Komine Okiru 小峯起

… Alternative Names

KOMINE Okiru 小峯起

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Researcher Number	00456211
Other IDs	https://orcid.org/0000-0003-0845-7358
Affiliation (Current)	2025: 名古屋大学, 環境医学研究所, 講師
Affiliation (based on the past Project Information) *help	2022 – 2024: 名古屋大学, 環境医学研究所, 講師 2021: 名古屋大学, 環境医学研究所, 助教 2014 – 2018: 名古屋大学, 環境医学研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Neurochemistry/Neuropharmacology Except Principal Investigator Biological Sciences / Neurology
Keywords	Principal Investigator 免疫系 / ミクログリア / アルツハイマー病 / 末梢免疫 / 免疫細胞 / グリア細胞 / 自然免疫 / 筋萎縮性側索硬化症 / 神経炎症 / シングルセル解析 … More / 疾患関連ミクログリア / 神経変性疾患 / 脳神経疾患 / アストロサイト … More Except Principal Investigator 神経変性疾患 / 細胞外環境 / 脊髄 / 脊髄環境 / 環境 / グリア / ALS / アストロサイト Less

アルツハイマー病における免疫系による恒常性及び疾患関連ミクログリア制御機構の解明Principal Investigator
- Principal Investigator
  
  小峯起
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Nagoya University
アルツハイマー病の神経炎症における免疫系応答の役割解明Principal Investigator
- Principal Investigator
  
  小峯起
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Nagoya University
Elucidating mechanisms of the functional shift toward neuro-toxic astrocyte in amyotrophic lateral sclerosisPrincipal Investigator
- Principal Investigator
  
  Komine Okiru
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Nagoya University
Elucidating pathomechanism of ALS through the abnormality in astrocytes
- Principal Investigator
  
  YAMANAKA Koji
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Nagoya University
The mechanism for regulating activated glial cells by immune cells in amyotrophic lateral screlosis mice.Principal Investigator
- Principal Investigator
  
  KOMINE Okiru
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Nagoya University
Spinal cord environment: elucidating the mechanism of neurodegeneration through glia-neuron interaction
- Principal Investigator
  
  Yamanaka Koji
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
  The Institute of Physical and Chemical Research

All 2023 2021 2019 2018 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation Book

[Book] 脳内環境事典2017
- Author(s)
  小峯起、山中宏二
- Total Pages
  2
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-26830046
[Book] Neuroinflammation in motor neuron disease2016
- Author(s)
  Endo F, Komine O, Yamanaka K
- Total Pages
  13
- Publisher
  Clinical and Experimental Neuroimmunology
- Data Source
  KAKENHI-PROJECT-26830046
[Book] Modern Physician2016
- Author(s)
  小峯起、山中宏二
- Total Pages
  5
- Publisher
  新興医学出版社
- Data Source
  KAKENHI-PROJECT-26830046
[Book] Clinical Neuroscience Vol.33 12月号　ミクログリア2015
- Author(s)
  小峯　起、山中宏二
- Total Pages
  4
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-26830046
[Book] 遺伝子医学MOOK26 脳内環境ー維持機構と破綻がもたらす疾患研究2014
- Author(s)
  小峯起、山中宏二
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-26293208
[Book] 遺伝子医学MOOK 26号　脳内環境－維持機構と破綻がもたらす疾患研究2014
- Author(s)
  小峯起、山中宏二
- Total Pages
  6
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-26830046
[Book] すべてがわかるALS・運動ニューロン疾患2013
- Author(s)
  山中宏二、小峯起
- Publisher
  中山書店
- Data Source
  KAKENHI-PLANNED-23111006
[Journal Article] Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes2018
- Author(s)
  Komine Okiru、Yamashita Hirofumi、Fujimori-Tonou Noriko、Koike Masato、Jin Shijie、Moriwaki Yasuhiro、Endo Fumito、Watanabe Seiji、Uematsu Satoshi、Akira Shizuo、Uchiyama Yasuo、Takahashi Ryosuke、Misawa Hidemi、Yamanaka Koji
- Journal Title
  
