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YOSHIHARA Shinichi
吉原 新一
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Alternative Names
YOSHIHARA/SHIN'ICHI 吉原 新一
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Researcher Number
00037607
Other IDs
Affiliation (based on the past Project Information)
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2004: 広島国際大学, 薬学部, 教授
2002 – 2003: 広島大学, 大学院・医歯薬学総合研究科, 助教授
1998 – 2001: 広島大学, 医学部, 助教授
1986 – 1987: 広島大学, 医学部, 助教授
Review Section/Research Field
Principal Investigator
Science and Engineering
/
Environmental pharmacy
Except Principal Investigator
医薬分子機能学
/
Neurochemistry/Neuropharmacology
/
Science and Engineering
/
Environmental pharmacy
/
Biological pharmacy
Keywords
Principal Investigator
エストロゲン活性 / 代謝的活性化 / ビスフェノールA / 異物代謝酵素 / 異物(薬物)代謝酵素 / アルキルフェノール / 内分泌撹乱物質 / 異物代謝 / アルキルフェノール類 / ベンゾフェノン類
…
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/ 抗アンドロゲン活性 / プロエストロゲン / フェンチオン / 2-ニトロフルオレン / 内分泌攪乱物質 / 大豆イソフラボン / 内分泌攪乱化学物質 / ゲニステイン / バイオカニンA / ヒトP450 / ラット肝S9 / 内分泌撹乱化学物質 / オクチルフェノール / Endocrine disrupting chemicals / Estrogenicity / Xenobiotic metabolizing enzymes / Metabolic activation / Bisphenol A / Alkylphenols / Genistein / Biochanin A
…
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Except Principal Investigator
パーキンソン病 / Parkinson's disease / テトラヒドロイソキノリン / パーキンソン病発症物質 / ドーパミン神経 / 内分泌撹乱物質 / パーキンソン病防御物質 / 細胞培養 / tetrahydroisoquinoline / Parkinson's disease causing substance / 1MeTIQ / 環境リスク / 国際シンポジウム / 毒性メカニズム / 人体汚染 / 野生生物汚染 / 代謝機構 / バイオアッセイ・バイオマーカー / 人体影響 / バイオアッセイ / DNAマイクロアレイ / Parkinson's disease cpreventing substance / dopaminergic neuron / cell culture / 早期診断技術 / アルデヒドオキシターゼ / アルデヒドオキシダーゼ / early marker / aldehydeoxidase / 内分泌撹乱前駆物質 / エストロゲン / 代謝的活性化 / 薬物代謝酵素 / トランスースチルベン / ビフェニール / ビテロゲニン / トランス-スチルベン / トランスースチルベンオキシド / endocrine disruptor / proestrogen / estrogen / metabolic activation / vitellogenin / trans-stilbene / biphenyl / drug metabolizing enzyme / 神経毒 / ディファレンシャルディスプレイ / cDNAマイクロアレイ / アポトーシス関連遺伝子 / テトラハイドロイソキノリン / NMDAレセプター / アポトーシス / neurotoxin / differential display / apoptosis / cDNA microaray / サルゾリノール / 代謝変換 / パーキンソニズム / 1ベンジルTIQ / ミトコンドリア呼吸鎖阻害 / 細胞培養系 / tetrahydroisogunoline / anti-parkinsonian drug / structure-activity relationship / 新電子伝達系 / フラビン酵素 / アルデヒド酸化酵素 / xanthine oxidase / NADPH-cytochrome c reductase / lipoamide clehydrogenase / 薬物代謝 / xanthine cehydrogenace / lipoamide dehydrogenase / ヒドロキサム酸還元 / 酵素阻害 / N-アリル脂肪族ヒドロキサム酸 / menadione / new electron transfer system / aldehyde oxidase / flavin enzyme / drug metabolism / drug-reducing activity / rabbit / guinea pig
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Research Projects
(
9
results)
Research Products
(
1
results)
Co-Researchers
(
14
People)
Project Start Year (Newest)
Project Start Year (Oldest)
Development of anti-parkinsonian drug using structure-activity relationship
Principal Investigator
OHTA Shigeru
Project Period (FY)
2002 – 2003
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
医薬分子機能学
Research Institution
HIROSHIMA UNIVERSITY
内分泌攪乱物質並びにその前駆物質の代謝変換とホルモン作用の修飾
Principal Investigator
Principal Investigator
吉原 新一
Project Period (FY)
2001 – 2003
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Review Section
Science and Engineering
Research Institution
Hiroshima University
内分泌攪乱物質の環境リスク
Principal Investigator
松井 三郎
Project Period (FY)
2000 – 2004
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Review Section
Science and Engineering
Research Institution
Kyoto University
Research for the Parkinson's disease related proteins using endogenous neurotoxins
Principal Investigator
OHTA Shigeru
Project Period (FY)
2000 – 2001
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Neurochemistry/Neuropharmacology
Research Institution
HIROSHIMA UNIVERSITY
Metabolic Modulation of Estrogenicity of Endocrine Disrupting Chemicals by Cytochrome P450 in Human and Rat Livers
Principal Investigator
Principal Investigator
YOSHIHARA Shin'ichi
Project Period (FY)
2000 – 2001
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Environmental pharmacy
Research Institution
HIROSHIMA UNIVERSITY
Metabolism and endocrine disrupting action of environmental pollutants
Principal Investigator
KITAMURA Shigeyuki
Project Period (FY)
1999 – 2000
Research Category
Grant-in-Aid for Scientific Research (B).
Research Field
Environmental pharmacy
Research Institution
Hiroshima University School of Medicine
Investigation of Parkinson's disease causing substances
Principal Investigator
OHTA Shigeru
Project Period (FY)
1998 – 1999
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
医薬分子機能学
Research Institution
Hiroshima University
Early markers of Parkinson's disease
Principal Investigator
OHTA Shigeru
Project Period (FY)
1998 – 1999
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Neurochemistry/Neuropharmacology
Research Institution
Hiroshima University
Studies on Intra-cellular New Electron Transfer Systems Containing Aldehyde Oxidase as a Component.
Principal Investigator
TATSUMI Kiyoshi
Project Period (FY)
1985 – 1987
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
Biological pharmacy
Research Institution
HIROSHIMA UNIVERSITY
All
2005
All
Journal Article
[Journal Article] Comparative Study of the Endocrine-disrupting Activity of Bisphenol A and 19 Related Compounds.
2005
Author(s)
S.Kitamura, S.Yoshihara, et al.
Journal Title
Toxicological Sciences (In press)
Data Source
KAKENHI-PROJECT-12055101
# of Projects (Dsc)
# of Projects (Asc)
1.
KITAMURA Shigeyuki
(40136057)
# of Collaborated Projects:
7 results
# of Collaborated Products:
0 results
2.
SUGIHARA Kazumi
(20271067)
# of Collaborated Projects:
6 results
# of Collaborated Products:
0 results
3.
OHTA Shigeru
(60160503)
# of Collaborated Projects:
5 results
# of Collaborated Products:
0 results
4.
ARIZONO Koji
(70128148)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
5.
松井 三郎
(90092808)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
6.
森 千里
(90174375)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
7.
田辺 信介
(60116952)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
8.
井口 泰泉
(90128588)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
9.
森澤 眞輔
(50026340)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
10.
NAKAMURA Shigenobu
(30026843)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
11.
WATANABE Hiromitu
(00034653)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
12.
YAMASAKI Kazuo
(00034017)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
13.
KOTAKE Yaichiro
(20335649)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
14.
TATSUMI Kiyoshi
(90037581)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
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