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Sada Kiyonao  定 清直

… Alternative Names

SADA Kiyonao  定 清直

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Researcher Number 10273765
Other IDs
  • ORCIDhttps://orcid.org/0000-0001-6124-3100
External Links
Affiliation (Current) 2025: 福井大学, 学術研究院医学系部門, 教授
Affiliation (based on the past Project Information) *help 2016 – 2023: 福井大学, 学術研究院医学系部門, 教授
2010 – 2015: 福井大学, 医学部, 教授
2006 – 2008: 福井大学, 医学部, 教授
2005: 神戸大学, 大学院医学系研究科, 助教授
2004 – 2005: 神戸大学, 大学院・医学系研究科, 助教授 … More
2001 – 2003: 神戸大学, 大学院・医学系研究科, 講師
1998: 神戸大, 医学部, 助手
1995 – 1998: Kobe University, School of Medicine Riserch Associate, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Pathological medical chemistry / General medical chemistry / Basic Section 49010:Pathological biochemistry-related / General medical chemistry / Functional biochemistry
Except Principal Investigator
Biological Sciences / Pathological medical chemistry / Pathological medical chemistry / Basic Section 48040:Medical biochemistry-related / Basic Section 49070:Immunology-related / Virology / General medical chemistry / General medical chemistry
Keywords
Principal Investigator
チロシンキナーゼ / C型肝炎ウイルス / 3BP2 / ゲノム編集 / 感染宿主因子 / プロテオーム解析 / シグナル伝達 / Syk / アダプター蛋白質 / 蛋白質チロシンリン酸化反応 … More / 蛋白質チロシンリン酸化酵素 / 細胞骨格 / 血小板 / Abl / HCV / ウイルス / アダプタータンパク質 / proteome analysis / Svk / signal transduction / virus-host relationship / protein-tyrosine kinase / protein-tvrosine phosphorylation / hepatitis C virus / ウイルス-宿主間相互作用 / 糖尿病 / 分子病態学 / Cb1-b / I型糖尿病 / cherubism / Cbl-b / ユビキチンリガーゼ / スキャッフォールド蛋白質 / 細胞内情報伝達機構 / GTP結合蛋白質 / G蛋白質 / 蛋白質チロシン燐酸化酵素 … More
Except Principal Investigator
Syk / チロシンキナーゼ / Lyn / 3BP2 / protein-tyrosine kinase / C型肝炎ウイルス / Shc / 細胞骨格 / lysosomes / phagocytosis / ubiquitination / Cbl / Pak2 / ZAP-70 / CD45 / DT-40 cell / DT40細胞 / SH2 / 感染症 / 血小板 / 血管内皮細胞 / 免疫応答 / NF-κB / チロシンリン酸化 / ユビキチン化 / NF-kappa B / MALT1 / CARD9 / C型レクチン受容体 / 抗ウイルス応答 / 自然免疫 / ストレス応答 / ウイルス感染 / 二重鎖RNA / ウイルス-宿主相互作用 / インターフェロン / Japan / Indonesia / hepatocellular carcinoma / carcinogenic risk / mutant / sequence variation / hepatitis C virus / hepatitis B virus / 原発性肝癌 / 発癌リスク / 日本 / インドネシア / 原発性肝がん / 発がんリスク / 変異株 / 遺伝子多様性 / B型肝炎ウイルス / Signal transduction / Tyrosine kinase / Infection / Cancer / 食作用 / CXCR4 / 発がん抑制 / 白血病 / 発がん / 補体 / ファゴサイトーシス / 生体分子 / シグナル伝達 / がん / ユビチキン・プロテアソーム / 酸化ストレス / 細胞接着 / 非受容体型チロシンキナーゼ / 蛋白質チロシンリン酸化反応 / 蛋白質リン酸化反応 / CRAM / c-Cbl / Cbl-b / アダプター蛋白質 / non-hematopoietic cells / tyrosine phosphorylated / neurons / smooth muscle cells / vascular endothelial cells / Protein-tyrosine / 神経成長円錐 / 平滑筋細胞 / 血管 / チロシン燐酸化 / 血管平滑筋細胞 / 神経系 / 肝臓細胞 / oxidative stress / cortactin / Zap-70 / TPA / K562細胞 / ホスホリパーゼD / 活性酸素 / 過酸化水素 / チロシンホスファターゼ / コルタクチン / mast cell / FcgammaRIIIA / IgE receptor / B cell receptor / Protein-tyrosine kinase / トロンビン / B細胞受容体 / IgE受容体 / p72syk / PLCγ / PI3キナーゼ / GAP / RBL-2H3細胞 / 遺伝子 / ウイルス / 細胞内輸送 / ELKS蛋白 / トランスアクチベーション / NS5A / p53癌抑制蛋白 / セリンプロテアーゼ / NS3 / HCVレプリコン / c-Ab1 / リソソーム / 微小管 / 巨核球 / 血小板生成 / 細胞移動 / 細胞増殖 / 癌 / small G蛋白質 / Src / Grb2 Less
  • Research Projects

    (23 results)
  • Research Products

    (111 results)
  • Co-Researchers

    (28 People)
  •  Regulation of anti-fungal immunity by adaptor protein 3BP2

    • Principal Investigator
      千原 一泰
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 48040:Medical biochemistry-related
    • Research Institution
      University of Fukui
  •  Regulatory mechanism of virus particle production by protein-tyrosine kinase Abl.Principal Investigator

    • Principal Investigator
      Sada Kiyonao
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49010:Pathological biochemistry-related
    • Research Institution
      University of Fukui
  •  Processing of double-stranded RNA during recovery of the cell from the double-stranded RNA stress

    • Principal Investigator
      Takeuchi Kenji
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49070:Immunology-related
    • Research Institution
      University of Fukui
  •  Novel function of tyrosine kinase Abl as a host factor against virus infectionPrincipal Investigator

    • Principal Investigator
      Kiyonao Sada
    • Project Period (FY)
      2017 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      University of Fukui
  •  Tyrosine phosphorylation of a viral protein in the hepatitis C virus life cycle

    • Principal Investigator
      Yamauchi Shota
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      University of Fukui
  •  Role of the regulation of B cell protein-tyrosine kinase by hepatitis C virusPrincipal Investigator

    • Principal Investigator
      SADA Kiyonao
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      University of Fukui
  •  Influence on protein-tyrosine phosphorylation by hepatitis C virus in B cellsPrincipal Investigator

    • Principal Investigator
      SADA Kiyonao
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      University of Fukui
  •  C型肝炎ウイルスの増殖適応変異と病原性の研究

    • Principal Investigator
      堀田 博
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kobe University
  •  Effects of hepatitis C virus proteins on protein-tyrosine phosphorylation in liver cellsPrincipal Investigator

    • Principal Investigator
      SADA Kiyonao
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      University of Fukui
  •  レプリコンを用いたC型肝炎ウイルス・宿主間相互作用の分子機序に関する研究

    • Principal Investigator
      HOTTA Hak
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kobe University
  •  スキャッフォールド蛋白質の新しい機能Principal Investigator

    • Principal Investigator
      定 清直
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General medical chemistry
    • Research Institution
      Kobe University
  •  Research of the novel role of Syk

    • Principal Investigator
      YAMAMURA Hirohei
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Kobe University
  •  Study on possible correlation between carcinogenic risk and genetic variation of hepatitis B and C viruses in Indonesia.