  Cell Death & Differentiation
  
  Volume: 印刷中 Issue: 12 Pages: 2130-2146
- DOI
  10.1038/s41418-018-0098-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08522, KAKENHI-PROJECT-26293208, KAKENHI-PUBLICLY-16H01336, KAKENHI-PUBLICLY-17H05698, KAKENHI-PROJECT-17H04257, KAKENHI-PROJECT-18H02571, KAKENHI-PROJECT-18H02740, KAKENHI-PROJECT-17H04986, KAKENHI-PROJECT-17K19543, KAKENHI-PROJECT-17K14963
[Journal Article] Intracerebroventricular administration of Cystatin C ameliorates disease in SOD1-linked amyotrophic lateral sclerosis mice2018
- Author(s)
  Watanabe Seiji、Komine Okiru、Endo Fumito、Wakasugi Keisuke、Yamanaka Koji
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: 145 Issue: 1 Pages: 80-89
- DOI
  10.1111/jnc.14285
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K14963, KAKENHI-PROJECT-17H04986, KAKENHI-PROJECT-16K09671, KAKENHI-PROJECT-17K07329
[Journal Article] The multi-dimensional roles of astrocytes in ALS2018
- Author(s)
  Yamanaka Koji、Komine Okiru
- Journal Title
  
  Neuroscience Research
  
  Volume: 126 Pages: 31-38
- DOI
  10.1016/j.neures.2017.09.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K14963, KAKENHI-PROJECT-26293208, KAKENHI-PUBLICLY-16H01336
[Journal Article] Neuroinflammation in motor neuron disease.2016
- Author(s)
  Endo F, Komine O, Yamanaka K.
- Journal Title
  
  Clinical and Experimental Neuroimmunology
  
  Volume: 7 Issue: 2 Pages: 126-138
- DOI
  10.1111/cen3.12309
- NAID
  120005672307
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-16H01336, KAKENHI-PROJECT-26293208, KAKENHI-PROJECT-16K09671
[Journal Article] Neuregulin 1 confers neuroprotection in SOD1-linked amyotrophic lateral sclerosis mice via restoration of C-boutons of spinal motor neurons.2016
- Author(s)
  Lasiene J, Komine O, Fujimori-Tonou N, Powers B, Endo F, Watanabe S, Shijie J, Ravits J, Horner P, Misawa H, Yamanaka K
- Journal Title
  
  Acta Neuropathologica Communications
  
  Volume: 4 Issue: 1 Pages: 15-15
- DOI
  10.1186/s40478-016-0286-7
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25860252, KAKENHI-PROJECT-26830046, KAKENHI-PLANNED-23111006, KAKENHI-PROJECT-25293020, KAKENHI-PROJECT-26293208
[Journal Article] Mitochondria-associated membrane collapse is a common pathomechanism in SIGMAR1- and SOD1-linked ALS.2016
- Author(s)
  Watanabe S, Ilieva H, Tamada H, Nomura H, Komine O, Endo F, Jin S, Mancias P, Kiyama H, *Yamanaka K.
- Journal Title
  
  EMBO Molecular Medicine
  
  Volume: 8 Issue: 12 Pages: 1421-1437
- DOI
  10.15252/emmm.201606403
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01336, KAKENHI-PROJECT-16H05117, KAKENHI-PROJECT-26293208, KAKENHI-PROJECT-15K19321, KAKENHI-PROJECT-25860252, KAKENHI-PROJECT-26830046, KAKENHI-PROJECT-16K09671
[Journal Article] Neuroinflammation in motor neuron disease.2015
- Author(s)
  Komine O, Yamanaka K
- Journal Title
  
  Nagoya Journal of Medical Science
  
  Volume: 77 Pages: 537-549
- NAID
  120005672307
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23111006
[Journal Article] Neuroinflammation in motor neuron disease2015
- Author(s)
  KOMINE Okiru, YAMANAKA Koji
- Journal Title
  
  Nagoya Journal of Medical Science
  
  Volume: 77 Pages: 537-549
- NAID
  120005672307
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26830046
[Journal Article] Astrocyte-Derived TGF-β1 Accelerates Disease Progression in ALS Mice by Interfering with the Neuroprotective Functions of Microglia and T Cells.2015
- Author(s)
  Endo F, Komine O, Fujimori-Tonou N, Katsuno M, Jin S, Watanabe S, Sobue G, Dezawa M, Wyss-Coray T, Yamanaka K
- Journal Title
  
