KOBAYASHI Hiroya 小林博也

Researcher Number	90280867
Other IDs
External Links
Affiliation (Current)	2025: 旭川医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2011 – 2025: 旭川医科大学, 医学部, 教授 2009 – 2010: Asahikawa Medical College, 医学部, 講師 2007 – 2008: Asahikawa Medical College, Pathology, assistant professor 2002 – 2006: 旭川医科大学, 医学部, 助手 1997 – 1999: 旭川医科大学, 医学部, 助手 1998: 旭川医大, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 49020:Human pathology-related / Experimental pathology / Human pathology / Experimental pathology Except Principal Investigator Basic Section 56050:Otorhinolaryngology-related / Otorhinolaryngology / Basic Section 49020:Human pathology-related / Experimental pathology / Experimental pathology
Keywords	Principal Investigator 腫瘍免疫 / HLA / ペプチド / ヘルパーT細胞 / 免疫治療 / エピトープ / T cell / STEAP / ワクチン / 複合癌免疫療法 … More / 免疫抑制性腫瘍微小環境 / cGAS/STING/I型IFN / 癌免疫微小環境 / STING / cGAMP / I型インターフェロン / ビメンチN / 大腸癌 / EMT / リン酸化 / ビメンチン / T-cell / グリオーマ / 免疫監視機構 / 免疫逃避機構 / cancer vaccines / Immunotherapy / Tumor / Helper T lymphocyte / Epitope / Peptide / EBV / Tax / HTLV-1 / 腫瘍 / EBウイルス / CD4ヘルパーT細胞 / 癌抗原 / FAK / Aurora-A / 腫瘍抗原 / CD4 ヘルパーT 細胞 / WT1 / 癌ワクチン / 免疫療法 / 前立腺癌 / neu / HER2 … More Except Principal Investigator 鼻性NK/T細胞リンパ腫 / 腫瘍免疫 / LMP1 / EBウイルス / ワクチン / ペプチド / 頭頸部癌 / 免疫療法 / 免疫チェックポイント / NK/T細胞リンパ腫 / promiscuous epitope / EBV DNA / IP-10 / LMP2 / IL-9 / 悪性腫瘍 / 頭頸部外科学 / Epstein-Barr virus / T細胞リンパ腫 / 鼻性NK / 単球由来樹状細胞 / がん所属リンパ節 / バイオマーカー / 免疫抑制 / 腫瘍抗原 / ペプチドワクチン / がん / 感染症 / 抗原特異的T細胞 / 抗原提示能 / サイトカイン産生 / 神経ペプチド受容体 / 神経ペプチド / 樹状細胞 / 頭頸部外科 / intra-arterial chemotherapy / T cell lymphoma / nasal NK / 動注化学療法 / NKレセプター / EBV DNA量 / CXCR3 / ケモカイン / 浅側頭動脈動注化学療法 / Allele-specific binding motif / Disease susceptibility / HLA-binding peptides / HLA molecules / 疾患感受性 / アリル特異的結合モチーフ / 疾病感受性 / HLA分子結合ペプチド / HLA分子 / 悪性リンパ腫 / miR-15a / CCR4 / chemokine / CD70 / IFN gamma-inducible protein-10 (IP-10) / メタロエラスターゼ / LFA-1 / 単球 / TARC / IFN gamma-inducible protein-10(IP-10) / EBウイルス膜蛋白 / 浅側頭動脈動注・放射線同時併用療法 / monocytes / IP-10 (Interferon gamma-induced protein-10) / LMP1(latent membrane protein 1) Less

免疫抑制性腫瘍微小環境の打破に関わる基盤的複合癌免疫療法の開発研究Principal Investigator
- Principal Investigator
  
  小林博也
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Asahikawa Medical College
がん免疫治療の奏効率向上を目指した腫瘍微小環境内の良質な炎症状態の誘導戦略
- Principal Investigator
  
  大栗敬幸
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Asahikawa Medical College
頭頸部癌特異的T細胞を活用した複合型免疫療法の開発
- Principal Investigator
  
  熊井琢美
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Asahikawa Medical College
cGAS/STING/I型IFN経路を基軸とした癌免疫微小環境のホット化治療戦略Principal Investigator
- Principal Investigator
  
  小林博也
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Asahikawa Medical College
Establishment of novel immunotherapy against nasal NK/T cell lymphoma
- Principal Investigator
  
  Harabuchi Yasuaki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Asahikawa Medical College
Biomarkers to select the immune checkpoint inhibitor-responder in head and neck cancer
- Principal Investigator
  
  Kumai Takumi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Asahikawa Medical College
癌特異的翻訳後修飾を受けたビメンチンを標的とした頭頸部扁平上皮癌の免疫治療
- Principal Investigator
  
  大原賢三
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Asahikawa Medical College
Epithelial mesenchymal transition (EMT)-associated proteins as potent immunotherapeutic target for canner immunotherapyPrincipal Investigator
- Principal Investigator
  
  Kobayashi Hiroya
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Asahikawa Medical College
Developing novel immunotherapy against nasal NK/T cell lymphoma
- Principal Investigator
  
  Harabuchi Yasuaki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Asahikawa Medical College
Analysis of stealth antigens for developing tumor immunotherapyPrincipal Investigator
- Principal Investigator
  
  Kobayashi Hiroya
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Human pathology
- Research Institution
  Asahikawa Medical College
Development of novel diagnosis and therapeutic procedures for nasal NK/T-cell lymphoma consists of targeting EBV-associated molecules
- Principal Investigator
  
  Harabuchi Yasuaki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Asahikawa Medical College
Studies of neuropeptide signaling on functional regulation of dendritic cells and the pathogenesis of cancer and inflammatory diseases
- Principal Investigator
  
  Kitamura Hidemitsu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Hokkaido University
Assessment of T-cell based immunotherapy targeting EGFR with immune-molecular targeted combination therapy for treatment of reflactory cancer.Principal Investigator
- Principal Investigator
  
  KOBAYASHI Hiroya
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Asahikawa Medical College
A foundational study for targeted therapy against EB virus and tumor growth factor in nasal NK/T-cell lymphoma
- Principal Investigator
  
  HARABUCHI Yasuaki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Asahikawa Medical College
Developing T-cell based immunotherapy using ubiquitously expressing tumor-associated antigen, Aurora-A kinase and FAKPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Hiroya
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Asahikawa Medical College
Fundamental investigation aimed at EB virus-targeted therapy for nasal NK/T-cell lymphoma.
- Principal Investigator
  
