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Yamamoto Takashi  山本 卓

… Alternative Names

YAMAMOTO Takashi  山本 卓

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Researcher Number 90244102
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-6516-2903
External Links
Affiliation (Current) 2025: 広島大学, 統合生命科学研究科(理), 教授
Affiliation (based on the past Project Information) *help 2019 – 2024: 広島大学, 統合生命科学研究科(理), 教授
2014 – 2018: 広島大学, 理学研究科, 教授
2015 – 2017: 広島大学, 大学院理学研究科, 教授
2012 – 2016: 広島大学, 理学(系)研究科(研究院), 教授
2013: 広島大学, 大学院理学研究科, 教授 … More
2007 – 2011: Hiroshima University, Graduate School of Science, Professor
2005 – 2006: 広島大学, 大学院理学研究科, 教授
2004 – 2005: 広島大学, 大学院・理学研究科, 教授
2003: 広島大学, 大学院・理学研究科, 助教授
2002: 広島大学, 大学院・理学研究科, 講師
2001: Kumamoto Univ., Fac. of Sci., Research Associate, 大学院・自然科学研究科, 助手
2001: 熊本大学, 理学部・生物化学科, 助手
2001: 熊本大学, 理学部・生物科学科, 助手
1998 – 2000: 熊本大学, 理学部, 助手
1998: 熊本大学, 理学部生物科学科, 助手
1997: 熊本大学, 自然科学研究科, 助手
1993 – 1996: 熊本大学, 理学部, 助手 Less
Review Section/Research Field
Principal Investigator
Developmental biology / Developmental biology / Medical genome science / System genome science / Biological Sciences
Except Principal Investigator
Developmental biology / Integrative animal science / Pediatrics / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields / Medium-sized Section 63:Environmental analyses and evaluation and related fields … More / Functional basic dentistry / Orthodontics/Pediatric dentistry / Risk sciences of radiation and chemicals / Basic / Social brain science / Biological pharmacy / Insect science / Laboratory animal science / Biological Sciences Less
Keywords
Principal Investigator
発生・分化 / 発現制御 / ゲノム / 遺伝子 / ゲノム編集 / バイオテクノロジー / ゆらぎ / 棘皮動物 / 減数分裂 / 精子形成 … More / イモリ / SNP / 疾患モデル細胞 / 疾患モデル / genome / regulation of expression / development / gene / 転写調節因子 / 発生分化 / 人工ヌクレアーゼ / 発生制御 / 細胞分化 / 新口動物 / 転写因子 / シス調節領域 / 転写調節 / 進化 / 誘導 / 分泌性因子 / ウニ / オーガナイザー / クローニング / cDNA / 受容体 / 両生類 / 遺伝子発現 / アンタゴニスト / 骨形成タンパク質 / 分化 / 増殖 / 精原細胞 / 増殖分化因子 / 刺激分裂 / 遺伝子クローニング / 増殖・分化因子 / シグナルトラップ / アネキシン … More
Except Principal Investigator
FSH / ゲノム編集 / 精原細胞 / 減数分裂開始 / 精子分化 / 人工ヌクレアーゼ / セルトリ細胞 / 第一精母細胞 / 遺伝子 / TALEN / cDNAクローニング / 発生・分化 / BMP-2 / c-kit / SCF / newt / cycloheximide / プロラクチン / アポトーシス / イモリ / spermatogonia / meiosis initiation / Activin A / JAK 1 / Annexin V / iPS細胞 / バイオテクノロジー / activin A / cDNA / JAK1 / アネキシン / 糖鎖抗原 / 制御性B細胞 / 癌免疫回避 / 移植免疫 / ネオアンチゲン / B細胞 / 免疫回避 / 腫瘍免疫 / 放射線感受性 / ゲノム編集技術 / FIB-SEM技術 / 染色体微細構造 / 集束イオンビーム-走査電子顕微鏡 / FIBーSEM / BubR1 / UFB構造 / 変異 / 骨形成 / 歯学 / 歯根 / 点変異 / Runx2 / 膜性骨化 / ゲノム / 核酸 / 核酸導入 / 受精卵 / マウス / ニワトリ / CRISPR/Cas9 / 発生工学 / 応用動物 / ノックアウト / HEMGEN / 始原生殖細胞 / 多能性幹細胞 / 性決定 / 鳥類 / 全エクソーム解析 / カンジダ / CMC / RORC / IL-17 / 原発性免疫不全症 / 機能獲得型変異 / STAT1 / 疾患モデルマウス / 造血細胞移植 / IL17RA / STAT1機能獲得型変異 / 慢性皮膚粘膜カンジダ症 / エレクトポレーション / ノックイン / CRISPR/Casシステム / 組織幹細胞 / in vivo / GFP / リスク評価 / 放射線 / 突然変異 / 環境 / ゲノム解析 / 環境変異原 / 遺伝影響評価 / 生殖細胞突然変異 / 体細胞突然変異 / トランスジェニックメダカ / ノックインマウス / 放射線誘発突然変異 / 4 / Apoptosis / Spermatogonia / Meiosis initiation / BMP受容体 / -4 / 精子形成 / BMP-2,-4 / checkpoint / prolactin / apoptosis / FSH受容体 / RT-PCR / プロラクチン受容体 / チェックポイント / Sertoli cells / spermatogenesis / 遺伝性脊髄小脳変性症 / 神経科学 / 脳神経疾患 / Ca チャンネル / 脊髄小脳変性症 / 遺伝子修正 / ウェルナー症候群 / 遺伝子修復 / 遺伝子編集 / 先天性好中球減少症 / オーミクス / 昆虫 / 遺伝子発現系 / RNAi / 乾燥耐性 / TALENs / 遺伝子改変 / ラット / 実験動物 / ゲノム損傷 / DNA修復 / グノム損傷 / 抗がん剤 / FSH recepter / IGF-I / 培養 Less
  • Research Projects

    (32 results)
  • Research Products

    (157 results)
  • Co-Researchers

    (71 People)
  •  Elucidation of the mechanism of cancer immune evasion by glycan-responsive B cells and development of regulatory methods

    • Principal Investigator
      大段 秀樹
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
    • Research Institution
      Hiroshima University
  •  Morphological characteristics of the genome stress-induced chromosomal tether structure

    • Principal Investigator
      Miyamoto Tatsuo
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 63:Environmental analyses and evaluation and related fields
    • Research Institution
      Yamaguchi University
      Hiroshima University
  •  Development of genome editing platform technology for various disease modelsPrincipal Investigator

    • Principal Investigator
      YAMAMOTO TAKASHI
    • Project Period (FY)
      2017 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Medical genome science
    • Research Institution
      Hiroshima University
  •  Investigation of molecular mechanism and therapeutic target of Chronic Mucocutaneous Candidiasis

    • Principal Investigator
      OKADA SATOSHI
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      Hiroshima University
  •  Establishment of a new mouse model of cledocranial dysplasia by TALEN mediated genome editing

    • Principal Investigator
      Shukunami Chisa
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Functional basic dentistry
    • Research Institution
      Hiroshima University
  •  Application of lipofection-mediated genome editing in mouse zygotes created by IVF via ultra-superovulation

    • Principal Investigator
      Nakagata Naomi
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Integrative animal science
    • Research Institution
      Kumamoto University
  •  Study of cerebellum disturbance by genetic approaches

    • Principal Investigator
      Kawakami Hideshi
    • Project Period (FY)
      2014 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Basic / Social brain science
    • Research Institution
      Hiroshima University
  •  Development of a novel genome editing-mediated gene knock-in systemPrincipal Investigator

    • Principal Investigator
      Yamamoto Takashi
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      System genome science
    • Research Institution
      Hiroshima University
  •  Functional identification of anhydrobiosis-related genes using genome editing technology

    • Principal Investigator
      Kikawada Takahiro
    • Project Period (FY)
      2013 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Insect science
    • Research Institution
      National Agriculture and Food Research Organization
      National Institute of Agrobiological Sciences
  •  Gene editing of iPS cells derived from patients with congenital phagocytic disorders

    • Principal Investigator
      Kobayashi Masao
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      Hiroshima University
  •  Gene correction in iPS cells of premature aging syndrome toward clinical application by genome editing

    • Principal Investigator
      SHIMAMOTO Akira
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Biological pharmacy
    • Research Institution
      Hiroshima University
  •  In vivo, in situ assessment of the mutagenic risk of radiation and environmental chemicals, using newly developed animal systems

    • Principal Investigator
      NODA Asao
    • Project Period (FY)
      2013 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Risk sciences of radiation and chemicals
    • Research Institution
      Radiation Effects Research Foundation
  •  Super-simplification of the genetically modified mouse production method using TALEN

    • Principal Investigator
      YASUE Akihiro
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Orthodontics/Pediatric dentistry
    • Research Institution
      The University of Tokushima
  •  Development of genome editing technology in birds

    • Principal Investigator
      Horiuchi Hiroyuki
    • Project Period (FY)
      2013 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Integrative animal science
    • Research Institution
      Hiroshima University
  •  Development of universal method for genome modification using zinc finger nucleasePrincipal Investigator

    • Principal Investigator
      YAMAMOTO Takashi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Developmental biology
    • Research Institution
      Hiroshima University
  •  Production of knockout rats using TALENs

    • Principal Investigator
      KANEKO Takehito
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Laboratory animal science
    • Research Institution
      Kyoto University
  •  Quantitative analysis of cell-cell interaction responsible for the robustness of developmentPrincipal Investigator

    • Principal Investigator
      YAMAMOTO Takashi
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Developmental biology
    • Research Institution
      Hiroshima University
  •  抗がん剤が誘発する巨大DNA付加体の修復と致死効果

    • Principal Investigator
      井出 博
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Hiroshima University
  •  Gene expression noise during cell differentiation and its regulationPrincipal Investigator

    • Principal Investigator
      YAMAMOTO Takashi
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
    • Research Field
      Developmental biology
    • Research Institution
      Hiroshima University
  •  Studies on the gene network responsible for the specific gene expression during developmentPrincipal Investigator

    • Principal Investigator
      YAMAMOTO Takashi
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Developmental biology
    • Research Institution
      Hiroshima University
  •  棘皮動物Otx遺伝子の転写調節機構の解明Principal Investigator

    • Principal Investigator
      山本 卓
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Hiroshima University
  •  棘皮動物オーガナイザー因子の同定Principal Investigator

