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Mashima Hirosato  眞嶋 浩聡

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MASHIMA Hirosato  眞嶋 浩聡

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Researcher Number 10261869
Other IDs
Affiliation (Current) 2022: 自治医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2015 – 2021: 自治医科大学, 医学部, 教授
2014: 秋田大学, 医学(系)研究科(研究院), 講師
2009 – 2013: Akita University, 医学部, 講師
2007: The University of Tokyo, Faculty of Medicine, Research Associate
2002 – 2006: 東京大学, 医学部附属病院, 助手 … More
2005: The University of Tokyo Hospital, Research Associate, 医学部付属病院, 助手
1999: Assistant Professor, Department of Cell Biology Institute for Molecular & Cellular Regulation, Gunma University, 生体調節研究所, 助手
1998: 群馬大, 生体調節研究所, 助手
1995 – 1997: 群馬大学, 生体調節研究所, 助手 Less
Review Section/Research Field
Principal Investigator
Gastroenterology / Gastroenterology / Basic Section 53010:Gastroenterology-related
Except Principal Investigator
Biological Sciences / Gastroenterology / 内分泌・代謝学
Keywords
Principal Investigator
急性膵炎 / 分化 / AR42J細胞 / S100g / Anxa10 / カルシウム / JAM-1 / トリプシン / アクチビンA / アクチビン受容体 … More / ヒト肝癌細胞 / RB蛋白 / mRNA Differential Display / AR42J / 膵 / mRNA differential display / 胆道学 / 膵臓学 / 膵腺房細胞 / 外分泌 / SNARE / IRF-2 / 膵炎 / 膵外分泌 / S100 / アネキシン / IRF2 / タイトジャンクション(TJ) / 膵内分泌細胞 / Jam-1 / AR42J cells / tight junction (TJ) / differentiation / pancreatic endocrine cells / 細胞内カルシウム / ANXA10 / アミラーゼ分泌 / Rab7 / 酵素顆粒 / リソソーム / カテプシン / オートファジー / エキソサイトーシス / 成熟 / 異所性活性化 … More
Except Principal Investigator
急性膵炎 / オートファジー / 膵内分泌細胞 / インスリン / 分化誘導 / ベータセルリン / 肝細胞増殖因子 / 膵β細胞 / insulin / VacA / G蛋白質 / レセプター / 分子機構 / G蛋白質病 / 遺伝子治療 / 脱感作 / 心肥大 / インバースアゴニスト / 心不全 / VAMP7 / ノックアウトマウス / トリプシン / 膵B細胞 / アクチビン / アクチビンA / differentiation / pancreatic endocrine cell / beta-cell / activin A / betacellulin / hepatocyte growth factor / 再生 / 幹細胞 / 糖尿病 / ランゲルハンス島 / 分化誘導因子 / β細胞 / 増殖因子 / 遺伝子 / pancreatic β cells / regeneration / stem cell / diabetes / islet / ヘリコバクター / 空胞化毒素 / 細菌毒素 / 阻害物質 / 血清成分 / Helicobacter pylori / vacuolating cytotoxin / Mechanism of intoxication / rab7 / 酵素顆粒 / オート-ファジー / 膵臓 / 外分泌 / 膵臓病学 Less
  • Research Projects

    (14 results)
  • Research Products

    (97 results)
  • Co-Researchers

    (14 People)
  •  The role of rab7 on ectopic activation of trypsin and the mechanism of the onset of acute pancreatitis.Principal Investigator

    • Principal Investigator
      MASHIMA Hirosato
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Jichi Medical University
  •  The molecular mechanism of autophagy participates in the onset and progression of acute pancreatitis

    • Principal Investigator
      OHNISHI Hirohide
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Jichi Medical University
  •  The role of calcuim-binding protein in acute pancreatitis: aiming for a new drug discoveryPrincipal Investigator

    • Principal Investigator
      MASHIMA Hirosato
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Jichi Medical University
  •  Identification and functional analysis of SNARE proteins participating in the onset of acute pancreatitis

    • Principal Investigator
      Ohnishi Hirohide
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Gastroenterology
    • Research Institution
      Akita University
  •  Clarify the molecular mechanism of acute pancreatitis and develop a new approach for treatment of pancreatitisPrincipal Investigator

    • Principal Investigator
      MASHIMA Hirosato
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Akita University
  •  Clarification of the molecular mechanism in the defect of pancreatic exocytosis in IRF2^<-/->mice-Searching for a new target of the treatment of acute pancreatitisPrincipal Investigator

    • Principal Investigator
      MASHIMA Hirosato
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Akita University
  •  Analysis of the new function of JAM-1 which is related to the differentiation of pancreatic endocrine cellsPrincipal Investigator

    • Principal Investigator
      MASHIMA Hirosato
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      The University of Tokyo
  •  Mechanism of Helicobacter pylonVacAintoxication

    • Principal Investigator
      HIRAYAMA Toshiya
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Nagasaki University
  •  G蛋白質病と疾患:分子機構の解析とシグナル

    • Principal Investigator
      飯利 太朗
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  膵の分化を誘導する遺伝子及びその情報伝達系の解明Principal Investigator

