YAMASHITA Takayuki 山下孝之

… Alternative Names

YAMASHITA Tasutoshi 山下孝之

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Researcher Number	10166671
Other IDs
Affiliation (based on the past Project Information) *help	2019 – 2020: 群馬大学, 生体調節研究所, 教授 2007 – 2017: 群馬大学, 生体調節研究所, 教授 2004 – 2005: 群馬大学, 生体調節研究所, 教授 2003: The University of Tokyo, The Institute of Medical Science, Teaching Staff of Donation Laboratory, 医科学研究所, 寄付研究部門教員(常勤形態) 2003: 東京大学, 医科学研究所・寄付研究部門教員(常勤・客員助教授) … More 2002: 東京大学, 医科学研究所, 客員助教授 2000: Institute of Medical Science, The University of Tokyo Visiting Associate Professor, 医科学研究所, 客員助教授 2000: Institute of Medical Science, University of Tokyo Department of Pathological Pharmacology, Research Associate, 医科学研究所・病態薬理学, 助手 1996 – 1999: 東京大学, 医科学研究所, 助手 1990 – 1992: 東京大学, 医学部(分), 助手 1988 – 1989: 東京大学, 医学部, 助手 1986 – 1988: Kobe University, Faculty of Medicine, Research Associate, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Biological Sciences / Hematology / Biological Sciences / Hematology / Basic Section 50020:Tumor diagnostics and therapeutics-related / Tumor biology / Carcinogenesis Except Principal Investigator 物質生物化学 / General medical chemistry / Tumor therapeutics / Tumor biology / 内分泌・代謝学
Keywords	Principal Investigator ファンコニ貧血 / 骨髄異形成症候群 / ゲノム不安定性 / DNA複製 / Fanconi anemia / Yファミリー・ポリメラーゼ / 白血病 / Fanconi貧血 / 発がん遺伝子 / 突然変異 … More / 複製ストレス / DNA修復 / 再生不良性貧血 / FAC / DNA複製ストレス / DNA損傷 / reversion / 蛋白相互作用 / 染色体不安定性 / がん遺伝子 / DNA repair / 骨髄不全 / 蛋白リン酸化酵素 / リン酸化 / ファンユニ貧血 / FAA / DNAポリメラーゼ / geminin / 前がん病変 / ゲノム不安定化 / 発がん / Y-family polymerase / DNA再複製 / 損傷乗り越えDNA合成 / プロテアソーム / ユビキチン化 / シャペロン / 核輸送 / ユビキチン・リガーゼ / 骨髄性白血病 / cdc2 / 細胞周期 / アクチビン / HLー60細胞 / アクチビンA / 細胞老化 / グアニン四重鎖構造安定化剤 / 細胞死 / ポリメラーゼeta / グアニン四重鎖構造 / ポリメラーゼeta(Pol-eta) / c-Myc遺伝子 / 複製フォーク / エンドヌクレアーゼ / DNAポリメラーゼeta / 合成致死 / ポリメラーゼ・イータ / MUS81 / 損傷乗り越えポリメラーゼ / Myc / tumor suppressor gene / methylation / somatic mosaicism / genetic reversion / bone marrow failure / がん抑制遺伝子 / メチル化 / 体細胞モザイク / 復帰変異 / nuclear transport / protein interaction / ubiquitin ligase / 熱ショック蛋白 / leukemia / myelodysplastic syndrome / chromosome instability / 急性骨髄性白血病 / Protein kinase / Phosphorylation / Chromosome instability / Leukemia / ファンコン貧血 / Protein to protein interaction / Protein phosphorylation / 蛋白リン酸化 / cyclin E / 分子シャペロン / モノユビキチン化PCNA / DNAポリメラーゼη / Yファミリーポリメラーゼ / 造血不全 / Hsp90 / 損傷乗越えDNA合成 / 高発がん / 悪性腫瘍 / Platelet-derivol growth factor(PDGF) / Fibroblast grawth factor(FGF) / Interleukin-1 / Tumor necrosis factor / 骨髄ストローマ細胞 / interleukinー1 / tumor necrosis factor / ホルボルエステル / 骨髄ストロ-マ細胞 / 巨核球系分化 / 赤芽球系分化 / フレンド白血病細胞 / 細胞分化 / 活性型ビタミンD / インタ-フェロンγ / THPー1細胞 / マウスフレンド白血病細胞 / erythroid differentiation factor(EDF) / インターフェロンーgamma / 赤芽球 / 巨核球 / トロンボキサン / HMBA(Hexamethylene Bis acetamide) / マウスフレンド細胞 … More Except Principal Investigator Cキナーゼ / ホスホリパーゼC / GTP結合蛋白質 / 細胞増殖因子 / 受容体 / イノシトールリン脂質 / ジグリセリド / カルシウムイオン / 複製ストレス / 細胞膜受容体 / シナプス / 癌遺伝子 / サイクリックAMP / プロテインキナーゼ / p53 / 細胞老化 / HSF1 / HSP90 / DNA損傷 / DHRS2 / MDM2 / がん遺伝子 / 発がんシグナル / y-familyポリメラーゼ / MUS81-EME2 / synthetic lethality / Mus81-EME2 / Y-family Polymerase / c-Myc / 合成致死 / Mus81 and EME2 / Polymerase η / Y-familyポリメラーゼ / 発がん性複製ストレス / Protein Kinase C / GTP-binding Protein / Phospholipase C / Cell Surface Receptor / Phosphoinositide / イノシトール三リン酸 / Protein Kinases / Calcium Ion / Cyclic AMP / Intracellular Messengers / Nuclear Genes / Cell Surface Receptors / 細胞内伝達系 / 核遺伝子 / 百日咳毒素 / 副甲状腺ホルモン様蛋白 / G蛋白 / イオンチャンネル / HHM因子 / 成長因子 / ホルモン不応症 / カルシウム / 遺伝子発現 / 情報伝達系 / C-rasp21 / cyclic AMP / Ca^<2+> / 動脈硬化 / 細胞周期 / 細胞増殖 / 発がんプロモーター / イノシトールリン脂質代謝 / 血管平滑筋細胞 / 神経活性物質 / イノシトールリン酸 / 発癌プロモーター / ストレス / Y-family polymerases / 損傷乗越えDNA合成 / HSP / p21 / 熱ショック応答 / 損傷乗越え DNA 合成 / DNA 損傷 / 癌 / 遺伝子 / 遺伝子変異 / Hsp90 / がん / 遺伝子突然変異 / 損傷乗り越えDNA合成 Less

