OKAYASU MARI 岡安麻里

… Alternative Names

OKAYASU Mari 岡安麻里

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Researcher Number	10610941
Affiliation (Current)	2025: 東京大学, 医学部附属病院, 病院診療医(出向)
Affiliation (based on the past Project Information) *help	2022 – 2023: 東京大学, 医学部附属病院, 病院診療医(出向) 2016 – 2021: 東京大学, 医学部附属病院, 助教 2015: 東京大学, 医学部付属病院, 特任臨床医 2013 – 2015: 東京大学, 医学部附属病院, 特任臨床医 2012 – 2015: 東京大学, 医学部附属病院, その他 2011: 東京大学, 医学部附属病院, 特任臨床医
Review Section/Research Field	Principal Investigator Basic Section 57070:Developmental dentistry-related / Surgical dentistry / Orthodontic/Pediatric dentistry Except Principal Investigator Orthodontics/Pediatric dentistry / Morphological basic dentistry / Periodontology / Surgical dentistry / Orthodontic/Pediatric dentistry
Keywords	Principal Investigator 骨代謝 / 破骨細胞 / メカニカルストレス / イメージング / 骨リモデリング / ＥＳ細胞 / 骨芽細胞 / ES細胞 / LDL受容体 / コレステロール / ＬＤＬ / lipid raft … More Except Principal Investigator … More LOX-1 / 破骨細胞 / 炎症性骨破壊 / 歯科矯正学 / 三次元モデル / 歯科矯正 / 細胞融合 / 炎症性骨吸収 / 口顎口蓋裂 / 三次元平均顔面形態 / 3Dプリント / 先天性疾患 / 平均立体像 / 相同モデル化 / 顔面形態 / 唇顎口蓋裂 / ヘッジホッグシグナル / ヘッジホッグ-Gli1 / 脂質 / 炎症整骨破壊 / ABCG1 / phosphatidylethanolamine / 細胞膜外葉 / LDL受容体 / 実験的歯周炎モデル / 歯周病 / 顔面形態変形 / 顎顔面形態変形 / 三次元サーフェスモデル / 相同モデル / ジェネリックデータ / 三次元病態平均画像 / 平均顎顔面 / 平均病態 / 頭蓋顎顔面 / FGF-2徐放化 / 添加的骨形成 / 幹細胞動員 / 骨髄微小環境形成 / SCF含有FGF2徐放化製剤 / SCF徐放化 / FGF徐放化製剤 / 造血-間葉相互作用 / 骨再生 / 造血幹細胞 / 間葉系幹細胞 / SCF含有FGF2/PLGA徐放製剤 / 再生骨 / 造血‐間葉相互作用 / sFRP1 / Wnt / ｂ－catenin / b-catenin / ｓFRP1 / RANKL産生 / 破骨細胞形成 / 骨芽細胞 / ３次元解析 / 頭部X線規格写真 / CT / 側面頭部X線規格写真 / 平均側面頭部X線規格写真トレース像 / 先天異常 / orthodontic diagnosis / CT-cephalogram / craniofacial anomaly / 矯正歯科診断 / ＣＴセファロ / 頭蓋顔面先天異常 Less

イメージング技術を用いた骨伸展時の骨細胞動態と骨リモデリング制御の解析Principal Investigator
- Principal Investigator
  
  岡安麻里
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57070:Developmental dentistry-related
- Research Institution
  The University of Tokyo
Identification of osteoclast-supporting cells and the investigation of the in vivo functions of the cells using mouse ES cellsPrincipal Investigator
- Principal Investigator
  
  Okayasu Mari
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  The University of Tokyo
Elucidation of the involvement of hedgehog-Gli1 axis in the bone remodeling by tooth movement.
- Principal Investigator
  
  Ohkubo Kazumi
- Project Period (FY)
  2017 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthodontics/Pediatric dentistry
- Research Institution
  The University of Tokyo
Development of Three-Dimensional Predictive Method for Treatment Outcomes in Craniofacial Congenital Abnormalities
- Principal Investigator
  