    • Principal Investigator
      HOTTA Hak
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Virology
    • Research Institution
      Kobe University
  •  血小板生成の謎に迫る-巨核球から血小板放出へ至る分子メカニズムの解明-

    • Principal Investigator
      山村 博平
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      General medical chemistry
    • Research Institution
      Kobe University
  •  Research for regulation system and new function of tyrosine kinase Syk

    • Principal Investigator
      YAMAMURA Hirohei
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General medical chemistry
    • Research Institution
      Kobe University
  •  細胞増殖およびがんの形成過程におけるチロシンキナーゼSykの機能解析

    • Principal Investigator
      山村 博平
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Kobe University
  •  血球系以外の組織におけるチロシンキナーゼSykの機能解析Principal Investigator

    • Principal Investigator
      定 清直
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Functional biochemistry
    • Research Institution
      Kobe University
  •  血液細胞におけるSykの生理的機能の解析;活性化機構と標的分子の同定Principal Investigator

    • Principal Investigator
      定 清直
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      General medical chemistry
    • Research Institution
      Kobe University
  •  IDENTIFICATION AND CHARACTERIZATION OF Syk FAMIRY PROTEIN TYROSINE KINASE

    • Principal Investigator
      YAMAMURA Hirohei
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      KOBE UNIVERSITY
  •  G蛋白質共役型受容体から蛋白質チロシン燐酸化酵素へのシグナル伝達機構の解析Principal Investigator

    • Principal Investigator
      定 清直
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      General medical chemistry
    • Research Institution
      Kobe University
  •  細胞質チロシンキナーゼp72^<syk>を介する細胞内情報伝達とG蛋白質

    • Principal Investigator
      YAMAMURA Hirohei
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kobe University
  •  Molecular basis of pathophysiological role of Syk in blood and immumecells

    • Principal Investigator
      YAMAMURA Hirohei
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      KOBE UNIVERSITY
  •  Physiological role of protein-tyrosine kinase p72^<syk>

    • Principal Investigator
      YAMAMURA Hirohei
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Kobe University
      福井医科大学

All 2023 2022 2021 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2008 2007 2006 2005 2004 Other

All Journal Article Presentation Book

  • [Book] C型レクチンによるマスト細胞の活性化メカニズム、臨床免疫・アレルギー科2018

    • Author(s)
      千原一泰,本定千知,木村幸弘,竹内健司,藤枝重治,石塚 全,定 清直
    • Total Pages
      5
    • Publisher
      科学評論社
    • Data Source
      KAKENHI-PROJECT-17K08656
  • [Journal Article] ケルビズム2023

    • Author(s)
      定 清直
    • Journal Title

      生化学

      Volume: 95 Pages: 117-117

    • Data Source
      KAKENHI-PROJECT-20K07354
  • [Journal Article] Novel roles of tyrosine kinase Abl as a host factor for microbial infection.2023

    • Author(s)
      定 清直、竹内 健司、千原 一泰
    • Journal Title

      生化学

      Volume: 95 Issue: 1 Pages: 96-99

    • DOI

      10.14952/SEIKAGAKU.2023.950096

    • ISSN
      0037-1017
    • Year and Date
      2023-02-25
    • Language
      Japanese
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K07354
  • [Journal Article] Adaptor protein 3BP2 regulates dectin-1-mediated cellular signalling to induce cytokine expression and NF-κB activation2022

    • Author(s)
      Chihara Kazuyasu、Chihara Yuri、Takeuchi Kenji、Sada Kiyonao
    • Journal Title

      Biochemical Journal

      Volume: 479 Issue: 4 Pages: 503-523

    • DOI

      10.1042/bcj20210707

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K07354
  • [Journal Article] Protein tyrosine kinase Abl promotes hepatitis C virus particle assembly via interaction with viral substrate activator NS5A2022

    • Author(s)
      Miyamoto Daisuke、Takeuchi Kenji、Chihara Kazuyasu、Fujieda Shigeharu、Sada Kiyonao
    • Journal Title

      Journal of Biological Chemistry

      Volume: 298 Issue: 4 Pages: 101804-101804

    • DOI

      10.1016/j.jbc.2022.101804

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K07354
  • [Journal Article] Evaluation of radiolabeled acetylcholine synthesis and release in rat striatum2021

    • Author(s)
      Muramatsu Ikunobu、Uwada Junsuke、Chihara Kazuyasu、Sada Kiyonao、Wang Mao‐Hsien、Yazawa Takashi、Taniguchi Takanobu、Ishibashi Takaharu、Masuoka Takayoshi
    • Journal Title

      Journal of Neurochemistry

      Volume: 160 Issue: 3 Pages: 342-355

    • DOI

      10.1111/jnc.15556

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07117, KAKENHI-PROJECT-19K09794, KAKENHI-PROJECT-20K07354, KAKENHI-PROJECT-20K09814
  • [Journal Article] Caspofungin suppresses zymosan-induced cytokine and chemokine release in THP-1 cells: possible involvement of the spleen tyrosine kinase pathway.2021

    • Author(s)
      Itoh K, Shigemi H, Chihara K, Sada K, Yamauchi T, Iwasaki H.
    • Journal Title

      Translational Research

      Volume: 227 Pages: 53-63

    • DOI

      10.1016/j.trsl.2020.07.005

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08656
  • [Journal Article] Store-operated calcium entry (SOCE) contributes to phosphorylation of p38 MAPK and suppression of TNF-α signalling in the intestinal epithelial cells.2019

    • Author(s)
      Uwada J, Yazawa T, Mikami D, Krug SM, Fromm M, Yoshiki H, Sada K, Muramatsu I, Taniguchi T.
    • Journal Title

      Cell signal.

