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Miyata Toshio  宮田 敏男

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MIYATA Toshio  宮田 敏男

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Researcher Number 10222332
Other IDs
Affiliation (Current) 2025: 東北大学, 医学系研究科, 教授
Affiliation (based on the past Project Information) *help 2024: 東北大学, 医学系研究科, 教授
2017: 東北大学, 大学院・医学系研究科, 教授
2014: 東北大学, 医学系, 教授
2012 – 2014: 東北大学, 医学(系)研究科(研究院), 教授
2010: 東北大学, 大学院・医学系・研究科・付属創生応用医学研究センター, センター長(教授) … More
2009: Tohoku University, 大学院・医学系研究科, 教授
2008: 東北大学, 医学部, 教授
2005 – 2007: 東海大学, 医学部, 教授
2005 – 2006: 東海大学, 総合医学研究所, 教授
2002: Tokai University, Medical Research Institute, Associate professor, 総合医学研究所, 助教授
2000 – 2001: Tokai University School of Medicine, Associate Professor, 医学部, 助教授
1999: 東海大学, 総合医学研究所, 助教授
1997 – 1998: Tokai University School of Medicine, Associate Professor, 総合医学研究所, 講師
1994 – 1996: 名古屋大学, 医学部, 講師
1993: 大阪大学, 微生物病研究所, 助手 Less
Review Section/Research Field
Principal Investigator
Kidney internal medicine / Kidney internal medicine / Applied pharmacology / Hematology
Except Principal Investigator
Kidney internal medicine / Kidney internal medicine / Basic Section 55060:Emergency medicine-related / Tumor biology / General medical chemistry / Psychiatric science / Neurology
Keywords
Principal Investigator
HIF / hypoxia / advanced glycation end product / AGEs / カルボニルストレス / diabetic nephropathy / brain protection / renoprotection / prolyl hydroxy lase / chronic hypoxia … More / angiogenesis / structure based drug design / hypoxia inducible factor / 糖尿病性腎症 / 脳保護 / 腎保護 / prolyl hydroxylase / 慢性虚血 / peritoneal dialysis / carbonyl trap bead / glyoxalase / irreversible protein modification / carbonyl stress / reactive carbonvl compound / トランスジェニックマウス / AGE阻害剤 / advanced glycation end products / 腹膜透析 / カルボニルトラップビーズ / グリオキサラーゼ / 蛋白修飾異常 / 反応性カルボニル化合物 / Pentosidine / Diabetes mellitus / Reduction and oxidation / Renal failure / Carbonyl stress / Oxidative stress / ペントシジン / 糖尿病 / レドックス制御 / 腎不全 / 酸化ストレス / serine protease inhibitor (serpin) family / fibronectin / gene expression profile / Glomerular mesangial cells (GMC) / HNC特異的遺伝子 / HMC cDNAライブラリー / セリンプロテアーゼインヒビター / HMC特異的遺伝子 / メサンギウム細胞(HMC) / 生体分子 / 生理活性 / 薬理学 / edaravone / ジメチルマレイン酸 / SBDD / レポーターアッセイ / X線結晶解析情報 / keep1阻害剤 / Nrf2-Keep1相互作用 / 酸化ストレス応答 / Advanced glycation end products / メイラード反応 / β2ミクログロブリン / 透析アミロイドーシス / RT-PCR / 体細胞突然変異 / GPIアンカー型蛋白 / PIG-A / 発作性夜間血色素尿症 … More
Except Principal Investigator
megsin / serpin / mesangial cells / メサンギウム細胞 / 腎不全 / PAI-1 / ARB / mesangial matrix / トランスジェニックマウス / メサンギウム基質 / セルピン / メグシン / transcriptional factor / promoter / ペントシジン / AGE / 低分子化合物 / 酸化ストレス / カルボニルストレス / 造血幹細胞 / 播種性血管内凝固 / 敗血症 / MT1-MMP / 治療抵抗性 / 繊維素溶解系 / 薬剤耐性 / がん幹細胞 / TGF-b / 白血病幹細胞 / TGF-beta / 分子標的薬 / ニッチ / 幹細胞 / 白血病 / pendisidine / pyrazolinones-polyethyleneimine / bead / Pyridoxamine / advanced glycation end products / effective peritoneal surface area / peritoneal Dialysis / トランスジェニックラット / ピリドキサミン / 腹腔透析 / グリオキサラーゼI / TM2002 / エダラボン / グリオキサラーゼ1 / 腹膜機能不全 / 腹膜透析 / 慢性腎不全 / chronic kidney failure / hypoxia / ischemia / 低酸素 / 虚血 / transgenic mice / glomerulonephritis / serine protease / メアンギウム基質 / 糸球体腎炎 / セリンプロテアーゼ / transgenie mice / 転写因子 / mesangioproliferative glomerulonephritis / 特異的DNA結合蛋白 / メサンギウム細胞特異的転写調節機構 / 進行性糸球体障害 / メサンギウム細胞増殖性糸球体腎炎 / 転写調節因子 / molecular biology / mesangioproliferative glomenilonephlitis / mesangium-specific transcription factor / 3'-directed cDNA library / library法 / cDNA / 3'-directed / メサンギウム細胞特異的遺伝子 / 分子生物学 / 進行性糸球体疾患 / スサンギウム細胞特異的遺伝子 / 3'-directed cDNA library法 / gene therapy / adonovirus / vitamin D receptor / vitamin D / PTH / cell prolifiration / parathyroid hyperplasia / parathyroid / アデノウイルススベクター / 核増殖抗原 / 過形成 / カルシウムセンサー, / ビタミンD受容体, / ビタミンD, / 遺伝子治療 / アデノウイルス / ビタミンD受容体 / ビタミンD / 副甲状腺ホルモン / 細胞増殖 / 副甲状腺過形成 / 副甲状腺 / oxidative stress / uraemia / beta2-microglobuli / Advanced glycation end-products / dialysis-related amyloidosis / 抗AGEs抗体 / アマドリ構造 / Advanced Glycation End Products:AGEs / カルボキシルメチルリジン / AGEsレセプター / β2ミクログロブリン / メイラード反応 / カルボキシメチルリジン / AGEs / Redox imbalance / RAGE / β2-ミクログロブリン / 透析アミロイドーシス / 再生医療 / 線維素溶解系 / 再生 / 造血再生 / 遺転子 / 脳・神経 / 遺伝子 / ゲノム / ストレス / ビタミン / グリオキサラーゼ / 遺伝子変異 / 統合失調症 / フリーラジカル / 小胞体ストレス / 脳梗塞 / hypoxia inducible factor / advanced glycation end product / 神経病態薬理学 / 補体 / GPIアンカー / 糖鎖遺伝子 / 遺伝子病 / X染色体 / 体細胞突然変異 / 発作性夜間血色素尿症 Less
  • Research Projects