発がんシグナル誘導性複製ストレスへの応答機構を標的とする治療開発Principal Investigator
- Principal Investigator
  
  山下孝之
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Gunma University
The role of Y-family polymerase in aberrant DNA replication and genomic instabilityPrincipal Investigator
- Principal Investigator
  
  Yamashita Takayuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Gunma University
Analysis of oncogene-induced replication stress response patyways
- Principal Investigator
  
  Sekimoto Takayuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Gunma University
Molecular basis for the development of anti-tumor therapy by targeting HSF1.
- Principal Investigator
  
  Oda Tsukasa
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Gunma University
がん遺伝子が誘導する複製ストレス応答におけるY-familyポリメラーゼの役割Principal Investigator
- Principal Investigator
  
  山下孝之
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Gunma University
発がんシグナルが誘導するＤＮＡ複製異常におけるＹ－ｆａｍｉｌｙポリメラーゼの役割Principal Investigator
- Principal Investigator
  
  山下孝之
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Gunma University
Roles of replication stress for cellular senescence and genome instability in preneoplastic lesionsPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Takayuki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Carcinogenesis
- Research Institution
  Gunma University
Regulation of the DNA damage response mediated by the heat shock response
- Principal Investigator
  
  ODA Tsukasa
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Gunma University
New understanding and therapeutics of hematopoietic diseases-from a viewpoint of regulatory mechanisms of replicative stressPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Takayuki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Gunma University
Regulation of DNA-damage response pathways by the molecular chaperone Hsp90
- Principal Investigator
  
  ODA Tsukasa
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Gunma University
ファンコニ貧血と骨髄異形成症候群におけるゲノム不安定性の分子機構の解明Principal Investigator
- Principal Investigator
  
  山下孝之
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Gunma University
Molecular pathogenesis of Fanconi anemiaPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Takayuki
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Gunma University
ファンコニ貧血と骨髄異形成症候群におけるゲノム不安定性の分子機構の解明Principal Investigator
- Principal Investigator
  
  山下孝之
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
ファンコニ貧血における染色体不安定性と高発癌の分子機構の解明Principal Investigator
- Principal Investigator
  
  山下孝之
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Study of molecular pathogenesis of Fanconi anemiaPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Takayuki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
Fanconi貧血における染色体不安定性と高発癌の分子機構の解析Principal Investigator
- Principal Investigator
  
  山下孝之
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Clarification of molecular mechanisms of chromosome instability and cancer susceptibility in Fanconi anemiaPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Yakayuki
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokyo
Studies on the molecular mechanisms of chromosome instability and development of MDS/AMLPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Takayuki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
造血器腫瘍疾患の発生・悪性化におけるゲノム不安定性の機構の解明Principal Investigator
- Principal Investigator
  
  山下孝之
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
Study of mechanisms of genomic instability in myeloid neoplasm and its therapeutic applicationPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Tasutoshi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
Fanconi貧血における高発癌性の機構の解明Principal Investigator
- Principal Investigator
  
  山下孝之
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
AML/MDSおよび再生不良性貧血発症の遺伝的背景の解明-Fanconi貧血遺伝子FACからのアプローチPrincipal Investigator
- Principal Investigator
  
  山下孝之
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
アクチビン/EDFの造血組織における作用および産生機構Principal Investigator
- Principal Investigator
  
  山下孝之
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
新しい造血因子EDFの作用および産生機構Principal Investigator
- Principal Investigator
  
  山下孝之
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
新しい白血病細胞分化因子アクチビンA/EDFの作用および産生機構Principal Investigator
- Principal Investigator
  
  山下孝之
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo
アクチビンAによる白血病細胞の分化誘導機構Principal Investigator
- Principal Investigator
  
  山下孝之
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo
細胞の癌化におけるCキナーゼと癌遺伝子の相互作用
- Principal Investigator
  
  高井義美
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kobe University
シナプスの可塑性におけるCキナーゼの役割
- Principal Investigator
  
  高井義美
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Kobe University
情報伝達系不全による病態に関する研究
- Principal Investigator
  
  尾形悦郎
- Project Period (FY)
  1987 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  内分泌・代謝学
- Research Institution
  The University of Tokyo
神経伝達物質によるイノシトールリン脂質代謝の抑制機構
- Principal Investigator
  
  高井義美
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kobe University
Phosphoinositide metabolism in transmembrane signalling
- Principal Investigator
  
  TAKAI Yoshimi
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  物質生物化学
- Research Institution
  Kobe University
細胞の癌化におけるCキナーゼと癌遺伝子の相互作用
- Principal Investigator
  
  TAKAI Yoshimi
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kobe University
神経活性物質受容体によるジグリセリド産生の制御機構
- Principal Investigator
  
  高井義美
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Kobe University
血管平滑筋細胞の細胞膜受容伝達機構を構成する蛋白質の同定とその機能の解析
- Principal Investigator
  
  高井義美
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Kobe University
Mechanisms of signaling from cell surface receptors to nuclear genes.
- Principal Investigator
  
  TAKAI Yoshimi
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  物質生物化学
- Research Institution
  Kobe University

[Book] Annual Review血液(分担執筆)II-3 Fanconi貧血の分子病態2011
- Author(s)
  山下孝之
- Total Pages
  5
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-20591109
[Book] Molecular Mechanisms of Fanconi Anemia2006
- Author(s)
  Yamashita T, et al.
- Total Pages
  121
- Publisher
  Landes Bioscience/Eurekah.com
- Data Source
  KAKENHI-PROJECT-16590928
[Book] Molecular Mechanisms of Fanconi Anemia2006
- Author(s)
  Yamashita T, et a1.
- Total Pages
  121
- Publisher
  Landes Bioscience/ Eurekah. com
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590928
[Book] Annual Review血液2011(Fanconi貧血の分子病態)
- Author(s)
  山下孝之
- Data Source
  KAKENHI-PROJECT-20591109
[Journal Article] SMARCA4 deficiency-associated heterochromatin induces intrinsic DNA replication stress and susceptibility to ATR inhibition in lung adenocarcinoma2020
- Author(s)
  Kurashima K, Kashiwagi H, Shimomura I, Suzuki A, Takeshita F, Mazevet M, Harata M Yamashita T, Yamamoto Y, Kohno T, Shiotani B
- Journal Title
  