    • Principal Investigator
      真嶋 浩聡
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Gastroenterology
    • Research Institution
      Gunma University
  •  Regeneration of Pancreatic β-cells

    • Principal Investigator
      KOJIMA Itaru
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      内分泌・代謝学
    • Research Institution
      Gunma University
  •  膵の分化を決定する分化誘動因子及び遺伝子の解明・膵共通前駆細胞のモデル細胞AR42J細胞を利用して-Principal Investigator

    • Principal Investigator
      真嶋 浩聡
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Gastroenterology
    • Research Institution
      Gunma University
  •  Differentiation of Pancreatic Endocrine Cells

    • Principal Investigator
      KOJIMA Itaru
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      内分泌・代謝学
    • Research Institution
      Gunma University
  •  受容体遺伝子導入によるアクチビンの増殖抑制効果の研究Principal Investigator

    • Principal Investigator
      真嶋 浩聡
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Gastroenterology
    • Research Institution
      Gunma University

All 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2005 Other

All Journal Article Presentation Book

  • [Book] 分子生物学が可能とした個別化医療 第19回浜名湖シンポジウム記録集2012

    • Author(s)
      真嶋浩聡,大西洋英
    • Total Pages
      9
    • Publisher
      株式会社アークメディア
    • Data Source
      KAKENHI-PROJECT-24591004
  • [Journal Article] The role of calcium-binding protein S100g (CalbindinD-9K) and annexin A10 in acute pancreatitis2020

    • Author(s)
      Mashima H, Takahashi K, Sekine M, Matsumoto S, Asano T, Uehara T, Fujiwara J, Otake H, Ishii T, Yoshikawa S, Miura T, Koito Y, Kashima H, Matsumoto K, Ohnishi H.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: - Pages: 692-698

    • DOI

      10.1016/j.bbrc.2020.03.155

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08476
  • [Journal Article] 急性膵炎発症のメカニズム2019

    • Author(s)
      眞嶋浩聡、関根匡成、大西洋英
    • Journal Title

      胆と膵

      Volume: 40 Pages: 1065-1072

    • NAID

      130004678077

    • Data Source
      KAKENHI-PROJECT-19K08476
  • [Journal Article] 急性膵炎発症・進展における細胞内小胞輸送の役割2018

    • Author(s)
      高橋健一、眞嶋浩聡、大西洋英
    • Journal Title

      膵臓

      Volume: 33 Pages: 723-729

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K09401
  • [Journal Article] 急性膵炎におけるオートファジーとエンドサイトーシス2018

    • Author(s)
      眞嶋 浩聡, 高橋 健一, 大西 洋英
    • Journal Title

      胆と膵

      Volume: 39 Pages: 139-145

    • Data Source
      KAKENHI-PROJECT-16K09389
  • [Journal Article] 急性膵炎発症・進展における細胞内膜小胞輸送の役割2018

    • Author(s)
      高橋 健一, 眞嶋 浩聡, 大西 洋英
    • Journal Title

      膵臓

      Volume: 33 Pages: 723-729

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K09389
  • [Journal Article] 急性膵炎におけるオートファジーとエンドサイトーシス2018

    • Author(s)
      眞嶋浩聡、高橋健一、大西洋英
    • Journal Title

      胆と膵

      Volume: 39 Pages: 139-145

    • Data Source
      KAKENHI-PROJECT-16K09401
  • [Journal Article] Disruption of Small GTPase Rab7 Exacerbates the Severity of Acute Pancreatitis in Experimental Mouse Models2017

    • Author(s)
      Kenichi Takahashi, Hirosato Mashima, Kouichi Miura, Daichi Maeda, Akiteru Goto, Takashi Goto, Ge-Hong Sun-Wada, Yoh Wada, Hirohide Ohnishi
    • Journal Title

      Scientific Reports

      Volume: 印刷中

    • NAID

      120007089052

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09389
  • [Journal Article] Disruption of Small GTPase Rab7 Exacerbates the Severity of Caerulein-Induced Acute Pancreatitis in Mice2017

    • Author(s)
      Mouse Models. Takahashi K, Mashima H, Miura K, Maeda D, Goto A, Goto T, Sun-Wada GH, Wada Y, Ohnishi H.
    • Journal Title

      Scientific Reports

      Volume: 7 Pages: 2817-2817

    • DOI

      10.1038/s41598-017-02988-3

    • NAID

      120007089052

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K08646, KAKENHI-PROJECT-16K09337, KAKENHI-PROJECT-16K09401, KAKENHI-PUBLICLY-16H01201
  • [Journal Article] 急性膵炎におけるカルシウムシグナル異常2016

    • Author(s)
      眞嶋浩聡、大西洋英
    • Journal Title

      膵臓

      Volume: 31 Pages: 17-24

    • NAID

      130005137836

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K09401
  • [Journal Article] 急性膵炎とオートファジー2016

    • Author(s)
      眞嶋浩聡、大西洋英
    • Journal Title

      肝胆膵

      Volume: 73 Pages: 243-249

    • Data Source
      KAKENHI-PROJECT-16K09401
  • [Journal Article] 膵炎とオートファジー2015

    • Author(s)
      真嶋浩聡、大西洋英
    • Journal Title

      G. I. Research

      Volume: .