    (22 results)
  • Research Products

    (98 results)
  • Co-Researchers

    (48 People)
  •  敗血症におけるplasminogen activator inhibitor-1阻害の効果検証

    • Principal Investigator
      早川 峰司
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 55060:Emergency medicine-related
    • Research Institution
      Hokkaido University
  •  Blockade of PAI-1 eliminates leukemic stem cells

    • Principal Investigator
      YAHATA Takashi
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Tumor biology
    • Research Institution
      Tokai University
  •  The development of a novel mechanism therapeutic drug for rare intractable inflammatory diseasesPrincipal Investigator

    • Principal Investigator
      MIYATA Toshio
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Applied pharmacology
    • Research Institution
      Tohoku University
  •  Establishment of hematopoietic regeneration by the novel molecular targeting drug

    • Principal Investigator
      YAHATA Takashi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      Tokai University
  •  酸素センサー分子Keap-1の活性阻害薬の探索:酸化ストレスの薬物制御Principal Investigator

    • Principal Investigator
      宮田 敏男
    • Project Period (FY)
      2009
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Kidney internal medicine
    • Research Institution
      Tohoku University
  •  Research on pathophysiology and mechanisms to develop carbonyl stress-related schizophrenia

    • Principal Investigator
      ARAI Makoto
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  ovel cerebroprotectants targeting ER stress or hypoxia inducible factor

    • Principal Investigator
      TAKIZAWA Shunya
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Tokai University
  •  Development of novel compounds that enhance HIF activity and ameliorate chronic hypoxia in diabetic nephropathy and other diseases.Principal Investigator

    • Principal Investigator
      MIYATA Toshio
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Tokai University
  •  Analysis of hypoxia-responsive genes and establishment of markers of ischemic injury

    • Principal Investigator
      NANGAKU Masaomi
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Kidney internal medicine
    • Research Institution
      The University of Tokyo
  •  Inhibition of intra-peritoneal carbonyl stress by carbonyl adsorbing beads or carbonyl stress inhibitor

    • Principal Investigator
      KAKUTA Takatoshi
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Tokai University
  •  Toward better dialysis compatibility: Advances in the biochemistry and pathophysiology of the peritoneal membranesPrincipal Investigator

    • Principal Investigator
      MIYATA Toshio
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Tokai University
  •  Post genome study for mesangium-predominant functional genes

    • Principal Investigator
      KUROKAWA Kiyoshi
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Tokai University
  •  progressive mesangial cell proliferation and expansion in mice overepxressed mesangium-predominant serine protease inhibitor, megsin,

    • Principal Investigator
      INAGI Reiko
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Tokai University
  •  Functional genomics for renal diseases

    • Principal Investigator
      KUROKAWA Kiyoshi
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (A).
    • Research Field
      Kidney internal medicine
    • Research Institution
      Tokai University
  •  Tissue specific transcriptional regulation of mesangium-predominant gene, megsin

    • Principal Investigator
      INAGI Reiko
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Tokai University
  •  Study on the pathological role of AGEs in renal diseasesPrincipal Investigator

    • Principal Investigator
      MIYATA Toshio
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      Kidney internal medicine
    • Research Institution
      Tokai University
  •  Molcular Reguration of Parathyroid Cell Function in Chronic Renal Failure

    • Principal Investigator
      KUROKAWA Kiyosi
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Kidney internal medicine
    • Research Institution
      School of Medicine Tokai University
  •  QUALITATIVE AND QUANTITATIVE ANALYSIS OF GENES EXPRESSED IN CULTURED HUMAN GLOMERULAR MESANGIAL CELLS.Principal Investigator

    • Principal Investigator
      MIYATA Toshio
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Kidney internal medicine
    • Research Institution
      NAGOYA UNIVERSITY
  •  メイラード反応後期生成産物の生理活性の解析Principal Investigator

    • Principal Investigator
      宮田 敏男
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Nagoya University
  •  Pathogenesis of dialysis-related amyloidosis

    • Principal Investigator
      MAEDA Kenji
    • Project Period (FY)
      1994 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Kidney internal medicine
    • Research Institution
      NAGOYA UNIVERSITY
  •  発作性夜間血色素尿症(PNH)の病因研究

    • Principal Investigator
      木下 タロウ
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Osaka University
  •  糖脂質結合型タンパク質の生合成および発作性夜間血色素尿症の病因研究Principal Investigator

    • Principal Investigator
      宮田 敏男
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Hematology
    • Research Institution
      Osaka University

All 2017 2015 2014 2013 2010 2009 2008 2007 2006 2005 Other

All Journal Article Presentation Book Patent

  • [Book] Oxidative Stress in Applied Basic Research and Clinical Practice : 'Renal Disorders'2010

    • Author(s)
      宮田敏男, van Ypersele de Strihou C.
    • Publisher
      Springer(印刷中)
    • Data Source
      KAKENHI-PROJECT-21659213
  • [Book] (Thomas MC, Forbes J, eds)Maillard Reaction : Interface between Aging, Nutrition and Metabolism(A novel mechanism of mental illness : Carbonyl stress induced schizophrenia : A glyoxalase I deficit pedigree with psychosis.)2010

    • Author(s)
      Itokawa M, Arai M, Yoshikawa T, Okazaki Y, Miyata T
    • Publisher
      Cambridge : RSC Publishing
    • Data Source
      KAKENHI-PROJECT-20591383
  • [Journal Article] TGF-β-induced intracellular PAI-1 is responsible for retaining hematopoietic stem cells in the niche2017

    • Author(s)
      Yahata Takashi、Ibrahim Abd Aziz、Muguruma Yukari、Eren Mesut、Shaffer Alexander M.、Watanabe Nobuo、Kaneko Satoko、Nakabayashi Tetsuo、Dan Takashi、Hirayama Noriaki、Vaughan Douglas E.、Miyata Toshio、Ando Kiyoshi
    • Journal Title

      Blood

      Volume: 130 Issue: 21 Pages: 2283-2294

    • DOI

      10.1182/blood-2017-02-767384

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04301, KAKENHI-PROJECT-17H03572, KAKENHI-PROJECT-15K10523
  • [Journal Article] Plasminogen Activator Inhibitor-1 Antagonist TM5484 Attenuates Demyelination and Axonal Degeneration in a Mice Model of Multiple Sclerosis2015

    • Author(s)
      Pelisch N, Dan T, Ichimura A, Sekiguchi H, Vaughan DE, van Ypersele C, Miyata T.
    • Journal Title

      PLoS One.