      Volume: 63 Pages: 109358-109358

    • DOI

      10.1016/j.cellsig.2019.109358

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08656, KAKENHI-PROJECT-18K06946, KAKENHI-PROJECT-19K07117, KAKENHI-PROJECT-19K09794
  • [Journal Article] Novel regulatory systems for acetylcholine release in rat striatum and anti‐Alzheimer's disease drugs2019

    • Author(s)
      Muramatsu Ikunobu、Uwada Junsuke、Yoshiki Hatsumi、Sada Kiyonao、Lee Kung‐Shing、Yazawa Takashi、Taniguchi Takanobu、Nishio Matomo、Ishibashi Takaharu、Masuoka Takayoshi
    • Journal Title

      Journal of Neurochemistry

      Volume: 印刷中 Issue: 5 Pages: 605-623

    • DOI

      10.1111/jnc.14701

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K19012, KAKENHI-PROJECT-16K19023, KAKENHI-PROJECT-17K08656, KAKENHI-PROJECT-18K06946, KAKENHI-PROJECT-19K09794
  • [Journal Article] A New Aspect of Cholinergic Transmission in the Central Nervous System2018

    • Author(s)
      Muramatsu Ikunobu、Masuoka Takayoshi、Uwada Junsuke、Yoshiki Hatsumi、Yazama Takashi、Lee Kung-Shing、Sada Kiyonao、Nishio Matomo、Ishibashi Takaharu、Taniguchi Takanobu
    • Journal Title

      Nicotinic Acetylcholine Receptor Signaling in Neuroprotection

      Volume: 1 Pages: 45-58

    • DOI

      10.1007/978-981-10-8488-1_3

    • ISBN
      9789811084874, 9789811084881
    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08656, KAKENHI-PROJECT-16K19012
  • [Journal Article] Tubulointerstitial Nephritis with IgM-Positive Plasma Cells.2017

    • Author(s)
      Takahashi N, Kimura H et al
    • Journal Title

      J Am Soc Nephrol.

      Volume: 28 Issue: 12 Pages: 3688-3698

    • DOI

      10.1681/asn.2016101074

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K08931, KAKENHI-PROJECT-17K08656, KAKENHI-PROJECT-17K09692, KAKENHI-PROJECT-16K15232, KAKENHI-PROJECT-26293201, KAKENHI-PROJECT-15H04836, KAKENHI-PROJECT-16H05138, KAKENHI-PROJECT-16H05170, KAKENHI-PROJECT-15K09252
  • [Journal Article] Development of a multiplex real-time PCR assay for detection of human enteric viruses other than norovirus using samples collected from gastroenteritis patients in Fukui Prefecture, Japan2017

    • Author(s)
      Kowada Kazuaki、Takeuchi Kenji、Hirano Eiko、Toho Miho、Sada Kiyonao
    • Journal Title

      Journal of Medical Virology

      Volume: 90 Issue: 1 Pages: 67-75

    • DOI

      10.1002/jmv.24926

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08656
  • [Journal Article] Syk-dependent tyrosine phosphorylation of 3BP2 is required for optimal FcRγ-mediated phagocytosis and chemokine expression in U937 cells2017

    • Author(s)
      Chihara Kazuyasu、Kato Yuji、Yoshiki Hatsumi、Takeuchi Kenji、Fujieda Shigeharu、Sada Kiyonao
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 11480-11480

    • DOI

      10.1038/s41598-017-11915-5

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08656
  • [Journal Article] Regulation of synaptic acetylcholine concentrations by acetylcholine transport in rat striatal cholinergic transmission2017

    • Author(s)
      Muramatsu Ikunobu、Uwada Junsuke、Masuoka Takayoshi、Yoshiki Hatsumi、Sada Kiyonao、Lee Kung-Shing、Nishio Matomo、Ishibashi Takaharu、Taniguchi Takanobu
    • Journal Title

      Journal of Neurochemistry

      Volume: 143 Issue: 1 Pages: 76-86

    • DOI

      10.1111/jnc.14127

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08656, KAKENHI-PROJECT-16K19012, KAKENHI-PROJECT-16K19023, KAKENHI-PROJECT-15K08250
  • [Journal Article] Activation of muscarinic receptors prevents TNF-α-mediated intestinal epithelial barrier disruption through p38 MAPK2017

    • Author(s)
      Uwada Junsuke、Yazawa Takashi、Islam Md Tariqul、Khan Md Rafiqul Islam、Krug Susanne M.、Fromm Michael、Karaki Shin-ichiro、Suzuki Yuichi、Kuwahara Atsukazu、Yoshiki Hatsumi、Sada Kiyonao、Muramatsu Ikunobu、Taniguchi Takanobu
    • Journal Title

      Cellular Signalling

      Volume: 35 Pages: 188-196

    • DOI

      10.1016/j.cellsig.2017.04.007

    • NAID

      120006491645

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08656, KAKENHI-PROJECT-16K19012, KAKENHI-PROJECT-15K08182, KAKENHI-PROJECT-15K08250, KAKENHI-PROJECT-15K10654
  • [Journal Article] Association of C-Type Lectin Mincle with FcεRIβγ Subunits Leads to Functional Activation of RBL-2H3 Cells through Syk2017

    • Author(s)
      Honjoh Chisato、Chihara Kazuyasu、Yoshiki Hatsumi、Yamauchi Shota、Takeuchi Kenji、Kato Yuji、Hida Yukio、Ishizuka Tamotsu、Sada Kiyonao
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 46064-46064

    • DOI

      10.1038/srep46064

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08656, KAKENHI-PROJECT-15K09213
  • [Journal Article] STAT1 is essential for the inhibition of hepatitis C virus replication by interferon-lambda but not by interferon-alpha2016

    • Author(s)
      Yamauchi, S., Takeuchi, K., Chihara, K., Honjoh, C., Kato, Y., Yoshiki, H., Hotta, H., and Sada, K.
    • Journal Title

      Sci. Rep.

      Volume: 6 Issue: 1 Pages: 38336-38336

    • DOI

      10.1038/srep38336

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K19021
  • [Journal Article] Hepatitis C virus particle assembly involves phosphorylation of NS5A by the c-Abl tyrosine kinase2015

    • Author(s)
      Yamauchi, S., Takeuchi, K., Chihara, K., Sun, X., Honjoh, C., Yoshiki, H., Hotta, H., and Sada, K.
    • Journal Title

      J. Biol. Chem.

      Volume: 290 Issue: 36 Pages: 21857-21864

    • DOI

      10.1074/jbc.m115.666859

    • NAID

      120005973616

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K19021, KAKENHI-PROJECT-25460383
  • [Journal Article] Tyrosine phosphorylation of 3BP2 is indispensable for the interaction with Vav3 in chicken DT40 cells2014

    • Author(s)
      Chihara, K., Kimura, Y., Honjoh, C., Yamauchi, S., Takeuchi, K., Sada, K.
    • Journal Title

      Exp. Cell Res.

