SUGIMOTO Hiroshi 杉本宏

Researcher Number	90344043
Other IDs	https://orcid.org/0000-0002-3140-8362
External Links
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 放射光科学研究センター, 専任研究員
Affiliation (based on the past Project Information) *help	2018 – 2024: 国立研究開発法人理化学研究所, 放射光科学研究センター, 専任研究員 2017: 理化学研究所, 放射光科学研究センター, 専任研究員 2015 – 2017: 国立研究開発法人理化学研究所, 放射光科学総合研究センター, 専任研究員 2013 – 2014: 独立行政法人理化学研究所, 放射光科学総合研究センター, 専任研究員 2011 – 2012: 独立行政法人理化学研究所, 城生体金属科学研究室, 専任研究員 … More 2009 – 2011: 理化学研究所, 城研, 研究員 2009: 城生体金属科学研究室, 専任研究員 2008: The Institute of Physical and Chemical Research, 城生体金属科学研究室, 専任研究員 2004 – 2008: RIKEN, Biometal Science Lab., Research Scientist, 城生体金属科学研究室, 研究員 2007: The Institute of Physical and Chemical Research, 城生体金属科学研究室, 研究員 2003: 独立行政法人理化学研究所, 生体物理化学研究室, 研究員 2002: 理化学研究所, 生体物理化学研究室, 研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 43020:Structural biochemistry-related / Complex systems / Biological Sciences / Structural biochemistry / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Structural biochemistry Except Principal Investigator Science and Engineering / Basic Section 38030:Applied biochemistry-related / Complex systems / Physical chemistry / Bioorganic chemistry / Applied biochemistry / Chemistry related to living body
Keywords	Principal Investigator ヘム / X線結晶構造解析 / X線 / トランスポーター / XFEL / X線自由電子レーザー / 金属タンパク質 / ヘムタンパク質 / X線結晶学 / 膜輸送 … More / 構造解析 / 膜タンパク質 / ATP / ABCトランスポーター / クライオ電子顕微鏡 / X線回折 / ビタミンC / 電子伝達 / 蛋白質 / X線構造解析 / 量子ビーム / 生体分子 / 結晶 / 金属イオン / 鉄イオン / センサータンパク質 / 構造生物学 / トリプトファン / 共鳴ラマン分光 / 受容体 / 結晶構造 / チロシンキナーゼ / 成長因子 / 血管新生 … More Except Principal Investigator X線結晶構造解析 / ヘム / 金属酵素 / シトクロムP450 / 一酸化窒素還元酵素 / 脱窒 / 一酸化窒素 / キヌレニン経路 / ヘム酵素 / ヘム鉄 / トリプトファン代謝 / 二原子酸素添加酵素 / 酵素反応 / 電子スピン共鳴 / 熱安定性 / 耐圧酵素 / 低温適応酵素 / 電子常磁性共鳴 / GPI アンカー / SMPD1 / 銅 / チロシナーゼ / メラニン / 体内動態 / 攪乱 / 有害金属 / 相互作用 / メタレーション / マンガン / 撹乱 / 毒性金属 / 吸収 / 亜鉛酵素 / 金属配位 / 生命金属 / 亜鉛輸送体 / マイクロデバイス / 蛍光寿命測定 / 可視吸収分光法 / 赤外吸収分光法 / タンパク質ダイナミクス / 膜タンパク質 / 分光法 / 時間分解測定 / マイクロ流体デバイス / ダイナミクス / 顕微分光測定 / ABCトランスポーター / 時間分解計測 / 赤外分光法 / X線自由電子レーザー / 顕微分光 / マイクロ流路デバイス / 時間分解分光法 / coordination Chemistry / Metal-enzymes / Signal Transduction / Bio-synthesis / Metalloproteins / 非ヘム鉄 / エチレンセンサー蛋白質 / 酵素センサー蛋白質 / ヒスチジンキナーゼ / 金属配位空間 / 感染症 / 老人性白内障 / 配位構造 / センサー蛋白質 / 二成分情報伝達系 / 配位化学 / 情報変換 / 金属蛋白質 / 物質変換 / X-ray Crystallography / Oxygenation / Heme-enzymes / Hydrogen Peroxide / Hydroxylation of Fatty Acids / Cytochrome P450 / 脂肪酸 / 反応機構 / モノオキシゲナーゼ / ペルオキシダーゼ / ペルオキシゲナーゼ / 酸素添加反応 / 過酸化水素 / 脂肪酸水酸化 / チトクロムP450 / 骨粗鬆症 / 癌 / ビタミンD / チトクロム酸化酵素 / 分子進化 / オゾン層破壊 / 温室効果ガス / 亜酸化窒素 / 呼吸酵素 / 酸素添加酵素 / 共鳴ラマン分光 / インドールアミン / 酸素分子 Less

新しい動的構造解析法の開発とABCトランスポーターへの応用Principal Investigator
- Principal Investigator
  
  杉本宏
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Institute of Physical and Chemical Research
EPR・X線による深海および南極海微生物由来酵素の高活性・高安定性機構の解明
- Principal Investigator
  
  堀谷正樹
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38030:Applied biochemistry-related
- Research Institution
  Saga University
Structure and mechanism of bacterial heme transporterPrincipal Investigator
- Principal Investigator
  
  Sugimoto Hiroshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Institute of Physical and Chemical Research
ヘム酵素が生成する酸化活性種の精密構造解析Principal Investigator
- Principal Investigator
  
  杉本宏
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Institute of Physical and Chemical Research
Structure analysis of monooxygenase using XFEL and microfluidic devicePrincipal Investigator
- Principal Investigator
  
  Sugimoto Hiroshi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Institute of Physical and Chemical Research
Protein metalation that controls biometal dynamics in the cells
- Principal Investigator
  
  Kambe Taiho
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Kyoto University
Strucutral analysis of the membrane proteins involved in metal transportPrincipal Investigator
- Principal Investigator
  
  Sugimoto Hiroshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Institute of Physical and Chemical Research
Structural analysis of bacterial heme transporterPrincipal Investigator
- Principal Investigator
  
  杉本宏
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Institute of Physical and Chemical Research
ヘムトランスポーターの動的結晶構造解析Principal Investigator
- Principal Investigator
  
  杉本宏
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Institute of Physical and Chemical Research
Development of time-resolved spectroscopic systems with micro-flow devices and their application to the molecular mechanism of ABC transporters
- Principal Investigator
  
  KIMURA TETSUNARI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Physical chemistry
- Research Institution
  Kobe University
病原微生物におけるヘム獲得システムの構造基盤Principal Investigator
- Principal Investigator
  
  杉本宏
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
Structure and mechanism of the iron transport system in humanPrincipal Investigator
- Principal Investigator
  
  Sugimoto Hiroshi
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Structural biochemistry
- Research Institution
  Institute of Physical and Chemical Research
病原微生物におけるヘムシグナリング複合体の構造学的研究Principal Investigator
- Principal Investigator
  
  杉本宏
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
Molecular Evolution of Respiratory Enzymes; Functional Conversion from NO Reduction to O2 Reduction
- Principal Investigator
  
  SHIRO Yoshitsugu
- Project Period (FY)
  2009 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Chemistry related to living body
- Research Institution
  The Institute of Physical and Chemical Research
Protein Engineering of vitamin D hydroxylases and design of their inhibitors based on their tertiary structure
- Principal Investigator
  
  SAKAKI Toshiyuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied biochemistry
- Research Institution
  Toyama Prefectural University
時間分割共鳴ラマン分光法による二原子酸素添加酵素の構造ダイナミクス
- Principal Investigator
  
  SHIRO Yoshitsugu
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  The Institute of Physical and Chemical Research
Analysis of oxygen activation mechanism in the heme-containing dioxygenasesPrincipal Investigator
- Principal Investigator
  
  SUGIMOTO Hiroshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  The Institute of Physical and Chemical Research
Bio-conversion of Substances and Information by Metal-containing Proteins and Enzymes
- Principal Investigator
  
  SHIRO Yoshitsugu
- Project Period (FY)
  2004 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  The Institute of Physical and Chemical Research
血管新生過程における情報伝達因子の構造学的研究Principal Investigator
- Principal Investigator
  
  杉本宏
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  The Institute of Physical and Chemical Research
Peroxygenase P450 as a Novel Bio-material
- Principal Investigator
  
  SHIRO Yoshitsugu, 松永勇
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  RIKEN
  Osaka City University

[Book] バクテリアのヘムトランスポーター（ヘムタンパク質の科学）2022
- Author(s)
  杉本宏（監修：斎藤正男、青野重利、城宜嗣）
- Total Pages
  472
- Publisher
  エヌ・ティー・エス
- ISBN
  9784860437787
- Data Source
  KAKENHI-PROJECT-21H02421
[Book] in Handbook of Porphyrin Science (K. M. Kadish, K. M. Smith, R. Guilard, Eds.) Vol. 5, Chapter 242011
- Author(s)
  H. Sugimoto, O. Takikawa, Y. Shiro
- Publisher
  Tryptophan Catabolism by Heme Dioxygenases
- Data Source
  KAKENHI-PROJECT-21245041
[Book] Handbook of Porphyrin Science (K.M.Kadish, K.M.Smith, R.Guilard, Eds.) Vol.5, Chapter 242010
- Author(s)
  H.Sugimoto, O.Takikawa, Y.Shiro
- Publisher
  World Scientific
- Data Source
  KAKENHI-PROJECT-21245041
[Journal Article] A redox switch allows binding of Fe(II) and Fe(III) ions in the cyanobacterial iron-binding protein FutA from <i>Prochlorococcus</i>2024
- Author(s)
  Bolton,Machelett.Stubbs,Axford,Caramello,Catapano,Mal,Rodrigues,Cordery,Tizzard,MacMillan,Engilberge,von Stetten,Tosha,Sugimoto,Worrall,Webb,Zubkov,Coles,Mathieu,Steiner,Murshudov,Schrader,Orville,Royant,Evans,Hough,Owen,Tews
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 121 Issue: 12 Pages: 1-6
- DOI
  10.1073/pnas.2308478121
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H04760, KAKENHI-PROJECT-21H02421
[Journal Article] Tetraphenylporphyrin Enters the Ring: First Example of a Complex between Highly Bulky Porphyrins and a Protein**2022
- Author(s)
  Shisaka Yuma、Sakakibara Erika、Suzuki Kazuto、Stanfield Joshua Kyle、Onoda Hiroki、Ueda Garyo、Hatano Miu、Sugimoto Hiroshi、Shoji Osami
- Journal Title
  
  ChemBioChem
  
  Volume: - Issue: 14
- DOI
  10.1002/cbic.202200095
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21J15614, KAKENHI-PROJECT-21H02421
[Journal Article] A Heme‐Acquisition Protein Reconstructed with a Cobalt 5‐Oxaporphyrinium Cation and Its Growth‐Inhibition Activity Toward Multidrug‐Resistant Pseudomonas aeruginosa2022
- Author(s)
  Takiguchi Asahi、Sakakibara Erika、Sugimoto Hiroshi、Shoji Osami、Shinokubo Hiroshi
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 61 Issue: 7 Pages: 202112456-202112456
- DOI
  10.1002/anie.202112456
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H01190, KAKENHI-PROJECT-20J11437, KAKENHI-PROJECT-21J15614, KAKENHI-PROJECT-19KK0138, KAKENHI-PROJECT-21H02421, KAKENHI-ORGANIZER-20H05862
[Journal Article] Heme controls the structural rearrangement of its sensor protein mediating the hemolytic bacterial survival2021
- Author(s)
  Nishinaga Megumi、Sugimoto Hiroshi、Nishitani Yudai、Nagai Seina、Nagatoishi Satoru、Muraki Norifumi、Tosha Takehiko、Tsumoto Kouhei、Aono Shigetoshi、Shiro Yoshitsugu、Sawai Hitomi
- Journal Title
  
  Communications Biology
  
  Volume: 4 Issue: 1 Pages: 467-467
- DOI
  10.1038/s42003-021-01987-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-19H05761, KAKENHI-PLANNED-19H05762, KAKENHI-PROJECT-19H00926, KAKENHI-PROJECT-17H03093, KAKENHI-PROJECT-18K05321, KAKENHI-PUBLICLY-20H05451, KAKENHI-PROJECT-21H02064, KAKENHI-PROJECT-21H02421, KAKENHI-PROJECT-20K06517, KAKENHI-PROJECT-21K05281, KAKENHI-PROJECT-20H02531, KAKENHI-PLANNED-19H05766
[Journal Article] XFEL Crystal Structures of Peroxidase Compound II2021
- Author(s)
  Kwon, H., Basran, J., Pathak, C., Hussain, M., Freeman, S. L., Fielding, A. J., Bailey, A. J., Stefanou, N., Sparkes, H. A., Tosha, T., Yamashita, K., Hirata, K., Murakami, H., Ueno, G., Ago, H., Tono, K., Yamamoto, M., Sawai, H., Shiro, Y., Sugimoto, H., Raven, E., Moody, P. C. E.
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: - Issue: 26 Pages: 14578-14585
- DOI
  10.1002/anie.202103010
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-20H05452, KAKENHI-PLANNED-19H05761, KAKENHI-PUBLICLY-20H05451, KAKENHI-PROJECT-19H00926, KAKENHI-PROJECT-21H02064, KAKENHI-PROJECT-21K05281
[Journal Article] Time-resolved studies of metalloproteins using X-ray free electron laser radiation at SACLA2020
- Author(s)
  Suga Michihiro、Shimada Atsuhiro、Akita Fusamichi、Shen Jian-Ren、Tosha Takehiko、Sugimoto Hiroshi
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - General Subjects
  
  Volume: 1864 Issue: 2 Pages: 129466-129466
- DOI
  10.1016/j.bbagen.2019.129466
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22208, KAKENHI-PROJECT-19K22403, KAKENHI-PROJECT-17H03092, KAKENHI-ORGANIZER-17H06433, KAKENHI-PLANNED-17H06434
[Journal Article] Crystals in minutes: instant on-site microcrystallisation of various flavours of the CYP102A1 (P450BM3) haem domain2020
- Author(s)
  Stanfield, J. K., Omura, K., Matsumoto, A., Kasai, C., Sugimoto, H., Shiro, Y., Watanabe, Y., Shoji, O.
- Journal Title
  
  Angew. Chem. Int. Ed.
  
