KUDO Yoshihisa 工藤佳久

… Alternative Names

工藤佳久クドウヨシヒサ

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Researcher Number	20080179
Other IDs
External Links
Affiliation (Current)	2025: 東京医科大学, 医学部, 兼任教授
Affiliation (based on the past Project Information) *help	2008: Tokyo University of Pharmacy and Life Science, 名誉教授 2006 – 2007: 東京薬科大学, その他, 名誉教授 2006: 東京薬科大学, その他・名誉教授 2005: 東京薬科大学, 生命科学部, 名誉教授 1995 – 2004: 東京薬科大学, 生命科学部, 教授 1986: Mitsubishi-Kasei Institute of Life Sciences, 室長
Review Section/Research Field	Principal Investigator Biological Sciences / Neuroscience in general Except Principal Investigator 応用薬理学・医療系薬学 / Anesthesiology/Resuscitation studies / 神経・脳内生理学 / Biological Sciences / Cell biology / Neurochemistry/Neuropharmacology
Keywords	Principal Investigator アストロサイト / ニューロン / グリア細胞 / カルシウム / Ca^<2+> / neuron / feedback mechanism / lipopolysaccharide / glutamate / cytokines … More / calcium oscillation / astrocytes / 遺伝子クローニング / Ca^<2+>オシレーション / アンチオキシダント / メタロペプチダーゼ / ディファレンシアルディスプレー法 / t-ACPD / グルタミン酸トランスポーター / シナプス / エンドセリン / 神経栄養因子 / トランスポーター電位 / アストログリア / シュワン細胞 / Cre-loxP / NO / 成長因子 / フィードバック調節 / リポポリサッカライド / グルタミン酸 / サイトカイン / カルシウムオシレーション / COOLED CCD / CALCIUM / CYCLIC AMP DEPENDENT PROTEIN KINASE / CALCIUM CALMODULINE DEPENDENT PROTEIN KINASE / IMAGING / FLUOROPROBE / 海馬ニューロン / 細胞内情報伝達 / cAMP / プロテインキナーゼ / 情報伝達 / イメージング / 蛍光色素 / 偏光変調 / 可視化 / 神経細胞 / ペプチド試薬 / 冷却CCD / 蛍光試薬 / CAMP / CAMP依存性キナーゼ / カルシウムイオン / カルモデュリン依存性キナーゼ / 国際共同研究 / 総括班会議 / 形態 / 精神疾患 / 高次機能 / 中間評価 / ホームページ / 成果報告会 / 国際会議 / 精神神経疾患 / ワークショップ / オリゴデンドロサイト / ミクログリア / グリア画像データベース化 / 国際シンポジウム / 日米ジョイント会議 / 国際交流 / サマーワークショップ / 公開シンポジウム / 情報処理機構 / 回路網 / 蛍光 / カルモジュリン / リン酸化 / 可視化試薬 / カルモジュリン依存性キナーゼ … More Except Principal Investigator Calcineurin / Cyclophilin D / Synaptic plasticity / Spastic paralysis / Mephenesin / Chlorpromazine / Decerebrate rigidity / バクロフェン / 固縮 / 痙縮 / 痙性麻痺 / メフェネシン / クロルプロマジン / 除脳固縮 / Ca^<2+>exchanger / Na^+ / Hypoxia Inducible Factor(HIF) / FK506 / Cyclosporin A / Mitochondrial Permeability Transition(MPT) / Hypoxia / Rat / 低酸素反応性因子(HIF) / 神経細胞死 / イムノフィリン / カルシニューリン / NCX / DNA chip / 免疫抑制剤 / Ca2_+濃度 / MPT / Ca2+ exchanger (NCX) / Na+ / DNA Chip / カルシニューン / HIF(低酸素反応性因子) / CsJ / 低酸素 / Protein phosphatase / Protein kinase / Dephosphorylation / Phosphorylation / Long-term depression / Long-term potentiation / Visual cortex / 蛋白質ホスファターゼ / 蛋白質キナーゼ / 蛋白質脱リン酸化 / 蛋白質リン酸化 / 長期抑圧 / 長期増強 / シナプス可塑性 / 視覚野 / ホールセル記録法 / GFAP / Gene Chip / サイトカイン / 成長因子 / Ca応答 / IP3イメージング / DNAマイクロアレイ / オクトパミン受容体 / 伝達物質放出 / ヘミチャネル / トランスジェニック動物 / 人工受容体 / 電気生理学 / 代謝型グルタミン酸受容体 / トランジェニック動物 / Ca振動 / シナプス応答 / アストロサイト / 同期的自発Ca変動 / Kイオン選択性電極 / Caイメージング / シナプス外NMDA受容体 / 高頻度反復シナプス刺激 / プラトー状電位 / CAAXモチーフ特異的プロテアーゼ / FRET(蛍光共鳴エネルギー転移) / 細胞内プロテアーゼ / 二重蛍光標識基質 / カスパーゼ / コラゲナーゼ / 細胞内注入 / アクリロダン標識基質 / 蛍光基質 / グルタミン酸刺激 / 細胞死 / カスパーゼ1 / 海馬スライス培養 / FRET / 二重蛍光基質 / 可視化解析 / 細胞内プロテオリシス / 神経発達 / グリア研究会 / 神経疾患治癒 / グリア細胞 / 赤外線顕微鏡 / ノルアドレナリン / Synaphin / 視交叉上核 / 小脳中位核 / 瞬目反射法 / 連合学習 / リン酸化部分ペプチド抗体 / タンパク質キナーゼ / イメージング法 / 微分表示法 / 記憶・学習 / リン酸化 / SNARE複合体 / シナプス小胞 / Map Kinase / Free energy barrier / Synapsin I / Synerphin / Fear conditioning / PKA / CaMK / membrane fusion / Associative learning / SNARE / Synaptic vesicle / Fear Conditioning Less