      Volume: 掲載確定

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249033
  • [Journal Article] Small Molecule Inhibitors of PAI-1 TM5275 and TM5441 Elicit Anti-Angiogenic and Anti-tumorigenic.2015

    • Author(s)
      Placencio VR, Ichimura A, Miyata T, DeClerck YA.
    • Journal Title

      Journal Molecular Cancer Therapeutics.

      Volume: 掲載確定

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249033
  • [Journal Article] Podocyte injury-driven intracapillary plasminogen activator inhibitor type 1 accelerates podocyte loss via uPAR-mediated β1-integrin endocytosis.2015

    • Author(s)
      Kobayashi N, Ueno T, Ohashi K, Yamashita H, Takahashi Y, Sakamoto K, Manabe S, Hara S, Takashima Y, Dan T, Pastan I, Miyata T, Kurihara H, Matsusaka T, Reiser J, Nagata M.
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 308・6 Issue: 6 Pages: F614-F626

    • DOI

      10.1152/ajprenal.00616.2014

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-22249033, KAKENHI-PROJECT-24249033, KAKENHI-PROJECT-25461617, KAKENHI-PROJECT-23249047
  • [Journal Article] Nitric oxide prevents alveolar senescence and emphysema in a mouse model2015

    • Author(s)
      Boe AE, Eren M, Morales-Nebreda L, Murphy SB, Budinger GR, Mutlu GM, Miyata T, Vaughan DE.
    • Journal Title

      PLoS One.

      Volume: 10

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249033
  • [Journal Article] Inhibition of plasminogen activator inhibitor-1 is a potential therapeutic strategy in ovarian cancer.2015

    • Author(s)
      Mashiko S, Kitatani K, Toyoshima M, Ichimura A, Dan T, Usui T, Ishibashi M, Shigeta S, Nagase S, Miyata T, Yaegashi N.
    • Journal Title

      Cancer Biol Ther.

      Volume: 16 Pages: 253-260

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249033
  • [Journal Article] Inhibition of plasminogen activator inhibitor type-1 activity enhances rapid and sustainable hematopoietic regeneration.2014

    • Author(s)
      IbrahimAA,Yahata T,Onizuka M,Dan T,Van Yperscle De Stribou C,Miyata T,Ando K
    • Journal Title

      Stem Cells,

      Volume: 32 Issue: 4 Pages: 946-958

    • DOI

      10.1002/stem.1577

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24390248, KAKENHI-PROJECT-24590361, KAKENHI-PROJECT-26890022
  • [Journal Article] Inhibition of Plasminogen Activator Inhibitor Type-1 Activity Enhances Rapid and Sustainable Hematopoietic Regeneration.2014

    • Author(s)
      Ibrahim AA, Yahata T, Onizuka M, Dan T, van Ypersele de Strihou C, Miyata T, Ando K.
    • Journal Title

      Stem Cells

      Volume: 32 Pages: 946-958

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249033
  • [Journal Article] PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice.2014

    • Author(s)
      Eren M, Boe AE, Murphy SB, Place AT, Nagpal V, Morales-Nebreda L, Urich D, Quaggin SE, Budinger GR, Mutlu GM, Miyata T, Vaughan DE.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 13 Issue: 19 Pages: 7090-7095

    • DOI

      10.1073/pnas.1321942111

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249033
  • [Journal Article] Drug discovery in renal disease--towards a more efficient framework.2014

    • Author(s)
      Miyata T, Ando T, Hiragi H, Watanabe K, Yamamoto F, Vaughan DE, Kurokawa T, Oshima Y, van Ypersele de Strihou C, Takeuchi M.
    • Journal Title

      Nat Rev Nephrol.

      Volume: 10 Issue: 5 Pages: 290-296

    • DOI

      10.1038/nrneph.2014.36

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249033
  • [Journal Article] The PAI-1 antagonist TM5441 attenuates L-NAME-induced hypertension and vascular senescence2013

    • Author(s)
      Boe A, Eren M, Murphy S, Kamide1 C, Ichimura A, Terry D, McAnally D, Smith LH, Miyata T, Vaughan DE
    • Journal Title

      Circulation

      Volume: 128 Issue: 21 Pages: 2318-2324

    • DOI

      10.1161/circulationaha.113.003192

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249033, KAKENHI-PROJECT-25860185
  • [Journal Article] Kidney failure: aims for the next 10 years and barriers to success2013

    • Author(s)
      Remuzzi G, Benigni A, Finkelstein FO, Grunfeld JP, Joly D, Katz I, Liu ZH, Miyata T, Perico N, Rodriguez-Iturbe B, Antiga L, Schaefer F, Schieppati A, Schrier RW, Tonelli M
    • Journal Title

      Lancet

      Volume: 382 Issue: 9889 Pages: 353-362

    • DOI

      10.1016/s0140-6736(13)60438-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249033
  • [Journal Article] TM5275prolongs secreted tissue plasminogen activator retention and enhancesfibrinolysis on vascular endothelial cells.2013

    • Author(s)
      Yasui H, Suzuki Y, Sano H, Suda T, Chida K, Dan T, Miyata T, Urano T
    • Journal Title

      Thromb Res

      Volume: ## Issue: 1 Pages: 100-105

    • DOI

      10.1016/j.thromres.2013.04.003

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590826, KAKENHI-PROJECT-24249033, KAKENHI-PROJECT-24590273, KAKENHI-PROJECT-25461123
  • [Journal Article] A smoll molecule inhibitor to plasminogen activator inhibitor 1 inhibits macrophage migration.2013

