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YOSHIHARA Shinichi
吉原 新一
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Alternative Names
YOSHIHARA/SHIN'ICHI 吉原 新一
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Researcher Number
00037607
Other IDs
Affiliation (based on the past Project Information)
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2004: 広島国際大学, 薬学部, 教授
2002 – 2003: 広島大学, 大学院・医歯薬学総合研究科, 助教授
1998 – 2001: 広島大学, 医学部, 助教授
1986 – 1987: 広島大学, 医学部, 助教授
Review Section/Research Field
Principal Investigator
Environmental pharmacy
/
Science and Engineering
Except Principal Investigator
Neurochemistry/Neuropharmacology
/
医薬分子機能学
/
Environmental pharmacy
/
Biological pharmacy
/
Science and Engineering
Keywords
Principal Investigator
異物代謝酵素 / エストロゲン活性 / アルキルフェノール / 代謝的活性化 / 異物(薬物)代謝酵素 / ビスフェノールA / 異物代謝 / Bisphenol A / Genistein / プロエストロゲン
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/ 内分泌撹乱物質 / アルキルフェノール類 / フェンチオン / 2-ニトロフルオレン / オクチルフェノール / ベンゾフェノン類 / 大豆イソフラボン / Xenobiotic metabolizing enzymes / ラット肝S9 / 内分泌攪乱化学物質 / Biochanin A / Alkylphenols / Metabolic activation / 抗アンドロゲン活性 / 内分泌撹乱化学物質 / Endocrine disrupting chemicals / バイオカニンA / Estrogenicity / ゲニステイン / ヒトP450 / 内分泌攪乱物質
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Except Principal Investigator
パーキンソン病 / Parkinson's disease / テトラヒドロイソキノリン / ドーパミン神経 / パーキンソン病発症物質 / パーキンソン病防御物質 / 1MeTIQ / 内分泌撹乱物質 / Parkinson's disease causing substance / tetrahydroisoquinoline / 細胞培養 / NMDAレセプター / drug-reducing activity / early marker / tetrahydroisogunoline / vitellogenin / neurotoxin / xanthine oxidase / drug metabolism / N-アリル脂肪族ヒドロキサム酸 / menadione / apoptosis / 薬物代謝酵素 / トランスースチルベン / 国際シンポジウム / 内分泌撹乱前駆物質 / 代謝変換 / anti-parkinsonian drug / フラビン酵素 / パーキンソニズム / 代謝機構 / DNAマイクロアレイ / differential display / cDNAマイクロアレイ / ビフェニール / アルデヒドオキシダーゼ / 人体影響 / aldehydeoxidase / ミトコンドリア呼吸鎖阻害 / 1ベンジルTIQ / trans-stilbene / aldehyde oxidase / アルデヒドオキシターゼ / トランス-スチルベン / 神経毒 / 酵素阻害 / 環境リスク / cell culture / エストロゲン / NADPH-cytochrome c reductase / lipoamide clehydrogenase / アポトーシス関連遺伝子 / xanthine cehydrogenace / biphenyl / metabolic activation / proestrogen / アポトーシス / サルゾリノール / flavin enzyme / endocrine disruptor / 薬物代謝 / drug metabolizing enzyme / lipoamide dehydrogenase / 人体汚染 / トランスースチルベンオキシド / rabbit / Parkinson's disease cpreventing substance / structure-activity relationship / 新電子伝達系 / アルデヒド酸化酵素 / 野生生物汚染 / ディファレンシャルディスプレイ / estrogen / guinea pig / ビテロゲニン / バイオアッセイ / 毒性メカニズム / 早期診断技術 / cDNA microaray / new electron transfer system / バイオアッセイ・バイオマーカー / ヒドロキサム酸還元 / 細胞培養系 / 代謝的活性化 / dopaminergic neuron / テトラハイドロイソキノリン
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Research Projects
(
9
results)
Research Products
(
1
results)
Co-Researchers
(
14
People)
Project Start Year (Newest)
Project Start Year (Oldest)
Development of anti-parkinsonian drug using structure-activity relationship
Principal Investigator
OHTA Shigeru
Project Period (FY)
2002 – 2003
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
医薬分子機能学
Research Institution
HIROSHIMA UNIVERSITY
内分泌攪乱物質並びにその前駆物質の代謝変換とホルモン作用の修飾
Principal Investigator
Principal Investigator
吉原 新一
Project Period (FY)
2001 – 2003
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Review Section
Science and Engineering
Research Institution
Hiroshima University
内分泌攪乱物質の環境リスク
Principal Investigator
松井 三郎
Project Period (FY)
2000 – 2004
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Review Section
Science and Engineering
Research Institution
Kyoto University
Research for the Parkinson's disease related proteins using endogenous neurotoxins
Principal Investigator
OHTA Shigeru
Project Period (FY)
2000 – 2001
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Neurochemistry/Neuropharmacology
Research Institution
HIROSHIMA UNIVERSITY
Metabolic Modulation of Estrogenicity of Endocrine Disrupting Chemicals by Cytochrome P450 in Human and Rat Livers
Principal Investigator
Principal Investigator
YOSHIHARA Shin'ichi
Project Period (FY)
2000 – 2001
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Environmental pharmacy
Research Institution
HIROSHIMA UNIVERSITY
Metabolism and endocrine disrupting action of environmental pollutants
Principal Investigator
KITAMURA Shigeyuki
Project Period (FY)
1999 – 2000
Research Category
Grant-in-Aid for Scientific Research (B).
Research Field
Environmental pharmacy
Research Institution
Hiroshima University School of Medicine
Investigation of Parkinson's disease causing substances
Principal Investigator
OHTA Shigeru
Project Period (FY)
1998 – 1999
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
医薬分子機能学
Research Institution
Hiroshima University
Early markers of Parkinson's disease
Principal Investigator
OHTA Shigeru
Project Period (FY)
1998 – 1999
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Neurochemistry/Neuropharmacology
Research Institution
Hiroshima University
Studies on Intra-cellular New Electron Transfer Systems Containing Aldehyde Oxidase as a Component.
Principal Investigator
TATSUMI Kiyoshi
Project Period (FY)
1985 – 1987
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
Biological pharmacy
Research Institution
HIROSHIMA UNIVERSITY
All
2005
All
Journal Article
[Journal Article] Comparative Study of the Endocrine-disrupting Activity of Bisphenol A and 19 Related Compounds.
2005
Author(s)
S.Kitamura, S.Yoshihara, et al.
Journal Title
Toxicological Sciences (In press)
Data Source
KAKENHI-PROJECT-12055101
# of Projects (Dsc)
# of Projects (Asc)
1.
KITAMURA Shigeyuki
(40136057)
# of Collaborated Projects:
7 results
# of Collaborated Products:
0 results
2.
SUGIHARA Kazumi
(20271067)
# of Collaborated Projects:
6 results
# of Collaborated Products:
0 results
3.
OHTA Shigeru
(60160503)
# of Collaborated Projects:
5 results
# of Collaborated Products:
0 results
4.
ARIZONO Koji
(70128148)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
5.
松井 三郎
(90092808)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
6.
森 千里
(90174375)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
7.
田辺 信介
(60116952)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
8.
井口 泰泉
(90128588)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
9.
森澤 眞輔
(50026340)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
10.
NAKAMURA Shigenobu
(30026843)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
11.
WATANABE Hiromitu
(00034653)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
12.
YAMASAKI Kazuo
(00034017)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
13.
KOTAKE Yaichiro
(20335649)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
14.
TATSUMI Kiyoshi
(90037581)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
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