Yamaguchi Junpei 山口淳平

Researcher Number	00566987
Affiliation (Current)	2022: 名古屋大学, 医学部附属病院, 病院准教授
Affiliation (based on the past Project Information) *help	2020 – 2022: 名古屋大学, 医学部附属病院, 病院講師 2014 – 2020: 名古屋大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Digestive surgery / Basic Section 55020:Digestive surgery-related Except Principal Investigator Basic Section 55020:Digestive surgery-related / Digestive surgery / General surgery
Keywords	Principal Investigator 膵癌 / TFF2 / 癌抑制遺伝子 / 膵癌抑制遺伝子 / TFF1 / 前癌病変 / TFF / 癌 / 早期転移 / dormancy … More Except Principal Investigator … More ノンコーディングRNA / 胆管癌 / 融合遺伝子 / 術後肝障害 / TFF / 胆道癌 / 全ゲノム解析 / RAGE / 術後感染症 / 癌幹細胞 / TLR7 / Danger signal / 大腸癌 / システイン / 肝障害 / 肝星細胞 / エンドセリン / 敗血症性ショックモデル / 肝虚血再灌流障害 / 必須アミノ酸 / Pre-metastatic niche / TPX2 / 血管新生関連分子 / ビサボロール / 誘導体 / 核酸医薬 / 深紫外線LED / 細胞障害作用 / 癌治療 / 脂肪幹細胞 / 周術期対策 / 血中循環腫瘍細胞 / 生着関連遺伝子 / 非対称分裂 / 自己組織化 / invisible膵癌 / エクソソーム / バイオマーカー / Barrett上皮 / TFF1 / 食道癌 / Barrett食道 / barrett食道 / 食道 / 肝細胞癌 / 原発性肝癌 / TLR4 / 予防治療法 / 化学療法抵抗性 / 腹腔鏡下肝切除 / Navigation Surgery / ナビゲーション手術 / リアルタイムナビゲーションシステム / 高度侵襲消化器外科手術 / 腸内細菌叢プロファイル / 便中有機酸濃度 / バクテリアルトランスロケーション / 術後感染性合併症 / プロバイオティクス / 短鎖脂肪酸 Less

胆道癌における融合型ノンコーディングRNAの機能解明と臨床応用
- Principal Investigator
  
  國料俊男
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Nagoya University
Whole genome sequencing concerning the chemoresistance of bile duct cancer
- Principal Investigator
  
  水野隆史
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Nagoya University
消化器外科手術後感染性合併症を予防するプロバイオティクス製剤の開発
- Principal Investigator
  
  横山幸浩
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Nagoya University
The mechanisms of early dissemination and tumor dormancy of pancreatic cancerPrincipal Investigator
- Principal Investigator
  
  山口淳平
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Nagoya University
Novel treatment using adipose stem cell for postoperative liver damage
- Principal Investigator
  
  ONOE Shunsuke
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Nagoya University
Novel therapy based on engraftment, asymmetric division and Self-organization of circulating tumor cells
- Principal Investigator
  
  相場利貞
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Nagoya University
Novel diagnostic methods for invisible pancreas cancer
- Principal Investigator
  
  WATANABE Nobuyuki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Nagoya University
The role of Trefoil Factors in hepato-carcinogenesis
- Principal Investigator
  
  Ebata Tomoki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Nagoya University
Novel nucleic acid medicine for the fusion genes in cholangiocarcinoma
- Principal Investigator
  
  Nagino Masato
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Aichi Cancer Center Research Institute
  Nagoya University
Novel therapy for cancer using deep ultraviolet
- Principal Investigator
  
  Miyata Kazushi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Nagoya University
The mechanisms of cancer development from Barrett esophagus regarding Trefoil Factors.
- Principal Investigator
  
  Fukaya Masahide
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Nagoya University
Development of real-time navigation system for hepatectomy
- Principal Investigator
  
  IGAMI TSUYOSHI
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Nagoya University
The role of TFF1 to inhibit the development of pancreatic cancerPrincipal Investigator
- Principal Investigator
  
  Yamaguchi Junpei
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Nagoya University
術後肝障害に対するTLR4を標的にした予防治療法の開発
- Principal Investigator
  
  菅原元
- Project Period (FY)
  2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Nagoya University
Novel strategies for cancer stem cells
- Principal Investigator
  