      Volume: 322 Issue: 1 Pages: 99-107

    • DOI

      10.1016/j.yexcr.2013.12.026

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591105, KAKENHI-PROJECT-25460383
  • [Journal Article] 関最新節リウマチ学 ―寛解・治癒を目指した研究と最新治療― Syk阻害薬2014

    • Author(s)
      本定千知、千原一泰、木村幸弘、竹内健司、定 清直
    • Journal Title

      日本臨牀増刊号「最新関節リウマチ学─寛解・治癒を目指した研究と最新治療」

      Volume: なし Pages: 521-524

    • Data Source
      KAKENHI-PROJECT-25460383
  • [Journal Article] Dectin-1-mediated signaling leads to characteristic gene expressions and cytokine secretion via spleen tyrosine kinase (Syk) in rat mast cells.2014

    • Author(s)
      Kimura Y, Chihara K, Honjoh C, Takeuchi K, Yamauchi S, Yoshiki H, Fujieda S, Sada K
    • Journal Title

      J Biol Chem.

      Volume: 289 Issue: 45 Pages: 31565-75

    • DOI

      10.1074/jbc.m114.581322

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25293348, KAKENHI-PROJECT-25460383, KAKENHI-PROJECT-26293368
  • [Journal Article] Syk inhibitors2013

    • Author(s)
      千原一泰、木村幸弘、本定千知、竹内健司、定 清直
    • Journal Title

      Japanese Journal of Clinical Immunology

      Volume: 36 Issue: 4 Pages: 197-202

    • DOI

      10.2177/jsci.36.197

    • NAID

      10031196416

    • ISSN
      0911-4300, 1349-7413
    • Language
      Japanese
    • Data Source
      KAKENHI-PROJECT-25460383
  • [Journal Article] 関節リウマチ ケアからキュアを目指した治療:Syk 阻害薬2013

    • Author(s)
      木村幸弘、千原一泰、竹内健司、定 清直
    • Journal Title

      日本臨牀

      Volume: 71(7) Pages: 1248-1252

    • Data Source
      KAKENHI-PROJECT-25460383
  • [Journal Article] Syk 阻害薬-チロシンキナーゼSykの基礎と臨床-. 炎症疾患におけるキナーゼ阻害薬の進歩2012

    • Author(s)
      定 清直
    • Journal Title

      医学のあゆみ

      Volume: 240(7) Pages: 567-570

    • Data Source
      KAKENHI-PROJECT-22590285
  • [Journal Article] Syk阻害薬.2012

    • Author(s)
      定 清直
    • Journal Title

      医薬ジャーナル

      Volume: 48(6) Pages: 1531-1534

    • NAID

      120005463375

    • Data Source
      KAKENHI-PROJECT-22590285
  • [Journal Article] Syk阻害薬-チロシンキナーゼSykの基礎と臨床-.炎症疾患におけるキナーゼ阻害薬の進歩2012

    • Author(s)
      定清直
    • Journal Title

      医学のあゆみ

      Volume: 240(7) Pages: 567-570

    • Data Source
      KAKENHI-PROJECT-22590285
  • [Journal Article] Spleen tyrosine kinase (Syk)の生理的役割とその阻害薬の作用2012

    • Author(s)
      千原一泰, 中島謙治, 竹内健司, 定 清直
    • Journal Title

      リウマチ科

      Volume: 47(6) Pages: 694-699

    • Data Source
      KAKENHI-PROJECT-22590285
  • [Journal Article] 次世代低分子化合物:Syk 阻害薬. 特集 関節リウマチの最新情報-寛解を目指した診断と治療の新展開-2012

    • Author(s)
      中島謙治, 千原一泰, 竹内健司, 定 清直
    • Journal Title

      最新医学

      Volume: 67(2) Pages: 101-106

    • Data Source
      KAKENHI-PROJECT-22590285
  • [Journal Article] Syk 阻害薬. 特集 リウマチ治療薬の新展開2012

    • Author(s)
      定 清直
    • Journal Title

      医薬ジャーナル

      Volume: 48(6) Pages: 1531-1534

    • NAID

      40019349577

    • Data Source
      KAKENHI-PROJECT-22590285
  • [Journal Article] HCV NS5A protein containing potential ligands for both Src homology 2 and 3 domains enhances autophosphorylation of Src family kinase Fyn in B cells2012

    • Author(s)
      Nakashima, K., Takeuchi, K., Chihara, K., Horiguchi, T., Sun, X., Deng, L., Shoji, I., Hotta, H., and Sada, K
    • Journal Title

      PLoS ONE

      Volume: 7(10)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590285
  • [Journal Article] Association of 3BP2 with SHP-1 regulates SHP-1-mediated production of TNF-α in RBL-2H3 cells2011

    • Author(s)
      Chihara, K., Nakashima, K., Takeuchi, K., and Sada, K
    • Journal Title

      Genes Cells

      Volume: 16(12) Pages: 1133-1145

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590285
  • [Journal Article] Enhancement of B cell receptor signaling by a point mutation of adaptor protein 3BP2 identified in human inherited disease cherubism2011

    • Author(s)
      Ogi, K., Nakashima, K., Chihara, K., Takeuchi, K., Horiguchi, T., Fujieda, S., and Sada, K
    • Journal Title

      Genes Cells

      Volume: 16(9) Pages: 951-960

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590285
  • [Journal Article] Inhibitory effect of Acai (Euterpe oleracea Mart.) pulp on IgE-mediated mast cell activation2011

    • Author(s)
      Horiguchi, T., Ishiguro, N., Chihara, K., Ogi, K., Nakashima, K., Sada, K., and Hori-Tamura, N
    • Journal Title

      J. Agric. Food. Chem

      Volume: 59(10) Pages: 5595-5601

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590285
  • [Journal Article] Inhibition of hepatitis C virus replication through AMP-activated protein kinase-dependent and independent pathways2011

    • Author(s)
      Nakashima, K., Takeuchi, K., Chihara, K., Hotta, H., and Sada, K
    • Journal Title

      Microbiol. Immunol

      Volume: 55(11) Pages: 774-782

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590285
  • [Journal Article] C 型肝炎ウイルスの病原性発現 機 構2010

    • Author(s)
      定 清直
    • Journal Title

      小児感染免疫

      Volume: 22(1) Pages: 35-41

    • NAID

      10026419798

    • Data Source
      KAKENHI-PROJECT-22590285
  • [Journal Article] 関節リウマチ治療におけるSyk阻害薬の可能性を探る. 特集 次世代の低分子量化合物は生物学的製剤を超えることができるか2010

    • Author(s)
      千原一泰, 定 清直
    • Journal Title

      分子リウマチ治療

      Volume: 3(4) Pages: 186-189

    • NAID

      40017367198

    • Data Source
      KAKENHI-PROJECT-22590285
  • [Journal Article] C型肝炎ウイルスの病原性発現機構2010

    • Author(s)
      定清直
    • Journal Title

      小児感染免疫

      Volume: 22(1) Pages: 35-41

    • NAID

      10026419798

    • Data Source
      KAKENHI-PROJECT-22590285
  • [Journal Article] Adaptor protein 3BP2 and cherubism2008

