DOI Takefumi 土井健史

… Alternative Names

土井健文ドイタケフミ

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Researcher Number	00211409
Other IDs
Affiliation (based on the past Project Information) *help	2020 – 2021: 大阪大学, 薬学研究科, 特任教授 2016 – 2020: 大阪大学, 薬学研究科, 教授 2011 – 2016: 大阪大学, 薬学研究科(研究院), 教授 2012: 大阪大学, 薬学研究科, 教授 2008 – 2010: 大阪大学, 大学院・薬学研究科, 教授 … More 1998 – 2009: 大阪大学, 薬学研究科, 教授 1999 – 2004: 大阪大学, 大学院・薬学研究科, 教授 2001: 東京大学, 大学院・薬学研究科, 教授 1991 – 1997: 大阪大学, 薬学部, 助教授 1996: Universversity of Osaka, Associae Professor, 薬学部・薬化学教室, 助教授 1995: 大阪大学, 医学部, 助教授 Less
Review Section/Research Field	Principal Investigator Biological pharmacy / 医薬分子機能学 / 血管生物学 / Medium-sized Section 47:Pharmaceutical sciences and related fields / Biological pharmacy Except Principal Investigator Biological Sciences / Chemical pharmacy / Basic Section 59040:Nutrition science and health science-related / Eating habits / Circulatory organs internal medicine … More / Circulatory organs internal medicine / Biological pharmacy / General medical chemistry / 内分泌・代謝学 / 内科学一般 / Biological pharmacy / Medical pharmacy / Drug development chemistry Less
Keywords	Principal Investigator スカベンジャー受容体 / USF / ETS-1 / AML-1 / GATA-1 / UT7 / GAPDH / HSP90 / HSP70 / ユビキチン化 … More / 翻訳後修飾 / MCAF1 / SETDB1 / ヒストンメチル化 / 巨核球 / 細胞内局在 / RNAポリメラーゼ / C型肝炎ウイルス / 細胞質ドメイン / エンドサイトーシス / キナーゼ / がん融合遺伝子 / 人工アミノ酸 / クロスリンク / タンパク質間相互作用 / 融合型キナーゼ / がんゲノム / メチル化 / ヒストン修飾 / GM cell / AML / FPD / Platelet Factor 4 / Megakaryocyte / ドミナントネガティブ / クロマチン免疫沈降 / E-box / p21 / 免疫沈降 / RNAi / GM細胞 / 家族性血小板減少症 / 血小板第4因子 / phosphorylation / aggregation / model molecule / scavenger receptor / macrophage / 核酸分子 / ペプチド分子 / 機能ドメイン / アフィニティカラム / NO産生 / LPS / フコイダン / リン酸化 / アグリゲーション / モデル分子 / マクロファージ / タンパク質精製 / ヒストンメチル化酵素 / ヒストンH3 / ヒストンH３ / GABP / SP1 / 血管内皮細胞 / エピジェネティクス / DNAメチル化 / Robo4遺伝子 / 組織特異的遺伝子発現 / OP9 / Hprt ターゲティング法 / ES細胞 / 転写因子 / RUNX1 / 分化 / 遺伝子発現制御 / 血小板 / NS3 / コアタンパク質 / NS5b / バキュロウイルス / Green Fluorescent Protein / モチーフ配列 / 細胞内輸送 / リガンド / 修飾LDL / コラーゲン / ペプチド / リガンド結合ドメイン / アポリポ蛋白質B100 / ヒスチジン / リガンド解離 / ロイシンジッパー / α-ヘリカルコイルドコイル / ペプチド合成 / アポ蛋白質B100 / リジンクラスター / コラーゲン構造 … More Except Principal Investigator コレステロール / 動脈硬化 / スカベンジャー受容体 / 転写因子 / 人工核酸 / BNA / オリゴヌクレオチド / マクロファージ / NFATc / GATA / atherosclerosis / Atherosclerosis / 泡沫細胞 / 遺伝子発現制御 / 遺伝子ネットワーク / 分子代謝学 / LPIN / 核内受容体 / NRF2 / DSCR1 / WTAP / SREBP / オリゴヌクレオチド類縁体 / アンチセンス / ヌクレオシド類縁体 / knockout mice / foam cell / scavenger receptor / macrophage / 接着因子 / リポ蛋白 / 酸素ラジカル / アテローム性動脈硬化 / Scavenger receptor / Macrophage / LDL / 抗酸化剤 / コラーゲン / 炎症 / 血管内皮細胞 / DNA / コンホメーション / デコイ核酸法 / アポトーシス / 転写制御 / 蛋白質-蛋白質相互作用 / 蛋白質の結晶化 / 蛋白質の大量調製 / 巨核球分化 / 分子病態学 / リガンド / PGAM5 / 立体構造解析 / PPAR / NASH / 活性化剤 / SETDB1 / 蛋白質　分解 / PPARα活性化剤 / 翻訳後修飾 / NFATC / TRANSCRIPTINAL FACTORS / ADHESION MOLECULE / ENDOTHELIAL CELL / ATHEORSCLEROSIS / Tie-2 / target transgenic mouse / TNF-a / トロンビン / マイクロアレイ / ラフト / Rac1 / 内皮細胞 / transcription factor / DNA microarray / DNAマイクロアレー / Antigene / Antisense / Synthesis / Artificial nucleic acid / Oligonucleotide analogue / Nucleoside analogue / Sugar conformation / ホスホロアミダート結合 / 酵素耐性 / アンチジーン / 合成 / 糖部立体配座 / Uboiquitination / Proteasome / 分解 / 転写調節 / ユビキチン化 / プロテアソーム / Gene transfection / Cationic liposome / Chemiluminescence / unnatural amino acids / Pyridoxal model compounds / Antisence / Oligonucleotides / Nucleoside Analogs / 非天然型アミノ酸 / オリゴヌクレオシド / 遺伝子導入 / カチオン性リポソーム / 化学発光 / 非天然アミノ酸 / ピリドキサールモデル化合物 / 酸化LDL / ミクログリア / 脳虚血性疾患 / アルツハイマー病 / MATO細胞 / モノクロナール抗体 / アテローム / Cell Adhesion / Cholestrol / Lipoprotein / ノックアウトマウス / apo E knockout / Mato cell / cholesterol / 生体防御 / adhesion molecule / endocytosis / mouse genetics / host defense / lipoprotein / scavenger recepto / microphage / ジーンターゲッティング / 発生工学 / 酵素ラジカル / protein engineering / human genome / antioxidant / modified LDL / Cholesterol / コレステロ-ル / スカベンジャ受容体 / マクロファ-ジ / プロモーター / 遺伝子構造 / ラジカル反応 / シグナル伝達系 / 炎症性サイトカイン / 免疫細胞 / HDAC阻害剤 / スクリーニング系 / 低分子化合物 / 治療薬 / インターロイキン6 / 単球 / 敗血症 / Robo4 / 医療薬剤学 / MRI / SPECT / 抗体 / 腫瘍血管 / 医用・生体画像 / 遺伝子診断 / 遺伝子検出 / ゲノム創薬 / NF-KB / デコイ法 / 遺伝子発見制御 / デコイ核酸 / 核酸類縁体 / 染色体凝縮 / 3次元構造 / 蛋白質の細胞内局在 / トロンボポエチン刺激 / 蛋白質の大量生産 / 蛋白質の細胞内分布 Less

Analysis of cancer specific signaling cascade by in vivo protein photo-cross-linking approachPrincipal Investigator
- Principal Investigator
  
  DOI Takefumi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Osaka University
Development of NASH therapeutics by regulating energy expenditure and inflammation through the lipid sensor PPAR
- Principal Investigator
  
  Keisuke TACHIBANA
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Osaka University
Analysis of the transcriptional regulatory mechanism of nuclear receptors via posttranslational modification of the nuclear receptors and localization of the interacting factors
- Principal Investigator
  