    • Principal Investigator
      山本 卓
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Developmental biology
    • Research Institution
      Hiroshima University
  •  精原細胞の増殖と分化における骨形成タンパク質(BMP)の働きPrincipal Investigator

    • Principal Investigator
      山本 卓
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Developmental biology
    • Research Institution
      Kumamoto University
  •  Switching Mechanism for Meiosis Initiation or Apoptosis in Spermatogonia

    • Principal Investigator
      ABE Shin-ichi
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Developmental biology
    • Research Institution
      Kumamoto University
  •  シグナルトラップ法を用いたイモリ精巣からの増殖・分化因子のクローニングPrincipal Investigator

    • Principal Investigator
      山本 卓
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Developmental biology
    • Research Institution
      Kumamoto University
  •  Mechanism of apoptosis induction in amphibian spermatogonia by prolactin

    • Principal Investigator
      ABE Shin-ichi
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Developmental biology
    • Research Institution
      Kumamoto University
  •  両生類精巣における成長因子の探索と精子分化に対するその生理活性

    • Principal Investigator
      安部 真一
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Developmental biology
    • Research Institution
      Kumamoto University
  •  減数分裂誘導因子の研究

    • Principal Investigator
      安部 眞一
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kumamoto University
  •  カルシウム結合蛋白質アネキシンの減数分裂における働きPrincipal Investigator

    • Principal Investigator
      山本 卓
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Developmental biology
    • Research Institution
      Kumamoto University
  •  減数分裂誘導因子の研究

    • Principal Investigator
      阿部 眞一
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kumamoto University
  •  減数分裂誘導因子の研究

    • Principal Investigator
      ABE Shinich
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kumamoto University
  •  Analysis of the mechanism underlying meiosis initiation using in vitro culture system.

    • Principal Investigator
      ABE Shinich
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Developmental biology
    • Research Institution
      Kumamoto University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2004 Other

All Journal Article Presentation Book Patent

  • [Book] ゲノム編集と医学・医療への応用2022

    • Author(s)
      山本卓, 宮本達雄, 一戸辰夫, 本庶仁子, 大森司, 加藤和人
    • Total Pages
      200
    • Publisher
      裳華房
    • ISBN
      9784785358730
    • Data Source
      KAKENHI-PROJECT-20K21845
  • [Book] ゲノム編集とはなにか2020

    • Author(s)
      山本 卓
    • Total Pages
      240
    • Publisher
      講談社
    • ISBN
      9784065194690
    • Data Source
      KAKENHI-PROJECT-17H01409
  • [Book] 完全版 ゲノム編集実験スタンダード2019

    • Author(s)
      山本 卓、佐久間哲史
    • Total Pages
      386
    • Publisher
      羊土社
    • ISBN
      9784758122443
    • Data Source
      KAKENHI-PROJECT-17H01409
  • [Book] ゲノム編集の基本原理と応用2018

    • Author(s)
      山本 卓
    • Total Pages
      176
    • Publisher
      裳華房
    • ISBN
      9784785358693
    • Data Source
      KAKENHI-PROJECT-17H01409
  • [Book] ゲノム編集入門2016

    • Author(s)
      山本 卓
    • Total Pages
      20
    • Publisher
      裳華房
    • Data Source
      KAKENHI-PROJECT-26290070
  • [Journal Article] High-efficient CRISPR/Cas9-mediated gene targeting to establish cell models of ciliopathies2023

    • Author(s)
      Hosoba Kosuke、Morita Tomoka、Zhang Ying、Kishi Hiroko、Yamamoto Takashi、Miyamoto Tatsuo
    • Journal Title

      Methods in Cell Biology

      Volume: 175 Pages: 85-95

    • DOI

      10.1016/bs.mcb.2022.07.020

    • ISBN
      9780443185861
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21H02718, KAKENHI-PROJECT-20K07261, KAKENHI-PROJECT-20K21845, KAKENHI-PROJECT-21K06782
  • [Journal Article] Cholesterol in the ciliary membrane as a therapeutic target against cancer2023

    • Author(s)
      Kimura Sotai、Morita Tomoka、Hosoba Kosuke、Itoh Hiroshi、Yamamoto Takashi、Miyamoto Tatsuo
    • Journal Title

      Frontiers in Molecular Biosciences

      Volume: 10 Pages: 1160415-1160415

    • DOI

      10.3389/fmolb.2023.1160415

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21H02718, KAKENHI-PROJECT-20K21845
  • [Journal Article] NBS1 I171V variant underlies individual differences in chromosomal radiosensitivity within human populations2021

    • Author(s)
      Tomioka K, Miyamoto T, Akutsu SN, Yanagihara H, Fujita K, Royba E, Tauchi H, Yamamoto T, Koh I, Hirata E, Kudo Y, Kobayashi M, Okada S, Matsuura S
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 1-13

    • DOI

      10.1038/s41598-021-98673-7

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K22515, KAKENHI-PROJECT-19K16520, KAKENHI-PROJECT-19H03620, KAKENHI-PROJECT-19H04270, KAKENHI-PROJECT-21H02718, KAKENHI-PROJECT-20K21845
  • [Journal Article] Genome-wide kinetic properties of transcriptional bursting in mouse embryonic stem cells2020

    • Author(s)
      Ochiai Hiroshi、Hayashi Tetsutaro、Umeda Mana、Yoshimura Mika、Harada Akihito、Shimizu Yukiko、Nakano Kenta、Saitoh Noriko、Liu Zhe、Yamamoto Takashi、Okamura Tadashi、Ohkawa Yasuyuki、Kimura Hiroshi、Nikaido Itoshi
    • Journal Title

      Science Advances

      Volume: 6 Issue: 25

    • DOI

      10.1126/sciadv.aaz6699

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K06612, KAKENHI-PROJECT-20K21398, KAKENHI-PLANNED-18H05527, KAKENHI-PUBLICLY-19H05244, KAKENHI-PUBLICLY-19H05425, KAKENHI-PUBLICLY-20H04846, KAKENHI-PUBLICLY-20H05368, KAKENHI-PROJECT-17H01409, KAKENHI-PROJECT-20H00456, KAKENHI-PROJECT-19H03211, KAKENHI-PROJECT-20H03520, KAKENHI-PROJECT-18K19310, KAKENHI-PLANNED-18H05531, KAKENHI-PROJECT-19H03424
  • [Journal Article] Single-gene imaging links genome topology, promoter?enhancer communication and transcription control2020

    • Author(s)
      Li Jieru、Hsu Angela、Hua Yujing、Wang Guanshi、Cheng Lingling、Ochiai Hiroshi、Yamamoto Takashi、Pertsinidis Alexandros
    • Journal Title

      Nature Structural & Molecular Biology

      Volume: 27 Issue: 11 Pages: 1032-1040

    • DOI

      10.1038/s41594-020-0493-6

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06612, KAKENHI-PROJECT-17H01409, KAKENHI-PLANNED-18H05531
  • [Journal Article] Insufficiency of ciliary cholesterol in hereditary Zellweger syndrome.2020

    • Author(s)
      Miyamoto T, Hosoba K, Itabashi T, Iwane AH, Akutsu AN, Ochiai H, Saito Y, Yamamoto T, Matsuura S
    • Journal Title

      EMBO Journal

      Volume: - Issue: 12

    • DOI

      10.15252/embj.2019103499

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K06612, KAKENHI-PROJECT-19K06739, KAKENHI-PROJECT-19K22515, KAKENHI-PUBLICLY-18H04979, KAKENHI-PROJECT-18H02624, KAKENHI-PROJECT-19H04270, KAKENHI-PROJECT-17K07372, KAKENHI-PROJECT-19K16521, KAKENHI-PROJECT-17H01409, KAKENHI-PLANNED-18H05531, KAKENHI-ORGANIZER-15H05935, KAKENHI-WRAPUP-20H05615
  • [Journal Article] Anephrogenic phenotype induced by SALL1 gene knockout in pigs.2019

    • Author(s)
      Watanabe M, Nakano K, Uchikura A, Matsunari H, Yashima S, Umeyama K, Takayanagi S, Sakuma T, Yamamoto T, Morita S, Horii T, Hatada I, Nishinakamura R, Nakauchi H, Nagashima H.
    • Journal Title

      Sci Rep.

      Volume: 9 Issue: 1 Pages: 8016-8016

    • DOI

      10.1038/s41598-019-44387-w

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06607, KAKENHI-PROJECT-19K16111, KAKENHI-PROJECT-17H01409
  • [Journal Article] CRISPR-Cas3 induces broad and unidirectional genome editing in human cells2019

    • Author(s)
      Morisaka Hiroyuki、Yoshimi Kazuto、Okuzaki Yuya、Gee Peter、Kunihiro Yayoi、Sonpho Ekasit、Xu Huaigeng、Sasakawa Noriko、Naito Yuki、Nakada Shinichiro、Yamamoto Takashi、Sano Shigetoshi、Hotta Akitsu、Takeda Junji、Mashimo Tomoji
    • Journal Title

      Nature Communications

      Volume: 10 Issue: 1 Pages: 5302-5302

    • DOI

      10.1038/s41467-019-13226-x

    • NAID

      120006848247

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K16025, KAKENHI-PROJECT-17H01409, KAKENHI-PROJECT-18H03974
  • [Journal Article] Single-Molecule Nanoscopy Elucidates RNA Polymerase II Transcription at Single Genes in Live Cells2019

    • Author(s)
      Li Jieru、Dong Ankun、Saydaminova Kamola、Chang Hill、Wang Guanshi、Ochiai Hiroshi、Yamamoto Takashi、Pertsinidis Alexandros
    • Journal Title

      Cell

      Volume: 178 Issue: 2 Pages: 491-506

    • DOI

      10.1016/j.cell.2019.05.029

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06612, KAKENHI-PROJECT-17H01409
  • [Journal Article] Activin Is Superior to BMP7 for Efficient Maintenance of Human iPSC-Derived Nephron Progenitors.2019

    • Author(s)
      Tanigawa S, Naganuma H, Kaku Y, Era T, Sakuma T, Yamamoto T, Taguchi A and Nishinakamura R.
    • Journal Title

      Stem Cell Reports

      Volume: 13 Issue: 2 Pages: 322-337

    • DOI

      10.1016/j.stemcr.2019.07.003

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06264, KAKENHI-PROJECT-19K08707, KAKENHI-PROJECT-19K16111, KAKENHI-PROJECT-17H06177, KAKENHI-PROJECT-17H01409
  • [Journal Article] Three-Component Repurposed Technology for Enhanced Expression: Highly Accumulable Transcriptional Activators via Branched Tag Arrays2018