    • Author(s)
      Hatani, T., Sada, K
    • Journal Title

      Curr. Med. Chem 15(6)

      Pages: 549-554

    • NAID

      120000807824

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590293
  • [Journal Article] Single-point mutations of hepatitis C virus NS3 that impair p53 interaction and anti-apoptotic activity of NS32006

    • Author(s)
      Tanaka, M., Nagano-Fujii, M., Deng, L., Ishido, S., Sada, K., Hotta, H
    • Journal Title

      Biochem. Biophys. Res. Commun 340(3)

      Pages: 792-799

    • NAID

      120000943971

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590293
  • [Journal Article] The NS3 protein of hepatitis C virus associates with the tumor suppressor p53 and inhibits its function in an NS3 sequence-dependent manner2006

    • Author(s)
      Deng, L., Nagano-Fujii, M., Tanaka, M., Nomura-Takigawa, Y., Ikeda, M., Kato, N., Sada. K., Hotta, H
    • Journal Title

      J. Gen. Virol 87(6)

      Pages: 1703-1713

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590293
  • [Journal Article] A novel mitochondria ubiquitin ligase plays a critical role in mitochondria] dynamics2006

    • Author(s)
      Yonashiro, R., Ishido, S., Kyo, S., Fukuda, T., Goto, E., Matsuki, Y., Ohmura-Hashimoto, M., Sada. K., Hotta, H., Yamamura, H., Inatome, R., Yanagi, S
    • Journal Title

      EMBO J 25(15)

      Pages: 3618-3626

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590293
  • [Journal Article] Inhibition of measles virus and subacute sclerosing panencephalitis virus by RNA interference2006

    • Author(s)
      Otaki, M., Sada, K., Kadoya, H., Nagano-Fujii, M., Hotta, H
    • Journal Title

      Antiviral Res 70(3)

      Pages: 105-111

    • NAID

      120000945629

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590293
  • [Journal Article] The nonstructural protein 4A of hepatitis C virus accumulates on mitochondria and induces apoptotic cell death through a mitochondria-mediated pathway2006

    • Author(s)
      Nomura-Takigawa, Y., Nagano-Fujii, M., Deng, L., Kitazawa, S., Ishido, S., Sada, K., Hotta, H
    • Journal Title

      J. Gen. Virol 87(7)

      Pages: 1935-1945

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590293
  • [Journal Article] Full-length sequence analysis of subacute sclerosing panencephalitis (SSPE) virus, a mutant of measles virus, isolated from brain tissues of a patient shortly after onset of SSPE2006

    • Author(s)
      Hotta, H., Nihei, K., Abe, Y., Kato, S., Jiang D. P., Nagano-Fujii, M., Sada, K
    • Journal Title

      Microbiol. Immunol 50(7)

      Pages: 525-534

    • NAID

      10017991849

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590293
  • [Journal Article] 肥満細胞におけるFcεレセプターIからのシグナル伝達:3BP2とCbl-bによる肥満細胞活性化制御2005

    • Author(s)
      定 清直
    • Journal Title

      臨床免疫 44(1)

      Pages: 63-70

    • Data Source
      KAKENHI-PROJECT-16790170
  • [Journal Article] マスト細胞活性化シグナルを制御する分子.特集 マスト細胞とアレルギー.2005

    • Author(s)
      定 清直
    • Journal Title

      Molecular Medicine 42(10)

      Pages: 1107-1112

    • Data Source
      KAKENHI-PROJECT-16790170
  • [Journal Article] Activation of Syk protein tyrosine kinase in response to osmotic stress requires interaction with p21-activated protein kinase Pak2γ-PAK.2004

    • Author(s)
      Miah, S.M.S., Sada, K., Tuazon, P.T., Ling, J., Maeno, K., Kyo, S., Qu, X., Tohyama, Y., Traugh, J.A., Yamamura, H.
    • Journal Title

      Mol.Cell.Biol. 24

      Pages: 71-83

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390095
  • [Journal Article] マスト細胞学の分子生物学-IgEシグナルを中心に-2004

    • Author(s)
      定 清直
    • Journal Title

      アレルギーの臨床 24・10

      Pages: 781-785

    • Data Source
      KAKENHI-PROJECT-16790170
  • [Journal Article] マスト細胞の負の活性制御因子2004

    • Author(s)
      定 清直
    • Journal Title

      アレルギー科 17・3

      Pages: 220-227

    • Data Source
      KAKENHI-PROJECT-16790170
  • [Journal Article] Hepatitis C virus NS5A protein interacts with and negatively regulates the non-receptor protein-tyrosine kinase Syk

    • Author(s)
      Inubushi, S., Nagano-Fujii, M., Kitayama, K., Tanaka, M., An, C., Yokozaki, H., Yamamura, H., Nuriya, H., Kohara, M., Sada, K., Hotta, H
    • Journal Title

      J. Gen. Virol (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590293
  • [Presentation] アダプター蛋白質3BP2によるCARD9の機能調節機構の解析2023

    • Author(s)
      坪川亜優美、千原一泰、千原悠里、竹内健司、藤枝重治、定清直
    • Organizer
      日本生化学会北陸支部第41回大会
    • Data Source
      KAKENHI-PROJECT-22K06897
  • [Presentation] アダプター蛋白質3BP2によるCARD9シグナル伝達機構の調節2023

    • Author(s)
      坪川亜優美、千原一泰、千原悠里、竹内健司、藤枝重治、定清直
    • Organizer
      第96回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-22K06897
  • [Presentation] アダプター蛋白質3BP2はC型レクチン受容体dectin-1を介するサイトカインの産生とNF-κBの活性化を制御する2022

    • Author(s)
      千原一泰, 坪川亜優美, 千原悠里, 竹内健司, 藤枝重治, 定 清直
    • Organizer
      第45回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-22K06897
  • [Presentation] ウイルス感染・免疫応答を制御する宿主因子の新しい役割Ⅲ2022

    • Author(s)
      定 清直
    • Organizer
      2022年度北陸腸内細菌研究会・研究発表会
    • Data Source
      KAKENHI-PROJECT-20K07354
  • [Presentation] チロシンキナーゼAblはウイルス基質活性化因子NS5Aとの相互作用によりC型肝炎ウイルス粒子形成を促進する2022

    • Author(s)
      宮本大輔, 竹内健司, 千原一泰, 藤枝重治, 定 清直
    • Organizer
      第95回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-22K06897
  • [Presentation] 福井大学における感染症医療人材養成事業(UF-IDEEP)と特色あるカリキュラム「感染症」の新設2022