  TSUNODA NOBUYUKI
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Nagoya University
Mechanism of a new cancer treatment targeting TLR7
- Principal Investigator
  
  UEHARA KEISUKE
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Nagoya University
Analysis of the inhibitory effect of cysteine on liver damage
- Principal Investigator
  
  YOKOYAMA YUKIHIRO
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Nagoya University
Novel strategies to target the premetastatic niche for cancer metastasis
- Principal Investigator
  
  MIZUNO TAKASHI
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Nagoya University
Mechanism of action of a bisabolol derivative and its clinical application
- Principal Investigator
  
  KOKURYO TOSHIO
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Nagoya University
Novel strategies targeting RAGE for postoperative infectious complications
- Principal Investigator
  
  FUKAYA MASAHIDE
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Nagoya University
The role of TFF2 as tumor suppressor for pancreatic cancerPrincipal Investigator
- Principal Investigator
  
  Yamaguchi Junpei
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Digestive surgery
- Research Institution
  Nagoya University

All 2021 2020 2019 2018 2017 2015 Other

All Journal Article Presentation Patent

[Journal Article] Trefoil factor family 2 inhibits cholangiocarcinogenesis by regulating the PTEN pathway in mice2021
- Author(s)
  Keiji Hasebe, Junpei Yamaguchi, Toshio Kokuryo, Yukihiro Yokoyama, Yosuke Ochiai, Masato Nagino and Tomoki Ebata
- Journal Title
  
  Carcinogenesis
  
  Volume: 42 (12) Pages: 1496-1505
- DOI
  10.1093/carcin/bgab093
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09141
[Journal Article] Premalignant pancreatic cells seed stealth metastasis in distant organs in mice2021
- Author(s)
  Junpei Yamaguchi, Toshio Kokuryo, Yukihiro Yokoyama, Tomoki Ebata, Yosuke Ochiai, Masato Nagino
- Journal Title
  
  Oncogene
  
  Volume: 40 Pages: 2273-2284
- DOI
  10.1038/s41388-021-01706-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03751
[Journal Article] Trefoil Factor Family 1 Inhibits the Development of Hepatocellular Carcinoma by Regulating β-Catenin Activation2020
- Author(s)
  Ochiai Y, Yamaguchi J, Kokuryo T, Yokoyama Y, Ebata T, Nagino M
- Journal Title
  
  Hepatology
  
  Volume: - Pages: 503-517
- DOI
  10.1002/hep.31039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09141
[Journal Article] Trefoil Factor 1 inhibits epithelial-mesenchymal transition of pancreatic intraepithelial neoplasm.2018
- Author(s)
  Yamaguchi J, Yokoyama Y, Kokuryo T, Ebata T, Enomoto A, Nagino M.
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 128(8) Pages: 3619-3629
- DOI
  10.1172/jci97755
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10695
[Journal Article] Trefoil factor family 1 expression in the invasion front is a poor prognostic factor associated with lymph node metastasis in pancreatic cancer2017
- Author(s)
  Masaki Sunagawa, Junpei Yamaguchi, Toshio Kokuryo, Tomoki Ebata, Yukihiro Yokoyama, Gen Sugawara, Masato Nagino
- Journal Title
  