  NAR Cancer
  
  Volume: 2 Issue: 2 Pages: 1-19
- DOI
  10.1093/narcan/zcaa005
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07772, KAKENHI-PROJECT-20K21261, KAKENHI-PROJECT-19K20456, KAKENHI-PROJECT-18KK0235, KAKENHI-PUBLICLY-20H05378, KAKENHI-PROJECT-18H02164, KAKENHI-PROJECT-18H03378
[Journal Article] SMARCA4 deficiency-associated heterochromatin induces intrinsic DNA replication stress and susceptibility to ATR inhibition in lung adenocarcinoma2020
- Author(s)
  Kurashima K, Kashiwahi H, Shimomura I, Suzuki A, Takeshita F, Mazevet M, Yamashita T, Yamamoto Y, Kohno T, Shiotani B
- Journal Title
  
  NAR cancer
  
  Volume: 2 Pages: 1-19
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07772
[Journal Article] Acute HSF1 depletion induces cellular senescence through the MDM2-p53-p21 pathway in human diploid fibroblasts.2018
- Author(s)
  Oda T, Sekimoto T, Kurashima K, Fujimoto M, Nakai A, Yamashita T.
- Journal Title
  
  Journal of Cell Science
  
  Volume: 印刷中 Issue: 9
- DOI
  10.1242/jcs.210724
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06826, KAKENHI-PROJECT-15K06866, KAKENHI-PROJECT-18K07289, KAKENHI-PROJECT-16K07256, KAKENHI-PROJECT-18H02625
[Journal Article] Both high-fidelity replicative and low-fidelity Y-family polymerases are involved in DNA rereplication.2015
- Author(s)
  Sekimoto T, Oda T, Kurashima K, Hanaoka F, Yamashita T
- Journal Title
  
  Mol Cell Biol
  
  Volume: 35 Issue: 4 Pages: 699-715
- DOI
  10.1128/mcb.01153-14
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-22131008, KAKENHI-PROJECT-24700952, KAKENHI-PUBLICLY-25131703
[Journal Article] Translesion DNA synthesis and Hsp902012
- Author(s)
  Takayuki Yamashita
- Journal Title
  
  Genes and Environment
  
  Volume: 34 Pages: 89-93
- NAID
  10030311653
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501257
[Journal Article] Translesion DNA synthesis and Hsp902012
- Author(s)
  Takayuki Yamashita
- Journal Title
  
  Genes and Environment
  
  Volume: 34 Pages: 89-93
- NAID
  10030311653
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23131503
[Journal Article] Matched sibling donor stem cell transplantation for Fanconi anemia patients with T-cell somatic mosaicism2012
- Author(s)
  Yabe M, Shimizu T, Morimoto T, Koike T, Takakura H, Tsukamoto H, Muroi K, Oshima K, Asami K, Takata M, Yamashita T, Kato S, Yabe H
- Journal Title
  
  Pediatric Transplant
  
  Volume: (印刷中) Issue: 4 Pages: 340-345
- DOI
  10.1111/j.1399-3046.2012.01669.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591262, KAKENHI-PROJECT-22390213, KAKENHI-PROJECT-23501257, KAKENHI-PROJECT-23651046, KAKENHI-PROJECT-24310042, KAKENHI-PLANNED-23114010, KAKENHI-PUBLICLY-23131503
[Journal Article] Translesion DNA synthesis and hsp902012
- Author(s)
  Yamashita T, Oda T, Sekimoto T
- Journal Title
  
  Genes and Environment
  
  Volume: 34 Pages: 89-93
- NAID
  10030311653
- URL
  https://www.jstage.jst.go.jp/article/jemsge/34/2/34_GE-2012-0006/_article
- Data Source
  KAKENHI-PROJECT-23501257
[Journal Article] Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL112011
- Author(s)
  Sasaki M, Kawahara K, Nishio M, Mimori K, Kogo R, Hamada K, Itoh B, Wang J, Komatsu Y, Yang YR, Hikasa H, Horie Y, Yamashita T, Kamijo T, Zhang Y, Zhu Y, Prives C, Nakano T, Mak TW, Sasaki T, Maehama T, Mori M, Suzuki A
- Journal Title
  
  Nat Med
  
  Volume: 17 Issue: 8 Pages: 944-951
- DOI
  10.1038/nm.2392
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501257, KAKENHI-PROJECT-23592132, KAKENHI-PROJECT-23657095
[Journal Article] Molecular chaperone Hsp90 regulates REV1-mediated mutagenesis.2011
- Author(s)
  Pozo FM
- Journal Title
  
  Mol Cell Biol
  
  Volume: 31 Issue: 16 Pages: 3396-3409
- DOI
  10.1128/mcb.05117-11
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22131001, KAKENHI-PLANNED-22131008, KAKENHI-PROJECT-22590264, KAKENHI-PROJECT-22790306, KAKENHI-PUBLICLY-23131503, KAKENHI-PROJECT-23501257, KAKENHI-PROJECT-22249005
[Journal Article] Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL112011
- Author(s)
  Sasaki M, Yamashita T, et al
- Journal Title
  
  Nature Med
  
  Volume: 17 Pages: 944-951
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23131503
[Journal Article] Direct Inhibition of TNF-α Promoter Activity by Fanconi Anemia Prote in FANCD22011
- Author(s)
  Nobuko Matsushita, Yujiro Endo, Koichi Sato, Hitoshi Kurumizaka, Takayuki Yamashita, Minoru Takata, Shigeru Yanagi
- Journal Title
  
  PLoS One
  
  Volume: 6(電子媒体による発表) Issue: 8 Pages: e23324-e23324
- DOI
  10.1371/journal.pone.0023324
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J02700, KAKENHI-PROJECT-21390094, KAKENHI-PROJECT-21590345, KAKENHI-PROJECT-22310119, KAKENHI-PLANNED-23114010, KAKENHI-PUBLICLY-23131503, KAKENHI-PROJECT-23501257, KAKENHI-PROJECT-23650195, KAKENHI-PROJECT-23651046
[Journal Article] Molecular Chaperone Hsp90 Regulates REV1-Mediated Mutagenesis2011
- Author(s)
  Mayca Pozo, F., Oda, T., Sekimoto, T., Murakumo, Y., Masutani, C., Hanaoka, F., Yamashita, T.
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 16 Pages: 3396-3409
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590264
[Journal Article] Molecular chaperone Hsp90 regulates REV1-mediated mutagenesis2011
- Author(s)
  Pozo FM, Oda T, Sekimoto T, Murakumo Y, Masutani C, Hanaoka F, Yamashita T
- Journal Title
  
