TAKAHASHI Mariko 高橋真理子

Researcher Number	90334440
Other IDs
Affiliation (based on the past Project Information) *help	2013 – 2018: 東京医科歯科大学, 歯学部, 技術職員 2017: 東京医科歯科大学, 歯学部, 技術系職員 2013 – 2014: 東京医科歯科大学, 歯学部, 教室系技術職員 2012: 東京医科歯科大学, 大学院・医歯学総合研究科, 技術職員 2007 – 2009: 東京医科歯科大学, 歯学部, 技術職員 2001 – 2006: Tokyo Medical and Dental University, Graduate School, Hard Tissue Pharmacology, Technician, 歯学部, 教務職員
Review Section/Research Field	Principal Investigator Functional basic dentistry / Dental engineering/Regenerative dentistry Except Principal Investigator Functional basic dentistry / Functional basic dentistry / Orthopaedic surgery
Keywords	Principal Investigator カテプシンK阻害薬 / PTH / 骨形成促進薬 / 骨吸収抑制薬 / 炎症抑制薬 / 食事療法 / 歯周炎 / インプラント / 炎症性骨吸収 / HbA1c … More / 歯周病 / アンタゴニスト / TNF-α / ペプチド創薬 / 骨吸収 / 血糖値 / 糖尿病 / RNAアプタマー / PD-1 / 破骨細胞 … More Except Principal Investigator TNF / RANKL / 破骨細胞 / RANK / 骨吸収 / 歯周病 / 骨粗鬆症 / 骨形成 / osteoclasts / periodontitis / bone resorption / bisphosphonates / Walker 256 / ラット / 低Ca食 / リウマチ / 炎症 / ナノゲル / 骨形成促進 / 骨芽細胞 / 軟骨形成 / ペプチド / ゼラチンハイドロゲル / RANKL結合ペプチド / ラベリング法 / 軟骨変性抑制 / Mini-pump / Nano-gel / Rheumatoid Arthritis / NF-kβ / ミニポンプ / ナノ・ゲル / bone loss / inflammation / osteoclastogenesis / drug development / critical contact site / 骨吸収抑制 / 炎症抑制 / CIAモデル / 環状ペプチド / 破骨細胞形成抑制 / 構造生物学 / 骨量低下 / 破骨細胞形成 / 薬物開発 / 接触ポイント / 腫瘍壊死因子(TNF) / inhibitroy drugs for bone resorption / s carcinoma cells / osteoblasts / osteoporosis / Walker256 / 骨吸収抑制薬 / s癌細胞 / Biphosphinates / confocal laser-scanning microscope / bone mineral density / intracellular calcium / distraction osteogenesis / hyper-tension / osteoclast / high salt intake / a low calcium diet / 骨形態計測 / ウサギ / 骨塩素測定 / 共焦点レーザー走査顕微鏡 / 骨塩量測定 / 細胞内カルシウム / 仮骨延長法 / 高血圧症 / 高食塩摂取 / LPS / TNF2型受容体 / ペプチドアンタゴニスト / BMP / ペプチド薬 / DDS / 抗炎症 / 骨吸収阻害薬 / 炎症性疾患 / 硬組織 / TNF拮抗薬 / NF-kB / 低Ca食飼育食マウス / 骨吸収阻害 / NF-κB / TNF受容体 Less

Consideration of inhibitory effect for inflammatory bone resorption with Cathepsin K inhibitors and Parathormone.Principal Investigator
- Principal Investigator
  
  TAKAHASHI Mariko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dental engineering/Regenerative dentistry
- Research Institution
  Tokyo Medical and Dental University
A new drug development for accelerating bone and/or cartilage formation by RANK-like peptide
- Principal Investigator
  
  HASEGAWA Nozomi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokyo Medical and Dental University
New bone resrption inhibitor based on agonistic function for TNF type 2 receptor
- Principal Investigator
  
  OHYA Keiichi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Functional basic dentistry
- Research Institution
  Tokyo Medical and Dental University
Development of new peptide agent for improvements in diabetes mellitus and periodontal disease symptomsPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Mariko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Tokyo Medical and Dental University
Development of TNF-receptor Antagonists which have both Anti-inflammatory Action and Bone Formation Activity and Apply Them for the Treatment of Periodontal Diseases.
- Principal Investigator
  
  OHYA Keiichi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Tokyo Medical and Dental University
Inhibition of bone resorption by RNA aptamer for immunoregulatory receptor PD-1 induced on activated T cell.Principal Investigator
- Principal Investigator
  