  HARABUCHI Yasuaki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Asahikawa Medical College
Identification of T-helper peptide-epitopes against gene product of Epstein-Barr virus and Hunan T-cell leukemia virus type I.Principal Investigator
- Principal Investigator
  
  KOBAYASHI Hiroya
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Asahikawa Medical College
Development of New diagnostic methods and treatments against EB virus as a target in nasal NK/T cell lymphoma
- Principal Investigator
  
  HARABUCHI Yasuaki
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Asahikawa Medical College
難治性前立腺癌に対する細胞免疫治療に必要なヘルパーT細胞エピトープペプチドの同定Principal Investigator
- Principal Investigator
  
  小林博也
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Asahikawa Medical College
有効な腫瘍拒絶反応を惹起しうるHER2/neuヘルパーT細胞エピトープの同定Principal Investigator
- Principal Investigator
  
  小林博也
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Asahikawa Medical College
重症筋無力症発症に関わるアセチルコリンリセプター責任抗原ペプチドの同定Principal Investigator
- Principal Investigator
  
  小林博也
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Experimental pathology
- Research Institution
  Asahikawa Medical College
Regulation mechanisms of the development of HLA-linked diseases by the complexes of HLA molecules and peptides.
- Principal Investigator
  
  KATAGIRI Makoto
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  ASAHIKAWA MEDICAL COLLEGE

[Journal Article] Soluble CD27 as a predictive biomarker for intra-tumoral CD70/CD27 interaction in nasopharyngeal carcinoma2024
- Author(s)
  Nagato T, Komatsuda H, Hayashi R, Takahara M, Ujiie N, Kosaka A, Ohkuri T, Oikawa K, Sato R, Wakisaka R, Kono M, Yamaki H, Ohara K, Kumai T, Kishibe K, Katada A, Hayashi T, Kobayashi H
- Journal Title
  
  Cancer Science
  
  Volume: 115 Issue: 4 Pages: 1073-1084
- DOI
  10.1111/cas.16079
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09599, KAKENHI-PROJECT-21H03082
[Journal Article] Immunotherapy targeting tumor‐associated antigen in a mouse model of head and neck cancer2024
- Author(s)
  Kono Michihisa、Wakisaka Risa、Komatsuda Hiroki、Hayashi Ryusuke、Kumai Takumi、Yamaki Hidekiyo、Sato Ryosuke、Nagato Toshihiro、Ohkuri Takayuki、Kosaka Akemi、Ohara Kenzo、Kishibe Kan、Kobayashi Hiroya、Hayashi Tatsuya、Takahara Miki
- Journal Title
  
  Head and Neck
  
  Volume: - Issue: 8 Pages: 2056-2067
- DOI
  10.1002/hed.27703
- Data Source
  KAKENHI-PROJECT-23K08977
[Journal Article] Expression of soluble CD27 in extranodal natural killer/T-cell lymphoma, nasal type: potential as a biomarker for diagnosis and CD27/CD70-targeted therapy2023
- Author(s)
  Nagato T, Komatsuda H, Hayashi R, Takahara M, Kishibe K, Yasuda S, Yajima Y, Kosaka A, Ohkuri T, Oikawa K, Harabuchi S, Kono M, Yamaki H, Wakisaka R, Hirata-Nozaki Y, Ohara K, Kumai T, Katada A, Hayashi T, Harabuchi Y, Kobayashi H
- Journal Title
  
  Cancer Immunology, Immunotherapy
  
  Volume: 72 Issue: 7 Pages: 2087-2098
- DOI
  10.1007/s00262-023-03394-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09599, KAKENHI-PROJECT-21H03082
[Journal Article] Brachyury-targeted immunotherapy combined with gemcitabine against head and neck cancer2023
- Author(s)
  Yamaki Hidekiyo、Kono Michihisa、Wakisaka Risa、Komatsuda Hiroki、Kumai Takumi、Hayashi Ryusuke、Sato Ryosuke、Nagato Toshihiro、Ohkuri Takayuki、Kosaka Akemi、Ohara Kenzo、Kishibe Kan、Takahara Miki、Hayashi Tatsuya、Kobayashi Hiroya、Katada Akihiro
- Journal Title
  
  Cancer Immunology, Immunotherapy
  
  Volume: 72 Issue: 8 Pages: 2799-2812
- DOI
  10.1007/s00262-023-03460-0
- Data Source
  KAKENHI-PROJECT-23K08977
[Journal Article] Mitogen‐activated protein kinase inhibition augments the T cell response against HOXB7‐expressing tumor through human leukocyte antigen upregulation2022
- Author(s)
  Komatsuda Hiroki、Wakisaka Risa、Kono Michihisa、Kumai Takumi、Hayashi Ryusuke、Yamaki Hidekiyo、Sato Ryosuke、Nagato Toshihiro、Ohkuri Takayuki、Kosaka Akemi、Ohara Kenzo、Takahara Miki、Katada Akihiro、Kobayashi Hiroya
- Journal Title
  
  Cancer Science
  
  Volume: 114 Issue: 2 Pages: 399-409
- DOI
  10.1111/cas.15619
- Data Source
  KAKENHI-PROJECT-21H03082, KAKENHI-PROJECT-20K09724
[Journal Article] Immunomodulation via FGFR inhibition augments FGFR1 targeting T-cell based antitumor immunotherapy for head and neck squamous cell carcinoma2022
- Author(s)
  Kono Michihisa、Komatsuda Hiroki、Yamaki Hidekiyo、Kumai Takumi、Hayashi Ryusuke、Wakisaka Risa、Nagato Toshihiro、Ohkuri Takayuki、Kosaka Akemi、Ohara Kenzo、Kishibe Kan、Takahara Miki、Katada Akihiro、Hayashi Tatsuya、Kobayashi Hiroya、Harabuchi Yasuaki
- Journal Title
  