  Keisuke Tachibana
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Eating habits
- Research Institution
  Osaka University
Analysis of molecular mechanism regulating enzyme function of histone methylation enzyme SETDB1Principal Investigator
- Principal Investigator
  
  DOI Takefumi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Osaka University
Novel anti-sepsis strategy targeting the endothelial cell-specific receptor Robo4
- Principal Investigator
  
  Okada Yoshiaki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Osaka University
Innovative Drug Development for Histone MethylasePrincipal Investigator
- Principal Investigator
  
  DOI Takefumi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Osaka University
Regulation mechanisms involved in tissue-specific gene expressionPrincipal Investigator
- Principal Investigator
  
  DOI Takefumi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Osaka University
Construction of antibody-based molecular imaging techniques to analyze a development of tumor angiogenesis.
- Principal Investigator
  
  MUKAI Yohei
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
- Research Field
  
  Medical pharmacy
- Research Institution
  Osaka University
Transcription factors regulating normal and pathological platelet differentiationPrincipal Investigator
- Principal Investigator
  
  DOI Takefumi
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Osaka University
Development of artificial nucleic acid conjugates as base materials for genome-based drug discovery and DNA-based diagnostics
- Principal Investigator
  
  IMANISHI Takeshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Osaka University
遺伝子ネットワーク解明に向けた高機能性人工デコイ核酸の開発
- Principal Investigator
  
  今西武
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Analyses of transcription factors related to megakaryocyte differentiation and maturation.Principal Investigator
- Principal Investigator
  
  DOI Takefumi
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Osaka University
遺伝子ネットワーク解明に向けた高機能性人工デコイ核酸の開発
- Principal Investigator
  
  今西武
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Activation of Arterial Wall Cells during Atherogenesis : A study using a in vitor co-culture model system
- Principal Investigator
  
  KODAMA Tatsuhiko
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  The University of Tokyo
遺伝子ネットワーク解明に向けた高機能性人工デコイ核酸の開発
- Principal Investigator
  
  今西武
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
造血幹細胞から巨核球への分化に関わる蛋白質群の3次元構造と機能
- Principal Investigator
  
  山縣ゆり子
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
遺伝子ネットワーク解明に向けた高機能性人工デコイ核酸の開発
- Principal Investigator
  
  今西武
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Transcriptome Analysis of Atherosclerosis
- Principal Investigator
  
  KODAMA Tatsuhiko
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  The University of Tokyo
Study to develop novel genomic drugs by using superfunctional oligonucleotide analogues
- Principal Investigator
  
  IMANISHI Takeshi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Osaka University
造血幹細胞から巨核球への分化に関わる蛋白質群の3次元構造と機能
- Principal Investigator
  
  山縣ゆり子
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
C型肝炎ウイルスの増殖機構の解明Principal Investigator
- Principal Investigator
  
  土井健史
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  医薬分子機能学
- Research Institution
  Osaka University
Design and Syntheses of Biologically Functional Molecules Based on the Mechanisms of Life
- Principal Investigator
  
  IMANISHI Takeshi
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Osaka University
Regulation of transcription factors by nuclear degradation
- Principal Investigator
  
  SATO Ryuichiro
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  THE UNIVERSITY OF TOKYO
Synthesis and application of functional domain of macrophage scavenger receptorPrincipal Investigator
- Principal Investigator
  
  DOI Takefumi
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  医薬分子機能学
- Research Institution
  Osaka University
C型肝炎ウイルスのRNAポリメラーゼを標的にしたC型肝炎治療薬の開発研究Principal Investigator
- Principal Investigator
  
  土井健史
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  医薬分子機能学
- Research Institution
  Osaka University
A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection
- Principal Investigator
  
  KODAMA Tatsuhiko
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  General medical chemistry
- Research Institution
  Research Center for Advanced Science and Technology University of Tokyo
マクロファージスカベンジャー受容体の細胞内輸送に関与する機能配列の探究Principal Investigator
- Principal Investigator
  
  土井健史
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Osaka University
Macrophage scavenger receptors and atherosclerosis
- Principal Investigator
  
  KODAMA Tatsuhiko
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Research Center for Advanced Sclence and Technology University of Tokyo
スカベンジャー受容体と相互作用するアポリポ蛋白質の解析と動脈硬化抑止への試みPrincipal Investigator
- Principal Investigator
  
  土井健史
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  血管生物学
- Research Institution
  Osaka University
Scavenger receptor deficient mice and macrophage function
- Principal Investigator
  
  KODAMA Tatsuhiko
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  University of Tokyo
スカベンジャー受容体のリガンド解離機構の研究Principal Investigator
- Principal Investigator
  
  土井健史
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  血管生物学
- Research Institution
  Osaka University
Structure and function of macrophage scavenger receptors
- Principal Investigator
  
  KODAMA Tatsuhiko
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  University of Tokyo
スカベンジャー受容体のリガンド結合領域の構造解析Principal Investigator
- Principal Investigator
  
  土井健史
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  血管生物学
- Research Institution
  Osaka University
Molecular biology of macrophage scavenger receptors and modified LDL;
- Principal Investigator
  
  KODAMA Tatsuhiko
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  UNIVERSITY OF TOKYO

[Journal Article] Exploring Compounds to be used as Cosmetic Agents that Activate Peroxisome Proliferator‐Activated Receptor Alpha2022
- Author(s)
  Tachibana Keisuke、Fukuda Syohei、Fukushima Jun、Ishimoto Kenji、Sakata Masahiro、Nishimori Yasutomo、Doi Takefumi
- Journal Title
  
  International Journal of Cosmetic Science
  
  Volume: - Issue: 2 Pages: 189-200
- DOI
  10.1111/ics.12767
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H03190, KAKENHI-PROJECT-21H03354
[Journal Article] Structural Basis for PPARα Activation by 1H-pyrazolo-[3,4-b]pyridine Derivatives.2020
- Author(s)
  Yoshida T, Oki H, Doi M, Fukuda S, Yuzuriha T, Tabata R, Ishimoto K, Kawahara K, Ohkubo T, Miyachi H, Doi T, Tachibana K.
- Journal Title
  
  Scientific Reports
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H03190
[Journal Article] Cupid and Psyche system for the diagnosis and treatment of advanced cancer2019
- Author(s)
  Sugiyama A, Kawamura T, Tanaka T, Doi H, Yamashita T, Shinoda K, Fujitani H, Yamatsugu K, Shimizu Y, Tatsumi T, Takahashi K, Kanai M, Mizohata E, Kawato T, Doi T, Inoue T, Kodama T.
- Journal Title
  
  Proceedings of the Japan Academy, Series B
  
  Volume: 95 Issue: 10 Pages: 602-611
- DOI
  10.2183/pjab.95.041
- NAID
  130007760701
- ISSN
  0386-2208, 1349-2896
- Year and Date
  2019-12-11
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K22496, KAKENHI-PROJECT-18H03548
[Journal Article] Development of a Ligand Screening Tool Using Full-Length Human Peroxisome Proliferator-Activated Receptor-Expressing Cell Lines to Ameliorate Metabolic Syndrome2019
- Author(s)
  Tachibana Keisuke、Ishimoto Kenji、Takahashi Rika、Kadono Hirokazu、Awaji Takuya、Yuzuriha Tomohiro、Tanaka Toshiya、Hamakubo Takao、Sakai Juro、Kodama Tatsuhiko、Aoki Shunji、Doi Takefumi
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 67 Issue: 3 Pages: 199-202
- DOI
  10.1248/cpb.c18-00627
- NAID
  130007605823
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2019-03-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H03190, KAKENHI-PROJECT-16K13044
[Journal Article] The CalcR-PKA-Yap1 Axis Is Critical for Maintaining Quiescence in Muscle Stem Cells.2019
- Author(s)
  Zhang L, Noguchi YT, Nakayama H, Kaji T, Tsujikawa K, Ikemoto-Uezumi M, Uezumi A, Okada Y, Doi T, Watanabe S, Braun T, Fujio Y, Fukada SI.
- Journal Title
  
