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Mano Hiroyuki  間野 博行

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MANO Hiroyuki  間野 博行

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Researcher Number 90240704
Other IDs
Affiliation (Current) 2025: 国立研究開発法人国立がん研究センター, 研究所, 研究所長
2025: 東京大学, 大学院医学系研究科(医学部), 委嘱教授
Affiliation (based on the past Project Information) *help 2014: 東京大学, 大学院医学系研究科, 教授
2012: 自治医科大学, 医学部, 教授
2001 – 2009: 自治医科大学, 医学部, 教授
2003 – 2005: 自治医科大学, ゲノム機能研究部, 教授
1995 – 2000: Jichi Med.Sch., Depart.of Medicine, Associate Professor, 医学部, 助教授 … More
1994 – 1995: Jichi Medical School, Dept.Molecular Biology, Assistant professor, 医学部, 講師
1992 – 1993: Faculty of Medicine, University of Tokyo, Assistant Prof., 医学部(病), 助手
1992: 東京大学, 医学部・(病), 助手 Less
Review Section/Research Field
Principal Investigator
Biological Sciences / Gastroenterology / Hematology
Except Principal Investigator
Hematology / Hematology / Biological Sciences / General medical chemistry
Keywords
Principal Investigator
サイトカイン / チロシンキナーゼ / DNAチップ / Tec / 白血病 / レトロウィルス / Dahlラット / AC133 / 遺伝子治療 / gene expression profiling … More / DNA microarray / acute mveloid leukemia / 網羅的遺伝子発現解析 / 網羅的清伝子発現解析 / マイクロRNA / 急性骨髄性白血病 / リシークエンス / CD133 / DNAマイクロアレイ / DNA chip / Pancreatic carcinoma / 膵臓がん / retrovirus / leukemia / oncogene / レトロウイルス / がん遺伝子 / レトロイィルス / alpha fetoprotein / hepatocellular carcinoma / アルファフェトプロティン / 自殺遺伝子 / アルファフェトプロテイン / 肝細胞癌 / Anti-sense / Protein-tyrosine kinase / アンチセンス / 心不全 / 心肥大 / Rho / 三量体G蛋白質 / 肝細胞がん … More
Except Principal Investigator
遺伝子治療 / 血管新生 / CD133 / ITR / Rep / AAV / PCR / CD34 / C3H10T1 / AML1 / ALL / Fyn / SH3 / v-Crk / Src / トランスジェニックマウス / アポトーシス / 自殺遺伝子 / レトロウイルスベクター / 遺伝子導入 / 造血幹細胞 / レセプター型チロシンキナーゼ / リン酸化 / myeloperoxidase / dysplasia / classification / gene expression profile / leukemia / 形態的異形性 / ミエロペルオキシダーゼ / 形態的異形成 / 分類 / 遺伝子発現プロファイル / 白血病 / selective amplifier gene / chronic granulomatous disease / hematopoietic stem cells / gene therapy / 選択的増幅遺伝子 / 慢性肉芽腫症 / TVI method / AVVS1 locus / integration / Gene transfer / Gene therapy / AAVS1 / TVI法 / AAVS1領域 / 遺伝子組込み / tyrosine phosphatase / チロシレフォスファターゼ / チロシンフォスファターゼ / チロシンファスファターゼ / Hematopoiesis-supporting ability / Differentiation induction / 2 cell / Preadipocyte / Stromal cell / 造血支持能 / 分化誘導 / 2細胞 / 前脂肪細胞 / ストローマ細胞 / p16 gene / suppressor oncogene / transcription factor / chimeric protein / EVI-1 / chromosomal translocation / 複合転座 / RT-PCR法 / t(15;17)転座 / RARのキメラ遺伝子 / PML / 急性前骨髄球性白血病 / 転写因子 / EVI-1キメラ遺伝子 / t(3;21)転座 / 急性転化 / 慢性骨髄性白血病 / 転座型白血病 / 癌抑制遺伝子 / EVi-1 / p16遺伝子 / 癌抑制遺 / 転写制御因子 / キメラ蛋白質 / Evi-1 / AML-1 / 染色体転座 / Alternative splicing / Receptor-type protein tyrosine kinase / Phosphorylation / ltk protein / alternative splicing / レセプタ-型チロシンキナ-ゼ / 細胞外領域 / 造血細胞 / 翻訳開始点 / シグナル伝達物質 / ltk遺伝子 / GPIアンカー膜蛋白 / AC133^+細胞 / SCIDマウス / 免疫療法 / DNAマイクロアレイ / PNH / 血液免疫学 / ゲノム医学 / リンパ管新生 / 転移 / がん浸潤 / がん微小環境 / ゲノム科学 / 生体イメージング / 生体材料 / シグナル伝達 / 微小環境 / LTK / SHZ / チロシンキナーゼ / p-130^<cas> / G-CSF / サイトカイン / エストロゲン受容体 / Fas / SH2 / インテグリン / Fak / P130^<cas> / abl> / p210^<bcr / Ph^1染色体 / ストロース細胞 / リン酸化蛋白 / ltk蛋白質 / 細胞内シグナル伝達機構 / ヒトltk遺伝子 / チミジン ホスホリラーゼ / 増殖因子 / ヌクレオチド / 血小板 / thymidine phosphorylase / 燐酸化 / (血小板由来血管内皮細胞増殖因子) / PD-ECGF Less
  • Research Projects