  OncoImmunology
  
  Volume: 11 Issue: 1
- DOI
  10.1080/2162402x.2021.2021619
- Data Source
  KAKENHI-PROJECT-20K09724
[Journal Article] A critical role of STING-triggered tumor-migrating neutrophils for anti-tumor effect of intratumoral cGAMP treatment2021
- Author(s)
  Nagata Marino、Kosaka Akemi、Yajima Yuki、Yasuda Syunsuke、Ohara Mizuho、Ohara Kenzo、Harabuchi Shohei、Hayashi Ryusuke、Funakoshi Hiroshi、Ueda Jun、Kumai Takumi、Nagato Toshihiro、Oikawa Kensuke、Harabuchi Yasuaki、Esteban Celis、Ohkuri Takayuki、Kobayashi Hiroya
- Journal Title
  
  Cancer Immunology, Immunotherapy
  
  Volume: epub Issue: 8 Pages: 2301-2312
- DOI
  10.1007/s00262-021-02864-0
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02948, KAKENHI-PROJECT-19K06452
[Journal Article] Interruption of MDM2 signaling augments MDM2-targeted T cell-based antitumor immunotherapy through antigen-presenting machinery2021
- Author(s)
  Kono Michihisa、Kumai Takumi、Hayashi Ryusuke、Yamaki Hidekiyo、Komatsuda Hiroki、Wakisaka Risa、Nagato Toshihiro、Ohkuri Takayuki、Kosaka Akemi、Ohara Kenzo、Kishibe Kan、Takahara Miki、Katada Akihiro、Hayashi Tatsuya、Celis Esteban、Kobayashi Hiroya、Harabuchi Yasuaki
- Journal Title
  
  Cancer Immunology, Immunotherapy
  
  Volume: epub Issue: 12 Pages: 3421-3434
- DOI
  10.1007/s00262-021-02940-5
- Data Source
  KAKENHI-PROJECT-18H02948
[Journal Article] Expression of placenta-specific 1 and its potential for eliciting anti-tumor helper T-cell responses in head and neck squamous cell carcinoma2020
- Author(s)
  Hayashi Ryusuke、Nagato Toshihiro、Kumai Takumi、Ohara Kenzo、Ohara Mizuho、Ohkuri Takayuki、Hirata-Nozaki Yui、Kosaka Akemi、Yasuda Syunsuke、Oikawa Kensuke、Kono Michihisa、Kishibe Kan、Takahara Miki、Katada Akihiro、Hayashi Tatsuya、Celis Esteban、Harabuchi Yasuaki、Kobayashi Hiroya et al
- Journal Title
  
  OncoImmunology
  
  Volume: 10 Issue: 1 Pages: 1856545-1856545
- DOI
  10.1080/2162402x.2020.1856545
- Data Source
  KAKENHI-PROJECT-18H02948
[Journal Article] Phosphorylated vimentin as an immunotherapeutic target against metastatic colorectal cancer.2019
- Author(s)
  Ohara M, Ohara K, Kumai T, Ohkuri T, Nagato T, Hirata-Nozaki Y, Kosaka A, Nagata M, Hayashi R, Harabuchi S, Yajima Y, Oikawa K, Harabuchi Y, Sumi Y, Furukawa H, Kobayashi H.
- Journal Title
  
  Cancer Immunol Immunother.
  
  Volume: ePub Issue: 6 Pages: 989-999
- DOI
  10.1007/s00262-020-02524-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02948, KAKENHI-PROJECT-19K07452
[Journal Article] PD-L1-specific helper T-cells exhibit effective antitumor responses: new strategy of cancer immunotherapy targeting PD-L1 in head and neck squamous cell carcinoma.2019
- Author(s)
  Hirata-Nozaki Y, Ohkuri T, Ohara K, Kumai T, Nagata M, Harabuchi S, Kosaka A, Nagato T, Ishibashi K, Oikawa K, Aoki N, Ohara M, Harabuchi Y, Uno Y, Takei H, Celis E, Kobayashi H.
- Journal Title
  
  J Transl Med.
  
  Volume: 17 Issue: 1
- DOI
  10.1186/s12967-019-1957-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02948
[Journal Article] Intratumoral STING activations overcome negative impact of cisplatin on antitumor immunity by inflaming tumor microenvironment in squamous cell carcinoma.2019
- Author(s)
  Harabuchi S, Kosaka A, Yajima Y, Nagata M, Hayashi R, Kumai T, Ohara K, Nagato T, Oikawa K, Ohara M, Harabuchi Y, Ohkuri T, Kobayashi H.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 522 Issue: 2 Pages: 408-414
- DOI
  10.1016/j.bbrc.2019.11.107
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02948, KAKENHI-PROJECT-19K18791
[Journal Article] Cyclin-dependent kinase 1 and survivin as potential therapeutic targets against nasal natural killer/T-cell lymphoma2019
- Author(s)
  Nagato Toshihiro、Ueda Seigo、Takahara Miki、Kishibe Kan、Komabayashi Yuki、Kumai Takumi、Ohara Kenzo、Hirata-Nozaki Yui、Harabuchi Shohei、Hayashi Ryusuke、Ohkuri Takayuki、Bernasconi Michele、Nadal David、Kobayashi Hiroya、Harabuchi Yasuaki
- Journal Title
  
  Laboratory Investigation
  
  Volume: 99 Issue: 5 Pages: 612-624
- DOI
  10.1038/s41374-018-0182-9
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02948
[Journal Article] 鼻性NK/T細胞リンパ腫に対する革新的免疫療法の開発2018
- Author(s)
  長門利純、熊井琢美,、高原幹、大栗敬幸、小林博也、Celis Esteban、原渕保明
- Journal Title
  
  耳鼻咽喉科免疫アレルギー
  
  Volume: 36 Pages: 15-22
- NAID
  130006619256
- Data Source
  KAKENHI-PROJECT-18H02948
[Journal Article] Programmed death-ligand 1 and its soluble form are highly expressed in nasal natural killer/T-cell lymphoma: a potential rationale for immunotherapy2017
- Author(s)
  Toshihiro Nagato, Takayuki Ohkuri, Kenzo Ohara, Yui Hirata, Kan Kishibe, Yuki Komabayashi, Seigo Ueda, Miki Takahara, Takumi Kumai, Kei Ishibashi, Akemi Kosaka, Naoko Aoki, Kensuke Oikawa, Yuji Uno, Naoko Akiyama, Masatoshi Sado, Hidehiro Takei, Esteban Celis, Yasuaki Harabuchi, Hiroya Kobayashi
- Journal Title
  
  Cancer Immunol Immunother
  
  Volume: 印刷中 Issue: 7 Pages: 877-890
- DOI
  10.1007/s00262-017-1987-x
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462576, KAKENHI-PROJECT-15K20172, KAKENHI-PROJECT-15K20174, KAKENHI-PROJECT-15H04986
[Journal Article] Assessment of the change in cetuximab-induced antibody-dependent cellular cytotoxicity activity of natural killer cells by steroid.2016
- Author(s)
  Kumai T, Oikawa K, Aoki N, Kimura S, Harabuchi Y, Kobayashi H.
- Journal Title
  
  Head Neck.
  