    • Author(s)
      定 清直, 酒巻一平, 岩﨑博道
    • Organizer
      第65回日本感染症学会中日本地方会学術集会
    • Data Source
      KAKENHI-PROJECT-20K07354
  • [Presentation] チロシンキナーゼAblはウイルス基質活性化因子NS5Aとの相互作用によりC型肝炎ウイルス粒子形成を促進する2022

    • Author(s)
      宮本大輔, 竹内健司, 千原一泰, 藤枝重治, 定 清直
    • Organizer
      第95回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-20K07354
  • [Presentation] アダプター蛋白質3BP2はC型レクチン受容体dectin-1を介するサイトカインの産生とNF-κBの活性化を制御する2022

    • Author(s)
      千原一泰, 坪川亜優美, 千原悠里, 竹内健司, 藤枝重治, 定 清直
    • Organizer
      第45回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-20K07354
  • [Presentation] Covid-19 epidemic in Fukui Prefecture2021

    • Author(s)
      Hasegawa T, Sada, K., and Hasegawa M.
    • Organizer
      UNAIR The 12th International Nursing Conference “Reframing Nursing Education, Research and Practice: COVID-19 as Catalyst for Innovation”
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K07354
  • [Presentation] アダプター蛋白質3BP2はC型レクチンDectin-1を介するサイトカインの産生とNF-κBの活性化を制御する2021

    • Author(s)
      千原一泰,千原悠里,竹内健司,定 清直
    • Organizer
      第94回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-20K07354
  • [Presentation] 感染症教育と国際交流2021

    • Author(s)
      定 清直
    • Organizer
      第128回関西形成外科学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K07354
  • [Presentation] 感染免疫を制御する宿主因子の新しい役割:チロシンキナーゼAblとSyk2019

    • Author(s)
      定 清直.
    • Organizer
      高分子学会 バイオ・高分子研究会
    • Data Source
      KAKENHI-PROJECT-17K08656
  • [Presentation] 非受容体型チロシンキナーゼAblとC型肝炎ウイルスの相互作用2019

    • Author(s)
      宮本大輔,竹内健司,千原一泰,定 清直
    • Organizer
      第42回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-17K08656
  • [Presentation] ゲノム編集マウスを利用したB細胞におけるアダプタータンパク質3BP2の機能解析2018

    • Author(s)
      千原一泰, 竹内健司, 千原悠里, 宮本大輔, 定 清直
    • Organizer
      第91回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-17K08656
  • [Presentation] Syk阻害薬:基礎的背景と病態への展望2018

    • Author(s)
      定 清直
    • Organizer
      第61回日本腎臓学会学術総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K08656
  • [Presentation] アダプター蛋白質3BP2による貪食細胞の機能調節メカニズム2017

    • Author(s)
      千原一泰, 加藤雄士, 竹内健司, 藤枝重治, 定 清直
    • Organizer
      日本生化学会北陸支部第35回大会
    • Data Source
      KAKENHI-PROJECT-17K08656
  • [Presentation] マスト細胞におけるC型レクチンMincleの機能解析2015

    • Author(s)
      本定千知, 千原一泰, 吉木はつみ, 山内翔太, 竹内健司, 飛田征男, 岩野正之, 石塚全, 定清直
    • Organizer
      BMB2015
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-02
    • Data Source
      KAKENHI-PROJECT-25460383
  • [Presentation] Role of c-Abl in hepatitis C virus particle assembly2015

    • Author(s)
      Yamauchi, S., Takeuchi, K., Chihara, K., Sun, X., Honjoh, C., Yoshiki, H., Hotta, H., and Sada, K.
    • Organizer
      第38回日本分子生物学会年会・第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-02
    • Data Source
      KAKENHI-PROJECT-15K19021
  • [Presentation] C型肝炎ウイルス粒子形成におけるc-Ablの役割2015

    • Author(s)
      山内翔太, 竹内健司, 千原一泰, 孫雪東, 本定千知, 吉木はつみ, 堀田博, 定清直
    • Organizer
      BMB2015
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-03
    • Data Source
      KAKENHI-PROJECT-25460383
  • [Presentation] マスト細胞におけるC型レクチンMincleの機能解析2015

    • Author(s)
      本定千知, 千原一泰, 吉木はつみ, 山内翔太, 竹内健司, 飛田征男, 岩野正之, 石塚全, 定清直
    • Organizer
      日本生化学会北陸支部第33回大会
    • Place of Presentation
      富山
    • Year and Date
      2015-05-23
    • Data Source
      KAKENHI-PROJECT-25460383
  • [Presentation] チロシンキナーゼによるHCV複製の制御機構2015

    • Author(s)
      山内翔太, 竹内健司, 千原一泰, 孫雪東, 本定千知, 吉木はつみ, 堀田博, 定清直
    • Organizer
      日本生化学会北陸支部第33回大会, シンポジウム「病原性ウイルス・免疫応答研究の最前線」
    • Place of Presentation
      富山
    • Year and Date
      2015-05-23
    • Invited
    • Data Source
      KAKENHI-PROJECT-25460383
  • [Presentation] Role of NS5A tyrosine phosphorylation in hepatitis C virus particle assembly2015

    • Author(s)
      Yamauchi, S., Takeuchi, K., Chihara, K., Sun, X., Honjoh, C., Yoshiki, H., Hotta, H., and Sada, K.
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-23
    • Data Source
      KAKENHI-PROJECT-15K19021
  • [Presentation] アダプター蛋白質3BP2は分化したAML細胞においてSrc型チロシンキナーゼの活性化を促進する2015

    • Author(s)
      千原一泰,吉木はつみ,加藤雄士,本定千知,山内翔太,竹内健司,定清直
    • Organizer
      BMB2015
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-03
    • Data Source
      KAKENHI-PROJECT-25460383
  • [Presentation] マスト細胞におけるDectin-1の機能解析:真菌感染防御におけるマスト細胞の新たな役割.2014

    • Author(s)
      千原一泰,木村幸弘,本定千知,吉木はつみ,山内翔太,竹内健司,定 清直.
    • Organizer
      日本生化学会北陸支部第32回大会
    • Place of Presentation
      富山大学杉谷キャンパス
    • Year and Date
      2014-05-24
    • Data Source
      KAKENHI-PROJECT-25460383
  • [Presentation] Syk阻害薬2013

    • Author(s)
      定 清直
    • Organizer
      第57回日本リウマチ学会・学術集会
    • Place of Presentation
      国立京都国際会館
    • Invited
    • Data Source
      KAKENHI-PROJECT-25460383
  • [Presentation] C型レクチンDectin-1を介するマスト細胞の活性化機構2013

    • Author(s)
      木村幸弘, 千原一泰, 竹内 健司, 本定千知, 藤枝重治, 定 清直
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Data Source
      KAKENHI-PROJECT-25460383
  • [Presentation] C型肝炎ウイルス非構造蛋白質NS5AにおけるFyn-SH2ドメインとの結合に重要なチロシン残基同定の試み2013