    • Data Source
      KAKENHI-PROJECT-24591004
  • [Journal Article] 膵ホルモンおよびActivin Aと膵機能2014

    • Author(s)
      大西洋英、眞嶋浩聡
    • Journal Title

      胆と膵

      Volume: 35 Pages: 317-322

    • Data Source
      KAKENHI-PROJECT-25670364
  • [Journal Article] The roles of interferon regulatory factor (IRF) 1 and IRF2 in the progression of human pancreatic cancer.2014

    • Author(s)
      Sakai T, Mashima M, Yamada Y, Goto T, Sato W, Dohmen T, Kamada K, Yoshioka M, Uchinami H, Yamamoto Y, Ohnishi H.
    • Journal Title

      Pancreas

      Volume: 未定

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25670364
  • [Journal Article] IRF2KOマウスを用いて、膵炎発症のメカニズムの解明を目指す2014

    • Author(s)
      真嶋浩聡、大西洋英
    • Journal Title

      アルコールと医学生物学

      Volume: 印刷中

    • Data Source
      KAKENHI-PROJECT-24591004
  • [Journal Article] 急性膵炎発症のメカニズム2014

    • Author(s)
      真嶋浩聡、大西洋英
    • Journal Title

      胆と膵

      Volume: 35 Pages: 1001-1009

    • NAID

      130004678077

    • Data Source
      KAKENHI-PROJECT-24591004
  • [Journal Article] 膵疾患におけるInterferon Regulatory Factorの役割2014

    • Author(s)
      真嶋浩聡、酒井利隆、大西洋英
    • Journal Title

      膵臓

      Volume: 29 Pages: 23-31

    • NAID

      130004496046

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591004
  • [Journal Article] 慢性膵炎におけるNF-kBの活性亢進とその役割2014

    • Author(s)
      真嶋浩聡、大西洋英
    • Journal Title

      肝胆膵

      Volume: 29 Pages: 537-545

    • Data Source
      KAKENHI-PROJECT-24591004
  • [Journal Article] The roles of interferon regulatory factors 1 and 2 in the progression of human pancreatic cancer.2014

    • Author(s)
      Sakai T, Mashima H, Yamada Y, Goto T, Sato W, Dohmen T, Kamada K, Yoshioka M, Uchinami H, Yamamoto Y, Ohnishi H.
    • Journal Title

      Pancreas

      Volume: 43 Pages: 909-916

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25670364
  • [Journal Article] 急性膵炎発症のメカニズム2014

    • Author(s)
      眞嶋浩聡, 大西洋英
    • Journal Title

      日本消化器病学会雑誌

      Volume: 111 Pages: 1550-1560

    • NAID

      130004678077

    • Data Source
      KAKENHI-PROJECT-25670364
  • [Journal Article] 急性膵炎発症のメカニズム2014

    • Author(s)
      真嶋浩聡、大西洋英
    • Journal Title

      日本消化器病学会誌

      Volume: 印刷中

    • NAID

      130004678077

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591004
  • [Journal Article] IRF2KOマウスを用いて、膵炎発症のメカニズムの解明を目指す2014

    • Author(s)
      眞嶋浩聡、大西洋英
    • Journal Title

      アルコールと医学生物学

      Volume: 32 Pages: 12-18

    • Data Source
      KAKENHI-PROJECT-25670364
  • [Journal Article] 膵炎の概念と分類 急性膵炎発症のメカニズム2014

    • Author(s)
      眞嶋浩聡、大西洋英
    • Journal Title

      胆と膵

      Volume: 35 Pages: 1001-1009

    • Data Source
      KAKENHI-PROJECT-25670364
  • [Journal Article] The roles of interferon regulatory factor (IRF) 1 and IRF2 in the progression of human pancreatic cancer2014

    • Author(s)
      Sakai T, Mashima H, Yamada Y, Goto T, Sato W, Dohmen T, Kamada K, Yoshioka M, Uchinami H, Yamamoto Y, Ohnishi H
    • Journal Title

      Pancreas

      Volume: 印刷中

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591004
  • [Journal Article] INSL5 may be a unique marker of colorectal endocrine cells and neuroendocrine tumors.2013

    • Author(s)
      Mashima H, Ohno H, Yamada Y, Sakai T, Ohnishi H.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 432 Pages: 586-592

    • DOI

      10.1016/j.bbrc.2013.02.042

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590911, KAKENHI-PROJECT-24591004
  • [Journal Article] 膵線維化と膵星細胞2013

    • Author(s)
      真嶋浩聡、大西洋英
    • Journal Title

      SURGERY FRONTIER

      Volume: 20 Pages: 320-323

    • Data Source
      KAKENHI-PROJECT-24591004
  • [Journal Article] Functional roles of TGF-β1 in intestinal epithelial cells through Smad-dependent and Non-Smad pathways.2013

    • Author(s)
      Yamada Y, Mashima H, Sakai T, Matsuhashi T, Jin M, Ohnishi H.
    • Journal Title

      Dig Dis Sci.