  Volume: 38(3) Issue: 3 Pages: 410-6
- DOI
  10.1002/hed.23906
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460430, KAKENHI-PROJECT-24791735
[Journal Article] Targeting HER-3 to elicit antitumor helper T cells against head and neck squamous cell carcinoma.2015
- Author(s)
  Kumai T, Ohkuri T, Nagato T, Matsuda Y, Oikawa K, Aoki N, Kimura S, Celis E, Harabuchi Y, Kobayashi H.
- Journal Title
  
  Scientific Reports
  
  Volume: 5 Issue: 1 Pages: 16280-16280
- DOI
  10.1038/srep16280
- NAID
  120005690964
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460430, KAKENHI-PROJECT-24791735
[Journal Article] c-Met is a novel tumor associated antigen for T-cell based immunotherapy against NK/T cell lymphoma.2015
- Author(s)
  Kumai T, Matsuda Y, Ohkuri T, Oikawa K, Ishibashi K, Aoki N, Kimura S, Harabuchi Y, Celis E, Kobayashi H.
- Journal Title
  
  Oncoimmunology
  
  Volume: 4(2)
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460430
[Journal Article] Neuropeptide signaling through neurokinin-1 and 2 receptors augments antigen presentation by human dendritic cells.2015
- Author(s)
  Junya Ohtake, Shun Kaneumi, Mishie Tanino, Takuto Kishikawa, Satoshi Terada, Kentaro Sumida, Kazutaka Masuko, Yosuke Ohno, Toshiyuki Kita, Sadahiro Iwabuchi, Toshiya Shinohara, Yoshinori Tanino, Tamiko Takemura, Shinya Tanaka, Hiroya Kobayashi, and Hidemitsu Kitamura.
- Journal Title
  
  Journal of Allergy and Clinical Immunology.
  
  Volume: 136 Issue: 6 Pages: 1690-1694
- DOI
  10.1016/j.jaci.2015.06.050
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08359, KAKENHI-PROJECT-15K08416
[Journal Article] Novel targets for natural killer/T-cell lymphoma immunotherapy2015
- Author(s)
  Takumi Kumai
- Journal Title
  
  Immunotherapy
  
  Volume: 8 Issue: 1 Pages: 45-55
- DOI
  10.2217/imt.15.103
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04986, KAKENHI-PROJECT-25460430, KAKENHI-PROJECT-24791735
[Journal Article] CCL17 and CCL22/CCR4 signaling is a strong candidate for novel targeted therapy against nasal natural killer/T-cell lymphoma2015
- Author(s)
  Takumi Kumai, Toshihiro Nagato, Hiroya Kobayashi, Yuki Komabayashi, Seigo Ueda, Kan Kishibe, Takayuki Ohkuri, Miki Takahara, Esteban Celis, Yasuaki Harabuchi
- Journal Title
  
  Cancer Immunology, Immunotherapy
  
  Volume: - Issue: 6 Pages: 697-705
- DOI
  10.1007/s00262-015-1675-7
- NAID
  120005774022
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390385, KAKENHI-PROJECT-15H04986
[Journal Article] Induction of tumor-reactive T helper responses by a posttranslational modified epitope from tumor protein p53.2014
- Author(s)
  Kumai T, Ishibashi K, Oikawa K, Matsuda Y, Aoki N, Kimura S, Hayashi S, Kitada M, Harabuchi Y, Celis E, Kobayashi H.
- Journal Title
  
  Cancer Immunol Immunother
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460430
[Journal Article] Tumor-derived TGF-β and prostaglandin E2 attenuate anti-tumor immune responses in head and neck squamous cell carcinoma treated with EGFR inhibitor.2014
- Author(s)
  Kumai T, Oikawa K, Aoki N, Kimura S, Harabuchi Y, Celis E, Kobayashi H.
- Journal Title
  
  J Transl Med.
  
  Volume: 12 Issue: 1 Pages: 265-265
- DOI
  10.1186/s12967-014-0265-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460430
[Journal Article] EGFR inhibitors augment antitumour helper T-cell responses of HER family-specific immunotherapy2013
- Author(s)
  T Kumai, Y Matsuda, K Oikawa, N Aoki, S Kimura, Y Harabuchi, E Celis and H Kobayashi
- Journal Title
  
  BRITISH JOURNAL OF CANCER
  
  Volume: 577 Issue: 8 Pages: 1-12
- DOI
  10.1038/bjc.2013.577
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791735, KAKENHI-PROJECT-25460430
[Journal Article] Six-transmembrane epithelial antigen of the prostate and enhancer of zeste homolog 2 asimmunotherapeutic targets for lung cancer2011
- Author(s)
  Hayashi S, Kumai T, Matsuda Y, Aoki N, SatoK, Kimura S, Kitada M, Tateno M, Celis E, Kobayashi H.
- Journal Title
  
  J Transl Med
  
  Volume: 9 Issue: 1 Pages: 191-191
- DOI
  10.1186/1479-5876-9-191
- Data Source
  KAKENHI-PROJECT-21590424
[Journal Article] Characterization of human CD4 helper T cell responses against Aurora-A kinase A2010
- Author(s)
  Hiroya Kobayashi
- Journal Title
  
  Cancer Immunol Immunother
  
  Volume: 59 Pages: 1029-1039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590424
[Journal Article] Characterization of human CD4 helper T cell responses against Aurora kinase A2010
- Author(s)
  Kobayashi H
- Journal Title
  
  Cancer Immunol Immunother
  
  Volume: 59 Pages: 1029-1039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390438
[Journal Article] Characterization of human CD4 helper T cellresponses against Aurora kinase A2010
- Author(s)
  Kobayashi H, Azumi M, Hayashi S, Sato K, Aoki N, Kimura S, Kakizaki H, NagatoT, Harabuchi Y, Tateno M, Celis E
- Journal Title
  