    • Author(s)
      竹内健司, 孫 雪東, 千原一泰, Lin Deng, 勝二郁夫, 堀田 博, 定 清直
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸国際会議場
    • Data Source
      KAKENHI-PROJECT-25460383
  • [Presentation] ニワトリDT40細胞におけるアダプター蛋白質3BP2のチロシンリン酸化とVav3との会合メカニズム2013

    • Author(s)
      千原一泰, 木村幸弘, 本定千知, 竹内 健司, 定 清直
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Data Source
      KAKENHI-PROJECT-25460383
  • [Presentation] Syk 標的治療2012

    • Author(s)
      定 清直
    • Organizer
      第40回日本臨床免疫学会
    • Place of Presentation
      東京
    • Year and Date
      2012-09-27
    • Data Source
      KAKENHI-PROJECT-22590285
  • [Presentation] 第60回日本ウイルス学会学術集会2012

    • Author(s)
      定 清直
    • Organizer
      C型肝炎ウイルスNS5AはB細胞のチロシンキナーゼFynを活性化する.
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-22590285
  • [Presentation] HCV NS5A protein containing potential ligands for both Src homology 2 and 3 domains enhances autophosphorylation of Src family kinase Fyn in B cells2012

    • Author(s)
      Nakashima, K., Takeuchi, K., Chihara, K., Horiguchi, T., Sun, X., Deng, L., Shoji, I., Hotta, H., and Sada, K
    • Organizer
      IUBMB&FEBS
    • Place of Presentation
      Sevilla, Spain
    • Year and Date
      2012-09-06
    • Data Source
      KAKENHI-PROJECT-22590285
  • [Presentation] C 型肝炎ウイルス研究の今日的話題2012

    • Author(s)
      定 清直
    • Organizer
      第2回医学教育アフリカ支援国際セミナー
    • Place of Presentation
      福井
    • Year and Date
      2012-03-17
    • Data Source
      KAKENHI-PROJECT-22590285
  • [Presentation] 第35回日本分子生物学会年会2012

    • Author(s)
      定 清直
    • Organizer
      C型肝炎ウイルスNS5A蛋白質のSrc homology 2/3ドメイン結合能とB細胞での発現によるSrcファミリーキナーゼFynの活性化.
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-22590285
  • [Presentation] C型肝炎ウイルスNS5A蛋白質のSrc homology 2/3ドメイン結合能とB細胞での発現によるSrcファミリーキナーゼFynの活性化2012

    • Author(s)
      中島謙治, 竹内 健司, 千原一泰, 堀口朋子, 孫雪東, Lin Deng, 勝二郁夫, 堀田 博, 定 清直
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-11
    • Data Source
      KAKENHI-PROJECT-22590285
  • [Presentation] HCV NS5A protein containing potential ligands for both Src homology 2 and 3 domains enhances autophosphorylation of Src family kinase Fyn in B cells.2012

    • Author(s)
      Sada, K.
    • Organizer
      IUBMB&FEBS
    • Place of Presentation
      Sevilla, Spain
    • Data Source
      KAKENHI-PROJECT-22590285
  • [Presentation] C型肝炎ウイルス研究の今日的話題2012

    • Author(s)
      定清直
    • Organizer
      第2回医学教育アフリカ支援国際セミナー
    • Place of Presentation
      福井(招待講演)
    • Year and Date
      2012-03-17
    • Data Source
      KAKENHI-PROJECT-22590285
  • [Presentation] Syk標的治療.2012

    • Author(s)
      定 清直
    • Organizer
      第40回日本臨床免疫学会
    • Place of Presentation
      東京
    • Invited
    • Data Source
      KAKENHI-PROJECT-22590285
  • [Presentation] Syk阻害薬.2012

    • Author(s)
      定 清直
    • Organizer
      第56回日本リウマチ学会総会・学術集会
    • Place of Presentation
      東京
    • Invited
    • Data Source
      KAKENHI-PROJECT-22590285
  • [Presentation] Syk 阻害薬. SLE の新規治療2012

    • Author(s)
      定 清直
    • Organizer
      第56回日本リウマチ学会総会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      2012-04-27
    • Data Source
      KAKENHI-PROJECT-22590285
  • [Presentation] C型肝炎ウイルスNS5AはB細胞のチロシンキナーゼFynを活性化する2012

    • Author(s)
      中島謙治, 竹内健司, 千原一泰, 堀口朋子, 孫 雪東, Lin Deng, 勝二郁夫, 堀田 博, 定 清直
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2012-11-14
    • Data Source
      KAKENHI-PROJECT-22590285
  • [Presentation] 次世代低分子化合物を用いた治療-Syk 阻害薬-2011

    • Author(s)
      定 清直
    • Organizer
      第55回日本リウマチ学会総会・学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2011-07-19
    • Data Source
      KAKENHI-PROJECT-22590285
  • [Presentation] Inhibition of hepatitis C virus replication through AMP-activated protein kinase-dependent and independent pathways2011

    • Author(s)
      Nakashima, K., Takeuchi, K., Chihara, K., Hotta, H., and Sada, K
    • Organizer
      IUMS 2011
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      2011-09-15
    • Data Source
      KAKENHI-PROJECT-22590285
  • [Presentation] Sykの基礎と臨床新しい標的分子と疾患制御2011

    • Author(s)
      定清直
    • Organizer
      第39回日本臨床免疫学会総会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2011-09-15
    • Data Source
      KAKENHI-PROJECT-22590285
  • [Presentation] Tyrosine phosphorylation of 3BP2 regulates BCR-mediated activation of NFAT2011

    • Author(s)
      Sada, K.
    • Organizer
      Immunology 2011
    • Place of Presentation
      San Francisco
    • Year and Date
      2011-05-15
    • Data Source
      KAKENHI-PROJECT-22590285
  • [Presentation] C 型肝炎ウイルス複製におけるエネルギーセンサーAMPKの役割2011

    • Author(s)
      中島謙治, 竹内健司, 千原一泰, 堀田博, 定 清直
    • Organizer
      日本生化学会北陸支部第29回大会
    • Place of Presentation
      金沢
    • Year and Date
      2011-05-28
    • Data Source
      KAKENHI-PROJECT-22590285
  • [Presentation] 次世代低分子化合物を用いた治療-Syk阻害薬-.Next Decade Symposium 3「新しい病因・病態・治療法を探る-あらたな関節リウマチ治療標的分子-」2011

    • Author(s)
      定清直
    • Organizer
      第55回日本リウマチ学会総会・学術集会
    • Place of Presentation
      神戸(招待講演)
    • Year and Date
      2011-07-19
    • Data Source
      KAKENHI-PROJECT-22590285
  • [Presentation] Tyrosine phosphorylation of 3BP2 regulates BCR-mediated activation of NFAT2011