  Volume: 59 Issue: 19 Pages: 7611-7618
- DOI
  10.1002/anie.201913407
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22403, KAKENHI-PLANNED-15H05806, KAKENHI-PROJECT-19J21931
[Journal Article] Serial Femtosecond Zero Dose Crystallography Captures a Water‐Free Distal Heme Site in a Dye‐Decolorising Peroxidase to Reveal a Catalytic Role for an Arginine in Fe IV =O Formation2020
- Author(s)
  Lucic Marina、Svistunenko Dimitri A.、Wilson Michael T.、Chaplin Amanda K.、Davy Bradley、Ebrahim Ali、Axford Danny、Tosha Takehiko、Sugimoto Hiroshi、Owada Shigeki、Dworkowski Florian S. N.、Tews Ivo、Owen Robin L.、Hough Michael A.、Worrall Jonathan A. R.
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 59 Issue: 48 Pages: 21656-21662
- DOI
  10.1002/anie.202008622
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-20H05451, KAKENHI-PROJECT-17H03092, KAKENHI-PROJECT-19K22403
[Journal Article] Dose-resolved serial synchrotron and XFEL structures of radiation sensitive metalloproteins2019
- Author(s)
  Ebrahim, A., Moreno-Chicano, T., Appleby, M. V., Chaplin, A. K., Beale, J. H., Sherrell, D. A., Duyvesteyn, H. M. E., Owada, S., Tono, K., Sugimoto, H., Strange, R. W., Worrall, J. A. R., Axford, D., Owen, R. L., Hough, M. A.
- Journal Title
  
  IUCrJ
  
  Volume: 6 Issue: 4 Pages: 543-543
- DOI
  10.1107/s2052252519003956
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05896, KAKENHI-PROJECT-19K22403
[Journal Article] Chemomechanical Coupling in the Transport Cycle of a Type II ABC Transporter2019
- Author(s)
  K. Tamura, H. Sugimoto, Y. Shiro, Y. Sugita
- Journal Title
  
  J. Phys. Chem. B
  
  Volume: 123 Issue: 34 Pages: 7270-7281
- DOI
  10.1021/acs.jpcb.9b04356
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19H05761, KAKENHI-PROJECT-19H00926, KAKENHI-PROJECT-18H02396
[Journal Article] High-throughput structures of protein-ligand complexes at room temperature using serial femtosecond crystallography2019
- Author(s)
  T. Moreno-Chicano, A. Ebrahim, D. Axford, M. V. Appleby, J. H. Beale, AMoreno-Chicano, T., Ebrahim, A., Axford, D., Appleby, M. V., Beale, J. H., Chaplin, A. K., Duyvesteyn, H. M. E., Ghiladi, R. A., Owada, S., Sherrell, D. A., Strange, R. W., Sugimoto, H., Tono, K., Worrall, J. A. R., Owen, R. L., Hough, M. A.
- Journal Title
  
  IUCrJ
  
  Volume: 6 Issue: 6 Pages: 1074-1074
- DOI
  10.1107/s2052252519011655
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22403
[Journal Article] Hemozoin produced by mammals confers heme tolerance2019
- Author(s)
  Pek, R. H., Yuan, X., Rietzschel, N., Zhang, J., Jackson, L., Nishibori, E., Ribeiro, A., Simmons, W., Jagadeesh, J., Sugimoto, H., Alam, M. Z., Garrett, L., Haldar, M., Ralle, M., Phillips, J. D., Bodine, D. M., Hamza, I.
- Journal Title
  
  eLIFE
  
  Volume: 8
- DOI
  10.7554/elife.49503
- NAID
  120007127793
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02396
[Journal Article] Structure and Molecular Mechanism of the Bacterial Heme Transporter2018
- Author(s)
  杉本宏、城宜嗣
- Journal Title
  
  Seibutsu Butsuri
  
  Volume: 58 Issue: 1 Pages: 022-023
- DOI
  10.2142/biophys.58.022
- NAID
  130006322041
- ISSN
  0582-4052, 1347-4219
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-17H05896
[Journal Article] Structural basis for promotion of duodenal iron absorption by enteric ferric reductase with ascorbate.2018
- Author(s)
  Ganasen M, Togashi H, Takeda H, Asakura H, Tosha T, Yamashita K, Hirata K, Nariai Y, Urano T, Yuan X, Hamza I, Mauk AG, Shiro Y, Sugimoto H, Sawai H.
- Journal Title
  
  Communications Biology
  
  Volume: 1 Issue: 1 Pages: 120-120
- DOI
  10.1038/s42003-018-0121-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08983, KAKENHI-PROJECT-18K05321, KAKENHI-PROJECT-26220807, KAKENHI-PROJECT-17H03092, KAKENHI-PROJECT-18H02396
[Journal Article] Structural Biology of the Bacterial Heme Acquisition and Transport Systems2017
- Author(s)
  杉本宏
- Journal Title
  
  Nihon Kessho Gakkaishi
  
  Volume: 59 Issue: 4 Pages: 166-173
- DOI
  10.5940/jcrsj.59.166
- NAID
  130006032057
- ISSN
  0369-4585, 1884-5576
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-17H05896
[Journal Article] ヘム輸送タンパク質の立体構造2017
- Author(s)
  杉本宏
- Journal Title
  
  感染・炎症・免疫
  
  Volume: 47 Pages: 41-144
- Data Source
  KAKENHI-PUBLICLY-17H05896
[Journal Article] Capturing an initial intermediate during the P450nor enzymatic reaction using time-resolved XFEL crystallography and caged-substrate2017
- Author(s)
  Tosha Takehiko、Kubo Minoru, et. al
- Journal Title
  
  Nature Communications
  
  Volume: 8 Issue: 1 Pages: 1-9
- DOI
  10.1038/s41467-017-01702-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-15H05806, KAKENHI-PUBLICLY-17H05896, KAKENHI-PLANNED-26105012, KAKENHI-PROJECT-26220807, KAKENHI-PROJECT-15H03841, KAKENHI-PROJECT-17H03092, KAKENHI-PROJECT-15H05476, KAKENHI-PROJECT-15K18487
[Journal Article] Structural basis for binding and transfer of heme in bacterial heme-acquisition systems2017
- Author(s)
  Naoe Youichi、Nakamura Nozomi、Rahman Md. Mahfuzur、Tosha Takehiko、Nagatoishi Satoru、Tsumoto Kouhei、Shiro Yoshitsugu、Sugimoto Hiroshi
- Journal Title
  
  Proteins: Structure, Function, and Bioinformatics
  
  Volume: 85 Issue: 12 Pages: 2217-2230
- DOI
  10.1002/prot.25386
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-17H05896, KAKENHI-PROJECT-26220807, KAKENHI-PROJECT-16H02420, KAKENHI-PROJECT-16H04710, KAKENHI-PROJECT-17H03092
[Journal Article] Crystal structure of bacterial haem importer complex in the inward-facing conformation2016
- Author(s)
  Naoe, Y., Nakamura, N., Doi, A., Sawabe, M., Nakamura, H., Shiro, Y., Sugimoto, H.
- Journal Title
  
  Nature Communications
  
  Volume: 7 Issue: 1 Pages: 13411-13411
- DOI
  10.1038/ncomms13411
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01655, KAKENHI-PROJECT-26220807, KAKENHI-PROJECT-26620140
[Journal Article] A Nearly On-axis Spectroscopic System for Simultaneously Measuring UV-visible Absorption and X-ray Diffraction in the SPring-8 Structural Genomics Beamline2016
- Author(s)
  M. Sakaguchi, T. Kimura, T. Nishida, T. Tosha, Y. Yamaguchi, S. Yanagisawa, G. Ueno, H. Murakami, H. Ago, M. Yamamoto, T. Ogura, Y. Shiro, M. Kubo
- Journal Title
  
  J. Synchro. Rad.
  
  Volume: 23 Issue: 1 Pages: 334-338
- DOI
  10.1107/s1600577515018275
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26620140, KAKENHI-PUBLICLY-15H00960, KAKENHI-PUBLICLY-15H00965, KAKENHI-PUBLICLY-15H01055, KAKENHI-PUBLICLY-15H01655, KAKENHI-PUBLICLY-26104532, KAKENHI-PROJECT-26220807, KAKENHI-PROJECT-15H05476, KAKENHI-PUBLICLY-16H00848
[Journal Article] Crystal Structure of Response Regulator ChrA in the Heme-Sensing Two-Component System of Corynebacterium diphtheriae2015
- Author(s)
  A. Doi, H. Nakamura, Y. Shiro, H. Sugimoto
- Journal Title
  
  Acta Crysll. F
  
  Volume: 71 Issue: 8 Pages: 966-971
- DOI
  10.1107/s2053230x15009838
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26620140, KAKENHI-PUBLICLY-15H01655, KAKENHI-PROJECT-26220807, KAKENHI-PROJECT-24687015
[Journal Article] An in vivo Inhibitory Effect on the Heme Uptake of Pseudomonas aeruginosa by Its Hemophore (HasAp) Carrying Synthetic Metal Complexes.2014
- Author(s)
  Shirataki, C.; Shoji, O.; Terada, M.; Ozaki, S.; Sugimoto, H.; Shiro, Y.; Watanabe, Y.
- Journal Title
  
  Angw. Chem. Int. Ed.
  
  Volume: 53 Issue: 11 Pages: 2862-2866
- DOI
  10.1002/anie.201307889
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22105012, KAKENHI-PROJECT-24225004, KAKENHI-PUBLICLY-25105724, KAKENHI-PUBLICLY-25121739, KAKENHI-PROJECT-26708018
[Journal Article] Chiral Substrate Analogues Assisted Stereoselective Epoxidation Catalyzed by H_2O_2-Dependent Cytochrome P450SPa2012
- Author(s)
  T. Fujishiro, O. Shoji, N. Kawakami, T. Watanabe, H. Sugimoto, Y. Shiro, Y. Watanabe
- Journal Title
  
  Chem. Asian J
  
  Volume: 7 Pages: 2286-2293
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21245041
[Journal Article] Chiral Substrate Analogues Assisted Stereoselective Epoxidation Catalyzed by H2O2-Dependent Cytochrome P450SPα2012
- Author(s)
  T. Fujishiro, O. Shoji, N. Kawakami, T. Watanabe, H. Sugimoto, Y. Shiro, Y. Watanabe
- Journal Title
  
  Chem. Asian J.
  
