TAKEUCHI Kazuhiko 竹内和彦

Researcher Number	00419425
Affiliation (based on the past Project Information) *help	2008 – 2014: Hamamatsu University School of Medicine, 医学部, 准教授 2013: 浜松医科大学, 医学部, 準教授 2007 – 2008: Hamamatsu University School of Medicine, 医学部, 助教
Review Section/Research Field	Principal Investigator Applied pharmacology / General pharmacology Except Principal Investigator Rehabilitation science/Welfare engineering / Gastroenterology / Medical pharmacy
Keywords	Principal Investigator 近赤外線時間分解分光法 / 反応性充血 / 血管内皮機能 / 遊離脂肪酸 / カルシウム / プロスタグランジンI2 / NO / 内皮依存性血管拡張因子 / 血管内皮 / 虚血性脳卒中 / 循環 … More Except Principal Investigator … More 近赤外線 / 脳梗塞 / 近赤外時間分解分光法 / 脳血流 / クロピドグレル / 抗血小板薬 / アスピリン / UGT1A6 / CYP2C9 / Aspirin / SLCO1B1 / 遺伝子多型 / 胃粘膜傷害 / H. pylori / 低用量アスピリン / 臨床試験 / 降圧薬 / 健康食品 / 血漿中濃度 / 薬物相互作用 / カルシウム拮抗薬 / グレープフルーツジュース / 臨床効果 / 相互作用 / 臨床薬学 Less

Development of genomics-based prophylaxis strategy for gastric mucosal injury induced by anti-platelet agents
- Principal Investigator
  
  FURUTA TAKAHISA
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Hamamatsu University School of Medicine
Postural-related Cerebral Hemodynamic Responses Assessed by Near Infrared Spectroscopy in Patients with Chronic Cerebral Infarction
- Principal Investigator
  
  IRISAWA Hiroshi
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Rehabilitation science/Welfare engineering
- Research Institution
  Hamamatsu University School of Medicine
Establishment of novel evaluation methods to measure endothelial functions as a clinical pharmacological toolPrincipal Investigator
- Principal Investigator
  
  TAKEUCHI Kazuhiko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Hamamatsu University School of Medicine
Effect of the intake of grapefruit juice on blood pressures in hypertensive patients treated with calcium channel blockers
- Principal Investigator
  
  UCHIDA Shinya
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  University of Shizuoka
Involvement of free fatty acids and 20-hydroxyeicosatetraenoic acid(20-HETE)in ischemic strokePrincipal Investigator
- Principal Investigator
  
  TAKEUCHI Kazuhiko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Hamamatsu University School of Medicine

All 2012 2011 2010 2009 2008 Other

All Journal Article Presentation

[Journal Article] Effect of 2 weeks' consumption of pomegranate juice on the pharmacokinetics of a single dose of midazolam : an open-label, randomized, single-center, 2-period crossover study in healthy Japanese volunteers2011
- Author(s)
  Shingen Misaka, Reiko Nakamura, Shinya Uchida, Kazuhiko Takeuchi, Norio Takahashi, Naoki Inui, Kazuhiro Kosuge, Shizuo Yamada, Hiroshi Watanabe
- Journal Title
  
  Clin. Ther
  
  Volume: 33 Pages: 246-252
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590171
[Journal Article] Benzbromarone pharmacokinetics and pharmacodynamics in different cytochrome P450 2C9 genotypes2010
- Author(s)
  Shinya Uchida, Kayoko Shimada, Shingen Misaka, Hiromitu Imai, Yasuhiro Katoh, Naoki Inui, Kazuhiko Takeuchi, Takashi Ishizaki, Shizuo Yamada, Kyoichi Ohashi, Noriyuki Namiki, Hiroshi Watanabe
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 25 Pages: 605-610
- NAID
  10027743998
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590171
[Journal Article] Misinterpretation of the effect of amlodipine on cytosolic calcium concentration with fura-2 fluorospectrometry2008
- Author(s)
  Asai M, Takeuchi K, Saotome M, Urushida T, Katoh H, Satoh H, Hayashi H, Watanabe H.
- Journal Title
  
  Naunyn-Schmiede berg's Archives of Pharmacology 377(4-6)
  