  Cell Reports
  
  Volume: 11 Issue: 4 Pages: 592-604
- DOI
  10.1016/j.celrep.2015.03.053
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25860252, KAKENHI-PROJECT-26830046, KAKENHI-ORGANIZER-23111001, KAKENHI-PROJECT-26670439, KAKENHI-PROJECT-26293206, KAKENHI-PROJECT-26293208, KAKENHI-PLANNED-26117002, KAKENHI-ORGANIZER-26117001
[Journal Article] Astrocyte-Derived TGF-β1 Accelerates Disease Progression in ALS Mice by Interfering with the Neuroprotective Functions of Microglia and T Cells.2015
- Author(s)
  Endo F, Komine O, et al.
- Journal Title
  
  Cell Reports
  
  Volume: 11 Pages: 592-604
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23111006
[Journal Article] SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system.2014
- Author(s)
  Watanabe S, Ageta-Ishihara N, Nagatsu S, Takao K, Komine O, Endo F, Miyakawa T, Misawa H, Takahashi R, Kinoshita M, Yamanaka K.
- Journal Title
  
  Mol Brain
  
  Volume: 7 Issue: 1 Pages: 62-62
- DOI
  10.1186/s13041-014-0062-1
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-221S0003, KAKENHI-PLANNED-23111006, KAKENHI-PUBLICLY-25116514, KAKENHI-PUBLICLY-25116526, KAKENHI-PROJECT-25293020, KAKENHI-PROJECT-25350989, KAKENHI-PROJECT-25860252, KAKENHI-PUBLICLY-26115529, KAKENHI-PROJECT-26293208, KAKENHI-PROJECT-26440095, KAKENHI-PLANNED-23111002, KAKENHI-PROJECT-25242078
[Presentation] アルツハイマー病モデルマウスにおける末梢免疫環境がミクログリアに与える影響の解明2023
- Author(s)
  小峯起、祖父江　顕、齊藤貴志、山中宏二
- Organizer
  第46回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-21K07273
[Presentation] アルツハイマー病モデルマウスにおけるミクログリア不均一性の変容とその役割の解明2023
- Author(s)
  小峯　起、祖父江　顕、原　雄一郎、紅　朋浩、嶋田繭子、日野原邦彦、荻　朋男、斉藤貴志、西道隆臣、山中宏二
- Organizer
  第42回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07273
[Presentation] アルツハイマー病モデルマウスにおける末梢免疫システムの役割2021
- Author(s)
  小峯起、祖父江顕、斉藤貴志、山中宏二
- Organizer
  第44回　日本神経科学大会
- Data Source
  KAKENHI-PROJECT-21K07273
[Presentation] Behavioral characterization of APP knock-in mice model in touchscreen-based tests aiming early detection of Alzheimer's disease.2019
- Author(s)
  Saifullah MD. Ali Bin、小峯　起、祖父江　顕、山中宏二、溝口博之．
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-17K14963
[Presentation] Innate immune adaptor TRIF confers neuroprotection in ALS mice by eliminating abnormal astrocytes.2018
- Author(s)
  Komine O, Yamashita H, Fujimori-Tonou N, Koike M, Jin S, Moriwaki Y, Endo F, Watanabe S, Uematsu S, Akira S, Uchiyama Y, Takahashi R, Misawa H, Yamanaka K.
- Organizer
  Society for Neuroscience 2018 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K14963
[Presentation] Intracerebroventricular administration of cystatin C extended the survival time of SOD1G93A mouse model.2018
- Author(s)
  Watanabe S, Komine O, Endo F, Wakasugi K, Yamanaka K.
- Organizer
  The29th International Symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K14963
[Presentation] TDP-43C末端ドメイン欠損変異体はNotch1-Akt1シグナル経路を介して加齢依存的な運動障害を引き起こす.2018
- Author(s)
  渡邊征爾、西野晃平、松岡由理、金　世杰、小峯　起、遠藤史人、築地仁美、﨑村健司、山中宏二.
- Organizer
  第41回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-17K14963
[Presentation] 高脂肪食の継続投与はグリア細胞の極性変化を伴い視床下部炎症が増悪する.2018
- Author(s)
  杉山摩利子、坂野僚一、柳沼裕史、滝　啓吾、溝口暁、恒川　卓、高木博史、伊藤禎浩、小峯　起、山中宏二、有馬　寛.
- Organizer
  第39回日本肥満学会
- Data Source
  KAKENHI-PROJECT-17K14963
[Presentation] Mice deficient of C-terminal domain of TDP-43 develop age-dependent motor dysfunction via Notch1-Akt signaling pathway.2018
- Author(s)
  Watanabe S, Nishino K, Matsuoka Y, Jin S, Komine O, Endo F, Tsuiji H, Sakimura K, Mishra A, Yamanaka K.
- Organizer
  5th RNA Metabolism in Neurological Disease Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K14963