グリアーニューロン回路網による情報処理機構研究組織の構築Principal Investigator
- Principal Investigator
  
  工藤佳久
- Project Period (FY)
  2003 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo University of Pharmacy and Life Science
アストロサイトの伝達物質応答による神経回路活動の制御
- Principal Investigator
  
  宮川博義
- Project Period (FY)
  2003 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo University of Pharmacy and Life Science
New approach to investigate the mechanisms of Ischemic neuronal death and establishment of new way of brain resuscutation
- Principal Investigator
  
  ISHII Nagao
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Tokyo Medical University, Department of Anesthesiology
生細胞における蛋白質分解過程の可視化解析
- Principal Investigator
  
  高橋健治
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cell biology
- Research Institution
  Tokyo University of Pharmacy and Life Science
Modulation of synaptic functions by astrocytesPrincipal Investigator
- Principal Investigator
  
  KUDO Yoshihisa
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (B)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo University of Pharmacy and Life Science
Ca^<2+>/カルモジュリン依存性キナーゼ活性の可視化試薬の開発と応用Principal Investigator
- Principal Investigator
  
  工藤佳久
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo University of Pharmacy and Life Science
DEVELOPMENT OF SYSTEMS FOR IMAGING INTRACELLULAR SIGNAL TRANSDUCTIONS BY FLUOROPROBESPrincipal Investigator
- Principal Investigator
  
  KUDO Yoshihisa
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neuroscience in general
- Research Institution
  TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCE
神経活動によるシナプスの強化・固定のメカニズム
- Principal Investigator
  
  吉岡亨
- Project Period (FY)
  1995 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Waseda University
グリア研究の最前線
- Principal Investigator
  
  池中一裕
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Okazaki National Research Institutes
An approach toward real-time imaging of protein phosphorylation in visual cortical neurons
- Principal Investigator
  
  TSUMOTO Tadaharu
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  神経・脳内生理学
- Research Institution
  Osaka University
Application of models of spasticity and spastic paralysis
- Principal Investigator
  
  FUKUDA Hideomi
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  The University of Tokyo