    • Author(s)
      Ichimura A, Matsumoto S, Suzuki S, Dan T, Yamaki S, Sato Y, Kiyomoto H, Ishii N, Okada K, Matsuo O, Hou FF, Vaughan DE, van Ypersele de Strihou S, Miyata T.
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: 33 Issue: 5 Pages: 935-942

    • DOI

      10.1161/atvbaha.113.301224

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590219, KAKENHI-PROJECT-23890019, KAKENHI-PROJECT-24249033, KAKENHI-PROJECT-24390118, KAKENHI-PROJECT-24659487
  • [Journal Article] Diabetic nephropathy: are there new and potentially promising therapies targeting oxygen biology?2013

    • Author(s)
      Miyata T, Suzuki N, van Ypersele de Strihou C
    • Journal Title

      Kidney Int

      Volume: 84 Issue: 4 Pages: 693-702

    • DOI

      10.1038/ki.2013.74

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-24116502, KAKENHI-PROJECT-24249033, KAKENHI-PROJECT-25670157
  • [Journal Article] Body weight control by a high-carbohydrate/low-fat diet slows the progression of diabetic kidney damage in an obese, hypertensive, type 2 diabetic rat model2010

    • Author(s)
      Ohtomo S, Izuhara Y, Nangaku M, Dan T, Ito S, Van Ypersele de Strihou C, Miyata T.
    • Journal Title

      J Obesity (未定, In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659213
  • [Journal Article] Enhanced Carbonyl Stress in a Subpopulation of Schizophrenia.2010

    • Author(s)
      Arai M, Yuzawa H, Nohara I, Ohnishi T, Obata N, Iwayama Y, Haga S, Toyota T, Ujike H, Arai M, Ichikawa T, Nishida A, Tanaka Y, Furukawa A, Aikawa Y, Kuroda O, Niizato K, Izawa R, Nakamura K, Mori N, Matsuzawa D, Hashimoto K, Iyo M, Sora I, Matsushita M, Okazaki Y, Yoshikawa T, Miyata T, Itokawa M.
    • Journal Title

      Arch Gen Psychiatry. 67(6)

      Pages: 589-597

    • NAID

      130005395360

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591383
  • [Journal Article] カルボニルストレスとGlyoxalase I2010

    • Author(s)
      新井誠,吉川武男,岡崎祐士,宮田敏男,糸川昌成
    • Journal Title

      分子精神医学 10(3)

      Pages: 52-54

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591383
  • [Journal Article] Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress2010

    • Author(s)
      Brouwers O, Niessen PM, Haenen G, Miyata T, Brownlee M, Stehouwer CD, De Mey JG, Schalkwijk CG.
    • Journal Title

      Diabetologia 53

      Pages: 989-1000

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659213
  • [Journal Article] Effect of edaravone on the estimated glomerular filtration rate (eGFR) in acute ischemic stroke patients with chronic kidney disease2010

    • Author(s)
      Tsukamoto Y, Takizawa S, Takahashi W, Mase H, Miyachi H, Miyata T, Takagi S.
    • Journal Title

      J Stroke Cerebrovasc Dis (未定, In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659213
  • [Journal Article] Prevention and treatment of diabetic nephropathy : new approaches2010

    • Author(s)
      Miyata T, van Ypersele de Strihou C.
    • Journal Title

      Review of Endocrinology (未定, In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659213
  • [Journal Article] A novel inhibitor of plasminogen activator inhibitor-1 provides anti-thrombotic benefits devoid of bleeding effect in non-human primates2010

    • Author(s)
      Izuhara Y, Yamaoka N, Kodama H, Dan T, Takizawa S, Hirayama N, Meguro K, van Yperselede Strihou Charles, Miyata T.
    • Journal Title

      J Cereb Blood Flow Metab 30

      Pages: 904-912

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659213
  • [Journal Article] Advanced glycation end-products, anti hypertensive treatment and diastolic function in patients with hypertension and diastolic dysfunction2010

    • Author(s)
      Hartog JW, van de Wal RM, Schalkwijk CG, Miyata T, Jaarsma W, Plokker HW, van Wijk LM, Smit AJ, van Veldhuisen DJ, Voors AA.
    • Journal Title

      Eur.J.Heart Failure 12

      Pages: 397-403

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659213
  • [Journal Article] Enhanced carbonyl stress in a subpopulation of schizophrenia2010

    • Author(s)
      Arai M, Yuzawa H, Nohara I, Ohnishi T, Obata N, Iwayama Y, Haga S, Toyota T, Ujike H, Arai M, Ichikawa T, Nishida A, Tanaka Y, Furukawa A, Aikawa Y, Kuroda O, Niizato K, Izawa R, Nakamura K, Mori N, Matsuzawa D, Hashimoto K, Iyo M, Sora I, Matsushita M, Okazaki Y, Yoshikawa T, Miyata T, Itokawa M.
    • Journal Title

      Arch Gen Psychiatry (未定, In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659213
  • [Journal Article] Novel mechanism of mental illness : Carbonyl stress induced schizophrenia : a glyoxalase I deficit pedigree withpsychosis.2010

    • Author(s)
      糸川昌成, 新井誠, 吉川武男, 岡崎祐士, 宮田敏男
    • Journal Title

      IMARS Highlights 6(3)

      Pages: 9-13

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591383
  • [Journal Article] Relationship of Skin-autofluorescence to Cardiovascular Disease in Japanese Hemodialysis Patients2010

    • Author(s)
      Tanaka K, Katoh T, Asai J, Nemoto F, Suzuki H, Asahi K, Sato K, Sakaue M, Miyata T, Watanabe T.
    • Journal Title

      Ther Apher Dial (未定, In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659213
  • [Journal Article] Inhibition of prolyl hydroxylase domain-containing protein suppressed 1 ipopolysaccharide-induced TNF-a expression2009

    • Author(s)
      Takeda K, Ichiki T, Narabayashi E, Inanaga K, Miyazaki R, Hashimoto T, Matsuura H, Ikeda J, Miyata T, Sunagawa K.
    • Journal Title

      Arterio Thromb Vas Biol 29

      Pages: 2132-2137

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659213
  • [Journal Article] Metallothionein is upregulated by hypoxia and stabilizes hypoxia-inducible factor in the kidney2009

    • Author(s)
      Kojima I, Tanaka T, Inagi R, Nishi H, Aburatani H, Kato H, Miyata T, Fujita T, Nangaku M.
    • Journal Title