  Mol Cell Biol
  
  Volume: 31 Pages: 3396-3409
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501257
[Journal Article] The Molecular Chaperone Hsp90 Regulates Accumulation of DNA Polymerase η at Replication Stalling Sites in UV-irradiated Cells.2010
- Author(s)
  Sekimoto T, Oda T, Yamashita T., et al.
- Journal Title
  
  Mol Cell 37
  
  Pages: 79-89
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591109
[Journal Article] The molecular chaperone Hsp90 regulates accumulation of DNA polymerase eta at replication stalling sites in UV-irradiated cells2010
- Author(s)
  Sekimoto T, Yamashita T, et al.
- Journal Title
  
  Molecular Cell
  
  Volume: 37 Pages: 79-89
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591109
[Journal Article] The Molecular chaperone Hsp90 regulates accumulation of DNA polymerase η at replication stalling sites in UV-irradiated cells2010
- Author(s)
  Sekimoto T, Yamashita T, et al.
- Journal Title
  
  Molecular Cell 37
  
  Pages: 79-89
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591109
[Journal Article] Fanconi貧血2009
- Author(s)
  山下孝之、小田司、関本隆志
- Journal Title
  
  臨床血液 50(印刷中)
- NAID
  130007659587
- Data Source
  KAKENHI-PROJECT-20591109
[Journal Article] Fanconi貧血の分子病態2009
- Author(s)
  山下孝之
- Journal Title
  
  分子細胞治療 8
  
  Pages: 89-92
- Data Source
  KAKENHI-PROJECT-20591109
[Journal Article] Fanconi貧血の分子病態-最近の進歩2009
- Author(s)
  山下孝之、小田司、関本隆本
- Journal Title
  
  臨床血液 50
  
  Pages: 538-546
- NAID
  130004501341
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591109
[Journal Article] Correction of mutant Fanconi anemia gene by homologous recombination in human hematopoietic cells using adenoassociated virus vector.2009
- Author(s)
  Paiboonsukwong K, Yamashita T, et al.
- Journal Title
  
  J.Gene Med. 11
  
  Pages: 1012-1019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591109
[Journal Article] Fanconi貧血-ゲノム損傷ストレスと造血幹細胞の老化2008
- Author(s)
  山下孝之、小田司、関本隆志(3人中)
- Journal Title
  
  二本臨床 66
  
  Pages: 477-482
- Data Source
  KAKENHI-PROJECT-19590270
[Journal Article] Fanconi貧血-ゲノム損傷ストレスと造血幹細胞の老化-2008
- Author(s)
  山下孝之
- Journal Title
  
  日本臨床 66
  
  Pages: 477-482
- Data Source
  KAKENHI-PROJECT-19590270
[Journal Article] Fanconi貧血-ゲノム損傷ストレスと造血幹細胞の老化-2008
- Author(s)
  山下孝之、小田司、関本隆志
- Journal Title
  
  日本臨床 66
  
  Pages: 477-482
- Data Source
  KAKENHI-PROJECT-20591109
[Journal Article] Hsp90 regulates the Fanconi anemia DNA damage response pathway2007
- Author(s)
  Oda T, Hayano T, Yamashita T.(他2人)
- Journal Title
  
  Blood 109
  
  Pages: 5016-5026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590270
[Journal Article] Hsp90 and the Fanconi anemia pathway:a molecular link between protein quality control and the DNA damage response2007
- Author(s)
  山下孝之
- Journal Title
  
  Cell Cycle 6
  
  Pages: 2232-2235
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590270
[Journal Article] A requirement of FancL and FancD2 monoubiquitination in DNA repair2007
- Author(s)
  Seki S, Oda T, Yamashita T.(他9人)
- Journal Title
  
  Gene to Cells 12
  
  Pages: 299-310
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590270
[Journal Article] Hsp90 and the Fanconi anemia pathway : a molecular link between protein quality control and the DNA damage response2007
- Author(s)
  Yamashita T, Oda T, Sekimoto T.(3人中)
- Journal Title
  
  Cell Cycle 15
  
  Pages: 2232-2235
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590270
[Journal Article] Myeloid lineage-selective growth of revertant cells in Fanconi anemia.2006
- Author(s)
  Hamanoue S, Oda T, Yamashita T et al.
- Journal Title
  
  British Journal of Haematology 132
  
  Pages: 630-635
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590928
[Journal Article] ABT1-associated protein (ABTAP), a novel nuclear protein conserved from yeast to mammals, represses transcriptional activation by ABT1.2004
- Author(s)
  Oda T, Yamashita T, et al.
- Journal Title
  
  Journal of Cellular Biochemistry 93
  
  Pages: 788-806
- Data Source
  KAKENHI-PROJECT-16590928
[Journal Article] ABT1-associated protein(ABTAP), a novel nuclear protein conserved from yeast to mammals, represses transcriptional activation by ABT1.2004
- Author(s)
  Oda T, Yamashita T, et al.
- Journal Title
  
  Journal of Cellular Biochemistry 93
  
  Pages: 788-806
- Data Source
  KAKENHI-PROJECT-16021213
[Journal Article] Identification and charactreization of the major Fanconi anemia gene FANCA in the Japanese population.2004
- Author(s)
  Yagasaki H, Yamashita T, et al.
- Journal Title
  
  Human Mutation 24
  
  Pages: 481-490
- Data Source
  KAKENHI-PROJECT-16021213
[Journal Article] Identification and characterization of the major Fanconi anemia gene FANCA in the Japanese population.2004
- Author(s)
  Yagasaki H, Yamashita T, et al.
- Journal Title
  