  Pages: 423-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590244
[Journal Article] Misinterpretation of the effect of amlodipine on cytosolic calcium concentration with fura-2 fluorospectrometry2008
- Author(s)
  Asai M, Takeuchi K, Watanabe H
- Journal Title
  
  Naunyn-Schmiedeberg's Archives of Pharmacology 377(4-6)
  
  Pages: 423-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590244
[Journal Article] Extracellular acidosis suppresses endothelial function by inhibiting store-operated Ca^<2+> entry via nonselective cation channels
- Author(s)
  Asai M, Takeuchi K, Saotome M, Urushida T, Katoh H, Satoh H, Hayashi H, Watanabe H.
- Journal Title
  
  Cardiovascular Research (in press)
- Data Source
  KAKENHI-PROJECT-19590244
[Presentation] Biomarkers for Endothelial Function2012
- Author(s)
  竹内和彦
- Organizer
  第33 回日本臨床薬理学会学術総会 BPS/JSCPT Joint Symposium
- Place of Presentation
  沖縄県那覇市
- Data Source
  KAKENHI-PROJECT-22590499
[Presentation] Biomarkers for Endothelial Function.2012
- Author(s)
  Takeuchi K, Watanabe H
- Organizer
  第33回日本臨床薬理学会学術総会 BPS/JSCPT Joint Symposium
- Place of Presentation
  那覇
- Year and Date
  2012-11-29
- Data Source
  KAKENHI-PROJECT-22590499
[Presentation] Omega-6 PUFA-induced endothelial dysfunction2011
- Author(s)
  Wei Jiazhag, Kazuhiko Takeuchi
- Organizer
  第75日本循環器学会学術年会
- Place of Presentation
  横浜
- Year and Date
  2011-03-20
- Data Source
  KAKENHI-PROJECT-22590499
[Presentation] 薬物相互作用検出のためのin vivoでのラットおよび健常人対象試験2011
- Author(s)
  内田信也、田中紫茉子、乾直輝、竹内和彦、渡邉裕司、大橋京一、並木徳之
- Organizer
  第32回日本臨床薬理学会年会
- Place of Presentation
  浜松
- Year and Date
  2011-12-02
- Data Source
  KAKENHI-PROJECT-21590171
[Presentation] 血管皮細胞機能に対する遊離脂肪酸の影響2011
- Author(s)
  竹内和彦, Wei Jiazhang, 渡邉裕司
- Organizer
  第4回静岡県血栓と血管フォーラム
- Place of Presentation
  静岡
- Year and Date
  2011-01-02
- Data Source
  KAKENHI-PROJECT-22590499
[Presentation] Inhibitory effects of Omega-6 polyunsaturated fatty acids on endothelial function2011
- Author(s)
  Wei J, Takeuchi K, Inui N, Watanabe H
- Organizer
  The 5th China-Japan Joint Meeting of Basic and Clinical Pharmacology
- Place of Presentation
  Urumqi, China
- Year and Date
  2011-08-08
- Data Source
  KAKENHI-PROJECT-22590499
[Presentation] Omega-6 PUFA- induced endothelial dysfunction2011
- Author(s)
  Wei J, Takeuchi K Watanabe H
- Organizer
  第75 日本循環器学会学術年会
- Place of Presentation
  横浜
- Year and Date
  2011-03-20
- Data Source
  KAKENHI-PROJECT-22590499
[Presentation] ω6-polyunsatulated fatty acids, but not other free fatty acids, evoke endothelial dysfunction by inhibiting store-operated Caentries.2010
- Author(s)
  竹内和彦、Wei Jiazhang、乾直輝、渡邉裕司
- Organizer
  16th World congress on Basic and Clinical Pharmacology
- Place of Presentation
  デンマーク
- Year and Date
  2010-07-22
- Data Source
  KAKENHI-PROJECT-22590499
[Presentation] The functional changes in regenerated endothelial cells.2010
- Author(s)
  竹内和彦、渡邉裕司
- Organizer
  XXth World Congress of the ISHR
- Place of Presentation
  京都
- Year and Date
  2010-05-13
- Data Source
  KAKENHI-PROJECT-22590499
[Presentation] Omega-6 Polyunsaturated Fatty Acids, Arachidonic and Linoleic acids, but not other Free Fatty Acids, Suppress Endothelial Ca2+ Signaling and Functions2009
- Author(s)
  Takeuchi K, Asai M, Watanabe H
- Organizer
  第73回日本循環器学会学術総会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2009-03-20
- Data Source
  KAKENHI-PROJECT-19590244
[Presentation] Omega-6 polyunsaturated fatty acids, arachidonic and linoleic acids, but not other free fatty acids, suppress endothelial Ca^<2+> signaling and functions2009
- Author(s)
  Takeuchi K, Watanabe H.
- Organizer
  第73回日本循環器学会学術総会
- Place of Presentation
  大阪
- Year and Date
  2009-03-20
- Data Source
  KAKENHI-PROJECT-19590244
[Presentation] 酸性環境下における血管内皮機能2009
- Author(s)
  竹内和彦、浅井正嘉、渡邉裕司
- Organizer
  第9回日本NO学会学術集会
- Place of Presentation
  静岡
- Year and Date
  2009-05-09
- Data Source
  KAKENHI-PROJECT-19590244
[Presentation] Free Fatty Acids (FFAs), Arachidonic and Linoleic Acids but not other FFAs,Suppress Endothelial Function by Inhibiting Endothelial Ca2+ Responses2008
- Author(s)
  Takeuchi K, Iida K, Watanabe H
- Organizer
  第72回日本循環器学会学術総会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-19590244
[Presentation] Free fatty acids(FFAs), arachidonic and linoleic acids but not other FFAs, suppress endothelial function by inhibiting endothelial Ca^<2+> responses2008
- Author(s)
  Takeuchi K, Watanabe H.
- Organizer
  第73回日本循環器学会学術総会
- Place of Presentation
  福岡
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-19590244