  Susami Takafumi
- Project Period (FY)
  2017 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthodontics/Pediatric dentistry
- Research Institution
  The University of Tokyo
Elucidation of Involvement of LOX-1 in inflammatory bone destruction and the molecular mechanism for the LOX-1 actions, and an approach to develop the new drug for bone diseases.
- Principal Investigator
  
  HAKEDA Yoshiyuki
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University
Development of Bone Regeneration Method Utilizing Hematopoietic-Mesenchymal Interaction and Clinical Application to Orthodontics
- Principal Investigator
  
  OHKUBO Kazumi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthodontics/Pediatric dentistry
- Research Institution
  The University of Tokyo
The development of a method of grasping average three dimentional pathology in patients with craniofacial anomaries
- Principal Investigator
  
  Susami Takafumi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthodontics/Pediatric dentistry
- Research Institution
  The University of Tokyo
Trial study for the establishment of the new therapeutical method for periodontal disease that targets oxidation LDL receptor LOX-1.
- Principal Investigator
  
  HAKEDA Yoshiyuki
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Periodontology
- Research Institution
  Meikai University
The elucidation of the role of lipid in bone resorption of inflammatory bone diseases; in particular, the exploration of the role of LOX-1 as an oxidized LDL receptor
- Principal Investigator
  
  HAKEDA Yoshiyuki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University
Functional analysis of sFRP1 and b-catenin for development of therapeutic agents on skeletal dysplasia
- Principal Investigator
  
  KAWASE-KOGA Yoko
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Surgical dentistry
- Research Institution
  Tokyo Medical University
  The University of Tokyo
Mechanism and its regulation of lipid rafts in the osteoclastic resorption of bonePrincipal Investigator
- Principal Investigator
  
  OKAYASU Mari
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthodontic/Pediatric dentistry
- Research Institution
  The University of Tokyo
Development of a new orthodontic diagnostic method based on the CT data for patients with congenital craniofacial anomalies
- Principal Investigator
  
  SUSAMI takafumi
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthodontic/Pediatric dentistry
- Research Institution
  The University of Tokyo

All 2020 2016 2015 2013 2012 Other

All Journal Article Presentation

[Journal Article] LDL uptake-dependent phosphatidylethanolamine translocation to the cell surface promotes fusion of osteoclast-like cells.2020
- Author(s)
  Kitano J F V, Ohyama Y, Hayashida C, Ito J, Okayasu M, Sato T, Ogasawara T, Tsujita M, Kakino A, Shimada J, Sawamura T, and Hakeda Y.
- Journal Title
  
  Journal of Cell Science
  
  Volume: ー
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05505
[Journal Article] 尖端巨大症による下顎前突症に顎矯正手術を行った２例2016
- Author(s)
  上床喜和子，須佐美隆史，井口隆人，大久保和美，岡安　麻里，内野　夏子，高橋　直子，松林　幸枝，阿部　雅修，末永　英之，森　良之，髙戸　毅
- Journal Title
  
  日本顎変形症学会雑誌
  
  Volume: 26(1) Pages: 26-36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26463085
[Journal Article] 先端巨大症による下顎前突症に顎矯正手術を行った2例2016
- Author(s)
  ２．上床喜和子、須佐美隆史、井口隆人、大久保和美、岡安麻里、内野夏子、髙橋直子、松林幸枝、阿部雅修、末永英之、森良之、髙戸毅
- Journal Title
  
  日本顎変形症学会雑誌
  
  Volume: 26 Pages: 26-36
- NAID
  130005152162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26463086
[Journal Article] Lectin-like oxidized low-density lipoprotein receptor-1 abrogation causes resistance to inflammatory bone destruction in mice, despite promoting osteoclastogenesis in the steady state.2015
- Author(s)
  Nakayachi M, Ito J, Hayashida C, Ohyama Y, Kakino A, Okayasu M, Sato T, Ogasawara T, Kaneda T, Suda N, Sawamura T, Hakeda Y
- Journal Title
  
  Bone. 75:170-182
  
  Volume: 75 Pages: 170-182
- DOI
  10.1016/j.bone.2015.02.025
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24659916, KAKENHI-PROJECT-25293422, KAKENHI-PROJECT-26870540, KAKENHI-PROJECT-26463085, KAKENHI-PROJECT-15K15759, KAKENHI-PROJECT-26670895, KAKENHI-PROJECT-25293376
[Journal Article] Maxillary Protraction in Patients With Cleft Lip and Palate in Mixed Dentition: Cephalometric Evaluation After Completion of Growth.2013
- Author(s)
  Susami T, Okayasu M, Inokuchi T, Ohkubo K, Uchino N, Uwatoko K, Takahashi-Ichikawa N, Nagahama K, Takato T.
- Journal Title
  
  Cleft Palate Craniofac J.
  