  CancerImmunol Immunother
  
  Volume: 59(7) Issue: 7 Pages: 1029-39
- DOI
  10.1007/s00262-010-0826-0
- Data Source
  KAKENHI-PROJECT-21590424
[Journal Article] Focal adhesion kinase as animmunother apeutic target.2009
- Author(s)
  Kobayashi H, Azumi M, Kimura Y, Sato K, Aoki N, Kimura S, Honma M, Iizuka H, Tateno M, Celis E.
- Journal Title
  
  Cancer Immunol Immunother
  
  Volume: 58(6) Issue: 6 Pages: 931-40
- DOI
  10.1007/s00262-008-0608-0
- Data Source
  KAKENHI-PROJECT-21590424
[Journal Article] Focal adhesion kinase as an immunotherapeutic target2009
- Author(s)
  Hiroya Kobayashi
- Journal Title
  
  Cancer Immunology Immunotherapy 58
  
  Pages: 931-940
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590424
[Journal Article] Induction of EBV-latent membrane protein 1-specific MHC class II-restricted T-cell responses against natural killer lymphoma cells.2008
- Author(s)
  Kobayashi, H., Nagato, T., Takahara, M., Sato, K., Kimura, S., Aoki, N., Azumi, M., Tateno, M., Harabuchi, Y. and Celis, E.
- Journal Title
  
  Cancer Res. 68
  
  Pages: 901-908
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590360
[Journal Article] romiscuous peptides on the nontypeable Haemophilus influenzae P6 outer membrane protein2008
- Author(s)
  Nomura Y, Abe Y, Ishida Y, Kobayashi H, Harabuchi Y.
- Journal Title
  
  J Clin Immunol 28
  
  Pages: 361-369
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390438
[Journal Article] Induction of EBV-latent membrane protein 1-specific MHC class ll-restricted T-cell responses against natural killer lymphoma cells2008
- Author(s)
  Hiroya, Kobayashi.
- Journal Title
  
  Cancer Research 68
  
  Pages: 901-908
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590360
[Journal Article] Induction of EBV-latent membrane protein 1-specific MHC class II-restricted T-cell responses against natural killer lymphoma cells.2008
- Author(s)
  Kobayashi H, Nagato T, Takahara M, Sato K, Kimura S, Aoki N, Azumi M, Tateno M, Harabuchi Y, Celis E
- Journal Title
  
  Cancer Res 68
  
  Pages: 901-8
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390455
[Journal Article] Induction of EBV-latent membrane protein l-specific MHC class II-restricted T-cell responses against natural killer lymphoma cells.2008
- Author(s)
  Kobayashi H
- Journal Title
  
  Cancer Research 68
  
  Pages: 901-908
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390455
[Journal Article] Induction of EBV-latent membrane protein 1-specific MHC class II-restricted T-cell responses against natural killer lymphoma cells.2008
- Author(s)
  Kobayashi H, Nagato T, Takahara M, Sato K, Kimura S, Aoki N, Azumi M, Tateno M, Harabuchi Y, Celis E.
- Journal Title
  
  Cancer Res. 68
  
  Pages: 901-908
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390438
[Journal Article] Induction of EBV-latent membrane protein 1-specific MHC class ll-restrictedT-cell responses against natural killer lymphoma cells2008
- Author(s)
  Hiroya, Kobayashi.
- Journal Title
  
  Cancer Research 68
  
  Pages: 901-908
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590360
[Journal Article] Esteban Cells. Induction of EBV-Latent Membrane Protein I-Specific MHC Class II-Restricted T-Cell Responses against Natural Killer Lymphoma Cells2008
- Author(s)
  Kobayashi H. Nagato T, Takahara M
- Journal Title
  
  Cancer Res 68
  
  Pages: 901-908
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390438
[Journal Article] Recognition of prostate and melanoma tumor cells by six-transmembrane epithelial antigen of prostate-specific helper Tlymphocytes in a human leukocyte antigen class ll-restricted manner2007
- Author(s)
  Hiroya, Kobayashi.
- Journal Title
  
  Cancer Research 67
  
  Pages: 5498-5504
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590360
[Journal Article] Recognition of prostate and melanoma tumor cells by six-transmembrane epithelial antigen of prostate-specific helper T lymphocytes in a human leukocyte antigen class II-restricted manner.2007
- Author(s)
  Kobayashi H, Nagato T, Sato K, Aoki N, Kimura S, Murakami M, Iizuka H, Azumi M, Kakizaki H, Tateno M, Celis E.
- Journal Title
  
  Cancer Res. 67
  
  Pages: 5498-5504
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590360
[Journal Article] Induction of EBV-latent membrane protein 1-specific MHC class II-restricted T-cell responses against natural killer lymphoma cells.2007
- Author(s)
  Kobayashi H
- Journal Title
  
  Cancer Research 68
  
  Pages: 901-908
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390455
[Journal Article] In Vitro Peptide Immunization of Target Tax Protein Human T-cell Leukemia Virus-Specific CD4^+ Helper T Lymphocytes2006
- Author(s)
  Hiroya Kobayashi
- Journal Title
  
  Clinical Cancer Research 12・12
  
  Pages: 3814-3822
- Data Source
  KAKENHI-PROJECT-18590360
[Journal Article] Recognition of prostate and breast tumor cells by helper T lymphocytes specific for a prostate and breast tumor-associated antigen, TARP.2005
- Author(s)
  Hiroya Kobayashi
- Journal Title
  
  Clinical Cancer Research 11・11
  
  Pages: 3869-3878
- Data Source
  KAKENHI-PROJECT-16790220
[Journal Article] Expression of Interleukin-9 in Nasal Natural Killer/T-cell Lymphoma Cell Lines and Patients.2005
- Author(s)
  Nagato T, Kobayashi H, Kishibe K, Takahara M, Ogino T, Ishii H, Oikawa K, Aoki N, Sato K, Kimura S, Simizu N, Tateno M, Harabuchi Y.
- Journal Title
  
  Clin Cancer Res 11
  
  Pages: 8250-8257
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390455
[Journal Article] Defining MHC class II T helper epitopes for WT1 tumor antigen
- Author(s)
  Hiroya Kobayashi
- Journal Title
  