      Kidney Int 75

      Pages: 268-277

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659213
  • [Journal Article] A sartan derivative with a very low angiotensin II receptor affinity ameliorates ischemic cerebral damage2009

    • Author(s)
      Takizawa S, Uesugi T, Nagata E, Takagi S, van Ypersele de Strihou C, Miyata T.
    • Journal Title

      J Cereb Blood Flow Metab 29

      Pages: 1665-1672

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659213
  • [Journal Article] Very high doses of valsartan provide renoprotection independently of blood pressure in a type 2 diabetic nephropathy rat model2009

    • Author(s)
      Tominaga N, Robert A, Izuhara Y, Ohtomo S, Dan T, Chihara K, Kurokawa K, van Ypersele de Strihou C Miyata T.
    • Journal Title

      Nephrology 14

      Pages: 581-587

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659213
  • [Journal Article] Angiotensin II type 1A receptor deficiency and longevity2009

    • Author(s)
      Nishiyama A, Matsusaka T, Miyata T.
    • Journal Title

      Nephrol Dial Transplant 24

      Pages: 3280-3281

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659213
  • [Journal Article] Effects of NXY-059 in experimental stroke : an individual animal meta-analysis2009

    • Author(s)
      Bath PM, Gray LJ, Bath AJ, Buchan A, Miyata T, Green AR : NXY-059 Efficacy Meta-analysis in Individual Animals with Stroke Investigators
    • Journal Title

      British J Pharmacology 157

      Pages: 1157-1171

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659213
  • [Journal Article] Methylglyoxal contributes to the development of insulin resistance and salt sensitivity in Sprague Dawley rats2009

    • Author(s)
      Qi G, Mori T, Jiang Y, Hu C, Osaki Y, Yoneki Y, Sun Y, Hosoya T, Kawamata A, Ogawa S, Nakayama M, Miyata T, Ito S.
    • Journal Title

      J Hyperten 27

      Pages: 1664-1671

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659213
  • [Journal Article] Glyoxalase I overexpression ameliorates renal ischemia-reperfusion injury in rats2009

    • Author(s)
      Kumagai T, Nangaku M, Kojima I, Nagai R, Julie R.Ingelfinger, Miyata T, Fujita T, Inagi R.
    • Journal Title

      Am J Physiol-Renal Physiol 296

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659213
  • [Journal Article] Advanced glycation end products in patients with cerebral infarction2009

    • Author(s)
      Ohnuki Y, Nagano R, Takizawa S, Takagi S, Miyata T.
    • Journal Title

      Intern Med 48

      Pages: 587-591

    • NAID

      130000108031

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659213
  • [Journal Article] Advanced glycation end products in patients with cerebral infarction2009

    • Author(s)
      Ohnuki Y, Nagano R, Takizawa S, Takagi S, Miyata S.
    • Journal Title

      Intern Med (in press)

    • NAID

      130000108031

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591012
  • [Journal Article] Translational medicine : Novel mechanisms and therapeutic options in diabetic nephropathy2009

    • Author(s)
      Miyata T.
    • Journal Title

      Pol Arch Med Wewn 119

      Pages: 261-264

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659213
  • [Journal Article] Diabetic nephropathy : a disorder of oxygen metabolism?2009

    • Author(s)
      Miyata T, van Ypersele de Strihou C.
    • Journal Title

      Nat Rev Nephrol 6

      Pages: 83-95

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659213
  • [Journal Article] Translation of basic science into clinical medicine : Novel targetsfor diabetic nephropathy2009

    • Author(s)
      Miyata T, van Ypersele de Strihou C.
    • Journal Title

      Nephrol Dial Transplant 24

      Pages: 1373-1377

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659213
  • [Journal Article] A novel class of inhibitor of advanced glycation end products ameliorates renal and cardiovascular damage in experimental rat models2008

    • Author(s)
      Izuhara Y, Nangaku M, Takizawa S, Takahashi S, Shao J, Oishi H, Kobayashi H, Charles van Ypersele de Strihou, Miyata T.
    • Journal Title

      Nephrol. Dial. Transpl 23

      Pages: 497-509

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591012
  • [Journal Article] A novel inhibitor of advanced glycation and endoplasmic reticulum stress reduces infarct volume in rat focal cerebral ischemia2007

    • Author(s)
      Takizawa S, Izuhara Y, Kitao Y, HoriO, Ogawa S, Morita Y, Takagi S, Kurokawa K, van Ypersele de Strihou C, Miyata T
    • Journal Title

      Brain Res 1183

      Pages: 124-137

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591012
  • [Journal Article] A novel class of prolyl hydroxylase inhibitors induces angiogenesis and exerts organ protection against ischemia2007

    • Author(s)
      Nangaku M, Izuhara Y, Takizawa S, Yamashita T, Ohneda O, Yamamoto M, van Ypersele de Strihou C, Hirayama N, Miyata T
    • Journal Title

      Arterioscler Thromb Vasc Biol. 27

      Pages: 2548-2554

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591012
  • [Journal Article] Carbonyl stress reduction in peritoneal dialysis fluid : development of a novel high affinity adsorption bead2007

    • Author(s)
      Makoto Yamamoto, Yuko Izuhara, Takatoshi Kakuta, Shunya Takizawa, Akio Fujita, Tatsuhiko Higaki, Charles van Ypersele de Strihou, Toshio Miyata
    • Journal Title

      PD international (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590847
  • [Journal Article] High Glucose VEGF Response to Hypoxia via the Oxidative Stress-Regulated HIF-HRE Pathway2006

    • Author(s)
      Katevetin P, Miyata T, Inagi R, Tanaka T, Sassa R, Ingelfinger JR, Fujita T, Nangaku M.
    • Journal Title

      J Am Soc Nephrol 17

      Pages: 1405-1413

    • Data Source
      KAKENHI-PROJECT-17209030
  • [Journal Article] High Glucose Blunts VEGF Response to Hypoxia via the Oxidative Stress-Regulated HIF-HRE Pathway.2006

    • Author(s)
      Katevetin P, Miyata T, Inagi R, Tanaka T, Sassa R, Ingelfinger JR, Fujita T, Nangaku M
    • Journal Title

      J Am Soc Nephrol 17

      Pages: 1405-1413

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17209030
  • [Journal Article] Renoprotection of angiotensin receptor blockers beyond blood pressure lowering(editorial review)2006