  Volume: 7 Pages: 2286-2293
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21245041
[Journal Article] Diversity and Substrate Specificity in the Structures of Steroidogenic Cytochrome P450 Enzymes2012
- Author(s)
  H. Sugimoto, Y. Shiro
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 35 Pages: 818-823
- NAID
  130001872159
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21245041
[Journal Article] Molecular Structures and Mechanism of Bacterial Nitric Oxide Reductase2012
- Author(s)
  T. Hino, S. Nagano, H. Sugimoto, T. Tosha, Y. Shiro
- Journal Title
  
  Special Issue on Respiratory Oxidases in Biochim
  
  Volume: Biophys. Acta - Bioenergetics 1817 Pages: 680-687
- Data Source
  KAKENHI-PROJECT-21245041
[Journal Article] Molecular Structures and Mechanism of Bacterial Nitric Oxide Reductase2012
- Author(s)
  T. Hino, S. Nagano, H. Sugimoto, T. Tosha, Y. Shiro
- Journal Title
  
  Biochim. Biophys. Acta - Bioenergetics
  
  Volume: 1817 Pages: 680-687
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21245041
[Journal Article] Structural Basis for Nitrous Oxide Generation by Bacterial Nitric Oxide Reductases2012
- Author(s)
  Y. Shiro, H. Sugimoto, T. Tosha, S. Nagano, T. Hino
- Journal Title
  
  Philosophical Transactions B, The Royal Society
  
  Volume: 367 Pages: 1195-1203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21245041
[Journal Article] Crystal Structure of Quinol-Dependent Nitric Oxide Reductase from Geobacillus Stearothermophilus2012
- Author(s)
  Y. Matsumoto, T. Tosha, A. V. Pisliakov, T. Hino, H. Sugimoto, S. Nagano, Y. Sugita, Y. Shiro
- Journal Title
  
  Nat. Strl. Mol. Biol
  
  Volume: 19 Pages: 238-245
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21245041
[Journal Article] Crystal Structure of Quinol-Dependent Nitric Oxide Reductase from Geobacillus stearithermophilus2012
- Author(s)
  Y.Matsumoto, T.Tosha, A.V.Pisliakov, T.Hino, H.Sugimoto, S.Nagano, Y.Sugita, Y.Shiro
- Journal Title
  
  Nat.Strl.Mol.Biol.
  
  Volume: 19 Issue: 2 Pages: 238-245
- DOI
  10.1038/nsmb.2213
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21245041, KAKENHI-PLANNED-22105012, KAKENHI-PROJECT-22310137, KAKENHI-PROJECT-22770136, KAKENHI-PROJECT-22770163, KAKENHI-PUBLICLY-23121531
[Journal Article] Structural basis for the transcriptional regulation of heme homeostasis in Lactococcus lactis2012
- Author(s)
  H. Sawai
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 287 Issue: 36 Pages: 30755-30768
- DOI
  10.1074/jbc.m112.370916
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23350084, KAKENHI-PROJECT-24687015, KAKENHI-PUBLICLY-23121531
[Journal Article] "Structural Basis for Nitrous Oxide Generation by Bacterial Nitric Oxide Reductases" the Proceedings of the Royal Society Meeting2012
- Author(s)
  Y. Shiro, H. Sugimoto, T. Tosha, S. Nagano, T. Hino
- Journal Title
  
  'Nitrous oxide, the forgotten greenhouse gas', Philosophical Transactions B, The Royal Society
  
  Volume: 367 Pages: 1195-1203
- Data Source
  KAKENHI-PROJECT-21245041
[Journal Article] Structural Basis for Oxygen Sensing and Signal Transduction of the Heme-Based Sensor Protein Aer2 from Pseudomonas aeruginosa2012
- Author(s)
  H. Sawai, H. Sugimoto, Y. Shiro, H. Ishikawa, Y. Mizutani, S. Aono
- Journal Title
  
  Chem. Commun
  
  Volume: 48 Issue: 52 Pages: 6523-6525
- DOI
  10.1039/c2cc32549g
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21245041, KAKENHI-PROJECT-23350084, KAKENHI-PROJECT-23651086, KAKENHI-PROJECT-24687015, KAKENHI-PROJECT-24770124, KAKENHI-PLANNED-22105012
[Journal Article] Crystal Structure of H2O2-dependent Cytochrome P450SPαwith its Bound Fatty Acid Substrate : Insight into the Regioselective Hydroxylation of Fatty Acids at theαPosition2011
- Author(s)
  T. Fujishiro, O. Shoji, S. Nagano, H. Sugimoto, Y. Shiro, Y. Watanabe
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 286 Issue: 34 Pages: 29941-29950
- DOI
  10.1074/jbc.m111.245225
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19105004, KAKENHI-PROJECT-21245041, KAKENHI-PROJECT-21685018, KAKENHI-PLANNED-22105012, KAKENHI-PROJECT-22310137, KAKENHI-PUBLICLY-23121531
[Journal Article] Structural Basis for Nitrous Oxide Generation by Bacterial Nitric Oxide Reductases2011
- Author(s)
  Y.Shiro, H.Sugimoto, T.Tosha, S.Nagano, T.Hino
- Journal Title
  
  Philosophical Transactions of the Royal Society B
  
  Volume: 00 Issue: 1593 Pages: 1-9
- DOI
  10.1098/rstb.2011.0310
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770136, KAKENHI-PROJECT-24687015
[Journal Article] Crystal Structure of H_2O_2-dependent Cytochrome P450_<SPa> with Its Bound Fatty Acid Substrate: Insight into the Regioselective Hydroxylation of Fatty Acids at the a Position2011
- Author(s)
  T. Fujishiro, O. Shoji, S. Nagano, H. Sugimoto, Y. Shiro, Y. Watanabe
- Journal Title
  
  J. Biol. Chem
  
  Volume: 286 Pages: 29941-29950
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21245041
[Journal Article] Bioconversion of vitamin D to its active form by bacterial or mammalian cytochrome P4502011
- Author(s)
  Sakaki T, Sugimoto H, Hayashi K, Ikushiro S(他4名)
- Journal Title
  
  Biochem. Biophys. Acta
  
  Volume: 1814 Pages: 249-256
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Resonance Raman study on the oxygenated and the ferryl-oxo species of indoleamine 2,3-dioxygenase during catalytic turnover2011
- Author(s)
  S. Yanagisawa, M. Horitani, H. Sugimoto, Y. Shiro, N. Okada, T. Ogura
- Journal Title
  
  Faraday Discuss
  
  Volume: 1814 Pages: 249-256
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21245041
[Journal Article] Crystal Structure of Carbonmonoxide Complex of Human Cytoglobin2011
- Author(s)
  M. Makino, H. Sawai, Y. Shiro, H. Sugimoto
- Journal Title
  
  PROTEINS
  
  Volume: 79 Pages: 1143-1153
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21245041
[Journal Article] Bioconversion of vitamin D to its active form by bacterial or mammalian cytochrome P4502011
- Author(s)
  Sakaki T, Sugimoto H, Hayashi K, Ikushiro S, 他4名
- Journal Title
  
  Biochem.Biophys.Acta
  
  Volume: 1814 Pages: 249-256
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Design of Novel Hypoxia-targeting IDO Hybrid Inhibitors Conjugated with an Unsubstituted L-TRP as an IDO Affinity Moiety2010
- Author(s)
  H.Nakashima, K.Ikkyu, K.Nakashima, K.Sano, Y.Uto, E.Nakata, H.Nagasawa, H.Sugimoto, Y.Shiro, Y.Nakagawa, H.Hori
- Journal Title
  
  Adv.Exp.Med.Biol.
  
  Volume: 662
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21245041
[Journal Article] Three-step hydroxylation of vitamin D_3 by a genetically engineered CYP 105A12010
- Author(s)
  Hayashi K, Sugimoto H, Kittaka A, Sakaki T, 他6名
- Journal Title
  
  FEBS J
  
  Volume: 277 Pages: 3999-4009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Bioconversion of Vitamin D to Its Active Form by Bacterial or Mammalian Cytochromes P4502010
- Author(s)
  T. Sakaki, H. Sugimoto, K. Hayashi, K. Yasuda, E. Munetsna, M. Kamakura, S. Ikushiro, Y. Shiro
- Journal Title
  
  Biochim. Biophys. Acta
  
  Volume: 1814 Pages: 249-256
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21245041
[Journal Article] ONIOM Study on a Missing Piece in Our Understanding of Heme Chemistry : Bacterial Tryptophan 2,3-Dioxygenase with Dual Oxidants2010
- Author(s)
  L.W.Chung, X.Li, H.Sugimoto, Y.Shiro, K.Morokuma
- Journal Title
  
  J.Am.Chem.Soc.
  
  Volume: 132 Pages: 11993-12005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21245041
[Journal Article] Three-step hydroxylation of vitamin D_3 by a genetically engineered CYP105A12010
- Author(s)
  Hayashi K, Sugimoto H, Kittaka A, Sakaki T(他6名)
- Journal Title
  
  FEBS J
  
  Volume: 277 Pages: 3999-4009
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Structural Basis of Biological N2O Generation by Bacterial Nitric Oxide Reductase2010
- Author(s)
  T. Hino, Y. Matsumoto, S. Nagano, H. Sugimoto, Y. Fukumori, T. Murata, S. Iwata, Y. Shiro
- Journal Title
  
  Science
  
  Volume: 330 Pages: 1666-1670
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21245041
[Journal Article] CYP105A1二重変異体を発現する放線菌を用いた活性型ビタミンD_3の生産2010
- Author(s)
  安田佳織、杉本宏、橘高敦史、榊利之(他6名)
- Journal Title
  
  ビタミン誌
  
  Volume: 82 Pages: 649-661
- NAID
  110008607853
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Design of Novel Hypoxia-targeting IDO Hybrid Inhibitors Conjugated with an Unsubstituted L-TRP as an IDO Affinity Moiety2010
- Author(s)
  H. Nakashima, K. Ikkyu, K. Nakashima, K. Sano, Y. Uto, E. Nakata, H. Nagasawa, H. Sugimoto, Y. Shiro, Y. Nakagawa, H. Hori
- Journal Title
  
  Adv. Exp. Med. Biol
  
  Volume: 662 Pages: 415-421
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21245041
[Journal Article] Structural Basis of Biological N_2O Generation by Bacterial Nitric Oxide Reductase2010
- Author(s)
  T.Hino, Y.Matsumoto, S.Nagano, H.Sugimoto, Y.Fukumori, T.Murata, S.Iwata, Y.Shiro
- Journal Title
  
  Science
  
  Volume: 330 Pages: 1666-1670
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21245041
[Journal Article] A Specific Interaction of L-Tryptophan with CO of CO-Bound Indoleamine 2,3-Dioxygenase Identified by Resonance Raman Spectroscopy2010
- Author(s)
  S. Yanagisawa, H. Sugimoto, Y. Shiro, T. Ogura
- Journal Title
  
  Biochemistry
  
  Volume: 49 Pages: 10081-10088
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21245041
[Journal Article] Three-step Hydroxylations of Vitamin D_3 by a Genetically Engineered CYP105A12010
- Author(s)
  K. Hayashi, K. Yasuda, H. Sugimoto, S. Ikushiro, M. Kamakura, A. Kittaka, R. Horst, T. Chen, M. Ohta, Y. Shiro, T. Sakaki
- Journal Title
  
  FEBS Lett
  
  Volume: 277 Pages: 3999-4009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21245041
[Journal Article] Three-step Hydroxylations of Vitamin D_3 by a Genetically Engineered CYP105A12010
- Author(s)
  K.Hayashi, K.Yasuda, H.Sugimoto, S.Ikushiro, M.Kamakura, A.Kittaka, R.Horst, T.Chen, M.Ohta, Y.Shiro, T.Sakaki
- Journal Title
  
  FEBS Lett.
  
  Volume: 277 Pages: 3999-4009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21245041
[Journal Article] ONIOM Study on a Missing Piece in Our Understanding of Heme Chemistry: Bacterial Tryptophan 2,3-Dioxygenase with Dual Oxidants2010
- Author(s)
  L. W. Chung, X. Li, H. Sugimoto, Y. Shiro, K. Morokuma
- Journal Title
  
  J. Am. Chem. Soc
  
  Volume: 132 Pages: 11993-12005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21245041
[Journal Article] CYP 105A1二重変異体を発現する放線菌を用いた活性型ビタミンD_3の生産2010
- Author(s)
  安田佳織、杉本宏、橘高敦史, 榊利之, 他6名
- Journal Title
  
  ビタミン誌
  
  Volume: 82 Pages: 649-661
- NAID
  110008607853
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Bioconversion of Vitamin D to Its Active Form by Bacterial or Mammalian Cytochromes P4502010
- Author(s)
  T.Sakaki, H.Sugimoto, K.Hayashi, K.Yasuda, E.Munetsna, M.Kamakura, S.Ikushiro, Y.Shiro
- Journal Title
  
  Biochim.Biophys.Acta
  
  Volume: 1814 Pages: 249-256
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21245041
[Journal Article] Cooperative Binding of L-Trp to Human Tryptophan 2,3-Dioxygenase : Resonance Raman Spectroscopic Analysis2009
- Author(s)
  E.Fukumura, H.Sugimoto, Y.Misumi, T.Ogura, Y.Shiro
- Journal Title
  
  J.Biochem.
  
