Ishigaki Kazuyoshi 石垣和慶

Researcher Number	00790338
Other IDs
Affiliation (Current)	2025: 慶應義塾大学, 医学部(信濃町), 教授 2025: 国立研究開発法人理化学研究所, 生命医科学研究センター, チームディレクター
Affiliation (based on the past Project Information) *help	2021 – 2024: 国立研究開発法人理化学研究所, 生命医科学研究センター, チームリーダー
Review Section/Research Field	Principal Investigator Basic Section 54020:Connective tissue disease and allergy-related / 0701:Biology at molecular to cellular levels, and related fields Except Principal Investigator Basic Section 54020:Connective tissue disease and allergy-related / Basic Section 56060:Ophthalmology-related / Medium-sized Section 90:Biomedical engineering and related fields
Keywords	Principal Investigator 自己免疫疾患 / ゲノム編集 / リスク多型 / ゲノム医療 / サイトカイン / 抗サイトカイン療法 / ゲノムワイド関連解析 / アレル特異的発現解析 / アレル特異的解析 / 転写因子 / GWAS … More Except Principal Investigator … More I型IFN / 全身性エリテマトーデス / ループス腎炎 / ポドサイト / 老化細胞 / ニコチナミドモノヌクレオチド / 環境 / 角膜移植 / 角膜内皮細胞 / 虹彩萎縮 / 前房関連角膜内皮症 / 治療薬 / 細胞老化 / 前房環境 / 難治性水疱性角膜症 / がん免疫療法 / NK細胞 / ナノDDS / 薬物送達学 Less

ナノDDSによる生体内機能強化NK細胞の創出と新規がん免疫療法基盤の構築
- Principal Investigator
  
  中村孝司
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Hokkaido University
Establishment of experimental basis to improve the prognosis of corneal transplantation in treating bullous keratoplasty due to pathological aqueous humor.
- Principal Investigator
  
  山口剛史
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Tokyo Dental College
老化細胞の蓄積を起因とするループス腎炎の病態形成と治療標的分子の解明
- Principal Investigator
  
  一瀬邦弘
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Shimane University
自己免疫疾患のリスク多型機能解析による個別化抗サイトカイン療法の確立Principal Investigator
- Principal Investigator
  
  石垣和慶
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Institute of Physical and Chemical Research
Identification of transcription factor controlling autoimmunity risk allele's pathogenic functionPrincipal Investigator
- Principal Investigator
  
  Ishigaki Kazuyoshi
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0701:Biology at molecular to cellular levels, and related fields
- Research Institution
  Institute of Physical and Chemical Research

All 2024 2023 2022

All Journal Article Presentation Patent

[Journal Article] The genetic basis of autoimmunity seen through the lens of T cell functional traits2024
- Author(s)
  Lagattuta Kaitlyn A.、Park Hannah L.、Rumker Laurie、Ishigaki Kazuyoshi、Nathan Aparna、Raychaudhuri Soumya
- Journal Title
  
  Nature Communications
  
  Volume: 15 Issue: 1
- DOI
  10.1038/s41467-024-45170-w
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24373
[Journal Article] Identification of a regulatory pathway governing TRAF1 via an arthritis-associated non-coding variant2024
- Author(s)
  Wang Qiang、Martnez-Bonet Marta、Kim Taehyeung、Sparks Jeffrey A.、Ishigaki Kazuyoshi. et. al.
- Journal Title
  
  Cell Genomics
  
  Volume: 4 Issue: 2 Pages: 100502-100502
- DOI
  10.1016/j.xgen.2024.100502
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24373
[Journal Article] Immunomics analysis of rheumatoid arthritis identified precursor dendritic cells as a key cell subset of treatment resistance.2023
- Author(s)
  Yamada S, Nagafuchi Y, Wang M, Ota M, Hatano H, Takeshima Y, Okubo M, Kobayashi S, Sugimori Y, Masahiro N, Yoshida R, Hanata N, Suwa Y, Tsuchida Y, Iwasaki Y, Sumitomo S, Kubo K, Shimane K, Setoguchi K, Azuma T, Kanda H, Shoda H, Zhang X, Yamamoto K, Ishigaki K, Okamura T, Fujio K
- Journal Title
  
  Ann Rheum Dis
  
  Volume: Epub ahead of print Issue: 6 Pages: 1-11
- DOI
  10.1136/ard-2022-223645
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24369, KAKENHI-PROJECT-23K24373, KAKENHI-PROJECT-22K15493
[Journal Article] Genome-wide association study reveals BET1L associated with survival time in the 137,693 Japanese individuals2023
- Author(s)
  Akiyama Masato、Sakaue Saori、Takahashi Atsushi、Ishigaki Kazuyoshi、Hirata Makoto、Matsuda Koichi、Momozawa Yukihide、Okada Yukinori、Ninomiya Toshiharu、Koido Masaru、Morisaki Takayuki、Nagai Akiko、Sagiya Yoji、Terao Chikashi、Murakami Yoshinori、Kubo Michiaki、Kamatani Yoichiro、The Biobank Japan project
- Journal Title
  