    • Author(s)
      Kunii A, Hara Y, Takenaga M, Hattori N, Fukazawa T, Ushijima T, Yamamoto T, Sakuma T.
    • Journal Title

      CRISPR J

      Volume: 1 Issue: 5 Pages: 337-347

    • DOI

      10.1089/crispr.2018.0009

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H01409
  • [Journal Article] Microhomology-assisted scarless genome editing in human iPSCs2018

    • Author(s)
      Kim Shin-Il、Matsumoto Tomoko、Kagawa Harunobu、Nakamura Michiko、Hirohata Ryoko、Ueno Ayano、Ohishi Maki、Sakuma Tetsushi、Soga Tomoyoshi、Yamamoto Takashi、Woltjen Knut
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 939-939

    • DOI

      10.1038/s41467-018-03044-y

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K07256, KAKENHI-PROJECT-17H01409, KAKENHI-PROJECT-16K18478
  • [Journal Article] Biased genome editing using the local accumulation of DSB repair molecules system.2018

    • Author(s)
      Nakade S, Mochida K, Kunii A, Nakamae K, Aida T, Tanaka K, Sakamoto N, Sakuma T, Yamamoto T
    • Journal Title

      Nature Communications

      Volume: 9(1) Issue: 1 Pages: 3270-3270

    • DOI

      10.1038/s41467-018-05773-6

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K07241, KAKENHI-PROJECT-18K19494, KAKENHI-PROJECT-17H01409, KAKENHI-PROJECT-17H02216, KAKENHI-PROJECT-16K07085, KAKENHI-PROJECT-17K15045
  • [Journal Article] PLK1-mediated phosphorylation of WDR62/MCPH2 ensures proper mitotic spindle orientation2017

    • Author(s)
      Miyamoto Tatsuo、Akutsu Silvia Natsuko、Fukumitsu Akihiro、Morino Hiroyuki、Masatsuna Yoshinori、Hosoba Kosuke、Kawakami Hideshi、Yamamoto Takashi、Shimizu Kenji、Ohashi Hirofumi、Matsuura Shinya
    • Journal Title

      Human Molecular Genetics

      Volume: 26 Issue: 22 Pages: 4429-4440

    • DOI

      10.1093/hmg/ddx330

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26242085, KAKENHI-PROJECT-15H04321, KAKENHI-PROJECT-15K15017, KAKENHI-PROJECT-15K15083
  • [Journal Article] Culture time of vitrified/warmed zygotes before microinjection affects the production efficiency of CRISPR-Cas9-mediated knock-in mice2017

    • Author(s)
      Nakagawa Y, Sakuma T, Nishimichi N, Yokosaki Y, Takeo T, Nakagata N, Yamamoto T
    • Journal Title

      Biology Open

      Volume: - Pages: 706-713

    • DOI

      10.1242/bio.025122

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K18478, KAKENHI-PROJECT-17K11242, KAKENHI-PROJECT-15H04606, KAKENHI-PROJECT-15K07051, KAKENHI-PROJECT-17H04161
  • [Journal Article] Safety and efficacy of treatment with asfotase alfa in patients with hypophosphatasia: Results from a Japanese clinical trial2017

    • Author(s)
      Kitaoka Taichi、Tajima Toshihiro、Nagasaki Keisuke、Kikuchi Toru、Yamamoto Katsusuke、Michigami Toshimi、Okada Satoshi、Fujiwara Ikuma、Kokaji Masayuki、Mochizuki Hiroshi、Ogata Tsutomu、Tatebayashi Koji、Watanabe Atsushi、Yatsuga Shuichi、Kubota Takuo、Ozono Keiichi
    • Journal Title

      Clin Endocrinol.

      Volume: 87 Issue: 1 Pages: 10-19

    • DOI

      10.1111/cen.13343

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05355, KAKENHI-PROJECT-16K15528
  • [Journal Article] Establishment of expanded and streamlined pipeline of PITCh knock-in - a web-based design tool for MMEJ-mediated gene knock-in, PITCh designer, and the variations of PITCh, PITCh-TG and PITCh-KIKO2017

    • Author(s)
      Nakamae K, Nishimura Y, Takenaga M, Nakade S, Sakamoto N, Ide H, Sakuma T, Yamamoto T
    • Journal Title

      Bioengineered

      Volume: - Issue: 3 Pages: 302-308

    • DOI

      10.1080/21655979.2017.1313645

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16K18478, KAKENHI-PROJECT-17H01409
  • [Journal Article] Rapid and efficient analysis of gene function using CRISPR-Cas9 in Xenopus tropicalis founders2016

    • Author(s)
      Shigeta, Mitsuki; Sakane, Yuto; Iida, Midori; Suzuki, Miyuki; Kashiwagi, Keiko; Kashiwagi, Akihiko; Fujii, Satoshi; Yamamoto, Takashi; Suzuki, Ken-ichi
    • Journal Title

      Genes to Cells

      Volume: in press Issue: 7 Pages: 755-771

    • DOI

      10.1111/gtc.12379

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15J05833, KAKENHI-ORGANIZER-24118001, KAKENHI-PLANNED-24118008, KAKENHI-PROJECT-26290070
  • [Journal Article] Ultra-superovulation for the CRISPR-Cas9-mediated production of gene-knockout, single- amino-acid-substituted, and floxed mice2016

    • Author(s)
      Yoshiko Nakagawa, Tetsushi Sakuma, Norihisa Nishimichi, Yasuyuki Yokosaki, Noriyuki Yanaka, Toru Takeo, Naomi Nakagata and Takashi Yamamoto
    • Journal Title

      Biology Open

      Volume: 5 Issue: 8 Pages: 1142-1148

    • DOI

      10.1242/bio.019349

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04606, KAKENHI-PROJECT-26290070, KAKENHI-PROJECT-26293174, KAKENHI-PROJECT-26660112, KAKENHI-PROJECT-15K07051, KAKENHI-PROJECT-16K18478
  • [Journal Article] MMEJ-assisted gene knock-in using TALENs and CRISPR-Cas9 with the PITCH systems.2016

    • Author(s)
      Sakuma T, Nakade S, Sakane Y, Suzuki K, Yamamoto T.
    • Journal Title

      Nature Protocols

      Volume: 11 Issue: 1 Pages: 118-113

    • DOI

      10.1038/nprot.2015.140

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K06802, KAKENHI-PROJECT-26290070
  • [Journal Article] Gene cassette knock-in in mammalian cells and zygotes by enhanced MMEJ.2016

    • Author(s)
      Aida T, Nakade S, Sakuma T, Izu Y, Oishi A, Mochida K, Ishikubo H, Usami T, Aizawa H, Yamamoto T, Tanaka K.
    • Journal Title

      BMC Genomics

      Volume: 17 Issue: 1 Pages: 979-979

    • DOI

      10.1186/s12864-016-3331-9

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-16H01383, KAKENHI-PLANNED-26112010, KAKENHI-PROJECT-16J03164, KAKENHI-PROJECT-26290021, KAKENHI-PROJECT-26290070, KAKENHI-PROJECT-26430008, KAKENHI-PROJECT-15K19988, KAKENHI-PROJECT-16K07085, KAKENHI-PROJECT-16K18478
  • [Journal Article] Production of knockout mice by DNA microinjection of various CRISPR/Cas9 vectors into freeze-thawed fertilized oocytes2015

    • Author(s)
      Nakagawa Y, Sakuma T, Sakamoto T, Ohmuraya M, Nakagata N, Yamamoto T
    • Journal Title

      BMC Biotechnol

      Volume: - Issue: 1 Pages: 33-33

    • DOI

      10.1186/s12896-015-0144-x

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25890014, KAKENHI-PROJECT-221S0001, KAKENHI-PUBLICLY-26111516, KAKENHI-PROJECT-15H04606
  • [Journal Article] The Expression of TALEN before Fertilization Provides a Rapid Knock-Out Phenotype in Xenopus laevis Founder Embryos.2015

    • Author(s)
      Miyamoto K, Suzuki K, Suzuki M, Sakane Y, Sakuma T, Herberg S, Simeone A, Simpson D, Jullien J, Yamamoto T, Gurdon JB.
    • Journal Title

      PLOS ONE

      Volume: 10(11) Issue: 11 Pages: e0142946-e0142946

    • DOI

      10.1371/journal.pone.0142946

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K06802, KAKENHI-PROJECT-15J05833, KAKENHI-PROJECT-26290070
  • [Journal Article] Unliganded thyroid hormone receptor alpha regulates developmental timing via gene repression in Xenopus tropicalis2015

    • Author(s)
      J. Choi, K. T. Suzuki, T. Sakuma, L. Shewade, T. Yamamoto and D. R. Buchholz
    • Journal Title

      Endocrinology

      Volume: 156 Issue: 2 Pages: 735-44

    • DOI

      10.1210/en.2014-1554

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-ORGANIZER-22124001, KAKENHI-PROJECT-24657156, KAKENHI-PROJECT-25890014
  • [Journal Article] Homologous recombination-independent large gene cassette knock-in in CHO cells using TALEN and MMEJ-directed donor plasmids.2015

    • Author(s)
      Sakuma, T., Takenaga, M., Kawabe, Y., Nakamura, T., Kamihira, M. & Yamamoto, T.
    • Journal Title

      Int. J. Mol. Sci.