    (39 results)
  • Research Products

    (38 results)
  • Co-Researchers

    (39 People)
  •  Integrative Research on Cancer Microenvironment Network

    • Principal Investigator
      MIYAZONO Kohei
    • Project Period (FY)
      2010 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Basic study of immunotherapy with peptide vaccine in PNH

    • Principal Investigator
      NOJI Hideyoshi
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Fukushima Medical University
  •  Molecular targeted therapy of hematological malignancies based on the genomic informationPrincipal Investigator

    • Principal Investigator
      MANO Hiroyuki
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Jichi Medical University
  •  Development of a new classification for AML based on the gene expression profile in leukemia stem cells.

    • Principal Investigator
      TOMONAGA Masao
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Nagasaki University
  •  本態性高血圧症および心不全発症機構に関する包括的ゲノム解析Principal Investigator

    • Principal Investigator
      間野 博行
    • Project Period (FY)
      2001 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Jichi Medical University
  •  Screening of genes specifically activated in the pancreatic juice ductal cells from the patients with pancreatic ductal carcinomaPrincipal Investigator

    • Principal Investigator
      MANO Hiroyuki
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Jichi Medical School
  •  ゲノミクス技術を用いた造血幹細胞の腫瘍化機構解析Principal Investigator

    • Principal Investigator
      間野 博行
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      Jichi Medical University
  •  本態性高血圧症および心不全発症機構に関する包括的ゲノム解析Principal Investigator

    • Principal Investigator
      間野 博行
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Jichi Medical University
  •  ゲノミクス技術を用いた新しいスクリーニング法による白血病関連遺伝子の同定Principal Investigator

    • Principal Investigator
      間野 博行
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Jichi Medical University
  •  Tecキナーゼのシングル伝達Principal Investigator

    • Principal Investigator
      間野 博行
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Jichi Medical University
  •  Gene transfer into hematopoietic stem cells and gene therapy for chronic granulomatous disease

    • Principal Investigator
      KUME Akihiro
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Jichi Medical School
  •  Tecチロシンキナーゼと相互作用する細胞内シグナル伝達分子群の同定Principal Investigator

    • Principal Investigator
      間野 博行
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Jichi Medical University
  •  Tecチロシンキナーゼを介する造血細胞のシグナル伝達Principal Investigator

    • Principal Investigator
      間野 博行
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      Jichi Medical University
  •  Isolation of hematopoietic-specific oncogenes by a novel expression screening methodPrincipal Investigator

    • Principal Investigator
      MANO Hiroyuki
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Jichi Medical School
  •  Tec チロシンキナーゼと造血調節因子Principal Investigator

    • Principal Investigator
      間野 博行
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Jichi Medical University
  •  Tecチロシンキナーゼを介する細胞増殖機構の解析Principal Investigator

