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OHNISHI Hiroshi  大西 広志

Researcher Number 90553876
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-7863-4519
Affiliation (Current) 2025: 高知大学, 教育研究部医療学系臨床医学部門, 准教授
Affiliation (based on the past Project Information) *help 2015: 高知大学, 教育研究部医療学系臨床医学部門, 助教
2011 – 2014: 高知大学, 教育研究部医療学系, 助教
2013: 高知大学, 医歯学系, 助教
2011: 高知大学, 教育研究部・医療学系, 助教
2009: 高知大学, 教育研究部・医療学系, 助教
2009: 高知大学, 教育研究部医療学系, 助教
Review Section/Research Field
Principal Investigator
Respiratory organ internal medicine
Except Principal Investigator
Respiratory organ internal medicine
Keywords
Principal Investigator
CD8 / 気道過敏性 / 好酸球性気道炎症 / 肥満 / CD8陽性T細胞 / 喘息
Except Principal Investigator
KL-6 / MUC1 / 肺障害 / バイオマーカー … More / 動物モデル / 間質性肺炎 / TNF / 閉塞性肺疾患 / 全身性炎症 / 内臓脂肪 / 併存症 / COPD / 非閉塞性肺疾患 / 急性肺障害 / 肺線維症 / 急性呼吸促拍症候群 / ムチン / ムチン / 成人呼吸促迫症候群 / 汎発性血管内凝固症候群 / セレクチン / 急性呼吸窮迫症候群 / MUC1ムチン Less
  • Research Projects

    (5 results)
  • Research Products

    (36 results)
  • Co-Researchers

    (15 People)
  •  Analysis of lung injury models by using human MUC1 transgenic mice.

    • Principal Investigator
      KUBOTA TETSUYA
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Kochi University
  •  Mechanisms for systemic inflammation in COPD

    • Principal Investigator
      YOKOYAMA AKIHITO
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Kochi University
  •  Clinical application and expression mechanisms for KL-6/MUC1 having a selectin ligand

    • Principal Investigator
      YOKOYAMA AKIHITO
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Kochi University
  •  The role of visceral adipose tissue CD8+ T cells in obese murine asthma modelPrincipal Investigator

    • Principal Investigator
      OHNISHI Hiroshi
    • Project Period (FY)
      2011 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Kochi University
  •  Clinicopathological role of kl-6/muc1 with selectin ligand

    • Principal Investigator
      YOKOYAMA Akihito
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Kochi University

All 2016 2014 2013 2012 2011 Other

All Journal Article Presentation Book

  • [Book] 一般検査所見の評価. 特発性間質肺炎の治療と管理2013

    • Author(s)
      大西広志, 横山彰仁
    • Publisher
      克誠堂出版
    • Data Source
      KAKENHI-PROJECT-23390222
  • [Book] 特発性間質性肺炎の治療と管理2013

    • Author(s)
      大西広志、横山彰仁
    • Total Pages
      6
    • Publisher
      克誠堂
    • Data Source
      KAKENHI-PROJECT-23390222
  • [Book] 一般検査所見の評価.特発性間質肺炎の治療と管理2013

    • Author(s)
      大西広志、横山彰仁
    • Publisher
      克誠堂出版
    • Data Source
      KAKENHI-PROJECT-24659405
  • [Journal Article] Carboplatin plus Weekly Paclitaxel with Bevacizumab for First-line Treatment of Non-Small Cell Lung Cancer.2016

    • Author(s)
      Tetsuya Kubota, Yoshio Okano, Mizu Sakai, Masato Takaoka, Tsukie Tsukuda, Kazuki Anabuki, Shigeo Kawase, Shintaro Miyamoto, Hiroshi Ohnishi, Nobuo Hatakeyama, Hisanori Machida, Tomoyuki Urata, Akira Yamamoto, Fumitaka Ogushi, Akihito Yokoyama
    • Journal Title

      Anticancer Research

      Volume: 36 Pages: 307-312

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25461191
  • [Journal Article] Analysis of lung injury models by using human MUC1 transgenic mice2016

