宗像理紗、青枝大貴、小山正平、小俣大樹、鈴木悠乃、岡田欣晃、吉岡靖雄、鈴木 亮
    • Organizer
      日本薬学会第143年会
    • Data Source
      KAKENHI-PROJECT-20H04519
  • [Presentation] 腫瘍微小環境における制御性T細胞の役割.2023

    • Author(s)
      小山正平
    • Organizer
      第82回日本癌学会学術総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K07252
  • [Presentation] Toward Development of Next-generation Cancer Immunotherapies.2023

    • Author(s)
      Koyama S
    • Organizer
      第27回がん研-国際がん化学療法シンポジウム(第27回JFCR-ISCC)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07252
  • [Presentation] 免疫抑制的な腫瘍内微小環境を有する腫瘍への効果的ながん免疫療法構築に向けた基礎的研究2022

    • Author(s)
      宗像理紗、青枝大貴、小山正平、小俣大樹、丸山 保、鈴木悠乃、萩原芙美子、岡田欣晃、吉岡靖雄、鈴木 亮
    • Organizer
      日本薬学会第142年会
    • Data Source
      KAKENHI-PROJECT-20H04519
  • [Presentation] 固形がんに対する養子免疫療法とマイクロバブル-超音波併用による抗腫瘍効果の増強に関する検討2022

    • Author(s)
      丸山 保、宗像理紗、小俣大樹、鈴木悠乃、小山正平、岡田欣晃、鈴木 亮
    • Organizer
      日本薬剤学会第37年会
    • Data Source
      KAKENHI-PROJECT-20H04519
  • [Presentation] マイクロバブルと超音波照射による固形がん組織の腫瘍微小環境変化を介した養子免疫療法の抗腫瘍効果増強に関する検討2022

    • Author(s)
      鈴木 亮、丸山 保、宗像理紗、鈴木悠乃、小俣大樹、工藤信樹、小山正平、岡田欣晃
    • Organizer
      日本ハイパーサーミア学会39回大会
    • Data Source
      KAKENHI-PROJECT-20H04519
  • [Presentation] Development of type A CpG oligodeoxynucleotide loaded lipid nanoparticles as an adjuvant for cancer immunotherapy2022

    • Author(s)
      宗像理紗、青枝大貴、小山正平、小俣大樹、鈴木悠乃、岡田欣晃、吉岡靖雄、鈴木 亮
    • Organizer
      第16回次世代を担う若手のための医療薬科学シンポジウム
    • Data Source
      KAKENHI-PROJECT-20H04519
  • [Presentation] マイクロバブルと超音波併用による免疫微小環境の変化と養子免疫療法の抗腫瘍効果増強に関する基礎的検討2022

    • Author(s)
      丸山 保、宗像理紗、小俣大樹、萩原芙美子、鈴木悠乃、小山正平、岡田欣晃、工藤信樹、鈴木 亮
    • Organizer
      日本薬学会第142年会
    • Data Source
      KAKENHI-PROJECT-20H04519
  • [Presentation] 免疫抑制的な環境を構築する腫瘍への抗腫瘍免疫誘導に関する検討2022

    • Author(s)
      宗像理紗、小俣大樹、小山正平、岡田欣晃、吉岡靖雄、青枝大貴、鈴木 亮
    • Organizer
      日本核酸医薬学会第7年会
    • Data Source
      KAKENHI-PROJECT-20H04519
  • [Presentation] 臨床におけるがん免疫治療のdata gapとTranslational Research2019

    • Author(s)
      小山 正平
    • Organizer
      第 23 回日本がん免疫学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K16045
  • [Presentation] Analysis of whole blood cell as a predictive marker in nivolumab-treated non-small cell lung cancer patients2018

    • Author(s)
      Akio Osa , Yujiro Naito , Shohei Koyama , Takeshi Uenami , Masahide Mori , Atsushi Kumanogoh
    • Organizer
      SITC(Society for Immunotherapy of Cancer) 2018 Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K16045
  • [Presentation] Monitoring Nivolumab Binding as a Method to Clarify the Residual Therapeutic Effects in Previously Treated Lung Cancer Patients.2017

    • Author(s)
      A. Osa, S. Koyama, T. Uenami, K. Fujimoto, Y. Naito, H. Hirata, T. Takimoto, I. Nagatomo, Y. Takeda, H. Kida, M. Mori, T. Kijima, A. Kumanogoh
    • Organizer
      World Conference on Lung Cancer, Oct 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09220
  • [Presentation] Monitoring Nivolumab Binding as a Method to Clarify the Residual Therapeutic Effects in Previously Treated Lung Cancer Patients2017

    • Author(s)
      A. Osa, S. Koyama, T. Uenami, K. Fujimoto, Y. Naito, H. Hirata, T. Takimoto, I. Nagatomo, Y. Takeda, H. Kida, M. Mori, T. Kijima, A. Kumanogoh
    • Organizer
      World Conference on Lung Cancer 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K16045
  • 1.  Okada Yoshiaki (50444500)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
  • 2.  Tachibana Masashi (80513449)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  Kijima Takashi (90372614)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 4.  Yoshioka Yasuo (00392308)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  Suzuki Ryo (90384784)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
  • 6.  南 俊行 (00705113)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  長 彰翁 (20751390)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 8.  森村 治 (80743765)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  内藤 祐二朗 (30800982)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 10.  黒田 悦史 (10299604)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  青枝 大貴 (10324344)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  樋野 展正 (90469916)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  原田 和生 (50397741)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  工藤 信樹 (30271638)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 15.  渡邊 翔 (20529804)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  TAKEDA YOSHITO
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 17.  KIDA Hiroshi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 18.  Doi Toshihiko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 19.  西川 博嘉
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 20.  河野 隆志
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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