    • Principal Investigator
      間野 博行
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Jichi Medical University
  •  トランスジェニックマウスを用いた心筋細胞におけるチロシンキナーゼLTKの機能の解析

    • Principal Investigator
      本田 浩章
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  Tecキナーゼを介する細胞増殖機構Principal Investigator

    • Principal Investigator
      間野 博行
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Jichi Medical University
  •  サイトカインの細胞内情報伝達とTecチロシンキナーゼPrincipal Investigator

    • Principal Investigator
      間野 博行
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Jichi Medical University
  •  Development of a novel gene therapy technology for site-specific integration of large-sized genes

    • Principal Investigator
      OZAWA Keiya
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Jichi Medical School
  •  Development of a novel approach to hepatocellular carcinomaPrincipal Investigator

    • Principal Investigator
      MANO Hiroyuki
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Jichi Medical School
  •  造血幹細胞増殖機構におけるTecチロシンキナーゼの解析Principal Investigator

    • Principal Investigator
      間野 博行
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Jichi Medical University
  •  造血幹細胞への遺伝子導入のためのレトロウイルスベクター産生システムの改良

    • Principal Investigator
      OZAWA Keiya
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Jichi Medical University
  •  トランスジェニックマウスを用いたp210^<bcr/abl>の機能解析

    • Principal Investigator
      本田 浩章
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Jichi Medical University
  •  Tecキナーゼを介する細胞増殖機構Principal Investigator

    • Principal Investigator
      間野 博行
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Jichi Medical University
  •  細胞接着・転移におけるCas/Fakの相互作用

    • Principal Investigator
      堺 隆一
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Jichi Medical University
  •  サイトカイン補充遺伝子療法のための自殺遺伝子を介した細胞レベルでの調節法の開発

    • Principal Investigator
      小澤 敬也
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Jichi Medical University
  •  自殺遺伝子を用いた新しい肝細胞がん遺伝子治療法の開発Principal Investigator

    • Principal Investigator
      間野 博行
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Jichi Medical University
  •  細胞がん化におけるP130^<cas>の役割

    • Principal Investigator
      堺 隆一
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      Jichi Medical University
  •  Anolysis of a novel protein-tyrosine phosphatase in hemotopoietic system

    • Principal Investigator
      HONDA Hiroaki
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      UNIVERSITY OF TOKYO
      Jichi Medical University
  •  造血幹細胞におけるTecチロシンキナーゼの解析Principal Investigator

    • Principal Investigator
      間野 博行
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Jichi Medical University
  •  Tecチロシンキナーゼを介する細胞増殖機構Principal Investigator

    • Principal Investigator
      間野 博行
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Jichi Medical University
  •  Molecular study of hematopoiesis-supporting ability of C3H10T1/2 mouse embryo fibroblasts

    • Principal Investigator
      OZAWA Keiya
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Jichi Medical School
  •  血小板由来血管内皮細胞増殖因子の生理的意義の解析

    • Principal Investigator
      豊島 秀男
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  造血細胞特異的受容体型チロシンキナーゼ,ltkに対する増殖因子と生理的意義の解析

    • Principal Investigator
      豊島 秀男
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      The University of Tokyo
  •  A novel gene therapy against human leukemias : suppression of protein-tyrosine kinase activitiesPrincipal Investigator

    • Principal Investigator
      MANO Hiroyuki
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Jichi Medical School
      The University of Tokyo
  •  血小板由来血管内細胞増殖因子の生理的意義の解析

    • Principal Investigator
      TOYOSHIMA Hideo
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  Development and clinical application of molecular diagnosis in leukemias

    • Principal Investigator
      HIRAI Hisamaru
    • Project Period (FY)
      1992 – 1994
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      University of Tokyo
  •  Analysis of signal transduction mechanism through a novel tyrosine kinase receptor

    • Principal Investigator
      HIRAI Hisamaru
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      The University of Tokyo

All 2010 2009 2008 2007 2006 2005

All Journal Article Presentation

  • [Journal Article] Tec protein tyrosine kinase inhibits CD25 expression in human T-lymphocyte2010

    • Author(s)
      Susaki K, Kitanaka A, Dobashi H, Kubota Y, Kittaka K, Kameda T, Yamaoka G, Mano H, Mihara K, Ishida T.
    • Journal Title