      Volume: 16 Issue: 10 Pages: 23849-23866

    • DOI

      10.3390/ijms161023849

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-26117718, KAKENHI-PROJECT-25292219, KAKENHI-PROJECT-26290070
  • [Journal Article] Versatile strategy for isolating TALEN-mediated knockout mutants in Caenorhabditis elegans.2014

    • Author(s)
      Sugi T, Sakuma T, Ohtani T and Yamamoto T
    • Journal Title

      Dev Growth Differ

      Volume: 56 Issue: 1 Pages: 78-85

    • DOI

      10.1111/dgd.12108

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24657156, KAKENHI-PROJECT-25840124, KAKENHI-PROJECT-25890014
  • [Journal Article] TALEN-induced gene knock out in Drosophila.2014

    • Author(s)
      Kondo T
    • Journal Title

      Development Growth and Differentiation

      Volume: 56:1 Issue: 1 Pages: 86-91

    • DOI

      10.1111/dgd.12097

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22111007, KAKENHI-PROJECT-24657156, KAKENHI-PROJECT-25890014
  • [Journal Article] Targeted mutagenesis in sea urchin embryos using TALENs.2014

    • Author(s)
      Hosoi S, Sakuma T, Sakamoto N and Yamamoto T
    • Journal Title

      Dev Growth Differ

      Volume: 56 Issue: 1 Pages: 92-97

    • DOI

      10.1111/dgd.12099

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24657156, KAKENHI-PROJECT-25890014
  • [Journal Article] Germ cell mutations of the ascidian Ciona intestinalis with TALE nucleases.2014

    • Author(s)
      Yoshida K, Treen N, Hozumi A, Sakuma T, Yamamoto T, Sasakura Y.
    • Journal Title

      Genesis

      Volume: in press Issue: 5 Pages: 431-439

    • DOI

      10.1002/dvg.22770

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21112004, KAKENHI-PROJECT-23681039, KAKENHI-PROJECT-24657156, KAKENHI-PROJECT-25890014
  • [Journal Article] Highly efficient targeted mutagenesis in one-cell mouse embryos mediated by the TALEN and CRISPR/Cas systems2014

    • Author(s)
      A. Yasue, S. N. Mitsui, T. Watanabe, T. Sakuma, S. Oyadomari, T. Yamamoto, S. Noji, T. Mito and E. Tanaka
    • Journal Title

      Sci Rep

      Volume: 4 Issue: 1 Pages: 5705-5705

    • DOI

      10.1038/srep05705

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-ORGANIZER-22124001, KAKENHI-PROJECT-25463184, KAKENHI-PROJECT-25650080, KAKENHI-PROJECT-25890014, KAKENHI-PROJECT-26293436, KAKENHI-PROJECT-26670270, KAKENHI-PROJECT-26870415
  • [Journal Article] Tissue-specific and ubiquitous gene knockouts in Ciona by electroporating TALENs provide new approaches to investigate gene functions2014

    • Author(s)
      Treen, N., Yoshida, K., Sakuma, T., Sasaki, H., Kawai, N., Yamamoto, T., Sasakura, Y.
    • Journal Title

      Development

      Volume: 141 Issue: 2 Pages: 481-487

    • DOI

      10.1242/dev.099572

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21112004, KAKENHI-PROJECT-23681039, KAKENHI-PROJECT-24657156, KAKENHI-PROJECT-25890014
  • [Journal Article] Transcription activator-like effector nucleases efficiently disrupt the target gene in Iberian ribbed newts (Pleurodeles waltl), an experimental model animal for regeneration.2014

    • Author(s)
      Hayashi T, Sakamoto K, Sakuma T, Yokotani N, Inoue T, Kawaguchi E, Agata K, Yamamoto T, Takeuchi T
    • Journal Title

      Development, Growth and Differentiation

      Volume: 56 Issue: 1 Pages: 115-121

    • DOI

      10.1111/dgd.12103

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-ORGANIZER-22124001, KAKENHI-PLANNED-22124002, KAKENHI-PROJECT-24657155, KAKENHI-PROJECT-24657156, KAKENHI-PUBLICLY-25113520, KAKENHI-PUBLICLY-25124706, KAKENHI-PROJECT-25840086, KAKENHI-PROJECT-25890014, KAKENHI-PROJECT-26650082
  • [Journal Article] Human papillomavirus and p53 mutations in head and neck squamous cell carcinoma among Japanese population.2014

    • Author(s)
      Maruyama H, Yasui T, Ishikawa-Fujiwara T, Morii E, Yamamoto Y, Yoshii T, Takenaka Y, Nakahara S, Todo T, Hongyo T, Inohara H.
    • Journal Title

      Cancer Sci.

      Volume: 105(4) Issue: 4 Pages: 409-417

    • DOI

      10.1111/cas.12369

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23241023, KAKENHI-PROJECT-24241018, KAKENHI-PROJECT-24651048, KAKENHI-PROJECT-25220102, KAKENHI-PROJECT-25281019, KAKENHI-PROJECT-25550029
  • [Journal Article] Targeted mutagenesis of multiple and paralogous genes in Xenopus laevis using two pairs of transcription activator-like effector nucleases2014

    • Author(s)
      Sakane, Y., Sakuma, T., Kashiwagi, K., Kashiwagi, A., Yamamoto, T. and Suzuki, K. T.
    • Journal Title

      Dev Growth Differ

      Volume: 56(1) Issue: 1 Pages: 108-114

    • DOI

      10.1111/dgd.12105

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21221004, KAKENHI-ORGANIZER-22124001, KAKENHI-PROJECT-24657156, KAKENHI-PUBLICLY-25124708, KAKENHI-PROJECT-25890014
  • [Journal Article] Microhomology-mediated end-joining-dependent integration of donor DNA in cells and animals using TALENs and CRISPR/Cas92014

    • Author(s)
      S. Nakade, T. Tsubota, Y. Sakane, S. Kume, N. Sakamoto, M. Obara, T. Daimon, H. Sezutsu, T. Yamamoto, T. Sakuma and K. T. Suzuki
    • Journal Title

      Nat Commun

      Volume: 5 Issue: 1 Pages: 5560-5560

    • DOI

      10.1038/ncomms6560

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-ORGANIZER-22124001, KAKENHI-PROJECT-23688008, KAKENHI-PUBLICLY-25124708, KAKENHI-PROJECT-25292202, KAKENHI-PROJECT-25890014, KAKENHI-PROJECT-26290070
  • [Journal Article] TALEN-mediated single-base-pair editing identification of an intergenic mutation upstream of BUB1B as causative of PCS (MVA) syndrome.2014

    • Author(s)
      Ochiai H, Miyamoto T, Kanai A, Hosoba K, Sakuma T, Kudo Y, Asami K, Ogawa A, Watanabe A, Kajii T, Yamamoto T, Matsuura S.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 111(4) Issue: 4 Pages: 1461-6

    • DOI

      10.1073/pnas.1317008111

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23710068, KAKENHI-PROJECT-24310043, KAKENHI-PROJECT-24651222, KAKENHI-PROJECT-24657156, KAKENHI-PUBLICLY-25113521, KAKENHI-PROJECT-25830138, KAKENHI-PROJECT-25890014
  • [Journal Article] Production of Sry knockout mouse using TALEN via oocyte injection.2013

    • Author(s)
      Kato T, Miyata K, Sonobe M, Yamashita S, Tamano M, Miura K, Kanai Y, Miyamoto S, Sakuma T, Yamamoto T, Inui M, Kikusui T, Asahara H, Takada S.
    • Journal Title

      Scientific reports

      Volume: 3 Issue: 1 Pages: 3136-3136

    • DOI

      10.1038/srep03136

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23570265, KAKENHI-PUBLICLY-24115707, KAKENHI-PROJECT-24228005, KAKENHI-PROJECT-24657156, KAKENHI-PLANNED-25118007, KAKENHI-PUBLICLY-25132713, KAKENHI-PROJECT-25890014
  • [Journal Article] Wnt3a stimulates maturation of impaired neutrophils developed from severe congenital neutropenia-derived pluipotent stem cells with heterozygous ELANE mutation.2013

    • Author(s)
      Hiramoto T
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 110 Issue: 8 Pages: 3023-3028

    • DOI

      10.1073/pnas.1217039110

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591161, KAKENHI-PROJECT-23310137, KAKENHI-PROJECT-23650150, KAKENHI-PROJECT-23790126, KAKENHI-PROJECT-24390257, KAKENHI-PROJECT-24390272, KAKENHI-PROJECT-24659489, KAKENHI-PROJECT-25293231, KAKENHI-PLANNED-23106004
  • [Journal Article] Efficient TALEN construction and evaluation methods for human cell and animal applications.2013

    • Author(s)
      Sakuma T, Hosoi S, Woltjen K, Suzuki KI, Kashiwagi K, Wada H, Ochiai H, Miyamoto T, Kawai N, Sasakura Y, Matsuura S, Okada Y, Kawahara A, Hayashi S, Yamamoto T.
    • Journal Title

      Genes to Cells

      Volume: (In press) Issue: 4 Pages: 315-326

    • DOI

      10.1111/gtc.12037

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J02843, KAKENHI-PROJECT-12J06938, KAKENHI-PLANNED-21112004, KAKENHI-PLANNED-22111007, KAKENHI-PROJECT-23710068, KAKENHI-PROJECT-23710240, KAKENHI-PROJECT-24310043, KAKENHI-PROJECT-24651222, KAKENHI-PROJECT-24657156
  • [Journal Article] Repeating pattern of non-RVD variations in DNA-binding modules enhances TALEN activity.2013

    • Author(s)
      Sakuma T, Ochiai H, Kaneko T, Mashimo T, Tokumasu D, Sakane Y, Suzuki K, Miyamoto T, Sakamoto N, Matsuura S, Yamamoto T
    • Journal Title

      Sci Rep.

      Volume: 3 Issue: 1 Pages: 3379-3379

    • DOI

      10.1038/srep03379

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-22124001, KAKENHI-PROJECT-23710068, KAKENHI-PROJECT-24310043, KAKENHI-PROJECT-24651222, KAKENHI-PROJECT-24657156, KAKENHI-PROJECT-24700427, KAKENHI-PUBLICLY-25113521, KAKENHI-PUBLICLY-25124708, KAKENHI-PROJECT-25890014
  • [Journal Article] Efficient gene targeting by TAL effector nucleases coinjected with exonucleases in zygotes2013

    • Author(s)
      Tomoji Mashimo
    • Journal Title

      Scientific Reports

      Volume: 3 Issue: 1 Pages: 1253-1253

    • DOI

      10.1038/srep01253

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12J06938, KAKENHI-PROJECT-21680037, KAKENHI-PROJECT-24310041, KAKENHI-PROJECT-24700427
  • [Journal Article] Nucleosome exclusion from the interspecies conserved central AT-rich region of the Arsinsulater2012

    • Author(s)
      Takagi H, Inai Watanabe SI, Tatemoto S, Yajima M, Akasaka K, Yamamoto T, SakamotoN
    • Journal Title

      J. Biochem

      Volume: 151(1) Pages: 78-87

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21570226
  • [Journal Article] HpSumf1 is involved in the activation of sulafatases responsible for regulation of skeletogenesisduring sea urchin development2011

    • Author(s)
      Sakuma T, Ohnishi K, Fujita K, Ochia H, Sakamoto N, Yamamoto T.
    • Journal Title