  Pancreatology
  
  Volume: 17 (5) Pages: 782-787
- DOI
  10.1016/j.pan.2017.07.188
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10695
[Patent] TFF1による消化器癌の化学療法感受性増強法2020
- Inventor(s)
  山口淳平
- Industrial Property Rights Holder
  名古屋大学
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-20H03751
[Presentation] Trefoil Factor Family 1 (TFF1) Inhibits Epithelial-mesenchymal Transition and Enhances the Chemosensitivity of Pancreatic Ductal Adenocarcinoma (PDAC)2019
- Author(s)
  J Yamaguchi, T Kokuryo, Y Yokoyama, T Ebata, and M Nagino
- Organizer
  APA annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10695
[Presentation] Trefoil Factor Family 1 Inhibits the Development of Hepatocellular Carcinoma by Regulating β-Catenin Activation.2019
- Author(s)
  Ochiai Y, Yamaguchi J, Kokuryo T, Yokoyama Y, Ebata T, Nagino M
- Organizer
  The Liver Meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09141
[Presentation] Trefoil Factor 1 inhibits epithelial-mesenchymal transition (EMT) of pancreatic intraepithelial neoplasm.2018
- Author(s)
  Junpei Yamaguchi, Yukihiro Yokoyama, Toshio Kokuryo and Masato Nagino
- Organizer
  AACR Pancreatic cancer: advances in science and clinical care
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10695
[Presentation] 2-Hydroxypropyl-beta-cyclodextrin encapsulated α-bisabolol (CD-BSB) improves the antitumor effect of α-bisabolol for pancreatic cancer2018
- Author(s)
  Taisuke Baba, Toshio Kokuryo , Yukihiro Yokoyama, Junpei Yamaguchi, Masato Nagino
- Organizer
  the AACR’s fifth Pancreatic Cancer Special Conference: Advances in Science and Clinical Care
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10591
[Presentation] Preserved expression of TFF1 in invasive front is a poor prognostic factor in PDAC2017
- Author(s)
  Junpei Yamaguchi, Masaki Sunagawa, Yukihiro yokoyama, Toshio Kokuryo, Tomoki Ebata, Masato Nagino
- Organizer
  Joint Congress of The 6th Biennial Congress of the Asian-Pacific Hepato-Pancreato-Biliary Association &　The 29th Meeting of Japanese Society of Hepato-Biliary-Pancreatic Surgery
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10695
[Presentation] 遺伝子改変マウスを用いたTFF1欠損による膵浸潤癌発生に関する検討2017
- Author(s)
  山口淳平、江畑智希、横山幸浩、國料俊男、梛野正人
- Organizer
  第48回日本膵臓学会大会
- Data Source
  KAKENHI-PROJECT-17K10695
[Presentation] 膵癌に対するTrefoil Factor Family 2 (TFF2)の抗腫瘍効果の検討2015
- Author(s)
  山口淳平、S.P. Thayer, A.L. Warshaw、江畑智希、横山幸弘、國料俊男、伊神剛、菅原元、水野隆司、梛野正人
- Organizer
  第70回日本消化器外科学会総会
- Place of Presentation
  静岡県浜松市　アクトシティ浜松
- Year and Date
  2015-07-15
- Data Source
  KAKENHI-PROJECT-26893109
[Presentation] Trefoil Family Factor 2 (TFF2)抑制による膵IPMN発生マウスモデルの検討2015
- Author(s)
  山口淳平、S.P. Thayer, A.L. Warshaw、江畑智希、横山幸弘、國料俊男、梛野正人
- Organizer
  第115回日本外科学会定期学術集会
- Place of Presentation
  愛知県名古屋市　名古屋国際会議場
- Year and Date
  2015-04-16
- Data Source
  KAKENHI-PROJECT-26893109
[Presentation] TFF2 (Trefoil Factor Family 2)の膵癌抑制効果の検討
- Author(s)
  山口淳平、S. P. Thayer、A. L. Warshaw、江畑智希、横山幸浩、國料俊男、梛野正人
- Organizer
  個体レベルでのがん研究支援活動ワークショップ
- Place of Presentation
  琵琶湖ホテル（滋賀県大津市）
- Year and Date
  2015-02-05 – 2015-02-06
- Data Source
  KAKENHI-PROJECT-26893109

1. KOKURYO TOSHIO (60378023)

# of Collaborated Projects: 20 results

# of Collaborated Products: 11 results
2. Nagino Masato (20237564)

# of Collaborated Projects: 16 results

# of Collaborated Products: 10 results
3. YOKOYAMA YUKIHIRO (80378091)

# of Collaborated Projects: 16 results

# of Collaborated Products: 11 results
4. Ebata Tomoki (60362258)

# of Collaborated Projects: 12 results

# of Collaborated Products: 4 results
5. UEHARA KEISUKE (50467320)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. FUKAYA MASAHIDE (10420382)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. IGAMI TSUYOSHI (50420378)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. MIZUNO TAKASHI (90444413)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. WATANABE Nobuyuki (20746903)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 菅原元 (00402587)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. TSUNODA NOBUYUKI (40542684)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Miyata Kazushi (90752759)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. ONOE Shunsuke (20807515)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 相場利貞 (60789569)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 砂川真輝 (50892709)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. KITAGAWA TOMOMI

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Yamaguchi Junpei 山口 淳平

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The role of TFF1 to inhibit the development of pancreatic cancerPrincipal Investigator

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Yamaguchi Junpei 山口淳平