      Immunol Lett 127

      Pages: 135-142

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019060
  • [Journal Article] Array-based genomic resequencing of human leukemia2010

    • Author(s)
      Yamashita Y, Yuan J, Suetake I, Suzuki H, Ishikawa Y, Choi YL, Ueno T, Soda M, Hamada T, Haruta H, Takada S, Miyazaki Y, Kiyoi H, Ito E, Naoe T, Tomonaga M, Toyota M, Tajima S, Iwama A, Mano H.
    • Journal Title

      Oncogene (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019060
  • [Journal Article] Schedule-dependent synergism and antagonism between pemetrexed and docetaxel in human lung cancer cell lines in vitro2009

    • Author(s)
      Kano Y, Tanaka M, Akutsu M, Mori K, Yazawa Y, Mano H, Furukawa Y.
    • Journal Title

      Cancer Chemother Pharmacol 64

      Pages: 1129-1137

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019060
  • [Journal Article] KIF5B-ALK, a novel fusion oncokinase identified by an immunohistochemistry-based diagnostic system for ALK-positive lung cancer2009

    • Author(s)
      Takeuchi K, Choi YL, Togashi Y, Soda M, Hatano S, Inamura K, Takada S, Ueno T, Yamashita Y, Satoh Y, Okumura S, Nakagawa K, Ishikawa Y, Mano H.
    • Journal Title

      Clin Cancer Res 15

      Pages: 3143-3149

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019060
  • [Journal Article] Potential role of miR-29b in modulation of Dnmt3a and Dnmt3b expression in primordial germ cells of female mouse embryos2009

    • Author(s)
      Takada S, Berezikov E, Choi YL, Yamashita Y, Mano H.
    • Journal Title

      RNA 15

      Pages: 1507-1514

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019060
  • [Journal Article] Genome-wide histone methylation profile for heart failure2009

    • Author(s)
      Kaneda R, Takada S, Yamashita Y, Choi YL, Nonaka-Sarukawa M, Soda M, Misawa Y, Isomura T, Shimada K, Mano H.
    • Journal Title

      Genes Cells 14

      Pages: 69-77

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019060
  • [Journal Article] High-resolution analysis of chromosome copy number alterations in angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma, unspecified, with single nucleotide polymorphism-typing microarrays2008

    • Author(s)
      Fujiwara SI, Yamashita Y, Nakamura N, Choi YL, Ueno T, Watanabe H, Kurashina K, Soda M, Enomoto M, Hatanaka H, Takada S, Abe M, Ozawa K, Mano H.
    • Journal Title

      Leukemia 22

      Pages: 1891-1898

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019060
  • [Journal Article] Non-solid oncogenes in solid tumors: EML4-ALK fusion genes in lung cancer2008

    • Author(s)
      Mano H.
    • Journal Title

      Cancer Sci 99

      Pages: 2349-2355

    • NAID

      10024013752

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019060
  • [Journal Article] Oncogenic mutations of ALK kinase in neuroblastoma2008

    • Author(s)
      Chen Y, Takita J, Choi YL, Kato M, Ohira M, Sanada M, Wang L, Soda M, Kikuchi A, Igarashi T, Nakagawara A, Hayashi Y, Mano H, Ogawa S.
    • Journal Title

      Nature 455

      Pages: 971-974

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019060
  • [Journal Article] Multiplex reverse transcription-PCR screening for EML4-ALK fusion transcripts2008

    • Author(s)
      Takeuchi K, Choi YL, Soda M, Inamura K, Togashi Y, Hatano S, Enomoto M, Takada S, Yamashita Y, Satoh Y, Okumura S, Nakagawa K, Ishikawa Y, Mano H.
    • Journal Title

      Clin Cancer Res 14

      Pages: 6618-6624

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019060
  • [Journal Article] A mouse model for EML4-ALK-positive lung cancer2008

    • Author(s)
      Soda M, Takada S, Takeuchi K, Choi YL, Enomoto M, Ueno T, Haruta H, Hamada T, Yamashita Y, Ishikawa Y, Sugiyama Y, Mano H.
    • Journal Title