All 2009 2008 2007 2006 2005 2004

All Journal Article Presentation Book

[Book] 生命科学がわかる2008
- Author(s)
  工藤佳久, 都筑幹夫
- Total Pages
  205
- Publisher
  技術評論社
- Data Source
  KAKENHI-PROJECT-15082101
[Book] 「グリア研究の新しい展開」2007
- Author(s)
  工藤佳久
- Total Pages
  13
- Publisher
  Brain and Nerve
- Data Source
  KAKENHI-PROJECT-15082101
[Book] 脳の高次機能をささえるアストロサイト-脳の中の新しい風景-2006
- Author(s)
  工藤佳久
- Total Pages
  8
- Publisher
  オーム社
- Data Source
  KAKENHI-PROJECT-15082101
[Journal Article] Multiple inhibitory pathways for lipopolysaccharide- and pro-inflammatory cytokine-induced nitric oxide production in cultured astrocytes.2007
- Author(s)
  Kozuka N, Kudo Y, Morita M
- Journal Title
  
  Neuroscience 144(3)
  
  Pages: 911-919
- Data Source
  KAKENHI-PROJECT-15082101
[Journal Article] Multiple inhibitory pathways for lipopolysaccharide- and pro-inflammatory cytokine--induced nitric oxide production in cultured astrocytes.2007
- Author(s)
  N.Kozuka, Y.Kudo, M.Morita
- Journal Title
  
  Neuroscience 144
  
  Pages: 911-919
- Data Source
  KAKENHI-PROJECT-15082207
[Journal Article] PACAP/PAC1 autocrine system promotes proliferation and astrogenesis in neural progenitor cells.2007
- Author(s)
  Nishimoto M, Furuta A, Aoki S, Kudo Y, Miyakawa H, Wada K
- Journal Title
  
  Glia. 55(3)
  
  Pages: 317-327
- Data Source
  KAKENHI-PROJECT-15082101
[Journal Article] Use of the exogenous Drosophila octomamine receptor gene to study Gq-coupled receptor-mediated responses in mamalian neurons2006
- Author(s)
  Morita, M., Susuki, J., Amino, H., Yoshiki, F., Moizumi, S., Kudo, Y.
- Journal Title
  
  Neuroscience 137
  
  Pages: 545-553
- Data Source
  KAKENHI-PROJECT-15082101
[Journal Article] Use of the exogenous drosophila octopamine receptor gene to study Gq-Coupled receptor-meciatec responses in mammalian neurons2006
- Author(s)
  M.Morita, J.Susuki, H.Amino, F.Yoshiki, S.Moizumi, Y.Kudo
- Journal Title
  
  Neuroscience 137
  
  Pages: 545-553
- Data Source
  KAKENHI-PROJECT-15082207
[Journal Article] A novel effect of bifemelane, a nootropic drug, on intracellular Ca2+ levels in rat cerebral astrocytes.2006
- Author(s)
  Yoshida Y, Nakane A, Morita M, Kudo Y
- Journal Title
  
  J Pharmacol Sci. 100(2)
  
  Pages: 126-132
- NAID
  10018240701
- Data Source
  KAKENHI-PROJECT-15082101
[Journal Article] Use of the exogenous Drosophila octopamine receptor gene to study Gq-coupled receptor-mediated responses in mammalian neurons.2006
- Author(s)
  Morita M, Susuki J, Amino H, Yoshiki F, Moizumi S, Kudo Y
- Journal Title
  
  Neuroscience. 137(2)
  
  Pages: 545-553
- Data Source
  KAKENHI-PROJECT-15082101
[Journal Article] A novel effect of befemelane, a nootropic drug, on intracellular Ca2+ level in rat cerebral astrocytes.2006
- Author(s)
  Yoshida, Y., Nakane, A., Morita, M., Kudo, Y.
- Journal Title
  
  J.Pharmacol.Sci. 100
  
  Pages: 126-132
- Data Source
  KAKENHI-PROJECT-15082101
[Journal Article] Effects of bifemelane on the calcium level and ATP release of the human origin astrocyte clonal cell.2006
- Author(s)
  Yoshida Y, Kumagai H, Ohkubo Y, Tsuchiya R, Morita M, Miyakawa H, Kudo Y
- Journal Title
  