  Cancer Immunology Immunotherapy (in press)
- Data Source
  KAKENHI-PROJECT-16790220
[Patent] がん抗原ペプチド2018
- Inventor(s)
  小林博也、大栗敬幸、小坂朱
- Industrial Property Rights Holder
  小林博也、大栗敬幸、小坂朱
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-024972
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-16K15244
[Patent] がん抗原ペプチド2017
- Inventor(s)
  大栗敬幸、小林博也、小坂朱
- Industrial Property Rights Holder
  大栗敬幸、小林博也、小坂朱
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-072183
- Filing Date
  2017-03-18
- Data Source
  KAKENHI-PROJECT-16K15244
[Presentation] リン酸化ビメンチンを標的抗原とした転移性大腸癌に対する免疫療法2020
- Author(s)
  大原賢三、熊井琢美、長門利純、林　隆介、矢島優己、大栗敬幸、小林博也．
- Organizer
  第24回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-19K07452
[Presentation] Expression of cyclin-dependent kinase 1 and survivin in nasal natural killer/T-cell lymphoma2019
- Author(s)
  Hayashi R, Nagato T, Harabuchi S, Kumai T, Kishibe K, Takahara M, Kobayashi H, Harabuchi Y
- Organizer
  ISIAN・IRS・ARS (RhinoWorld Chicago 2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02948
[Presentation] 鼻性NK/T細胞リンパ腫および上咽頭癌におけるCD74とMIFの発現2019
- Author(s)
  熊井琢美, 林　隆介, 長門利純, 原渕翔平, 岸部　幹, 高原　幹, 永田真莉乃, 矢島優己, 小坂　朱, 大栗敬幸, 及川賢輔, 小林博也, 原渕保明
- Organizer
  第16回EBウイルス研究会
- Data Source
  KAKENHI-PROJECT-18H02948
[Presentation] 鼻性NK/T細胞リンパ腫におけるCD27の発現2019
- Author(s)
  長門利純, 林　隆介, 原渕翔平, 野﨑　結, 大原賢三, 熊井琢美, 岸部　幹, 高原　幹, 小林博也, 原渕保明
- Organizer
  第37回日本耳鼻咽喉科免疫アレルギー学会
- Data Source
  KAKENHI-PROJECT-18H02948
[Presentation] Cancer Immunity Cycleと化学療法2019
- Author(s)
  原渕翔平, 大原賢三, 野﨑　結, 熊井琢美, 長門利純, 林　達哉, 小林博也, 原渕保明
- Organizer
  第37回日本耳鼻咽喉科免疫アレルギー学会
- Data Source
  KAKENHI-PROJECT-18H02948
[Presentation] マウス扁平上皮癌モデルを用いた、化学療法とSTING活性化療法の併用に関する基礎研究2019
- Author(s)
  原渕翔平, 大栗敬幸, 小坂　朱, 永田真莉乃, 林　隆介, 大原賢三, 大原みずほ, 長門利純, 及川賢輔, 小林博也
- Organizer
  第108回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-18H02948
[Presentation] 癌特異的な翻訳後修飾を受けたp53タンパク質は特異的T細胞応答を惹起する2019
- Author(s)
  大原賢三, 大栗敬幸, 長門利純, 小林博也
- Organizer
  第23回日本がん免疫学会
- Data Source
  KAKENHI-PROJECT-18H02948
[Presentation] 頭頸部悪性腫瘍におけるCD74の発現2019
- Author(s)
  林　隆介, 長門利純, 永田真莉乃, 原渕翔平, 大原賢三, 大原みずほ, 小坂朱, 大栗敬幸, 及川賢輔, 小林博也
- Organizer
  第108回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-18H02948
[Presentation] Expression of cell surface CD74 and macrophage migration inhibitory factor in malignant tumors of head and neck region2019
- Author(s)
  Hayashi R, Nagato T, Kumai T, Nagata M, Harabuchi S, Yajima Y, Kosaka A, Ohkuri T, Oikawa K, Kishibe K, Takahara M, Harabuchi Y, Kobayashi H
- Organizer
  第78回日本癌学会
- Data Source
  KAKENHI-PROJECT-18H02948
[Presentation] 鼻性NK/T細胞リンパ腫における免疫抑制サイトカインの検討2019
- Author(s)
  熊井琢美, 長門利純, 岸部　幹, 高原　幹, 青木直子, 及川賢輔, 林　達哉, 小林博也, 原渕保明
- Organizer
  第37回日本耳鼻咽喉科免疫アレルギー学会
- Data Source
  KAKENHI-PROJECT-18H02948
[Presentation] 鼻性NK/T細胞リンパ腫における免疫抑制サイトカインの検討2019
- Author(s)
  熊井琢美、長門利純、林隆介、原渕翔平、岸部幹、高原幹、林達哉、小林博也、原渕保明
- Organizer
  第37回日本耳鼻咽喉科免疫アレルギー学会
- Data Source
  KAKENHI-PROJECT-18H02948
[Presentation] リン酸化抗原特異的T細胞を利用した悪性腫瘍に対するペプチドワクチン療法の基礎的解析2019
- Author(s)
  大原賢三, 熊井琢美, 長門利純, 林　隆介, 原渕翔平, 小林博也, 原渕保明
- Organizer
  第37回日本耳鼻咽喉科免疫アレルギー学会
- Data Source
  KAKENHI-PROJECT-18H02948
[Presentation] リン酸化ビメンチンを標的とした免疫療法の基礎的解析2019
- Author(s)
  大原賢三、大原みずほ、長門利純、大栗敬幸、小坂朱、林隆介、永田真莉乃、原渕翔平、及川賢輔、小林博也
- Organizer
  第１０８回　日本病理学会総会
- Data Source
  KAKENHI-PROJECT-19K07452
[Presentation] 鼻性NK/T細胞リンパ腫におけるCD74とMIFの発現2019
- Author(s)
  林　隆介, 長門利純, 原渕翔平, 熊井琢美, 岸部　幹, 高原　幹, 小林博也, 原渕保明
- Organizer
  第58回日本鼻科学会
- Data Source
  KAKENHI-PROJECT-18H02948
[Presentation] Expression of programmed death-ligand 1 in nasal natural killer/T-cell lymphoma2018
- Author(s)
  Nagato t, Ohkuri T, Ohara K, Nozaki Y, Kishibe K, Takahara M, Kumai T, Araki D, Komabayashi H, Kobayashi H, Harabuchi Y
- Organizer
  International Conference on EBV & KSHV 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02948
[Presentation] 鼻性NK/T細胞リンパ腫におけるCDK1とサバイビンの発現2018
- Author(s)
  長門利純、大原賢三、原渕翔平、林隆介、大栗敬幸、永田真莉乃、大原みずほ、小坂朱、青木直子、及川賢輔、原渕保明、小林博也
- Organizer
  第51回北海道病理談話会
- Data Source
  KAKENHI-PROJECT-18H02948
[Presentation] ワークショップ１０：「病理学的解析が拓くがん免疫研究の進展と未来」鼻性NK/T細胞リンパ腫における免疫抑制機構の解明と新規免疫療法の開発2018
- Author(s)
  長門利純、原渕保明、小林博也
- Organizer
  第107回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-18H02948
[Presentation] 鼻性NK/T細胞リンパ腫における免疫抑制サイトカインの検討2018
- Author(s)
  熊井琢美、長門利純、岸部幹、高原幹、青木直子、及川賢輔、林達哉、小林博也、原渕保明
- Organizer
  第15回EBウイルス研究会
- Data Source
  KAKENHI-PROJECT-18H02948
[Presentation] Neuropeptide signaling through NK2R is related to tumorigenesis in vivo2017
- Author(s)
  Huihui Xiang, Yujiro Toyoshima, Satoshi Terada, Shinichi Hashimoto, Kazuho Ikeo, Hiroya Kobayashi, Shigenori Homma, Hideki Kawamura, Norihiko Takahashi, Akinobu Taketomi, Hidemitsu Kitamura
- Organizer
  The 36th Sapporo International Cancer Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08416
[Presentation] 神経ペプチド受容体を介した腫瘍形成メカニズムの解明と新規がん治療法への応用2017
- Author(s)
  北村秀光、項慧慧、豊島雄二郎、木井修平、橋本真一、池尾一穂、小林博也、本間重紀、川村秀樹、高橋典彦、武冨紹信
- Organizer
  第21回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-15K08416
[Presentation] Neuropeptide signaling through NK1R and NK2R of cancer cells is required for promotion of tumorigenesis in vivo2016
- Author(s)
  Huihui Xiang, Yujiro Toyoshima, Satoshi Terada, Shigenori Homma, Hideki Kawamura, Norihiko Takahashi, Akinobu Taketomi, Hiroya Kobayashi, Hidemitsu Kitamura
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K08416
[Presentation] 神経ペプチドシグナルによる腫瘍形成促進メカニズムの解明と新規がん治療法への応用2016
- Author(s)
  項慧慧, 豊島雄二郎, 寺田聖, 本間重紀, 川村秀樹, 高橋典彦, 武冨紹信, 小林博也, 北村秀光
- Organizer
  第20回日本がん免疫学会総会
- Place of Presentation
  大阪国際交流センター（大阪府・大阪市）
- Year and Date
  2016-07-27
- Data Source
  KAKENHI-PROJECT-15K08416