      Proc Natl Acad Sci U S A 105

      Pages: 19893-19897

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019060
  • [Journal Article] MicroRNA expression profiles of human leukemias2008

    • Author(s)
      Takada S, Yamashita Y, Berezikov E, Hatanaka H, Fujiwara SI, Kurashina K, Watanabe H, Enomoto M, Soda M, Choi YL, Mano H.
    • Journal Title

      Leukemia 22

      Pages: 1274-1278

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019060
  • [Journal Article] Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer2008

    • Author(s)
      Choi YL, Takeuchi K, Soda M, Inamura K, Togashi Y, Hatano S, Enomoto M, Hamada T, Haruta H, Watanabe H, Kurashina K, Hatanaka H, Ueno T, Takada S, Yamashita Y, Sugiyama Y, Ishikawa Y, Mano H.
    • Journal Title

      Cancer Res 68

      Pages: 4971-4976

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019060
  • [Journal Article] Functional analysis of JAK3 mutations in transient myeloproliferative disorder and acute megakaryoblastic leukaemia accompanying Down syndrome" Br2008

    • Author(s)
      Sato T, Toki T, Kanezaki R, Xu G, Terui K, Kanegane H, Miura M, Adachi S, Migita M, Morinaga S, Nakano T, Endo M, Kojima S, Kiyoi H, Mano H, Ito E.
    • Journal Title

      J Haematol 141

      Pages: 681-688

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019060
  • [Journal Article] mRAP, a sensitive method for determination of microRNA expression profiles2007

    • Author(s)
      Mano H, Takada S
    • Journal Title

      Methods 43

      Pages: 118-122

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019060
  • [Journal Article] Analysis of chromosome copy number in leukemic cells by different microarray platforms2007

    • Author(s)
      Yamashita Y, Minoura K, Taya T, Fujiwara SI, Kurashina K, Watanabe H, Choi YL, Soda M, Hatanaka H, Enomoto M, Takada S, Mano H.
    • Journal Title

      Leukemia 21

      Pages: 1333-1337

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019060
  • [Journal Article] Profiling of microRNA expression by mRAP2007

    • Author(s)
      Takada S, Mano H
    • Journal Title

      Nature Protocols 2

      Pages: 3136-3145

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019060
  • [Journal Article] Transforming activity of purinergic receptor P2Y, G-protein coupled, 2 revealed by retroviral expression screening" Biochem2007

    • Author(s)
      Hatanaka H, Takada S, Choi YL, Fujiwara S, Soda M, Enomoto M, Kurashina K, Watanabe H, Yamashita Y, Sugano K, Mano H.
    • Journal Title

      Biophys Res Commun 356

      Pages: 723-726

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019060
  • [Journal Article] Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer2007

    • Author(s)
      Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, Ishikawa S, Fujiwara S, Watanabe H, Kurashina K, Hatanaka H, Bando M, Ohno S, Ishikawa Y, Aburatani H, Niki T, Sohara Y, Sugiyama Y, Mano H.
    • Journal Title

      Nature 448

      Pages: 561-566

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019060
  • [Journal Article] A genomic analysis of adult T-cell leukemia2007

    • Author(s)
      Choi YL, Tsukasaki K, O'Neill M C, Yamada Y, Onimaru Y, Matsumoto K, Ohashi J, Yamashita Y, Tsutsumi S, Kaneda R, Takada S, Aburatani H, Kamihira S, Nakamura T, Tomonaga M, Mano H.
    • Journal Title

      Oncogene 26

      Pages: 1245-1255

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019060
  • [Journal Article] Divergent cytotoxic effects of PKC412 in combination with conventional antileukemic agents in FLT3 mutation-positive versus -negative leukemia cell lines2007

    • Author(s)
      Furukawa Y, Vu HA, Akutsu M, Odgerel T, Izumi T, Tsunoda S, Matsuo Y, Kirito K, Sato Y, Mano H, Kano Y.
    • Journal Title

      Leukemia 21

      Pages: 1005-1014

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019060
  • [Journal Article] Transforming activity of purinergic receptor P2Y, G protein coupled, 8 revealed by retroviral expression screening2007

