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Yamaguchi Junpei  山口 淳平

ORCIDConnect your ORCID iD *help
Researcher Number 00566987
Affiliation (Current) 2022: 名古屋大学, 医学部附属病院, 病院准教授
Affiliation (based on the past Project Information) *help 2020 – 2022: 名古屋大学, 医学部附属病院, 病院講師
2014 – 2020: 名古屋大学, 医学部附属病院, 助教
Review Section/Research Field
Principal Investigator
Digestive surgery / Basic Section 55020:Digestive surgery-related
Except Principal Investigator
Basic Section 55020:Digestive surgery-related / Digestive surgery / General surgery
Keywords
Principal Investigator
膵癌 / TFF2 / 癌抑制遺伝子 / 膵癌抑制遺伝子 / TFF1 / 前癌病変 / TFF / 癌 / 早期転移 / dormancy … More
Except Principal Investigator
… More ノンコーディングRNA / 胆管癌 / 融合遺伝子 / 術後肝障害 / TFF / 胆道癌 / 全ゲノム解析 / RAGE / 術後感染症 / 癌幹細胞 / TLR7 / Danger signal / 大腸癌 / システイン / 肝障害 / 肝星細胞 / エンドセリン / 敗血症性ショックモデル / 肝虚血再灌流障害 / 必須アミノ酸 / Pre-metastatic niche / TPX2 / 血管新生関連分子 / ビサボロール / 誘導体 / 核酸医薬 / 深紫外線LED / 細胞障害作用 / 癌治療 / 脂肪幹細胞 / 周術期対策 / 血中循環腫瘍細胞 / 生着関連遺伝子 / 非対称分裂 / 自己組織化 / invisible膵癌 / エクソソーム / バイオマーカー / Barrett上皮 / TFF1 / 食道癌 / Barrett食道 / barrett食道 / 食道 / 肝細胞癌 / 原発性肝癌 / TLR4 / 予防治療法 / 化学療法抵抗性 / 腹腔鏡下肝切除 / Navigation Surgery / ナビゲーション手術 / リアルタイムナビゲーションシステム / 高度侵襲消化器外科手術 / 腸内細菌叢プロファイル / 便中有機酸濃度 / バクテリアルトランスロケーション / 術後感染性合併症 / プロバイオティクス / 短鎖脂肪酸 Less
  • Research Projects

    (21 results)
  • Research Products

    (15 results)
  • Co-Researchers

    (16 People)
  •  胆道癌における融合型ノンコーディングRNAの機能解明と臨床応用

    • Principal Investigator
      國料 俊男
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Nagoya University
  •  Whole genome sequencing concerning the chemoresistance of bile duct cancer

    • Principal Investigator
      水野 隆史
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Nagoya University
  •  消化器外科手術後感染性合併症を予防するプロバイオティクス製剤の開発

    • Principal Investigator
      横山 幸浩
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Nagoya University
  •  The mechanisms of early dissemination and tumor dormancy of pancreatic cancerPrincipal Investigator

    • Principal Investigator
      山口 淳平
    • Project Period (FY)
      2020 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Nagoya University
  •  Novel treatment using adipose stem cell for postoperative liver damage

    • Principal Investigator
      ONOE Shunsuke
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Nagoya University
  •  Novel therapy based on engraftment, asymmetric division and Self-organization of circulating tumor cells

    • Principal Investigator
      相場 利貞
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Nagoya University
  •  Novel diagnostic methods for invisible pancreas cancer

    • Principal Investigator
      WATANABE Nobuyuki
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Nagoya University
  •  The role of Trefoil Factors in hepato-carcinogenesis

    • Principal Investigator
      Ebata Tomoki
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Nagoya University
  •  Novel nucleic acid medicine for the fusion genes in cholangiocarcinoma

    • Principal Investigator
      Nagino Masato
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Aichi Cancer Center Research Institute
      Nagoya University
  •  Novel therapy for cancer using deep ultraviolet

    • Principal Investigator
      Miyata Kazushi
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Nagoya University
  •  The mechanisms of cancer development from Barrett esophagus regarding Trefoil Factors.