  TAKAHASHI Mariko
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Tokyo Medical and Dental University
Development of new therapeutic drugs for inflammatory bone destruction by the CIAM compound, a new TNF receptor antagonist.
- Principal Investigator
  
  OHYA Keiichi
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Tokyo Medical and Dental University
Development of New Hybrid-type Drugs Targeted to the Mechanism of Bone Remodeling
- Principal Investigator
  
  OHYA Keiichi
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Tokyo Medical and Dental University
Search for the new target points of bisphosphonates in bone cells: Their inhibitory actions on bone resorption and the stimulatory actions on bone formation
- Principal Investigator
  
  OHYA Keiichi
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Tokyo Medical and Dental University
The epoch-making drug development of the inhibitor blocking inflammatory bone destruction in alveolar bones.
- Principal Investigator
  
  AOKI Kazuhiro
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Tokyo Medical and Dental University
Regulation of bone resorption in jaw by the drug administration. Analysis by the 3D-bone histomorphometry and by the measurement of bone mineral density.
- Principal Investigator
  
  OHYA Keiichi
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Tokyo Medical and Dental University

All 2018 2015 2013 2010 2007 2003 Other

All Journal Article Presentation

[Journal Article] Beneficial effects of fasting regimens on periodontal tissues in experimental periodontitis mice model.2018
- Author(s)
  Lia Kartika Wulansari, Boosana Kaboosaya, Masud Khan, Mariko Takahashi, Hidemi Nakata, Shinji Kuroda, Kazuhiro Aoki, Shohei Kasugai
- Journal Title
  
  Journal of International Dental and Medical Research
  
  Volume: 11 Pages: 362-369
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K11647
[Journal Article] Nanogel-crosslinked nanoparticles increase the inhibitory effects of W9 synthetic peptide on bone loss in a murine bone resorption model2015
- Author(s)
  Toshimi Sato, Neil Alles, Masud Khan, Kenichi Nagano, Mariko Takahashi, Yukihiko Tamura, Asako Shimoda, Keiichi Ohya, Kazunari Akiyoshi, Kazuhiro Aoki
- Journal Title
  
  International Journal of Nanomedicine
  
  Volume: 10 Pages: 3459-3473
- DOI
  10.2147/ijn.s61566
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25670787, KAKENHI-PROJECT-25293377
[Journal Article] The inhibitory effects of a RANKL-binding peptide on articular and periarticular bone loss in a murine model of collagen-induced arthritis: A bone histomorphometric study.2015
- Author(s)
  Kato G, Shimizu Y, Arai Y, Suzuki N, Sugamori Y, Maeda M, Takahashi M, Tamura Y, Wakabayashi N, Murali R, Ono T, Ohya K, Mise-Omata S, Aoki K.
- Journal Title
  
  Arthritis Research & Therapy
  
  Volume: Sep 12 Issue: 1 Pages: 251-264
- DOI
  10.1186/s13075-015-0753-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26861771, KAKENHI-PROJECT-25462392, KAKENHI-PROJECT-25861753, KAKENHI-PROJECT-25293377
[Journal Article] A tumor necrosis factor receptor loop peptide mimic inhibits bone destruction to the same extent as anti-tumor necrosis factor monoclonal antibody in murine collagen-induced arthritis.2007
- Author(s)
  Saito H, Kojima T, Takahashi M, Horne WC, Baron R, Amagasa T, Ohya K, Aoki K.
- Journal Title
  
  Arthritis and rheumatism 56
  
  Pages: 1164-1174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390471
[Journal Article] A tumor necrosis factor receptor loop peptide mimic inhibits bone destruction to the same extent as anti-tumor necrosis factor monoclonal antibody in murine collagen-induced arthritis2007
- Author(s)
  Saito H, Kojima T, Takahashi M, Horne WC, Baron R, Amagasa T, Ohya K, Aoki K
- Journal Title
  
  Arthritis Rheum 56
  
  Pages: 1164-1174
- Data Source
  KAKENHI-PROJECT-19390471
[Journal Article] Clodronate Stimulates Bone Formation as well as Inhibits Bone Resorption and Increases Bone Mineral Density in Rats Fed a Low-Calcium Diet.2003
- Author(s)
  D.Horie, M.Takahashi, K.Aoki, K.Ohya
- Journal Title
  
  Journal of Medical and Dental Science 50
  
  Pages: 121-132
- NAID
  110000076026
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13557151
[Journal Article] Clodronate Stimulates Bone Formation as well as Inhibits Bone Resorption and Increases Bone Mineral Density in Rats Fed a Low-Calcium Diet.2003
- Author(s)
  D.Horie, M.Takahashi, K.Aoki, K.Ohya
- Journal Title
  