      Volume: 58 Pages: 120-1217

    • DOI

      10.1007/s10620-012-2515-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591004
  • [Journal Article] 急性膵炎の発症のメカニズム~細胞内では何が起きているのか?~2013

    • Author(s)
      真嶋 浩聡, 大西 洋英.
    • Journal Title

      胆と膵

      Volume: 34 Pages: 1035-1041

    • Data Source
      KAKENHI-PROJECT-25670364
  • [Journal Article] 急性膵炎の発症のメカニズム ~細胞内では何が起きているか~2013

    • Author(s)
      真嶋浩聡、大西洋英
    • Journal Title

      胆と膵

      Volume: 34 Pages: 1035-1041

    • Data Source
      KAKENHI-PROJECT-24591004
  • [Journal Article] 遺伝子改変マウスを用いた急性膵炎研究の現状と今後の展望2012

    • Author(s)
      真嶋浩聡,大西洋英
    • Journal Title

      膵臓

      Volume: 27 Pages: 584-592

    • NAID

      10031074701

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591004
  • [Journal Article] 膵線維化の病態2012

    • Author(s)
      真嶋浩聡,大西洋英
    • Journal Title

      肝胆膵

      Volume: 65 Pages: 329-336

    • Data Source
      KAKENHI-PROJECT-24591004
  • [Journal Article] Interferon Regulatory Factor-2 Regulates Exocytosis in Mechanisms Mediated by SNAREs in Pancreatic Acinar Cells2011

    • Author(s)
      Mashima H, Sato T, Horie Y, Ohteki T, Ohnishi H
    • Journal Title

      Gastroenterology

      Volume: 141 Pages: 1102-1113

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590872
  • [Journal Article] 膵線維化とその治療戦略2010

    • Author(s)
      真嶋浩聡, 大西洋英
    • Journal Title

      成人病と生活習慣病

      Volume: 40 Pages: 35-39

    • Data Source
      KAKENHI-PROJECT-21590872
  • [Journal Article] IL-13 promotes the proliferation of rat pancreatic stellate cells through the suppression of NF-<kappa>B/TGF-1 pathway.2010

    • Author(s)
      Shinozaki S, 真嶋浩聡, 大西洋英, Sugano K.
    • Journal Title

      Biochemical and Biophysical Research Communications 393

      Pages: 61-65

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590872
  • [Journal Article] 膵線維化とその治療戦略2010

    • Author(s)
      真嶋浩聡、大西洋英
    • Journal Title

      成人病と生活習慣病 40

      Pages: 35-39

    • Data Source
      KAKENHI-PROJECT-21590872
  • [Journal Article] IL-13 promotes the proliferation of rat pancreatic stellate cells through the suppression of NF-<kappa>B /TGF-1 pathway2010

    • Author(s)
      Shinozaki S, Mashima H, Ohnishi H, Sugano K
    • Journal Title

      Biophysical Research Communications

      Volume: 393 Pages: 61-65

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590872
  • [Journal Article] MCP-1 inhibits DNA synthesis in rat pancreatic stellate cells.2010

    • Author(s)
      Kamada K, 真嶋浩聡, Goto T, 大西洋英
    • Journal Title

      Akitaigaku (In press)

    • NAID

      110008439108

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590872
  • [Journal Article] 膵外分泌における腺房細胞内情報伝達と分子メカニズム胆と膵2010

    • Author(s)
      真嶋浩聡, 大西洋英
    • Volume
      31
    • Pages
      535-539
    • Data Source
      KAKENHI-PROJECT-21590872
  • [Journal Article] 膵外分泌における腺房細胞内情報伝達と分子メカニズム2010

    • Author(s)
      真嶋浩聡、大西洋英
    • Journal Title

      胆と膵

      Volume: 31 Pages: 535-539

    • Data Source
      KAKENHI-PROJECT-21590872
  • [Journal Article] MCP-1 inhibits DNA synthesis in rat pancreatic stellate cells2009

    • Author(s)
      Kamada K, Mashima H, Goto T, Ohnishi H
    • Journal Title

      Akitaigaku

      Volume: 36 Pages: 185-194

    • NAID

      110008439108

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590872
  • [Journal Article] Up-regulation of JAM-1 in AR42J cells treated with activin A and betacellulin and the diabetic regenerating islets.2008

    • Author(s)
      Yoshikumi Y, Ohno H, Suzuki J, Isshiki M, Morishita Y, Ohnishi H, Yasuda H, Omata M, Fuiita T, Mashima H.
    • Journal Title

      Endocrine Journal(掲載確定)

    • NAID

      10022609359

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17590616
  • [Journal Article] Involvement of VAMP7 in Human Gastric Epithelial Cell Vacuolation Induced by Helicobacter pylori-produced VacA.2008

    • Author(s)
      Mashima H, Suzuki J, Hirayama T, Yoshikumi Y, Ohno H, Ohnishi H, Yasuda H, Fujita T, Omata M.
    • Journal Title

      Infection And Immunity (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17590616
  • [Journal Article] Involvement of VAMP7 in Human Gastric Epithelial Cell Vacuolation Induced by Helicobacter pylori-produced VacA.2008

    • Author(s)
      Mashima H, Suzuki J, Hirayama T, Yoshikumi Y, Ohno H, Ohnishi H, Yasuda H, Fujta T, Omata M.
    • Journal Title