  Cell Rep
  
  Volume: 19 Issue: 8 Pages: 2154-63
- DOI
  10.1016/j.celrep.2019.10.057
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19740, KAKENHI-PROJECT-19K22496, KAKENHI-PROJECT-18H02603, KAKENHI-PROJECT-19H04000, KAKENHI-PROJECT-18K19545
[Journal Article] Lipin-1 is a novel substrate of protein phosphatase PGAM52019
- Author(s)
  Okuno Hiroko、Okuzono Haruna、Hayase Ayaka、Kumagai Fumiko、Tanii Shohei、Hino Nobumasa、Okada Yoshiaki、Tachibana Keisuke、Doi Takefumi、Ishimoto Kenji
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 509 Issue: 4 Pages: 886-891
- DOI
  10.1016/j.bbrc.2019.01.031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19403, KAKENHI-PROJECT-18H03190, KAKENHI-PROJECT-17K19487
[Journal Article] Structural development of 1H-pyrazolo-[3,4-b]pyridine-4-carboxylic acid derivatives as human peroxisome proliferator-activated receptor alpha (PPARα)-selective agonists2019
- Author(s)
  Miyachi Hiroyuki、Yuzuriha Tomohiro、Tabata Ryotaro、Fukuda Syohei、Nunomura Kazuto、Lin Bangzhong、Kobayashi Tadayuki、Ishimoto Kenji、Doi Takefumi、Tachibana Keisuke
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 29 Issue: 16 Pages: 2124-2128
- DOI
  10.1016/j.bmcl.2019.06.062
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H03190
[Journal Article] Discovery of peroxisome proliferator?activated receptor α (PPARα) activators with a ligand-screening system using a human PPARα-expressing cell line2018
- Author(s)
  Tachibana Keisuke、Yuzuriha Tomohiro、Tabata Ryotaro、Fukuda Syohei、Maegawa Takashi、Takahashi Rika、Tanimoto Keiichi、Tsujino Hirofumi、Nunomura Kazuto、Lin Bangzhong、Matsuura Yoshiharu、Tanaka Toshiya、Hamakubo Takao、Sakai Juro、Kodama Tatsuhiko、Kobayashi Tadayuki、Ishimoto Kenji、Miyachi Hiroyuki、Doi Takefumi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 293 Issue: 26 Pages: 10333-10343
- DOI
  10.1074/jbc.ra118.002077
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H03190, KAKENHI-PROJECT-16K13044, KAKENHI-PROJECT-16H06390
[Journal Article] Tumor Necrosis Factor α Induces the Expression of the Endothelial Cell-Specific Receptor Roundabout4 through the Nuclear Factor-κB Pathway2017
- Author(s)
  Tanaka T, Maekawa N, Kashio T, Izawa K, Ishiba R, Shirakura K, Ishimoto K, Hino N, Aird WC, Doi T, Okada Y.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 40 Issue: 4 Pages: 504-509
- DOI
  10.1248/bpb.b16-00938
- NAID
  130005530067
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293014, KAKENHI-PROJECT-16K21142
[Journal Article] IL-1β-induced downregulation of the multifunctional PDZ adaptor PDZK1 is attenuated by ERK inhibition, RXRα or PPARα stimulation in enterocytes.2017
- Author(s)
  Luo M, Yeruva S, Liu Y, Chodisetti G, Riederer B, Menon MB, Tachibana K, Doi T, Seidler U
- Journal Title
  
  Frontiers in Physiology
  
  Volume: 8 Pages: 61-61
- DOI
  10.3389/fphys.2017.00061
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02896
[Journal Article] Degradation of human Lipin-1 by BTRC E3 ubiquitin ligase2017
- Author(s)
  Ishimoto Kenji、Hayase Ayaka、Kumagai Fumiko、Kawai Megumi、Okuno Hiroko、Hino Nobumasa、Okada Yoshiaki、Kawamura Takeshi、Tanaka Toshiya、Hamakubo Takao、Sakai Juro、Kodama Tatsuhiko、Tachibana Keisuke、Doi Takefumi
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 488 Issue: 1 Pages: 159-164
- DOI
  10.1016/j.bbrc.2017.04.159
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19487, KAKENHI-PROJECT-16H06390, KAKENHI-PUBLICLY-16H01382, KAKENHI-PROJECT-15H02896, KAKENHI-PROJECT-16F16725, KAKENHI-PROJECT-16K13042, KAKENHI-PROJECT-16K21142
[Journal Article] Adenovirus vector-based incorporation of a photo-cross-linkable amino acid into proteins in human primary cells and cancerous cell lines.2016
- Author(s)
  Kita A, Hino N, Higashi S, Hirota K, Narumi R, Adachi J, Takafuji K, Ishimoto K, Okada Y, Sakamoto K, Tomonaga T, Takashima S, Mizuguchi H, Doi T.
- Journal Title
  
  Sci Rep
  
  Volume: 6 Issue: 1 Pages: 36946-36946
- DOI
  10.1038/srep36946
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04820, KAKENHI-PROJECT-26291035, KAKENHI-PROJECT-26293014, KAKENHI-PROJECT-16K21142
[Journal Article] Ubiquitination of Lysine 867 of the Human SETDB1 Protein Upregulates Its Histone H3 Lysine 9 (H3K9) Methyltransferase Activity.2016
- Author(s)
  Ishimoto K, Kawamata N, Uchihara Y, Okubo M, Fujimoto R, Gotoh E, Kakinouchi K, Mizohata E, Hino N, Okada Y, Mochizuki Y, Tanaka T, Hamakubo T, Sakai J, Kodama T, Inoue T, Tachibana K, Doi T
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 10 Pages: e0165766-e0165766
- DOI
  10.1371/journal.pone.0165766
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H02896, KAKENHI-PROJECT-15H04644, KAKENHI-PROJECT-25282230, KAKENHI-PROJECT-26293014, KAKENHI-PROJECT-16K21142, KAKENHI-PROJECT-16H06390
[Journal Article] Efficacy and safety evaluation of claudin-4-targeted antitumor therapy using a human and mouse cross-reactive monoclonal antibody.2016
- Author(s)
  Hashimoto Y, Kawahigashi Y, Hata T, Li X, Watari A, Tada M, Ishii-Watabe A, Okada Y, Doi T, Fukasawa M, Kuniyasu H, Yagi K, Kondoh M
- Journal Title
  