    • Author(s)
      Miyata T, van Ypersele de Stribou C.
    • Journal Title

      Nephrol Dial Transplant 21

      Pages: 846-849

    • Data Source
      KAKENHI-PROJECT-17209030
  • [Journal Article] Renoprotection of angiotensin receptor blockers : beyond blood pressure lowering.2006

    • Author(s)
      Miyata T, van Ypersele de Strihou C
    • Journal Title

      Nephrol Dial Transplant 21(editorial review)

      Pages: 846-849

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17209030
  • [Journal Article] Renoprotection of angiotensin receptor blockers : beyond blood pressure lowering (editorial review).2006

    • Author(s)
      Miyata T, van Ypersele de Strihou C.
    • Journal Title

      Nephrol Dial Transplant 21

      Pages: 846-849

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209030
  • [Journal Article] Induction of renoprotective gene expression by cobalt ameliorates tubulointerstitial Injury in the progressive Thy1 nephritis model.2005

    • Author(s)
      Tanaka T, Matsumoto M, Inagi R, Kojima I, Fujita T, Miyata T, Nangaku M
    • Journal Title

      Kidney Int 68

      Pages: 2714-2725

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17209030
  • [Journal Article] Renoprotective properties of angiotensin receptor blockers beyond blood pressure lowering.2005

    • Author(s)
      Izuhara Y, Nangaku M, Inagl R, Tominaga N, Aizawa T, Kurokawa K, van Ypersele de Strihou C, Miyata T
    • Journal Title

      J Am Soc Nephrol 16

      Pages: 3631-3641

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17209030
  • [Journal Article] Pyridoxamine improves functional, structural, and biochemical alterations of peritoneal membranes in nephrectomized uremic rats on peritoneal dialysis'2005

    • Author(s)
      Takatoshi Kakuta, Reika Tanaka, Yoshinobu Satoh, Yuko Izuhara, Reiko Inagi, Masaomi Nanngaku, Akira Saito, Toshio Miyata
    • Journal Title

      Kidney Int. 68

      Pages: 1326-1336

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590847
  • [Journal Article] Hypoxia-inducible factor (HIF) modulates tubular cell survival in cisplatin nephrotoxicity.2005

    • Author(s)
      Tanaka T, Kojima I, Ohse T, Inagi R, Miyata T, Ingelfinger JR, Fujlta T, Nangaku M
    • Journal Title

      Am J Physiol Renal Physiol 289

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17209030
  • [Journal Article] From molecular footprints of disease to new therapeutic intervention in diabetic nephropathy : a detective story (review).2005

    • Author(s)
      Miyata T, et al.
    • Journal Title

      Cur Drug Target 5

      Pages: 323-329

    • Data Source
      KAKENHI-PROJECT-17209030
  • [Journal Article] A biological role of HIF-1 In the renal medulla.2005

    • Author(s)
      Manotham K, Tanaka T, Ohse T, Kojima I, Miyata T, Inagi R, Tanaka H, Sassa R, Fujita T, Nangaku M
    • Journal Title

      Kidney Int 67

      Pages: 1428-1439

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17209030
  • [Journal Article] Serpinopathy and endoplasmic reticulum stress (editorial review).2005

    • Author(s)
      Miyata T, et al.
    • Journal Title

      Med Mol Morphol 38

      Pages: 73-78

    • Data Source
      KAKENHI-PROJECT-17209030
  • [Journal Article] 統合失調症の分子病態と思春期までの予防戦略

    • Author(s)
      糸川昌成,新井誠,市川智恵,宮下光弘,菊地克史,吉川武男,岡崎祐士,宮田敏男
    • Journal Title

      精神神経学雑誌 (印刷中)

    • NAID

      10029576451

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591383
  • [Journal Article] Protective role of HIF2 alpha against ischemic damage and oxidative stress in the kidney.

    • Author(s)
      Kojima I, Tanaka T, Inagi R, Kato H, Yamashita T, Sakiyama A, Ohneda 0, Takeda N, Sata M, Miyata T, Fujita T, Nangaku M.
    • Journal Title

      J Am Soc Nephrol (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209030
  • [Journal Article] 脳科学研究から見えてきた統合失調症の病態および治療と予防の展開

    • Author(s)
      糸川昌成,新井誠,市川智恵,宮下光弘,吉川武男,岡崎祐士,宮田敏男
    • Journal Title

      精神医学 (印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591383
  • [Journal Article] Protective role of HIF-2 alpha against ischemic damage and oxidative stress in the kidney.

    • Author(s)
      Kojima I, Tanaka T, Inagi R, Kato H, Yamatita T, Sakiyama A, Ohneda O, Takada N, Sata M, Miyata T, Fijita T, Nangaku M
    • Journal Title

      J Am Soc Nephrol (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17209030
  • [Journal Article] Protective role of HIF-2 alpha against ischemic damage and oxidative stress in the kidney

    • Author(s)
      Kojima I, Tanaka T, Inagi R, Kato H, Yamashita T, Sakiyama A, Ohbneda O, Takeda N, sata M, Miyata T, Fujita T, Nangaku M
    • Journal Title

      J Am Soc Nephro in press

    • Data Source
      KAKENHI-PROJECT-17209030
  • [Patent] PAI-1阻害剤の新規用途2014

    • Inventor(s)
      安藤 潔、八幡 崇、宮田 敏男
    • Industrial Property Rights Holder
      安藤 潔、八幡 崇、宮田 敏男
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-04-15
    • Overseas
    • Data Source
      KAKENHI-PROJECT-24590361
  • [Patent] 統合失調症の検査および治療2009

    • Inventor(s)
      糸川昌成,宮田敏男,新井誠
    • Industrial Property Rights Holder
      糸川昌成,宮田敏男,新井誠
    • Patent Publication Number
      2009-039088
    • Filing Date
      2009-02-26
    • Data Source
      KAKENHI-PROJECT-20591383
  • [Patent] 統合失調症の検査および治療2008

    • Inventor(s)
      糸川昌成, 宮田敏男, 新井誠
    • Industrial Property Rights Holder
      糸川昌成, 宮田敏男, 新井誠
    • Industrial Property Number
      2007-214047
    • Filing Date
      2008-07-31
    • Overseas
    • Data Source
      KAKENHI-PROJECT-20591383
  • [Patent] 統合失調症の検査および治療2008