  Human Mutation 24
  
  Pages: 481-490
- Data Source
  KAKENHI-PROJECT-16590928
[Presentation] G-quadruplex in Myc-induced replication stress; as a potential therapeutic target2020
- Author(s)
  Sekimoto T, Yamashita T
- Organizer
  第４３回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-19K07772
[Presentation] がん遺伝子誘導性複製ストレスにおけるグアニン四重鎖構造DNAの役割2019
- Author(s)
  関本　隆志、山下孝之
- Organizer
  第４２回　日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07772
[Presentation] SMRCA4欠損は内在性DNA複製ストレスの増加とreversed forkの不安定化を誘導しATR阻害剤感受性を高める2019
- Author(s)
  倉島公憲、柏木秀人、山下孝之、河野隆志、塩谷文章
- Organizer
  第４２回　日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07772
[Presentation] MDM2阻害因子Dehydrogenase/reductgase 2 (DHRS2)の細胞老化における役割2017
- Author(s)
  小田司、関本隆志、倉島公憲、中村瑠里、松田美弥子、大圃真澄、山下孝之
- Organizer
  第40回分子生物学会年会
- Data Source
  KAKENHI-PROJECT-15K06825
[Presentation] DNA架橋剤メルファランは多発性骨髄腫細胞株において主要組織適合抗原クラスII (MHC II)の転写活性化因子CIITAの発現を促進する2017
- Author(s)
  中村瑠里、小田司、関本隆志、松田美弥子、大圃真純、半田寛、笠松哲光、齋藤貴之、村上博和、山下孝之
- Organizer
  第40回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-15K06866
[Presentation] HSF1抑制はDHRS2-MDM2-p53経路を介してヒト線維芽細胞に老化を誘導する2017
- Author(s)
  小田司、関本隆志、倉島公憲、山下孝之
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-15K06825
[Presentation] Y-familyポリメラーゼPolηはMus81/EME2ヌクレアーゼ複合体と協同してがん遺伝子c-Mycによるreplication stress (RS)を緩和する2017
- Author(s)
  関本隆志、倉島公憲、小田司、川端剛、松田美弥子、中村瑠里、大圃真澄、花岡文雄、山下孝之
- Organizer
  第40回分子生物学会年会
- Data Source
  KAKENHI-PROJECT-15K06825
[Presentation] Y-familyポリメラーゼPolηはMus81/EME2ヌクレアーゼ複合体と協同してがん遺伝子c-Mycによるreplication stress (RS)を緩和する2017
- Author(s)
  関本隆志、倉島公憲、小田司、川端剛、松田美弥子、中村瑠里、大圃真純、花岡文雄、山下孝之
- Organizer
  第40回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-15K06866
[Presentation] HSF1 depletion induces senescence through DHRS2-MDM2-p53 pathway in immortalized human diploid fibroblasts (iHDFs)2017
- Author(s)
  Tsukasa Oda, Takayuki Sekimoto, Kiminori Kurashima, Takayuki Yamashita
- Organizer
  76 th Annual Meeting of the Japanese Cancer Association
- Data Source
  KAKENHI-PROJECT-15K06866
[Presentation] DNA架橋剤メルファランは多発性骨髄腫細胞株において主要組織適合抗原クラスII(MHC II)の転写活性化因子CIITAの発現を促進する2017
- Author(s)
  中村瑠里、小田司、関本隆志、松田美弥子、大圃真澄、半田寛、笠松哲光、斎藤貴之、村上博和、山下孝之
- Organizer
  第40回分子生物学会年会
- Data Source
  KAKENHI-PROJECT-15K06825
[Presentation] Myc誘導性複製ストレス応答においてPolηとMUS81-EME2の二重阻害は合成致死を示す2017
- Author(s)
  倉島公憲、関本隆志、小田司、花岡文雄、山下孝之
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-15K06825
[Presentation] Apurinic/apyrimidinic endonuclease 1 is involved in the pathogenesis of acute myeloid leukemia2017
- Author(s)
  Yuya Kitamura, Takayuki Saitoh, Noriyuki Takahashi, Rumi Ino, Nanami Gotoh, Akihiko Yokohama, Tsukasa Oda, Takayuki Yamashita, Norifumi Tsukamoto, Hiroshi Handa, Hirokazu Murakami
- Organizer
  The 79th Annual Meeting of the Japanese Society of Hematology
- Data Source
  KAKENHI-PROJECT-15K06866
[Presentation] Synthetic lethal interaction between Polη and MUS81-EME2 in cellular response to Myc-induced replication stress2017
- Author(s)
  倉島公憲、関本隆志、小田司、花岡文雄、山下孝之
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-15K06826
[Presentation] Synthetic lethal interactions between Polη and MUS81-EME2 in cellular response to Myc-induced replication stress (RS)2017
- Author(s)
  Kiminori Kurashima, Takayuki Sekimoto, Tsukasa Oda, Fumio Hanaoka, Takayuki Yamashita
- Organizer
  76 th Annual Meeting of the Japanese Cancer Association
- Data Source
  KAKENHI-PROJECT-15K06866
[Presentation] HSF1 depletion induces senescence through DHRS2-MDM2-p53 pathway in immortalized human fibroblasts2017
- Author(s)
  小田司、関本隆志、倉島公憲、山下孝之
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-15K06826
[Presentation] DNA架橋剤メルファランは多発性骨髄腫細胞株において主要組織適合抗原クラスII(MHC II)の転写活性化因子CIITAの発現を促進する2017
- Author(s)
  中村瑠里、小田司、関本隆志、松田美弥子、大圃真澄、半田寛、笠松哲光、斎藤貴之、村上博和、山下孝之
- Organizer
  第40回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-15K06826
[Presentation] Y-familyポリメラーゼPolηはMus81/EME2ヌクレアーゼ複合体と協同してがん遺伝子c-Mycによるreplication stressを緩和する2017
- Author(s)
  関本隆志、倉島公憲、小田司、川端剛、松田美弥子、中村瑠里、大圃真澄、花岡文雄、山下孝之
- Organizer
  第40回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-15K06826
[Presentation] MDM2阻害因子Dehydrogenase/reductgase 2 (DHRS2)の細胞老化における役割2017
- Author(s)
  小田司、関本隆志、倉島公憲、中村瑠里、松田美弥子、大圃真澄、山下孝之
- Organizer
  第40回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-15K06826
[Presentation] Polη, a Y-family tranlesion synthesis (TLS) polymerase, mitigates c-Myc induced replication stress2016
- Author(s)
  倉島公憲、関本隆志、小田司、花岡文雄、山下孝之
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K06825
[Presentation] HSF1 depletion induces cellular senescence independently of proteotoxic stress in immortalized human diploid fibroblasts (iHDFs)2016
- Author(s)
  Tsukasa Oda, Takayuki Sekimoto, Kiminori Kurashima, Takayuki Yamashita
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K06866
[Presentation] Polη, a Y-family translesion synthesis (TLS) polymerase, mitigates c-MYC induced replication stress2016
- Author(s)
  K Kurashima, T Sekimoto, T Oda, F Hanaoka, T Yamashita
- Organizer
  第７６回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K06826
[Presentation] Y-familyポリメラーゼPolηとエンドヌクレアーゼMus81-Eme2複合体は段階的に協調してc-MYCがん遺伝子誘導性複製ストレスを抑制する2016
- Author(s)
  倉島公憲、関本隆志、小田司、花岡文雄、山下孝之
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K06825
[Presentation] Y-familyポリメラーゼPolηとエンドヌクレアーゼ複合体Mus81-Eme2複合体は段階的に協調してc-MYCがん遺伝子誘導性複製ストレスを抑制する2016
- Author(s)
  倉島公憲、関本隆志、小田司、川端剛,、花岡文雄、山下孝之
- Organizer
  第３９回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K06826
[Presentation] 熱ショック応答転写因子Heat shock factor 1 (HSF1)の発現抑制による細胞老化はMDM2阻害蛋白Dehydrogenase/reductase 2 (DHRS2)に制御されている可能性がある2016
- Author(s)
  小田　司、関本隆志、倉島公憲、山下孝之
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K06866
[Presentation] 熱ショック応答転写因子Heat shock factor 1 (HSF1)の発現抑制による細胞老化はMDM2阻害蛋白Dehydrogenase/reductase 2 (DHRS2)に制御されている可能性がある2016
- Author(s)
  小田司、関本隆志、倉島公憲、山下孝之
- Organizer
  第３９回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K06826