    • Principal Investigator
      Fukaya Masahide
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Nagoya University
  •  Development of real-time navigation system for hepatectomy

    • Principal Investigator
      IGAMI TSUYOSHI
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Nagoya University
  •  The role of TFF1 to inhibit the development of pancreatic cancerPrincipal Investigator

    • Principal Investigator
      Yamaguchi Junpei
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Nagoya University
  •  術後肝障害に対するTLR4を標的にした予防治療法の開発

    • Principal Investigator
      菅原 元
    • Project Period (FY)
      2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Nagoya University
  •  Novel strategies for cancer stem cells

    • Principal Investigator
      TSUNODA NOBUYUKI
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Nagoya University
  •  Mechanism of a new cancer treatment targeting TLR7

    • Principal Investigator
      UEHARA KEISUKE
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Nagoya University
  •  Analysis of the inhibitory effect of cysteine on liver damage

    • Principal Investigator
      YOKOYAMA YUKIHIRO
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Nagoya University
  •  Novel strategies to target the premetastatic niche for cancer metastasis

    • Principal Investigator
      MIZUNO TAKASHI
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Nagoya University
  •  Mechanism of action of a bisabolol derivative and its clinical application

    • Principal Investigator
      KOKURYO TOSHIO
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Nagoya University
  •  Novel strategies targeting RAGE for postoperative infectious complications

    • Principal Investigator
      FUKAYA MASAHIDE
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Nagoya University
  •  The role of TFF2 as tumor suppressor for pancreatic cancerPrincipal Investigator

    • Principal Investigator
      Yamaguchi Junpei
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Digestive surgery
    • Research Institution
      Nagoya University

All 2021 2020 2019 2018 2017 2015 Other

All Journal Article Presentation Patent

  • [Journal Article] Trefoil factor family 2 inhibits cholangiocarcinogenesis by regulating the PTEN pathway in mice2021

    • Author(s)
      Keiji Hasebe, Junpei Yamaguchi, Toshio Kokuryo, Yukihiro Yokoyama, Yosuke Ochiai, Masato Nagino and Tomoki Ebata
    • Journal Title

      Carcinogenesis

      Volume: 42 (12) Pages: 1496-1505

    • DOI

      10.1093/carcin/bgab093

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K09141
  • [Journal Article] Premalignant pancreatic cells seed stealth metastasis in distant organs in mice2021

    • Author(s)
      Junpei Yamaguchi, Toshio Kokuryo, Yukihiro Yokoyama, Tomoki Ebata, Yosuke Ochiai, Masato Nagino
    • Journal Title

      Oncogene

      Volume: 40 Pages: 2273-2284

    • DOI

      10.1038/s41388-021-01706-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H03751
  • [Journal Article] Trefoil Factor Family 1 Inhibits the Development of Hepatocellular Carcinoma by Regulating β-Catenin Activation2020

    • Author(s)
      Ochiai Y, Yamaguchi J, Kokuryo T, Yokoyama Y, Ebata T, Nagino M
    • Journal Title

      Hepatology

      Volume: - Pages: 503-517

    • DOI

      10.1002/hep.31039

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K09141
  • [Journal Article] Trefoil Factor 1 inhibits epithelial-mesenchymal transition of pancreatic intraepithelial neoplasm.2018

    • Author(s)
      Yamaguchi J, Yokoyama Y, Kokuryo T, Ebata T, Enomoto A, Nagino M.
    • Journal Title

      Journal of Clinical Investigation

      Volume: 128(8) Pages: 3619-3629

    • DOI

      10.1172/jci97755

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10695
  • [Journal Article] Trefoil factor family 1 expression in the invasion front is a poor prognostic factor associated with lymph node metastasis in pancreatic cancer2017

    • Author(s)
      Masaki Sunagawa, Junpei Yamaguchi, Toshio Kokuryo, Tomoki Ebata, Yukihiro Yokoyama, Gen Sugawara, Masato Nagino
    • Journal Title

      Pancreatology

      Volume: 17 (5) Pages: 782-787

    • DOI

      10.1016/j.pan.2017.07.188

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K10695
  • [Patent] TFF1による消化器癌の化学療法感受性増強法2020

    • Inventor(s)
      山口淳平
    • Industrial Property Rights Holder
      名古屋大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Data Source
      KAKENHI-PROJECT-20H03751
  • [Presentation] Trefoil Factor Family 1 (TFF1) Inhibits Epithelial-mesenchymal Transition and Enhances the Chemosensitivity of Pancreatic Ductal Adenocarcinoma (PDAC)2019

    • Author(s)
      J Yamaguchi, T Kokuryo, Y Yokoyama, T Ebata, and M Nagino
    • Organizer
      APA annual meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K10695
  • [Presentation] Trefoil Factor Family 1 Inhibits the Development of Hepatocellular Carcinoma by Regulating β-Catenin Activation.2019