    • Inventor(s)
      糸川昌成,宮田敏男,新井誠
    • Industrial Property Rights Holder
      糸川昌成,宮田敏男,新井誠
    • Filing Date
      2008-07-31
    • Overseas
    • Data Source
      KAKENHI-PROJECT-20591383
  • [Patent] プロリル水酸化酵素阻害剤2006

    • Inventor(s)
      宮田敏男
    • Industrial Property Rights Holder
      宮田敏男
    • Industrial Property Number
      2006-013252
    • Filing Date
      2006-01-20
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17209030
  • [Patent] 腹膜保護剤2005

    • Inventor(s)
      宮田 敏夫, 角田 隆俊
    • Industrial Property Rights Holder
      学校法人東海大学
    • Filing Date
      2005-05-24
    • Data Source
      KAKENHI-PROJECT-17590847
  • [Patent] 腹膜保護剤

    • Inventor(s)
      宮田敏男, 角田隆俊
    • Industrial Property Rights Holder
      学校法人東海大学
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590847
  • [Presentation] PAI-1分子: 新たな役割と臨床応用2013

    • Author(s)
      宮田敏男
    • Organizer
      第75回日本血液学会学術集会
    • Place of Presentation
      さっぽろ芸文館(札幌市)
    • Data Source
      KAKENHI-PROJECT-24249033
  • [Presentation] 大学からの創薬:現状と課題2013

    • Author(s)
      宮田敏男
    • Organizer
      第52回日本薬学会東北支部大会
    • Place of Presentation
      東北大学川内北キャンパス(仙台市)
    • Data Source
      KAKENHI-PROJECT-24249033
  • [Presentation] アカデミアからの新薬開発:意義と現状2013

    • Author(s)
      宮田敏男
    • Organizer
      APSTJ2025WGシンポジウム(日本薬剤学会)
    • Place of Presentation
      UDX Gallery NEXT(秋葉原、東京)
    • Data Source
      KAKENHI-PROJECT-24249033
  • [Presentation] アカデミア発創薬: 意義と課題2013

    • Author(s)
      宮田敏男、糸川昌成
    • Organizer
      第23回日本臨床精神神経薬理学会、第43回日本神経精神薬理学会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄市)
    • Data Source
      KAKENHI-PROJECT-24249033
  • [Presentation] RAS阻害薬の臓器保護について2010

    • Author(s)
      宮田敏男
    • Organizer
      白石医師会講演会
    • Place of Presentation
      仙台
    • Year and Date
      2010-03-09
    • Data Source
      KAKENHI-PROJECT-21659213
  • [Presentation] 大学からの創薬2010

    • Author(s)
      宮田敏男
    • Organizer
      東北大学国際産学連携シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2010-02-22
    • Data Source
      KAKENHI-PROJECT-21659213
  • [Presentation] RAS阻害薬の臓器保護について2010

    • Author(s)
      宮田敏男
    • Organizer
      苫小牧ラジレス講演会
    • Place of Presentation
      苫小牧
    • Year and Date
      2010-03-11
    • Data Source
      KAKENHI-PROJECT-21659213
  • [Presentation] 糖尿病性腎症と酸素代謝異常2010

    • Author(s)
      宮田敏男
    • Organizer
      日本内科学会東北支部・第55回生涯教育講演会
    • Place of Presentation
      仙台
    • Year and Date
      2010-02-20
    • Data Source
      KAKENHI-PROJECT-21659213
  • [Presentation] DRIのポテンシャル-降圧と独立した腎臓保護-2010

    • Author(s)
      宮田敏男
    • Organizer
      DRI FORUM
    • Place of Presentation
      横浜
    • Year and Date
      2010-02-03
    • Data Source
      KAKENHI-PROJECT-21659213
  • [Presentation] 糖尿病性腎症と酸素代謝異常2010

    • Author(s)
      宮田敏男
    • Organizer
      レドックス生命科学第170委員会第22回研究会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-19
    • Data Source
      KAKENHI-PROJECT-21659213
  • [Presentation] RAS阻害薬の臓器保護について2009

    • Author(s)
      宮田敏男
    • Organizer
      Rasilez Expert Meeting in Sapporo
    • Place of Presentation
      札幌
    • Year and Date
      2009-11-28
    • Data Source
      KAKENHI-PROJECT-21659213
  • [Presentation] Interplays among hypoxia, oxidative stress, and advanced glycation?2009

    • Author(s)
      宮田敏男
    • Organizer
      10th International Symposium of the Maillard Reaction
    • Place of Presentation
      Palm Cove, Australia
    • Data Source
      KAKENHI-PROJECT-21659213
  • [Presentation] Development of novel therapeutic agents for the treatment of renal car diovascular diseases : inhibitors of plasminogen inhibitor 1 and oxygen sensor prolylhydroxylase2009

    • Author(s)
      宮田敏男
    • Organizer
      The 1st International Symposium~Challenge to Medical Innovation~
    • Place of Presentation
      仙台
    • Year and Date
      2009-12-07
    • Data Source
      KAKENHI-PROJECT-21659213
  • [Presentation] Abnormalities of oxygen metabolism in diabetic nephropathy ; Hypoxia and oxidative stress2009

    • Author(s)
      宮田敏男
    • Organizer
      第21回腎とフリーラジカル研究会
    • Place of Presentation
      岡山
    • Year and Date
      2009-09-26
    • Data Source
      KAKENHI-PROJECT-21659213
  • [Presentation] 増加する腎臓病-如何に早期に診断し治療するか2009

    • Author(s)
      宮田敏男
    • Organizer
      福島県白河地区学術講演会
    • Place of Presentation
      福島
    • Year and Date
      2009-10-14
    • Data Source
      KAKENHI-PROJECT-21659213
  • [Presentation] COUP-TFIIは、Wnt/β-cateninシグナルの下流でPPARγの発現をエピジェネティックに調節することで脂肪細胞分化を制御する2009

    • Author(s)
      岡村将史, 若林賢一, 堤修一, 宮田敏男, 内藤眞, 浜窪隆雄, 伊藤貞嘉, 油谷浩幸, 児玉龍彦, 酒井寿郎
    • Organizer
      第13回日本心血管内分泌代謝学会
    • Place of Presentation
      埼玉
    • Data Source
      KAKENHI-PROJECT-21659213
  • [Presentation] 糖尿病性腎症と酸素代謝異常について2009