    • Author(s)
      Tetsuya Kubota, Mizu Sakai, Shin Akita, Shigeo Kawase, Hiroshi Ohnishi, Akihito Yokoyama
    • Journal Title

      Am J Respir Crit Care Med

      Volume: 193

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25461191
  • [Journal Article] GLCCI1 variant accelerates pulmonary function decline in patients with asthma receiving inhaled corticosteroids.2014

    • Author(s)
      Izuhara Y, Matsumoto H, Kanemitsu Y, Izuhara K, Tohda Y, Horiguchi T, Kita H, Kuwabara K, Tomii K, Otsuka K, Fujimura M, Ohkura N, Tomita K, Yokoyama A, Ohnishi H, Nakano Y, Oguma T, Hozawa S, Nagasaki T, Ito I, Oguma T, Inoue H, Tajiri T, Iwata T, Ono J, Ohta S, Tamari M, Hirota T, Yokoyama T, Niimi A, Mishima M.
    • Journal Title

      Allergy

      Volume: 69 Issue: 5 Pages: 668-73

    • DOI

      10.1111/all.12400

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23591117, KAKENHI-PROJECT-23591120, KAKENHI-PROJECT-23591142, KAKENHI-PROJECT-24591466, KAKENHI-PROJECT-25293224
  • [Journal Article] Seasonal variation of serum KL-6 concentrations is greater in patients with hypersensitivity pneumonitis.2014

    • Author(s)
      Ohnishi H, Miyamoto S, Kawase S, Kubota T, Yokoyama A.
    • Journal Title

      BMC Pulm Med

      Volume: 14 Issue: 1 Pages: 129-129

    • DOI

      10.1186/1471-2466-14-129

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23591120, KAKENHI-PROJECT-25461191
  • [Journal Article] Integrating longitudinal information on pulmonary function and inflammation using asthma phenotypes.2014

    • Author(s)
      Nagasaki T, Matsumoto H, Kanemitsu Y, Izuhara K, Tohda Y, Kita H, Horiguchi T, Kuwabara K, Tomii K, Otsuka K, Fujimura M, Ohkura N, Tomita K, Yokoyama A, Ohnishi H, Nakano Y, Oguma T, Hozawa S, Ito I, Oguma T, Inoue H, Tajiri T, Iwata T, Izuhara Y, Ono J, Ohta S, Yokoyama T, Niimi A, Mishima M
    • Journal Title

      J Allergy Clin Immunol

      Volume: 133 Issue: 5 Pages: 1474-1477

    • DOI

      10.1016/j.jaci.2013.12.1084

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22249031, KAKENHI-PROJECT-23591117, KAKENHI-PROJECT-23591120, KAKENHI-PROJECT-23591142, KAKENHI-PROJECT-23591146, KAKENHI-PROJECT-24591466
  • [Journal Article] Leukotriene B4 receptor 1 is differentially expressed on peripheral T cells of steroid-sensitive and -resistant asthmatics.2014

    • Author(s)
      Chung EH, Jia Y, Ohnishi H, 他6名
    • Journal Title

      Ann Allergy Asthma Immunol.

      Volume: 112 Issue: 3 Pages: 211-216.e1

    • DOI

      10.1016/j.anai.2013.12.006

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591120
  • [Journal Article] Increased periostin associates with greater airflow limitation in patients receiving inhaled corticosteroids2013

    • Author(s)
      Kanemitsu Y, Mishima M,et al.
    • Journal Title

      J Allergy Clin Immunol

      Volume: 132 Issue: 2 Pages: 305-312

    • DOI

      10.1016/j.jaci.2013.04.050

    • NAID

      120005342661

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249031, KAKENHI-PROJECT-23591117, KAKENHI-PROJECT-23591120, KAKENHI-PROJECT-23591142, KAKENHI-PROJECT-24591466, KAKENHI-PROJECT-24659405, KAKENHI-PROJECT-25293224
  • [Journal Article] A novel lung injury animal model using KL-6-measurable human MUC1- expressing mice2013