[Presentation] 早期アルツハイマー病理を呈する患者脳における神経炎症関連遺伝子発現解析.2018
- Author(s)
  祖父江顕、遠藤史人、小峯　起、村山繁雄、山中宏二.
- Organizer
  第37回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-17K14963
[Presentation] ALSモデルマウスにおける末梢免疫環境がミクログリア機能に与える影響の解明.2018
- Author(s)
  小峯　起、大沼周平、池田早織、山中宏二.
- Organizer
  第41回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-17K14963
[Presentation] グリオシドGD3によるグリオーマの腫瘍微小環境の制御機構2017
- Author(s)
  張　璞，大川裕樹，加藤　彰，小峯　起，百田洋之，Robiul Bhuiyan，大海雄介，古川圭子，若林俊彦，岡島徹也，山中宏二，古川鋼一
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K14963
[Presentation] 筋萎縮性側索硬化症におけるシスタチンCの神経保護効果2017
- Author(s)
  渡邊征爾，小峯　起，遠藤史人，山中宏二
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K14963
[Presentation] Analysis of roles of glial cell subtypes in hypothalamic inflammation induced by a high fat diet.2017
- Author(s)
  Sugiyama M, Banno R, Taki T, Mizoguchi A, Tsunekawa T, Takagi H, Ito Y, Komine O, Yamanaka K, Arima H.
- Organizer
  北米肥満学会(Obesityweek 2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K14963
[Presentation] Innate immune adaptor TRIF slows disease progression of ALS mice by eliminating aberrantly activated astrocytes.2017
- Author(s)
  Komine O, Yamashita H. Fujimori-Tonou N, Uematsu S, Akira S, Yamanaka K.
- Organizer
  28th International symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K14963
[Presentation] 小胞体・ミトコンドリア膜間領域は、筋萎縮性側索硬化症（ALS）の新規治療標的である2017
- Author(s)
  渡邊征爾，小峯　起，遠藤史人，山中宏二
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-17K14963
[Presentation] Magnetic-activated cell sorting法を用いた視床下部アストロサイトの単離と機能解析2017
- Author(s)
  杉山摩利子，坂野僚一，滝　啓吾，溝口　暁，恒川　卓，高木博史，伊藤禎浩，小峯　起，山中宏二，有馬　寛
- Organizer
  第38回日本肥満学会
- Data Source
  KAKENHI-PROJECT-17K14963
[Presentation] Innate immune adaptor TRIF slows disease progression of ALS mice by eliminating aberrantly activated astrocytes.2017
- Author(s)
  Komine O, Yamashita H. Fujimori-Tonou N, Uematsu S, Akira S, Yamanaka K.
- Organizer
  28th International symposium on ALS/MND
- Data Source
  KAKENHI-PROJECT-26293208
[Presentation] ALSモデルマウスのミクログリア機能における末梢免疫の役割2017
- Author(s)
  小峯　起，大沼周平，池田早織，山中宏二
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-17K14963
[Presentation] ALS病態における末梢免疫の役割2016
- Author(s)
  大沼周平、小峯起、山中宏二
- Organizer
  第38回日本生物学的精神医学会・第59回日本神経化学会大会合同年会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-26830046
[Presentation] ユビキチン・プロテアソームシステム機能障害による運動ニューロン神経変性機序2016
- Author(s)
  星野友則、山下博史、田代善祟、三澤日出巳、小峯起、山中宏二、漆谷真、高橋良輔
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-26830046
[Presentation] ALSモデルマウスにおける末梢免疫の役割2016
- Author(s)
  小峯起、大沼周平、池田早織、山中宏二
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-26830046
[Presentation] Neuregulin 1 confers neuroprotection in SOD1-linked ALS mice via restoration of C-boutons of spinal motor neurons.2016
- Author(s)
  Komine O, Lasiene J, Fujimori-Tonou N, Powers B, Endo F, Watanabe S, Jin S, Ravits J, Horner P, Misawa H, Yamanaka K.
- Organizer
  The 27th International Symposium on ALS/MND
- Place of Presentation
  ダブリン
- Year and Date
  2016-12-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293208
[Presentation] Neuregulin 1 confers neuroprotection in SOD1-linked ALS mice via restoration of C-boutons of spinal motor neurons.2016
- Author(s)
  Komine O, Lasiene J, Fujimori-Tonou N, Powers B, Endo F, Watanabe S, Jin S, Ravits J, Horner P, Misawa H, Yamanaka K
- Organizer
  The 27th International Symposium on ALS/MND
- Place of Presentation
  Dublin
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26830046
[Presentation] ALSマウスの疾患進行におけるアストロサイト由来TGF-β1の役割2015
- Author(s)