    • Author(s)
      Sada, K., Nakashima, K., Ogi, K., and Chihara, K
    • Organizer
      Immunology 2011
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2011-05-15
    • Data Source
      KAKENHI-PROJECT-22590285
  • [Presentation] Association of 3BP2 with SHP-1 regulates SHP-1-mediated production of TNF- in RBL-2H3 cells2011

    • Author(s)
      千原一泰, 中島謙治, 竹内健司, 定 清 直
    • Organizer
      第34回日本分子生物学会年会(MBSJ2011)
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-16
    • Data Source
      KAKENHI-PROJECT-22590285
  • [Presentation] Syk の基礎と臨床新しい標的分子と疾患制御2011

    • Author(s)
      定 清直
    • Organizer
      第39回日本臨床免疫学会総会(免疫疾患学会連合2011)
    • Place of Presentation
      東京
    • Year and Date
      2011-09-15
    • Data Source
      KAKENHI-PROJECT-22590285
  • [Presentation] C 型肝炎ウイルスの病原性発現機構2010

    • Author(s)
      定 清直
    • Organizer
      第84回日本感染症学会総会
    • Place of Presentation
      京都
    • Year and Date
      2010-04-05
    • Data Source
      KAKENHI-PROJECT-22590285
  • [Presentation] エネルギーセンサーAMPKの活性化によるC型肝炎ウイルス複製の抑制2010

    • Author(s)
      中島謙治, 竹内健司, 千原一泰, 堀田 博, 定 清直
    • Organizer
      第58回日本ウイルス学会学術集会
    • Place of Presentation
      徳島
    • Year and Date
      2010-11-07
    • Data Source
      KAKENHI-PROJECT-22590285
  • [Presentation] アダプタータンパク質の点突然変異によるB細胞シグナル伝達の増強2010

    • Author(s)
      扇 和弘, 羽溪朋子, 中島謙治, Upasana Shukla, 千原一泰, 藤枝重治, 定 清直
    • Organizer
      日本生化学会北陸支部第28回大会
    • Place of Presentation
      福井
    • Year and Date
      2010-05-29
    • Data Source
      KAKENHI-PROJECT-22590285
  • [Presentation] ハスカップ果実によるマスト細胞の脱顆粒抑制機構の解析2010

    • Author(s)
      石黒奈穂子, 堀口朋子, 福本菜奈子, 定 清直, 田村(堀)奈緒子
    • Organizer
      BMB2010
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-07
    • Data Source
      KAKENHI-PROJECT-22590285
  • [Presentation] アダプタータンパク質の点突然変異によるB細胞シグナル伝達への影響2010

    • Author(s)
      扇 和弘, 中島謙治, シュクラウパサナ, 千原一泰, 藤枝重治, 定 清直
    • Organizer
      BMB2010
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-08
    • Data Source
      KAKENHI-PROJECT-22590285
  • [Presentation] エネルギーセンサーAMPKの活性化によるC型肝炎ウイルス複製の抑制2010

    • Author(s)
      中島謙治, 竹内健司, 千原一泰, 堀田 博, 定 清直
    • Organizer
      BMB2010
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-07
    • Data Source
      KAKENHI-PROJECT-22590285
  • [Presentation] C型肝炎ウイルスの病原性発現機構2010

    • Author(s)
      定清直
    • Organizer
      第84回日本感染症学会総会
    • Place of Presentation
      京都 招待講演
    • Year and Date
      2010-04-05
    • Data Source
      KAKENHI-PROJECT-22590285
  • [Presentation] Syk阻害剤2010

    • Author(s)
      定清直
    • Organizer
      第54回日本リウマチ学会総会
    • Place of Presentation
      神戸 招待講演
    • Year and Date
      2010-04-24
    • Data Source
      KAKENHI-PROJECT-22590285
  • [Presentation] Syk 阻害剤2010

    • Author(s)
      定 清直
    • Organizer
      第54回日本リウマチ学会総会・学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2010-04-24
    • Data Source
      KAKENHI-PROJECT-22590285
  • [Presentation] Glucose uptake and GLUTI/2 expression are down -regulated in Huh-7.5 cells harboring an HCV subgenomic RNA replicon and full-genomic RNA replicon2007

    • Author(s)
      Kasai, D., Nagano-Fujii, M., Bungyoku, Y., Sasayama, M., Sada. K., Hotta, H
    • Organizer
      14th International Symposium on Hepatitis Virus and Related Viruses
    • Place of Presentation
      Glasgow, UK
    • Year and Date
      2007-09-10
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590293
  • [Presentation] Kinase activity of the non-receptor tyrosine kinase Syk is down-regulated in Huh-7.5 cells harboring an HCV RNA subgenomic replicon2006

    • Author(s)
      Inubushi, S., Nagano-Fujii, M., Kitayama, K., Yamamura, H., Sada, K., Hotta, H
    • Organizer
      13th International Symposium on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2006-08-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590293
  • [Presentation] A high degree of sequence variation of HCV NS5A and the presence of anti-NS5A antibodies in the pretreatment sera are associated with efficient viral clearance by combination therapy using pegylated interferon and ribavirin2006

    • Author(s)
      El-Shamy, A., Sasayama, M., Nagano-Fujii, M., Sada, K., Kim, S. R., Hotta, H
    • Organizer
      13th International Symposium on Hepatitis C Virus and Related Viruses
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2006-08-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590293
  • 1.  YAMAMURA Hirohei (90030882)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 1 results
  • 2.  HOTTA Hak (40116249)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 26 results
  • 3.  CHIHARA Kazuyasu (00314948)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 50 results
  • 4.  TAKEUCHI Kenji (40236419)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 46 results
  • 5.  YANAGI Shigeru (60252003)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 6.  NAGANO Motoko (90304089)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 7.  TOHYAMA Yumi (70362770)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 8.  TAKANO Tomoko (30226807)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  YAMAUCHI Shota (00728941)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 10 results
  • 10.  MINAMI Yasuhiro (70229772)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  扇本 真治 (80292853)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  YAMAMOTO Tadashi (40134621)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  HATANI Tomoko (60452124)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 14.  勝二 郁夫 (40356241)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  足達 哲也 (60345014)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  竹内 郁登 (70262623)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  丸山 晋吾 (90262633)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  稲津 哲也 (00242587)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  谷口 隆信 (60217130)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 20.  KUROSAKI Tomohiro
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  KINET Jean-pierre
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  TOMOHIRO Kur
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  UWADA Junsuke
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 24.  木村 秀樹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 25.  乙葉 基子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 9 results
  • 26.  矢澤 隆志
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 27.  益岡 尚由
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 28.  藤枝 重治
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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