    • Author(s)
      Sakai M, Kubota T, Ohnishi H, Yokoya ma A
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 432 Issue: 3 Pages: 460-5

    • DOI

      10.1016/j.bbrc.2013.01.123

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390222, KAKENHI-PROJECT-23591120, KAKENHI-PROJECT-24659405
  • [Journal Article] IL-13-producing BLT1-positive CD8 cells are increased in asthma and are associated with airway obstruction.2013

    • Author(s)
      Dakhama A, Collins ML, Ohnishi H, 他6名
    • Journal Title

      Allergy

      Volume: 68 Issue: 5 Pages: 666-73

    • DOI

      10.1111/all.12135

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591120
  • [Journal Article] A novel lung injury animal model using KL-6-measurable human MUC1-expressing mice2013

    • Author(s)
      Mizu Sakai, Tetsuya Kubota, Hiroshi Ohnishi, Akihito Yokoyama
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 432 Pages: 460-465

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25461191
  • [Journal Article] Loss of T regulatory cell suppression following signaling through glucocorticoid-induced tumor necrosis receptor (GITR) is dependent on c-Jun N-terminal kinase activation.2012

    • Author(s)
      Joetham A, Ohnishi H, 他6名
    • Journal Title

      J Biol Chem

      Volume: 287 Issue: 21 Pages: 17100-8

    • DOI

      10.1074/jbc.m111.316943

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591120
  • [Journal Article] Targeting CXCR3 reduces ligand-induced T-cell activation but not development of lung allergic responses.2011

    • Author(s)
      Shin YS, Takeda K, Ohnishi H, 他9名
    • Journal Title

      Ann Allergy Asthma Immunol.

      Volume: 107 Issue: 2 Pages: 145-53

    • DOI

      10.1016/j.anai.2011.04.013

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591120
  • [Journal Article] CD8 regulates T regulatory cell production of IL-6 and maintains their suppressive phenotype in allergic lung disease.2011

    • Author(s)
      Joetham A, Okamoto M, Takeda K, Schedel M, Ohnishi H, 他2名
    • Journal Title

      J Immunol.

      Volume: 186 Issue: 1 Pages: 113-20

    • DOI

      10.4049/jimmunol.1001663

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591120
  • [Journal Article] Chronic Hepatitis C Virus Infection is Associated with More Severe Asthma2011

    • Author(s)
      Nakashima T, Yokoyama A, Ohnishi H, 他7名
    • Journal Title

      Allergol. Int.

      Volume: 60 Issue: 3 Pages: 299-304

    • DOI

      10.2332/allergolint.10-OA-0240

    • NAID

      130004723041

    • ISSN
      1323-8930, 1440-1592
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591120, KAKENHI-PROJECT-24659405
  • [Presentation] Analysis of lung injury models by using human MUC1 transgenic mice.2016

    • Author(s)
      Tetsuya Kubota, Mizu Sakai, Shin Akita, Shigeo Kawase, Hiroshi Ohnishi, Akihito Yokoyama
    • Organizer
      American Thoracic Society International Conference 2016
    • Place of Presentation
      San Francisco(アメリカ合衆国)
    • Year and Date
      2016-05-13
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25461191
  • [Presentation] ヒトMUC1トランスジェニックマウスを用いた肺障害モデルの検討2016

    • Author(s)
      酒井 瑞、窪田哲也、秋田 慎、河瀬成穂、大西広志、横山彰仁
    • Organizer
      第56回日本呼吸器学会学術講演会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2016-04-08
    • Data Source
      KAKENHI-PROJECT-25461191
  • [Presentation] Low Lung Volume Is Ass ociated With Visceral Adipose Tissue Inflammation2013

    • Author(s)
      Shigeo Kawase, Shintaro Miyamoto, Hi roshi Ohnishi, Tetsuya Kubota, Tsuto mu Namikawa, Kazuhiro Hanazaki, Akih ito Yokoyama.
    • Organizer
      18^<th> Congress of th e Asian Pacific Society of Respirolo gy
    • Place of Presentation
      パシフィコ横浜,横浜
    • Data Source
      KAKENHI-PROJECT-24659405
  • [Presentation] Preoperative Pulmonary Dysfunction And Comorbidities In Patients Undergoing Surgery2013