  Pharmacol Res Perspect
  
  Volume: 4 Issue: 5
- DOI
  10.1002/prp2.266
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05164, KAKENHI-PROJECT-26293014, KAKENHI-PROJECT-15J10065
[Journal Article] Generation and characterization of a human-mouse chimeric antibody against the extracellular domain of claudin-1 for cancer therapy using a mouse model.2016
- Author(s)
  Hashimoto Y, Tada M, Iida M, Nagase S, Hata T, Watari A, Okada Y, Doi T, Fukasawa M, Yagi K, Kondoh M.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 477(1) Issue: 1 Pages: 91-95
- DOI
  10.1016/j.bbrc.2016.06.025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293014, KAKENHI-PROJECT-16K08370, KAKENHI-PROJECT-15J10065
[Journal Article] Analysis of the subcellular localization of the human histone methyltransferase SETDB12015
- Author(s)
  Tachibana K, Gotoh E, Kawamata N, Ishimoto K, Uchihara Y, Iwanari H, Sugiyama A, Kawamura T, Mochizuki Y, Tanaka T, Sakai J, Hamakubo T, Kodama T, Doi T.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 465 Issue: 4 Pages: 725-731
- DOI
  10.1016/j.bbrc.2015.08.065
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22229009, KAKENHI-PROJECT-25220205, KAKENHI-PROJECT-15H02896, KAKENHI-PROJECT-15H04644, KAKENHI-PROJECT-26560395, KAKENHI-PROJECT-25860253, KAKENHI-PROJECT-26870346, KAKENHI-PUBLICLY-26116708
[Journal Article] Expression of the Robo4 receptor in endothelial cells is regulated by two AP-1 protein complexes.2015
- Author(s)
  Okada Y, Naruse H, Tanaka T, Funahashi N, Regan ER, Yamakawa K, Hino N, Ishimoto K, Doi T, Aird WC.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 467(4) Issue: 4 Pages: 987-991
- DOI
  10.1016/j.bbrc.2015.10.029
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K16537, KAKENHI-PROJECT-26870346, KAKENHI-PROJECT-26293014
[Journal Article] Endothelial cell-specific expression of roundabout 4 is regulated by differential DNA methylation of the proximal promoter2014
- Author(s)
  Okada, Y., Funahashi, N., Tanaka, T., Nishiyama, Y., Yuan, L., Shirakura, K., Turjman, A. S., Kano, Y., Naruse, H., Suzuki, A., Sakai, M., Zhixia, J., Kitajima, K., Ishimoto, K., Hino, N., Kondoh, M., Mukai, Y., Nakagawa, S., Garcia-Cardena, G., Aird, W. C., Doi, T.
- Journal Title
  
  Arterioscler Thromb. Vasc. Biol.
  
  Volume: 34 Issue: 7 Pages: 1531-1538
- DOI
  10.1161/atvbaha.114.303818
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670023, KAKENHI-PROJECT-25670056, KAKENHI-PROJECT-26293014, KAKENHI-PROJECT-26713007, KAKENHI-PROJECT-26870346
[Journal Article] An induced pluripotent stem cell-mediated and integration-free factor VIII expression system2013
- Author(s)
  Yakura Y, Ishihara C, Kurosaki H, Kazuki Y, Komatsu N, Okada Y, Doi T, Takeya H, Oshimura M.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: Vol.431 Pages: 336-341
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659040
[Journal Article] Embryonic stem cell differentiation system for evaluating gene functions involved in physiological megakaryocytic differentiation2012
- Author(s)
  Okada Y, Yonekura M, Watanabe M, Nakai T, Wakimura A, Shimizu M, Kamikawa Y, Kitayama M, Kitajima K, Aird WC, Doi T
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: Vol.419 Pages: 477-481
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659040
[Journal Article] New Protein Purification System Using Gold-Magnetic Beads and a Novel Peptide Tag, "the Methionine Tag"2011
- Author(s)
  Okada Y, Takano TY, Kobayashi N, Hayashi A, Yonekura M, NishiyamaY, Abe T, Yoshida T, Yamamoto TA, Seino S, Doi T
- Journal Title
  
  Bioconjug. Chem
  
  Volume: Vol.22 Pages: 887-893
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659040
[Journal Article] Multiple ETS Family Proteins Regulate PF4 GeneExpression by Binding to the Same ETS Binding Site2011
- Author(s)
  Okada Y, Nobori H, Shimizu M, Watanabe M, Yonekura M, Nakai T, Kamikawa Y, Wakimura A, Funahashi N, Naruse H, Watanabe A, Yamasaki D, Fukada S, Yasui K, Matsumoto K, Sato T, Kitajima K, Nakano T, Aird WC, Doi T
- Journal Title
  
  PLoS One
  
  Volume: Vol.6 Pages: 1-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659040
[Journal Article] in vitroとin vivoで異なるレポータージーンアッセイの結果2010
- Author(s)
  岡田欣晃、土井健史
- Journal Title
  
  生産と技術 62巻
  
  Pages: 51-56
- NAID
  40017231022
- Data Source
  KAKENHI-PROJECT-19390022
[Journal Article] in vitroとin vivoで異なるレポータージーンアッセイの結果2010
- Author(s)
  岡田欣晃、土井健史
- Journal Title
  
  生産と技術 62
  
  Pages: 51-56
- NAID
  40017231022
- Data Source
  KAKENHI-PROJECT-20200017
[Journal Article] 血管内皮細胞の遺伝子発現制御研究からみたin vivoプロモーター解析の重要性2009
- Author(s)
  岡田欣晃、土井健史
- Journal Title
  
  生化学 81
  
  Pages: 117-121
- NAID
  10024915912
- Data Source
  KAKENHI-PROJECT-20200017
[Journal Article] 血管内皮細胞の遺伝子発現制御研究からみたin vivoプロモーター解析の重要性2009
- Author(s)
  岡田欣晃, 土井健史
- Journal Title
  
  生化学 80巻
  
  Pages: 117-121
- NAID
  10024915912
- Data Source
  KAKENHI-PROJECT-19390022
[Journal Article] A GABP-binding element in the Robo 4 promoter is necessary for endothelial expression in vivo2008
- Author(s)
  Okada Y, Jin E, Nikolova-Krstevski V, Yano K, Liu J, Beeler D, Spokes K, Kitayama M, Funahashi N, Doi T, Janes L, Minami T, Oettgen P, Aird WC.
- Journal Title
  
  Blood 112
  
  Pages: 2336-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20200017
[Journal Article] Ligand-independent assembly of purified soluble magic roundabout (Robo4), a tumor-specific endothelial marker2008
- Author(s)
  Yoshikawa M, Mukai Y, Okada Y, Yoshioka Y, Tsunoda S, Tsutsumi Y, Okada N, Aird WC, Doi T, NakaEawa S.
- Journal Title
  
  Protein Expr Purif. 61
  
  Pages: 78-82
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20200017
[Journal Article] A GABP-binding element in the Robo4 promoter is necessary for endothelial expression in vivo2008
- Author(s)
  Y. Okada, E. Jin, V. Nikolova-Krstevski, K. Yano, J. Liu, D. Beeler, K. Spokes, M. Kitayama, N. Funahashi, T. Doi, L. Janes, T. Minami, P. Oettgen, W.C. Aird
- Journal Title
  
  Blood Vol.112
  
  Pages: 2336-2339
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390022
[Journal Article] A GABP-binding element in the Robo4 promoter is necessary for endothelial expression in vivo.2008
- Author(s)
  Okada Y, Jin E, Nikolova-Krstevski V, Yano K, Liu J, Beeler D, Spokes K, Kitayama M, Funahashi N, Doi T, Janes L, Minami T, Oettgen P, Aird WC.
- Journal Title
  
  Blood. 112(6)
  
  Pages: 2336-2339
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20200017
[Journal Article] A Three-Kilobase Fragment of the Human Robo4 Promoter Directs Cell Type-Specific Expression in Endothelium2007
- Author(s)
  Y. Okada, K. Yano, E. Jin, N. Funahashi, M. Kitayama, T. Doi, K. Spokes, D.L. Beeler, S-C. Shih, H. Okada, T.A. Danilov, E. Maynard, T. Minami, P. Oettgen, W.C. Aird
- Journal Title
  
  Circulation Research Vol.100
  
  Pages: 1712-1722
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390022
[Journal Article] 巨核球・血小板系列特異的遺伝子発現制御に関与する転写因子群の解析2005
- Author(s)
  土井健史
- Journal Title
  
  生産と技術 57・1
  
  Pages: 38-41
- NAID
  40006607488
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390022
[Journal Article] 巨核球・血小板系列の遺伝子発現に関与する転写因子2005
- Author(s)
  土井健史
- Journal Title
  
  薬学雑誌 125・9
  
  Pages: 685-697
- NAID
  110004042056
- Data Source
  KAKENHI-PROJECT-16390022
[Journal Article] 巨核球・血小板系列の遺伝子発現に閲与する転写因子2005
- Author(s)
  土井健史
- Journal Title
  