  Volume: - Issue: 5 Pages: 514-24
- DOI
  10.1597/12-032
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23593016, KAKENHI-PROJECT-26463085, KAKENHI-PROJECT-26463086
[Journal Article] Evaluation of mandibular hypoplasia in patients with hemifacial microsomia: a comparison between panoramic radiography and three-dimensional computed tomography.2012
- Author(s)
  Takahashi-Ichikawa N, Susami T, Nagahama K, Ohkubo K, Okayasu M, Uchino N, Uwatoko K, Saijo H, Mori Y, Takato T.
- Journal Title
  
  Cleft Palate Craniofac J.
  
  Volume: [Epub ahead of print]
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23593017
[Journal Article] Low-density lipoprotein receptor deficiency causes impaired osteoclastogenesis and increased bone mass in mice due to a defect in osteoclasticcell-cell fusion2012
- Author(s)
  Okayasu M, Nakayachi M, Hayashida C, Ito J, Kaneda T, Masuhara M, Suda N, Sato T, Hakeda Y
- Journal Title
  
  J Biol Chem
  
  Volume: (In press) Issue: 23 Pages: 19229-19241
- DOI
  10.1074/jbc.m111.323600
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592341, KAKENHI-PROJECT-22791792, KAKENHI-PROJECT-23593018, KAKENHI-PROJECT-24593079
[Presentation] 口蓋裂を伴うTreacher Collins 症候群ー上下顎移動術に先立ちSARMEを施行した2例2016
- Author(s)
  内野　夏子，須佐美隆史，大久保和美，井口　隆人，岡安　麻里，上床喜和子，高橋　直子，松林　幸枝，高橋　路子，平野友紀子，杉山　円，菅野勇樹，西條　英人，星　和人，髙戸　毅
- Organizer
  第40回日本口蓋裂学会総会・学術集会
- Place of Presentation
  ナレッジキャピタルコングレコンベンションセンター，大阪
- Year and Date
  2016-05-26
- Data Source
  KAKENHI-PROJECT-26463085
[Presentation] 口腔前庭形成術後の保護床としてのリップバンパー2016
- Author(s)
  西條　英人，井口　隆人，末永　英之，谷口明紗子，杉山　円，菅野　勇樹，岡安　麻里，内野　夏子，大久保和美，星　和人，須佐美隆史，髙戸　毅
- Organizer
  第40回日本口蓋裂学会総会・学術集会
- Place of Presentation
  ナレッジキャピタルコングレコンベンションセンター，大阪
- Year and Date
  2016-05-26
- Data Source
  KAKENHI-PROJECT-26463085
[Presentation] 両側性唇顎口蓋裂患者に対する咬合治療　両側性唇顎口蓋裂患者の不正咬合の特徴と顔面形成を考えた対処法2016
- Author(s)
  岡安　麻里，須佐美隆史，西條　英人，井口　隆人，大久保和美，髙戸　毅
- Organizer
  第40回日本口蓋裂学会総会・学術集会
- Place of Presentation
  ナレッジキャピタルコングレコンベンションセンター，大阪
- Year and Date
  2016-05-26
- Data Source
  KAKENHI-PROJECT-26463085
[Presentation] 両側性唇顎口蓋裂患者の不正咬合の特徴と顔面成長を考えた対処法2016
- Author(s)
  岡安麻里、須佐美隆史、西條英人、井口隆人、大久保和美、高戸毅
- Organizer
  第40回日本口蓋裂学会総会・学術集会
- Place of Presentation
  大阪
- Year and Date
  2016-05-26
- Data Source
  KAKENHI-PROJECT-26463086
[Presentation] 頭蓋顎顔面先天異常患者における平均顎顔面形態３Dモデル作成法の開発2016
- Author(s)
  内野　夏子，須佐美隆史，井口　隆人，岡安　麻里，大久保和美，上床喜和子，高橋　直子，松林　幸枝，髙戸　毅
- Organizer
  第75回日本矯正歯科学会大会
- Place of Presentation
  アスティとくしま，徳島
- Year and Date
  2016-11-07
- Data Source
  KAKENHI-PROJECT-26463085
[Presentation] レクチン様酸化LDL受容体-1(LOX-1)の破骨細胞形成と炎症性骨破壊に対する役割の解明2013
- Author(s)
  伊東順太、中谷地舞、林田千代美、岡安麻里、大山洋子、佐藤卓也、羽毛田慈之
- Organizer
  第55回歯科基礎医学会学術大会・総会
- Place of Presentation
  岡山コンベンションセンター、岡山、岡山県
- Data Source
  KAKENHI-PROJECT-25293376