  Communications Biology
  
  Volume: 6 Issue: 1 Pages: 143-143
- DOI
  10.1038/s42003-023-04491-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K20647, KAKENHI-PROJECT-23K24373, KAKENHI-PROJECT-23K24468, KAKENHI-PROJECT-23K24602
[Journal Article] Functional Genetics to Understand the Etiology of Autoimmunity2023
- Author(s)
  Hatano Hiroaki、Ishigaki Kazuyoshi
- Journal Title
  
  Genes
  
  Volume: 14 Issue: 3 Pages: 572-572
- DOI
  10.3390/genes14030572
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K20647, KAKENHI-PROJECT-23K24373
[Journal Article] Control of naive and effector CD4 T cell receptor repertoires by rheumatoid-arthritis-risk HLA alleles2022
- Author(s)
  Nagafuchi Yasuo、Ota Mineto、Hatano Hiroaki、Inoue Mariko、Kobayashi Satomi、Okubo Mai、Sugimori Yusuke、Nakano Masahiro、Yamada Saeko、Yoshida Ryochi、Tsuchida Yumi、Iwasaki Yukiko、Shoda Hirofumi、Okada Yukinori、Yamamoto Kazuhiko、Ishigaki Kazuyoshi、Okamura Tomohisa、Fujio Keishi
- Journal Title
  
  Journal of Autoimmunity
  
  Volume: 133 Pages: 102907-102907
- DOI
  10.1016/j.jaut.2022.102907
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K16283, KAKENHI-PROJECT-20K08800, KAKENHI-PROJECT-21K20647, KAKENHI-PROJECT-23K24369, KAKENHI-PROJECT-23K24373
[Journal Article] Prediction of the cell-type-specific transcription of non-coding RNAs from genome sequences via machine learning2022
- Author(s)
  Koido Masaru、Hon Chung-Chau、Koyama Satoshi、Kawaji Hideya、Murakawa Yasuhiro、Ishigaki Kazuyoshi、Ito Kaoru、Sese Jun、Parrish Nicholas F.、Kamatani Yoichiro、Carninci Piero、Terao Chikashi
- Journal Title
  
  Nature Biomedical Engineering
  
  Volume: Online Issue: 6 Pages: 830-844
- DOI
  10.1038/s41551-022-00961-8
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KF0209, KAKENHI-PROJECT-20K15773, KAKENHI-PROJECT-21K20647, KAKENHI-PROJECT-20H00462, KAKENHI-PROJECT-23K24373
[Journal Article] Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis2022
- Author(s)
  Ishigaki K, Sakaue S, Terao C, Luo Y, Sonehara KvYamaguchi K, Amariuta T, Too CL, Laufer VA, Scott IC, Viatte S, Takahashi M, Ohmura K, Murasawa A, Hashimoto M, Ito H, ..., Okada Y et al.
- Journal Title
  
  Nature Genetics
  
  Volume: 54 Issue: 11 Pages: 1640-1651
- DOI
  10.1038/s41588-022-01213-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H00476, KAKENHI-PROJECT-20H03722, KAKENHI-PROJECT-21K19501, KAKENHI-PROJECT-21K20647, KAKENHI-PROJECT-23K24373, KAKENHI-PROJECT-23K24465, KAKENHI-PROJECT-22H04923
[Journal Article] Distinct transcriptome architectures underlying lupus establishment and exacerbation2022
- Author(s)
  Nakano Masahiro　et al.
- Journal Title
  
  Cell
  
  Volume: 185 Issue: 18 Pages: 3375-3389.e21
- DOI
  10.1016/j.cell.2022.07.021
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05285, KAKENHI-PROJECT-21H02960, KAKENHI-PROJECT-20K08800, KAKENHI-PROJECT-21K20647, KAKENHI-PROJECT-23K24373
[Journal Article] Splicing QTL analysis focusing on coding sequences reveals mechanisms for disease susceptibility loci2022
- Author(s)
  Yamaguchi Kensuke、Ishigaki Kazuyoshi、Suzuki Akari、Tsuchida Yumi、Tsuchiya Haruka、Sumitomo Shuji、Nagafuchi Yasuo、Miya Fuyuki、Tsunoda Tatsuhiko、Shoda Hirofumi、Fujio Keishi、Yamamoto Kazuhiko、Kochi Yuta
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 4659-4659
- DOI
  10.1038/s41467-022-32358-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05285, KAKENHI-PROJECT-20K08800, KAKENHI-PROJECT-21K19501, KAKENHI-PROJECT-21K20647, KAKENHI-PROJECT-23K23860, KAKENHI-PROJECT-23K24373
[Journal Article] Single-cell eQTL models reveal dynamic T cell state dependence of disease loci2022
- Author(s)
  Nathan Aparna、Asgari Samira、Ishigaki Kazuyoshi、Valencia Cristian、Amariuta Tiffany、Luo Yang、Beynor Jessica I.、Baglaenko Yuriy、Suliman Sara、Price Alkes L.、Lecca Leonid、Murray Megan B.、Moody D. Branch、Raychaudhuri Soumya
- Journal Title
  