1. WATANABE Hiroshi (50262803)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. INUI Naoki (80402254)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
3. UCHIDA Shinya (80372522)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. IMAI Hiromitsu (30398250)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. YAMADA Hiroshi (40265252)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. KOSUGE Kazuhiro (00283375)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. TANAKA Shimako (10559925)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. FURUTA TAKAHISA (10303546)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SUGIMOTO Mitsushige (80397398)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. OGAWA Noriyoshi (80308618)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MATSUYAMA Yukihiro (20312316)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. NANBA Hiroki (60198405)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. UMEMURA Kazuo (40232912)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. IRISAWA Hiroshi (70467231)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. MIZUSHIMA Takashi (80279348)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 渡邊裕司

# of Collaborated Projects: 0 results

# of Collaborated Products: 14 results

TAKEUCHI Kazuhiko 竹内 和彦

Research Projects

Research Products

Co-Researchers

Development of genomics-based prophylaxis strategy for gastric mucosal injury induced by anti-platelet agents

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Postural-related Cerebral Hemodynamic Responses Assessed by Near Infrared Spectroscopy in Patients with Chronic Cerebral Infarction

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of novel evaluation methods to measure endothelial functions as a clinical pharmacological toolPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effect of the intake of grapefruit juice on blood pressures in hypertensive patients treated with calcium channel blockers

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Involvement of free fatty acids and 20-hydroxyeicosatetraenoic acid(20-HETE)in ischemic strokePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Effect of 2 weeks' consumption of pomegranate juice on the pharmacokinetics of a single dose of midazolam : an open-label, randomized, single-center, 2-period crossover study in healthy Japanese volunteers2011

Author(s)

Journal Title

Data Source

[Journal Article] Benzbromarone pharmacokinetics and pharmacodynamics in different cytochrome P450 2C9 genotypes2010

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Misinterpretation of the effect of amlodipine on cytosolic calcium concentration with fura-2 fluorospectrometry2008

Author(s)

Journal Title

Data Source

[Journal Article] Misinterpretation of the effect of amlodipine on cytosolic calcium concentration with fura-2 fluorospectrometry2008

Author(s)

Journal Title

Data Source

[Journal Article] Extracellular acidosis suppresses endothelial function by inhibiting store-operated Ca^<2+> entry via nonselective cation channels

Author(s)

Journal Title

Data Source

[Presentation] Biomarkers for Endothelial Function2012

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Biomarkers for Endothelial Function.2012

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Omega-6 PUFA-induced endothelial dysfunction2011

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 薬物相互作用検出のためのin vivoでのラットおよび健常人対象試験2011

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 血管皮細胞機能に対する遊離脂肪酸の影響2011

Author(s)

TAKEUCHI Kazuhiko 竹内和彦