[Presentation] Neuropeptide signaling through NK1R and NK2R is related to inflammation and tumorigenesis in vivo2016
- Author(s)
  Huihui Xiang, Yujiro Toyoshima, Satoshi Terada, Shigenori Homma, Hideki Kawamura, Norihiko Takahashi, Akinobu Taketomi, Hiroya Kobayashi, Hidemitsu Kitamura
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター、ラグナガーデンホテル（沖縄県・宜野湾市）
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-15K08416
[Presentation] EGFR阻害薬による抗腫瘍免疫への影響について2015
- Author(s)
  熊井琢美、大栗敬幸、小坂朱、長門利純、石橋佳、大原賢三、平田結、及川賢輔、原渕保明、小林博也
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋市
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25460430
[Presentation] A novel mechanism for activating Type-1 immunity by neuropeptide signalings through NK1R and NK2R in tumor microenvironments2015
- Author(s)
  Takayuki Ohkuri, Junya Ohtake, Shun Kaneumi, Hidemitsu Kitamura, Hiroya Kobayashi
- Organizer
  The 10th International Symposium of the Institute Network “Towards the next generation research for cancer and immunology”
- Place of Presentation
  北海道大学医学部学友会館「フラテ」（北海道・札幌市）
- Year and Date
  2015-07-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08416
[Presentation] Neuropeptide signalings enhance cytokine production by antigen-specific T cells through activation of human dendritic cells2015
- Author(s)
  Hidemitsu Kitamura, Junya Ohtake, Shun Kaneumi, Mishie Tanino, Takuto Kishikawa, Satoshi Terada, Kentaro Sumida, Kazutaka Masuko, Toshiyuki Kita, Sadahiro Iwabuchi, Shinya Tanaka, Hiroya Kobayashi
- Organizer
  第44回日本免疫学会学術総会・学術集会
- Place of Presentation
  札幌コンベンションセンター（北海道・札幌市）
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-15K08416
[Presentation] EGFR阻害薬によって腫瘍から放出される抑制性サイトカインは抗腫瘍免疫を低下させうる2015
- Author(s)
  熊井琢美、大栗敬幸、石橋佳、及川賢輔、青木直子、小林博也
- Organizer
  第104回日本病理学会総会
- Place of Presentation
  名古屋市
- Year and Date
  2015-04-30
- Data Source
  KAKENHI-PROJECT-25460430
[Presentation] セツキシマブの抗体依存性細胞障害活性に対するステロイドの影響2015
- Author(s)
  長門利純、熊井琢美、平田結、大原賢三、石橋佳、大栗敬幸、小坂朱、及川賢輔、小林博也、原渕保明
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋市
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25460430
[Presentation] c- Met 及びオートファジーを標的としたヘルパー T 細胞による癌免疫治療の確立2014
- Author(s)
  熊井琢美、及川賢輔、青木直子、木村昭治、小林博也
- Organizer
  第103回日本病理学会総会
- Place of Presentation
  広島市
- Year and Date
  2014-04-25
- Data Source
  KAKENHI-PROJECT-25460430
[Presentation] EGFR inhibition augments anti-tumor immune responses by HER family-specific human CD4 helper T cells in vitro2013
- Author(s)
  Kumai, T.,Harabuchi, Y., Kobayashi, H.
- Organizer
  American Association for Cancer Research Annual Meeting
- Place of Presentation
  Washington DC
- Data Source
  KAKENHI-PROJECT-25460430
[Presentation] Autophagy regulates c-Met specific helper T cells anti-tumor responses in vitro2013
- Author(s)
  熊井琢美、松田佳也、及川賢輔、原渕保明、小林博也
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-25460430
[Presentation] EGFR反応性CD4陽性ヘルパーT細胞クローンの樹立及びEGFR阻害薬のアジュバントとしての有用性2013
- Author(s)
  熊井琢美、青木直子、木村昭治、小林博也
- Organizer
  第102回日本病理学会総会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-25460430
[Presentation] EGFR反応性CD4陽性ヘルパーT細胞クローンの樹立及びEGFR阻害薬のアジュバントとしての有用性2013
- Author(s)
  熊井琢美、小林博也、原渕保明
- Organizer
  第114回日本耳鼻咽喉科学会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-25460430
[Presentation] Tヘルパー応答から考察した癌抗原タンパク質としてのAurora-A kinaseの有用性2010
- Author(s)
  小林博也
- Organizer
  第99回日本病理学会総会
- Place of Presentation
  東京都
- Year and Date
  2010-04-29
- Data Source
  KAKENHI-PROJECT-21590424
[Presentation] 癌免疫、アレルギー制御に関わるHLAクラスII分子結合性ペプチド抗原の分子病理学的解析2010
- Author(s)
  小林博也(代表者)
- Organizer
  第56回日本病理学会秋期特別総会
- Place of Presentation
  北九州市
- Data Source
  KAKENHI-PROJECT-21590424
[Presentation] Tヘルパー応答から考察した癌抗原タンパク質してのAurora-A kinaseの有用性2010
- Author(s)
  小林博也(代表者)
- Organizer
  第99回日本病理学会総会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-21590424
[Presentation] Tヘルパー応答から考察した免疫標的分子としてのFAKの可能性2009
- Author(s)
  小林博也
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-21590424
[Presentation] 免疫標的分子としてのFocal adhesion kinase(FAK)の可能性2009
- Author(s)
  小林博也
- Organizer
  第98回日本病理学会総会
- Place of Presentation
  京都
- Year and Date
  2009-05-01
- Data Source
  KAKENHI-PROJECT-21590424
[Presentation] Tヘルパー応答から考察した免疫標的分子としてのFAKの可能性2009
- Author(s)
  小林博也(代表者)
- Organizer
  第68回日本癌学会総会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-21590424
[Presentation] 免疫標的分子としてのFocal adhesion kinase(FAK)の可能性2009
- Author(s)
  小林博也(代表者)
- Organizer
  第98回日本病理学会総会
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-21590424
[Presentation] Recognition of prostate and melanoma tumors by STEAP-specific helper T lymphocytes in a HLA class II-restricted manner.2007
- Author(s)
  Hiroya Kobayashi, et. al.
- Organizer
  66^<th> Annual Meeting of the Japanese Cancer Association
- Year and Date
  2007-10-05
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590360
[Presentation] 癌抗原STEAPを認識するヘルパーT細胞の誘導とそのpromiscuousエピトープ2007
- Author(s)
  小林博也
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  横浜市
- Year and Date
  2007-10-05
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590360
[Presentation] C-C chemokine receptor 4 is a remarkable molecule for novel targeted therapy against nasal natural killer/T-cell lymphoma
- Author(s)
  Toshihiro Nagato, Takumi Kumai, Hiroya Kobayashi, Yuki Komabayashi, Seigo Ueda, Kan Kishibe, Miki Takahara, Yasuaki Harabuchi
- Organizer
  16th International Symposium on EBV
- Place of Presentation
  Brisbane, Australia
- Year and Date
  2014-07-16 – 2014-07-19
- Data Source
  KAKENHI-PROJECT-24390385
[Presentation] 鼻性NK/T細胞リンパ腫における新規c-Metヘルパーエピトープの探索
- Author(s)
  熊井琢美、松田佳也、及川賢輔、木村昭治、原渕保明、小林博也
- Organizer
  第46回北海道病理談話会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-25460430