  薬学雑誌 125・9
  
  Pages: 685-697
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390022
[Journal Article] Analyses of transcription factors regulating megakaryocyte-specific gene expression2005
- Author(s)
  Takefumi Doi
- Journal Title
  
  Seisan to Gijutsu 57(1)
  
  Pages: 38-41
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390022
[Journal Article] 巨核球・血小板系列特異的遺伝子発現制御に関与する転写因子群の解析2005
- Author(s)
  土井健史, 岡田欣晃
- Journal Title
  
  生産と技術 57・1
  
  Pages: 38-41
- NAID
  40006607488
- Data Source
  KAKENHI-PROJECT-16390022
[Journal Article] Transcription Factors Responsible for Megakaryocyte-specific Gene Expression2005
- Author(s)
  Takefumi Doi
- Journal Title
  
  Yakugaku Zasshi 125(9)
  
  Pages: 685-697
- NAID
  110004042056
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390022
[Journal Article] Upstream stimulatory factors stimulate transcription through E-box motifs in the PF4 gene in megakaryocytes.2004
- Author(s)
  Y.Okada, E.Matsuura, Z.Tozuka, R.Nagai, A.Watanabe, K.Matstumoto, K.Yasui, R.W.Jackman, T.Nakano, T.Doi
- Journal Title
  