      Infection And Immunity(掲載確定)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17590616
  • [Journal Article] Up-regulation of JAM-1 in AR42J cells treated with activin A and betacellulin and the diabetic regenerating islets.2008

    • Author(s)
      Yoshikumi Y, Ohno H, Suzuki J, Isshiki M, Morishita Y, Ohnishi H, Yasuda H, Omata M, Fujita T, Mashima H.
    • Journal Title

      Endocrine Journal (In press)

    • NAID

      10022609359

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17590616
  • [Journal Article] Indian hedgehog promotes the migration of rat activated pancreatic stellate cells by increasing membrane type-1 matrix metalloproteinase on the plasma membrane.2008

    • Author(s)
      Shinozaki S, Ohnishi H, Hama K, Yamamoto H, Osawa, H, Sato K, Tamada K, Mashima H, Sugano K.
    • Journal Title

      Journal of Cellular Physiology(掲載確定)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17590616
  • [Journal Article] Involvement of membrane-type bile acid receptor M-BAR/TGR5 in bile acid-induced activation of epidermal growth factor receptor and mitogen-activated protein kinases in gastric carcinoma cells2007

    • Author(s)
      Yasuda H, Hirata S, Inoue K, Mashima H, Ohnishi H, Yoshida M.
    • Journal Title

      Biochem Biophys Res Commun 354

      Pages: 154-159

    • Data Source
      KAKENHI-PROJECT-17590616
  • [Journal Article] Roles of CTPL/Sfxn3 and Sfxn family members in pancreaticislet.2005

    • Author(s)
      Yoshikumi Y, Mashima H, Ueda N, Ohno H, Suzuki J, Tanaka S, Hayashi M, Sekine N, Ohnishi H, Yasuda H, Iiri T, Omata M, Fujita T, Kojima I.
    • Journal Title

      Journal of Cellular Biochemistry 95

      Pages: 1157-1168

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17590616
  • [Journal Article] Roles of CTPL/Sfxn3 and Sfxn family members in pancreatic islet2005

    • Author(s)
      Yoshikumi Y, Mashima H, Ueda N, Ohno H, Suzuki J, Tanaka S, Hayashi M, Sekine N, Ohnishi H, Yasuda H, Iiri T, Omata M, Fujita T, Kojima I.
    • Journal Title

      Journal of Cellular Biochemistry 95

      Pages: 1157-1168

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590616
  • [Journal Article] Roles of CTPL/Sfxn3 and Sfxn family members in pancreatic islet.2005

    • Author(s)
      Mashima H
    • Journal Title

      J.Cell Biochem. (In press)

    • Data Source
      KAKENHI-PROJECT-12136202
  • [Journal Article] Up-regulation of JAM-1 in AR42J cells treated with activin A and betacellulin and the diabetic regenerating islets

    • Author(s)
      Yoshikumi Y, Ohno H, Suzuki J, Isshiki M, Morishita Y, Ohnishi H, Yasuda H, Omata M, Fujita T, Mashima H.
    • Journal Title

      Endocrine Journal (in press)

    • NAID

      10022609359

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590616
  • [Journal Article] 遺伝子改変マウスを用いた急性膵炎研究の現状と今後の展望

    • Author(s)
      真嶋浩聡, 大西洋英
    • Journal Title

      膵臓

      Volume: (in press)

    • NAID

      10031074701

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590872
  • [Journal Article] 遺伝子改変マウスを用いた急性膵炎研究の現状と今後の展望

    • Author(s)
      真嶋浩聡、大西洋英
    • Journal Title

      膵臓(日本膵臓学会誌)

      Volume: (In press)

    • NAID

      10031074701

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590872
  • [Journal Article] Involvement of VAMP7 in Human Gastric Epithelial Cell Vacuolation Induced by Helicobacter pylori-produced VacA

    • Author(s)
      Mashima H, Suzuki J, Hirayama T, Yoshikumi Y, Ohno H, Ohnishi H, Yasuda H, Fujita T, Omata M.
    • Journal Title

      Infection And Immunity (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590616
  • [Presentation] 膵外分泌恒常性維持におけるRab7機能の検討2018

    • Author(s)
      高橋健一、眞嶋浩聡、大西洋英
    • Organizer
      第104回日本消化器病学会総会
    • Data Source
      KAKENHI-PROJECT-16K09401
  • [Presentation] 低分子量Gタンパク質Rab7の膵外分泌腺における機能解析2018

    • Author(s)
      高橋 健一, 眞嶋 浩聡, 大西 洋英
    • Organizer
      日本膵臓学会総会
    • Data Source
      KAKENHI-PROJECT-16K09389
  • [Presentation] 基礎研究から紐解く膵・胆道の恒常性とその破綻 膵外分泌腺恒常性維持におけるRab7機能の検討2018

    • Author(s)
      高橋 健一, 眞嶋 浩聡, 大西 洋英
    • Organizer
      日本消化器病学会総会
    • Data Source
      KAKENHI-PROJECT-16K09389
  • [Presentation] 膵臓特異的Rab7ノックアウトマウスによるオートファジー成熟過程の障害はセルレイン誘発急性膵炎を悪化させる2017