1. NAGATO Toshihiro (80431419)

# of Collaborated Projects: 8 results

# of Collaborated Products: 31 results
2. HARABUCHI Yasuaki (80208686)

# of Collaborated Projects: 7 results

# of Collaborated Products: 30 results
3. OHKURI Takayuki (70564061)

# of Collaborated Projects: 7 results

# of Collaborated Products: 17 results
4. TAKAHARA Miki (50322904)

# of Collaborated Projects: 6 results

# of Collaborated Products: 20 results
5. KISHIBE Kan (80447101)

# of Collaborated Projects: 6 results

# of Collaborated Products: 16 results
6. Kumai Takumi (00596306)

# of Collaborated Projects: 5 results

# of Collaborated Products: 26 results
7. 小坂朱 (40561030)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
8. 大原賢三 (20596308)

# of Collaborated Projects: 3 results

# of Collaborated Products: 16 results
9. BANDOH Nobuyuki (60312469)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. UEDA Seigo (90447102)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
11. KOMABAYASHI Yuki (40548864)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
12. KATAYAMA Akihiro (40374805)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. KATAGIRI Makoto (10041823)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. SATO Keisuke (10250549)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. KIMURA Shyoji (00250548)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. AOKI Naoko (60301983)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. OGINO Takeshi (00312455)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. Kitamura Hidemitsu (40360531)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
19. 石井秀幸 (90360982)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. TANINO Mishie

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 谷野功典

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KOBAYASHI Hiroya 小林 博也

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免疫抑制性腫瘍微小環境の打破に関わる基盤的複合癌免疫療法の開発研究Principal Investigator

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cGAS/STING/I型IFN経路を基軸とした癌免疫微小環境のホット化治療戦略Principal Investigator

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Epithelial mesenchymal transition (EMT)-associated proteins as potent immunotherapeutic target for canner immunotherapyPrincipal Investigator

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Analysis of stealth antigens for developing tumor immunotherapyPrincipal Investigator

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Assessment of T-cell based immunotherapy targeting EGFR with immune-molecular targeted combination therapy for treatment of reflactory cancer.Principal Investigator

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Developing T-cell based immunotherapy using ubiquitously expressing tumor-associated antigen, Aurora-A kinase and FAKPrincipal Investigator

KOBAYASHI Hiroya 小林博也