      Development Genes and Evolution

      Volume: 221(3) Pages: 157-166

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21570226
  • [Journal Article] Targeted mutagenesis in the sea urchin embryo usingzinc-finger nucleases2010

    • Author(s)
      Ochiai H, Fujita K, Suzuki K, Nishikawa M, Shibata T, Sakamoto N, Yamamoto T.
    • Journal Title

      Genes to Cells

      Volume: 15 Pages: 875-885

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21570226
  • [Journal Article] Dicer is required for the normal development of sea urchin, Hemicentrotus pulcherrimus.2010

    • Author(s)
      Okamitsu Y, Yamamoto T, Fujii, T., Ochiai, H.and Sakamoto, N.
    • Journal Title

      Zoological Science 27(6)

      Pages: 477-486

    • NAID

      40017358605

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20200006
  • [Journal Article] Implication of HpEts in gene regulatory networks responsible for specification of sea urchin skeletogenic primary mesenchyme cells.2010

    • Author(s)
      Yajima M, Umeda R, Fuchikami T, Kataoka M, Sakamoto N, Yamamoto T, Akasaka K.
    • Journal Title

      Zoological Science 27(8)

      Pages: 638-646

    • NAID

      40017358624

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20200006
  • [Journal Article] Mammalian arlysulfatase A functions as a novel component of the extracellular-matrix.2010

    • Author(s)
      Fujita K, Teramura N, Hattori S, Irie S, Mitsunaga-Nakatsubo K, Akimoto T, Sakamoto N, Yamamoto T, Akasaka K.
    • Journal Title

      Connective Tissue Research 51(5)

      Pages: 388-396

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20200006
  • [Journal Article] Targeted mutagenesis in the sea urchin embryo using zinc-finger nucleases.2010

    • Author(s)
      Ochiai H, Fujita K, Suzuki K, Nishikawa M, Shibata T, Sakamoto N, Yamamoto T.
    • Journal Title

      Genes to Cells 15(8)

      Pages: 875-885

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20200006
  • [Journal Article] Mammalian arylsulfatase A functions as a novel component of the extracellular matrix2010

    • Author(s)
      Fujita K, Teramura N, Hattori S, Irie S, Mitsunaga-Nakatsubo K, Akimoto Y, SakamotoN, Yamamoto T, Akasaka K.
    • Journal Title

      Connective Tissue Research

      Volume: 51 Pages: 388-396

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21570226
  • [Journal Article] Implication of HpEts in gene regulatory networks responsible for specification of seaurchin sleletogenic primary me senchyme cells2010

    • Author(s)
      Yajima M, Umeda R, Fuchikami T, Kataoka M, Sakamoto N, Yamamoto T, Akasaka K.
    • Journal Title

      Zoological Science

      Volume: 27 Pages: 638-646

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21570226
  • [Journal Article] Dicer is required for the normalde velopment of sea urchin2010

    • Author(s)
      Okamitsu Y, Yamamoto T, Fujii T, Ochiai H, Sakamoto N
    • Journal Title

      Hemicentrotus pulcherrimus. Zoological Science

      Volume: 27 Pages: 477-486

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21570226
  • [Journal Article] HpSulf, a heparan sulfate 6-O-endosulfatase, is involved in the regulation of VEGF signaling during sea urchin development.2010

    • Author(s)
      Fujita K, Takechi E, Sakamoto N, Sumiyoshi N, Izumi S, Miyamoto T, Matsuura, S, Akasaka K, Yamamoto T.
    • Journal Title

      Mechanisms of Development 127(3-4)

      Pages: 235-245

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20200006
  • [Journal Article] Role of the nanos homolog during sea urchin development.2009

    • Author(s)
      Fujii T, Sakamoto N, Ochiai H, Fujita K, Okamitsu Y, Sumiyoshi N, Minokawa T, Yamamoto T.
    • Journal Title

      Developmental Dynamics 238(10)

      Pages: 2511-2521

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20200006
  • [Journal Article] Suppressor of hairless(Su(H)) is required for foregut development in the sea urchin embryo2009

    • Author(s)
      Karasawa K, Sakamoto N, Fujita K, Ochiai H, Fujii T, Akasaka K, Yamamoto T.
    • Journal Title

      Zoological Science

      Volume: 26 Pages: 686-690

    • NAID

      40016807049

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21570226
  • [Journal Article] Role of the nanos homolog during sea urchin development2009

    • Author(s)
      Fujii T, Sakamoto N, Ochiai H, Fujita K, Okamitsu Y, Sumiyoshi N, Minokawa T, Yamamoto T.
    • Journal Title

      Developmental Dynamics

      Volume: 238 Pages: 2511-2521

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21570226
  • [Journal Article] Suppressor of Hairless (Su(H)) is required for foregut development in the sea urchin embryo.2009

    • Author(s)
      Karasawa K, Sakamoto N, Fujita K, Ochiai H, Fujii T, Akasaka K, Yamamoto T.
    • Journal Title

      Zoological Science 26(10)

      Pages: 686-690

    • NAID

      40016807049

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20200006
  • [Journal Article] HpSulf, a heparin sulfate 6-O-endosulfatase, is involved in the regulation of VEGF signaling during seaurchin development2009

    • Author(s)
      Fujita K, Takechi E, Sakamoto N, SumiyoshiN, Izumi S, Miyamoto T, Matsuura S, Tsurugaya T, Akasaka K, Yamamoto T.
    • Journal Title

      Mechanisms of Development

      Volume: 127 Pages: 235-245

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21570226
  • [Journal Article] Analysis of cis-regulatory elements controlling spatiotemporal expression of T-brain gene in sea urchin2008

    • Author(s)
      Ochiai H, Sakamoto N, Momiyama A, Akasaka K, Yamamoto T.
    • Journal Title

      Hemicentrotus pulcherrimus.Mechanisms of Development 125(1-2)

      Pages: 2-17

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20200006
  • [Journal Article] The Ars insulator facilitates I-SceI meganuclease-mediated transgenesis in the sea urchin embryo.2008

    • Author(s)
      Ochiai H, Sakamoto N, Suzuki K, Akasaka K, Yamamoto T.
    • Journal Title

      Developmental Dynamics 237(9)

      Pages: 2475-2482

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20200006
  • [Journal Article] RSF Governs Silent Chromatin Formation via Histone H2Av Replacement.2008

    • Author(s)
      Hanai K, Furuhashi H, Yamamoto T, Akasaka K, Hirose S
    • Journal Title

      PLoS genetics 4(2)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20200006
  • [Journal Article] DNA variations within the sea urchin Otx enhancer.2007

    • Author(s)
      Yamamoto T.
    • Journal Title

      FEBS letters 581・27

      Pages: 5234-5240

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17570179
  • [Journal Article] DNA variations within the sea urchin Otx enhancer.2007

    • Author(s)
      Yamamoto T., et. al.
    • Journal Title

      FEBS letters 581・27

      Pages: 5234-5240

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17570179
  • [Journal Article] DNA variations within the sea urchin Otx enhancer2007

    • Author(s)
      Yamamoto, T
    • Journal Title

      FEBS Letters 581(27)

      Pages: 5234-5240

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17570179
  • [Journal Article] Sexually dimorphic expression of a teleost homologue of Mulleria inhibiting substance during gonadal sex differentiationin Japanease flounder, Paralichthys olivaceus.2004

    • Author(s)
      Yoshinaga N, Shiraishi E, Yamamoto T, Iguchi Y, Abe SI.
    • Journal Title

      Biochem.Biophys.Res.Commun. 322

      Pages: 508-513

    • Data Source
      KAKENHI-PROJECT-16027235
  • [Journal Article] The Otx binding site is required for the activation of HpOLxL mRNA expression in the sea urchin, Hemlcentrotus pulcherrlmus.2004

    • Author(s)
      Hayashibara Y, Nakatsubo K, Sakamoto N, Shimotori T, Akasaka K, Yamamoto T.
    • Journal Title

      Dev.Growth & Differ. 46

      Pages: 61-67

    • Data Source
      KAKENHI-PROJECT-16027235
  • [Journal Article] A new G-stretch-DNA-binding protein, Unichrom, displays cell-cycle-dependent expression in sea urchin embryos.2004

    • Author(s)
      Moritani K, Tagashira H, Shimotori T, Sakamoto N, Tanaka S, Yamamoto T, Akasaka K
    • Journal Title

      Dev.Growth & Differ. 46

      Pages: 335-341

    • NAID

      10013585223

    • Data Source
      KAKENHI-PROJECT-16027235
  • [Journal Article] Identification of two teleost homologs of the Drosophila sex determination factor, transformer-2 in medaka (Oryzias latipes).2004

    • Author(s)
      Shiraishi E, Imazato H, Yamamoto T, Yokoi H, Abe S, Kitano T.
    • Journal Title

      Mechanisms of Development 121

      Pages: 991-996

    • Data Source
      KAKENHI-PROJECT-16027235
  • [Patent] 標的遺伝子にエフェクタータンパク質を集積するための組成物、およびその利用2018

    • Inventor(s)
      山本卓、佐久間哲史、國井厚志
    • Industrial Property Rights Holder
      山本卓、佐久間哲史、國井厚志
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Data Source
      KAKENHI-PROJECT-17H01409
  • [Patent] 核酸挿入用ベクター2013

    • Inventor(s)
      鈴木賢一、坂根祐人、佐久間哲史、山本卓
    • Industrial Property Rights Holder
      鈴木賢一、坂根祐人、佐久間哲史、山本卓
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-11-06
    • Data Source
      KAKENHI-PROJECT-24657156
  • [Patent] 新規DNA結合ドメインおよびそれを含む新規DNA切断酵素2011

    • Inventor(s)
      山本卓
    • Industrial Property Rights Holder
      山本卓
    • Filing Date
      2011-11-04
    • Data Source
      KAKENHI-PROJECT-21570226
  • [Patent] 新規DNA結合ドメインおよびそれを含む新規DNA切断酵素2011

    • Inventor(s)
      山本卓・坂本尚昭・佐久間哲史・野地澄晴
    • Industrial Property Rights Holder
      広島大学
    • Industrial Property Number
      2011-242250
    • Filing Date
      2011-11-04
    • Data Source
      KAKENHI-PROJECT-21570226
  • [Presentation] 機械受容性カルシウムイオンチャネル・Polycystin-2のコレステロール結合サイトの変異解析2022