[Presentation] HSF1 depletion induces cellular senescence independently of proteotoxic stress in immortalized human diploid fibroblasts2016
- Author(s)
  T Oda, T Sekimoto, K Kurashima, T Yamashita
- Organizer
  第７６回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K06826
[Presentation] 熱ショック応答転写因子Heat shock factor 1 （HSF1）の発現抑制による細胞老化はMDM2阻害蛋白Dehydrogenase/reductase2（DHRS2）に制御されている可能性がある2016
- Author(s)
  小田司、関本隆志、倉島公憲、山下孝之
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K06825
[Presentation] HSF1 depletion induces cellular senescence independently of proteotoxic stress2016
- Author(s)
  小田司、関本隆志、倉島公憲、山下孝之
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K06825
[Presentation] Heat shock factor 1 (HSF1)はDNA損傷および蛋白変性ストレスと独立して細胞老化を誘導する2015
- Author(s)
  小田司、関本隆志、倉島公憲、山下孝之
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸ポートピアランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K06866
[Presentation] Y-family損傷乗り越えDNAポリメラーゼ(Y-Pol)の一員PolηはMYCがん遺伝子の誘導する複製ストレスを軽減する2015
- Author(s)
  倉島公憲、関本隆志、小田司、川端剛、花岡文雄、山下孝之
- Organizer
  第３８回　日本分子生物学会年会
- Place of Presentation
  神戸国際会議場（兵庫県・神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K06826
[Presentation] Y-family損傷乗り越えDNAポリメラーゼ(Y-Pol)の一員PolηはMYCがん遺伝子の誘導する複製ストレスを軽減する2015
- Author(s)
  倉島公憲、関本隆志、小田司、川端剛、花岡文雄、山下孝之
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸ポートピアランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K06825
[Presentation] Heat shock factor 1 (HSF1)抑制はDNA損傷および蛋白変性ストレスと独立して細胞老化を誘導する2015
- Author(s)
  小田司、関本隆志、倉島公憲、山下孝之
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸ポートピアランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K06825
[Presentation] Polη, a member of Y-family DNA polymerases, prevents generation of DNA double strand breaks induced by c-myc expression2015
- Author(s)
  倉島公憲、関本隆志、小田司、花岡文雄、山下孝之
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K06866
[Presentation] Y-family損傷乗り越えDNAポリメラーゼ(Y-Pol)の一員PolηはMYCがん遺伝子の誘導する複製ストレスを軽減する2015
- Author(s)
  倉島公憲、関本隆志、小田司、川端剛、花岡文雄、山下孝之
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸ポートピアランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K06866
[Presentation] Polη, a member of Y-family DNA polymerases, prevents generation of DNA double strand breaks induced by c-myc expression2015
- Author(s)
  倉島公憲、関本隆志、小田司、花岡文雄、山下孝之
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K06825
[Presentation] Acute inhibition of heat shock factor 1 (HSF1) induces cellular senescence through cell type dependent mechanisms2015
- Author(s)
  小田司、関本隆志、倉島公憲、山下孝之
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K06866
[Presentation] Acute inhibition of heat shock factor 1 (HSF1) induces cellular senescence through cell type-dependent mechanisms2015
- Author(s)
  小田司、関本隆志、倉島公憲、山下孝之
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K06825
[Presentation] Polη, a member of Y-family DNA polymerases, prevents generation of DNA double strand breaks induced by c-myc expression2015
- Author(s)
  Kiminori Kurashima, Takayuki Sekimoto, Tsukasa Oda, Fumio Hanaoka, Takayuki Yamashita
- Organizer
  第７５回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛媛県・名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K06826
[Presentation] DNA polymerase-eta promotes DNA rereplication2014
- Author(s)
  山下孝之
- Organizer
  International symposium on xeroderma pigmentosum and related disorders
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23501257
[Presentation] DNA polymerase η promotes DNA rereplication2014
- Author(s)
  山下孝之
- Organizer
  International symposium on xeroderma pigmentosum and related disorders
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23501257
[Presentation] DNA polymerase η promotes DNA rereplication2014
- Author(s)
  山下孝之
- Organizer
  International symposium on xeroderma pigmentosum and related disorders
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PUBLICLY-25131703
[Presentation] Polymerase η は発がん遺伝子が誘導するDNA再複製に関与する2013
- Author(s)
  関本隆志、小田司、益谷央豪、山下孝之
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23501257
[Presentation] DHRS2は熱ショック転写因子HSF1 抑制で誘導される細胞老化に関与する可能性がある2013
- Author(s)
  小田司、関本隆志、山下孝之
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23501257
[Presentation] Polymerase η は発がん遺伝子が誘導するDNA再複製に関与する2013
- Author(s)
  関本隆志、小田司、益谷央豪、花岡文雄、山下孝之
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PUBLICLY-25131703
[Presentation] Polymerase-eta は発がん遺伝子が誘導するDNA 再複製に関与する2013
- Author(s)
  関本隆志、小田司、花岡文雄、山下孝之
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23501257
[Presentation] Y-familyポリメラーゼは発がんシグナルが誘導するDNA再複製に関与する2013
- Author(s)
  関本隆志、小田司、益谷央豪、花岡文雄、山下孝之
- Organizer
  第72回日本癌学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23501257
[Presentation] Y-family DNA ポリメラーゼは、発がんシグナルが誘導するDNA 再複製に関与する2013
- Author(s)
  関本隆志、小田司、益谷央豪、花岡文雄、山下孝之
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23501257
[Presentation] DHRS2は熱ショック転写因子HSF1抑制で誘導される細胞老化に関与する2013
- Author(s)
  小田司、関本隆志、山下孝之
- Organizer
  第72回日本癌学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PUBLICLY-25131703
[Presentation] DHRS2は熱ショック転写因子HSF1抑制で誘導される細胞老化に関与する2013
- Author(s)
  小田司、関本隆志、山下孝之
- Organizer
  第72回日本癌学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23501257
[Presentation] DHRS2は熱ショック転写因子HSF1抑制で誘導される細胞老化に関与する可能性がある2013
- Author(s)
  小田司、関本隆志、山下孝之
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PUBLICLY-25131703
[Presentation] Y-familyポリメラーゼは発がんシグナルが誘導するDNA再複製に関与する2013
- Author(s)
  関本隆志、小田司、益谷央豪、花岡文雄、山下孝之
- Organizer
  第72回日本癌学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PUBLICLY-25131703
[Presentation] DHRS2は、熱ショック転写因子HSF1の発現抑制で誘導される細胞老化に関与する可能性がある2013
- Author(s)
  小田　司、関本隆志、山下孝之
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23501257
[Presentation] Polymerase-eta is involved in oncogene-induced DNA re-replication and DNA damage responses2012
- Author(s)
  関本隆志、小田司、益谷央豪、花岡文雄、山下孝之
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23501257
[Presentation] Y-family DNAポリメラーゼは、発がんシグナルが誘導するDNA再複製に関与する2012