    • Author(s)
      Shigeo Kawase, Masato Takaoka, Mizu Sakai, Shintaro Miyamoto, Hiroshi Ohnishi,
    • Organizer
      18th Congress of the Asian Pacific Society of Respirology
    • Place of Presentation
      Yokohama
    • Data Source
      KAKENHI-PROJECT-24659405
  • [Presentation] Low Lung Volume Is Associated With Adipose Tissue Inflammation2013

    • Author(s)
      Kawase S,Miyamoto S,Ohnishi H,Kubota T,Namikawa T,Hanazaki K,Yokoyama A
    • Organizer
      2013 American Thoracic Society International Conference
    • Place of Presentation
      Philadelphia
    • Data Source
      KAKENHI-PROJECT-24659405
  • [Presentation] Low lung volume is associated with visceral adipose tissue inflammation2013

    • Author(s)
      S Kawase , M Takaoka, S Miyamoto ,H Ohnishi , T Kubota,T Namikawa*,K Hanazaki *,
    • Organizer
      European Respiratory Society Annual Congress
    • Place of Presentation
      BARCELONA
    • Data Source
      KAKENHI-PROJECT-24659405
  • [Presentation] Low Lung Volume Is Associated W ith Adipose Tissue Inflammation2013

    • Author(s)
      Kawase S, Miyamoto S, Ohnishi H, Kub ota T, Namikawa T, Hanazaki, Yokoyam a A.
    • Organizer
      2013 American Thoracic Society Internati onal Conference
    • Place of Presentation
      Phi ladelphia convention center,Philadel phia,USA
    • Data Source
      KAKENHI-PROJECT-24659405
  • [Presentation] Low lung volume i s associated with visceral adipose t issue inflammation2013

    • Author(s)
      S Kawase , M Takaoka, S Miyamoto ,H Ohnishi , T Kubota,T Namikawa,K Hana zaki , A Yokoyama.
    • Organizer
      European Respira tory Society Annual Congress
    • Place of Presentation
      Barcelona convention c enter, BARCELONA Spain
    • Data Source
      KAKENHI-PROJECT-24659405
  • [Presentation] Analysis of Lung Injury Models by Using Human MUC1 Transgenic Mice2012

    • Author(s)
      Mizu Sakai, Tetsuya Kubota, Takashi Yamane, Naoki Shiota, Hiroshi Ohnishi, Akihito Yokoyama
    • Organizer
      American Thora cic Society International Conference
    • Place of Presentation
      San Francisco convention center, USA
    • Data Source
      KAKENHI-PROJECT-23390222
  • [Presentation] Activation of Extracellular Signal-Regulated Kinases 1/2 is Essential for the Development of CD8+ T cell-Mediated Allergic Airway Inflammation.2012

    • Author(s)
      Hiroshi Ohnishi
    • Organizer
      East Asia Allergy Symposium
    • Place of Presentation
      Grand Hilton Seoul (Seoul, Korea)
    • Invited
    • Data Source
      KAKENHI-PROJECT-23591120
  • [Presentation] ヒトMUC1トランスジェニックマウスを用いた肺障害モデルの解析2012

    • Author(s)
      酒井瑞, 窪田哲也, 大西広志, 横山彰仁
    • Organizer
      第52回日本呼吸器学会学術講演会
    • Place of Presentation
      神戸コンベンションセンター, 神戸
    • Data Source
      KAKENHI-PROJECT-23390222
  • [Presentation] Pulmonary complications in patients with hematologic diseases2012

    • Author(s)
      Hiroshi Ohnishi, Kazuto Togitani, Mizu Sakai, Ayuko Taniguchi, Takayuki Ikezoe, Tetsuya Kubota, Akihito Yokoyama
    • Place of Presentation
      Vienna convention center, Austria
    • Data Source
      KAKENHI-PROJECT-23390222
  • [Presentation] COPDにおける肺胞上皮マーカーの検討2012