  Volume: 145 Pages: 505-515
- NAID
  10026302198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21245041
[Journal Article] Identification of the Fe-O_2 and the Fe=O Heme Species for Indoleamine 2, 3-Dioxygenase during Catalytic Turnover2009
- Author(s)
  S.Yanagisawa, K.Yotsuya, Y.Hashiwaki, M.Horitani, H.Sugimoto, Y.Shiro, T.Ogura
- Journal Title
  
  Chem.Lett. 39
  
  Pages: 36-37
- NAID
  10027176398
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20050033
[Journal Article] Identification of the Fe-O2 and the Fe=O Heme Species for Indoleamine 2,3-Dioxygenase during Catalytic Turnover2009
- Author(s)
  S.Yanagisawa, K.Yotsuya, Y.Hashiwaki, M.Horitani, H.Sugimoto, Y.Shiro, E.H.Appelman, T.Ogura
- Journal Title
  
  Chem.Lett.
  
  Volume: 39 Pages: 36-37
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21245041
[Journal Article] Cooperative binding of L-trp to human tryptophan 2,3-dioxygenase : resonance Raman spectroscopic analysis.2009
- Author(s)
  Fukumura, E., Sugimoto, H., Misumi, Y., Ogura, T., Shiro, Y.
- Journal Title
  
  J. Biochem. 145
  
  Pages: 505-515
- NAID
  10026302198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770094
[Journal Article] Cooperative Binding of L-Trp to Human Tryptopahn 2, 3-Dioxygenase : Resonanace Raman Spectroscopic Analysis2009
- Author(s)
  E.Fukumura, H.Sugimoto, Y.Misumi, T.Ogura.Y.Shiro
- Journal Title
  
  J.Biochem. (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20050033
[Journal Article] X-ray Crystal Structure of the Michaelis Complex of Aldoxime Dehydratase2009
- Author(s)
  H.Sawai, H.Sugimoto, Y.Kato, Y.Asano, Y.Shiro, S.Aono
- Journal Title
  
  J.Biol.Chem. 284
  
  Pages: 32089-32096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20050033
[Journal Article] X-ray Crystal Structure of the Michaelis Complex of Aldoxime Dehydratase2009
- Author(s)
  H.Sawai, H.Sugimoto, Y.Kato, Y.Asano, Y.Shiro, S.Aono
- Journal Title
  
  J.Biol.Chem.
  
  Volume: 284 Pages: 32089-32096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21245041
[Journal Article] Identification of the Fe-O_2 and the Fe=O Heme Species for Indoleamine 2, 3-Dioxygenase during Catalytic Turnover2009
- Author(s)
  Yanagisawa, S., Yotsuya, K.Sugimoto, H, 他5名
- Journal Title
  
  Chemistry Letters 39
  
  Pages: 36-37
- NAID
  10027176398
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380067
[Journal Article] Cooperative Binding of L-Trp to Human Tryptophan 2,3-Dioxygenase : Resonance Raman Spectroscopic Analysis2009
- Author(s)
  E.Fukumura, H.Sugimoto, Y.Misumi, T.Ogura, Y.Shiro
- Journal Title
  
  J.Biochem. 145
  
  Pages: 505-515
- NAID
  10026302198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20050033
[Journal Article] X-ray Crystal Structure of the Michaelis Complex of Aldoxime Dehydratase2009
- Author(s)
  H. Sawai, H. Sugimoto, Y. Kato, Y. Asano, Y. Shiro, S. Aono
- Journal Title
  
  J. Biol. Chem
  
  Volume: 284 Pages: 32089-32096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21245041
[Journal Article] Structure of PAS-linked Histidine Kinase and the Response Regulator Complex2009
- Author(s)
  S.Yamada, H.Sugimoto, M.Kobayashi, A.Ohno, H.Nakamura, Y.Shiro
- Journal Title
  
  Structure 17
  
  Pages: 1333-1344
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20050033
[Journal Article] Identification of the Fe-O_2 and the Fe=O Heme Species for Indoleamine 2,3-Dioxygenase during Catalytic Turnover2009
- Author(s)
  S. Yanagisawa, K. Yotsuya, Y. Hashiwaki, M. Horitani, H. Sugimoto, Y. Shiro, E. H. Appelman, T. Ogura
- Journal Title
  
  Chem. Lett
  
  Volume: 39 Pages: 36-37
- NAID
  10027176398
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21245041
[Journal Article] Structure of PAS-linked Histidine Kinase and the Response Regulator Complex2009
- Author(s)
  S. Yamada, H. Sugimoto, M. Kobayashi, A. Ohno, H. Nakamura, Y. Shiro
- Journal Title
  
  Structure
  
  Volume: 17 Pages: 1333-1344
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21245041
[Journal Article] Cooperative Binding of L-Trp to Human Tryptophan 2,3-Dioxygenase: Resonance Raman Spectroscopic Analysis2009
- Author(s)
  E. Fukumura, H. Sugimoto, Y. Misumi, T. Ogura, Y. Shiro
- Journal Title
  
  J. Biochem
  
  Volume: 145 Pages: 505-515
- NAID
  10026302198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21245041
[Journal Article] Crystal Structure of CYP105A1(P450SU-1) in Complex with 1a, 25-dihydroxyvitamin D_32008
- Author(s)
  H.Sugimoto, R.Shinkyo, K.Hayashi, S.Yoneda, M.Yamada, M.Kamakura, S, Ikushiro, Y.Shiro, T.Sakaki
- Journal Title
  
  Biochemistry 47
  
  Pages: 4017-4027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20050033
[Journal Article] Structure-based design of a highly active vitamin D hydroxylase from Streptomyces griseolus CYP105A1.2008
- Author(s)
  Hayashi, K., Sugimoto, H., Shinkyo, R., Yamada, M., Ikeda, S., Ikushiro, S., Kamakura, M., Shiro, Y., Sakaki, T.
- Journal Title
  
  Biochemistry 47
  
  Pages: 11964-11972
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770094
[Journal Article] Synthesis and Biological Activity of 1-methyl-tryptophan-tirapazamine Hybrids hypoxia-targeting Indoleamine 2, 3-dioxygenase inhibitors2008
- Author(s)
  H.Nakashima, Y.Uto, E.Nakata, H.Nagasawa, K.Ikkyu, N.Hiraoka, K.Nakashima, Y.Sasaki, H.Sugimoto, Y.Shiro, T.hashimoto, Y.Okamoto, Y.Asakawa, H.Hori :
- Journal Title
  
  Bioorg.Med.Chem. 16
  
  Pages: 8661-8669
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20050033
[Journal Article] Density functional theory study on a missing piece in understanding of heme chemistry : the reaction mechanism for indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase.2008
- Author(s)
  Chung, L. W., Li, X., Sugimoto, H., Shiro, Y., Morokuma, K.
- Journal Title
  
  J. Am. Chem. Soc. 130
  
  Pages: 12299-12309
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770094
[Journal Article] Crystal structure of CYP105A1 (P450SU-1) in complex with 1alpha,25-dihydroxyvitamin D_3.2008
- Author(s)
  Sugimoto, H., Shinkyo, R., Hayashi, K., Yoneda, S., Yamada, M., Kamakura, M., Ikushiro, S., Shiro, Y., Sakaki, T.
- Journal Title
  
  Biochemistry 47
  
  Pages: 4017-4027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770094
[Journal Article] Density Functional Theory Study on a MIssing Piece in Understanding of Heme Chemistry : The Reaction Mechanism Fro Indoleamine 2, 3-dioxygenase and Typtophan 2, 3-dioxygenase2008
- Author(s)
  L.W.Chung, X.Li, H.Sugimoto, Y.Shiro, K.Morokuma
- Journal Title
  
  J.Am.Chem.Soc. 130
  
  Pages: 12299-12309
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20050033
[Journal Article] Synthesis and biological activity of 1-methyl-tryptophan-tirapazamine hybrids as hypoxia-targeting indoleamine 2,3-dioxygenase inhibitors.2008
- Author(s)
  Nakashima, H., Uto, Y., Nakata, E., Nagasawa, H., Ikkyu, K., Hiraoka, N., Nakashima, K., Sasaki, Y., Sugimoto, H., Shiro, Y., Hashimoto, T., Okamoto, Y., Asakawa, Y., Hori, H.
- Journal Title
  
  Bioorg. Med. Chem. 16
  
  Pages: 8661-8669
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770094
[Journal Article] Sturucture-based Design of a Highly Active Vitamin D Hydroxylase from Streptomyces griseolus CYP105A12008
- Author(s)
  K.Hayashi, H.Sugimoto, R.Shinkyo, M.Yamada, S.Ikeda, S.Ikushiro, M.Kamakura, Y.Shiro, T.sasaki
- Journal Title
  
  Biochemistry 47
  
  Pages: 11964-11972
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20050033
[Journal Article] Crystal Structures and Catalytic Mechanism of Cytochrome P450 StaP That Produces The Indolocarbazole Skeleton2007
- Author(s)
  H. Makino, H. Sugimoto, Y. Shiro, S. Asamizu, H. Onaka, S. Nagano
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 104
  
  Pages: 11591-11596
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16074217
[Journal Article] Crystal Structures and Catalytic Mechanism of Cytochrome P450 StaP That Produces The Indolocarbazole Skeleton2007
- Author(s)
  M. Makino, H. Sugimoto, Y. Shiro, S. Asamizu, H. Onaka, S. Nagano
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 104
  
  Pages: 11591-11596
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16074217
[Journal Article] The Signaling Pathway in Histidine Kinase and the Response Regulator Complex Revealed by X-ray Crystallography and Solution Scattering2006
- Author(s)
  S.Yamada, S.Akiyama, H.Sugimoto, H.Kumita, K.Ito, T.Fujisawa, H.Nakamura, Y.Shiro
- Journal Title
  
  J. Mol. Biol. 362
  
  Pages: 123-139
- Data Source
  KAKENHI-PROJECT-16074217
[Journal Article] Crystallization and Preliminary Crystallographic Studies of Human Indoleamine 2, 3-Dioxygenase2006
- Author(s)
  S.Oda, H.Sugimoto, T.Yoshida, Y.Shiro
- Journal Title
  
  Acta Cryst. F62
  
  Pages: 221-223
- Data Source
  KAKENHI-PROJECT-16074217
[Journal Article] The Signaling Pathway in Histidine Kinase and the Response Regulator Complex Revealed by X-ray Crystallography and Solution Scattering2006
- Author(s)
  S. Yamada, S. Akiyama, H. Sugimoto, H. Kumita, K. Ito, T. Fujisawa, H. Nakamura, Y. Shiro
- Journal Title
  
  J. Mol. Biol. 362
  
  Pages: 123-139
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16074217
[Journal Article] Crystal Structure of Human Indoleamine 2, 3-dioxygenase : Insight into the Catalytic Mechanism of O_2 Incorporation by a Heme-containing Dioxygenase2006
- Author(s)
  H.Sugimoto, S.Oda, T.Otsuki, T.Hino, T.Yoshida, Y.Shiro
- Journal Title
  
  Poc. Natl. Acd. Sci. USA 103
  
  Pages: 2611-2616
- Data Source
  KAKENHI-PROJECT-16074217
[Journal Article] Crystal Structure of Human Indoleamine 2,3-dioxygenase : Insight into the Catalytic Mechanism of O_2 Incorporation by a Heme-containing Dioxygenase2006
- Author(s)
  H.Sugimoto, S.Oda, T.Otsuki, T.Hino, T.Yoshida, Y.Shiro
- Journal Title
  
  Poc.Natl.Acd.Sci.USA 103
  
  Pages: 2611-2616
- Data Source
  KAKENHI-PROJECT-16074217
[Journal Article] The Signaling Pathway in Histidine Kinase and the Response Regulator Complex Revealed by X-ray Crystallography and Solution Scattering2006
- Author(s)
  S. Yamada, S. Akiyama, H. Sugimoto, H. Kumita. K. Ito, T Fujisawa, H. Nakamura, Y. Shiro
- Journal Title
  
  J. Mol. Biol. 362
  
  Pages: 123-139
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16074217
[Journal Article] High-resolution Structure of Human Cytoglobin : Identification of Extra N- and C-termini and a New Dimerization Mode2006
- Author(s)
  M.Makino, H.Sugimoto, H.Sawai, N.Kawada, K.Yoshizato, Y.Shiro
- Journal Title
  
  Acta Cryst. D62
  
  Pages: 671-677
- Data Source
  KAKENHI-PROJECT-16074217
[Journal Article] Crystal Structure of Human Indoleamine 2, 3-dioxygenase : Insight into the Catalytic Mechanism of 02 Incorporation by a Heme-containing Dioxygenase2006
- Author(s)
  H. Sugimoto, S. Oda, T. Otsuki, T. HIno, T. Yoshida, Y. Shiro
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 103
  
  Pages: 2611-2616
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16074217
[Journal Article] 酸素添加酵素の分子メカニズム2006
- Author(s)
  杉本宏, 永野真吾, 城宜嗣
- Journal Title
  