    • Author(s)
      宮田敏男
    • Organizer
      第8回秋田県分子病態研究会
    • Place of Presentation
      秋田
    • Year and Date
      2009-10-09
    • Data Source
      KAKENHI-PROJECT-21659213
  • [Presentation] 増加する腎臓病-如何に早期に診断し治療するか2009

    • Author(s)
      宮田敏男
    • Organizer
      町田RAAフォーラム
    • Place of Presentation
      東京
    • Year and Date
      2009-11-19
    • Data Source
      KAKENHI-PROJECT-21659213
  • [Presentation] 糖尿病性腎症と酸素代謝異常2009

    • Author(s)
      宮田敏男
    • Organizer
      大阪CKDエキスパート会議
    • Place of Presentation
      大阪
    • Year and Date
      2009-11-13
    • Data Source
      KAKENHI-PROJECT-21659213
  • [Presentation] Advanced glycation, hypoxia, and oxidative stress2009

    • Author(s)
      宮田敏男
    • Organizer
      World Congress of Nephrology
    • Place of Presentation
      Milan, Italy
    • Data Source
      KAKENHI-PROJECT-21659213
  • [Presentation] 大学からの創薬の一例-出血性副作用のない経口抗血栓薬(PAI-1阻害薬)2009

    • Author(s)
      宮田敏男
    • Organizer
      第16回理事長ファンドワークショップ
    • Place of Presentation
      岐阜
    • Data Source
      KAKENHI-PROJECT-21659213
  • [Presentation] 新規prolyl hydroxylase 阻害薬がHIF下流因子に与える影響2008

    • Author(s)
      紺谷智、永田栄一郎、清水美衣、瀧澤俊也、高木繁治、宮田敏男
    • Organizer
      第49回日本神経学会総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19591012
  • [Presentation] A novel sartan derivative with very low angiotensin II type 1 receptor affinity reduces infarct volume in rat focal cerebral ischemia2008

    • Author(s)
      Takizawa S, Izuhara Y, Uesugi T, Nagata E, Takagi S, Miyata T
    • Organizer
      The 4th Korean-Japan Stroke Conference
    • Place of Presentation
      Fukuoka
    • Data Source
      KAKENHI-PROJECT-19591012
  • [Presentation] A novel inhibitor of advanced glycation and endoplasmic reticulum stress reduces infarct volume in rat transient focal ischemia2007

    • Author(s)
      Takizawa S, Izuhara Y, Morita Y, Uesugi T, Takagi S, Miyata T
    • Organizer
      XXIIInd International Symposium on Cerebral Blood Flow, Metabolism, and Function
    • Place of Presentation
      Osaka
    • Data Source
      KAKENHI-PROJECT-19591012
  • [Presentation] マウス中大脳動脈永久閉塞モデルでの虚血誘導因子の脳保護効果の検討2007

    • Author(s)
      植杉剛, 森田優子, 瀧澤俊也, 高木繁治, 宮田敏男
    • Organizer
      第48回日本神経学会総会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-19591012
  • [Presentation] inhibiting degradation of hypoxiainducible factor increases neural stem cells in mouse focal ischemia2007

    • Author(s)
      Uesugi T, Takizawa S, Izuhara Y, Morita Y, Takagi S, Miyata T
    • Organizer
      XXIIInd International Symposium on Cerebral Blood Flow, Metabolism, and Function
    • Place of Presentation
      Osaka
    • Data Source
      KAKENHI-PROJECT-19591012
  • [Presentation] Advanced glycation end products in patients with cerebral infarction2007

    • Author(s)
      Takizawa S, Morita Y, Nagano R, Izuhara Y, Takagi S, Miyata T
    • Organizer
      The 2nd Meeting of Asian Stroke Forum
    • Place of Presentation
      Kyoto
    • Data Source
      KAKENHI-PROJECT-19591012
  • [Presentation] 大学からの創薬:現状と課題

    • Author(s)
      宮田敏男
    • Organizer
      日本薬剤学会題27年会
    • Place of Presentation
      神戸
    • Invited
    • Data Source
      KAKENHI-PROJECT-24249033
  • [Presentation] 腎臓病学からの発信~先端創薬と早期探索臨床研究~

    • Author(s)
      宮田敏男
    • Organizer
      旭川慢性
    • Place of Presentation
      旭川
    • Invited
    • Data Source
      KAKENHI-PROJECT-24249033
  • 1.  INAGI Reiko (50232509)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 2.  KUROKAWA Kiyosi (30167390)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 3.  YAHATA Takashi (10398753)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 4.  ANDO Kiyoshi (70176014)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 5.  IBRAHIM Abd Aziz (50738789)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 6.  NANGAKU Masaomi (90311620)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 9 results
  • 7.  TAKIZAWA Shunya (70197234)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  ARAI Makoto (80356253)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 9.  ITOKAWA Masanari (40332324)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 10.  OKAZAKI Yuji (40010318)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  YOHSIKAWA Takeo (30249958)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 12.  OHNISHI Tetsuo (80373281)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 13.  DAN Takashi (00512451)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 14.  ICHIMURA Atsuhiko (10609209)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 15.  MAEDA Kenji (90023853)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  FUKAGAWA Masafumi (00211516)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  HIRAYAMA Noriaki (70238393)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  KAKUTA Takatoshi (50276854)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 19.  木下 タロウ (10153165)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  竹田 潤二 (50163407)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  飛田 美穂 (20147169)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  早川 峰司 (10374282)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  工藤 大介 (30455844)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  星野 耕大 (40762266)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  土田 拓見 (50838654)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  土井 研人 (80505892)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  STERN David
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  MONNIER Vincent M.
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  MEDOF M.Edwa
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  VAN Ypersele
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  JOHN W. Bayn
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  BAYNES John W.
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  C.VAN Ypersele de Striho
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 34.  DE Strihou C
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 35.  BAYNES John
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 36.  DAIVID Stern
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 37.  C.VAN Yperse
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 38.  STERN Daivid
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 39.  花房 規男
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 40.  SUZUKI Yuko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 41.  URANO Tetsumei
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 42.  SUZUKI Norio
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 43.  瀧沢 俊也
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 10 results
  • 44.  岡崎 祐士
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 6 results
  • 45.  松阪 泰二
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 46.  PASTAN Ira
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 47.  松尾 理
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 48.  岡田 清孝
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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