- Author(s)
  関本隆志、小田司、益谷央豪、花岡文雄、山下孝之
- Organizer
  第35回日本分子生物学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22590264
[Presentation] 熱ショック応答転写因子Heat shock factor 1(HSF1)の抑制による細胞老化の誘導機構:DHRS2とp300/CBPの関与2012
- Author(s)
  小田司、関本隆志、山下孝之
- Organizer
  第35回日本分子生物学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22590264
[Presentation] 熱ショック応答転写因子Heat shock factor 1 (HSF1)の抑制によるp53 依存性細胞老化にはDHRS2 の発現誘導が重要である2012
- Author(s)
  小田司、関本隆志、山下孝之
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23501257
[Presentation] Y-family DNA ポリメラーゼは、発がんシグナルが誘導するDNA 再複製に関与する2012
- Author(s)
  関本隆志、小田司、益谷央豪、花岡文雄、山下孝之
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23501257
[Presentation] ポリメラーゼηは発がんシグナルが誘導するDNA再複製DNA損傷応答に関与する2012
- Author(s)
  関本隆志、小田司、益谷央豪、花岡文雄、山下孝之
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22590264
[Presentation] Y-family DNAポリメラーゼによる損傷乗り越えDNA合成は、cyclin E過剰発現によるDNA複製ストレス応答に関与する2011
- Author(s)
  関本隆志、山下孝之, ら
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PUBLICLY-23131503
[Presentation] 分子シャペロンHsp90はREV1による突然変異の誘発を制御する2011
- Author(s)
  マイカポゾフランクリン、小田司、関本隆志、村雲芳樹、益谷央豪、花岡文雄、山下孝之
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22590264
[Presentation] 分子シャペロンHsp90 はREV1 による突然変異の誘発を制御する2011
- Author(s)
  マイカポゾフランクリン、小田司、関本隆志、村雲芳樹、益谷央豪、花岡文雄、山下孝之
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23501257
[Presentation] Y-family DNAポリメラーゼによる損傷乗り越えDNA合成は、cyclinE過剰発現によるDNA複製ストレス応答に関与する2011
- Author(s)
  関本隆志、小田司、益谷央豪、花岡文雄、山下孝之
- Organizer
  第34回日本分子生物学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22590264
[Presentation] 熱ショック転写因子HSF1の急性欠乏は複数の腫瘍抑制経路を介して細胞老化プログラムを活性化する2011
- Author(s)
  小田司、関本隆志、山下孝之
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22590264
[Presentation] 熱ショック応答転写因子Heat shock factor1(HSF1)の発現抑制はp53-p21経路を介した細胞老化を誘導する2011
- Author(s)
  小田司、関本隆志、山下孝之
- Organizer
  第34回日本分子生物学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22590264
[Presentation] 熱ショック応答転写因子Heat shock factor 1 (HSF1)の転写活性の抑制はp53-p21 経路を介した細胞老化を誘導する2011
- Author(s)
  小田司、関本隆志、山下孝之
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23501257
[Presentation] Y-family DNA ポリメラーゼによる損傷乗り越えDNA 合成は、cyclin E過剰発現によるDNA 複製ストレス応答に関与する2011
- Author(s)
  関本隆志、小田司、益谷央豪、花岡文雄、山下孝之
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23501257
[Presentation] Acute depletion of Heat shock factor (HSF) 1 triggers cell senescence program by activating multiple tumor suppressor pathways.2010
- Author(s)
  小田司、山下孝之, ら
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-20591109
[Presentation] Acute depletion of Heat shock factor (HSF) 1 activates tumor-suppressive cell senescence program.2010
- Author(s)
  小田司, 関本隆志, 山下孝之
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-20591109
[Presentation] The"cancer chaperone"Hsp90 promotes DNA polymarase-eta-mediated translesion synthesis2010
- Author(s)
  山下孝之
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-20591109
[Presentation] 「がんシャペロン」Hsp90はDNAポリメラーゼ-&etaによる損傷乗り越えDNA合成を促進する2010
- Author(s)
  山下孝之
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪(招待講演)
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-20591109
[Presentation] 熱ショック転写因子HSF1 の急性欠乏は複数の腫瘍抑制経路を介して細胞老化プログラムを活性化する2010
- Author(s)
  小田司、関本隆志、山下孝之
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23501257
[Presentation] 熱ショック転写因子HSF1の急性欠乏は腫瘍抑制性の細胞老化プログラムを活性化する2010
- Author(s)
  小田司、関本隆志、山下孝之
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22590264
[Presentation] 熱ショック応答転写因子Heat shock factor 1の発現抑制はhTERT不死化ヒト細胞においてp53-p21を介する細胞老化を引き起こす2009
- Author(s)
  小田司、関本隆志、山下孝之,ら
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-20591109
[Presentation] 分子シャペロンHsp90はY-family DNAポリメラーゼREV1のDNA損傷による核内フォーカス形成を促進する2009
- Author(s)
  Mayca Pozo Franklin, 小田司、関本隆志、山下孝之,ら
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PROJECT-20591109
[Presentation] 分子シャペロンHsp90はY-family DNA Polymerase REV1のDNA損傷による核内フォーカス形成を促進する2009
- Author(s)
  Franklin Mayca Pozo、山下孝之, ら
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-20591109
[Presentation] 熱ショック応答転写因子Heat shock factor 1(HSF1)の発現抑制はhTERT不死化ヒト細胞においてp53-p21を介する細胞老化を引き起こす2009
- Author(s)
  小田司、山下孝之, ら
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-20591109
[Presentation] Fanconi貧血の分子病態-最近の進歩2008
- Author(s)
  山下孝之、小田司、関本隆志
- Organizer
  第70回日本血液学会総会
- Place of Presentation
  京都
- Year and Date
  2008-10-11
- Data Source
  KAKENHI-PROJECT-20591109
[Presentation] Fanconi貧血の分子病態-最近の進歩2008
- Author(s)
  山下孝之、小田司、関本隆志
- Organizer
  第70回日本血液学会総会
- Place of Presentation
  京都(招待講演)
- Year and Date
  2008-10-11
- Data Source
  KAKENHI-PROJECT-20591109
[Presentation] 分子シャペロンHSP90はPolymerase-η(Pol-η〉の複製フォーカスへの集積と損傷乗越えDNA合成(TLS)を促進するえDNA合成(TLS)を促進する2008
- Author(s)
  関本隆志、小田司、フランクリンマイカポゾ、村雲芳樹、益谷来豪、花岡文雄、山下孝之
- Organizer
  第31回日本分子生物学会年会第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-20591109
[Presentation] 分子シャペロンHSP90はPolymerase-η(Pol-η)の複製フォーカスへの集積と損傷乗越えDNA合成(TLS)を促進する2008
- Author(s)
  関本隆志、小田司、山下孝之,ら
- Organizer
  第31回日本分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-20591109
[Presentation] Inhibition of Heat Shock Factor 1 (HSF1) selectively activates cellular senescence program in Ras V12-transformed cells
- Author(s)
  小田　司、関本隆志、倉島公憲、山下孝之
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PUBLICLY-25131703
[Presentation] Y-family polymerases are involved in oncogene-induced aberrant replication
- Author(s)
  山下孝之
- Organizer
  5th US-Japan DNA Repair Meeting
- Place of Presentation
  鳴門、徳島
- Year and Date
  2014-10-28 – 2014-10-31
- Data Source
  KAKENHI-PUBLICLY-25131703
[Presentation] DNA polymerase η (Polη) suppresses c-myc-induced replication stress
- Author(s)
  倉島公憲、倉島公憲、関本隆志、花岡文雄、山下孝之
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PUBLICLY-25131703
[Presentation] Y-family DNAポリメラーゼによる損傷乗り越えDNA合成は、cyclin E過剰発現によるDNA複製ストレス応答に関与する
- Author(s)
  関本隆志、山下孝之ら
- Organizer
  第３４回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23501257