  J Pharmacol Sci. 102(1)
  
  Pages: 121-128
- NAID
  10020346475
- Data Source
  KAKENHI-PROJECT-15082101
[Journal Article] Direct evidence for mutual interactions between perineuronal astrocytes and interneurons in the CA1 region of the rat hippocampus2005
- Author(s)
  Y.Yamazaki, Y.Hosumi, K.Kaneko, J.LI, S.Fujii, H.Miyakawa, Y.Kudo, H.Kato
- Journal Title
  
  Neuroscience 134
  
  Pages: 791-802
- Data Source
  KAKENHI-PROJECT-15082207
[Journal Article] Autocrine activation of EGF receptor promotes oscillation of glutamate-induced calcium incerase in astrocytes cultured in rat cerebral cortex.2005
- Author(s)
  Morita, M., Kozuka, N., Itofusa, R., Yukawa, M., Kudo, Y.
- Journal Title
  
  J.Neurochem. 95
  
  Pages: 871-879
- Data Source
  KAKENHI-PROJECT-15082101
[Journal Article] Ca2+-ependent induction of intracellular Ca2+ oscillation in hippocampal astrocytes during metabotropic glutamate receptor activation.2005
- Author(s)
  Yoshida, Y., Tsuchiya, R., Matsumoto, N., Morita, M., Miyakawa, H., Kudo, Y.
- Journal Title
  
  J.Pharmacol.Sci. 97
  
  Pages: 212-218
- Data Source
  KAKENHI-PROJECT-15082101
[Journal Article] グリア細胞-その新しい展望、「グリア細胞におけるカルシウムダイナミックス」2005
- Author(s)
  森田光洋, 工藤佳久
- Journal Title
  
  Clinical Neuroscience 23(2)
  
  Pages: 148-152
- Data Source
  KAKENHI-PROJECT-15082207
[Journal Article] Lipopolysaccharide and proinflammatory cytokines require distinct astrocyte state to induce nitric oxide production.2005
- Author(s)
  Kozuka, N., Itofusa, R., Kudo, Y., Morita, M.
- Journal Title
  
  J.Neurosci.Res. 82
  
  Pages: 717-728
- Data Source
  KAKENHI-PROJECT-15082101
[Journal Article] 脳機能発現におけるグリア細胞の役割2005
- Author(s)
  工藤佳久
- Journal Title
  
  神経研究の進歩 49
  
  Pages: 843-849
- Data Source
  KAKENHI-PROJECT-15082101
[Journal Article] カルシウムイメージング機器の現状、「バイオ高性能機器・新技術利用マニュアル(小原, 谷口, 市川, 猪飼編)」2004
- Author(s)
  工藤佳久, 森田光洋
- Journal Title
  
  蛋白質核酸酵素 49巻11号
  
  Pages: 1623-1640
- Data Source
  KAKENHI-PROJECT-15082207
[Journal Article] Adenosine A1-receptor mediated tonic inhibition of glutamate release at rat hippocampla CA3-CA1 synapses in primarily due to inhibition of Ntyope Ca2+ channels.2004
- Author(s)
  Manita, S., Kawamura, Y., Sato, K., Inoue, M., Kudo, Y., Miyakawa, H.
- Journal Title
  
  Europ.J.Pharmacol. 499
  
  Pages: 265-274
- Data Source
  KAKENHI-PROJECT-15082101
[Journal Article] Glutamate release during hippocampal CA3-CA1 synapse LTP monitored optically by detecting glial glutamate transporter activity2004
- Author(s)
  Kawamura, Y., Manita, S., Nakamura, T., INoue, M., Kudo, Y., Miyakawa, H.
- Journal Title
  
  Europ.J.Neuroscience 19
  
  Pages: 1591-1600
- Data Source
  KAKENHI-PROJECT-15082101
[Journal Article] Novel method for quantification of brain cell swelling in rat hippocampal slices.2004
- Author(s)
  Nakajima, R., Nakamura, T., Ogawa, M., Miyakawa, H., Kudo, Y.
- Journal Title
  