    • Author(s)
      Fujiwara S, Yamashita Y, Choi YL, Watanabe H, Kurashina K, Soda M, Enomoto M, Hatanaka H, Takada S, Ozawa K, Mano H.
    • Journal Title

      Leuk Lymphoma 48

      Pages: 978-986

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019060
  • [Journal Article] Identification of a constitutively active mutant of JAK3 by retroviral expression screening2007

    • Author(s)
      Choi YL, Kaneda R, Wada T, Fujiwara S, Soda M, Watanabe H, Kurashina K, Hatanaka H, Enomoto M, Takada S, Yamashita Y, Mano H.
    • Journal Title

      Leuk Res 31

      Pages: 203-209

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019060
  • [Journal Article] mRAP, a sensitive method for determination of microRNA expression profiles2007

    • Author(s)
      Mano H, Takada S.
    • Journal Title

      Methods 43

      Pages: 118-122

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019060
  • [Journal Article] Profiling of microRNA expression by mRAP2007

    • Author(s)
      Takada S, Mano H.
    • Journal Title

      Nat Protoc 2

      Pages: 3136-3145

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019060
  • [Journal Article] DNA microarray analysis of myelodysplastic syndrome2006

    • Author(s)
      Mano H.
    • Journal Title

      Leuk Lymphoma 47

      Pages: 9-14

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019060
  • [Journal Article] DNA microarray analysis of myelodysplastic syndrome2006

    • Author(s)
      Mano H
    • Journal Title

      Leuk Lymphoma 47

      Pages: 9-14

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17019060
  • [Journal Article] Schedule-dependent interactions between pemetrexed and cisplatin in human carcinoma cell lines in vitro2006

    • Author(s)
      Kano Y, Akutsu M, Tsunoda S, Izumi T, Kobayashi H, Inoue K, Mori K, Fujii H, Mano H, Odgerel T, Furukawa Y.
    • Journal Title

      Oncol Res 16

      Pages: 85-95

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019060
  • [Journal Article] Mouse microRNA profiles determined with a new and sensitive cloning method2006

    • Author(s)
      Takada S, Berezikov E, Yamashita Y, Lagos-Quintana M, Kloosterman WP, Enomoto M, Hatanaka H, Fujiwara S, Watanabe H, Soda M, Choi YL, Plasterk RH, Cuppen E, Mano H.
    • Journal Title

      Nucleic Acids Res 34

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019060
  • [Journal Article] Signals from intra-abdominal fat modulate insulin and leptin sensitivity through different mechanisms: neuronal involvement in food-intake regulation2006

    • Author(s)
      Yamada T, Katagiri H, Ishigaki Y, Ogihara T, Imai J, Uno K, Hasegawa Y, Gao J, Ishihara H, Niijima A, Mano H, Aburatani H, Asano T, Oka Y.
    • Journal Title

      Cell Metab 3

      Pages: 223-229

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019060
  • [Journal Article] Epigenetic silencing of AXIN2 in colorectal carcinoma with microsatellite instability2006

    • Author(s)
      Koinuma K, Yamashita Y, Liu W, Hatanaka H, Kurashina K, Wada T, Takada S, Kaneda R, Choi YL, Fujiwara SI, Miyakura Y, Nagai H, Mano H.
    • Journal Title

      Oncogene 25

      Pages: 139-146

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019060
  • [Journal Article] Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis2006

    • Author(s)
      Berezikov E, van Tetering G, Verheul M, van de Belt J, van Laake L, Vos J, Verloop R, van de Wetering M, Guryev V, Takada S, van Zonneveld AJ, Mano H, Plasterk R, Cuppen E.
    • Journal Title

      Genome Res 16

      Pages: 1289-1298

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019060
  • [Journal Article] Expression of the myeloperoxidase gene in AC133 positive leukemia cells relates to the prognosis of acute myeloid leukemia2006

    • Author(s)
      Taguchi J, Miyazaki Y, Tsutsumi C, Sawayama Y, Ando K, Tsushima H, Fukushima T, Hata T, Yoshida S, Kuriyama K, Honda S, Jinnai I, Mano H, Tomonaga M.
    • Journal Title

