Kobayashi Takashi 小林恭

Researcher Number	00642406
Other IDs
Affiliation (Current)	2025: 京都大学, 医学研究科, 教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 京都大学, 医学研究科, 教授 2020: 京都大学, 医学研究科, 准教授 2019: 京都大学, 医学研究科, 講師 2016 – 2017: 京都大学, 医学研究科, 助教 2016: 京都大学, 医学研究科, 特定病院助教 2013 – 2016: 京都大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 56030:Urology-related / Urology Except Principal Investigator Urology / Basic Section 56030:Urology-related / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Basic Section 49020:Human pathology-related / Basic Section 55010:General surgery and pediatric surgery-related
Keywords	Principal Investigator 膀胱癌 / がん免疫療法 / 癌免疫療法 / オルガノイド / CRISPR/Cas9 / 遺伝子改変マウス / マウスモデル / 浸潤性膀胱癌 / 全エクソームシーケンス / 全エクソームシークエンス … More / lineage tracing / マウス発癌モデル / 発癌 / 動物モデル … More Except Principal Investigator 前立腺癌 / バイオマーカー / 膀胱癌 / 新規治療開発 / エピゲノム解析 / 切除不能尿路上皮がん / 免疫チェックポイント阻害剤 / 生体イメージング / 癌免疫療法 / シングルセル核シーケンス / ロングリードシーケンス / 多重免疫染色 / 単一細胞核シーケンス / ロングリードRNAシーケンス / 分子サブタイプ / 患者由来ゼノグラフト / 相同組換え修復関連遺伝子 / CDK12 / PDX / PARP阻害薬 / ATM阻害薬 / 去勢抵抗性前立腺癌 / CDK12異常前立腺癌 / 人工知能システム / intraductal carcinoma / 放射線治療 / 免疫染色 / 予後因子 / 治療奏功予測 / 予後不良因子 / 人工知能 / TMPRSS2-ERG融合遺伝子 / PTEN欠失 / 導管内癌 / radiation therapy / artificial intelligence / Japanese patient / PTEN loss / radiation / pathology / IDC-P / prostate cancer / 抗体関連拒絶 / 造血幹細胞移植 / エピトープ / 抗HLA抗体 / HLA / 抗ドナー抗体 / epitope / eplet / 臓器移植 / biomarker / 薬剤感受性 / 癌 / ctDNA / 腎癌 / 循環腫瘍DNA / 循環腫瘍細胞 / cfDNA / CTC / 細胞老化 / 頻尿 / シクロホスファミド誘発性膀胱炎 / コネキシン43 / ギャップジャンクション Less

次世代遺伝子発現解析法に立脚したシーケンスレスながん分子サブタイプ規定法の開発
- Principal Investigator
  
  赤松秀輔
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Nagoya University
同所性同種膀胱癌モデルマウスを用いた免疫チェックポイント阻害剤感受性因子の解明
- Principal Investigator
  
  佐野剛視
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Kansai Medical University
尿路上皮がんに対する新規エピゲノム解析による治療効果予測バイオマーカー開発
- Principal Investigator
  
  西山直隆
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  University of Toyama
患者由来ゼノグラフトを用いたCDK12変異前立腺癌のPARP阻害薬不応性の克服
- Principal Investigator
  
  後藤崇之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Kyoto University
Elucidation of bladder carcinogenesis mechanism and modeling of immunotherapy by gene-modified urothelial organoidsPrincipal Investigator
- Principal Investigator
  
  小林恭
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Kyoto University
Development of novel biomarkers based on HLA epitopes for organ transplantation and hematopoietic stem cell transplantation
- Principal Investigator
  
  Yagi Shintaro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Kanazawa University
Application of artificial intelligence to molecular biological characteristics of prostate ductal carcinoma and treatment prediction
- Principal Investigator
  
  Tsuzuki Toyonori
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Aichi Medical University
Establishment of a novel mouse model that recapitulates human muscle invasive bladder cancerPrincipal Investigator
- Principal Investigator
  
  Kobayashi Takashi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Kyoto University
Development of predictive markers for drug-susceptibility in blood by genomic analysis using PDX models
- Principal Investigator
  
  Kamba Tomomi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Urology
- Research Institution
  Kumamoto University
  Kyoto University
CXCL1を介した膀胱癌微小環境制御機構とそれに伴う腔内再発・進展機序の解明
- Principal Investigator
  
  松井喜之
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kyoto University
Elucidation of novel carcinogenesis / development pathway of bladder cancer by using metabolism-related omics analysis
- Principal Investigator
  
  Terada Naoki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kyoto University
ギャップジャンクションに着目した新たな頻尿治療ターゲットの探求
- Principal Investigator
  
  吉村耕治
- Project Period (FY)
  2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kyoto University
Development of new animal model of invasive bladder cancer based on new generation OMICS analysis between speciesPrincipal Investigator
- Principal Investigator
  
  Kobayashi Takashi
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Urology
- Research Institution
  Kyoto University