  J.Neuroscience Res. 76
  
  Pages: 723-733
- Data Source
  KAKENHI-PROJECT-15082101
[Presentation] 特別講演脳機能とその病態におけるグリア細胞の役割2009
- Author(s)
  工藤佳久
- Organizer
  第18回神経行動薬理・若手研究者の集い
- Place of Presentation
  横浜
- Year and Date
  2009-03-19
- Data Source
  KAKENHI-PROJECT-15082101
[Presentation] cAMP依存性プロテインキナーゼ活性のための新しい蛍光指示薬2008
- Author(s)
  工藤佳久、柴内佑介、伊藤久央
- Organizer
  Neuroscience 2008(第31回日本神経科学大会)
- Place of Presentation
  東京
- Year and Date
  2008-07-11
- Data Source
  KAKENHI-PROJECT-15082101
[Presentation] Roles of astrocyte-neuron interation on synaptic plasticity2007
- Author(s)
  Kudo, Y.
- Organizer
  大連(中国)アジア太平洋神経化学会
- Place of Presentation
  大連医科大学(中華人民共和国)
- Data Source
  KAKENHI-PROJECT-15082101

1. MIYAKAWA Hiroyoshi (90166124)

# of Collaborated Projects: 4 results

# of Collaborated Products: 7 results
2. MORITA Mitsuhiro (50297602)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
3. NAKAMURA Takeshi (50227906)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 池中一裕 (00144527)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. TSUMOTO Tadaharu (50028619)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. HATA Yoshio (40212146)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KIYAMA Hiroshi (00192021)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. ISHII Nagao (00074865)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. UCHINO Hiroyuki (60266476)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. FUKUDA Hideomi (50080172)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. OKA Jun-ichiro (40134613)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. ONO Hideki (00080200)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 吉岡亨 (70046027)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 五十嵐道弘 (50193173)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 谷口寿章 (10257636)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 阿部輝雄 (50010103)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 八尾寛 (00144353)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 桐野豊 (10012668)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 榊原学 (10135379)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 和中明生 (90210989)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 祖父江元 (20148315)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 加藤泰治 (60094364)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 高橋健治 (70011533)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 西井亘 (30287461)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 高坂新一 (50112686)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 小澤瀞司 (40049044)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 井上雅司 (30339098)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 谷藤高子 (10311648)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 畠義郎 (20089882)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 片山佳樹 (70284528)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 高木博 (80247220)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 高橋俊明 (30349451)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 近江明文 (70246221)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. SASAMOTO Kazumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. UCHIYAMA Shigeru

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. HIGASHI Hideyoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. SHIBASAKI Futoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. 高橋正身

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KUDO Yoshihisa 工藤 佳久

工藤 佳久 クドウ ヨシヒサ

Research Projects

Research Products

Co-Researchers

グリアーニューロン回路網による情報処理機構研究組織の構築Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

アストロサイトの伝達物質応答による神経回路活動の制御

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

New approach to investigate the mechanisms of Ischemic neuronal death and establishment of new way of brain resuscutation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

生細胞における蛋白質分解過程の可視化解析

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Modulation of synaptic functions by astrocytesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Ca^<2+>/カルモジュリン依存性キナーゼ活性の可視化試薬の開発と応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

DEVELOPMENT OF SYSTEMS FOR IMAGING INTRACELLULAR SIGNAL TRANSDUCTIONS BY FLUOROPROBESPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

神経活動によるシナプスの強化・固定のメカニズム

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グリア研究の最前線

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An approach toward real-time imaging of protein phosphorylation in visual cortical neurons

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Application of models of spasticity and spastic paralysis

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[Book] 生命科学がわかる2008

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[Book] 「グリア研究の新しい展開」2007

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[Book] 脳の高次機能をささえるアストロサイト-脳の中の新しい風景-2006

KUDO Yoshihisa 工藤佳久

工藤佳久クドウヨシヒサ