[Presentation] Role of lectin-like oxidized low-density of lipoprotein receptor-1 in regulating osteoclastogenesis and inflammatory bone destruction.2013
- Author(s)
  Nakayachi M, Ito J, Okayasu M, Hayashida C, Sato T, Suda N, Sawamura T, Hakeda
- Organizer
  2nd Joint Meeting of the International Bone and Mineral Society and the Japanese Society for Bone and Mineral Research
- Place of Presentation
  Kobe Convention Center and Kobe Portpia Hotel, Kobe, Japan
- Data Source
  KAKENHI-PROJECT-25293376
[Presentation] Low density lipoprotein receptorの破骨細胞形成に果たす役割の解明2013
- Author(s)
  岡安麻里
- Organizer
  第16回骨代謝研究会
- Place of Presentation
  慶應義塾大学,　東京
- Invited
- Data Source
  KAKENHI-PROJECT-24593079
[Presentation] Lectin-like oxidized low-density of lipoprotein receptor-1 is involved in RANKL-production elevated by lipopolysaccharide-injection on mouse calvaria and thereby contributes to inflammatory bone destruction2013
- Author(s)
  Nakayachi M, Ito J, Okayasu M, Hayashida C, Sato T, Suda N, Sawamura T, Hakeda Y.
- Organizer
  35th Annual Meeting of the American Society for Bone and Mineral Research
- Place of Presentation
  Baltimore Convention Center, Baltimore, Maryland, USA
- Data Source
  KAKENHI-PROJECT-25293376
[Presentation] レクチン様酸化LDL受容体-１（LOX-1）の破骨細胞形成および炎症性骨吸収に果たす役割の解明2013
- Author(s)
  中谷地舞、伊東順太、岡安麻里、須田直人、羽毛田慈之
- Organizer
  第72回日本矯正歯科学会大会
- Place of Presentation
  キッセイ文化ホール・松本市総合体育館、松本、長野県
- Data Source
  KAKENHI-PROJECT-25293376
[Presentation] 口唇口蓋裂患者に対する二段階上下顎移動術の効果と安定性－上顎骨延長法と下顎後方移動術の組み合わせ
- Author(s)
  須佐美隆史、森良之、大久保和美、杉山円、井口隆人、岡安麻里、内野夏子、上床喜和子、高橋直子、高橋路子、平野友紀子、菅野勇樹、末永英之、古賀陽子、西條英人、高戸毅
- Organizer
  日本口蓋裂学会総会・学術集会
- Place of Presentation
  札幌
- Year and Date
  2014-05-29 – 2014-05-30
- Data Source
  KAKENHI-PROJECT-26463086
[Presentation] レクチン様酸化LDL受容体-1 (LOX-1)欠損マウスは骨量を減少させるが炎症性骨吸収に抵抗を示す
- Author(s)
  中谷地舞、伊東順太、岡安麻里、須田直人、羽毛田慈之
- Organizer
  第73回日本矯正歯科学会大会・第5回日韓ジョイントミーティング
- Place of Presentation
  幕張
- Year and Date
  2014-10-20 – 2014-10-22
- Data Source
  KAKENHI-PROJECT-26670895
[Presentation] レクチン様酸化LDL受容体-1 (LOX-1)欠損マウスは骨量を減少させるが炎症性骨吸収に抵抗を示す
- Author(s)
  中谷地舞, 伊東順太, 岡安麻里, 須田直人, 羽毛田慈之
- Organizer
  第74回日本矯正歯科学会大会・第5回日韓ジョイントミーティンク
- Place of Presentation
  幕張
- Year and Date
  2014-10-20 – 2014-10-22
- Data Source
  KAKENHI-PROJECT-25293376
[Presentation] 頭蓋顔面先天異常におけるCTデータを基にしたセファログラムの有用性
- Author(s)
  長濱浩平、須佐美隆史、大久保和美、高橋直子、岡安麻里、内野夏子、上床喜和子、高戸毅
- Organizer
  第７０回日本矯正歯科学会大会＆第４回国際会議
- Place of Presentation
  名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-23593017
[Presentation] 下顎枝垂直骨切り術（IVRO)における近位骨片に関する偶発症の検討
- Author(s)
  古賀陽子、森良之、藤居泰行、菅野勇樹、末永英之、安部貴大、　西條英人、井口隆人、岡安麻里、大久保和美、須佐美隆史、高戸毅
- Organizer
  第24回日本顎変形症学会総会・学術大会
- Place of Presentation
  アクロス福岡、福岡
- Year and Date
  2014-06-10 – 2014-06-11
- Data Source
  KAKENHI-PROJECT-25670852