All 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Clinical significance of <scp>IDC‐P</scp> as predictive factor after intensity‐modulated radiation therapy2022
- Author(s)
  Aizawa Rihito、Tsuzuki Toyonori、Haga Hironori、Nakamura Kiyonao、Ogata Takashi、Inoue Takahiro、Kobayashi Takashi、Akamatsu Shusuke、Goto Takayuki、Ogawa Osamu、Mizowaki Takashi
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 7 Pages: 2425-2433
- DOI
  10.1111/cas.15392
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06933, KAKENHI-PROJECT-20K09539
[Journal Article] Microsurgery training during COVID‐19 pandemic: Practical recommendations from the International Society for Experimental Microsurgery and International Microsurgery Simulation Society2021
- Author(s)
  Oltean Mihai、Nistor Alexandru、Hellstroem Mats、Axelsson Michael、Yagi Shintaro、Kobayashi Eiji、Ballestin Alberto、Akelina Yelena、Nemeth Norbert
- Journal Title
  
  Microsurgery
  
  Volume: 41 Issue: 4 Pages: 398-400
- DOI
  10.1002/micr.30725
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22656, KAKENHI-PROJECT-21H02985
[Journal Article] Micro- and macro-borderless surgery using a newly developed high-resolution (4K) three-dimensional video system2021
- Author(s)
  Yagi Shintaro、Ito Takashi、Shirai Hisaya、Yao Siyuan、Masano Yuki、Ogawa Eri、Gabata Ryosuke、Uemoto Shinji、Kobayashi Eiji
- Journal Title
  
  PLOS ONE
  
  Volume: 16 Issue: 5 Pages: e0250559-e0250559
- DOI
  10.1371/journal.pone.0250559
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22656, KAKENHI-PROJECT-21H02985
[Journal Article] Enhancement of transduction efficiency using Adeno-associated viral vectors by chemical pretreatment to mice bladder urothelium2020
- Author(s)
  Hamada Akihiro、Kita Yuki、Murakami Kaoru、Matsumoto Keiyu、Sakatani Toru、Sano Takeshi、Ogawa Osamu、Kobayashi Takashi
- Journal Title
  
  Journal of Virological Methods
  
  Volume: 279 Pages: 113854-113854
- DOI
  10.1016/j.jviromet.2020.113854
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03790
[Presentation] Elucidation of the tumorigenic mechanism with a novel bladder cancer syngeneic mouse model using gene-edited organoids derived from bladder epithelium2023
- Author(s)
  Akihiro Hamada*, Yuki Kita, Takeshi Sano, Ryosuke Ikeuchi, Hideaki Takada, Kenji Nakamura, Toru Sakatani, Takayuki Goto, Atsuro Sawada, Shusuke Akamatsu, Takashi Kobayashi
- Organizer
  第110回日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-23K24470
[Presentation] 遺伝子改変マウスの膀胱上皮由来オルガノイドを用いた膀胱癌同系モデルの樹立2022
- Author(s)
  濱田彬弘、北悠希、佐野剛視、高田秀明、中村健治、酒谷徹、後藤崇之、赤松秀輔、小林恭
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K24470
[Presentation] Establishment of a bladder cancer model using organoids derived from bladder epithelium in genetically engineered mice2022
- Author(s)
  Akihiro Hamada; Yuki Kita; Hideaki Takada; Kenji Nakamura; Toru Sakatani; Takeshi Sano; Takayuki Goto; Atsuro Sawada; Shusuke Akamatsu; Takashi Kobayashi
- Organizer
  AACR ANNUAL MEETING 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24470

1. 小川修 (90260611)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
2. Terada Naoki (60636637)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 松井喜之 (00582107)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 山崎俊成 (00607749)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 羽賀博典 (10252462)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
6. 赤松秀輔 (20767248)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 北悠希 (90647455)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
8. 佐野剛視 (60866309)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
9. Kamba Tomomi (20402836)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. Yagi Shintaro (60447969)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. Tsuzuki Toyonori (70627645)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 吉村耕治 (40397542)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 杉野善雄 (00607525)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 元島崇信 (60726355)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 中村英二郎 (90293878)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 吉野喬之 (40734348)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 伊藤孝司 (10378656)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 進藤岳郎 (10646706)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 田中里奈 (80847517)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 山本陽一朗 (00573247)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 佐々直人 (50437026)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 高原大志 (50790317)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 溝脇尚志 (90314210)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
24. 後藤崇之 (90806605)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 藤本明洋 (30525853)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 住吉崇幸 (30846100)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 村川泰裕 (50765469)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 北野滋久 (60402682)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 西山直隆 (70619030)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 金井弥栄 (00260315)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 北村寛 (00404674)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 新井恵吏 (40446547)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kobayashi Takashi 小林 恭

Research Projects

Research Products

Co-Researchers

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of bladder carcinogenesis mechanism and modeling of immunotherapy by gene-modified urothelial organoidsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of a novel mouse model that recapitulates human muscle invasive bladder cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of new animal model of invasive bladder cancer based on new generation OMICS analysis between speciesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Clinical significance of <scp>IDC‐P</scp> as predictive factor after intensity‐modulated radiation therapy2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Microsurgery training during COVID‐19 pandemic: Practical recommendations from the International Society for Experimental Microsurgery and International Microsurgery Simulation Society2021

Author(s)

Journal Title

Kobayashi Takashi 小林恭