  Blood 104・7
  
  Pages: 2027-2034
- Data Source
  KAKENHI-PROJECT-16390022
[Patent] ＰＰＡＲα転写活性化剤およびその医薬用途2021
- Inventor(s)
  土井健史,橘敬祐,赤井周司,吉田卓也,森江俊哉,辻川和丈ら
- Industrial Property Rights Holder
  土井健史,橘敬祐,赤井周司,吉田卓也,森江俊哉,辻川和丈ら
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-095378
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-18H03190
[Patent] ＰＰＡＲα活性化剤2021
- Inventor(s)
  土井健史、橘敬祐、福田昭平、福島純、阪田昌弘
- Industrial Property Rights Holder
  土井健史、橘敬祐、福田昭平、福島純、阪田昌弘
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-162499
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-18H03190
[Patent] ピラゾロピリジン誘導体およびその使用2016
- Inventor(s)
  土井健史, 橘敬祐, 小林直之, 杠智博, 石本憲司, 宮地弘幸
- Industrial Property Rights Holder
  国立大学法人大阪大学、国立大学法人岡山大学
- Industrial Property Rights Type
  特許
- Filing Date
  2016-11-11
- Overseas
- Data Source
  KAKENHI-PROJECT-15H02896
[Presentation] DNA脱メチル化関連酵素TET1の刺激依存的翻訳後修飾による活性調節2021
- Author(s)
  齋藤里緒，喜多絢海，谷口健吾，和島壮一，石田莉子，原田和生，樋野展正，土井健史
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K22496
[Presentation] がん変異に影響されるFBXW7αの新規タンパク質間相互作用の探索2021
- Author(s)
  山本真実，重松知沙，山本紘義，川端猛，鳴海良平，足立淳，栗栖源嗣，樋野展正，土井健史
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K22496
[Presentation] タンパク質間相互作用界面の同定を可能にする新規光架橋性人工アミノ酸の開発2021
- Author(s)
  高田理彩，樋野展正，山口卓男，深田宗一朗，土井健史
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K22496
[Presentation] DNA脱メチル化関連酵素TET1の刺激依存的活性調節の分子機構2021
- Author(s)
  石田莉子，喜多絢海，谷口健吾，和島壮一，斎藤里緒，原田和生，樋野展正，土井健史
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K22496
[Presentation] 新規PPARα作動薬の創出とその構造展開2020
- Author(s)
  宮地弘幸、布村一人、林邦忠、土井健史、橘敬祐
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18H03190
[Presentation] DNA脱メチル化関連酵素TET1の刺激依存的活性調節機構の解明2020
- Author(s)
  和島壮一，喜多絢海，谷口健悟，原田和生，土井健史，樋野展正
- Organizer
  第70回日本薬学会関西支部大会
- Data Source
  KAKENHI-PROJECT-19K22496
[Presentation] 新規PPARα作動薬の創出とその構造展開2020
- Author(s)
  宮地弘幸、布村一人、林邦忠、土井健史、橘敬祐
- Organizer
  日本薬学会　第140年会
- Data Source
  KAKENHI-PROJECT-19K22496
[Presentation] 細胞内光クロスリンク法を利用したSTK11のがん関連相互作用の探索2020
- Author(s)
  山本紘義，重松知沙，川端猛，栗栖源嗣，土井健史，樋野展正
- Organizer
  第70回日本薬学会関西支部大会
- Data Source
  KAKENHI-PROJECT-19K22496
[Presentation] 非アルコール性脂肪肝炎（NASH）克服を目指した核内受容体PPARαの新規活性化剤の創製2020
- Author(s)
  橘敬祐, 土井健史
- Organizer
  第93回日本薬理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-18H03190
[Presentation] 細胞内光クロスリンク法を用いたがん関連因子FBXW7αの相互作用解析2020
- Author(s)
  重松知沙，山本紘義，川端猛，栗栖源嗣，土井健史，樋野展正
- Organizer
  第70回日本薬学会関西支部大会
- Data Source
  KAKENHI-PROJECT-19K22496
[Presentation] 皮膚機能を改善する核内受容体PPARα活性化成分の探索2019
- Author(s)
  福田昭平, 橘敬祐, 福島純, 阪田昌弘, 西森康友, 土井健史
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K22496
[Presentation] DNA脱メチル化関連酵素TET1の活性調節機構の解析2019
- Author(s)
  Jeremia Febrian, 喜多絢海, 谷口健悟, 和島壮一, 斎藤里緒, 高島成二, 土井健史, 樋野展正
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K22496
[Presentation] 皮膚機能を改善する核内受容体PPARα活性化成分の探索2019
- Author(s)
  福田昭平、橘敬祐、福島純、阪田昌弘、西森康友、土井健史
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18H03190
[Presentation] 細胞内光クロスリンク法を利用した新規肺がん治療標的の探索2019
- Author(s)
  山本紘義，向山樹，鳴海良平，重松知沙，山本真実，足立淳，土井健史，樋野展正
- Organizer
  日本ケミカルバイオロジー学会第14回年会
- Data Source
  KAKENHI-PROJECT-19K22496
[Presentation] 細胞内光クロスリンク法によるDNA脱メチル化酵素TET1の活性調節因子の探索2019
- Author(s)
  和島壮一，喜多絢海，谷口健吾，Jeremia Febrian，齋藤里緒，高島成二，土井健史，樋野展正
- Organizer
  日本ケミカルバイオロジー学会第14回年会
- Data Source
  KAKENHI-PROJECT-19K22496
[Presentation] 細胞内光クロスリンク法を用いたがん特異的タンパク質間相互作用の効率的な解析系の確立2019
- Author(s)
  向山樹, 廣田康二, 鳴海良平，山本紘義，重松知沙，山本真実，足立淳，土井健史，樋野展正
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K22496
[Presentation] 1H-pyrazolo-[3,4-b]pyridine-4-carboxylic acids as human peroxisome proliferator-activated receptor (PPAR) alpha-selective agonists2019
- Author(s)
  Hiroyuki Miyachi, Kazuto Nunomura, Bangzhong Lin,Takefumi Doi, Keisuke Tachibana
- Organizer
  第37回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-18H03190
[Presentation] 生活習慣病治療薬開発を目指した新規PPAR alpha作動薬としてのピラゾロピリジン誘導体の開発2019
- Author(s)
  橘敬祐, 福田昭平, 杠智博, 田畑遼太朗, 布村一人, 林邦忠, 小林直之, 石本憲司, 宮地弘幸, 土井健史
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18H03190
[Presentation] 変異集積表面への光クロスリンカー導入によるがん特異的蛋白質間相互作用の同定2019
- Author(s)
  樋野展正，向山樹，鳴海良平，川端猛，山本紘義，重松知沙，山本真実，栗栖源嗣，足立淳，土井健史_
- Organizer
  日本ケミカルバイオロジー学会第14回年会
- Data Source
  KAKENHI-PROJECT-19K22496
[Presentation] Development Of Novel Non-fibrate Peroxisome Proliferator-activated Receptor Ligand For Treating Nonalcoholic Steatohepatitis2018
- Author(s)
  Keisuke TACHIBANA, Tomohiro YUZURIHA, Ryotaro TABATA, Syohei FUKUDA, Kazuto NUNOMURA, Bangzhong LIN, Tadayuki KOBAYASHI, Masuo KONDOH, Kenji ISHIMOTO, Hiroyuki MIYACHI, Takefumi DOI
- Organizer
  CRS Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03190
[Presentation] 非アルコール性脂肪肝炎（NASH）克服を目指した新規核内受容体PPARα活性化剤の創製2018
- Author(s)
  橘敬祐, 田畑遼太朗, 福田昭平, 布村一人, 土井健史
- Organizer
  先導的学際研究機構創薬サイエンス部門シンポジウム　「我が国が切り拓く難病治療の未来」
- Data Source
  KAKENHI-PROJECT-15H02896
[Presentation] Development of novel non-fibrate PPARα activator for metabolic diseases2018
- Author(s)
  Keisuke TACHIBANA, Tomohiro YUZURIHA, Ryotaro TABATA, Syohei FUKUDA, Kazuto NUNOMURA, Tadayuki KOBAYASHI, Kenji ISHIMOTO, Hiroyuki MIYACHI, Takefumi DOI
- Organizer
  4th International Symposium of Medicinal Sciences
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02896
[Presentation] 脂質異常症治療薬の開発を目指した新規PPARα活性化化合物の薬効と毒性の評価2017
- Author(s)
  田畑遼太朗, 橘敬祐, 杠智博, 前川貴志, 福田昭平, 石本憲司, 小林直之, 田中十志也, 児玉龍彦, 宮地弘幸, 土井健史
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-27
- Data Source
  KAKENHI-PROJECT-15H02896
[Presentation] TNF-αはNF-κB経路を介して血管内皮細胞特異的受容体Robo4の発現を促進する2017
- Author(s)
  前河直樹, 田中亨, 樫尾泰斗, William C. Aird, 岡田欣晃, 土井健史
- Organizer
  日本薬学会第137回年会
- Place of Presentation
  東北大学（宮城）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293014
[Presentation] 核内受容体PPARα発現細胞株を用いたリガンドスクリーニング系の構築と新規活性化剤の探索2017
- Author(s)
  橘敬祐, 田畑遼太朗, 杠智博, 福田昭平, 前川貴志, 石本憲司, 布村一人, 小林直之, 宮地弘幸, 土井健史
- Organizer
  第21回　日本心血管内分泌代謝学会学術総会
- Data Source
  KAKENHI-PROJECT-15H02896
[Presentation] Novel anti-sepsis strategy targeting the endothelial cell-specific receptor Robo42016
- Author(s)
  Yoshiaki Okada, Keisuke Shirakura, Kiichiro Yano, Naoya Shigesada, Yu Fukushima, Ryosuke Ishiba, Taito Kashio, William C. Aird, Takefumi Doi
- Organizer
  第2 回春期特別日本血管生物医学会シンポジウム
- Place of Presentation
  大阪大学微生物病研究所（大阪府）
- Year and Date
  2016-06-03
- Data Source
  KAKENHI-PROJECT-26293014
[Presentation] 3.Roundabout4 suppresses TNFα-induced vascular hyperpermeability via TRAF72016
- Author(s)
  Keisuke Shirakura, Toru Tanaka, William C. Aird, Takefumi Doi, Yoshiaki Okada
- Organizer
  19th International Vascular Biology Meeting
- Place of Presentation
  ボストン（アメリカ）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293014
[Presentation] Robo4が炎症時の血管透過性を制御するメカニズムの解析2016
- Author(s)
  白倉圭佑, William Aird, 岡田欣晃, 土井健史
- Organizer
  第17回 Pharmaco-Hematology シンポジウム
- Place of Presentation
  帝京大学（東京）
- Data Source
  KAKENHI-PROJECT-26293014
[Presentation] Tricellular tight junction を標的とした新規バリア制御技術、angubindin-1 の開発2016
- Author(s)
  山本浩樹, 井口大輔, 早石知浩, Susanne M. KRUG, Michael FROMM, 渡利彰浩, 岡田欣晃, 竹田浩之, 永浜政博, 土井健史, 澤崎達也, 近藤昌夫, 八木清仁
- Organizer
  日本薬学会　第136年会
- Place of Presentation
  横浜（神奈川県）
- Year and Date
  2016-03-28
- Data Source
  KAKENHI-PROJECT-26293014
[Presentation] 心血管イベントの残余リスクの軽減を目指した新規核内受容体PPARα作働薬の開発2016
- Author(s)
  橘敬祐, 杠智博, 田畑遼太朗, 前川貴志, 福田昭平, 石本憲司, 小林直之, 宮地弘幸, 土井健史
- Organizer
  第1回黒潮カンファレンス
- Place of Presentation
  千葉
- Year and Date
  2016-10-22
- Data Source
  KAKENHI-PROJECT-15H02896
[Presentation] 核内受容体PPARαを標的とした新規脂質異常症治療薬の開発2016
- Author(s)
  田畑遼太朗, 橘敬祐, 杠智博, 前川貴志, 福田昭平, 石本憲司, 小林直之, 田中十志也, 児玉龍彦, 宮地弘幸, 土井健史
- Organizer
  第15回次世代を担う若手ファーマ・バイオフォーラム2016
- Place of Presentation
  大阪
- Year and Date
  2016-09-10
- Data Source
  KAKENHI-PROJECT-15H02896
[Presentation] 血管内皮細胞特異的Robo4発現が生み出されるメカニズムの解明2016
- Author(s)
  田中亨, 岡村麻紀, 川端健二, 岡田欣晃, 土井健史
- Organizer
  第17回 Pharmaco-Hematology シンポジウム
- Place of Presentation
  帝京大学（東京）
- Data Source
  KAKENHI-PROJECT-26293014
[Presentation] Novel anti-sepsis strategy targeting the endothelial cell-specific receptor Robo42016
- Author(s)
  Yoshiaki Okada, Keisuke Shirakura, Kiichiro Yano, Naoya Shigesada, Yu Fukushima, Ryosuke Ishiba, Taito Kashio, William C. Aird, Takefumi Doi
- Organizer
  第２回春期特別日本血管生物医学会シンポジウム
- Place of Presentation
  大阪大学（大阪）
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293014
[Presentation] Claudin を標的とした創薬基盤技術の開発～claudin-4 を標的としたがん治療戦略の有効性及び安全性の評価～2016
- Author(s)
  松田基, 橋本洋佑, 川東祐美, 畑智幸, 渡利彰浩, 近藤昌夫, 岡田欣晃，多田稔, 石井明子, 深澤征義, 土井健史, 八木清仁
- Organizer