    • Author(s)
      森田知佳, 木村相泰, 岸博子, 細羽康介, 伊藤浩史, 山本卓, 宮本達雄
    • Organizer
      日本分子生物学会年会第45回年会
    • Data Source
      KAKENHI-PROJECT-20K21845
  • [Presentation] Peroxisome-mediated cholesterol trafficking into primary cilia2022

    • Author(s)
      宮本達雄, 細羽康介, 山本卓, 斎藤祐見子, 板橋岳志, 岩根敦子
    • Organizer
      第99回日本生理学会大会
    • Data Source
      KAKENHI-PROJECT-20K21845
  • [Presentation] ペルオキシソームを介した繊毛へのコレステロール輸送機構2021

    • Author(s)
      宮本達雄, 細羽康介, 板橋岳志, 岩根敦子, 阿久津シルビア夏子, 落合博, 斎藤裕見子, 山本卓, 松浦伸也
    • Organizer
      第94回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-20K21845
  • [Presentation] ゲノム編集に関する最近の研究動向2021

    • Author(s)
      山本 卓
    • Organizer
      日本薬学会 第141年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H01409
  • [Presentation] 繊毛病としてのペルオキシソーム形成不全症・Zellweger症候群2020

    • Author(s)
      宮本達雄、細羽康介、板橋岳志、岩根敦子、阿久津シルビア夏子、落合博、斎藤裕見子、山本卓、松浦伸也
    • Organizer
      日本人類遺伝学会第65回大会
    • Data Source
      KAKENHI-PROJECT-20K21845
  • [Presentation] Peroxisomes ensure to supply cholesterol into the ciliary membrane : a lesson from a peroxisome-biogenesis disorder Zellweger syndrome2020

    • Author(s)
      Tatsuo Miyamoto, Kosuke Hosoba, Takeshi Itabashi, Atsuko H. Iwane, Silvia Natsuko Akutsu, Hiroshi Ochiai, Yumiko Saito, Takashi Yamamoto, Shinya Matsuura
    • Organizer
      第43回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-20K21845
  • [Presentation] ゲノム編集医療の可能性2020

    • Author(s)
      山本 卓
    • Organizer
      第65回日本生殖医学会学術講演会・総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H01409
  • [Presentation] ゲノム編集技術の最前線2020

    • Author(s)
      山本 卓
    • Organizer
      第7回京都大学-稲盛財団合同「京都賞シンポジウム」
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H01409
  • [Presentation] Applications of Genome Editing Technology for Various Life Science Research2019

    • Author(s)
      Yamamoto T
    • Organizer
      GWG 2019 Genome Engineering Conference
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H01409
  • [Presentation] Basics of genome editing and biased genome editing using the LoAD system in cultured cells and organisms2018

    • Author(s)
      Yamamoto T
    • Organizer
      Functional Genomics and Structural Biology (FGSB)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H01409
  • [Presentation] CRISPR-Cas9の再生医療での可能性2017

    • Author(s)
      山本 卓
    • Organizer
      第2回再生医療産学官連携シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H01409
  • [Presentation] ゲノム編集技術の基本原理 と医学研究での利用2017

    • Author(s)
      山本 卓
    • Organizer
      第16回日本再生医療学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-07
    • Invited
    • Data Source
      KAKENHI-PROJECT-26290070
  • [Presentation] Advances in genome editing technology and its applications in biomedical fields2017

    • Author(s)
      Takashi Yamamoto
    • Organizer
      The 23rd Annual Meeting of Japan Society of Gene and Cell Therapy
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H01409
  • [Presentation] CRISPR-Casシステムを用いたノックインマウス作製における凍結受精卵培養時間の検討2017

    • Author(s)
      中川佳子、佐久間哲史、西道教尚、横崎恭之、竹尾透、山本卓、中潟直己
    • Organizer
      第2回日本ゲノム編集学会
    • Data Source
      KAKENHI-PROJECT-15H04606
  • [Presentation] メダカにおけるrev3l変異体の紫外線誘発突然変異と消化管腫瘍の解析2017

    • Author(s)
      藤川 芳宏、藤原 智子、佐藤 鮎子、佐久間 哲史、山本 卓、辻村 亨、藤堂 剛
    • Organizer
      日本環境変異原学会
    • Data Source
      KAKENHI-PROJECT-25220102
  • [Presentation] CRISPR-Casシステムを用いたノックインマウス作製における凍結受精卵培養時間の検討2017

    • Author(s)
      中川佳子、佐久間哲史、西道教尚、横崎恭之、若松和子、春口幸恵、近藤朋子、竹下由美、中牟田裕子、石田恵理、坂本亘、土山修治、竹尾 透、山本 卓、中潟直己
    • Organizer
      第64回日本実験動物学会
    • Data Source
      KAKENHI-PROJECT-15H04606
  • [Presentation] CRISPR-Casシステムを用いたノックインマウス作製における凍結受精卵培養時間の検討2017

    • Author(s)
      中川佳子、佐久間哲史、西道教尚、横崎泰之、近藤朋子、竹下由美、中牟田裕子、 石田恵理、坂本亘、土山修治、竹尾 透、山本 卓、中潟直己
    • Organizer
      第35回動物生殖工学研究会
    • Data Source
      KAKENHI-PROJECT-15H04606
  • [Presentation] ゲノム編集技術を用いた鎖骨頭蓋異形成症モデルマウスの作成2017

    • Author(s)
      吉本 由紀、森 健吾、星野 麻里、田中 誠真、渡邊 仁美、佐久間 哲史、山下 寛、岡本 哲治、近藤 玄、山本 卓、開 祐司、宿南 知佐
    • Organizer
      日本ゲノム編集学会 第2回大会
    • Data Source
      KAKENHI-PROJECT-16K15780
  • [Presentation] Culture time of zygotes before microinjection affects the production efficiency of CRISPR-Cas9-mediated knock-in mice2017

    • Author(s)
      Yoshiko Nakagawa, Tetsushi Sakuma, Norihisa Nishimichi, Yasuyuki Yokosaki, Toru Takeo, Naomi Nakagata, and Takashi Yamamoto
    • Organizer
      2nd annual Genome Editing & Engineering Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04606
  • [Presentation] ニワトリ始原生殖細胞への効果的なゲノム編集2016

    • Author(s)
      中川祐樹, 江﨑僚, 廣瀬文哉, 古澤修一,佐久間哲史, 黒岩麻里, 山本卓, 堀内浩幸
    • Organizer
      第1回日本ゲノム編集学会
    • Place of Presentation
      広島市
    • Year and Date
      2016-09-06
    • Data Source
      KAKENHI-PROJECT-25292193
  • [Presentation] Rev3L変異体メダカの放射線および紫外線感受性の解析2016

    • Author(s)
      藤川 芳宏、藤原(石川) 智子、佐久間 哲史、山本 卓、藤堂 剛
    • Organizer
      日本放射線影響学会 第59回大会
    • Place of Presentation
      JMSアステールプラザ(広島市)
    • Data Source
      KAKENHI-PROJECT-25220102
  • [Presentation] CRISPR-Casシステムによる遺伝子破壊マウスの作製-超過剰排卵誘起法を用いた凍結受精卵の利用-2016

    • Author(s)
      中川佳子、佐久間哲史、坂本拓弥、山本 卓、若松和子、山下紀代子、春口幸恵、近藤朋子、竹下由美、中牟田裕子、梅野智子、宮川 あい、土山修治、竹尾 透、中潟直己
    • Organizer
      第63回日本実験動物学会
    • Place of Presentation
      ミューザ川崎シンフォニーホール(神奈川県川崎市)
    • Year and Date
      2016-05-18
    • Data Source
      KAKENHI-PROJECT-15H04606
  • [Presentation] CRISPR-Casシステムによる様々なゲノム編集個体の作製―超過剰排卵誘起法を用いた体外受精凍結卵 の利用2016

    • Author(s)
      中川佳子,佐久間哲史,西道教尚,横崎恭之,矢中規之,竹尾 透,中潟直己, 山本 卓
    • Organizer
      第一回ゲノム編集学会
    • Place of Presentation
      広島国際会議場(広島県広島市)
    • Year and Date
      2016-09-06
    • Data Source
      KAKENHI-PROJECT-15H04606
  • [Presentation] ゲノム編集の基本原理と最近の研究動向2016

    • Author(s)
      山本 卓
    • Organizer
      日本学術会議公開学術講演会「ゲノム編集技術の技術と将来展望」
    • Place of Presentation
      東京
    • Year and Date
      2016-08-19
    • Invited
    • Data Source
      KAKENHI-PROJECT-26290070
  • [Presentation] Targeted inactivation of rev3l in medaka (Oryzias latipes)2016

    • Author(s)
      Fujikawa Y,Ishikawa-Fujiwara T,Sakuma T, Yamamoto T, Tsujimura T, Todo T
    • Organizer
      Oryzias latipes 10th 3R International Symposium
    • Place of Presentation
      Hotel Ichibata(松江市)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25220102
  • [Presentation] CRISPR-Casシステムによるfloxマウスの作製-超過剰排卵誘起法を用いた凍結受精卵の利用-2016

    • Author(s)
      中川 佳子、佐久間 哲史、矢中 規之、山本 卓 、若松 和子 、山下 紀代子、春口 幸恵、近藤 朋子、竹下 由美、中牟田 裕子、梅野 智子、土山 修治 、竹尾  透 、中潟 直己
    • Organizer
      第50回日本実験動物技術者協会総会
    • Place of Presentation
      ウェスタ川越(埼玉県川越市)
    • Year and Date
      2016-09-29
    • Data Source
      KAKENHI-PROJECT-15H04606
  • [Presentation] メダカ Rev3L 変異体の紫外線および放射線感受性の解析2016

    • Author(s)
      藤川 芳宏、藤原(石川) 智子、佐久間 哲史、山本 卓、藤堂 剛
    • Organizer
      第38回 光医学・光生物学会
    • Place of Presentation
      京都リサーチパークサイエンスホール(京都市)
    • Data Source
      KAKENHI-PROJECT-25220102
  • [Presentation] ゲノム編集の基本原理と研究動向2016

    • Author(s)
      山本 卓
    • Organizer
      JBAセミナー「ゲノム編集技術の最近の動向と規制・特許について」
    • Place of Presentation
      東京
    • Year and Date
      2016-03-17
    • Invited
    • Data Source
      KAKENHI-PROJECT-26290070
  • [Presentation] ゲノム編集の基本原理と医学分野での利用2016