  遠藤史人、小峯　起、金世杰、勝野雅央、祖父江　元、山中宏二
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-26830046
[Presentation] 動ニューロン特異的26Sプロテアソームノックアウトマウスを用いた運動ニューロンの網羅的遺伝子発現解析2015
- Author(s)
  星野友則、山下博史、田代善祟、三澤日出巳、小峯　起、山中宏二、高橋良輔
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-26830046
[Presentation] Astrocyte-derived TGF-β1 accelerates disease progression in ALS mice by regulating the neuroprotective inflammatory response of microglia and T cells2015
- Author(s)
  山中宏二、遠藤史人、小峯　起、金　世杰、渡邊征爾
- Organizer
  第58回日本神経化学会大会
- Place of Presentation
  大宮ソニックシティ
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PROJECT-26830046
[Presentation] Astrocyte-derived TGF-β1 accelerates disease progression in ALS mice2015
- Author(s)
  遠藤史人、小峯　起、金世杰、山中宏二
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  朱鷺メッセ（新潟）
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-26830046
[Presentation] ALSモデルマウスにおける自然免疫TRIF経路の役割2015
- Author(s)
  小峯　起、山下博史、藤森典子、森脇康博、三澤日出巳、山中宏二
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-26830046
[Presentation] アストロサイト由来TGF-β1はALSの疾患進行を規定する2015
- Author(s)
  遠藤史人、小峯　起、金　世杰、渡邊征爾、山中宏二
- Organizer
  第27回日本神経免疫学会学術集会
- Place of Presentation
  長良川国際会議場（岐阜）
- Year and Date
  2015-09-15
- Data Source
  KAKENHI-PROJECT-26830046
[Presentation] Astrocyte-derived TGF-β1 accelerates disease progression in ALS mice by interfering with neuroprotective functions of microglia and T cells2015
- Author(s)
  ENDO Fumito, KOMINE Okiru, JIN Shijie, WATANABE Seiji, KATSUNO Masahisa, SOBUE Gen, WYSS-CORAY Tony, YAMANAKA Koji
- Organizer
  26th International Symposium on ALS/MLD
- Place of Presentation
  Orlando, USA
- Year and Date
  2015-12-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26830046
[Presentation] ALSモデルマウスにおける自然免疫TRIF経路の役割2015
- Author(s)
  小峯　起、山下博史、藤森典子、森脇康博、三澤日出巳、山中宏二
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PLANNED-23111006
[Presentation] Elimination of innate immune system adaptor TRIF significantly accelerates disease progression of ALS mice.2012
- Author(s)
  Okiru Komine et al.
- Organizer
  Society for Neuroscience 2012
- Place of Presentation
  New Orleans, USA
- Year and Date
  2012-10-12
- Data Source
  KAKENHI-PLANNED-23111006
[Presentation] The role of the infiltrating immune cells attracted by activated microglia in amyotrophic lateral sclerosis mice
- Author(s)
  Okiru Komine, Hirofumi Yamashita, Noriko Fujimori-Tonou, Yasuhiro Moriwaki, Fumito Endo, Seiji Watanabe, Hidemi Misawa and Koji Yamanaka
- Organizer
  Neuroscience 2014 Annual Meeting
- Place of Presentation
  Washington DC, USA
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-26830046
[Presentation] Deletion of TLR-associated signaling adaptor TRIF significantly accelerates disease progression of ALS mice.
- Author(s)
  Okiru Komine et al.
- Organizer
  11th European Meeting on Glial Cells in Health and Disease
- Place of Presentation
  Berlin（ドイツ）
- Year and Date
  2013-07-03 – 2013-07-06
- Invited
- Data Source
  KAKENHI-PLANNED-23111006
[Presentation] 筋萎縮性側索硬化症における浸潤免疫細胞の機能解明
- Author(s)
  小峯起、山下博史、藤森典子、森脇康博、三澤日出巳、山中宏二
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-26830046
[Presentation] The role of the infiltrating immune cells attracted by activated microglia in amyotrophic lateral sclerosis mice
- Author(s)
  Okiru Komine, Hirofumi Yamashita, Noriko Fujimori-Tonou, Yasuhiro Moriwaki, Fumito Endo, Seiji Watanabe, Hidemi Misawa and Koji Yamanaka
- Organizer
  9th Brain Research Conference
- Place of Presentation
  Washington DC, USA
- Year and Date
  2014-11-13 – 2014-11-14
- Data Source
  KAKENHI-PROJECT-26830046