  Nature
  
  Volume: 606 Issue: 7912 Pages: 120-128
- DOI
  10.1038/s41586-022-04713-1
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K20647, KAKENHI-PROJECT-23K24373
[Journal Article] HLA autoimmune risk alleles restrict the hypervariable region of T cell receptors2022
- Author(s)
  Ishigaki Kazuyoshi、Lagattuta Kaitlyn A.、Luo Yang、James Eddie A.、Buckner Jane H.、Raychaudhuri Soumya
- Journal Title
  
  Nature Genetics
  
  Volume: 54 Issue: 4 Pages: 393-402
- DOI
  10.1038/s41588-022-01032-z
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K20647, KAKENHI-PROJECT-23K24373
[Patent] 改良されたＡＴＡＣ－ｓｅｑ法及びキット2023
- Inventor(s)
  石垣　和慶
- Industrial Property Rights Holder
  石垣　和慶
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-084002
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-23K24373
[Presentation] Chromatin interaction inferences based on the paired transcriptome and chromatin accessibility datasets identify candidate risk genes of autoimmunity.2023
- Author(s)
  Hatano H., Suzuki A., Nakano M., Oguchi A., Murakawa Y., Terao C., Yamamoto K., Ishigaki K
- Organizer
  American Society of Human Genetics Annual Meeting 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24373
[Presentation] Autoimmunity risk variants exert dynamic allelic effects on the chromosome accessibility of stimulated CD4+ T cells.2023
- Author(s)
  Kono M., Hatano H., Suzuki A., Nakano M., Oguchi A., Murakawa Y., Terao C., Yamamoto K., Ishigaki K
- Organizer
  American Society of Human Genetics Annual Meeting 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24373
[Presentation] An efficient functional assay platform of autoimmunity risk alleles using CRISPR genome editing.2023
- Author(s)
  Kono M., Arakawa T., Nakano M., Hatano H., Ishigaki K.
- Organizer
  Annual Meeting of the Federation of Clinical Immunology Societies 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24373
[Presentation] Autoimmunity pathology elucidated by functional genetics studies2023
- Author(s)
  石垣和慶
- Organizer
  日本人類遺伝学会第68回大会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24373
[Presentation] Actively transcribed regulatory regions explain the genetic risk of rheumatoid arthritis2022
- Author(s)
  Hiroaki Hatano, Akari Suzuki, Matteo Guerrini, Michihiro Kono, Masahiro Nakano, Akiko Oguchi, Chikashi Terao,Yasuhiro Murakawa, Kazuhiko Yamamoto, Kazuyoshi Ishigaki
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24373
[Presentation] Actively transcribed regulatory regions explain the genetic risk of rheumatoid arthritis2022
- Author(s)
  Hiroaki Hatano、Kazuyoshi Ishigaki、ら
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21K20647

1. 中村孝司 (20604458)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 佐藤悠介 (10735624)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 山野友義 (40724183)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 山口剛史 (20383771)

# of Collaborated Projects: 1 results

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5. 金蔵孝介 (10508568)

# of Collaborated Projects: 1 results

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6. 植田幸嗣 (10509110)

# of Collaborated Projects: 1 results

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7. 比嘉一成 (60398782)

# of Collaborated Projects: 1 results

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8. 野間久史 (70633486)

# of Collaborated Projects: 1 results

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9. 吉野純 (80383777)

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10. 一瀬邦弘 (60437895)

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11. 井川敬 (80782581)

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12. OKAMURA Tomohisa

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13. SUZUKI Akari

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# of Collaborated Products: 1 results
14. SHODA Hirofumi

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15. 小林聖未

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16. 村川泰裕

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17. 岡田随象

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18. 山本一彦

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Ishigaki Kazuyoshi 石垣 和慶

Research Projects

Research Products

Co-Researchers

ナノDDSによる生体内機能強化NK細胞の創出と新規がん免疫療法基盤の構築

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of experimental basis to improve the prognosis of corneal transplantation in treating bullous keratoplasty due to pathological aqueous humor.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

老化細胞の蓄積を起因とするループス腎炎の病態形成と治療標的分子の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

自己免疫疾患のリスク多型機能解析による個別化抗サイトカイン療法の確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of transcription factor controlling autoimmunity risk allele's pathogenic functionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] The genetic basis of autoimmunity seen through the lens of T cell functional traits2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of a regulatory pathway governing TRAF1 via an arthritis-associated non-coding variant2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Immunomics analysis of rheumatoid arthritis identified precursor dendritic cells as a key cell subset of treatment resistance.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genome-wide association study reveals BET1L associated with survival time in the 137,693 Japanese individuals2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Functional Genetics to Understand the Etiology of Autoimmunity2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Control of naive and effector CD4 T cell receptor repertoires by rheumatoid-arthritis-risk HLA alleles2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prediction of the cell-type-specific transcription of non-coding RNAs from genome sequences via machine learning2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Distinct transcriptome architectures underlying lupus establishment and exacerbation2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Splicing QTL analysis focusing on coding sequences reveals mechanisms for disease susceptibility loci2022

Ishigaki Kazuyoshi 石垣和慶