    • Author(s)
      山本 卓
    • Organizer
      第31回 日本整形外科学会基礎学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2016-10-10
    • Invited
    • Data Source
      KAKENHI-PROJECT-26290070
  • [Presentation] ゲノム編集の基本原理と医学分野での可能性2015

    • Author(s)
      山本 卓
    • Organizer
      日本人類遺伝学会第60回大会
    • Place of Presentation
      東京
    • Year and Date
      2015-10-16
    • Invited
    • Data Source
      KAKENHI-PROJECT-26290070
  • [Presentation] Study on male sex determination gene in the bird using genome editing technology2015

    • Author(s)
      Yuki Nakagawa, Ryo Ezaki, Tetsushi Sakuma, Asato Kuroiwa, Takashi Yamamoto, Hiroyuki Horiuchi
    • Organizer
      Biochemistry and Molecular Biology 2015
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-25292193
  • [Presentation] ゲノム編集が生命科学に革命を起こす2015

    • Author(s)
      山本 卓
    • Organizer
      読売テクノフォーラム
    • Place of Presentation
      東京
    • Year and Date
      2015-06-22
    • Invited
    • Data Source
      KAKENHI-PROJECT-26290070
  • [Presentation] 凍結受精卵を用いたCRISPR/Cas9システムによる遺伝子破壊マウスの作製2015

    • Author(s)
      中川佳子、佐久間哲史、坂本拓弥、大村谷昌樹、山本卓、中潟直己
    • Organizer
      第62回日本実験動物学会総会
    • Place of Presentation
      京都テルサ(京都府京都市)
    • Year and Date
      2015-05-28
    • Data Source
      KAKENHI-PROJECT-15H04606
  • [Presentation] A high efficient gene targeting in one-cell mouse embryos mediated by TALEN and CRISPR/Cas system2014

    • Author(s)
      Akihiro Yasue, Silvia Naomi Mitsui, Takahito Watanabe, Tetsushi Sakuma, Seiichi Oyadomari, Takashi Yamamoto, Sumihare Noji, Taro Mito, Eiji Tanaka
    • Organizer
      International Symposium on RNAi and Genome Editing Research
    • Place of Presentation
      徳島県(徳島大学)
    • Invited
    • Data Source
      KAKENHI-PROJECT-25463184
  • [Presentation] Construction of optimized CRISPR/Cas system to research the anhydrobiosis in the sleeping chironomid2014

    • Author(s)
      Okada J, Kikuta S, Gusev O, Suetugu Y, Cornette R, Yamamoto T, Kikawada T
    • Organizer
      New Frontiers in Anhydrobiosis
    • Place of Presentation
      ポミシェ、フランス
    • Data Source
      KAKENHI-PROJECT-25252060
  • [Presentation] TALエフェクターヌクレアーゼ(TALENs)を用いたノックアウトラット作製技術2013

    • Author(s)
      金子武人、佐久間哲史、山本卓、芹川忠夫、真下知士
    • Organizer
      第60回日本実験動物学会総会
    • Place of Presentation
      つくば国際会議場、茨城県
    • Data Source
      KAKENHI-PROJECT-24700427
  • [Presentation] ラットにおける遺伝子改変技術の新展開2013

    • Author(s)
      芹川忠夫、金子武人、佐久間哲史、山本卓、真下知士
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場、福岡県
    • Data Source
      KAKENHI-PROJECT-24700427
  • [Presentation] ネムリユスリカの乾燥耐性遺伝子検索のためのゲノム編集技術の構築2013

    • Author(s)
      岡田淳, 菊田真吾, Gusev O, 末次克行, Cornette R, 山本卓, 黄川田隆洋
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-25252060
  • [Presentation] TALEN、CRISPR/Cas systemを用いたマウス1細胞期胚における標的遺伝子破壊2013

    • Author(s)
      Akihiro Yasue, Silvia Naomi Mitsui, Takahito Watanabe, Tetsushi Sakuma, Seiichi Oyadomari, Takashi Yamamoto, Sumihare Noji, Taro Mito, Eiji Tanaka
    • Organizer
      日本分子生物学会
    • Place of Presentation
      兵庫県神戸市(神戸国際会議場)
    • Data Source
      KAKENHI-PROJECT-25463184
  • [Presentation] TALエフェクターヌクレアーゼ(TALENs)を用いたノックアウトラット作製技術2013

    • Author(s)
      金子武人、佐久間哲史、山本卓、芹川忠夫、真下知士
    • Organizer
      第60回日本実験動物学会総会
    • Place of Presentation
      つくば国際会議場(つくば市)
    • Data Source
      KAKENHI-PROJECT-24700427
  • [Presentation] 人工ヌクレアーゼを基盤とする動物におけるゲノム編集2012

    • Author(s)
      山本卓
    • Organizer
      日本学術会議公開シンポジウム
    • Place of Presentation
      東京
    • Invited
    • Data Source
      KAKENHI-PROJECT-24657156
  • [Presentation] Targeted insertion of reporter gene by zinc-finger nuclease mediated homologous recombination enables quantitative imaging of endogenous gene expression in living sea urchin embryo2012

    • Author(s)
      Yamamoto T.
    • Organizer
      CDB symposium 2012 Quantitative biology
    • Place of Presentation
      神戸
    • Year and Date
      2012-03-27
    • Data Source
      KAKENHI-PROJECT-21570226
  • [Presentation] 人工ヌクレアーゼを基盤とした培養細胞および動物でのゲノム編集2012

    • Author(s)
      山本卓
    • Organizer
      日本動物学会 第83回大会
    • Place of Presentation
      大阪
    • Invited
    • Data Source
      KAKENHI-PROJECT-24657156
  • [Presentation] Genome editing usingartificial nucleases2012

    • Author(s)
      Yamamoto Takashi
    • Organizer
      The 2^<nd> International Conference on the Cricket
    • Place of Presentation
      徳島
    • Year and Date
      2012-03-22
    • Data Source
      KAKENHI-PROJECT-21570226
  • [Presentation] Efficient gene targeting by TAL effector nucleases coinjected with exonucleases in zygotes.2012

    • Author(s)
      Tomoji Mashimo, Takehito Kaneko, Tetsushi Sakuma, Junya Kobayashi, Yayoi Kunihiro, Birger Voigt, Takashi Yamamoto, Tadao Serikawa
    • Organizer
      Rat Genome and Models
    • Place of Presentation
      ケンブリッジ(イギリス)
    • Data Source
      KAKENHI-PROJECT-24700427
  • [Presentation] Genome editing using artificial nucleases2012

    • Author(s)
      Yamamoto T.
    • Organizer
      The 2^<nd> International Conference on the Cricket
    • Place of Presentation
      徳島
    • Year and Date
      2012-03-22
    • Data Source
      KAKENHI-PROJECT-21570226
  • [Presentation] 人工ヌクレアーゼTALENによるノックアウトラットの作製2012

    • Author(s)
      真下知士、金子武人、国広弥生、佐久間哲史、山本卓、芹川忠夫
    • Organizer
      日本実験動物科学・技術九州2012
    • Place of Presentation
      別府国際コンベンションセンター、大分県
    • Data Source
      KAKENHI-PROJECT-24700427
  • [Presentation] 人工ヌクレアーゼTALENによるノックアウトラットの作製2012

    • Author(s)
      真下知士、金子武人、国広弥生、佐久間哲史、山本卓、芹川忠夫
    • Organizer
      日本実験動物科学・技術 九州2012
    • Place of Presentation
      別府国際コンベンションセンター(大分県)
    • Data Source
      KAKENHI-PROJECT-24700427
  • [Presentation] Efficient gene targeting by TAL effector nucleases in rats2012

    • Author(s)
      Tomoji Mashimo, Takehito Kaneko, Tetsushi Sakuma, Yayoi Kunihiro, Birger Voigt, Takashi Yamamoto, Tadao Serikawa
    • Organizer
      Rat Genome and Models, A Welcome Trust Scientific Conference
    • Place of Presentation
      Cambridge, UK
    • Data Source
      KAKENHI-PROJECT-24700427
  • [Presentation] ラットにおける遺伝子改変技術の新展開2012

    • Author(s)
      芹川 忠夫、金子 武人、佐久間 哲史、山本 卓、真下 知士
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Invited
    • Data Source
      KAKENHI-PROJECT-24700427
  • [Presentation] Efficient gene targeting by TAL effector nucleases in rats2012

    • Author(s)
      Tomoji Mashimo, Takehito Kaneko, Tetsushi Sakuma, Yayoi Kunihiro, Birger Voigt, Takashi Yamamoto, Tadao Serikawa
    • Organizer
      Rat Genome and Models
    • Place of Presentation
      ケンブリッジ(イギリス)
    • Data Source
      KAKENHI-PROJECT-24700427
  • [Presentation] Targeted insertion of reporter gene by zinc-finger nuclease mediated homologous recombination enables quantitative imaging of endogenous gene expression inliving sea urchin embryo2012

    • Author(s)
      Yamamoto Takashi
    • Organizer
      CDB symposium 2012 Quantitative biology
    • Place of Presentation
      神戸
    • Year and Date
      2012-03-27
    • Data Source
      KAKENHI-PROJECT-21570226
  • [Presentation] ZFN法とTALEN法を用いたゲノム編集時代の到来2012

    • Author(s)
      山本卓
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡
    • Invited
    • Data Source
      KAKENHI-PROJECT-24657156
  • [Presentation] 人工ヌクレアーゼ(ZFNやTALEN)を用いたゲノム編集研究の現状と可能性2012

    • Author(s)
      山本卓
    • Organizer
      第5回DNA鑑定学会
    • Place of Presentation
      東京
    • Invited
    • Data Source
      KAKENHI-PROJECT-24657156
  • [Presentation] Efficient gene targeting by TAL effector nucleases coinjected with exonucleases in zygotes2012

    • Author(s)
      Tomoji Mashimo, Takehito Kaneko, Tetsushi Sakuma, Junya Kobayashi, Yayoi Kunihiro, Birger Voigt, Takashi Yamamoto, Tadao Serikawa
    • Organizer
      Techniques and Procedures for Rat Gene Targeting, Reproduction, and Cryopreservation
    • Place of Presentation
      Cambridge, UK
    • Year and Date
      2012-12-03
    • Data Source
      KAKENHI-PROJECT-24700427
  • [Presentation] Targeted gene modification via viaon viaon vian viaation viaiaiaon viaaon viaahomologous end-joining-mediated and homology-directed repairs of ZFN-induced DNA double-stranded breaks2011