    • Author(s)
      高橋健一、眞嶋浩聡、大西洋英
    • Organizer
      第104回日本消化器病学会総会
    • Data Source
      KAKENHI-PROJECT-16K09401
  • [Presentation] Rab7のオートファジー・エンドサイトーシスを介した急性膵炎での保護的作用の検討2017

    • Author(s)
      高橋健一、眞嶋浩聡、大西洋英
    • Organizer
      第48回日本膵臓学会大会
    • Data Source
      KAKENHI-PROJECT-16K09401
  • [Presentation] 膵臓特異的Rab7ノックアウトによるオートファジー成熟過程の障害はセルレイン誘発急性膵炎を悪化させる2017

    • Author(s)
      高橋健一、眞嶋浩聡、大西洋英
    • Organizer
      第103回日本消化器病学会総会
    • Place of Presentation
      東京都新宿区
    • Data Source
      KAKENHI-PROJECT-16K09389
  • [Presentation] Rab7のオートファジー・エンドサイトーシスを介した急性膵炎での保護的作用の検討2017

    • Author(s)
      高橋健一、眞嶋浩聡、大西洋英
    • Organizer
      第48回日本膵臓学会大会
    • Place of Presentation
      京都府京都市
    • Data Source
      KAKENHI-PROJECT-16K09389
  • [Presentation] Rab7 のオートファジー・エンドサイトーシスを介した急性膵炎での保護的 作用の検討2017

    • Author(s)
      高橋健一、眞嶋浩聡、大西洋英
    • Organizer
      第48回日本膵臓学会大会
    • Data Source
      KAKENHI-PROJECT-16K09389
  • [Presentation] 膵臓特異的Rab7ノックアウトによるオートファジー成熟過程の傷害はセルレイン誘発性急性膵炎を悪化させる。2017

    • Author(s)
      高橋健一、眞嶋浩聡、大西洋英
    • Organizer
      第103回日本消化器病学会総会
    • Data Source
      KAKENHI-PROJECT-16K09389
  • [Presentation] 急性膵炎発症のメカニズムー新たな膵炎治療法の開発を目指してー2015

    • Author(s)
      真嶋浩聡
    • Organizer
      滋賀消化器病研究会
    • Place of Presentation
      滋賀県大津市 ピアザ淡海
    • Year and Date
      2015-02-28
    • Invited
    • Data Source
      KAKENHI-PROJECT-24591004
  • [Presentation] 膵臓癌におけるIRF1, IRF2の役割2014

    • Author(s)
      真嶋浩聡、酒井利隆、山田由美、後藤隆、佐藤亘、鎌田健太郎、道免孝洋、大西洋英
    • Organizer
      第48回膵臓病研究会
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-24591004
  • [Presentation] IRF2KOマウスを用いて、膵炎発症のメカニズムの解明を目指す。2013

    • Author(s)
      真嶋浩聡、大西洋英
    • Organizer
      第32回アルコール医学生物学研究会、
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24591004
  • [Presentation] 急性膵炎におけるVAMP7の役割2013

    • Author(s)
      真嶋浩聡、大西洋英
    • Organizer
      第44回日本膵臓学会大会
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-24591004
  • [Presentation] INSL5は大腸内分泌細胞の特徴的なマーカーであり、直腸神経内分泌細胞の発症に関与している可能性がある2013

    • Author(s)
      真嶋浩聡、大野秀樹、大西洋英
    • Organizer
      第55回日本消化器病学会大会(JDDW2013)
    • Place of Presentation
      品川
    • Data Source
      KAKENHI-PROJECT-24591004
  • [Presentation] IRF2KOマウスを用いて、膵炎発症のメカニズムの解明を目指す。2013

    • Author(s)
      真嶋浩聡、大西洋英
    • Organizer
      第50回日本臨床分子医学会学術集会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24591004
  • [Presentation] IRF2KOマウスを用いて、膵炎発症のメカニズムの解明を目指す2013

    • Author(s)
      真嶋浩聡、大西洋英
    • Organizer
      第50回日本臨床分子医学会学術集会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24591004
  • [Presentation] 急性膵炎におけるVAMP7の役割2013

    • Author(s)
      眞嶋浩聡
    • Organizer
      第44回に本膵臓学会
    • Place of Presentation
      仙台市
    • Data Source
      KAKENHI-PROJECT-25670364
  • [Presentation] INSL5 indicates a unique population of neuroendocrine cells in the colorectal epithelium.2013

    • Author(s)
      Mashima H, Yamada Y, Sakai T, Ohnishi H.
    • Organizer
      Annual meeting of American Gastroenterological Association, Digestive Disease Week 2013
    • Place of Presentation
      Orlando (USA)
    • Data Source
      KAKENHI-PROJECT-24591004
  • [Presentation] Searching for the primary target of IRF2 in regulated exocytosis in the pancreas.2012

    • Author(s)
      Mashima H, Ohnishi H
    • Organizer
      Digestive Disease Week 2012,
    • Place of Presentation
      San Diego
    • Data Source
      KAKENHI-PROJECT-24591004
  • [Presentation] IRF2KOマウスを用いた急性膵炎原因遺伝子へのアプローチ2012