      Leuk Res 30

      Pages: 1105-1112

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019060
  • [Journal Article] Experimental trial for diagnosis of pancreatic ductal carcinoma based on gene expression profiles of pancreatic ductal cells2005

    • Author(s)
      Ishikawa M, Yoshida K, Yamashita Y, Ota J, Takada S, Kisanuki H, Koinuma K, Choi YL, Kaneda R, Iwao T, Tamada K, Sugano K, Mano H.
    • Journal Title

      Cancer Sci 96

      Pages: 387-393

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019060
  • [Journal Article] Retroviral expression screening of oncogenes in natural killer cell leukemia2005

    • Author(s)
      Choi YL, Moriuchi R, Osawa M, Iwama A, Makishima H, Wada T, Kisanuki H, Kaneda R, Ota J, Koinuma K, Ishikawa M, Takada S, Yamashita Y, Oshimi K, Mano H.
    • Journal Title

      Leuk Res 29

      Pages: 943-949

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019060
  • [Journal Article] Screening for genomic fragments that are methylated specifically in colorectal carcinoma with a methylated MLH1 promoter2005

    • Author(s)
      Koinuma K, Kaneda R, Toyota M, Yamashita Y, Takada S, Choi YL, Wada T, Okada M, Konishi F, Nagai H, Mano H.
    • Journal Title

      Carcinogenesis 26

      Pages: 2078-2085

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019060
  • [Journal Article] Genome-wide screening for target regions of histone deacetylases in cardiomyocytes2005

    • Author(s)
      Kaneda R, Ueno S, Yamashita Y, Choi YL, Koinuma K, Takada S, Wada T, Shimada K, Mano H.
    • Journal Title

      Circ Res 97

      Pages: 210-218

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17019060
  • [Presentation] 高感度miRNAプロファイリング法(mRAP)による癌細胞解析2007

    • Author(s)
      高田修治、間野博行
    • Organizer
      日本癌学会学術総会
    • Place of Presentation
      横浜(神奈川県)
    • Year and Date
      2007-10-04
    • Data Source
      KAKENHI-PROJECT-17019060
  • 1.  HONDA Hiroaki (40245064)
    # of Collaborated Projects: 11 results
    # of Collaborated Products: 0 results
  • 2.  SAKAI Ryuichi (40215603)
    # of Collaborated Projects: 11 results
    # of Collaborated Products: 0 results
  • 3.  OZAWA Keiya (30137707)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 2 results
  • 4.  HIRAI Hisamaru (90181130)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 5.  TOYOSHIMA Hideo (20197966)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 6.  MITANI Kinuko (50251244)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 7.  CHIBA Shigeru
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 8.  HANAZONO Yutaka (70251246)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 9.  MIYAZONO Kohei (90209908)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  URABE Masashi (40213516)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  梶井 英治 (40204391)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  島田 和幸 (90145128)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 13.  AKIYAMA Tetsu (70150745)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  FUJITA Naoya (20280951)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  TAKAKURA Nobuyuki (80291954)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  SATO Yasufumi (50178779)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  YANO Seiji (30294672)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  KONDOH Shinae (40314182)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  MINAMI Takashi (00345141)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  HEISSIG Beate (30372931)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  TABATA Yasuhiko (50211371)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  ABURATANI Hiroyuki (10202657)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  NAKA Kazuhito (70372688)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  HARA Eiji (80263268)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  NOJI Hideyoshi (20347214)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  SHICHISHIMA Tsutomu (10192105)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  FUJITA Teizo (20134223)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  TANAKA Tomoyuki (50227154)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  KUME Akihiro (10264293)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  MIZUKAMI Hiroaki (20311938)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  OKADA Takashi (00326828)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  TOMONAGA Masao (40100854)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  MIYAZAKI Yasushi (40304943)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 34.  YAMASHITA Yoshihiro (10326861)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 21 results
  • 35.  萩原 弘一 (00240705)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 36.  山田 信博 (40200729)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 37.  宮川 清 (40200133)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 38.  臼杵 憲祐
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 39.  杉本 耕一
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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