    • Author(s)
      Yamamoto Takashi
    • Organizer
      1st international symposium on Genome damage and Non -cancerous diseased
    • Place of Presentation
      Hiroshima.
    • Year and Date
      2011-03-03
    • Data Source
      KAKENHI-PROJECT-20200006
  • [Presentation] 様々な生物での標的遺伝子改変を可能にするゲノム編集技術とその可能性2011

    • Author(s)
      山本卓
    • Organizer
      日本発生生物学会秋季シンポジウム
    • Place of Presentation
      岡崎(招待講演)
    • Year and Date
      2011-12-19
    • Data Source
      KAKENHI-PROJECT-21570226
  • [Presentation] Targeted genemodification via non-homologous end-joining mediatedand homology-directed repairs ofZFN-induced DNA double-stranded breaks2011

    • Author(s)
      Yamamoto Takashi
    • Organizer
      1st international symposium on Genome damageand Non-cancerous diseased
    • Place of Presentation
      Hiroshima
    • Year and Date
      2011-03-03
    • Data Source
      KAKENHI-PROJECT-21570226
  • [Presentation] 様々な生物での標的遺伝子改変を可能にするゲノム編集技術とその可能性2011

    • Author(s)
      山本卓
    • Organizer
      日本発生生物学会秋季シンポジウム
    • Place of Presentation
      岡崎
    • Year and Date
      2011-12-20
    • Data Source
      KAKENHI-PROJECT-21570226
  • [Presentation] 多細胞生物の発生過程における遺伝子発現のゆらぎ2009

    • Author(s)
      山本卓
    • Organizer
      数理生命科学の形成と発展
    • Place of Presentation
      東広島
    • Year and Date
      2009-09-03
    • Data Source
      KAKENHI-PROJECT-21570226
  • [Presentation] 多細胞生物の発生過程における遺伝子発現のゆらぎ2009

    • Author(s)
      山本卓
    • Organizer
      数理生命科学の形成と発展
    • Place of Presentation
      東広島
    • Year and Date
      2009-09-03
    • Data Source
      KAKENHI-PROJECT-20200006
  • [Presentation] 多細胞生物の発生過程における遺伝子発現のゆらぎ2009

    • Author(s)
      山本卓
    • Organizer
      広島大学大学院理学研究科数理分子生命理学専攻シンポジウム・数理生命科学の形成と発展
    • Place of Presentation
      東広島
    • Year and Date
      2009-09-03
    • Data Source
      KAKENHI-PROJECT-21570226
  • [Presentation] 多細胞生物の発生過程における遺伝子発現のゆらぎ2009

    • Author(s)
      山本卓
    • Organizer
      広島大学大学院理学研究科数理分子生命理学専攻シンポジウム・数理生命科学の形成と発展
    • Place of Presentation
      東広島
    • Year and Date
      2009-09-03
    • Data Source
      KAKENHI-PROJECT-20200006
  • [Presentation] Transcriptional regulation of T-brain gene(Tb)during sea urchin(Hemicentrotus pulcherrimus)development2006

    • Author(s)
      Yamamoto, T.
    • Organizer
      20th IUBMB international congress of Biochemistry and Molecular biology
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-06-21
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17570179
  • [Presentation] Transcriptional regulation of T-brain gene (Tb) during sea urchin (Hemicentrotus pulcherrimus) development2006

    • Author(s)
      Yamamoto, T
    • Organizer
      20th IUBMB international congress of biochemistry and molecular biology
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-06-21
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17570179
  • [Presentation] 人工ヌクレアーゼを用いた両生類でのゲノム編集

    • Author(s)
      山本卓
    • Organizer
      日本動物学会第84回大会シンポジウム「生物実験材料としてのネッタイツメガエルの長所と有用性」
    • Place of Presentation
      岡山
    • Invited
    • Data Source
      KAKENHI-PROJECT-24657156
  • [Presentation] ゲノム編集技術を用いた鳥類性決定関連遺伝子の解析

    • Author(s)
      枡岡久子,中川祐樹,江崎僚,佐久間哲史,黒岩麻里,山本卓,堀内浩幸
    • Organizer
      第4回ゲノム編集研究会
    • Place of Presentation
      広島市(広島国際会議場)
    • Year and Date
      2014-10-06 – 2014-10-07
    • Data Source
      KAKENHI-PROJECT-25292193
  • [Presentation] 高活性型TALENの開発と哺乳類培養細胞および動物での標的遺伝子改変

    • Author(s)
      山本卓
    • Organizer
      第65回日本生物工学会シンポジウム「次世代の植物バイオテクノロジー」
    • Place of Presentation
      広島
    • Invited
    • Data Source
      KAKENHI-PROJECT-24657156
  • [Presentation] ゲノム編集革命ー人工ヌクレアーゼを利用した遺伝子改変技術の開発

    • Author(s)
      山本卓
    • Organizer
      平成25年度広島バイオフォーラム「ここまで進んだゲノム科学とその活用」
    • Place of Presentation
      広島
    • Invited
    • Data Source
      KAKENHI-PROJECT-24657156
  • [Presentation] p53-GFPノックインマウス作製の試み

    • Author(s)
      関原和正、佐久間哲史、山本卓、野田朝男
    • Organizer
      日本放射線影響学会第57回大会
    • Place of Presentation
      かごしま県民交流センター(鹿児島市)
    • Year and Date
      2014-10-01 – 2014-10-03
    • Data Source
      KAKENHI-PROJECT-25220102
  • [Presentation] Genome editing using Platinum TALENs

    • Author(s)
      Sakuma T, Suzuki KI and Yamamoto T
    • Organizer
      FASEB Science Research Conference
    • Place of Presentation
      Nassau, Bahamas
    • Year and Date
      2014-06-22 – 2014-06-27
    • Data Source
      KAKENHI-PROJECT-24657156
  • [Presentation] 人工多能性幹細胞における X 線に対する高感受性細胞死のp53依存的な誘導機構の解明

    • Author(s)
      香川 晴信,河合 秀彦,佐久間 哲史,山本 卓,塩谷 文章,嶋本 顕,田原 栄俊
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸国際会議場
    • Data Source
      KAKENHI-PROJECT-25670030
  • [Presentation] Highly efficient targeted mutagenesis in one-cell mouse embryos mediated by TALEN and CRISPR/Cas systems.

    • Author(s)
      Yasue A, Mitsui SN, Watanabe T, Sakuma T, Oyadomari S, Yamamoto T, Noji S, Mito T, Tanaka E
    • Organizer
      The X meeting for Spanish Society for Developmental Biology (SEBD)
    • Place of Presentation
      Madrid (Spain)
    • Year and Date
      2014-10-13 – 2014-10-15
    • Data Source
      KAKENHI-PROJECT-25463184
  • [Presentation] Platinum TALENの開発と様々な動物におけるゲノム編集

    • Author(s)
      山本卓
    • Organizer
      理研シンポジウム「ゲノムデザイン技術と疾患モデル研究」
    • Place of Presentation
      つくば
    • Invited
    • Data Source
      KAKENHI-PROJECT-24657156
  • [Presentation] ネムリユスリカの乾燥耐性遺伝子検索のためのゲノム編集技術の構築

    • Author(s)
      岡田淳, 菊田真吾, Gusev O, 末次克行, Cornette R, 山本卓, 黄川田隆洋
    • Organizer
      第59回低温生物工学会年会セミナー及び年会
    • Place of Presentation
      九州大学
    • Year and Date
      2014-06-28 – 2014-06-29
    • Data Source
      KAKENHI-PROJECT-25252060
  • [Presentation] CRISPR/CasシステムによるPax6遺伝子破壊マウスの解析

    • Author(s)
      河野仁美、泰江章博、石丸善康、井上順治、渡辺崇仁、板東哲哉、親泊政一、野地澄晴、三戸太郎、山本卓、田中栄二、大内淑代
    • Organizer
      第37回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2014-11-25 – 2014-11-27
    • Data Source
      KAKENHI-PROJECT-25463184
  • [Presentation] Genome editing in cultured cells and animals using TALENs and CRISPR/Cas

    • Author(s)
      Yamamoto T
    • Organizer
      The 3rd “International Institute for Advanced Studies” Conference of Novel Developments on the Study of Life and Biological Systems Based on Genome Engineering and Imaging Science
    • Place of Presentation
      木津川市
    • Year and Date
      2014-10-28 – 2014-10-29
    • Invited
    • Data Source
      KAKENHI-PROJECT-26290070
  • [Presentation] MMEJ-mediated integration of donor DNA in cells and animals using TALENs and CRISPR/Cas9

    • Author(s)
      Nakade S, Tsubota T, Sakane Y, Kume S, Sakamoto N, Obara M, Daimon T, Sezutsu H, Yamamoto T, Sakuma T and Suzuki KI
    • Organizer
      Keystone Sympsia
    • Place of Presentation
      Big Sky, MT, USA
    • Year and Date
      2015-01-11 – 2015-01-16
    • Data Source
      KAKENHI-PROJECT-26290070
  • [Presentation] ゲノム編集技術の限りない可能性

    • Author(s)
      山本卓
    • Organizer
      染色体工学研究センター研究成果発表会
    • Place of Presentation
      東京
    • Invited
    • Data Source
      KAKENHI-PROJECT-24657156
  • [Presentation] TALENsによるメダカにおけるTLSポリメラーゼ遺伝子群変異体の網羅的作製

    • Author(s)
      藤川芳宏、藤原(石川) 智子、佐久間哲史、山本 卓、藤堂 剛
    • Organizer
      日本放射線影響学会第57回大会
    • Place of Presentation
      かごしま県民交流センター(鹿児島市)
    • Year and Date
      2014-10-01 – 2014-10-03
    • Data Source
      KAKENHI-PROJECT-25220102
  • [Presentation] ゲノム編集技術による乾燥耐性遺伝子検索のためのツール構築

    • Author(s)
      岡田淳, 菊田真吾, Gusev O, 末次克行, Cornette R, 山本卓, 黄川田隆洋
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Data Source
      KAKENHI-PROJECT-25252060
  • 1.  ABE Shinich (90109637)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 0 results
  • 2.  TAKAMUNE Kazufumi (20206882)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 3.  SHIBATA Tatsuo (10359888)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 2 results
  • 4.  SAKAKMOTO Naoaki (00332338)
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  • 55.  OHARA osamu
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  • 56.  ASANO takaki
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  • 60.  TAKADA Shuji
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  • 70.  阿形 清和
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  • 71.  KNUT Woltjen
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