    • Author(s)
      真嶋浩聡,大西洋英
    • Organizer
      第43回日本膵臓学会大会
    • Place of Presentation
      山形
    • Data Source
      KAKENHI-PROJECT-24591004
  • [Presentation] 急性膵炎モデルIRF2KOマウスを用いた急性膵炎原因遺伝子へのアプローチ2012

    • Author(s)
      真嶋浩聡,大西洋英
    • Organizer
      第98回日本消化器病学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24591004
  • [Presentation] Irf2-/-膵は急性膵炎早期のモデルであり、実験的膵炎に対しては耐性を示す。2011

    • Author(s)
      真嶋浩聡、大西洋英
    • Organizer
      第42回日本膵臓学会大会
    • Place of Presentation
      青森
    • Year and Date
      2011-07-30
    • Data Source
      KAKENHI-PROJECT-21590872
  • [Presentation] Irf2-/-膵は急性膵炎早期のモデルであり、実験的膵炎に対しては耐性を示す2011

    • Author(s)
      真嶋浩聡, 大西洋英
    • Organizer
      第42回日本膵臓学会大会
    • Place of Presentation
      青森
    • Year and Date
      2011-07-30
    • Data Source
      KAKENHI-PROJECT-21590872
  • [Presentation] IRF2膵調節性外分泌に重要な役割を果たし、急性膵炎モデルIRF2KOマウスを用いて急性膵炎発症の分子メカニズムの解明を目指す2011

    • Author(s)
      真嶋浩聡, 大西洋英
    • Organizer
      第19回浜名湖シンポジウム
    • Place of Presentation
      浜松
    • Year and Date
      2011-12-23
    • Data Source
      KAKENHI-PROJECT-21590872
  • [Presentation] 急性膵炎初期像を模倣するモデル動物IRF2KOマウスにおける膵再生及び線維化の解析2011

    • Author(s)
      真嶋浩聡, 大西洋英
    • Organizer
      第82回日本消化器内視鏡学会総会(JDDW2011)
    • Place of Presentation
      福岡
    • Year and Date
      2011-10-21
    • Data Source
      KAKENHI-PROJECT-21590872
  • [Presentation] The pancreas of Irf2-/-mice presented a very early feature of acute pancreatitis and a milder response in cerulein-induced pancreatitis2011

    • Author(s)
      Mashima H, Sato T, Horie Y, Ohteki T, Ohnishi H
    • Organizer
      American Gastroenterological Association (Digestive Disease Week)
    • Place of Presentation
      Chicago
    • Year and Date
      2011-05-07
    • Data Source
      KAKENHI-PROJECT-21590872
  • [Presentation] 急性膵炎初期像を模倣するモデル動物IRF2 KOマウスにおける膵再生及び線維化の解析2011

    • Author(s)
      真嶋浩聡、大西洋英
    • Organizer
      第82回 日本消化器内視鏡学会総会(JDDW2011)
    • Place of Presentation
      福岡
    • Year and Date
      2011-10-21
    • Data Source
      KAKENHI-PROJECT-21590872
  • [Presentation] IRF2は膵調節性外分泌に重要な役割を果たし、急性膵炎モデルIRF2KOマウスを用いて急性膵炎発症の分子メカニズムの解明を目指す。2011

    • Author(s)
      真嶋浩聡、大西洋英
    • Organizer
      第19回浜名湖シンポジウム
    • Place of Presentation
      浜松
    • Year and Date
      2011-12-23
    • Data Source
      KAKENHI-PROJECT-21590872
  • [Presentation] The pancreas of Irf2-/- mice presented a very early feature of acute pancreatitis and a milder response in cerulein-induced pancreatitis2011

    • Author(s)
      Mashima H, Sato T, Horie Y, Ohteki T, Ohnishi H
    • Organizer
      American Gastroenterological Association (Di gestive Disease Week)
    • Place of Presentation
      Chigago
    • Year and Date
      2011-05-07
    • Data Source
      KAKENHI-PROJECT-21590872
  • [Presentation] Interferon regulatory factor-2 plays a pivotal role in exocytosis in pancreatic acinar cells.2010

    • Author(s)
      Mashima H, Sato T, Horie Y, Ohteki T, Ohnishi H.
    • Organizer
      American Gastroenterological Association (Digestive Disease Week)
    • Place of Presentation
      New Orleans (U S A)
    • Year and Date
      2010-05-07
    • Data Source
      KAKENHI-PROJECT-21590872
  • [Presentation] Interferon regulatory factor-2 plays a pivotal role in exocytosis in pancreatic acinar cells2010

    • Author(s)
      Mashima H, Sato T, Horie Y, Ohteki T, Ohnishi H
    • Organizer
      American Gastroenterological Association (Digestive Disease Week)
    • Place of Presentation
      New Orleans
    • Year and Date
      2010-05-07
    • Data Source
      KAKENHI-PROJECT-21590872
  • [Presentation] IRF-2は膵腺房細胞の調節性外分泌機構に重要な役割を果たす-Irf2-/-膵 : 急性膵炎における膵外分泌異常のモデルとしての可能性-2010