1. ODA Tsukasa (10323643)

# of Collaborated Projects: 12 results

# of Collaborated Products: 81 results
2. TAKAI Yoshimi (60093514)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
3. ASANO Shigetaka (50134614)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
4. NAKAHATA Tasutoshi (20110744)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
5. SEKIMOTO Takayuki (20436322)

# of Collaborated Projects: 5 results

# of Collaborated Products: 57 results
6. KAIBUCHI Kozo (00169377)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
7. KAWAHARA Yasuhiro (80169755)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. 高橋俊二 (90221358)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. KANO Yoshio (70116200)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KIKUCHI Akira (10204827)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 本倉徹 (00192823)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 大江良秀 (80125830)

# of Collaborated Projects: 1 results

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13. 溝口明 (90181916)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 尾形悦郎 (70013761)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 峯徹哉 (20157572)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 小島至 (60143492)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 松本俊夫 (20157374)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 五十嵐徹也 (00134601)

# of Collaborated Projects: 1 results

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19. 岡崎具樹 (60203973)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 西本育夫 (80180652)

# of Collaborated Projects: 1 results

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21. 貴田岡正央 (20153091)

# of Collaborated Projects: 1 results

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22. NAKAI Akira

# of Collaborated Projects: 1 results

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23. FUJIMOTO Mitsuaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 芝井博四郎

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 柴井博四郎

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 内山薫

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. YABE Miharu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. YABE Hiromasa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. KATO Shunichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 花岡文雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YAMASHITA Takayuki 山下 孝之

YAMASHITA Tasutoshi 山下 孝之

Research Projects

Research Products

Co-Researchers

発がんシグナル誘導性複製ストレスへの応答機構を標的とする治療開発Principal Investigator

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The role of Y-family polymerase in aberrant DNA replication and genomic instabilityPrincipal Investigator

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Analysis of oncogene-induced replication stress response patyways

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Molecular basis for the development of anti-tumor therapy by targeting HSF1.

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がん遺伝子が誘導する複製ストレス応答におけるY-familyポリメラーゼの役割Principal Investigator

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発がんシグナルが誘導するＤＮＡ複製異常におけるＹ－ｆａｍｉｌｙポリメラーゼの役割Principal Investigator

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Roles of replication stress for cellular senescence and genome instability in preneoplastic lesionsPrincipal Investigator

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Regulation of the DNA damage response mediated by the heat shock response

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New understanding and therapeutics of hematopoietic diseases-from a viewpoint of regulatory mechanisms of replicative stressPrincipal Investigator

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Regulation of DNA-damage response pathways by the molecular chaperone Hsp90

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ファンコニ貧血と骨髄異形成症候群におけるゲノム不安定性の分子機構の解明Principal Investigator

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Molecular pathogenesis of Fanconi anemiaPrincipal Investigator

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ファンコニ貧血と骨髄異形成症候群におけるゲノム不安定性の分子機構の解明Principal Investigator

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Project Period (FY)

YAMASHITA Takayuki 山下孝之

YAMASHITA Tasutoshi 山下孝之