  日本薬学会　第136年会
- Place of Presentation
  横浜（神奈川県）
- Year and Date
  2016-03-29
- Data Source
  KAKENHI-PROJECT-26293014
[Presentation] 血管内皮細胞特異的受容体を標的とする新規全身性炎症治療薬の開発2015
- Author(s)
  重定直弥、真鍋詩織、山本奈那、William Aird、岡田欣晃、土井健史
- Organizer
  第１４回次世代を担う若手ファーマ・バイオフォーラム2015
- Place of Presentation
  千葉大学亥鼻キャンパス(千葉県)
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-26293014
[Presentation] Robo4プロモーターの血管内皮細胞特異的なDNAメチル化パターン形成に寄与する因子の探索2015
- Author(s)
  田中亨、間庭佑典、岡田淳雅、川端健二、Aird WC、岡田欣晃、土井健史
- Organizer
  第９回日本エピジェネティクス研究会年会
- Place of Presentation
  学術総合センター一橋講堂（東京都）
- Year and Date
  2015-05-25
- Data Source
  KAKENHI-PROJECT-26293014
[Presentation] 脂質異常症治療薬を目指した核内受容体PPARαの新規活性化化合物の開発2015
- Author(s)
  杠智博, 橘敬祐, 前川貴志, 田畑遼太朗, 石本憲司, 小林直之, 田中十志也, 児玉龍彦, 宮地弘幸, 土井健史
- Organizer
  第65回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-15H02896
[Presentation] 血管内皮細胞特異的な遺伝子発現とDNAメチル化2015
- Author(s)
  岡田欣晃、William Aird、土井健史
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学院大学（兵庫）
- Year and Date
  2015-03-26
- Invited
- Data Source
  KAKENHI-PROJECT-26293014
[Presentation] 脂質代謝制御因子Lipin1と分解メカニズムの解明2015
- Author(s)
  奥野紘子, 石本憲司, 熊谷文子, 早瀬絢香, 樋野展正, 橘敬祐, 川村猛, 田中十志也, 児玉龍彦, 土井健史
- Organizer
  第16回 Pharmaco-Hematologyシンポジウム
- Place of Presentation
  東京
- Year and Date
  2015-06-13
- Data Source
  KAKENHI-PROJECT-15H02896
[Presentation] 血管内皮細胞特異的受容体Robo4 の炎症応答における役割2014
- Author(s)
  白倉圭佑、酒井美貴、福島優、真鍋詩織、William Aird、岡田欣晃、土井健史
- Organizer
  第15回Pharmaco-Hematologyシンポジウム
- Place of Presentation
  名古屋市立大学大学院薬学研究科（愛知）
- Year and Date
  2014-05-24
- Data Source
  KAKENHI-PROJECT-26293014
[Presentation] DNA methylation of the proximal promoter regulates endothelial cell-specific Robo4 gene expression2014
- Author(s)
  Yoshiaki Okada, Nobuaki Funahashi, Yuji Nishiyama, Toru Tanaka, Keisuke Shirakura, Yusuke Maniwa, William C. Aird, Takefumi Doi
- Organizer
  The 18th International Vascular Biology Meeting
- Place of Presentation
  みやこめっせ（京都）
- Year and Date
  2014-04-14
- Data Source
  KAKENHI-PROJECT-26293014
[Presentation] 血管内皮細胞特異的受容体Robo4 の血管透過性制御における役割2014
- Author(s)
  山内沙織、白倉圭佑、William C Aird、岡田欣晃、土井健史
- Organizer
  第64回日本薬学会近畿支部総会・大会
- Place of Presentation
  京都薬科大学（京都）
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PROJECT-26293014
[Presentation] Roles of Endothelial cell specific receptor, Robo4 in inflammatory response2014
- Author(s)
  Keisuke Shirakura, Miki Sakai, Yu Fukushima, Shiori Manabe, William C. Aird, Yoshiaki Okada, Takefumi Doi
- Organizer
  第8回SKOシンポジウム
- Place of Presentation
  大阪大学銀杏会館（大阪）
- Year and Date
  2014-06-10
- Data Source
  KAKENHI-PROJECT-26293014
[Presentation] Robo4 発現抑制による炎症抑制機構の解析と敗血症治療薬開発への応用2014
- Author(s)
  真鍋詩織、山本奈那、Aird WC、岡田欣晃、土井健史
- Organizer
  第64回日本薬学会近畿支部総会・大会
- Place of Presentation
  京都薬科大学（京都）
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PROJECT-26293014
[Presentation] Robo4遺伝子の組織特異的な発現を制御するDNA メチル化サイトについての解析2012
- Author(s)
  西山侑児、酒井美貴、鈴木綾乃、加納義浩、舟橋伸昭、岡田欣晃、土井健史
- Organizer
  第13回Pharmaco-Hematologyシンポジウム
- Place of Presentation
  日本薬学会長井記念ホール(東京都)
- Year and Date
  2012-06-16
- Data Source
  KAKENHI-PROJECT-23659040
[Presentation] DNA メチル化サイトへの点変異導入はRobo4プロモーターの組織特異性を失わせる2012
- Author(s)
  岡田欣晃、西山侑児、鈴木綾乃、酒井美貴、舟橋伸昭、加納義浩、William Aird、土井健史
- Place of Presentation
  学術総合センター(東京都)
- Year and Date
  2012-05-14
- Data Source
  KAKENHI-PROJECT-23659040
[Presentation] Robo4プロモーターの組織特異的なDNAメチル化パターンが決定されるメカニズムの解析2012
- Author(s)
  酒井美貴、西山侑児、舟橋伸昭、柿内康司、間庭佑典、岡田欣晃、土井健史
- Organizer
  日本薬学会第133年会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2012-03-28
- Data Source
  KAKENHI-PROJECT-23659040
[Presentation] Robo4 遺伝子の組織特異的な発現はDNA メチル化により制御される-血管内皮細胞特異的な遺伝子発現が生み出されるメカニズムとは-2012
- Author(s)
  岡田欣晃, William Aird, 土井健史
- Organizer
  第62回日本薬学会近畿支部総会・大会
- Place of Presentation
  武庫川女子大学薬学部(兵庫県)(招待講演)
- Year and Date
  2012-10-20
- Data Source
  KAKENHI-PROJECT-23659040
[Presentation] DNA メチル化によるRobo4遺伝子の組織特異的発現の制御 Robo4 遺伝子はなぜ血管内皮細胞特異的に発現するのか-2011
- Author(s)
  岡田欣晃、西山侑児、鈴木綾乃、酒井美貴、舟橋伸昭、加納義浩、成瀬啓樹、William Aird、土井健史
- Organizer
  第61回日本薬学会近畿支部総会・大会
- Place of Presentation
  神戸学院大学ポートアイランドキャンパス(兵庫県)
- Year and Date
  2011-10-22
- Data Source
  KAKENHI-PROJECT-23659040
[Presentation] DNAメチル化はRobo4遺伝子を血管内皮細胞特異的に発現させる2011
- Author(s)
  岡田欣晃、舟橋伸昭、加納義浩、西山侑児、成瀬啓樹、鈴木綾乃、William Aird、土井健史
- Organizer
  第5回日本エピジェネティクス研究会年会
- Place of Presentation
  KKRホテル熊本(熊本県)
- Year and Date
  2011-05-19
- Data Source
  KAKENHI-PROJECT-23659040
[Presentation] 家族性血小板減少症患者にみられる変異型RUNX1の機能解析2010
- Author(s)
  渡邊美穂, 米倉正哲, 仲井友子, 登治謙, 志水美己子, 岡田欣晃, 土井健史
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山桃太郎アリーナ(岡山県)
- Year and Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-19390022
[Presentation] 血管内皮細胞特異的に発現するレセプターROBO4とSLITの相互作用解析2010
- Author(s)
  蒋志侠、鈴木綾乃、舟橋伸昭、加納義浩、成瀬啓樹、岡田欣晃、土井健史
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-20200017
[Presentation] ROBO4の血管内皮細胞特異的発現制御とDNAメチル化の関連性の解析2010
- Author(s)
  加納義浩、舟橋伸昭、成瀬啓樹、蒋志侠、鈴木綾乃、岡田欣晃、土井健史
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-20200017
[Presentation] Robo4プロモーターに存在するGABP結合配列のin vivoにおける重要性2009
- Author(s)
  岡田欣晃、金恩京、北山美絵、舟橋伸昭、矢野喜一郎、Aird WC、土井健史
- Organizer
  第10回Pharmaco-Hematologyシンポジウム
- Place of Presentation
  東京
- Year and Date
  2009-06-20
- Data Source
  KAKENHI-PROJECT-20200017
[Presentation] 血管内皮細胞に特異的に発現するRobo4遺伝子の新規転写調節配列の同定と解析2009
- Author(s)
  成瀬啓樹、蒋志侠、舟橋伸昭、加納義浩、鈴木綾乃、Aird WC、岡田欣晃、土井健史
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-20200017
[Presentation] Ligand independent assembly of purified soluble Magic Roundabout (Robo4), a tumor-specific endothelial marker2009
- Author(s)
  Yoshikawa M, Mukai Y, Okada Y, Yoshioka Y, Tsunoda S, Tsutsumi Y, Okada N, Aird WC, Doi T, Nakagawa S
- Organizer
  ECCO 15 and 34th ESMO Multidisciplinary Congress
- Place of Presentation
  Berlin (Germany)
- Data Source
  KAKENHI-PROJECT-20200017
[Presentation] 51 ETSサイトを介するPF4遺伝子の発現制御メカニズムの解明2009
- Author(s)
  登治謙, 渡邊美穂, 米倉正哲, 志水美己子, 仲井友子, 岡田欣晃, 土井健史
- Organizer
  第8回次世代を担う若手ファーマバイオフォーラム2009
- Place of Presentation
  名古屋市立大学田辺通キャンパス(愛知県)
- Year and Date
  2009-11-14
- Data Source
  KAKENHI-PROJECT-19390022
[Presentation] Robo4遺伝子の血管内皮細胞特異的な発現とDNAメチル化との関連2009
- Author(s)
  舟橋伸昭、成瀬啓樹、加納義浩、Ziang Zhixia、鈴木綾乃、岡田欣晃、土井健史
- Organizer
  第8回次世代を担う若手ファーマバイオフォーラム2009
- Place of Presentation
  名古屋
- Year and Date
  2009-11-14
- Data Source
  KAKENHI-PROJECT-20200017
[Presentation] -51 ETSサイトを介する血小板第4因子遺伝子の発現制御機構の解析2009
- Author(s)
  登治謙, 渡邊美穂, 米倉正哲, 岡田欣晃, 土井健史
- Organizer
  日本薬学会第129年会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2009-03-26
- Data Source
  KAKENHI-PROJECT-19390022
[Presentation] Ligand independent assembly of purified soluble Magic Roundabout (Robo4), a tumor-specific endothelial marker2009
- Author(s)
  Yoshikawa M, Mukai Y, Okada Y, Yoshioka Y, Tsunoda S, Tsutsumi Y, Okada N, Aird WC, Doi T, Nakagawa S
- Organizer
  ECCO 15 and 34th ESMO Multidisciplinary Congress
- Place of Presentation
  Berlin, Germany
- Data Source
  KAKENHI-PROJECT-20200017
[Presentation] 血小板第4因子遺伝子の発現制御における-51 ETSサイトの役割2009
- Author(s)
  登治謙, 渡邊美穂, 米倉正哲, 岡田欣晃, 土井健史
- Organizer
  第10回Pharmaco-Hematologyシンポジウム
- Place of Presentation
  日本薬学会長井記念ホール(東京都)
- Year and Date
  2009-06-19
- Data Source
  KAKENHI-PROJECT-19390022
[Presentation] 新規血管内皮細胞マーカーRobo4のin vivo発現制御機構解析2008
- Author(s)
  岡田欣晃、金恩京、北山美絵、舟橋伸昭、矢野喜一郎、William Aird、土井健史
- Organizer
  第81回日本生化学会大会第31回日本分子生物学会年会合同大会(BMB2008)
- Place of Presentation
  神戸
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-20200017
[Presentation] 血管内皮細胞と非血管内皮細胞におけるROBO4プロモーターのDNAメチル化状態の相違2008
- Author(s)
  舟橋伸昭、成瀬啓樹、加納義浩、Zhixia Jiang、岡田欣晃、土井健史
- Organizer
  第81回日本生化学会大会第31回日本分子生物学会年会合同大会(BMB2008)
- Place of Presentation
  神戸
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-20200017
[Presentation] 家族性血小板減少症(FPD)に見られるRUNX1変異体を血小板系列特異的に発現するES細胞株の樹立2008
- Author(s)
  渡邊美穂, 北山美絵, 原敏郎, 米倉正哲, 登治謙, 山崎大典, William Aird, 北島健二, 仲野徹, 岡田欣晃, 土井健史
- Organizer
  Biochemistry and Molecular Biology 2008
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-19390022
[Presentation] Difference of the methylation pattern of the Robo 4 promoter between endothelial cell and non-endothelial cell2008
- Author(s)
  Yoshiaki Okada, Nobuaki Funahashi, Yoshihiro Kano, Hiroki Naruse, Zhixia Jiang, Enjing Jin, Kiichiro Yano, William Aird, Takefumi Doi
- Organizer
  The 6^<th> Korea Japan Joint Symposium on Vascular Biology and The 16th Annual Meeting of the Japan Vascular Biology and Medicine Organization JOINT MEETING
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-20200017