    • Author(s)
      真嶋浩聡、堀江泰夫、大西洋英
    • Organizer
      第52回日本消化器病学会大会(第18回JDDW)
    • Place of Presentation
      横浜
    • Year and Date
      2010-10-15
    • Data Source
      KAKENHI-PROJECT-21590872
  • [Presentation] Interferon regulatory factor-2 plays a pivotal role in exocytosis in pancreatic acinar cells2010

    • Author(s)
      Mashima H, Sato T, Horie Y, Ohteki T, Ohnishi H
    • Organizer
      Joint Meeting of the International Association of Pancreatology and the Japan Pancreas Society
    • Place of Presentation
      福岡
    • Year and Date
      2010-07-12
    • Data Source
      KAKENHI-PROJECT-21590872
  • [Presentation] IRF-2は膵腺房細胞の調節性外分泌機構に重要な役割を果たす-Irf2-/-膵:急性膵炎における膵外分泌異常のモデルとしての可能性2010

    • Author(s)
      真嶋浩聡, 堀江泰夫, 大西洋英
    • Organizer
      第52回日本消化器病学会大会(第18回JDDW)
    • Place of Presentation
      横浜
    • Year and Date
      2010-10-15
    • Data Source
      KAKENHI-PROJECT-21590872
  • [Presentation] Interferon regulatory factor-2 plays a pivotal role in exocytosis in pancreatic acinar cells.2010

    • Author(s)
      Mashima H, Sato T, Horie Y, Ohteki T, Ohnishi H
    • Organizer
      Joint Meeting of the International Association of Pancreatology and the Japan Pancreas Society
    • Place of Presentation
      福岡
    • Year and Date
      2010-07-12
    • Data Source
      KAKENHI-PROJECT-21590872
  • [Presentation] Up-regulation of jam-1 in AR42J cells treated with activin A and betacellulin and the diabetic regenerating islets2009

    • Author(s)
      Mashima H, Yoshikumi Y, Ohnishi H
    • Organizer
      The International Pancreatic Research Forum
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-21590872
  • [Presentation] The Role of VAMP7 on VacA-induced Vacuolation.2007

    • Author(s)
      Mashima H, Suzuki J, Yoshikumi Y, Ohno H, Omata M.
    • Organizer
      Digestive Disease Week
    • Place of Presentation
      Washington
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590616
  • [Presentation] The Role of VAMP7 on VacA-induced Vacuolation2007

    • Author(s)
      Mashima H, Suzuki J, Yoshikumi Y, Ohno H, Omata M.
    • Organizer
      Digestive Disease Week
    • Place of Presentation
      Washington
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590616
  • [Presentation] 膵の分化におけるJAMの新たな役割2005

    • Author(s)
      吉汲祐加子、真嶋浩聡, 他
    • Organizer
      日本消化器病関連学会週間
    • Place of Presentation
      福岡
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590616
  • [Presentation] New Role of JAM-1related to the differentiation of pancreas2005

    • Author(s)
      Yoshikumi Y, Mashima H, Suzuki J, Ohno H, Omata M.
    • Organizer
      Digestive Disease Week Japan
    • Place of Presentation
      Fukuoka
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590616
  • [Presentation] Involvement of the calcium-binding protein in the onset of acute pancreatitis.

    • Author(s)
      Hirosato Mashima, Noboru Watanabe, Suguru Arata, Hirohide Ohnishi
    • Organizer
      Digiestive Disease Week 2015
    • Place of Presentation
      Washington
    • Year and Date
      2015-05-16 – 2015-05-19
    • Data Source
      KAKENHI-PROJECT-24591004
  • [Presentation] Involvement of the calcium-binding protein in the onset of acute pancreatitis.

    • Author(s)
      Hirosato Mashima, Noboru Watanabe, Suguru Arata, Kenichi Takahashi, Hirohide Ohnishi
    • Organizer
      Digestive Disease Week 2015
    • Place of Presentation
      米国、ワシントン
    • Year and Date
      2015-05-16 – 2015-05-19
    • Data Source
      KAKENHI-PROJECT-25670364
  • [Presentation] 二種類のカルシウム結合蛋白と急性膵炎の関連の検討

    • Author(s)
      真嶋浩聡、渡部昇、荒田英、大西洋英
    • Organizer
      第46回日本膵臓学会大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-06-19 – 2015-06-20
    • Data Source
      KAKENHI-PROJECT-24591004
  • [Presentation] 二種類のカルシウム結合蛋白と急性膵炎の関連の検討

    • Author(s)
      眞嶋浩聡、大西洋英
    • Organizer
      日本膵臓学会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-06-19 – 2015-06-20
    • Data Source
      KAKENHI-PROJECT-25670364
  • 1.  OHNISHI Hirohide (00313023)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 70 results
  • 2.  MIURA Kouichi (90375238)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 3.  KOJIMA Itaru (60143492)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  SHIBATA Hiroshi (20235584)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  HIRAYAMA Toshiya (50050696)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  飯利 太朗 (90313022)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  槙田 紀子 (60353455)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  藤田 敏郎 (10114125)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  安田 宏 (80262129)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  堀江 泰夫 (30282164)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  張 有青 (10302499)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  大野 秀樹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  前田 大地
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  和田 洋
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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