  日本結晶学会誌 48
  
  Pages: 418-423
- NAID
  10018467419
- Data Source
  KAKENHI-PROJECT-16074217
[Journal Article] Crystal Structure of Human Indoleamine 2, 3-dioxygenase : Insight into the Catalytic Mechanism of 02 Incorporation by a Heme-containing Dioxygenase2006
- Author(s)
  H. Sugimoto, S. Oda, T. Otsuki, T. Hino, T. Yoshida, Y. Shiro
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 103
  
  Pages: 2611-2616
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16074217
[Journal Article] Structural Characterization of the Proximal and Distal Histidine Environment of Cytoglobin and Neuroglobin2005
- Author(s)
  H.Sawai, M.Makino, Y.Mizutani, T.Ohta, H.Sugimoto, T.Uno, N.Kawada, K.Yoshizato, T.Kitagawa, Y.Shiro
- Journal Title
  
  Biochemistry 44
  
  Pages: 13257-13265
- Data Source
  KAKENHI-PROJECT-16074217
[Journal Article] Structural Basis of Human Cytoglobin for Ligand Binding2004
- Author(s)
  H.Sugimoto, et al.
- Journal Title
  
  J.Mol.Biol. 339
  
  Pages: 873-885
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14580616
[Journal Article] Structural Basis of Human Cytoglobin for Ligand Binding2004
- Author(s)
  H.Sugimoto, M.Makino, H.Sawai, N.Kawada, K.Yoshizato, Y.Shiro
- Journal Title
  
  J.Mol.Biol. 339
  
  Pages: 873-885
- Data Source
  KAKENHI-PROJECT-16074217
[Journal Article] Structural basis of human cytoglobin for ligand binding.2004
- Author(s)
  Sugimoto, H., Makino, M., Sawai, H., Kawada, N., Yoshizato, K., Shiro, Y.
- Journal Title
  
  Journal of Molecular Biology 339
  
  Pages: 873-885
- Data Source
  KAKENHI-PROJECT-14780481
[Journal Article] Structural Basis of Human Cytoglobin for Ligand Binding2004
- Author(s)
  H.Sugimoto, M.Makino, H.Sawai, N.Kawada, K.Yoshizato, Y.Shiro
- Journal Title
  
  J.Mol.Biol. 339
  
  Pages: 873-885
- Data Source
  KAKENHI-PROJECT-14580616
[Journal Article] Structural basis for nitrous oxide generation by bacterial nitric oxide reductases
- Author(s)
  Yoshitsugu Shiro, Hiroshi Sugimoto, Takehiko Tosha, Singo Nagano, Tomoya Hino
- Journal Title
  
  Philosophical Transactions of Royal Society B
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23121531
[Journal Article] Crystal structure of CYP105A1 (P450SU-1) in complex with 1□lpha, 25-dihydroxyvitamin D3
- Author(s)
  Hiroshi Sugimoto
- Journal Title
  