1. IMANISHI Takeshi (40028866)

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2. KODAMA Tatsuhiko (90170266)

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3. OKADA Yoshiaki (50444500)

# of Collaborated Projects: 4 results

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4. Keisuke Tachibana (30432446)

# of Collaborated Projects: 3 results

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5. MAEDA Nobuyo

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6. GORDON Siamon

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7. NAKANO Toru (00172370)

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8. KITA Tohru (60161460)

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9. MIYASHITA Kazuyuki (10166168)

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10. OBIKA Satoshi (80243252)

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11. WADA Yoichiro (10322033)

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16. FREEMAN Mason W.

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17. TRIGGVASON K

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18. KODAMA Tetsuya (00432443)

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19. MUKAI Yohei (60444501)

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21. MORITA Masahito (30381594)

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23. NAKAGAWA Shinsaku (70207728)

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24. YAMAMOTO Takao (00174798)

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25. INUBUSHI Toshiro (20213142)

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28. KURODA Etsushi (10299604)

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29. NAGANO Yutaka (80228048)

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30. MATSUHASHI Nobuyuki (10221590)

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31. ABURATANI Hiroyuki (10202657)

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32. EMI Mitsuru (90221118)

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33. NIKI Etsuo (20011033)

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34. MATOU Masao (80048941)

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35. SATO Ryuichiro (50187259)

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36. NAITO Makoto (30045786)

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37. NOGUCHI Noriko (40198578)

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38. MINAMI Takashi (00345141)

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39. TAIRA Kazunari (10261778)

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40. 池水信二 (60333522)

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41. 井上豪 (20263204)

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42. 吉田卓也 (00294116)

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43. 山口卓男 (80596601)

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44. NAGANO Hiroyuki

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45. SADAHIRO Ryuhzou

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46. NAKAJIMA Atsushi

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48. 長野洋幸

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49. MINNICH Anne

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50. TRYGGVASON Karl

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51. TAKASHIMA Seiji

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52. 川村猛

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53. 酒井寿郎

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54. 深田宗一朗

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55. 国安弘基

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56. 舟橋伸昭

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DOI Takefumi 土井 健史

土井 健文 ドイ タケフミ

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Analysis of cancer specific signaling cascade by in vivo protein photo-cross-linking approachPrincipal Investigator

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Analysis of molecular mechanism regulating enzyme function of histone methylation enzyme SETDB1Principal Investigator

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Innovative Drug Development for Histone MethylasePrincipal Investigator

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Regulation mechanisms involved in tissue-specific gene expressionPrincipal Investigator

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Transcription factors regulating normal and pathological platelet differentiationPrincipal Investigator

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Analyses of transcription factors related to megakaryocyte differentiation and maturation.Principal Investigator

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DOI Takefumi 土井健史

土井健文ドイタケフミ