    • Author(s)
      大西広志, 山根高, 濱田典彦, 金月恵, 穴吹和貴, 荒川悠, 酒井瑞, 塩田直樹, 窪田哲也, 横山彰仁
    • Organizer
      第52回日本呼吸器学会学術講演会
    • Place of Presentation
      神戸コンベンションセンター, 神戸
    • Data Source
      KAKENHI-PROJECT-23390222
  • [Presentation] Full Development of Allergen-Induced Airway Hyperresponsiveness Requires Leukotriene B4 Receptor-1 Expression on Both CD4+ and CD8+ T Cells.2011

    • Author(s)
      Ohnishi H, 他4名
    • Organizer
      第51回日本呼吸器学会学術講演会
    • Place of Presentation
      東京(東京国際フォーラム)
    • Data Source
      KAKENHI-PROJECT-23591120
  • [Presentation] ヒトMUC1トランスジェニックマウスを用いた肺線維症モデルの解析2011

    • Author(s)
      酒井瑞, 窪田哲也, 井坂真由香, 山根高, 塩田直樹, 大西広志, 岩本博, 河野修興, 横山彰仁
    • Organizer
      第51回日本呼吸器学会学術講演会
    • Place of Presentation
      東京国際フォーラム, 東京
    • Data Source
      KAKENHI-PROJECT-23390222
  • [Presentation] Synergistic Effects of CD4+ and CD8+ T Cells for the Full Development of Allergen-Induced Airway Hyperresponsiveness Requires Leukotriene B4 Receptor-1 Expression.2011

    • Author(s)
      Ohnishi H, 他5名
    • Organizer
      2011 American Thoracic Society International conference
    • Place of Presentation
      Denver, CO, USA(Colorado Convention Center)
    • Data Source
      KAKENHI-PROJECT-23591120
  • [Presentation] The role of leukotriene B4-dependent migration of T cells in allergic airway inflammation and airway hyperresponsiveness.2011

    • Author(s)
      Ohnishi H.
    • Organizer
      第61回日本アレルギー学会秋期学術大会 日韓中合同シンポジウム
    • Place of Presentation
      東京(グランドプリンスホテル新高輪)
    • Data Source
      KAKENHI-PROJECT-23591120
  • [Presentation] Seasonal variation of serum KL-6 levels in patients with interstitial lung diseases.

    • Author(s)
      Hiroshi Ohnishi, Shintaro Miyamoto, Shigeo Kawase, Tetsuya Kubota, Akihito Yokoyama
    • Organizer
      European Respiratory Society (ERS) 2014
    • Place of Presentation
      Munich, Germany
    • Year and Date
      2014-09-06 – 2014-09-10
    • Data Source
      KAKENHI-PROJECT-25461191
  • [Presentation] 間質性肺炎における血清KL-6の季節変動

    • Author(s)
      大西広志、宮本真太郎、河瀬成穂、窪田哲也、横山彰仁
    • Organizer
      第26回日本アレルギー学会春季臨床大会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2014-05-09 – 2014-05-11
    • Data Source
      KAKENHI-PROJECT-25461191
  • 1.  YOKOYAMA Akihito (30191513)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 18 results
  • 2.  KUBOTA Tetsuya (30274377)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 17 results
  • 3.  SAKAI Mizu (40403886)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 5 results
  • 4.  IKEZOE Takayuki (80294833)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 5.  KOHNO Nobuoki (80215194)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  HATTORI Noboru (00283169)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  ISHIKAWA Nobuhisa (90423368)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  IWAMOTO Hiroshi (60457398)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  KAWASE Shigeo (80642058)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 10.  MIYAMOTO Shintaro (30633995)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 11.  KOMIYAMA Shuzo
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  ITO Isao
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 13.  MISHIMA Michiaki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 14.  松本 久子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 15.  新實 彰男
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results

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