1. YAMANAKA Koji (80446533)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
2. MISAWA Hidemi (80219617)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. Yamashita Hirofumi (60402913)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. WATANABE Seiji (70633577)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
5. ENDO Fumito (10713307)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. Suzumura Akio (50196896)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Takeuchi Hideyuki (30362213)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Takahashi Ryosuke (90216771)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. MORIWAKI Yasuhiro (00392150)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 高橋英機 (40446521)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 内匠透 (00222092)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. TAKAO Keizo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 小池正人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 宮川剛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 阿部修

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 高尾昌樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 渡辺雅彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 石原健

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 高尾英正

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 伊佐正

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 饗場篤

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 高橋淑子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 木下専

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Komine Okiru 小峯 起

KOMINE Okiru 小峯 起

Research Projects

Research Products

Co-Researchers

アルツハイマー病における免疫系による恒常性及び疾患関連ミクログリア制御機構の解明Principal Investigator

Principal Investigator

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アルツハイマー病の神経炎症における免疫系応答の役割解明Principal Investigator

Principal Investigator

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Elucidating mechanisms of the functional shift toward neuro-toxic astrocyte in amyotrophic lateral sclerosisPrincipal Investigator

Principal Investigator

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Research Institution

Elucidating pathomechanism of ALS through the abnormality in astrocytes

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The mechanism for regulating activated glial cells by immune cells in amyotrophic lateral screlosis mice.Principal Investigator

Principal Investigator

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Spinal cord environment: elucidating the mechanism of neurodegeneration through glia-neuron interaction

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[Book] 脳内環境事典2017

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[Book] Neuroinflammation in motor neuron disease2016

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[Book] Modern Physician2016

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[Book] Clinical Neuroscience Vol.33 12月号 ミクログリア2015

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[Book] 遺伝子医学MOOK26 脳内環境ー維持機構と破綻がもたらす疾患研究2014

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[Book] 遺伝子医学MOOK 26号 脳内環境－維持機構と破綻がもたらす疾患研究2014

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[Book] すべてがわかるALS・運動ニューロン疾患2013

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[Journal Article] Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intracerebroventricular administration of Cystatin C ameliorates disease in SOD1-linked amyotrophic lateral sclerosis mice2018

Komine Okiru 小峯起

KOMINE Okiru 小峯起

[Book] Clinical Neuroscience Vol.33 12月号　ミクログリア2015

[Book] 遺伝子医学MOOK 26号　脳内環境－維持機構と破綻がもたらす疾患研究2014