  Biochemistry In press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770094
[Presentation] クライオ電子顕微鏡を用いた病原菌ヘムトランスポーターの構造解析2023
- Author(s)
  片岡万知華、阿部綾萌、Chai Gopalasingam、Christoph Gerle、山本雅貴、重松秀樹、杉本宏
- Organizer
  第2回生命金属科学シンポジウム
- Data Source
  KAKENHI-PROJECT-21H02421
[Presentation] クライオ電子顕微鏡を用いた病原菌ヘムトランスポーターの構造解析2023
- Author(s)
  片岡万知華、阿部綾萌、Chai Gopalasingam、Christoph Gerle、城宜嗣、山本雅貴、重松秀樹、杉本宏
- Organizer
  第49回生体分子科学討論会
- Data Source
  KAKENHI-PROJECT-21H02421
[Presentation] Elucidation of Characteristic Cold-Adaptation Mechanism of Pyruvate Kinase from Psychrophilic Bacteria by X-ray Crystallography2023
- Author(s)
  Ekanayake Hansani, Hiroshi Sugimoto,Masaki Horitani
- Organizer
  日本農芸化学会西日本支部第6回学生フォーラム（JSBBA WEST 6th Studendt Forum）
- Data Source
  KAKENHI-PROJECT-23K26836
[Presentation] X線・電子常磁性共鳴法で観る複核Mn中心金属酵素の構造柔軟性と活性相関2023
- Author(s)
  嘉数　百合,坂本　貫太朗, 杉本　宏,堀谷　正樹
- Organizer
  第23回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-23K26836
[Presentation] クライオ電子顕微鏡による病原菌由来ヘムトランスポーターの構造解析2023
- Author(s)
  片岡万知華、阿部綾萌、Chai Goparsingam, Christoph Gerle、城宜嗣、山本雅貴、重松秀樹、杉本宏
- Organizer
  第23回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-21H02421
[Presentation] 酵素は熱安定性を下げずに低温適応できるか？～X線結晶構造解析・EPR法で観る南極産好冷細菌由来金属酵素～2023
- Author(s)
  堀谷　正樹,嘉数　百合, 杉本　宏
- Organizer
  極限環境生物学会第24回年会
- Data Source
  KAKENHI-PROJECT-23K26836
[Presentation] Dynamics of hydrogen atom revealed by ultra-high resolution structure of the heme acquisition protein2023
- Author(s)
  Hiroshi Sugimoto
- Organizer
  Time-Resolved Crystallography Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02421
[Presentation] ABC 型ヘムトランスポーターの構造解析2023
- Author(s)
  片岡万知華、阿部綾萌、Chai Gopalasingam、Christoph Gerle、山本雅貴、重松秀樹、杉本宏
- Organizer
  生命金属科学夏の合宿セミナー
- Data Source
  KAKENHI-PROJECT-21H02421
[Presentation] Elucidation of Characteristic Cold-Adaptation Mechanism of Pyruvate Kinase from Psychrophilic Bacteria by X-ray Crystallography2023
- Author(s)
  Hansani Ekanakyake, Hiroshi Sugimoto,Masaki Horitani
- Organizer
  2nd Japan-India Science & Technology Seminar
- Data Source
  KAKENHI-PROJECT-23K26836
[Presentation] 中性子・XFEL・シンクロトロン結晶学を駆使したヘムタンパク質の精密構造解析2022
- Author(s)
  杉本宏
- Organizer
  第31回iBIX研究会オンライン
- Invited
- Data Source
  KAKENHI-PROJECT-21H02421
[Presentation] 時間分解分光測定を用いたABCトランスポーターBhuUV-Tにおけるヘム輸送機構の解析2022
- Author(s)
  原明穂、城宜嗣、杉本宏、木村哲就
- Organizer
  第60回生物物理学会年会
- Data Source
  KAKENHI-PROJECT-21H02421
[Presentation] 二重スピンラベル-ESR分光法によるABCトランスポーターの膜貫通ドメインのコンフォメーション変化2022
- Author(s)
  仲絢香、小堀康博、鍔木基成、城宜嗣、杉本宏、木村哲就
- Organizer
  第60回生物物理学会年会
- Data Source
  KAKENHI-PROJECT-21H02421
[Presentation] 二重スピンラベルESR 分光法を用いたABC トランスポーターBhuUV-Tの構造解析2022
- Author(s)
  仲絢香、小堀康博、鍔木基成、城宜嗣、杉本宏、木村哲就
- Organizer
  第48回生体分子科学討論会
- Data Source
  KAKENHI-PROJECT-21H02421
[Presentation] High-resolution structural analysis of the heme proteins using neutron and XFEL crystallography2022
- Author(s)
  Hiroshi Sugimoto
- Organizer
  The International Symposium of Quantum Beam Science at Ibaraki University
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02421
[Presentation] 二重スピンラベルESR分光法を用いたABCトランスポーターBhuUV-TのATP結合状態の解析2022
- Author(s)
  仲絢香、小堀康博、城宜嗣、杉本宏、木村哲就
- Organizer
  第22回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-21H02421
[Presentation] Hydrogen atoms in protein structure: high resolution analysis of heme enzymes2022
- Author(s)
  Hiroshi Sugimoto
- Organizer
  SACLA User’s Meeting (Online, Sayo)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-20H05452
[Presentation] 病原菌ヘムABCトランスポーターのクライオ電子顕微鏡解析2022
- Author(s)
  片岡万知華、阿部綾萌、Gopalashingam Chai、Gerle Christoph、城宜嗣、山本雅貴、重松秀樹、杉本宏
- Organizer
  第60回生物物理学会年会
- Data Source
  KAKENHI-PROJECT-21H02421
[Presentation] ABC トランスポーターBhuUV-Tのヘム輸送機構に関する時間分解分光測定2022
- Author(s)
  原明穂、城宜嗣、杉本宏、木村哲就
- Organizer
  第22回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-21H02421
[Presentation] ABC トランスポーターBhuUV-T におけるヘム輸送機構の分光学的解析2022
- Author(s)
  原明穂、城宜嗣、杉本宏、木村哲就
- Organizer
  第48回生体分子科学討論会
- Data Source
  KAKENHI-PROJECT-21H02421
[Presentation] X-ray and Cryo-EM structures of bacterial heme ABC transporter BhuUV-T2022
- Author(s)
  Hiroshi Sugimoto
- Organizer
  10th Asian Biological Inorganic Chemistry Conference (AsBIC10)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02421
[Presentation] High-resolution structural analysis of the heme proteins using neutron and XFEL crystallography2022
- Author(s)
  Hiroshi Sugimoto
- Organizer
  6th International Symposium of Quantum Beam Science at Ibaraki University (Online, Ibaraki)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-20H05452
[Presentation] Kinetic Analysis of Allocrite Transport Mechanism by Spectroscopic Measurements in Heme ABC Transporter BhuUV-T2022
- Author(s)
  Akiho Hara, Yoshitsugu Shiro, Hiroshi Sugimoto, Tetsunari Kimura
- Organizer
  10th Asian Biological Inorganic Chemistry Conference (AsBIC-10)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02421
[Presentation] Conformational Changes in Heme ABC Transporter; BhuUV-T, Investigated by Double Spin-Label ESR Spectroscopy2022
- Author(s)
  Ayaka Naka, Yasuhiro Kobori, Motonari Tsubaki, Yoshitsugu Shiro, Hiroshi Sugimoto, Tetsunari Kimura
- Organizer
  10th Asian Biological Inorganic Chemistry Conference (AsBIC-10)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02421
[Presentation] クライオ電子顕微鏡を用いた病原菌ヘムトランスポーターの構造解析2022
- Author(s)
  片岡万知華、阿部綾萌、Chai Gopalasingam、Christoph Gerle、城宜嗣、山本雅貴、重松秀樹、杉本宏
- Organizer
  第48回生体分子科学討論会
- Data Source
  KAKENHI-PROJECT-21H02421
[Presentation] ヘムABCトランスポーターの基質輸送機構に関する分光学的解析2021
- Author(s)
  木村哲就, 浅田拓也, 仲絢香, 林沙, 城宜嗣, 杉本宏
- Organizer
  第47回生体分子科学討論会
- Data Source
  KAKENHI-PROJECT-21H02421
[Presentation] ヘムの毒性回避のための細胞内結晶の生成とX線粉末回析測定2021
- Author(s)
  杉本宏、西堀英治、Rini H. Pek、Xiaojing Yuan、Iqbal Hamza
- Organizer
  2021年度日本結晶学会年会
- Data Source
  KAKENHI-PROJECT-21H02421
[Presentation] ナノディスク再構成型BhuUV-Tによる段階的な基質輸送の分光学的観察2021
- Author(s)
  木村哲就, 浅田拓也, 林沙英, 鍔木基成, 城宜嗣, 杉本宏
- Organizer
  第21回蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-21H02421
[Presentation] ナノディスク再構成型BhuUV-Tによる段階的な基質輸送の分光学的観察2021
- Author(s)
  木村哲就、浅田拓也、林沙英、鍔木基成、城宜嗣、杉本宏
- Organizer
  第21回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-21H02421
[Presentation] Structural analyses of ABC transporters in nucleotide bound states investigated by CW-ESR spectroscopy2021
- Author(s)
  仲絢香、小堀康博、鍔木基成、城宜嗣、杉本宏、木村哲就
- Organizer
  第59回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-21H02421
[Presentation] Structure and dynamics of proteins involved in bacterial heme transport2021
- Author(s)
  Hiroshi Sugimoto
- Organizer
  International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2021)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02421
[Presentation] 病原菌のヘム獲得のメカニズム2020
- Author(s)
  杉本宏
- Organizer
  第１５回トランスポーター研究会年会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02396
[Presentation] Reconstitution of full-complex of bacterial heme transporter into the platforms suitable for structural analysis2020
- Author(s)
  Ayaho Abe, Hideki Shigematsu, Masaki Yamamoto, Yoshistugu Shiro, Hiroshi Sugimoto
- Organizer
  日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-18H02396
[Presentation] Structural basis of ascorbate-dependent iron reduction by human Dcytb involved in intestinal iron absorption2019
- Author(s)
  Hiroshi Sugimoto, Menega Ganasen, Hiromi Togashi, Hanae Takeda, Yoshitsugu Shiro, A Grant Mauk, Hitomi Sawai
- Organizer
  32nd European Crystallographic Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02396
[Presentation] Structural basis of iron reduction by human duodenal cytochrome b (Dcytb) involved in intestinal iron absorption2019
- Author(s)
  Hiroshi Sugimoto, Menega Ganasen, Hiromi Togashi, Hanae Takeda, Yoshitsugu Shiro, A Grant Mauk, Hitomi Sawai
- Organizer
  19th International Conference on Biological Inorganic Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02396
[Presentation] Understanding the Mechanism of Dietary Iron Absorption at the Atomic level2018
- Author(s)
  M. Ganasen, H. Asakura, T. Tosha, T. Urano, X. Yuan, I. Hamza, A. G. Mauk, Y. Shiro, H. Sugimoto, H. Sawai
- Organizer
  第91回日本生化学会年会
- Data Source
  KAKENHI-PROJECT-18H02396
[Presentation] Computational Modeling of the Outward-facing Form and the Occluded Intermediate of a Heme Importer with Bound Nucleotides2018
- Author(s)
  K. Tamura, H. Sugimoto, Y. Shiro, and Y. Sugita
- Organizer
  256th American Chemical Society National Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05896
[Presentation] Structural basis of ascorbate-dependent iron reduction by human duodenal cytochrome b (Dcytb) involved in intestinal iron absorption2018
- Author(s)
  H. Sugimoto, M. Ganesen, H. Togashi, H. Takeda, H. Asakura, T. Tosha, K. Yamashita, K. Hirata, X. Yuan, I. Hamza, A. G. Mauk, Y. Shiro, H. Sawai
- Organizer
  Asian Crystallographic Association Conference (AsCA 2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02396
[Presentation] Structural basis of the ABC heme transporter in iron uptake system of pathogenic bacteria2018
- Author(s)
  H. Sugimoto
- Organizer
  7th FEBS Special Meeting on ABC Proteins
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05896
[Presentation] 小腸上皮細胞膜で機能する鉄還元酵素Dcytbの結晶構造2018
- Author(s)
  杉本宏, Menega Ganasen 冨樫ひろ美，武田英恵, 朝倉帆南, 山下恵太郎，平田邦生， A. Grant Mauk，城宜嗣，澤井仁美
- Organizer
  平成30年度内外環境応答・代謝酵素研究会
- Data Source
  KAKENHI-PROJECT-18H02396
[Presentation] 分子シミュレーションによるヘムインポーターの化学-力学共役機構の解明2018
- Author(s)
  田村康一 , 杉本宏 , 城宜嗣 , 杉田有治
- Organizer
  第56回日本生物物理学会年会
- Data Source
  KAKENHI-PUBLICLY-17H05896
[Presentation] Structure-guided Functional Analysis of Human Ferric Reductase Using Living Cells2018
- Author(s)
  Menega Ganasen, Hitomi Fujishiro, Xiaojing Yuan, Iqbal Hamza, A. Grant Mauk, Seiichiro Himeno, Hiroshi Sugimoto, Yoshitsugu Shiro, Hitomi Sawai
- Organizer
  Gordon Research Conference: 2018 Chemistry and Biology of Tetrapyrroles
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02396
[Presentation] Structural Insight into the Dietary Non-heme Iron Absorption in Human Duodenum2018
- Author(s)
  M. Ganasen, H. Asakura, T. Tosha, X. Yuan, I. Hamza, A. G. Mauk, Y. Shiro, H. Sugimoto and H. Sawai
- Organizer
  第18回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-18H02396
[Presentation] ヒトの鉄イオン吸収に関わる膜タンパク質の立体構造に基づく生きた細胞での機能解析2018
- Author(s)
  M. Ganasen, 藤代瞳、X. Yuan, I. Hamza, 姫野誠一郎、A. G. Mauk, 杉本宏、城宜嗣、澤井仁美
- Organizer
  メタルバイオサイエンス研究会2018
- Data Source
  KAKENHI-PROJECT-18H02396
[Presentation] Structure analysis of radiation-sensitive NO-bound state of cytochrome P450nor using XFEL at SACLA2018
- Author(s)
  H. Sugimoto
- Organizer
  10th International workshop on X-ray radiation damage to biological samples
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05896
[Presentation] ヒト小腸の細胞膜でDcytbが鉄分吸収を促進するメカニズム2018
- Author(s)
  Menega Ganasen、冨樫ひろ美、山下恵太郎、平田邦生、Grant A. Mauk、城宜嗣、澤井仁美、杉本宏
- Organizer
  平成30年度結晶学会年会
- Data Source
  KAKENHI-PROJECT-18H02396
[Presentation] マイクロ流路ミキサーを用いた時間分解分光測定によるABCトランスポーターの輸送機構解析2017
- Author(s)
  木村哲就、林沙英、大西萌、杉本宏、城宜嗣、小堀康弘、池本夕佳
- Organizer
  第17回日本蛋白質科学会年会
- Place of Presentation
  仙台国際センター（仙台市）
- Year and Date
  2017-06-20
- Data Source
  KAKENHI-PROJECT-15H05476
[Presentation] ABCトランスポーターの分子機構解明を目指した時間分解測定法の開発2017
- Author(s)
  木村哲就, 林沙英, 大西萌, 城宜嗣, 杉本宏, 小堀康弘, 池本夕佳
- Organizer
  第44回生体分子科学討論会
- Data Source
  KAKENHI-PROJECT-15H05476
[Presentation] 病原菌のヘム輸送タンパク質の立体構造と機能2017
- Author(s)
  杉本宏
- Organizer
  第41回日本鉄バイオサイエンス学会学術集会
- Invited
- Data Source
  KAKENHI-PUBLICLY-17H05896
[Presentation] 可視吸収分光測定によるヘムABCトランスポーター; BhuUVの輸送メカニズム解析2017
- Author(s)
  林沙英, 城宜嗣, 杉本宏, 木村哲就
- Organizer
  第44回体分子科学討論会
- Data Source
  KAKENHI-PROJECT-15H05476
[Presentation] Structural basis of the ABC heme transporter in iron uptake system of pathogenic bacteria2017
- Author(s)
  Hiroshi Sugimoto
- Organizer
  7th FEBS Special Meeting on ABC Proteins - ABC2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05896
[Presentation] 時間分解可視吸収分光測定によるヘムABCトランスポーターの輸送メカニズム解析2017
- Author(s)
  林沙英、城宜嗣、杉本宏、木村哲就
- Organizer
  第17回日本蛋白質科学会年会
- Place of Presentation
  仙台国際センター（仙台市）
- Year and Date
  2017-06-20
- Data Source
  KAKENHI-PROJECT-15H05476
[Presentation] 結晶構造から明らかになった病原菌ヘムトランスポーターの分子メカニズム2017
- Author(s)
  杉本宏
- Organizer
  第17回日本蛋白質科学会年会ワークショップ：生体内の金属動態
- Invited
- Data Source
  KAKENHI-PUBLICLY-17H05896
[Presentation] 時間分解可視吸収分光測定によるヘム ABC トランスポーターの輸送メカニズム解析2017
- Author(s)
  林沙英, 城宜嗣, 杉本宏, 木村哲就
- Organizer
  第17回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-15H05476
[Presentation] 可視吸収分光測定によるヘムABCトランスポーター; BhuUVの輸送メカニズム解析2017
- Author(s)
  林沙英, 城宜嗣, 杉本宏, 木村哲就
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-15H05476
[Presentation] マイクロ流路ミキサーを用いた時間分解分光測定による ABC トランスポーターの分子機構解析2017
- Author(s)
  木村哲就, 林沙英, 大西萌, 城宜嗣, 杉本宏, 池本夕佳
- Organizer
  第17回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-15H05476
[Presentation] ABCトランスポーターの分子機構解明を目指した時間分解測定法の開発2017
- Author(s)
  木村哲就、林沙英、大西萌、杉本宏、城宜嗣、小堀康弘、池本夕佳
- Organizer
  第43回生体分子科学討論会
- Place of Presentation
  カレッジプラザ & IYATAKA（秋田市）
- Year and Date
  2017-06-23
- Data Source
  KAKENHI-PROJECT-15H05476
[Presentation] Diverse mechanism of the heme-recognition in the bacterial heme import system2016
- Author(s)
  Hiroshi Sugimoto
- Organizer
  RIKEN SPring-8 Center/University of Hyogo/University of Liverpool Mini-Symposium
- Place of Presentation
  SPring-8上坪ホール（兵庫県・佐用郡）
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01655
[Presentation] Structural and functional analysis of a periplasmic heme-binding protein in bacterial heme importer system2016
- Author(s)
  Md. Mahfuzur Rahman, Nozomi Nakamura, Hiro Nakamura, Hiroshi Sugimoto, Yoshitsugu Shiro
- Organizer
  The 16th annual meeting of the Protein Science Society of Japan
- Place of Presentation
  福岡国際会議場（福岡県・福岡市）
- Year and Date
  2016-06-07
- Data Source
  KAKENHI-PUBLICLY-15H01655
[Presentation] Structure of bacterial heme importer in complex with the periplasmic heme-binding protein2016
- Author(s)
  Hiroshi Sugimoto
- Organizer
  Mini-Symposium on Structure-Based Bioenergetics
- Place of Presentation
  SPring-8上坪ホール（兵庫県・佐用郡）
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01655
[Presentation] Structural basis of the heme recognition by bacterial heme transporter2015
- Author(s)
  Nozomi Nakamura, Youichi Naoe, Akihiro Doi, Hiro Nakamura, Hiroshi Sugimoto, Yoshitsugu Shiro
- Organizer
  Metals in Biology in Wako
- Place of Presentation
  埼玉県和光市理化学研究所
- Year and Date
  2015-06-16
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01655
[Presentation] 結晶構造に基づく病原菌由来ヘムトランスポーターの基質輸送機構の解明2015
- Author(s)
  中村希，直江洋一，土井章弘，杉本宏，城宜嗣
- Organizer
  平成27年度日本結晶学会年会
- Place of Presentation
  大阪府堺市大阪府立大学
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PUBLICLY-15H01655
[Presentation] ヒトの鉄吸収に関与する膜タンパク質Dcytbの結晶化と鉄還元反応に関する研究2015
- Author(s)
  冨樫ひろ美, 武田英恵, 杉本宏, G. Mauk, 城宜嗣
- Organizer
  第15回日本蛋白質科学会年会
- Place of Presentation
  徳島県徳島市あわぎんホール
- Year and Date
  2015-06-24
- Data Source
  KAKENHI-PROJECT-24687015
[Presentation] ヒト由来鉄還元酵素Dcytbの反応速度論解析2015
- Author(s)
  武田英恵、冨樫ひろ美、木村哲就、Grant Mauk、杉本宏、城宜嗣
- Organizer
  第9回バイオ関連科学シンポジウム
- Place of Presentation
  熊本県熊本市熊本大学
- Year and Date
  2015-09-10
- Data Source
  KAKENHI-PROJECT-24687015
[Presentation] Stopped-flow kinetic analysis of human duodenal cytochrome b5612015
- Author(s)
  Hanae Takeda, Hiromi Togashi, Tetsunari Kimura, Grant Mauk, Hiroshi Sugimoto, Yoshitsugu Shiro
- Organizer
  International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015)
- Place of Presentation
  アメリカ, ホノルル, Hawaii Convention Center
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24687015
[Presentation] 病原菌由来ヘムトランスポーターの結晶構造に基づく基質輸送機構2015
- Author(s)
  中村希、直江洋一、土井章弘、中村寛夫、杉本宏、城宜嗣
- Organizer
  第15回日本蛋白質科学会年会
- Place of Presentation
  徳島県徳島市あわぎんホール
- Year and Date
  2015-06-25
- Data Source
  KAKENHI-PUBLICLY-15H01655
[Presentation] Stopped-flow Analysis on the Reaction of Ascorbate with Duodenal Cytochrome b5612015
- Author(s)
  Hanae Takeda, Hiromi Togashi, Tetsunari Kimura, Grant A. Mauk, Hiroshi Sugimoto, Yoshitsugu Shiro
- Organizer
  Metals in Biology in Wako
- Place of Presentation
  埼玉県和光市理化学研究所
- Year and Date
  2015-06-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24687015
[Presentation] Structural analysis of a periplasmic heme-binding protein in bacterial heme importer system2015
- Author(s)