  Journal of Medical and Dental Science. 50
  
  Pages: 121-132
- NAID
  110000076026
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13557151
[Journal Article] Defective NIK in aly/aly mice prevents bone resorption induced by local injection of Lipopolysaccharide.
- Author(s)
  Soysa NS, Alles N, Takahashi M, Aoki K, Ohya K
- Journal Title
  
  Journal of Periodontology (投稿中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791350
[Presentation] An Osteoprotegerin-like Peptide Inhibits Bone Loss in Collagen Type II-Induced Murine Arthritis.2013
- Author(s)
  Kato, G. Maeda, M. Alles, N. Mamun, A. Khan, M. Sugamori, Y. Takahashi, M. Tamura, Y. Murali, R. Ohya, K. Aoki, K.
- Organizer
  IBMS/JSBMR第2回合同国際会議
- Place of Presentation
  神戸/神戸コンベンションセンター・神戸ポートピアホテル
- Data Source
  KAKENHI-PROJECT-24390413
[Presentation] TNF-α制御による顎骨骨量増生への薬理学的アプローチ2010
- Author(s)
  中地浩之、高橋真理子、青木和広、大谷啓一, 他5名
- Organizer
  第8回日本歯科骨粗鬆症研究会
- Place of Presentation
  東京
- Year and Date
  2010-04-04
- Data Source
  KAKENHI-PROJECT-20791350
[Presentation] RANKL結合ペプチドの骨吸収抑制作用と骨形成促進作用
- Author(s)
  青木和広、菅森泰隆、加藤玄樹、上原智己、新井祐貴、Md.Zahirul Haq Bhuyan、Neil Alles、Masud Khan、高橋真理子、田村幸彦、若林則幸、大谷啓一
- Organizer
  第56回歯科基礎医学会学術大会・総会
- Place of Presentation
  福岡
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-24390413
[Presentation] RANKL結合ペプチドの骨吸収抑制作用と骨形成促進作用
- Author(s)
  青木和広、菅森泰隆、加藤玄樹、上原智己、新井祐貴、Md.Zahirul Haq Bhuyan、Neil Alles、Masud Khan、高橋真理子、田村幸彦、若林則幸、大谷啓一
- Organizer
  第56回歯科基礎医学会学術大会
- Place of Presentation
  福岡国際会議場(福岡市)
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25670787

1. AOKI Kazuhiro (40272603)

# of Collaborated Projects: 9 results

# of Collaborated Products: 10 results
2. OHYA Keiichi (10126211)

# of Collaborated Projects: 6 results

# of Collaborated Products: 6 results
3. JIMI Eijiro (40276598)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. NIFUJI Akira (00240747)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. YAMADA Sachiko (10014078)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. AZUMA Miyuki (90255654)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SHIMOKAWA Hitoyata (80014257)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. HASEGAWA Nozomi (50770228)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. HONMA Masashi (60401072)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KAMATA Haruhiko (00324509)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. TABATA Yasuhiko (50211371)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 柴田達也 (90323708)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 澄川万紀 (10216492)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 田村幸彦 (40188446)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. WAKI Yoshihiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. NONAKA Kiichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. YOSHINARI Yuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. MAEDA Chizuko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. BHUYAN Md Zahirul Haque

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. YASUHIRO Shimizu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TAKAHASHI Mariko 高橋 真理子

Research Projects

Research Products

Co-Researchers

Consideration of inhibitory effect for inflammatory bone resorption with Cathepsin K inhibitors and Parathormone.Principal Investigator

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Development of new peptide agent for improvements in diabetes mellitus and periodontal disease symptomsPrincipal Investigator

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Inhibition of bone resorption by RNA aptamer for immunoregulatory receptor PD-1 induced on activated T cell.Principal Investigator

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[Journal Article] Beneficial effects of fasting regimens on periodontal tissues in experimental periodontitis mice model.2018

Author(s)

Journal Title

Data Source

[Journal Article] Nanogel-crosslinked nanoparticles increase the inhibitory effects of W9 synthetic peptide on bone loss in a murine bone resorption model2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The inhibitory effects of a RANKL-binding peptide on articular and periarticular bone loss in a murine model of collagen-induced arthritis: A bone histomorphometric study.2015

Author(s)

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DOI

Data Source

[Journal Article] A tumor necrosis factor receptor loop peptide mimic inhibits bone destruction to the same extent as anti-tumor necrosis factor monoclonal antibody in murine collagen-induced arthritis.2007

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Journal Title

Data Source

TAKAHASHI Mariko 高橋真理子