1. OHKUBO Kazumi (10396715)

# of Collaborated Projects: 5 results

# of Collaborated Products: 8 results
2. HAKETA Yoshiyuki (90164772)

# of Collaborated Projects: 4 results

# of Collaborated Products: 8 results
3. SUSAMI takafumi (80179184)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
4. UCHINO Natsuko (30569637)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
5. NAGAHAMA Kohei (80587775)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
6. OGASAWARA Toru (20359623)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. SAWAMURA Tatsuya (30243033)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
8. ITO Junta (40609096)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
9. 西條英人 (80372390)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
10. 大庭伸介 (20466733)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. SUGIYAMA Madoka (90451814)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. NAGAHAMA Kohei (60401361)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
13. TAKAHASHI Naoko (10569635)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
14. YANO Fumiko (80529040)

# of Collaborated Projects: 1 results

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15. SATO Takuya (00316689)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
16. HAYASHIDA Chiyomi (40710900)

# of Collaborated Projects: 1 results

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17. KANEDA Toshio (70339521)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. KAWASE-KOGA Yoko (10392408)

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19. KURABAYASHI Kumiko (40586757)

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20. KANNO Yuki (80451813)

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21. INAKI Ryoko (90632456)

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22. SHIN Kitetsu (40187555)

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23. 星和人 (30344451)

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24. 末永英之 (10396731)

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25. 森芳史 (60757954)

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26. 北條宏徳 (80788422)

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27. 菅家康介 (90779810)

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28. 疋田温彦 (60443397)

# of Collaborated Projects: 1 results

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29. 増原正明

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# of Collaborated Products: 1 results
30. 須田直人

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# of Collaborated Products: 1 results
31. 河瀬陽子

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# of Collaborated Products: 1 results

OKAYASU MARI 岡安 麻里

OKAYASU Mari 岡安 麻里

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イメージング技術を用いた骨伸展時の骨細胞動態と骨リモデリング制御の解析Principal Investigator

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Identification of osteoclast-supporting cells and the investigation of the in vivo functions of the cells using mouse ES cellsPrincipal Investigator

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Mechanism and its regulation of lipid rafts in the osteoclastic resorption of bonePrincipal Investigator

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[Journal Article] LDL uptake-dependent phosphatidylethanolamine translocation to the cell surface promotes fusion of osteoclast-like cells.2020

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[Journal Article] 尖端巨大症による下顎前突症に顎矯正手術を行った２例2016

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[Journal Article] 先端巨大症による下顎前突症に顎矯正手術を行った2例2016

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OKAYASU MARI 岡安麻里

OKAYASU Mari 岡安麻里

[Presentation] 両側性唇顎口蓋裂患者に対する咬合治療　両側性唇顎口蓋裂患者の不正咬合の特徴と顔面形成を考えた対処法2016