  Md. Mahfuzur Rahman, Nozomi Nakamura, Hiroshi Sugimoto, Yoshitsugu Shiro
- Organizer
  13th Asian Crystallographic Association Meeting (AsCA 2015)
- Place of Presentation
  India, Kolkata, Science City
- Year and Date
  2015-12-05
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01655
[Presentation] ヒト由来鉄還元酵素DcytbのStopped-Flow法による機能解析2015
- Author(s)
  武田英恵、冨樫ひろ美、木村哲就、Grant Mauk、杉本宏、城宜嗣
- Organizer
  第15回日本蛋白質科学会年会
- Place of Presentation
  徳島県徳島市あわぎんホール
- Year and Date
  2015-06-24
- Data Source
  KAKENHI-PROJECT-24687015
[Presentation] ヒト由来鉄還元酵素Dcytbの機能解析と結晶化2015
- Author(s)
  冨樫ひろ美、武田英恵、木村哲就、Grant A. Mauk、杉本宏、城宜嗣
- Organizer
  平成27年度日本結晶学会年会
- Place of Presentation
  大阪府堺市大阪府立大学
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-24687015
[Presentation] ヒト由来Dcytbによる非ヘム鉄還元反応の速度論解析2015
- Author(s)
  冨樫ひろ美、武田英恵、木村哲就、Grant A. Mauk、杉本宏、城宜嗣
- Organizer
  第38回日本分子生物学会年会、第88回日本生化学会大会合同年会
- Place of Presentation
  兵庫県神戸市神戸国際会議場
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-24687015
[Presentation] Structure and mechanism of bacterial heme transporter2015
- Author(s)
  Hiroshi Sugimoto, Youichi Naoe, Nozomi Nakamura, Akihiro Doi, Hiro Nakamura, Yoshitsugu Shiro
- Organizer
  Metals in Biology in Wako
- Place of Presentation
  埼玉県和光市理化学研究所
- Year and Date
  2015-06-16
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01655
[Presentation] Structural basis of the bacterial heme transporter2015
- Author(s)
  Hiroshi Sugimoto
- Organizer
  International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015)
- Place of Presentation
  アメリカ, ホノルル, Hawaii Convention Center
- Year and Date
  2015-12-15
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01655
[Presentation] Inward-facing conformation of the bacterial heme transporter.2014
- Author(s)
  Hiroshi Sugimoto, Youichi Naoe, Nozomi Nakamura, Akihiro Doi, Yoshitsugu Shiro
- Organizer
  IUCr 2014 -23rd Congress
- Place of Presentation
  Canada, Montreal
- Year and Date
  2014-08-11
- Data Source
  KAKENHI-PUBLICLY-25121739
[Presentation] バクテリアのヘム輸送ABCトランスポーターの立体構造と分子機構2014
- Author(s)
  杉本宏
- Organizer
  第87回日本生化学会年会
- Place of Presentation
  京都府京都市国立京都国際会館
- Year and Date
  2014-10-17
- Invited
- Data Source
  KAKENHI-PUBLICLY-25121739
[Presentation] 病原菌ヘムトランスポーターのX線結晶構造解析2014
- Author(s)
  杉本宏、直江洋一、中村希、土井章弘、城宜嗣
- Organizer
  第41回生体分子科学討論会
- Place of Presentation
  福岡県福岡市九州大学西新プラザ
- Year and Date
  2014-06-06
- Data Source
  KAKENHI-PUBLICLY-25121739
[Presentation] Conformational change of Periplasmic Heme-Binding Protein in ABC transporter2014
- Author(s)
  Nozomi Nakamura, Youichi Naoe, Akihiro Doi, Hiroshi Sugimoto, Yoshitsugu Shiro
- Organizer
  第2回ピコバイオロジー研究所国際シンポジウム
- Place of Presentation
  兵庫県赤穂郡兵庫県立先端科学技術支援センター
- Year and Date
  2014-09-10
- Data Source
  KAKENHI-PUBLICLY-25121739
[Presentation] Conformational change of periplasmic heme-binding protein in ABC transporter.2014
- Author(s)
  Nozomi Nakamura, Youichi Naoe, Akihiro Doi, Yoshitsugu Shiro, Hiroshi Sugimoto
- Organizer
  IUCr 2014 -23rd Congress
- Place of Presentation
  Canada, Montreal
- Year and Date
  2014-08-11
- Data Source
  KAKENHI-PUBLICLY-25121739
[Presentation] 病原菌由来ヘムトランスポーターのX線結晶構造解析2014
- Author(s)
  中村希、直江洋一、土井章弘、杉本宏、城宜嗣
- Organizer
  平成26年度日本結晶学会年会
- Place of Presentation
  東京都文京区東京大学弥生講堂
- Year and Date
  2014-11-01
- Data Source
  KAKENHI-PUBLICLY-25121739
[Presentation] Transmembrane Electron Transfere by Human Duodenal cytochrome b2013
- Author(s)
  冨樫ひろ美, 杉本宏, Grant Mauk, 城宜嗣
- Organizer
  第86回生化学大会
- Place of Presentation
  横浜、パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24687015
[Presentation] 病原菌由来へムトランスポーターの機能・構造解析2013
- Author(s)
  杉本宏, 直江洋一, 沢辺美亜, 城宜嗣
- Organizer
  蛋白質科学会
- Place of Presentation
  鳥取市
- Data Source
  KAKENHI-PUBLICLY-25121739
[Presentation] 病原菌由来ヘム輸送タンパク質の結晶構造2013
- Author(s)
  中村希・直江洋一・杉本宏・城宜嗣
- Organizer
  日本結晶学会年会
- Place of Presentation
  熊本市
- Data Source
  KAKENHI-PUBLICLY-25121739
[Presentation] Structure and reaction mechanism of metalloproteins2012
- Author(s)
  Hiroshi Sugimoto
- Organizer
  Advances in Protein Crystallography
- Place of Presentation
  北海道大学(札幌)(招待講演)
- Year and Date
  2012-03-17
- Data Source
  KAKENHI-PUBLICLY-23121531
[Presentation] Reaction mechanism of indoleamine 2,3-dioxygenase revealed by crystallo graphic and spectroscopic analysis2012
- Author(s)
  Hiroshi Sugimoto
- Organizer
  13th Symposium of the International Study Group of Tryptophan Research
- Place of Presentation
  Masonic Centre (Sydney, Australia)(招待講演)
- Year and Date
  2012-11-08
- Data Source
  KAKENHI-PROJECT-24687015
[Presentation] Molecular Structures and Mechanism of Bacterial Nitric Oxide Reductase2011
- Author(s)
  Hino, T., Matsumoto, Y., Pisliakov, A., Nagano, S., Sugimoto, H., Sugita, Y., Shiro, Y
- Organizer
  Third Korea-Japan Seminars on Biomolecular Sciences - Experiments and Simulations
- Place of Presentation
  Jeju, Korea
- Year and Date
  2011-02-28
- Data Source
  KAKENHI-PROJECT-21245041
[Presentation] Structure and catalytic mechanism of iron-dependent enzymes2011
- Author(s)
  Hiroshi Sugimoto
- Organizer
  PDB40 : A Special Symposium Celebrating the 40th Anniversary of the PDB
- Place of Presentation
  コールドスプリングハーバー研究所(コールドスプリングハーバー、USA)
- Year and Date
  2011-11-28
- Data Source
  KAKENHI-PUBLICLY-23121531
[Presentation] Molecular Structures and Mechanism of Bacterial Nitric Oxide Reductase2011
- Author(s)
  T.Hino, Y.Matsumoto, Andrei Pisliakov, S.Nagano, H.Sugimoto, Yuji Sugita, Y.Shiro
- Organizer
  Third Korea-Japan Seminars on Biomolecular Sciences : -Exneriments and Simulations
- Place of Presentation
  Jeju, Korea
- Year and Date
  2011-02-28
- Data Source
  KAKENHI-PROJECT-21245041
[Presentation] 嫌気呼吸系の一酸化窒素還元酵素の構造と分子進化2010
- Author(s)
  永野真吾、松本悠史、當舎武彦、日野智也、杉本宏、城宜嗣
- Organizer
  第10回日本蛋白質化学会
- Place of Presentation
  札幌
- Year and Date
  2010-06-17
- Data Source
  KAKENHI-PROJECT-21245041
[Presentation] シトクロムP450(CYP105A1)の立体構造に基づくビタミンD水酸化反応のデザインと応用2010
- Author(s)
  杉本宏、林恵子、安田佳織、池田進之介、新京楽、鎌倉昌樹、生城真一、城宜嗣、榊利之
- Organizer
  第10回日本蛋白質化学会
- Place of Presentation
  札幌
- Year and Date
  2010-06-17
- Data Source
  KAKENHI-PROJECT-21245041
[Presentation] 二成分情報伝達系複合体構造からわかる環境変化感知からリン酸化への生体シグナル変換機構2010
- Author(s)
  杉本宏、山田斉爾、中村寛夫、城宜嗣
- Organizer
  日本結晶学会2010年度年会
- Place of Presentation
  吹田
- Year and Date
  2010-12-05
- Data Source
  KAKENHI-PROJECT-21245041
[Presentation] CYP105A1二重変異体発現放線菌によるビタミンD_3の代謝2010
- Author(s)
  安田佳織, 杉本宏, 橘高敦史, 榊利之, 他5名
- Organizer
  日本ビタミン学会第62回大会
- Place of Presentation
  盛岡
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] CYP105A1二重変異体によるビタミンD_3の代謝とその反応機構2010
- Author(s)
  安田佳織、杉本宏、橘高敦史、榊利之, 他5名
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] Cooperative L-Trp binding to human tryptophan 2,3-dioxygenase revealed by resonance Raman spectroscopy2010
- Author(s)
  福村栄維子、杉本宏、三角祐子、小倉尚志、城宜嗣
- Organizer
  第33回日本分子生物学年会・第83回日本生化学会大会合同大会(BMB2020)
- Place of Presentation
  神戸
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-21245041
[Presentation] Two-component regulatory System : Cellular signal transduction systemssensing exogenous stimuli2010
- Author(s)
  Yoshitsugu Shiro, Hiro Nakamura, Yoko Ito, Hiroshi Sugimoto
- Organizer
  Pacifichem 2010
- Place of Presentation
  Waikiki, Hawaii, USA
- Year and Date
  2010-12-16
- Data Source
  KAKENHI-PROJECT-21245041
[Presentation] CYP105A1二重変異体によるビタミンD_3の代謝とその反応機構2010
- Author(s)
  安田佳織、杉本宏、橘高敦史、榊利之(他5名)
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Data Source
  KAKENHI-PROJECT-21380067
[Presentation] ヘム輸送タンパク質の構造解析2010
- Author(s)
  直江洋一、杉本宏、城宜嗣
- Organizer
  第10回日本蛋白質化学会
- Place of Presentation
  札幌
- Year and Date
  2010-06-17
- Data Source
  KAKENHI-PROJECT-21245041
[Presentation] Two-Component Regulatory System: Cellular Signal Transduction Systems Sensing Exogenous Stimuli2010
- Author(s)
  Shiro, Y., Nakamura, H., Ito, Y., Sugimoto, H
- Organizer
  2010 International Chemical Congress of Paci.c Basin Societies
- Place of Presentation
  Honolulu, USA
- Data Source
  KAKENHI-PROJECT-21245041
[Presentation] Nitric Oxide Reductases: Chemistry of N-O bond Cleavage and N-N Bond Formation2010
- Author(s)
  Shiro, Y., Hino, T., Matsumoto, Y., Nagano, S., Sugimoto, H., Tosha, T
- Organizer
  Sixth International Conference on Porphyrins and Phtalocyanines
- Place of Presentation
  New Mexico, USA
- Data Source
  KAKENHI-PROJECT-21245041
[Presentation] Nitric Oxide Reductase ; Chemistry of N-O Bond Cleavage and N-N Bond Formation2010
- Author(s)
  Yoshitsugu Shiro, Tomoya Hino, Yushi Matsumoto, Shingo Nagano, Hiroshi Sugimoto, Takehiko Tosha
- Organizer
  Sixth International Conference on Porphyrins and Phthalocyanines (ICPP-6)
- Place of Presentation
  Albuquerque, Mew Mexico, USA
- Year and Date
  2010-07-06
- Data Source
  KAKENHI-PROJECT-21245041
[Presentation] Role of the Amino Acid Residues in the Active Site of Human Indoleamine 2, 3-Dioxygenase2009
- Author(s)
  M.Horitani, E.Kometani, H.Sugimoto, Y.Shiro
- Organizer
  14th International Conference of Biological Inorganic Chemistry
- Place of Presentation
  Nagoya, Japan
- Data Source
  KAKENHI-PROJECT-20050033
[Presentation] Cooperative L-Trp Binding to Human Tryptophan 2,3-Dioxygenase Revealed by Resonance Raman Spectroscopy2009
- Author(s)
  E.Fukumura, H.Sugimoto, Y.Misumi, T.Ogura, Y.Shiro
- Organizer
  14th International Conference of Biological Inorganic Chemistry
- Place of Presentation
  Nagoya, Japan
- Data Source
  KAKENHI-PROJECT-20050033
[Presentation] 共鳴ラマン分光法によるトリプトファン2,3ジオキシゲナーゼの反応機構解析2009
- Author(s)
  福村栄維子、三角裕子、杉本宏、永野真吾、瀧尾こう二、井柳尭、小倉尚志、城宜嗣
- Organizer
  第46回生物物理学会
- Place of Presentation
  徳島、日本
- Year and Date
  2009-12-03
- Data Source
  KAKENHI-PROJECT-20050033
[Presentation] Role of the amino acid residues in the active site of human indoleamine 2,3-dioxygenase2009
- Author(s)
  Horitani M., Kometani E., Sugimoto H., Shiro Y.
- Organizer
  14th International Conference on Biological Inorganic Chemistry (ICBIC 14)
- Place of Presentation
  Nagoya, Japan
- Year and Date
  2009-07-26
- Data Source
  KAKENHI-PROJECT-21245041
[Presentation] DFT and ONION Studies on a Missing Piece in Our Understanding of Heme Chemistry : Bacterial Tryptophan 2, 3-Dioxygenase(TDO)2009
- Author(s)
  L.W.Chung, X.Li, H.Sugimoto, Y.Shiro, K.Morokuma
- Organizer
  14th International Conference of Biological Inorganic Chemistry
- Place of Presentation
  Nagoya, Japan
- Data Source
  KAKENHI-PROJECT-20050033
[Presentation] Detection of the Iron-Oxygen Stretching Raman Mode for Human Indoleamine 2, 3 Dioxygenase in the Oxygenated Form2009
- Author(s)
  S.Yanagishita, K.Yotsuya, M.Horitani, H.Sugimoto, Y.Shiro, Y.Hashiwaki, T.Ogura
- Organizer
  14th International Conference of Biological Inorganic Chemistry
- Place of Presentation
  Nagoya, Japan
- Data Source
  KAKENHI-PROJECT-20050033
[Presentation] Cooperative L-Trp binding to human tryptophan 2,3-dioxgenase revealed by Resonance Raman Spectroscopy2009
- Author(s)
  Fukumura E., Sugimoto H., Misumi Y., Ogura T., Shiro Y.
- Organizer
  14th International Conference on Biological Inorganic Chemistry (ICBIC 14)
- Place of Presentation
  Nagoya, Japan
- Year and Date
  2009-07-26
- Data Source
  KAKENHI-PROJECT-21245041
[Presentation] 膜貫通型一酸化窒素還元酵素の結晶構造2009
- Author(s)
  松本悠史、杉本宏、日野智哉、永野真吾、城宜嗣
- Organizer
  第46回生物物理学会
- Place of Presentation
  徳島、日本
- Year and Date
  2009-12-03
- Data Source
  KAKENHI-PROJECT-20050033
[Presentation] Crystal structure of cytochrome P450 105Al in complex with 1α, 2-dihydroxyvitamin D_32008
- Author(s)
  Sugimoto H., Shinkyo R., Hayashi K., Yoneda S., Yamada M., Kamakura M., Ikushiro S., Shiro Y., and Sakaki T.
- Organizer
  21th Congress and General Assembly of the International Union of Crystallography(IUCr2008)
- Place of Presentation
  Osaka, Japan
- Data Source
  KAKENHI-PROJECT-20050033
[Presentation] 膜貫通型一酸化窒素還元酵素の結晶構造2008
- Author(s)
  松本悠史, 杉本宏, 日野智也, 永野真吾, 城宜嗣
- Organizer
  第46回日本生物物理学会年会
- Place of Presentation
  福岡, 日本
- Data Source
  KAKENHI-PROJECT-20050033
[Presentation] Structure of cytochrome P450 105A1 in complex with 1α, 25-dihydroxyvitamin D_32008
- Author(s)
  Sugimoto H., Shinkyo R., Hayashi K., Yoneda S., Yamasa M., Kamakura M., Ikushiro S., Shiro Y., and Sakaki T.
- Organizer
  9th International Symposium on Cytochrome P450 Biodiversity and Biotechnology
- Place of Presentation
  Nice France
- Data Source
  KAKENHI-PROJECT-20050033
[Presentation] 共鳴ラマン分光法によるトリプトファン2, 3-ジオキシゲナーゼの反応機構解析2008
- Author(s)
  福村栄維子, 三角裕子, 杉本宏, 永野真吾, 瀧尾擴士, 井柳堯, 小倉尚志, 城宜嗣,
- Organizer
  第46回日本生物物理学会年会
- Place of Presentation
  福岡, 日本
- Data Source
  KAKENHI-PROJECT-20050033
[Presentation] シトクロムP450 105A1 の結晶構造とビタミンD_3活性化反応の分子メカニズム2008
- Author(s)
  杉本宏, 新京楽, 林恵子, 米田幸世, 山田雅人, 鎌倉昌樹, 生城真一, 城宜嗣, 榊利之,
- Organizer
  第58回錯体化学討論会
- Place of Presentation
  金沢, 日本
- Data Source
  KAKENHI-PROJECT-20050033
[Presentation] 共鳴ラマン分光法によるトリプトファン2,3-ジオキシゲナーゼの反応機構解析2008
- Author(s)
  福村栄維子、三角裕子、杉本宏、永野真吾、瀧尾擴士、井柳〓、小倉尚志、城宜嗣
- Organizer
  日本生物物理学会
- Place of Presentation
  福岡
- Year and Date
  2008-12-03
- Data Source
  KAKENHI-PROJECT-19770094
[Presentation] 共鳴ラマン分光法によるインドールアミン2,3ジオキシゲナーゼの解析2007
- Author(s)
  四ッ谷景子、杉本宏、大槻崇史、佐藤秀明、吉田匡、小倉尚志、城宜嗣
- Organizer
  日本生物物理学会年会
- Place of Presentation
  横浜
- Year and Date
  2007-12-21
- Data Source
  KAKENHI-PROJECT-19770094
[Presentation] Cytochrome P450SU-1 (CYP105A1)の結晶構造と活性型ビタミンD生成反応のメカニズム2007
- Author(s)
  杉本宏
- Organizer
  日本生物物理学会年会
- Place of Presentation
  横浜
- Year and Date
  2007-12-23
- Data Source
  KAKENHI-PROJECT-19770094
[Presentation] ヒト由来Tryptophan 2,3-dioxygenaseの分光学的解析2007
- Author(s)
  福村栄維子、杉本宏、永野真吾、瀧尾擴士、井柳尭、小倉尚志、城宜嗣
- Organizer
  日本生物物理学会年会
- Place of Presentation
  横浜
- Year and Date
  2007-12-21
- Data Source
  KAKENHI-PROJECT-19770094
[Presentation] Cytochrome P450SU-1(CYP105A1)の結晶構造と活性型ビタミンD生成反応のメカニズム2007
- Author(s)
  杉本宏, 他9名
- Organizer
  日本生物物理学会第45回年会
- Place of Presentation
  横浜,日本
- Year and Date
  2007-12-23
- Data Source
  KAKENHI-PROJECT-16074217
[Presentation] ヒト由来Indoleamine 2,3-dioxygenaseの構造に基づいた変異体解析2007
- Author(s)
  米谷依梨紗、杉本宏、エドワードヴォッテロ、四ッ谷景子、吉田匡、城宜嗣
- Organizer
  日本生化学会・日本分子生物学会合同年会
- Place of Presentation
  横浜
- Year and Date
  2007-12-21
- Data Source
  KAKENHI-PROJECT-19770094
[Presentation] Reaction Mechanism of Heme-containing Oxygenases Based on Their Molecular Structures2006
- Author(s)
  Shiro Y, Sugimoto H
- Organizer
  20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
- Place of Presentation
  Kyoto
- Year and Date
  2006-06-01
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16074217
[Presentation] Reaction Mechanism oi Heme-containing Oxygenases Based on Their Molecular Structures2006
- Author(s)
  Shiro Y, Sugimoto H
- Organizer
  20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
- Place of Presentation
  Kyoto
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16074217
[Presentation] 病原菌由来ヘム結合タンパク質における柔軟なヘム認識
- Author(s)
  中村希, 直江洋一, 杉本宏, 城宜嗣
- Organizer
  第6回日本生物物理学会中国四国支部大会
- Place of Presentation
  鳥取県鳥取市とりぎん文化会館
- Year and Date
  2014-05-17 – 2014-05-18
- Data Source
  KAKENHI-PUBLICLY-25121739
[Presentation] Challenges in the structure determination of membrane proteins by X-ray crystallography.
- Author(s)
  Hiroshi Sugimoto
- Organizer
  EMtech Colloquium
- Place of Presentation
  Malaysia, Putrajaya
- Year and Date
  2014-05-26 – 2014-05-27
- Invited
- Data Source
  KAKENHI-PUBLICLY-25121739
[Presentation] ヒトの鉄吸収に関わる膜タンパク質Dcytbの電子伝達機構の解明
- Author(s)
  冨樫ひろ美, 杉本宏, Grant Mauk, 城宜嗣
- Organizer
  分子システム研究第3回春季研究会
- Place of Presentation
  滋賀県彦根市かんぽの宿彦根
- Year and Date
  2014-04-24 – 2014-04-25
- Data Source
  KAKENHI-PROJECT-24687015
[Presentation] ヒト由来鉄還元タンパク質Dcytbの分子内電子移動反応に関する研究
- Author(s)
  冨樫ひろ美, 杉本宏, Grant Mauk, 城宜嗣
- Organizer
  第14回日本蛋白質科学会年会
- Place of Presentation
  神奈川県横浜市ワークピア横浜
- Year and Date
  2014-06-25 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-24687015
[Presentation] ヘムトランスポーターの結晶構造から見えてきた動的構造と曖昧な分子認識
- Author(s)
  杉本宏
- Organizer
  分子システム研究第3回春季研究会
- Place of Presentation
  滋賀県彦根市かんぽの宿彦根
- Year and Date
  2014-04-24 – 2014-04-25
- Data Source
  KAKENHI-PUBLICLY-25121739
[Presentation] 鉄吸収に関与するヒト由来Cytochrome b561の電子伝達機構の解明
- Author(s)
  冨樫ひろ美, 杉本宏, Grant Mauk, 城宜嗣
- Organizer
  第27回生物無機化学夏季セミナー
- Place of Presentation
  兵庫県姫路市円教寺会館
- Year and Date
  2014-08-29 – 2014-08-31
- Data Source
  KAKENHI-PROJECT-24687015