    • Author(s)
      Ochiai Y, Yamaguchi J, Kokuryo T, Yokoyama Y, Ebata T, Nagino M
    • Organizer
      The Liver Meeting 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K09141
  • [Presentation] Trefoil Factor 1 inhibits epithelial-mesenchymal transition (EMT) of pancreatic intraepithelial neoplasm.2018

    • Author(s)
      Junpei Yamaguchi, Yukihiro Yokoyama, Toshio Kokuryo and Masato Nagino
    • Organizer
      AACR Pancreatic cancer: advances in science and clinical care
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K10695
  • [Presentation] 2-Hydroxypropyl-beta-cyclodextrin encapsulated α-bisabolol (CD-BSB) improves the antitumor effect of α-bisabolol for pancreatic cancer2018

    • Author(s)
      Taisuke Baba, Toshio Kokuryo , Yukihiro Yokoyama, Junpei Yamaguchi, Masato Nagino
    • Organizer
      the AACR’s fifth Pancreatic Cancer Special Conference: Advances in Science and Clinical Care
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K10591
  • [Presentation] Preserved expression of TFF1 in invasive front is a poor prognostic factor in PDAC2017

    • Author(s)
      Junpei Yamaguchi, Masaki Sunagawa, Yukihiro yokoyama, Toshio Kokuryo, Tomoki Ebata, Masato Nagino
    • Organizer
      Joint Congress of The 6th Biennial Congress of the Asian-Pacific Hepato-Pancreato-Biliary Association & The 29th Meeting of Japanese Society of Hepato-Biliary-Pancreatic Surgery
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K10695
  • [Presentation] 遺伝子改変マウスを用いたTFF1欠損による膵浸潤癌発生に関する検討2017

    • Author(s)
      山口淳平、江畑智希、横山幸浩、國料俊男、梛野正人
    • Organizer
      第48回日本膵臓学会大会
    • Data Source
      KAKENHI-PROJECT-17K10695
  • [Presentation] 膵癌に対するTrefoil Factor Family 2 (TFF2)の抗腫瘍効果の検討2015

    • Author(s)
      山口淳平、S.P. Thayer, A.L. Warshaw、江畑智希、横山幸弘、國料俊男、伊神剛、菅原元、水野隆司、梛野正人
    • Organizer
      第70回日本消化器外科学会総会
    • Place of Presentation
      静岡県浜松市 アクトシティ浜松
    • Year and Date
      2015-07-15
    • Data Source
      KAKENHI-PROJECT-26893109
  • [Presentation] Trefoil Family Factor 2 (TFF2)抑制による膵IPMN発生マウスモデルの検討2015

    • Author(s)
      山口淳平、S.P. Thayer, A.L. Warshaw、江畑智希、横山幸弘、國料俊男、梛野正人
    • Organizer
      第115回日本外科学会定期学術集会
    • Place of Presentation
      愛知県名古屋市 名古屋国際会議場
    • Year and Date
      2015-04-16
    • Data Source
      KAKENHI-PROJECT-26893109
  • [Presentation] TFF2 (Trefoil Factor Family 2)の膵癌抑制効果の検討

    • Author(s)
      山口淳平、S. P. Thayer、A. L. Warshaw、江畑智希、横山幸浩、國料俊男、梛野正人
    • Organizer
      個体レベルでのがん研究支援活動ワークショップ
    • Place of Presentation
      琵琶湖ホテル(滋賀県大津市)
    • Year and Date
      2015-02-05 – 2015-02-06
    • Data Source
      KAKENHI-PROJECT-26893109
  • 1.  KOKURYO TOSHIO (60378023)
    # of Collaborated Projects: 20 results
    # of Collaborated Products: 11 results
  • 2.  Nagino Masato (20237564)
    # of Collaborated Projects: 16 results
    # of Collaborated Products: 10 results
  • 3.  YOKOYAMA YUKIHIRO (80378091)
    # of Collaborated Projects: 16 results
    # of Collaborated Products: 11 results
  • 4.  Ebata Tomoki (60362258)
    # of Collaborated Projects: 12 results
    # of Collaborated Products: 4 results
  • 5.  UEHARA KEISUKE (50467320)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  FUKAYA MASAHIDE (10420382)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  IGAMI TSUYOSHI (50420378)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  MIZUNO TAKASHI (90444413)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  WATANABE Nobuyuki (20746903)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  菅原 元 (00402587)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  TSUNODA NOBUYUKI (40542684)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  Miyata Kazushi (90752759)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  ONOE Shunsuke (20807515)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  相場 利貞 (60789569)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  砂川 真輝 (50892709)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  KITAGAWA TOMOMI
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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