1. SHIRO Yoshitsugu (70183051)

# of Collaborated Projects: 6 results

# of Collaborated Products: 96 results
2. KIMURA TETSUNARI (70506906)

# of Collaborated Projects: 3 results

# of Collaborated Products: 20 results
3. NAGANO Shingo (60286440)

# of Collaborated Projects: 2 results

# of Collaborated Products: 18 results
4. Hanae Takeda

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
5. KIKUCHI Akihiro (90321752)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TOSHA Takehiro (00548993)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
7. SAKAKI Toshiyuki (70293909)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
8. KITTAKA Atsushi (00214833)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
9. IKUSHIRO Shinichi (50244679)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. KIM Misa (40373295)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. TSUBAKI Motonari (00145046)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Kambe Taiho (90303875)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 松永勇 (00254425)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 小倉壽 (10115222)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 山田斉爾 (20360662)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 日野智也 (40373360)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
17. 汲田英之 (70332286)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 澤井仁美 (50584851)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
19. 真栄城正寿 (40744248)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 宗兼将之 (80804806)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 堀谷正樹 (80532134)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
22. 大久保晋 (80283901)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. Hiromi Togashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
24. Takeshi Urano

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
25. Nami Yashima

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. HAYASHI Sae

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
27. ONISHI Kizashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
28. SHIMONAKA Misato

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. FUJII Koichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. Mauk Grant A.

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
31. 渡辺芳人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 忍久保洋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SUGIMOTO Hiroshi 杉本 宏

Research Projects

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新しい動的構造解析法の開発とABCトランスポーターへの応用Principal Investigator

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Structure and mechanism of bacterial heme transporterPrincipal Investigator

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ヘム酵素が生成する酸化活性種の精密構造解析Principal Investigator

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Structure analysis of monooxygenase using XFEL and microfluidic devicePrincipal Investigator

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Strucutral analysis of the membrane proteins involved in metal transportPrincipal Investigator

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Structural analysis of bacterial heme transporterPrincipal Investigator

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ヘムトランスポーターの動的結晶構造解析Principal Investigator

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病原微生物におけるヘム獲得システムの構造基盤Principal Investigator

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Structure and mechanism of the iron transport system in humanPrincipal Investigator

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病原微生物におけるヘムシグナリング複合体の構造学的研究Principal Investigator

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Principal Investigator

SUGIMOTO Hiroshi 杉本宏